Read in Data

read_csv("../output/rev_coral_join.csv") -> rev_coral_join
## Rows: 778 Columns: 5897
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: ","
## chr    (6): Clade, Majority, sample_id, species, region, reef
## dbl (5891): ITS2_type, its2_count, ASV0001, ASV0002, ASV0003, ASV0004, ASV00...
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.

Clade C and Non-Clade C Label Subsetting

# Assuming 'df' is your data frame with a column 'labels' and you want to balance the labels

# Extract the minority class samples (139 observations)
minority_class <- rev_coral_join[rev_coral_join$Clade == 'C', ]

# Extract the majority class samples (the rest of the dataset)
majority_class <- rev_coral_join[rev_coral_join$Clade != 'C', ]

# Randomly sample from the majority class to match the size of the minority class
set.seed(42)  # Set a seed for reproducibility
balanced_majority <- majority_class[sample(nrow(majority_class), nrow(minority_class)), ]

# Combine the balanced datasets
balanced_df <- rbind(balanced_majority, minority_class)

# Shuffle the rows to randomize the order
balanced_df <- balanced_df[sample(nrow(balanced_df)), ]
dim(balanced_df)
## [1]  278 5897
unique(balanced_df$Clade)
## [1] "C" "A" "G" "D"
length(balanced_df$Clade=="C")
## [1] 278
length(balanced_df$Clade != "C")
## [1] 278

Read in results from PCA Clade C Dim 1 Results

read_csv("../output/clade_c_pca_Ranks.csv") -> clade_c_pca_Ranks
## Rows: 3226 Columns: 1
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: ","
## chr (1): ASV
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
# subset ASV columns for Logistic Regression based on clade C PCA results in Dimension 1
balanced_df %>% 
  select(sample_id, Clade, (clade_c_pca_Ranks$ASV)) -> lr_data
#glimpse(lr_data)
head(lr_data)
## # A tibble: 6 × 3,228
##   sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##   <chr>      <chr>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
## 1 SKAU-R2-23 C           0       0       0       0       0       0       0
## 2 SWAJ-R4-3  A           0       0       0       0       0       0       0
## 3 SYAN-R3-19 C           0       0       0       0       0       0       0
## 4 PMAQ-R2-19 A           0       0       0       0       0       0       0
## 5 SDOG-R3-6  A           0       0       0       0       0       0       0
## 6 PDOG-R2-22 A         234     147      90     103      60      42      49
## # ℹ 3,219 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …
lr_data %>% 
  mutate(Clade = case_when(Clade=="C" ~ 1, 
                           .default = 0)) -> lr_data

Double-check if any columns sum to 0

# take out sample and clade columns for numeric only
map(lr_data[,-c(1,2)], ~sum(.)) %>% 
  as.data.frame() %>% 
  pivot_longer(cols = everything()) %>% 
  filter(value==0)
## # A tibble: 0 × 2
## # ℹ 2 variables: name <chr>, value <dbl>
dim(lr_data)
## [1]  278 3228

  • No columns sum to 0. This had been taken care of when subsetting for Clade C to have ASVs sequenced in Clade C.

  • There is sequencing data for Clade C and non-Clade C observations that are all non-zero when summing each ASV column.

dim(lr_data)
## [1]  278 3228

Inserted this afterwards to be able to work on Random Forest modeling

write_csv(lr_data, "../output/lr_data.csv")

t-SNE plot of Clade C and non-Clade C

library(tsne)
library(plotly)
## 
## Attaching package: 'plotly'
## The following object is masked from 'package:ggplot2':
## 
##     last_plot
## The following object is masked from 'package:stats':
## 
##     filter
## The following object is masked from 'package:graphics':
## 
##     layout
data(lr_clr_df)
## Warning in data(lr_clr_df): data set 'lr_clr_df' not found
features <- subset(lr_clr_df, select = -c(1,2)) 

set.seed(0)
tsne <- tsne(features, initial_dims = 2)
## sigma summary: Min. : 0.0678215778208645 |1st Qu. : 0.0916334485210355 |Median : 0.106756334806171 |Mean : 0.145508390913786 |3rd Qu. : 0.136747935696713 |Max. : 1.33140136971437 |
## Epoch: Iteration #100 error is: 11.9931544984992
## Epoch: Iteration #200 error is: 0.176468277811214
## Epoch: Iteration #300 error is: 0.167732330784209
## Epoch: Iteration #400 error is: 0.165431266607314
## Epoch: Iteration #500 error is: 0.16515252252442
## Epoch: Iteration #600 error is: 0.165050262676511
## Epoch: Iteration #700 error is: 0.165008046466993
## Epoch: Iteration #800 error is: 0.164989381654186
## Epoch: Iteration #900 error is: 0.164981014702747
## Epoch: Iteration #1000 error is: 0.164977194945977
tsne <- data.frame(tsne)
pdb <- cbind(tsne,lr_clr_df$Clade)
options(warn = -1)
fig2 <-  plot_ly(data = pdb ,x =  ~X1, y = ~X2, type = 'scatter', mode = 'markers', split = ~lr_clr_df$Clade)

fig2 <- fig2 %>%
  layout(
    plot_bgcolor = "#e5ecf6"
  )

fig2

GGally::ggpairs for Clade C

# quick subset for visualization
subset_lr <- lr_clr_df[,-1] %>% 
  select(1:10)

GGally::ggpairs(subset_lr, aes(color = as.factor(Clade))) -> ggpairs_10_clade_c
## Registered S3 method overwritten by 'GGally':
##   method from   
##   +.gg   ggplot2
ggpairs_10_clade_c

ggsave("../plots/ggpairs_10_clade_c.png", width = 14, height = 12, plot = ggpairs_10_clade_c)

Separate Training and Testing for later after experimenting with whole dataset first

set.seed(1234)
Z <- sample(nrow(lr_clr_df), .85*nrow(lr_clr_df))
lr_train <- lr_clr_df[Z,]
lr_test <- lr_clr_df[-Z,]

# take a peek at training data
head(lr_train, 20)
## # A tibble: 20 × 3,228
##    sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##    <chr>      <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
##  1 PWAJ-R3-8      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  2 SYAN-R1-11     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  3 SMAQ-R1-5      1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  4 PWAJ-R3-1      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  5 SYAN-R1-16     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  6 PMAQ-R2-29     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  7 PMAQ-R1-4      1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  8 PKAU-R3-3      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
##  9 SYAN-R4-3      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 10 PKAU-R1-17     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 11 SWAJ-R3-23     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 12 PMAQ-R2-19     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 13 SYAN-R1-12     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 14 PDOG-R1-29     0 -0.0759   5.72   -0.135 -7.66     0.122  8.87     0.130
## 15 PMAQ-R2-18     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 16 SFAR-R2-25     0 -0.0759  -0.167   4.11  -0.0486   0.122 -0.0382  -1.83 
## 17 SKAU-R2-31     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 18 SWAJ-R3-10     0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 19 SYAN-R1-20     1 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## 20 PMAQ-R2-7      0 -0.0759  -0.167  -0.135 -0.0486   0.122 -0.0382   0.130
## # ℹ 3,219 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …
dim(lr_train)
## [1]  236 3228
dim(lr_test)
## [1]   42 3228

check label distribution of CLade C = 1 and Non-Clade-C = 0

ggplot(lr_clr_df, aes( x = Clade)) +
  geom_histogram(stat = 'count') +
  ggtitle("Label Distributions of Clade C = 1 vs. Non-Clade C = 0") +
  theme_bw()

Experiment with whole dataset based on CLR Transformation

glmnet::glmnet

3226

y = as.factor(lr_clr_df$Clade)
x = as.matrix(lr_clr_df[,-c(1,2)])

any(is.na(x))
## [1] FALSE
library(glmnet)
## Loading required package: Matrix
## 
## Attaching package: 'Matrix'
## The following objects are masked from 'package:tidyr':
## 
##     expand, pack, unpack
## Loaded glmnet 4.1-8
## 
## Attaching package: 'glmnet'
## The following object is masked from 'package:compositions':
## 
##     rmult
lr_model <- glmnet(x, y, 
                 family = "binomial", 
                 #alpha = 1 # lasso L1 norm
                 alpha = 0 # ridge L2 norm
                )
plot(lr_model)

summary(lr_model)
##            Length Class     Mode     
## a0            100 -none-    numeric  
## beta       322600 dgCMatrix S4       
## df            100 -none-    numeric  
## dim             2 -none-    numeric  
## lambda        100 -none-    numeric  
## dev.ratio     100 -none-    numeric  
## nulldev         1 -none-    numeric  
## npasses         1 -none-    numeric  
## jerr            1 -none-    numeric  
## offset          1 -none-    logical  
## classnames      2 -none-    character
## call            5 -none-    call     
## nobs            1 -none-    numeric
lr_model
## 
## Call:  glmnet(x = x, y = y, family = "binomial", alpha = 0) 
## 
##       Df  %Dev  Lambda
## 1   3226  0.00 161.800
## 2   3226  3.00 154.400
## 3   3226  3.13 147.400
## 4   3226  3.27 140.700
## 5   3226  3.42 134.300
## 6   3226  3.57 128.200
## 7   3226  3.73 122.400
## 8   3226  3.89 116.800
## 9   3226  4.06 111.500
## 10  3226  4.24 106.500
## 11  3226  4.42 101.600
## 12  3226  4.61  96.990
## 13  3226  4.81  92.590
## 14  3226  5.02  88.380
## 15  3226  5.24  84.360
## 16  3226  5.46  80.530
## 17  3226  5.69  76.870
## 18  3226  5.93  73.370
## 19  3226  6.18  70.040
## 20  3226  6.44  66.850
## 21  3226  6.71  63.820
## 22  3226  6.98  60.920
## 23  3226  7.27  58.150
## 24  3226  7.57  55.500
## 25  3226  7.88  52.980
## 26  3226  8.19  50.570
## 27  3226  8.52  48.270
## 28  3226  8.86  46.080
## 29  3226  9.21  43.990
## 30  3226  9.57  41.990
## 31  3226  9.95  40.080
## 32  3226 10.33  38.260
## 33  3226 10.73  36.520
## 34  3226 11.14  34.860
## 35  3226 11.56  33.270
## 36  3226 11.99  31.760
## 37  3226 12.43  30.320
## 38  3226 12.89  28.940
## 39  3226 13.36  27.620
## 40  3226 13.84  26.370
## 41  3226 14.33  25.170
## 42  3226 14.83  24.030
## 43  3226 15.35  22.930
## 44  3226 15.88  21.890
## 45  3226 16.42  20.900
## 46  3226 16.98  19.950
## 47  3226 17.54  19.040
## 48  3226 18.12  18.180
## 49  3226 18.71  17.350
## 50  3226 19.31  16.560
## 51  3226 19.92  15.810
## 52  3226 20.54  15.090
## 53  3226 21.18  14.400
## 54  3226 21.82  13.750
## 55  3226 22.47  13.120
## 56  3226 23.14  12.530
## 57  3226 23.81  11.960
## 58  3226 24.49  11.410
## 59  3226 25.19  10.900
## 60  3226 25.89  10.400
## 61  3226 26.59   9.928
## 62  3226 27.31   9.476
## 63  3226 28.03   9.046
## 64  3226 28.76   8.635
## 65  3226 29.50   8.242
## 66  3226 30.24   7.868
## 67  3226 30.98   7.510
## 68  3226 31.73   7.169
## 69  3226 32.49   6.843
## 70  3226 33.25   6.532
## 71  3226 34.01   6.235
## 72  3226 34.77   5.952
## 73  3226 35.54   5.681
## 74  3226 36.30   5.423
## 75  3226 37.07   5.176
## 76  3226 37.84   4.941
## 77  3226 38.61   4.716
## 78  3226 39.37   4.502
## 79  3226 40.14   4.297
## 80  3226 40.90   4.102
## 81  3226 41.67   3.916
## 82  3226 42.42   3.738
## 83  3226 43.18   3.568
## 84  3226 43.93   3.406
## 85  3226 44.68   3.251
## 86  3226 45.42   3.103
## 87  3226 46.16   2.962
## 88  3226 46.89   2.827
## 89  3226 47.47   2.699
## 90  3226 48.19   2.576
## 91  3226 48.91   2.459
## 92  3226 49.61   2.347
## 93  3226 50.31   2.241
## 94  3226 51.00   2.139
## 95  3226 51.69   2.042
## 96  3226 52.36   1.949
## 97  3226 53.03   1.860
## 98  3226 53.68   1.776
## 99  3226 54.33   1.695
## 100 3226 54.97   1.618

Cross-Validation

cv_results <- cv.glmnet(x, y,
                        family = "binomial",
                        nfolds = 10)
plot(cv_results)

cv_results
## 
## Call:  cv.glmnet(x = x, y = y, nfolds = 10, family = "binomial") 
## 
## Measure: Binomial Deviance 
## 
##      Lambda Index Measure      SE Nonzero
## min 0.06685    20   1.302 0.02499      18
## 1se 0.08838    14   1.322 0.01970       3
summary(lr_model)
##            Length Class     Mode     
## a0            100 -none-    numeric  
## beta       322600 dgCMatrix S4       
## df            100 -none-    numeric  
## dim             2 -none-    numeric  
## lambda        100 -none-    numeric  
## dev.ratio     100 -none-    numeric  
## nulldev         1 -none-    numeric  
## npasses         1 -none-    numeric  
## jerr            1 -none-    numeric  
## offset          1 -none-    logical  
## classnames      2 -none-    character
## call            5 -none-    call     
## nobs            1 -none-    numeric
best_lambda <- lr_model$lambda.min

# Refit the model with the selected lambda
best_model <- glmnet(x, y, family = "binomial", alpha = 0, lambda = best_lambda)

coef(best_model)[,1:12]
## 3227 x 12 sparse Matrix of class "dgCMatrix"
##   [[ suppressing 12 column names 's0', 's1', 's2' ... ]]
##                                                                    
## (Intercept) -1.249001e-16 -1.485397e-06 -1.713617e-06 -1.994138e-06
## ASV1236      3.133071e-38  1.908130e-04  1.998792e-04  2.089003e-04
## ASV0421     -5.547569e-38 -3.350813e-04 -3.510170e-04 -3.666903e-04
## ASV0691     -4.924975e-38 -2.896424e-04 -3.034079e-04 -3.165521e-04
## ASV0899     -1.324028e-39 -1.106490e-06 -1.150181e-06 -8.423284e-07
## ASV1004      6.299724e-38  3.812596e-04  3.993747e-04  4.172514e-04
## ASV1041     -4.258951e-38 -2.601709e-04 -2.725263e-04 -2.848550e-04
## ASV1058      5.855981e-38  3.551137e-04  3.719554e-04  3.886430e-04
## ASV12542     1.842670e-38  1.079264e-04  1.130596e-04  1.179279e-04
## ASV1294      6.764978e-38  4.142677e-04  4.339359e-04  4.536197e-04
## ASV13113     2.351661e-38  1.458535e-04  1.527909e-04  1.598135e-04
## ASV1318      5.929751e-38  3.623411e-04  3.795375e-04  3.967181e-04
## ASV2269     -1.761531e-38 -1.098832e-04 -1.150788e-04 -1.204113e-04
## ASV2542      3.703376e-38  2.338315e-04  2.449298e-04  2.564108e-04
## ASV2660     -3.447239e-38 -2.096052e-04 -2.195201e-04 -2.294065e-04
## ASV2737     -1.456066e-39 -1.367741e-05 -1.428706e-05 -1.518864e-05
## ASV2840      4.606802e-38  2.731776e-04  2.861168e-04  2.986311e-04
## ASV3053      2.609821e-39  1.393020e-05  1.460005e-05  1.514913e-05
## ASV3077      1.430712e-38  8.585485e-05  8.992082e-05  9.390237e-05
## ASV3134      4.753922e-38  2.982834e-04  3.124725e-04  3.270169e-04
## ASV3140      2.100119e-38  1.336623e-04  1.399884e-04  1.466031e-04
## ASV3579      7.918462e-39  5.166155e-05  5.415299e-05  5.676858e-05
## ASV6119     -1.761531e-38 -1.098826e-04 -1.150613e-04 -1.203916e-04
## ASV7557     -1.761531e-38 -1.098825e-04 -1.150525e-04 -1.203821e-04
## ASV8422      1.007031e-38  5.634432e-05  5.906750e-05  6.146692e-05
## ASV1086     -5.080525e-39 -2.910583e-05 -3.048988e-05 -3.176340e-05
## ASV1310      3.341700e-38  2.034198e-04  2.130823e-04  2.226822e-04
## ASV15750    -8.427200e-39 -5.330493e-05 -5.578787e-05 -5.841172e-05
## ASV16905    -1.761531e-38 -1.098822e-04 -1.150488e-04 -1.203771e-04
## ASV2033      3.219968e-38  1.981608e-04  2.076165e-04  2.170776e-04
## ASV2089      1.201683e-38  7.568921e-05  7.924489e-05  8.295371e-05
## ASV2127      4.826544e-38  2.909540e-04  3.047510e-04  3.183362e-04
## ASV2725      5.527505e-38  3.307507e-04  3.464588e-04  3.617712e-04
## ASV2804     -1.761531e-38 -1.098819e-04 -1.150462e-04 -1.203737e-04
## ASV3075      3.447315e-38  2.083974e-04  2.183021e-04  2.280642e-04
## ASV3327      3.161305e-38  1.954205e-04  2.047499e-04  2.141267e-04
## ASV3342      3.467863e-38  2.170442e-04  2.273305e-04  2.378866e-04
## ASV3532     -3.132836e-38 -1.949826e-04 -2.041960e-04 -2.136230e-04
## ASV3600      3.984828e-38  2.436328e-04  2.552341e-04  2.667875e-04
## ASV4013      3.390601e-38  2.047929e-04  2.145219e-04  2.241009e-04
## ASV4136      3.397772e-38  2.063844e-04  2.161372e-04  2.258593e-04
## ASV4195      1.761531e-38  1.098816e-04  1.150333e-04  1.203591e-04
## ASV4407     -1.761531e-38 -1.098815e-04 -1.150246e-04 -1.203496e-04
## ASV4717      1.290371e-39  2.551059e-06  2.738207e-06  2.584375e-06
## ASV6794      1.867634e-38  1.074894e-04  1.126327e-04  1.173874e-04
## ASV8324     -1.761531e-38 -1.098814e-04 -1.150221e-04 -1.203458e-04
## ASV8981     -5.080524e-39 -3.167254e-05 -3.309248e-05 -3.462509e-05
## ASV9859      1.271657e-38  8.098419e-05  8.489415e-05  8.890570e-05
## ASV0936     -2.763764e-38 -1.670378e-04 -1.749991e-04 -1.828183e-04
## ASV12683    -2.597726e-39 -1.968116e-05 -2.056413e-05 -2.169419e-05
## ASV1293      4.103429e-38  2.480806e-04  2.598015e-04  2.714219e-04
## ASV13055    -4.412996e-39 -2.855261e-05 -2.982406e-05 -3.125675e-05
## ASV17063    -1.761531e-38 -1.098810e-04 -1.150065e-04 -1.203283e-04
## ASV2228      1.761531e-38  1.098809e-04  1.149979e-04  1.203189e-04
## ASV2769     -3.595451e-39 -2.294309e-05 -2.394070e-05 -2.507630e-05
## ASV2803      8.703816e-39  4.729126e-05  4.959924e-05  5.153974e-05
## ASV2896      2.186891e-38  1.324738e-04  1.388159e-04  1.450406e-04
## ASV3062      6.184777e-39  3.940477e-05  4.135646e-05  4.330884e-05
## ASV3107      2.630824e-38  1.609503e-04  1.686230e-04  1.762622e-04
## ASV3265      5.341940e-38  3.213072e-04  3.364978e-04  3.514579e-04
## ASV3666     -1.114465e-39 -9.001639e-06 -9.355387e-06 -9.893566e-06
## ASV4497      1.264747e-38  7.556865e-05  7.920834e-05  8.270306e-05
## ASV6914     -6.022177e-39 -4.092110e-05 -4.279554e-05 -4.494452e-05
## ASV0576     -6.389199e-38 -3.785832e-04 -3.965166e-04 -4.138517e-04
## ASV0673      1.553071e-38  1.008247e-04  1.056149e-04  1.106971e-04
## ASV0772      1.888544e-38  1.124757e-04  1.178470e-04  1.230298e-04
## ASV0862     -1.577283e-38 -9.203229e-05 -9.637688e-05 -1.005122e-04
## ASV0898      1.494744e-38  9.645591e-05  1.010492e-04  1.058867e-04
## ASV0910      3.275872e-38  2.084996e-04  2.184185e-04  2.287337e-04
## ASV0964     -2.301490e-38 -1.374197e-04 -1.439205e-04 -1.502662e-04
## ASV10059     1.525478e-38  9.572315e-05  1.003210e-04  1.049947e-04
## ASV10263    -1.761531e-38 -1.098805e-04 -1.150437e-04 -1.203638e-04
## ASV1088      1.737606e-38  1.099024e-04  1.151404e-04  1.205475e-04
## ASV1101      3.039775e-38  1.861197e-04  1.949358e-04  2.037738e-04
## ASV1183      1.927595e-38  1.224131e-04  1.281763e-04  1.342157e-04
## ASV11956     8.034700e-39  4.304382e-05  4.512148e-05  4.685476e-05
## ASV12774    -2.459980e-39 -1.961180e-05 -2.050291e-05 -2.166437e-05
## ASV1321      7.011807e-39  4.626079e-05  4.851095e-05  5.088093e-05
## ASV13793    -1.761531e-38 -1.098803e-04 -1.150331e-04 -1.203513e-04
## ASV14482    -1.373377e-39 -1.250640e-05 -1.306283e-05 -1.386224e-05
## ASV15483     1.217911e-38  7.231745e-05  7.580862e-05  7.913316e-05
## ASV2062      7.731123e-38  4.751823e-04  4.976508e-04  5.203122e-04
## ASV2132      3.470506e-38  2.126693e-04  2.228237e-04  2.329410e-04
## ASV2413      5.051081e-38  3.050367e-04  3.194586e-04  3.337316e-04
## ASV2490      3.356463e-38  2.018648e-04  2.113825e-04  2.207810e-04
## ASV2594      1.808116e-38  1.084470e-04  1.136031e-04  1.186458e-04
## ASV2822     -1.761531e-38 -1.098802e-04 -1.150465e-04 -1.203640e-04
## ASV2863      3.096232e-38  1.890271e-04  1.979086e-04  2.068538e-04
## ASV2910      4.045912e-38  2.405403e-04  2.519731e-04  2.630313e-04
## ASV2980      1.459677e-38  9.109750e-05  9.536405e-05  9.977248e-05
## ASV3307      1.761531e-38  1.098801e-04  1.150317e-04  1.203474e-04
## ASV3474      2.664464e-38  1.679609e-04  1.759765e-04  1.842113e-04
## ASV3502      5.699692e-38  3.475411e-04  3.640307e-04  3.804674e-04
## ASV4236      2.952451e-38  1.762086e-04  1.844724e-04  1.926040e-04
## ASV4842     -9.516024e-39 -6.129490e-05 -6.417784e-05 -6.723812e-05
## ASV4894     -1.761531e-38 -1.098800e-04 -1.150410e-04 -1.203566e-04
## ASV5290      2.150314e-38  1.310240e-04  1.372811e-04  1.434766e-04
## ASV5501      4.076922e-39  2.364198e-05  2.476756e-05  2.582819e-05
## ASV5795      1.425114e-38  8.699871e-05  9.115383e-05  9.527840e-05
## ASV5987     -1.761531e-38 -1.098800e-04 -1.150439e-04 -1.203592e-04
## ASV6267     -1.761531e-38 -1.098799e-04 -1.150352e-04 -1.203498e-04
## ASV6862      3.472093e-38  2.049392e-04  2.146227e-04  2.239674e-04
## ASV7145      6.514140e-39  3.554432e-05  3.722396e-05  3.869644e-05
## ASV7673     -1.761531e-38 -1.098799e-04 -1.150327e-04 -1.203465e-04
## ASV7789      5.781709e-39  3.652998e-05  3.832847e-05  4.012932e-05
## ASV7809     -2.504185e-39 -1.615844e-05 -1.685826e-05 -1.765877e-05
## ASV8002     -1.761531e-38 -1.098798e-04 -1.150255e-04 -1.203385e-04
## ASV8205      1.018531e-38  5.796957e-05  6.078188e-05  6.331894e-05
## ASV9155     -1.330777e-38 -8.336974e-05 -8.725280e-05 -9.129843e-05
## ASV9221     -2.388223e-39 -1.750088e-05 -1.825110e-05 -1.922070e-05
## ASV9311     -1.761531e-38 -1.098798e-04 -1.150130e-04 -1.203241e-04
## ASV9557     -1.761531e-38 -1.098797e-04 -1.150043e-04 -1.203147e-04
## ASV9936     -1.761531e-38 -1.098797e-04 -1.149957e-04 -1.203052e-04
## ASV1445      3.997197e-38  2.472151e-04  2.589931e-04  2.708681e-04
## ASV4232      3.338541e-38  2.066920e-04  2.165692e-04  2.265191e-04
## ASV6479     -8.157800e-40 -2.493097e-06 -2.532985e-06 -2.507023e-06
## ASV0142     -9.010265e-38 -5.403408e-04 -5.658601e-04 -5.909421e-04
## ASV0378     -2.984397e-38 -1.778476e-04 -1.862181e-04 -1.944117e-04
## ASV1122      5.277825e-38  3.255943e-04  3.410660e-04  3.566641e-04
## ASV0123     -8.831622e-38 -5.296978e-04 -5.546679e-04 -5.792579e-04
## ASV2064      9.456684e-39  5.301739e-05  5.548838e-05  5.776865e-05
## ASV4459     -9.719539e-39 -6.191645e-05 -6.481169e-05 -6.786521e-05
## ASV0448      1.423142e-38  9.730411e-05  1.019918e-04  1.071318e-04
## ASV0397      3.967868e-38  2.464117e-04  2.581236e-04  2.699978e-04
## ASV0485      5.602948e-38  3.426509e-04  3.588641e-04  3.751107e-04
## ASV1566      4.654943e-38  2.831909e-04  2.966128e-04  3.099751e-04
## ASV1365      3.010399e-38  1.823497e-04  1.910279e-04  1.995947e-04
## ASV1065      6.170416e-38  3.797311e-04  3.976935e-04  4.158214e-04
## ASV0722     -1.470608e-39 -6.262697e-06 -6.580155e-06 -6.747648e-06
## ASV12660    -2.979446e-38 -1.821147e-04 -1.906855e-04 -1.993044e-04
## ASV0223     -1.235827e-39 -3.031397e-06 -3.188949e-06 -3.106707e-06
## ASV0229      2.730513e-38  1.712747e-04  1.794002e-04  1.877385e-04
## ASV0877     -1.108271e-38 -6.769687e-05 -7.078255e-05 -7.397489e-05
## ASV0983      5.740917e-38  3.500241e-04  3.665447e-04  3.830829e-04
## ASV0626     -1.988713e-38 -1.147856e-04 -1.200539e-04 -1.251382e-04
## ASV4146     -3.218327e-39 -2.169253e-05 -2.261841e-05 -2.373606e-05
## ASV4175     -3.481381e-38 -2.154629e-04 -2.255776e-04 -2.359138e-04
## ASV2082     -2.075558e-39 -1.215953e-05 -1.288176e-05 -1.344948e-05
## ASV2272      2.490583e-38  1.532060e-04  1.605229e-04  1.678489e-04
## ASV2245     -3.017452e-38 -1.869420e-04 -1.957014e-04 -2.046768e-04
## ASV0590     -1.761143e-38 -1.099843e-04 -1.153115e-04 -1.206595e-04
## ASV0217     -3.047970e-38 -1.700610e-04 -1.779596e-04 -1.851798e-04
## ASV0416      2.949399e-38  1.759130e-04  1.841390e-04  1.922388e-04
## ASV1056      3.274151e-38  2.065818e-04  2.165093e-04  2.266467e-04
## ASV7777     -3.002033e-38 -1.881333e-04 -1.969416e-04 -2.060851e-04
## ASV0455      5.747357e-39  3.878293e-05  4.053846e-05  4.255004e-05
## ASV0604      5.799389e-39  4.199783e-05  4.411789e-05  4.645530e-05
## ASV6100     -2.766616e-38 -1.747451e-04 -1.829192e-04 -1.914805e-04
## ASV11359    -3.118370e-38 -1.922464e-04 -2.012274e-04 -2.104055e-04
## ASV6604      2.173846e-38  1.362445e-04  1.427918e-04  1.494398e-04
## ASV5004     -1.832224e-38 -1.147961e-04 -1.201018e-04 -1.256695e-04
## ASV1483     -1.683076e-38 -1.048731e-04 -1.097285e-04 -1.147861e-04
## ASV9773     -3.550227e-38 -2.224048e-04 -2.328051e-04 -2.436099e-04
## ASV4059      2.938087e-39  2.166942e-05  2.278455e-05  2.401895e-05
## ASV1193      5.793652e-38  3.570573e-04  3.740185e-04  3.911103e-04
## ASV4610     -6.006542e-39 -3.358977e-05 -3.507643e-05 -3.649164e-05
## ASV0742     -2.298570e-38 -1.352354e-04 -1.414388e-04 -1.475650e-04
## ASV1502      8.007334e-41 -2.018574e-06 -2.048436e-06 -2.256775e-06
## ASV0195     -5.832160e-39 -3.817775e-05 -4.005520e-05 -4.200836e-05
## ASV1213      1.900259e-38  1.159335e-04  1.212323e-04  1.266999e-04
## ASV1648     -2.634404e-38 -1.651881e-04 -1.728848e-04 -1.809159e-04
## ASV6984     -1.961126e-38 -1.224858e-04 -1.281590e-04 -1.340814e-04
## ASV0396     -1.668481e-38 -8.824550e-05 -9.237634e-05 -9.586264e-05
## ASV4297      3.047471e-38  1.818746e-04  1.905123e-04  1.989174e-04
## ASV2622      6.888392e-38  4.157039e-04  4.353348e-04  4.547717e-04
## ASV3512      9.672295e-39  6.170919e-05  6.476444e-05  6.784317e-05
## ASV2411      2.270339e-38  1.436981e-04  1.504782e-04  1.575400e-04
## ASV2291     -5.441058e-39 -3.259435e-05 -3.430549e-05 -3.583662e-05
## ASV0807      2.604318e-38  1.710813e-04  1.792579e-04  1.879760e-04
## ASV1292      1.555548e-38  9.753626e-05  1.020515e-04  1.067900e-04
## ASV1035      7.560947e-39  4.426924e-05  4.631109e-05  4.829654e-05
## ASV0070     -1.712350e-38 -1.000053e-04 -1.046895e-04 -1.091994e-04
## ASV0255      6.544534e-39  3.876942e-05  4.054103e-05  4.229717e-05
## ASV0057     -7.196267e-38 -4.285801e-04 -4.487127e-04 -4.684465e-04
## ASV0077     -1.116893e-38 -6.375209e-05 -6.671409e-05 -6.951586e-05
## ASV0625      7.103019e-38  4.307026e-04  4.508887e-04  4.711143e-04
## ASV2464      3.477612e-38  2.107082e-04  2.205687e-04  2.304411e-04
## ASV1315      5.946957e-38  3.658819e-04  3.833229e-04  4.008168e-04
## ASV2673      4.308417e-38  2.728501e-04  2.858890e-04  2.993263e-04
## ASV2161      1.768595e-38  1.106146e-04  1.159388e-04  1.213288e-04
## ASV0337     -2.931708e-38 -1.804013e-04 -1.889920e-04 -1.976186e-04
## ASV7680     -3.404884e-38 -2.109050e-04 -2.207863e-04 -2.309086e-04
## ASV0611      7.352171e-38  4.551899e-04  4.768399e-04  4.987329e-04
## ASV3118     -2.500910e-38 -1.563259e-04 -1.636630e-04 -1.712368e-04
## ASV1284      2.644200e-38  1.698133e-04  1.777015e-04  1.861399e-04
## ASV0889      2.055484e-38  1.240192e-04  1.299302e-04  1.357367e-04
## ASV4649     -2.121874e-38 -1.334350e-04 -1.396531e-04 -1.461570e-04
## ASV1108     -2.641951e-38 -1.691723e-04 -1.771590e-04 -1.855655e-04
## ASV0738     -5.908183e-39 -2.232608e-05 -2.328415e-05 -2.363166e-05
## ASV0473      4.155210e-39  2.651319e-05  2.771962e-05  2.902249e-05
## ASV0598     -3.187637e-38 -1.903784e-04 -1.993192e-04 -2.081112e-04
## ASV0429      4.956004e-38  3.021205e-04  3.163934e-04  3.306756e-04
## ASV1549      4.785423e-38  3.029638e-04  3.174044e-04  3.323198e-04
## ASV1203      3.731441e-38  2.270297e-04  2.376808e-04  2.483789e-04
## ASV4532      1.922455e-39  9.742039e-06  1.024191e-05  1.061446e-05
## ASV0274     -3.852814e-38 -2.268601e-04 -2.375678e-04 -2.478942e-04
## ASV0163     -5.515623e-38 -3.265723e-04 -3.417881e-04 -3.567216e-04
## ASV1298      2.242946e-38  1.335094e-04  1.396940e-04  1.458234e-04
## ASV9424     -4.497007e-38 -2.815765e-04 -2.948104e-04 -3.084882e-04
## ASV0412      7.043598e-38  4.306329e-04  4.509837e-04  4.713910e-04
## ASV0284      3.217293e-38  1.916966e-04  2.006555e-04  2.094713e-04
## ASV0620     -2.264305e-38 -1.449064e-04 -1.517342e-04 -1.589238e-04
## ASV0153     -4.777492e-38 -2.976247e-04 -3.118823e-04 -3.262996e-04
## ASV0498      3.908578e-39  3.356086e-05  3.518858e-05  3.726213e-05
## ASV0097      3.406348e-38  2.116342e-04  2.216571e-04  2.318627e-04
## ASV0104     -1.612636e-37 -9.866334e-04 -1.033436e-03 -1.080279e-03
## ASV1282      2.775381e-38  1.740438e-04  1.823287e-04  1.908023e-04
## ASV3883     -1.582262e-38 -9.739174e-05 -1.019674e-04 -1.066007e-04
## ASV0801      1.543506e-38  1.024593e-04  1.072369e-04  1.125044e-04
## ASV1611     -6.138811e-38 -3.785988e-04 -3.964315e-04 -4.145358e-04
## ASV0227     -2.145864e-38 -1.339951e-04 -1.404496e-04 -1.469582e-04
## ASV0833      2.307460e-38  1.483528e-04  1.554610e-04  1.628793e-04
## ASV0718      5.752412e-38  3.576295e-04  3.745335e-04  3.917943e-04
## ASV1139      2.218115e-38  1.345399e-04  1.407152e-04  1.470250e-04
## ASV0766     -1.602961e-38 -9.573937e-05 -1.001708e-04 -1.045799e-04
## ASV2091      7.916680e-38  4.728297e-04  4.950704e-04  5.169244e-04
## ASV1238     -5.836449e-39 -2.519539e-05 -2.627115e-05 -2.693708e-05
## ASV9193     -6.133051e-39 -5.058371e-05 -5.289709e-05 -5.592828e-05
## ASV0290     -5.878822e-39 -3.657106e-05 -3.830559e-05 -4.006726e-05
## ASV0231      6.145335e-38  3.730930e-04  3.906422e-04  4.081818e-04
## ASV0185      8.140561e-39  6.997178e-05  7.346040e-05  7.781979e-05
## ASV2330      1.801334e-38  1.085559e-04  1.136958e-04  1.187700e-04
## ASV3119     -1.890145e-38 -1.245015e-04 -1.304466e-04 -1.368032e-04
## ASV2368     -2.727240e-38 -1.731298e-04 -1.812513e-04 -1.897805e-04
## ASV0122     -2.266189e-38 -1.366210e-04 -1.431297e-04 -1.495280e-04
## ASV1044      3.693122e-38  2.377824e-04  2.491504e-04  2.610585e-04
## ASV0160     -5.622767e-38 -3.319708e-04 -3.474935e-04 -3.626340e-04
## ASV0326      3.500982e-38  2.150877e-04  2.253922e-04  2.356572e-04
## ASV1388      6.164818e-38  3.768329e-04  3.946614e-04  4.125324e-04
## ASV0792      7.055394e-38  4.321274e-04  4.524060e-04  4.729240e-04
## ASV0036     -4.341619e-38 -2.723864e-04 -2.854195e-04 -2.987115e-04
## ASV2125      7.212501e-38  4.432122e-04  4.641907e-04  4.853310e-04
## ASV1075      1.338293e-38  8.438700e-05  8.845959e-05  9.261097e-05
## ASV0390      1.253755e-38  8.649706e-05  9.062149e-05  9.523436e-05
## ASV3790     -5.735622e-38 -3.478524e-04 -3.642354e-04 -3.805749e-04
## ASV1535     -4.340024e-39 -2.934157e-05 -3.072865e-05 -3.224505e-05
## ASV0263      1.187358e-38  7.549861e-05  7.900468e-05  8.272450e-05
## ASV0675      9.307161e-38  5.869000e-04  6.147258e-04  6.434752e-04
## ASV3348      8.656278e-39  5.676206e-05  5.957709e-05  6.248220e-05
## ASV0058     -9.122278e-38 -5.542065e-04 -5.803912e-04 -6.065049e-04
## ASV4142      2.292079e-38  1.369338e-04  1.433300e-04  1.496676e-04
## ASV0059     -7.879787e-38 -4.778106e-04 -5.003371e-04 -5.228036e-04
## ASV0013     -1.637259e-37 -1.000529e-03 -1.047869e-03 -1.095306e-03
## ASV0033     -4.719255e-38 -2.970738e-04 -3.112448e-04 -3.257886e-04
## ASV4354     -2.135964e-38 -1.289855e-04 -1.350251e-04 -1.410479e-04
## ASV0022     -4.986826e-38 -3.137377e-04 -3.286692e-04 -3.440166e-04
## ASV0134     -1.193838e-38 -7.946790e-05 -8.328511e-05 -8.740127e-05
## ASV0415     -1.175890e-38 -6.524544e-05 -6.823674e-05 -7.099703e-05
## ASV10103    -3.511087e-38 -2.175841e-04 -2.277866e-04 -2.382407e-04
## ASV1613      5.799264e-38  3.544322e-04  3.711184e-04  3.879239e-04
## ASV0135     -4.478038e-39 -2.235386e-05 -2.327640e-05 -2.407412e-05
## ASV0469     -7.254312e-38 -4.407074e-04 -4.613551e-04 -4.821060e-04
## ASV0471      4.519901e-38  2.830636e-04  2.964070e-04  3.101684e-04
## ASV0451     -1.173322e-38 -7.552499e-05 -7.920357e-05 -8.299647e-05
## ASV0747      1.684687e-38  1.052262e-04  1.102585e-04  1.153612e-04
## ASV1314     -2.604417e-38 -1.672703e-04 -1.751952e-04 -1.835350e-04
## ASV0425     -8.316441e-38 -4.982203e-04 -5.215712e-04 -5.446734e-04
## ASV0559     -4.740023e-38 -2.809371e-04 -2.940871e-04 -3.069570e-04
## ASV0148     -5.151179e-38 -3.068554e-04 -3.212242e-04 -3.353670e-04
## ASV0129     -2.643876e-38 -1.527733e-04 -1.598546e-04 -1.666589e-04
## ASV1072      2.514587e-38  1.478164e-04  1.547157e-04  1.614246e-04
## ASV2390      1.792174e-38  1.074626e-04  1.125188e-04  1.175095e-04
## ASV0548      5.195657e-38  3.228210e-04  3.381586e-04  3.537505e-04
## ASV0168     -7.970435e-38 -4.809453e-04 -5.035387e-04 -5.260302e-04
## ASV0066     -5.880654e-38 -3.604353e-04 -3.774670e-04 -3.946142e-04
## ASV0468     -2.156339e-38 -1.374983e-04 -1.439289e-04 -1.507360e-04
## ASV0172     -1.376210e-38 -7.536357e-05 -7.876430e-05 -8.189823e-05
## ASV0236     -3.246804e-38 -1.848785e-04 -1.933480e-04 -2.014219e-04
## ASV0250     -7.781599e-40  1.064916e-05  1.140286e-05  1.269085e-05
## ASV0338     -5.609719e-39 -2.150292e-05 -2.234912e-05 -2.272022e-05
## ASV0450     -2.980329e-40  6.505922e-07  6.766473e-07  8.291404e-07
## ASV0377      6.423902e-38  3.962228e-04  4.149100e-04  4.338702e-04
## ASV1022      1.776651e-38  1.123895e-04  1.176451e-04  1.231639e-04
## ASV6174     -4.557312e-39 -2.519413e-05 -2.636194e-05 -2.740783e-05
## ASV0786      7.561788e-39  4.544168e-05  4.753804e-05  4.964216e-05
## ASV0053     -7.710100e-38 -4.754753e-04 -4.979594e-04 -5.207254e-04
## ASV0697     -2.322761e-38 -1.374339e-04 -1.438288e-04 -1.501183e-04
## ASV0785      5.747145e-38  3.534627e-04  3.701702e-04  3.870603e-04
## ASV1967     -3.902972e-38 -2.362602e-04 -2.473833e-04 -2.584532e-04
## ASV0385     -1.854378e-38 -1.077010e-04 -1.127121e-04 -1.175483e-04
## ASV0295     -1.077806e-39 -5.647932e-07 -4.648935e-07 -1.809315e-07
## ASV0072     -6.300848e-38 -3.784808e-04 -3.961695e-04 -4.137835e-04
## ASV0157     -2.674913e-38 -1.542215e-04 -1.613766e-04 -1.682018e-04
## ASV0501      2.719653e-38  1.747943e-04  1.831613e-04  1.918597e-04
## ASV10729    -4.667636e-38 -2.907864e-04 -3.044920e-04 -3.185484e-04
## ASV1470      2.276183e-38  1.302711e-04  1.363659e-04  1.421027e-04
## ASV0050     -1.552864e-37 -9.448499e-04 -9.892959e-04 -1.033872e-03
## ASV0411     -4.571970e-39 -2.609942e-05 -2.726019e-05 -2.841990e-05
## ASV0549      2.846724e-38  1.803219e-04  1.889698e-04  1.978668e-04
## ASV0184      1.803143e-38  1.117796e-04  1.170233e-04  1.223970e-04
## ASV0705      2.127130e-38  1.358633e-04  1.423210e-04  1.490552e-04
## ASV1715      5.451392e-38  3.361116e-04  3.519646e-04  3.680526e-04
## ASV0603      6.303247e-39  4.262458e-05  4.460868e-05  4.683957e-05
## ASV0826      1.883618e-38  1.125511e-04  1.178142e-04  1.230145e-04
## ASV0034     -7.066366e-38 -4.294520e-04 -4.495333e-04 -4.697594e-04
## ASV0838      1.483163e-38  1.002198e-04  1.048840e-04  1.101080e-04
## ASV0614     -4.004712e-38 -2.483288e-04 -2.600223e-04 -2.719717e-04
## ASV0014     -1.504048e-37 -9.164003e-04 -9.594518e-04 -1.002748e-03
## ASV0585     -9.271648e-39 -5.332300e-05 -5.586263e-05 -5.822703e-05
## ASV0016     -1.536910e-37 -9.371017e-04 -9.810617e-04 -1.025367e-03
## ASV5394     -3.851025e-38 -2.406006e-04 -2.519566e-04 -2.636239e-04
## ASV0666      3.316568e-38  2.036369e-04  2.131640e-04  2.228547e-04
## ASV2085      1.443304e-38  8.064250e-05  8.424797e-05  8.768162e-05
## ASV0003     -1.408628e-37 -8.572970e-04 -8.974133e-04 -9.378609e-04
## ASV0346     -4.125123e-39 -1.569904e-05 -1.620287e-05 -1.645486e-05
## ASV0267     -2.302057e-38 -1.395672e-04 -1.459292e-04 -1.524801e-04
## ASV0353      2.834266e-38  1.857057e-04  1.946516e-04  2.040786e-04
## ASV2419      3.995432e-38  2.432256e-04  2.546035e-04  2.660830e-04
## ASV0447      1.710637e-38  1.149951e-04  1.206314e-04  1.266216e-04
## ASV0654      6.042853e-38  3.734896e-04  3.912007e-04  4.091166e-04
## ASV0151      8.512835e-39  5.777364e-05  6.070237e-05  6.374678e-05
## ASV0065     -5.669201e-38 -3.461521e-04 -3.624201e-04 -3.788220e-04
## ASV0527      4.097663e-38  2.533188e-04  2.652083e-04  2.773626e-04
## ASV4055     -1.480477e-38 -9.879033e-05 -1.035023e-04 -1.086177e-04
## ASV0166     -4.804275e-38 -2.823246e-04 -2.954621e-04 -3.082732e-04
## ASV0417     -4.017932e-38 -2.434224e-04 -2.548098e-04 -2.662381e-04
## ASV0078     -3.257390e-38 -1.951716e-04 -2.042386e-04 -2.132946e-04
## ASV0322     -3.965370e-38 -2.336693e-04 -2.445123e-04 -2.551464e-04
## ASV0156     -5.105976e-38 -3.021854e-04 -3.163015e-04 -3.301289e-04
## ASV0648     -4.488601e-38 -2.815331e-04 -2.948211e-04 -3.085289e-04
## ASV0407      3.103441e-39  1.594673e-05  1.675379e-05  1.736664e-05
## ASV2030     -1.031307e-38 -5.908804e-05 -6.186487e-05 -6.445575e-05
## ASV0300      2.546967e-38  1.675588e-04  1.756450e-04  1.841924e-04
## ASV1150     -3.852651e-39 -2.388806e-05 -2.492285e-05 -2.606333e-05
## ASV0958      2.664002e-38  1.720983e-04  1.803443e-04  1.889883e-04
## ASV0216     -4.906846e-38 -2.970148e-04 -3.107864e-04 -3.247076e-04
## ASV0446      6.489840e-38  4.110993e-04  4.306435e-04  4.508679e-04
## ASV0367     -2.295717e-38 -1.401058e-04 -1.466756e-04 -1.533092e-04
## ASV0200     -4.250453e-38 -2.571906e-04 -2.693018e-04 -2.813762e-04
## ASV0334     -2.377183e-38 -1.312540e-04 -1.371040e-04 -1.425932e-04
## ASV1311      3.031849e-38  1.901085e-04  1.989691e-04  2.082250e-04
## ASV0458      3.264472e-38  1.999219e-04  2.093654e-04  2.188590e-04
## ASV1371      9.212320e-40  3.311521e-06  3.485371e-06  3.524488e-06
## ASV0418      3.956423e-38  2.356465e-04  2.467002e-04  2.575574e-04
## ASV0004      4.709975e-38  2.863350e-04  2.998219e-04  3.133206e-04
## ASV1943      3.491045e-38  2.102337e-04  2.201953e-04  2.300059e-04
## ASV1495     -7.505106e-39 -5.146573e-05 -5.406239e-05 -5.680020e-05
## ASV0901     -5.270082e-38 -3.303631e-04 -3.460542e-04 -3.621541e-04
## ASV0628      3.182044e-38  1.948186e-04  2.038882e-04  2.131387e-04
## ASV0400      1.272268e-38  7.663183e-05  8.019290e-05  8.375242e-05
## ASV0116     -4.015755e-38 -2.468226e-04 -2.585522e-04 -2.703340e-04
## ASV0788      3.388298e-38  2.078331e-04  2.176368e-04  2.275228e-04
## ASV0117      2.104939e-38  1.337443e-04  1.401655e-04  1.467727e-04
## ASV3137      6.088051e-39  3.718533e-05  3.894216e-05  4.070913e-05
## ASV0001      5.769339e-38  3.493623e-04  3.656093e-04  3.820059e-04
## ASV1651      3.849282e-38  2.243828e-04  2.347810e-04  2.448570e-04
## ASV1692      3.916604e-38  2.479499e-04  2.597708e-04  2.719704e-04
## ASV0660      2.398237e-38  1.418857e-04  1.483790e-04  1.548412e-04
## ASV0508      3.230712e-39  1.886343e-05  1.973699e-05  2.058756e-05
## ASV1660     -1.583265e-38 -1.002010e-04 -1.050158e-04 -1.099384e-04
## ASV0233      8.806217e-39  5.639613e-05  5.912351e-05  6.193602e-05
## ASV1343     -4.010104e-38 -2.485290e-04 -2.602738e-04 -2.722284e-04
## ASV0209      3.847575e-38  2.347029e-04  2.455844e-04  2.566824e-04
## ASV0193     -4.956363e-38 -2.925623e-04 -3.061270e-04 -3.194692e-04
## ASV0357     -3.708285e-39 -2.267140e-05 -2.360777e-05 -2.467155e-05
## ASV0198      1.029473e-38  6.674760e-05  6.990145e-05  7.325478e-05
## ASV0007      5.469502e-38  3.317701e-04  3.471736e-04  3.627726e-04
## ASV1772     -5.550091e-39 -3.281374e-05 -3.434175e-05 -3.583937e-05
## ASV0009      5.167512e-38  3.133806e-04  3.278948e-04  3.426243e-04
## ASV0006      2.157679e-38  1.261948e-04  1.319045e-04  1.375939e-04
## ASV0011     -5.581552e-38 -3.476957e-04 -3.641205e-04 -3.809398e-04
## ASV0015      3.953436e-38  2.412701e-04  2.526181e-04  2.640382e-04
## ASV0017      4.193162e-38  2.555755e-04  2.675563e-04  2.796364e-04
## ASV0235     -3.262141e-38 -2.010908e-04 -2.105931e-04 -2.202013e-04
## ASV0382      4.625552e-39  3.805427e-05  4.008780e-05  4.239018e-05
## ASV2357      4.986866e-38  3.066749e-04  3.211235e-04  3.357566e-04
## ASV0567     -3.682815e-38 -2.245209e-04 -2.349885e-04 -2.456043e-04
## ASV0165      3.988685e-38  2.466771e-04  2.583012e-04  2.701330e-04
## ASV0005      8.107507e-38  4.899131e-04  5.127984e-04  5.357282e-04
## ASV0384     -4.532717e-39 -2.635055e-05 -2.744689e-05 -2.862139e-05
## ASV0002      1.659396e-38  1.033754e-04  1.083457e-04  1.133524e-04
## ASV3017      4.757079e-38  2.871443e-04  3.004565e-04  3.138786e-04
## ASV0091      1.764900e-38  1.099225e-04  1.151344e-04  1.204472e-04
## ASV0186     -4.797272e-38 -2.936992e-04 -3.075268e-04 -3.214729e-04
## ASV0370      4.710406e-39  3.179425e-05  3.326827e-05  3.493503e-05
## ASV0018      8.430121e-38  5.103113e-04  5.341430e-04  5.580739e-04
## ASV1377      7.378245e-38  4.483244e-04  4.692403e-04  4.903403e-04
## ASV0019      8.439473e-38  5.110415e-04  5.348692e-04  5.588407e-04
## ASV0023      7.066716e-39  3.723640e-05  3.870266e-05  4.015744e-05
## ASV2194      2.682544e-38  1.645285e-04  1.723438e-04  1.801905e-04
## ASV1155     -3.632665e-39 -1.644269e-05 -1.693904e-05 -1.741689e-05
## ASV0510     -3.222010e-38 -1.850802e-04 -1.933826e-04 -2.015493e-04
## ASV2371     -3.120574e-38 -1.855876e-04 -1.943048e-04 -2.028284e-04
## ASV0024      3.056467e-39  1.258259e-05  1.288875e-05  1.316739e-05
## ASV2452      4.023230e-38  2.423734e-04  2.535075e-04  2.648100e-04
## ASV2332      7.898870e-40  4.454049e-06  4.687266e-06  4.896315e-06
## ASV2591      5.921995e-40  9.353665e-06  9.817209e-06  1.056111e-05
## ASV0521      5.271635e-38  3.356814e-04  3.516266e-04  3.682314e-04
## ASV5542      1.600784e-38  1.007314e-04  1.054130e-04  1.103369e-04
## ASV0336     -2.531440e-38 -1.487600e-04 -1.556989e-04 -1.624494e-04
## ASV10102     3.682342e-38  2.273599e-04  2.380547e-04  2.489446e-04
## ASV16823    -3.040027e-38 -1.816058e-04 -1.901545e-04 -1.985402e-04
## ASV3104      3.040027e-38  1.816058e-04  1.901401e-04  1.985254e-04
## ASV0781      1.428856e-38  8.978916e-05  9.392981e-05  9.830947e-05
## ASV10899     1.253085e-38  8.251082e-05  8.648541e-05  9.070610e-05
## ASV11222    -3.040027e-38 -1.816057e-04 -1.901301e-04 -1.985155e-04
## ASV11327    -3.040027e-38 -1.816057e-04 -1.901157e-04 -1.985007e-04
## ASV12458    -3.040027e-38 -1.816057e-04 -1.901014e-04 -1.984859e-04
## ASV1636     -2.490636e-38 -1.473258e-04 -1.541186e-04 -1.608421e-04
## ASV1890     -3.007323e-38 -1.802957e-04 -1.887430e-04 -1.971024e-04
## ASV2898      6.377943e-38  3.901464e-04  4.083080e-04  4.268041e-04
## ASV8328     -6.226076e-39 -3.074176e-05 -3.205837e-05 -3.313068e-05
## ASV0709     -5.198536e-38 -3.162657e-04 -3.309510e-04 -3.458579e-04
## ASV0856      7.771543e-39  5.220046e-05  5.469911e-05  5.741924e-05
## ASV0909     -2.335561e-38 -1.332493e-04 -1.391533e-04 -1.449715e-04
## ASV0937     -4.008191e-38 -2.468551e-04 -2.585640e-04 -2.703633e-04
## ASV11390    -3.040027e-38 -1.816057e-04 -1.900705e-04 -1.984544e-04
## ASV11966     1.420327e-38  8.864796e-05  9.287905e-05  9.717595e-05
## ASV12990     7.819545e-39  4.991026e-05  5.218436e-05  5.465849e-05
## ASV14797     3.089629e-38  1.876378e-04  1.962542e-04  2.050778e-04
## ASV14904    -3.040027e-38 -1.816057e-04 -1.900659e-04 -1.984501e-04
## ASV15304     7.030854e-39  4.543215e-05  4.763947e-05  4.992105e-05
## ASV16696    -3.040027e-38 -1.816057e-04 -1.900538e-04 -1.984376e-04
## ASV1690      1.419706e-38  9.174082e-05  9.617471e-05  1.007830e-04
## ASV2029      8.151639e-38  4.991662e-04  5.224501e-04  5.461442e-04
## ASV2834      4.329441e-38  2.644228e-04  2.768741e-04  2.893921e-04
## ASV4003      1.121142e-38  7.697683e-05  8.073933e-05  8.483649e-05
## ASV4064      2.989265e-38  1.823310e-04  1.909140e-04  1.995361e-04
## ASV4294      9.589711e-39  6.612541e-05  6.935098e-05  7.288309e-05
## ASV4609     -1.530065e-39 -8.970031e-06 -9.447212e-06 -9.848408e-06
## ASV6283     -3.040027e-38 -1.816056e-04 -1.900507e-04 -1.984353e-04
## ASV6491     -3.040027e-38 -1.816056e-04 -1.900364e-04 -1.984205e-04
## ASV7453      1.059821e-38  7.131683e-05  7.478970e-05  7.850883e-05
## ASV7959      1.319226e-39  1.211791e-05  1.278039e-05  1.356726e-05
## ASV8219      3.040027e-38  1.816056e-04  1.900260e-04  1.984100e-04
## ASV8547     -3.040027e-38 -1.816055e-04 -1.900118e-04 -1.983952e-04
## ASV9319      1.938115e-38  1.192701e-04  1.248803e-04  1.305739e-04
## ASV9382     -3.040027e-38 -1.816055e-04 -1.900028e-04 -1.983858e-04
## ASV11516    -3.040027e-38 -1.816055e-04 -1.899886e-04 -1.983710e-04
## ASV14377    -3.040027e-38 -1.816055e-04 -1.899745e-04 -1.983562e-04
## ASV1867      4.243133e-38  2.644953e-04  2.769743e-04  2.897777e-04
## ASV1895     -1.045979e-38 -6.231039e-05 -6.513977e-05 -6.800805e-05
## ASV3168      1.850837e-38  1.116336e-04  1.167676e-04  1.219766e-04
## ASV4449      3.739630e-38  2.256396e-04  2.361050e-04  2.466407e-04
## ASV6596      1.994017e-38  1.316071e-04  1.379751e-04  1.447298e-04
## ASV7492     -1.214220e-38 -6.866030e-05 -7.167701e-05 -7.463527e-05
## ASV9854     -1.586802e-38 -9.325314e-05 -9.752740e-05 -1.017487e-04
## ASV6296      3.040027e-38  1.816054e-04  1.899442e-04  1.983249e-04
## ASV4201      8.213575e-39  5.835409e-05  6.136111e-05  6.456077e-05
## ASV0552      7.091608e-38  4.432578e-04  4.642355e-04  4.857454e-04
## ASV3671     -6.933592e-39 -3.624613e-05 -3.779886e-05 -3.919287e-05
## ASV3529     -7.618069e-39 -4.203533e-05 -4.379078e-05 -4.554131e-05
## ASV1060      1.780419e-38  1.129075e-04  1.182714e-04  1.238409e-04
## ASV0239     -4.212994e-38 -2.473585e-04 -2.586896e-04 -2.698806e-04
## ASV5711     -3.858562e-38 -2.315608e-04 -2.422552e-04 -2.530004e-04
## ASV4152     -5.028716e-38 -3.038987e-04 -3.180465e-04 -3.322610e-04
## ASV1461      4.545945e-38  2.727193e-04  2.852235e-04  2.978739e-04
## ASV2877      3.640261e-38  2.205385e-04  2.308062e-04  2.411530e-04
## ASV0012      2.642182e-38  1.646279e-04  1.725240e-04  1.804946e-04
## ASV9823      1.022522e-38  5.273385e-05  5.510182e-05  5.712244e-05
## ASV0008      2.903262e-38  1.799787e-04  1.885585e-04  1.972246e-04
## ASV7832     -3.117744e-38 -1.892889e-04 -1.980640e-04 -2.069603e-04
## ASV1915      1.884721e-39  1.453690e-05  1.533166e-05  1.617929e-05
## ASV0055      2.110467e-38  1.295340e-04  1.356041e-04  1.417693e-04
## ASV0032      5.174495e-38  3.182277e-04  3.329563e-04  3.481348e-04
## ASV2977     -4.236458e-38 -2.561868e-04 -2.680906e-04 -2.800792e-04
## ASV0466      4.341784e-38  2.584954e-04  2.703848e-04  2.822701e-04
## ASV3866      4.428837e-38  2.757829e-04  2.887837e-04  3.021166e-04
## ASV0040      5.852469e-38  3.618329e-04  3.789791e-04  3.963430e-04
## ASV0496     -2.206917e-39 -2.025217e-05 -2.142206e-05 -2.273831e-05
## ASV0052      7.282631e-38  4.427894e-04  4.634220e-04  4.842789e-04
## ASV3828     -4.522951e-38 -2.767072e-04 -2.895403e-04 -3.026624e-04
## ASV1930      2.768340e-38  1.724932e-04  1.806022e-04  1.889419e-04
## ASV2126      4.533398e-38  2.786916e-04  2.917079e-04  3.049967e-04
## ASV0793      2.607435e-38  1.624860e-04  1.703365e-04  1.782080e-04
## ASV0299     -2.003054e-38 -1.163024e-04 -1.215117e-04 -1.266928e-04
## ASV0208      4.123216e-38  2.638663e-04  2.764347e-04  2.895538e-04
## ASV0511     -2.426196e-38 -1.401264e-04 -1.463814e-04 -1.525897e-04
## ASV1123     -3.131395e-38 -1.832762e-04 -1.916147e-04 -1.998735e-04
## ASV0099     -1.685390e-38 -9.831966e-05 -1.028649e-04 -1.072793e-04
## ASV0752     -2.883957e-39 -2.132435e-05 -2.242819e-05 -2.363655e-05
## ASV0883      1.221272e-40  1.167877e-06  1.268838e-06  1.350132e-06
## ASV0683      3.687287e-38  2.341418e-04  2.452850e-04  2.568434e-04
## ASV4117     -4.545179e-38 -2.736963e-04 -2.863986e-04 -2.991478e-04
## ASV2172      1.665364e-38  1.022156e-04  1.070225e-04  1.118956e-04
## ASV0330     -3.022947e-38 -1.872858e-04 -1.961016e-04 -2.051206e-04
## ASV0728      2.813973e-38  1.682685e-04  1.762921e-04  1.840882e-04
## ASV0499      5.569071e-38  3.540901e-04  3.709364e-04  3.884399e-04
## ASV0120     -6.313502e-38 -3.869041e-04 -4.050074e-04 -4.233847e-04
## ASV1446      6.044190e-39  3.293011e-05  3.431087e-05  3.565411e-05
## ASV17171    -4.305784e-38 -2.631985e-04 -2.754397e-04 -2.879063e-04
## ASV0533      1.169723e-38  7.505609e-05  7.866155e-05  8.240212e-05
## ASV2495     -1.703725e-38 -1.051715e-04 -1.101609e-04 -1.152012e-04
## ASV5582      1.573573e-38  9.156779e-05  9.569328e-05  9.979612e-05
## ASV1488      1.333731e-38  9.229115e-05  9.668644e-05  1.015874e-04
## ASV0682      3.878487e-38  2.469472e-04  2.586897e-04  2.709064e-04
## ASV0068     -1.569197e-39 -1.327735e-05 -1.407600e-05 -1.489705e-05
## ASV1987     -2.040273e-38 -1.306435e-04 -1.369790e-04 -1.434865e-04
## ASV0035      8.741778e-39  4.712766e-05  4.904687e-05  5.093719e-05
## ASV7192     -2.954758e-38 -1.754259e-04 -1.834718e-04 -1.915077e-04
## ASV0873      4.983130e-39  2.665061e-05  2.774500e-05  2.880668e-05
## ASV4749      3.649700e-39  1.724434e-05  1.777253e-05  1.831644e-05
## ASV2174      2.827707e-38  1.612881e-04  1.686144e-04  1.756886e-04
## ASV1476     -2.364743e-38 -1.437480e-04 -1.504985e-04 -1.572720e-04
## ASV0740     -5.655336e-38 -3.553192e-04 -3.721970e-04 -3.895430e-04
## ASV0170      1.225668e-38  7.571096e-05  7.925957e-05  8.288978e-05
## ASV2466     -5.252633e-38 -3.241162e-04 -3.392566e-04 -3.547737e-04
## ASV1709      4.103967e-38  2.498180e-04  2.614230e-04  2.732038e-04
## ASV6170     -3.701779e-38 -2.128933e-04 -2.229287e-04 -2.323773e-04
## ASV3673      4.233390e-38  2.539371e-04  2.659118e-04  2.777301e-04
## ASV1745      3.214905e-39  1.590267e-05  1.665546e-05  1.723721e-05
## ASV0380     -3.001704e-38 -1.700805e-04 -1.780522e-04 -1.854702e-04
## ASV0426     -9.429897e-39 -5.168855e-05 -5.416699e-05 -5.631987e-05
## ASV0202     -1.061039e-38 -5.271781e-05 -5.478559e-05 -5.664562e-05
## ASV6350     -3.682451e-38 -2.137760e-04 -2.238166e-04 -2.334157e-04
## ASV0713     -2.510054e-38 -1.523945e-04 -1.595707e-04 -1.667508e-04
## ASV1822      4.504880e-39  3.015101e-05  3.152317e-05  3.306624e-05
## ASV4569      4.087268e-38  2.466144e-04  2.581365e-04  2.696747e-04
## ASV0030     -8.372670e-39 -5.483193e-05 -5.756273e-05 -6.034441e-05
## ASV0331      1.553491e-38  1.020945e-04  1.070113e-04  1.122253e-04
## ASV2981      3.971736e-38  2.500761e-04  2.618795e-04  2.740955e-04
## ASV0828     -2.616058e-38 -1.666931e-04 -1.746126e-04 -1.828580e-04
## ASV2440      6.289782e-38  3.958041e-04  4.145137e-04  4.338545e-04
## ASV3006     -3.040027e-38 -1.725744e-04 -1.806531e-04 -1.881999e-04
## ASV3875     -3.040027e-38 -1.725743e-04 -1.806396e-04 -1.881867e-04
## ASV4511      1.544893e-38  9.942746e-05  1.041744e-04  1.091458e-04
## ASV4700     -3.040027e-38 -1.725742e-04 -1.806263e-04 -1.881735e-04
## ASV5804     -3.040027e-38 -1.725741e-04 -1.806128e-04 -1.881603e-04
## ASV6826      2.879466e-38  1.833668e-04  1.920604e-04  2.011338e-04
## ASV7280      2.393345e-38  1.516116e-04  1.587731e-04  1.662065e-04
## ASV7535     -3.040027e-38 -1.725739e-04 -1.806052e-04 -1.881535e-04
## ASV0651     -2.961384e-38 -1.785018e-04 -1.866562e-04 -1.949689e-04
## ASV0913      3.794294e-38  2.397244e-04  2.510837e-04  2.628591e-04
## ASV10832    -3.040027e-38 -1.725738e-04 -1.805924e-04 -1.881409e-04
## ASV1117     -5.631066e-38 -3.409692e-04 -3.569841e-04 -3.729978e-04
## ASV11329     1.146426e-38  8.313713e-05  8.723193e-05  9.183052e-05
## ASV13209    -3.629118e-39 -1.101355e-05 -1.144232e-05 -1.143216e-05
## ASV1345      6.318447e-39  4.167074e-05  4.371111e-05  4.581998e-05
## ASV1719     -3.040027e-38 -1.725736e-04 -1.805710e-04 -1.881204e-04
## ASV1886      3.242222e-38  1.968181e-04  2.060046e-04  2.152857e-04
## ASV2158     -9.398753e-39 -4.735831e-05 -4.944854e-05 -5.121795e-05
## ASV2189      3.410635e-38  2.105452e-04  2.204425e-04  2.305358e-04
## ASV2257      2.584074e-38  1.553533e-04  1.627000e-04  1.699519e-04
## ASV2283      3.040027e-38  1.725733e-04  1.805420e-04  1.880912e-04
## ASV2328      3.040027e-38  1.725732e-04  1.805287e-04  1.880780e-04
## ASV2434     -4.282884e-38 -2.544423e-04 -2.663459e-04 -2.780694e-04
## ASV2648      3.040027e-38  1.725730e-04  1.805005e-04  1.880493e-04
## ASV2698      3.969934e-38  2.469916e-04  2.586317e-04  2.705735e-04
## ASV2775      5.017817e-38  2.962196e-04  3.098203e-04  3.233336e-04
## ASV3171      3.040027e-38  1.725728e-04  1.804737e-04  1.880219e-04
## ASV3227      3.740920e-38  2.188728e-04  2.288626e-04  2.387423e-04
## ASV3397      1.862479e-39  1.301832e-05  1.374450e-05  1.442585e-05
## ASV3444      4.180246e-38  2.463463e-04  2.577821e-04  2.690312e-04
## ASV3556      3.040027e-38  1.725725e-04  1.804402e-04  1.879878e-04
## ASV3606     -3.040027e-38 -1.725724e-04 -1.804271e-04 -1.879745e-04
## ASV4190      3.521442e-38  2.170331e-04  2.272747e-04  2.376664e-04
## ASV4197      4.290482e-38  2.516150e-04  2.632849e-04  2.746964e-04
## ASV4722      3.727856e-38  2.263866e-04  2.369751e-04  2.476386e-04
## ASV4765      8.670616e-39  5.698417e-05  5.964630e-05  6.252401e-05
## ASV4809      3.040027e-38  1.725721e-04  1.803952e-04  1.879420e-04
## ASV4846      2.572609e-38  1.608783e-04  1.684186e-04  1.762153e-04
## ASV4903     -9.356722e-39 -4.539714e-05 -4.732798e-05 -4.891844e-05
## ASV4944     -3.040027e-38 -1.725718e-04 -1.803816e-04 -1.879289e-04
## ASV5151     -8.791479e-39 -6.353048e-05 -6.676382e-05 -7.025405e-05
## ASV5413     -3.040027e-38 -1.725717e-04 -1.803715e-04 -1.879190e-04
## ASV5537     -3.040027e-38 -1.725715e-04 -1.803584e-04 -1.879058e-04
## ASV5688      3.040027e-38  1.725714e-04  1.803454e-04  1.878926e-04
## ASV5752      1.243878e-38  8.047345e-05  8.444768e-05  8.846563e-05
## ASV6122     -3.040027e-38 -1.725712e-04 -1.803356e-04 -1.878826e-04
## ASV6135      3.040027e-38  1.725711e-04  1.803226e-04  1.878694e-04
## ASV6188     -3.040027e-38 -1.725709e-04 -1.803096e-04 -1.878562e-04
## ASV6216      4.291012e-38  2.537348e-04  2.653846e-04  2.770036e-04
## ASV6242      3.040027e-38  1.725707e-04  1.802827e-04  1.878284e-04
## ASV6383      3.040027e-38  1.725705e-04  1.802698e-04  1.878152e-04
## ASV6781      3.040027e-38  1.725704e-04  1.802570e-04  1.878019e-04
## ASV6799     -3.040027e-38 -1.725702e-04 -1.802441e-04 -1.877887e-04
## ASV7374     -3.040027e-38 -1.725701e-04 -1.802313e-04 -1.877755e-04
## ASV7539     -3.040027e-38 -1.725699e-04 -1.802185e-04 -1.877623e-04
## ASV8591     -3.040027e-38 -1.725698e-04 -1.802057e-04 -1.877491e-04
## ASV8637      3.040027e-38  1.725696e-04  1.801930e-04  1.877359e-04
## ASV12796    -3.040027e-38 -1.725695e-04 -1.801802e-04 -1.877227e-04
## ASV1934      3.168520e-38  1.970552e-04  2.063213e-04  2.158377e-04
## ASV22549    -2.606906e-40  9.670218e-06  1.051748e-05  1.152407e-05
## ASV29857    -3.040027e-38 -1.725693e-04 -1.801678e-04 -1.877099e-04
## ASV3215      3.810256e-38  2.392691e-04  2.506358e-04  2.623158e-04
## ASV3236     -3.040027e-38 -1.725691e-04 -1.801543e-04 -1.876959e-04
## ASV3954     -3.040027e-38 -1.725690e-04 -1.801416e-04 -1.876827e-04
## ASV4850      3.040027e-38  1.725688e-04  1.801289e-04  1.876694e-04
## ASV5225      3.040027e-38  1.725687e-04  1.801163e-04  1.876562e-04
## ASV5532     -3.040027e-38 -1.725685e-04 -1.801037e-04 -1.876430e-04
## ASV7258      7.356746e-40  1.915640e-05  2.058205e-05  2.222498e-05
## ASV9474     -1.829704e-38 -9.919263e-05 -1.032942e-04 -1.073851e-04
## ASV11857    -3.040027e-38 -1.725682e-04 -1.800863e-04 -1.876251e-04
## ASV1202     -3.040027e-38 -1.725680e-04 -1.800738e-04 -1.876119e-04
## ASV14742     1.797837e-38  1.200694e-04  1.260241e-04  1.322317e-04
## ASV16652     9.184402e-39  6.096820e-05  6.408570e-05  6.719856e-05
## ASV2019      4.207641e-38  2.509927e-04  2.624399e-04  2.740367e-04
## ASV2410     -3.812021e-38 -2.327353e-04 -2.435655e-04 -2.545982e-04
## ASV2718      3.875721e-38  2.468730e-04  2.586857e-04  2.708855e-04
## ASV2738      4.796396e-38  2.820255e-04  2.947610e-04  3.075642e-04
## ASV2876      3.040027e-38  1.725677e-04  1.800462e-04  1.875830e-04
## ASV3177      3.040027e-38  1.725675e-04  1.800337e-04  1.875698e-04
## ASV4367      3.040027e-38  1.725674e-04  1.800212e-04  1.875566e-04
## ASV4635      7.220246e-39  5.694731e-05  6.011270e-05  6.343929e-05
## ASV4896     -4.249857e-40  1.265703e-05  1.383572e-05  1.520452e-05
## ASV4907      1.825889e-38  1.236633e-04  1.299764e-04  1.364454e-04
## ASV5230     -3.040027e-38 -1.725670e-04 -1.800199e-04 -1.875557e-04
## ASV6509     -3.040027e-38 -1.725669e-04 -1.800075e-04 -1.875425e-04
## ASV7376     -3.040027e-38 -1.725668e-04 -1.799950e-04 -1.875293e-04
## ASV8163     -3.040027e-38 -1.725666e-04 -1.799826e-04 -1.875161e-04
## ASV8195     -3.040027e-38 -1.725665e-04 -1.799702e-04 -1.875029e-04
## ASV8923      1.564948e-38  1.032958e-04  1.084568e-04  1.137290e-04
## ASV9666     -2.728745e-38 -1.533035e-04 -1.597881e-04 -1.663947e-04
## ASV1482      2.477237e-38  1.536848e-04  1.610560e-04  1.684482e-04
## ASV2726      3.190156e-38  2.024051e-04  2.121706e-04  2.221352e-04
## ASV3281     -3.040027e-38 -1.725661e-04 -1.799566e-04 -1.874884e-04
## ASV4235     -3.040027e-38 -1.725660e-04 -1.799443e-04 -1.874752e-04
## ASV4808      4.286934e-38  2.531235e-04  2.645285e-04  2.760868e-04
## ASV4861     -4.283689e-38 -2.545215e-04 -2.659620e-04 -2.776749e-04
## ASV5276      4.241240e-38  2.498318e-04  2.610595e-04  2.724293e-04
## ASV5837      3.436592e-38  2.151666e-04  2.253102e-04  2.357860e-04
## ASV7098      3.525946e-38  2.201664e-04  2.304961e-04  2.411844e-04
## ASV8451     -3.040027e-38 -1.725656e-04 -1.798881e-04 -1.874152e-04
## ASV8694     -3.040027e-38 -1.725655e-04 -1.798759e-04 -1.874020e-04
## ASV0905     -1.429364e-38 -9.053140e-05 -9.490064e-05 -9.932495e-05
## ASV2900      3.647573e-38  2.112101e-04  2.203553e-04  2.297881e-04
## ASV3963     -2.964512e-38 -1.678785e-04 -1.749435e-04 -1.822418e-04
## ASV0041     -2.938907e-38 -1.842951e-04 -1.932438e-04 -2.022165e-04
## ASV1865      2.859714e-38  1.874174e-04  1.967012e-04  2.062216e-04
## ASV1140      2.402015e-38  1.505695e-04  1.579443e-04  1.652547e-04
## ASV1179      3.553674e-38  2.225193e-04  2.330878e-04  2.439089e-04
## ASV0279      5.181018e-38  3.145806e-04  3.291163e-04  3.439316e-04
## ASV0043     -3.287927e-39 -2.794899e-05 -2.957691e-05 -3.132549e-05
## ASV2097     -2.989356e-38 -1.770582e-04 -1.849002e-04 -1.930201e-04
## ASV0309     -1.502889e-38 -8.795473e-05 -9.198217e-05 -9.596191e-05
## ASV0607      6.090462e-38  3.829983e-04  4.010643e-04  4.197686e-04
## ASV0025     -6.402158e-38 -4.010868e-04 -4.202133e-04 -4.397201e-04
## ASV2284     -1.239649e-38 -6.460212e-05 -6.744462e-05 -6.995858e-05
## ASV0556      9.864971e-39  6.777759e-05  7.110656e-05  7.469399e-05
## ASV5040      2.597255e-38  1.452080e-04  1.512023e-04  1.574132e-04
## ASV2924     -2.753971e-38 -1.550895e-04 -1.615515e-04 -1.682461e-04
## ASV1331      7.975941e-38  4.873848e-04  5.101771e-04  5.332791e-04
## ASV0506     -3.805681e-38 -2.230897e-04 -2.333538e-04 -2.434482e-04
## ASV1514      5.945817e-38  3.675436e-04  3.847974e-04  4.024206e-04
## ASV2144      5.053533e-38  3.054739e-04  3.197218e-04  3.340268e-04
## ASV2265      6.654328e-38  4.081387e-04  4.272914e-04  4.467073e-04
## ASV5156      1.612468e-38  8.860742e-05  9.255359e-05  9.626218e-05
## ASV5534      1.360131e-38  7.188260e-05  7.499353e-05  7.784243e-05
## ASV5747      1.579865e-53 -1.310712e-05 -1.398069e-05 -1.524880e-05
## ASV6657      3.123704e-38  1.836591e-04  1.921654e-04  2.005127e-04
## ASV0658     -3.561795e-38 -2.093071e-04 -2.188964e-04 -2.283969e-04
## ASV0716      8.915064e-39  5.084476e-05  5.311124e-05  5.533140e-05
## ASV1657      1.640683e-38  8.979463e-05  9.373151e-05  9.746815e-05
## ASV1885      1.244497e-39 -4.139239e-06 -4.594229e-06 -5.369904e-06
## ASV2333      7.434581e-38  4.505179e-04  4.714159e-04  4.925752e-04
## ASV3375      2.871737e-38  1.666158e-04  1.741915e-04  1.816506e-04
## ASV4317      2.845844e-38  1.757865e-04  1.840902e-04  1.925377e-04
## ASV9599      1.711521e-53 -1.310715e-05 -1.402936e-05 -1.529819e-05
## ASV0175     -9.990573e-38 -6.033999e-04 -6.312224e-04 -6.594206e-04
## ASV1032      3.091395e-38  1.796002e-04  1.877159e-04  1.957602e-04
## ASV1235      2.238318e-39  4.954083e-06  4.920541e-06  4.718369e-06
## ASV1262      8.755772e-38  5.319365e-04  5.565925e-04  5.816254e-04
## ASV1320      1.948659e-38  1.306268e-04  1.370525e-04  1.438338e-04
## ASV13797     3.306856e-38  1.978041e-04  2.069209e-04  2.160920e-04
## ASV1491      1.460350e-38  9.973086e-05  1.047230e-04  1.099646e-04
## ASV15014     1.711521e-53 -1.310718e-05 -1.404972e-05 -1.531829e-05
## ASV1510      2.481019e-38  1.621122e-04  1.699291e-04  1.781257e-04
## ASV1551     -1.104080e-38 -6.529902e-05 -6.828828e-05 -7.126945e-05
## ASV1919     -3.858843e-39 -1.031412e-05 -1.048917e-05 -1.032337e-05
## ASV2114      1.713869e-38  9.749063e-05  1.018692e-04  1.061456e-04
## ASV21486     1.711521e-53 -1.310720e-05 -1.404449e-05 -1.531095e-05
## ASV2448      4.569306e-38  2.708204e-04  2.832638e-04  2.956731e-04
## ASV2589      2.237777e-38  1.297648e-04  1.356627e-04  1.414718e-04
## ASV2608      3.614853e-38  2.179384e-04  2.280304e-04  2.382199e-04
## ASV2786      2.875533e-38  1.764020e-04  1.845980e-04  1.930162e-04
## ASV2827      3.773243e-38  2.258882e-04  2.363895e-04  2.468584e-04
## ASV2872      3.188979e-38  1.847219e-04  1.930797e-04  2.013194e-04
## ASV3125      3.747887e-38  2.205167e-04  2.305303e-04  2.405584e-04
## ASV3247      4.057156e-38  2.388180e-04  2.496898e-04  2.605462e-04
## ASV3451      1.711521e-53 -1.310728e-05 -1.411386e-05 -1.538314e-05
## ASV3465     -2.469012e-39 -2.896563e-05 -3.065593e-05 -3.271829e-05
## ASV3809      2.403302e-38  1.394288e-04  1.456320e-04  1.518652e-04
## ASV4006      5.058067e-38  2.963538e-04  3.097826e-04  3.231694e-04
## ASV4046      3.617860e-38  2.128680e-04  2.224716e-04  2.321472e-04
## ASV4938     -2.155665e-40 -1.446025e-05 -1.555416e-05 -1.688957e-05
## ASV5435      1.711521e-53 -1.310736e-05 -1.413582e-05 -1.540482e-05
## ASV5605      1.609979e-38  8.615720e-05  8.986042e-05  9.333540e-05
## ASV5635      1.711521e-53 -1.310739e-05 -1.413939e-05 -1.540779e-05
## ASV5743      4.497092e-38  2.681084e-04  2.804050e-04  2.927829e-04
## ASV6627      1.711521e-53 -1.310742e-05 -1.415149e-05 -1.542016e-05
## ASV6785      1.711521e-53 -1.310743e-05 -1.414972e-05 -1.541792e-05
## ASV7368      4.761317e-38  2.943813e-04  3.081117e-04  3.222544e-04
## ASV9118      1.508129e-38  8.128489e-05  8.476024e-05  8.807566e-05
## ASV9135      1.247077e-38  6.390574e-05  6.651118e-05  6.893045e-05
## ASV9435      2.510395e-38  1.406470e-04  1.467916e-04  1.528111e-04
## ASV9671      1.579865e-53 -1.310751e-05 -1.417183e-05 -1.544031e-05
## ASV0387     -5.040080e-38 -2.975041e-04 -3.110156e-04 -3.245793e-04
## ASV0454     -4.962213e-38 -2.956426e-04 -3.091705e-04 -3.227885e-04
## ASV0751     -3.309851e-38 -1.942836e-04 -2.030193e-04 -2.118193e-04
## ASV1081      1.277394e-38  7.827772e-05  8.199831e-05  8.571127e-05
## ASV1332      2.670614e-38  1.614832e-04  1.689449e-04  1.765023e-04
## ASV2659      4.138730e-38  2.563839e-04  2.684167e-04  2.807160e-04
## ASV2979      4.574727e-38  2.680315e-04  2.800825e-04  2.921911e-04
## ASV4184      2.022738e-38  1.094868e-04  1.140920e-04  1.185696e-04
## ASV6198      1.634206e-38  9.451583e-05  9.873643e-05  1.029584e-04
## ASV7454      2.972525e-38  1.750037e-04  1.828959e-04  1.908489e-04
## ASV8198      1.381746e-38  7.149124e-05  7.432603e-05  7.706595e-05
## ASV0855      6.318760e-38  3.897883e-04  4.079820e-04  4.266415e-04
## ASV10092     2.818463e-38  1.657178e-04  1.731768e-04  1.807122e-04
## ASV1532      3.358332e-38  2.117511e-04  2.218808e-04  2.322576e-04
## ASV2553      8.400286e-38  5.137326e-04  5.376842e-04  5.620489e-04
## ASV2741      3.236422e-38  2.055424e-04  2.154672e-04  2.255918e-04
## ASV4095      1.650114e-38  1.107093e-04  1.163213e-04  1.220521e-04
## ASV5295      2.695222e-38  1.530409e-04  1.596999e-04  1.663644e-04
## ASV5787      1.711521e-53 -1.310768e-05 -1.422215e-05 -1.549236e-05
## ASV9455      3.404879e-38  2.012791e-04  2.103333e-04  2.195355e-04
## ASV10879     3.459155e-38  2.093761e-04  2.189884e-04  2.288242e-04
## ASV3997      2.228766e-38  1.448488e-04  1.518686e-04  1.591544e-04
## ASV6760      9.272111e-39  4.296227e-05  4.442269e-05  4.577634e-05
## ASV6990      2.610804e-38  1.522032e-04  1.589534e-04  1.658058e-04
## ASV9560      1.690264e-38  9.469838e-05  9.875317e-05  1.028203e-04
## ASV0220      1.372524e-38  8.277801e-05  8.674619e-05  9.060814e-05
## ASV2518      3.270863e-38  2.014420e-04  2.109046e-04  2.205352e-04
## ASV3615      5.255024e-38  3.179047e-04  3.325277e-04  3.474303e-04
## ASV0075      1.248383e-38  6.953282e-05  7.265708e-05  7.560168e-05
## ASV8070      8.545617e-39  3.991178e-05  4.125582e-05  4.253385e-05
## ASV1658      2.564588e-38  1.509866e-04  1.578059e-04  1.646790e-04
## ASV0773      4.147203e-38  2.438287e-04  2.549555e-04  2.660261e-04
## ASV0799      1.308621e-39  7.829133e-06  8.168069e-06  8.529415e-06
## ASV1839     -9.031958e-39 -4.862145e-05 -5.075421e-05 -5.270749e-05
## ASV0265      3.621898e-38  2.323905e-04  2.437675e-04  2.553494e-04
## ASV3741      1.552936e-38  9.442072e-05  9.874234e-05  1.031866e-04
## ASV0847      5.380913e-38  3.279087e-04  3.432323e-04  3.587160e-04
## ASV1026      5.791672e-38  3.505819e-04  3.668180e-04  3.832451e-04
## ASV1222     -2.006763e-38 -1.122955e-04 -1.169537e-04 -1.217549e-04
## ASV0729      7.995788e-39  4.789632e-05  5.015811e-05  5.237726e-05
## ASV0143     -4.554584e-38 -2.674544e-04 -2.795297e-04 -2.916425e-04
## ASV1328      1.197601e-38  6.842314e-05  7.183630e-05  7.485240e-05
## ASV9078     -8.638951e-39 -6.724196e-05 -7.097660e-05 -7.488422e-05
## ASV0027     -6.129045e-38 -3.822378e-04 -4.004185e-04 -4.189163e-04
## ASV0546     -2.867009e-38 -1.683360e-04 -1.758638e-04 -1.834892e-04
## ASV1136      7.053137e-38  4.274327e-04  4.471782e-04  4.672605e-04
## ASV3081      3.320036e-38  2.037776e-04  2.132480e-04  2.229718e-04
## ASV0531      1.394782e-38  8.983440e-05  9.428129e-05  9.876279e-05
## ASV2525      1.990986e-38  1.174237e-04  1.226898e-04  1.280404e-04
## ASV1083     -8.493520e-39 -4.519635e-05 -4.694064e-05 -4.875326e-05
## ASV0424      1.227119e-38  7.597790e-05  7.952276e-05  8.317674e-05
## ASV0644     -1.733463e-53  8.944656e-06  9.813264e-06  1.067708e-05
## ASV6007      1.492095e-53 -1.316383e-05 -1.433828e-05 -1.561887e-05
## ASV0564      1.585796e-38  1.042190e-04  1.094131e-04  1.147161e-04
## ASV1938      2.007382e-38  1.145547e-04  1.194600e-04  1.244830e-04
## ASV6516     -4.277777e-38 -2.605948e-04 -2.727075e-04 -2.850054e-04
## ASV0503     -5.241223e-38 -3.071616e-04 -3.208252e-04 -3.346931e-04
## ASV6913     -5.220210e-38 -3.050436e-04 -3.188128e-04 -3.325655e-04
## ASV0164     -3.805648e-38 -2.412070e-04 -2.526404e-04 -2.645213e-04
## ASV1576      4.761563e-38  2.896899e-04  3.030789e-04  3.167547e-04
## ASV1725      2.125365e-38  1.391690e-04  1.461473e-04  1.532099e-04
## ASV4501      2.183865e-38  1.238216e-04  1.290805e-04  1.344576e-04
## ASV10678    -4.213446e-38 -2.544687e-04 -2.662559e-04 -2.781491e-04
## ASV0944      3.325204e-38  2.108598e-04  2.208963e-04  2.312814e-04
## ASV2292      5.476757e-38  3.304445e-04  3.456151e-04  3.610502e-04
## ASV1090      3.521312e-38  2.161516e-04  2.261170e-04  2.364122e-04
## ASV9117     -1.897843e-38 -1.065290e-04 -1.109518e-04 -1.155261e-04
## ASV0285     -1.878554e-38 -1.260999e-04 -1.325612e-04 -1.391144e-04
## ASV0463     -3.568047e-38 -2.117619e-04 -2.212069e-04 -2.309027e-04
## ASV3199      3.134678e-38  1.829364e-04  1.909989e-04  1.992294e-04
## ASV0150     -1.103024e-38 -7.374472e-05 -7.743546e-05 -8.124885e-05
## ASV6583     -1.892061e-38 -1.089354e-04 -1.135044e-04 -1.183361e-04
## ASV0392      2.792587e-38  1.727913e-04  1.807996e-04  1.890945e-04
## ASV14007    -3.459648e-38 -2.094126e-04 -2.190062e-04 -2.288122e-04
## ASV0177     -1.987566e-38 -1.160522e-04 -1.211068e-04 -1.263264e-04
## ASV6448     -1.213724e-38 -8.793902e-05 -9.268934e-05 -9.754719e-05
## ASV5399     -3.657760e-39 -3.557555e-05 -3.782245e-05 -4.017126e-05
## ASV0277     -6.815782e-39 -4.295861e-05 -4.500913e-05 -4.711188e-05
## ASV2599      1.458945e-38  7.306914e-05  7.601113e-05  7.867132e-05
## ASV13465    -1.217653e-38 -5.884158e-05 -6.109988e-05 -6.310488e-05
## ASV2412      1.749340e-38  1.081579e-04  1.132039e-04  1.183881e-04
## ASV0423      3.278161e-38  2.125327e-04  2.228266e-04  2.335446e-04
## ASV5187      2.373825e-38  1.335361e-04  1.391252e-04  1.448774e-04
## ASV0701     -8.100065e-38 -4.975814e-04 -5.210554e-04 -5.447622e-04
## ASV4248      1.808802e-38  1.181978e-04  1.241834e-04  1.301695e-04
## ASV0519      3.303489e-38  2.087612e-04  2.187688e-04  2.290025e-04
## ASV0764      4.817093e-39  3.545405e-05  3.731153e-05  3.929720e-05
## ASV5385     -4.230483e-38 -2.616983e-04 -2.740295e-04 -2.865898e-04
## ASV3021     -2.693519e-38 -1.488176e-04 -1.552319e-04 -1.614949e-04
## ASV4119     -1.533501e-38 -8.315562e-05 -8.659678e-05 -9.001134e-05
## ASV2534      7.307864e-39  4.298602e-05  4.476134e-05  4.671637e-05
## ASV1061      2.986485e-38  2.000454e-04  2.099752e-04  2.203747e-04
## ASV0670      4.508419e-38  2.789715e-04  2.921377e-04  3.055315e-04
## ASV1384      1.797613e-38  1.204297e-04  1.264811e-04  1.327217e-04
## ASV1981      4.151370e-38  2.596336e-04  2.720296e-04  2.846304e-04
## ASV9632     -1.643466e-38 -8.702391e-05 -9.039257e-05 -9.384559e-05
## ASV4564      1.012326e-38  6.395345e-05  6.702284e-05  7.016001e-05
## ASV5289     -9.454109e-39 -5.792748e-05 -6.071311e-05 -6.346663e-05
## ASV0516      8.568451e-38  5.289000e-04  5.537500e-04  5.790678e-04
## ASV1463     -3.200516e-38 -1.909489e-04 -1.997050e-04 -2.085029e-04
## ASV0969      1.511912e-38  8.888331e-05  9.288258e-05  9.690285e-05
## ASV1113     -3.998190e-38 -2.464676e-04 -2.579778e-04 -2.697664e-04
## ASV1234      4.394788e-40 -8.248313e-06 -9.121631e-06 -1.009317e-05
## ASV3814      8.595295e-39  3.828842e-05  3.932805e-05  4.042528e-05
## ASV1000      4.186067e-38  2.521918e-04  2.638128e-04  2.755640e-04
## ASV0079     -2.429104e-39 -2.196674e-05 -2.324387e-05 -2.465783e-05
## ASV0145      1.504519e-38  8.596624e-05  8.964981e-05  9.342236e-05
## ASV0457     -5.317495e-38 -3.176915e-04 -3.322841e-04 -3.469586e-04
## ASV1485      1.628540e-38  1.032176e-04  1.081614e-04  1.132510e-04
## ASV0535     -1.188618e-38 -7.024470e-05 -7.324725e-05 -7.646266e-05
## ASV0259     -3.416494e-38 -2.077307e-04 -2.174331e-04 -2.272085e-04
## ASV0570      1.362727e-39  1.500469e-05  1.593981e-05  1.699075e-05
## ASV0906      4.485730e-38  2.703818e-04  2.827877e-04  2.953964e-04
## ASV1748     -2.368600e-38 -1.585193e-04 -1.664518e-04 -1.746533e-04
## ASV5520     -1.289010e-38 -9.342880e-05 -9.836258e-05 -1.035271e-04
## ASV2288     -5.252116e-38 -3.100395e-04 -3.243658e-04 -3.384920e-04
## ASV1887     -7.553707e-39 -5.789006e-05 -6.114277e-05 -6.446759e-05
## ASV0374     -1.691508e-38 -9.861602e-05 -1.029832e-04 -1.074102e-04
## ASV0823      5.133624e-38  3.056316e-04  3.194256e-04  3.334919e-04
## ASV0717      2.460724e-38  1.532375e-04  1.604718e-04  1.678784e-04
## ASV0431      1.787548e-38  1.059518e-04  1.108300e-04  1.156763e-04
## ASV1030      6.998089e-38  4.429723e-04  4.641764e-04  4.859491e-04
## ASV1082     -1.049765e-38 -6.481477e-05 -6.787919e-05 -7.098440e-05
## ASV2684      4.864533e-39  4.034361e-05  4.269862e-05  4.513582e-05
## ASV0051      6.303534e-38  3.940649e-04  4.126428e-04  4.317829e-04
## ASV0513      2.399094e-39  1.640242e-05  1.732493e-05  1.819872e-05
## ASV0581      8.083178e-38  5.000207e-04  5.236258e-04  5.476298e-04
## ASV7282      1.252159e-38  8.709804e-05  9.148923e-05  9.617276e-05
## ASV3009     -4.453000e-38 -2.742458e-04 -2.871137e-04 -3.002152e-04
## ASV2106     -2.406350e-38 -1.398568e-04 -1.460287e-04 -1.522925e-04
## ASV1012      1.317516e-38  8.750649e-05  9.187733e-05  9.637869e-05
## ASV0921     -1.329964e-39 -6.037004e-06 -6.208335e-06 -6.383627e-06
## ASV0010     -6.226606e-38 -3.907565e-04 -4.093177e-04 -4.283532e-04
## ASV1178      7.543074e-40  7.830310e-06  8.384244e-06  8.911648e-06
## ASV2848     -3.520821e-38 -2.107973e-04 -2.203596e-04 -2.301359e-04
## ASV0586      9.140052e-38  5.671037e-04  5.938730e-04  6.211864e-04
## ASV4225      1.525470e-39  1.592771e-05  1.741642e-05  1.849365e-05
## ASV2156     -3.821022e-38 -2.363908e-04 -2.475686e-04 -2.589250e-04
## ASV9778     -2.456204e-38 -1.492589e-04 -1.561822e-04 -1.632028e-04
## ASV0493     -5.482259e-38 -3.307638e-04 -3.458835e-04 -3.613355e-04
## ASV3770      1.078128e-38  6.123855e-05  6.361122e-05  6.628224e-05
## ASV0470      6.543959e-38  4.029777e-04  4.217837e-04  4.410323e-04
## ASV0262     -2.508091e-38 -1.669824e-04 -1.753633e-04 -1.839821e-04
## ASV0998      3.970297e-38  2.469361e-04  2.585783e-04  2.705038e-04
## ASV7708     -1.132383e-38 -6.771595e-05 -7.070989e-05 -7.383282e-05
## ASV0453     -1.537160e-39 -8.597337e-06 -8.917851e-06 -9.295299e-06
## ASV0044      8.214650e-38  5.077369e-04  5.313921e-04  5.557378e-04
## ASV5490      1.344841e-38  7.981807e-05  8.346625e-05  8.711585e-05
## ASV2638      2.997621e-39  2.140662e-05  2.263759e-05  2.379406e-05
## ASV0829     -8.594898e-39 -4.591937e-05 -4.775810e-05 -4.960997e-05
## ASV0601      1.439565e-38  9.319621e-05  9.767368e-05  1.023637e-04
## ASV0234      3.600485e-38  2.204087e-04  2.307790e-04  2.412414e-04
## ASV0133      4.698288e-38  2.912832e-04  3.049256e-04  3.189431e-04
## ASV0323      4.881431e-38  3.084750e-04  3.231806e-04  3.383393e-04
## ASV0854     -4.381738e-39 -2.368470e-05 -2.470363e-05 -2.566212e-05
## ASV0110      6.238672e-38  3.906244e-04  4.090704e-04  4.280694e-04
## ASV0816      3.647516e-39  2.131369e-05  2.224160e-05  2.320239e-05
## ASV1031     -1.048331e-38 -6.162478e-05 -6.426807e-05 -6.707537e-05
## ASV0144     -2.607409e-38 -1.594319e-04 -1.668913e-04 -1.744508e-04
## ASV0020     -1.028366e-38 -7.229652e-05 -7.599925e-05 -7.993702e-05
## ASV0962     -2.122252e-38 -1.304761e-04 -1.365708e-04 -1.427899e-04
## ASV0794      3.963597e-38  2.565265e-04  2.690079e-04  2.818910e-04
## ASV7117     -2.141849e-38 -1.330556e-04 -1.391574e-04 -1.455696e-04
## ASV1008     -1.467436e-38 -9.458305e-05 -9.914547e-05 -1.038852e-04
## ASV0096      6.715224e-38  4.207864e-04  4.406090e-04  4.610885e-04
## ASV0128     -3.897035e-38 -2.513356e-04 -2.634956e-04 -2.761086e-04
## ASV5232      3.027018e-38  1.905172e-04  1.997426e-04  2.090524e-04
## ASV0031      2.765044e-39  1.238311e-05  1.285817e-05  1.320685e-05
## ASV1744     -4.501257e-39 -2.899387e-05 -3.030765e-05 -3.177946e-05
## ASV0289      3.767706e-38  2.343810e-04  2.453711e-04  2.567016e-04
## ASV7413     -6.380907e-39 -5.167536e-05 -5.465581e-05 -5.774071e-05
## ASV0822     -4.716991e-38 -2.831309e-04 -2.960276e-04 -3.091723e-04
## ASV8111     -4.169062e-38 -2.397472e-04 -2.505946e-04 -2.612070e-04
## ASV0687      2.759518e-38  1.756401e-04  1.841272e-04  1.928026e-04
## ASV0112      1.120695e-38  5.612154e-05  5.858686e-05  6.059212e-05
## ASV0987      2.225322e-38  1.415524e-04  1.483957e-04  1.553982e-04
## ASV5332     -1.411156e-38 -7.879867e-05 -8.192982e-05 -8.530049e-05
## ASV1129     -2.973524e-38 -1.854159e-04 -1.941085e-04 -2.030984e-04
## ASV1274     -9.717767e-39 -6.083293e-05 -6.366813e-05 -6.662352e-05
## ASV0119      5.478743e-38  3.428676e-04  3.589964e-04  3.756585e-04
## ASV0890      1.342358e-38  8.665964e-05  9.076379e-05  9.510379e-05
## ASV0848      7.928293e-38  4.918982e-04  5.150680e-04  5.387547e-04
## ASV5944     -4.378588e-38 -2.575337e-04 -2.694943e-04 -2.811856e-04
## ASV19741    -4.182093e-38 -2.578389e-04 -2.697671e-04 -2.820947e-04
## ASV0504     -4.911402e-38 -2.959993e-04 -3.094858e-04 -3.232954e-04
## ASV2146     -3.209636e-38 -1.942896e-04 -2.029916e-04 -2.121191e-04
## ASV0089     -2.517405e-38 -1.614460e-04 -1.690786e-04 -1.771139e-04
## ASV2301     -2.729800e-38 -1.710809e-04 -1.791937e-04 -1.875238e-04
## ASV2982      7.442762e-39  5.056217e-05  5.362165e-05  5.626445e-05
## ASV0891     -3.502569e-38 -2.167956e-04 -2.269017e-04 -2.373137e-04
## ASV0093      5.691894e-38  3.519390e-04  3.684341e-04  3.853249e-04
## ASV0042      2.755813e-38  1.667474e-04  1.745376e-04  1.823540e-04
## ASV0980      3.856416e-38  2.338034e-04  2.445295e-04  2.555019e-04
## ASV0069     -8.801954e-39 -5.872488e-05 -6.156334e-05 -6.460488e-05
## ASV1364     -6.623203e-39 -4.177961e-05 -4.363625e-05 -4.568022e-05
## ASV0524     -1.027609e-38 -6.777714e-05 -7.104838e-05 -7.452374e-05
## ASV0435      7.471152e-38  4.651475e-04  4.870957e-04  5.095828e-04
## ASV0517     -3.056280e-38 -1.889391e-04 -1.978598e-04 -2.069251e-04
## ASV3167     -1.268383e-38 -8.125344e-05 -8.527669e-05 -8.931771e-05
## ASV4280     -4.995943e-39 -3.421541e-05 -3.571563e-05 -3.752792e-05
## ASV1158      1.708228e-38  1.129040e-04  1.185896e-04  1.243595e-04
## ASV2214      1.425520e-38  8.824133e-05  9.223648e-05  9.649854e-05
## ASV0544     -1.668881e-38 -1.043649e-04 -1.093905e-04 -1.144643e-04
## ASV5326     -3.187033e-39 -1.899559e-05 -1.989385e-05 -2.076995e-05
## ASV3765     -4.494004e-38 -2.717373e-04 -2.844555e-04 -2.971753e-04
## ASV4646      6.121052e-40 -5.882625e-06 -6.528955e-06 -7.287419e-06
## ASV0090      5.184869e-39  2.753818e-05  2.870504e-05  2.979222e-05
## ASV3680      4.341329e-38  2.571004e-04  2.686152e-04  2.803629e-04
## ASV0111      7.565369e-39  4.281703e-05  4.470479e-05  4.655366e-05
## ASV0768      2.548455e-38  1.590531e-04  1.666524e-04  1.743689e-04
## ASV4862     -1.739272e-39 -9.497676e-06 -9.829045e-06 -1.021573e-05
## ASV1742     -3.551583e-38 -2.109998e-04 -2.204405e-04 -2.301326e-04
## ASV3701     -5.809251e-39 -3.709101e-05 -3.857695e-05 -4.041583e-05
## ASV2386     -2.065815e-38 -1.266135e-04 -1.326265e-04 -1.386416e-04
## ASV0375     -4.939936e-38 -2.967005e-04 -3.102367e-04 -3.240284e-04
## ASV2796      1.334889e-38  7.937735e-05  8.285278e-05  8.650780e-05
## ASV1369      3.408110e-38  2.050180e-04  2.143460e-04  2.239043e-04
## ASV10272    -3.040027e-38 -1.853784e-04 -1.940641e-04 -2.028212e-04
## ASV10354    -3.040027e-38 -1.853783e-04 -1.940495e-04 -2.028057e-04
## ASV1067     -2.322149e-39 -1.569491e-05 -1.648584e-05 -1.730845e-05
## ASV1900      6.222341e-38  3.878496e-04  4.061452e-04  4.249160e-04
## ASV4079     -1.036164e-38 -6.630667e-05 -6.955798e-05 -7.285158e-05
## ASV4149      4.409513e-38  2.617254e-04  2.735282e-04  2.855183e-04
## ASV5140     -3.040027e-38 -1.853784e-04 -1.940348e-04 -2.027902e-04
## ASV10782    -1.804520e-39 -8.662818e-06 -8.961098e-06 -9.241919e-06
## ASV4273     -7.479188e-39 -4.281040e-05 -4.472787e-05 -4.659850e-05
## ASV8121      2.868455e-38  1.786944e-04  1.870621e-04  1.957097e-04
## ASV8438     -3.040027e-38 -1.853784e-04 -1.940216e-04 -2.027764e-04
## ASV9390     -3.040027e-38 -1.853784e-04 -1.940070e-04 -2.027609e-04
## ASV1340      4.093787e-38  2.564319e-04  2.685811e-04  2.810551e-04
## ASV2650     -4.569051e-38 -2.756203e-04 -2.882832e-04 -3.011406e-04
## ASV4674      2.278712e-38  1.409291e-04  1.475009e-04  1.542603e-04
## ASV10492    -1.805289e-39 -1.211485e-05 -1.265983e-05 -1.328681e-05
## ASV11430    -3.040027e-38 -1.853783e-04 -1.939853e-04 -2.027379e-04
## ASV12135    -3.040027e-38 -1.853783e-04 -1.939708e-04 -2.027224e-04
## ASV14970    -3.040027e-38 -1.853783e-04 -1.939563e-04 -2.027069e-04
## ASV1954      3.415967e-38  2.112806e-04  2.211984e-04  2.313350e-04
## ASV2613      5.369877e-38  3.303344e-04  3.457179e-04  3.614749e-04
## ASV2757      2.209087e-38  1.309910e-04  1.369119e-04  1.429090e-04
## ASV2909     -3.113541e-38 -1.933122e-04 -2.024786e-04 -2.117968e-04
## ASV2954     -6.464487e-39 -3.740765e-05 -3.910658e-05 -4.076421e-05
## ASV2969      2.886375e-38  1.821552e-04  1.908583e-04  1.997947e-04
## ASV3410      5.666365e-39  3.896485e-05  4.088103e-05  4.295818e-05
## ASV3575      1.564300e-38  9.706354e-05  1.015692e-04  1.062495e-04
## ASV4275      3.536200e-38  2.109238e-04  2.205280e-04  2.302447e-04
## ASV4652      5.307887e-39  3.673501e-05  3.854750e-05  4.051137e-05
## ASV4761      3.526201e-38  2.106995e-04  2.203063e-04  2.300270e-04
## ASV6003      2.522470e-38  1.622834e-04  1.700900e-04  1.782131e-04
## ASV6110     -3.040027e-38 -1.853784e-04 -1.939872e-04 -2.027404e-04
## ASV7427      1.959506e-38  1.212076e-04  1.268232e-04  1.326394e-04
## ASV8092     -3.040027e-38 -1.853784e-04 -1.939778e-04 -2.027304e-04
## ASV8169     -3.040027e-38 -1.853783e-04 -1.939632e-04 -2.027149e-04
## ASV9693      1.301781e-38  8.097959e-05  8.477749e-05  8.868664e-05
## ASV10913     1.384640e-38  8.908529e-05  9.336456e-05  9.782074e-05
## ASV1979     -5.120549e-39 -3.032805e-05 -3.167850e-05 -3.306300e-05
## ASV3772      3.780361e-38  2.300183e-04  2.406049e-04  2.514483e-04
## ASV0113      7.657695e-39  4.353722e-05  4.552389e-05  4.741470e-05
## ASV1800     -2.968267e-39 -1.971279e-05 -2.061949e-05 -2.161922e-05
## ASV2335     -4.067643e-38 -2.341268e-04 -2.447369e-04 -2.551104e-04
## ASV0692      1.261345e-38  7.973656e-05  8.348993e-05  8.739958e-05
## ASV1120      1.632735e-38  1.006886e-04  1.054214e-04  1.102378e-04
## ASV1434     -8.658433e-38 -5.340603e-04 -5.591700e-04 -5.847326e-04
## ASV0076     -9.294980e-39 -6.173762e-05 -6.469961e-05 -6.788244e-05
## ASV0361      6.463148e-38  4.042469e-04  4.232798e-04  4.429121e-04
## ASV2231     -2.017176e-38 -1.352460e-04 -1.419476e-04 -1.489911e-04
## ASV2018     -8.523333e-40 -1.088400e-05 -1.141925e-05 -1.223543e-05
## ASV1529      5.329279e-38  3.352546e-04  3.512153e-04  3.676064e-04
## ASV0841     -3.123463e-39 -1.707194e-05 -1.777216e-05 -1.847247e-05
## ASV2556     -3.299648e-38 -2.019538e-04 -2.113311e-04 -2.209063e-04
## ASV2777      4.323659e-38  2.559220e-04  2.673948e-04  2.790802e-04
## ASV0355      3.338025e-38  2.094970e-04  2.193381e-04  2.295529e-04
## ASV5169     -4.675239e-38 -2.868418e-04 -3.002743e-04 -3.139183e-04
## ASV3091      2.191844e-38  1.403325e-04  1.470333e-04  1.540195e-04
## ASV2435      3.323790e-38  2.025344e-04  2.120003e-04  2.215573e-04
## ASV6822     -2.143986e-38 -1.308626e-04 -1.368838e-04 -1.430648e-04
## ASV12605    -5.095941e-38 -3.131735e-04 -3.278025e-04 -3.427225e-04
## ASV0286     -3.410740e-38 -2.095438e-04 -2.192488e-04 -2.292473e-04
## ASV0074     -4.693796e-40 -1.225887e-05 -1.304667e-05 -1.412293e-05
## ASV2485     -2.061041e-39 -8.558711e-06 -9.067719e-06 -9.282316e-06
## ASV1233     -6.447314e-38 -4.001118e-04 -4.189016e-04 -4.381870e-04
## ASV0356     -3.150438e-38 -1.914448e-04 -2.002177e-04 -2.092372e-04
## ASV2918     -3.966520e-38 -2.318929e-04 -2.426145e-04 -2.530675e-04
## ASV1427      3.429366e-40 -1.453952e-07 -2.040126e-07 -3.313699e-07
## ASV1409      3.677986e-38  2.341008e-04  2.452343e-04  2.568207e-04
## ASV0770      1.280859e-38  7.232359e-05  7.556794e-05  7.866848e-05
## ASV1403     -4.569919e-38 -2.811551e-04 -2.942369e-04 -3.076506e-04
## ASV0314     -2.459058e-38 -1.525190e-04 -1.596627e-04 -1.669987e-04
## ASV0187      1.384455e-39  3.483776e-06  3.439930e-06  3.349875e-06
## ASV0313     -3.380405e-38 -2.041821e-04 -2.136679e-04 -2.232177e-04
## ASV1087      5.713278e-38  3.559093e-04  3.725865e-04  3.897994e-04
## ASV1970      3.456843e-39  1.893373e-05  1.978844e-05  2.057038e-05
## ASV0754      4.598408e-38  2.863718e-04  2.998210e-04  3.136700e-04
## ASV3775     -3.094402e-38 -1.950671e-04 -2.043284e-04 -2.138856e-04
## ASV0132      1.337278e-38  8.005818e-05  8.379955e-05  8.750100e-05
## ASV2329     -7.242003e-39 -5.533575e-05 -5.828220e-05 -6.145910e-05
## ASV0561      4.041917e-38  2.448212e-04  2.561990e-04  2.676759e-04
## ASV0130     -4.822305e-38 -2.993822e-04 -3.135068e-04 -3.279280e-04
## ASV0226      5.486676e-38  3.397569e-04  3.556913e-04  3.720157e-04
## ASV12648    -3.957854e-38 -2.414511e-04 -2.524970e-04 -2.639267e-04
## ASV0204      5.471322e-38  3.387163e-04  3.545740e-04  3.708416e-04
## ASV0767      1.032003e-38  5.672477e-05  5.924659e-05  6.159409e-05
## ASV0335     -2.971859e-38 -1.854707e-04 -1.941800e-04 -2.031592e-04
## ASV5901     -9.805845e-39 -5.565138e-05 -5.807102e-05 -6.049402e-05
## ASV0596     -1.273018e-38 -7.176431e-05 -7.496688e-05 -7.805035e-05
## ASV9271      9.664956e-39  6.875895e-05  7.242608e-05  7.618091e-05
## ASV0904      4.785330e-38  2.983666e-04  3.125018e-04  3.269509e-04
## ASV15270    -1.158588e-38 -7.740359e-05 -8.142323e-05 -8.540665e-05
## ASV0990     -1.337005e-38 -8.619886e-05 -9.029033e-05 -9.460988e-05
## ASV0155     -2.928215e-38 -1.797391e-04 -1.881538e-04 -1.967084e-04
## ASV0086     -3.913130e-40 -8.698698e-07 -9.162412e-07 -8.794055e-07
## ASV2581     -2.542304e-39 -1.112718e-05 -1.161473e-05 -1.190495e-05
## ASV1579     -3.314543e-38 -2.118830e-04 -2.219974e-04 -2.325250e-04
## ASV7730      1.141014e-53 -8.154909e-06 -8.838235e-06 -9.622499e-06
## ASV0897      1.389932e-38  8.681430e-05  9.097490e-05  9.518828e-05
## ASV1975      6.621688e-38  4.084776e-04  4.276123e-04  4.471693e-04
## ASV0759     -1.859264e-39 -9.827593e-06 -1.028934e-05 -1.068082e-05
## ASV3082     -3.988679e-38 -2.478917e-04 -2.595229e-04 -2.714834e-04
## ASV3195     -6.872618e-38 -4.324226e-04 -4.528125e-04 -4.739547e-04
## ASV0427      3.594451e-38  2.268645e-04  2.376343e-04  2.487622e-04
## ASV2674      7.922651e-39  4.704968e-05  4.924716e-05  5.139118e-05
## ASV1500      1.145959e-38  7.074228e-05  7.375281e-05  7.713873e-05
## ASV0102     -4.090128e-38 -2.595440e-04 -2.718991e-04 -2.847036e-04
## ASV1217     -1.111911e-38 -6.551469e-05 -6.863743e-05 -7.161538e-05
## ASV4998     -4.406020e-39 -2.726888e-05 -2.855598e-05 -2.986400e-05
## ASV2890      6.081302e-38  3.709956e-04  3.881982e-04  4.057367e-04
## ASV0672     -2.582478e-38 -1.610085e-04 -1.685837e-04 -1.763805e-04
## ASV6960     -2.210618e-38 -1.451870e-04 -1.524451e-04 -1.598258e-04
## ASV0821      3.996265e-38  2.407687e-04  2.521389e-04  2.633843e-04
## ASV1995     -3.687907e-38 -2.298565e-04 -2.406833e-04 -2.518063e-04
## ASV0211     -1.964535e-38 -1.291309e-04 -1.353524e-04 -1.419396e-04
## ASV0364      2.143964e-38  1.342848e-04  1.405344e-04  1.470656e-04
## ASV3616      4.872433e-38  2.884392e-04  3.017950e-04  3.149867e-04
## ASV1996      5.286083e-38  3.255493e-04  3.406247e-04  3.561859e-04
## ASV1881     -8.359372e-39 -5.277218e-05 -5.530003e-05 -5.789143e-05
## ASV1089      5.144287e-38  3.171041e-04  3.320706e-04  3.472371e-04
## ASV1450     -1.084267e-38 -6.514095e-05 -6.822333e-05 -7.125151e-05
## ASV4643     -2.945056e-38 -1.812655e-04 -1.896623e-04 -1.983074e-04
## ASV3458      1.397648e-38  8.869901e-05  9.345164e-05  9.781187e-05
## ASV2543     -1.230170e-38 -7.932820e-05 -8.312448e-05 -8.710170e-05
## ASV3306     -1.413873e-38 -8.964464e-05 -9.443131e-05 -9.883433e-05
## ASV0218     -2.834117e-38 -1.766800e-04 -1.849562e-04 -1.935124e-04
## ASV3727      1.812312e-38  1.180776e-04  1.237889e-04  1.297695e-04
## ASV4394     -1.988477e-38 -1.275681e-04 -1.336507e-04 -1.400068e-04
## ASV2636     -6.278898e-41  9.435448e-06  1.016854e-05  1.114030e-05
## ASV5116      5.329684e-39  3.207555e-05  3.345365e-05  3.493960e-05
## ASV1394     -5.050616e-38 -3.144608e-04 -3.292468e-04 -3.444505e-04
## ASV0656     -5.034807e-38 -3.087319e-04 -3.230980e-04 -3.377737e-04
## ASV0475      7.493342e-38  4.686907e-04  4.907821e-04  5.135501e-04
## ASV1042      1.880650e-38  1.170809e-04  1.225615e-04  1.282147e-04
## ASV1199     -3.841110e-38 -2.418514e-04 -2.532173e-04 -2.650490e-04
## ASV12962    -2.846091e-39 -1.629290e-05 -1.698912e-05 -1.770156e-05
## ASV0853      3.545569e-38  2.192662e-04  2.296990e-04  2.402064e-04
## ASV5069     -5.753133e-39 -4.901481e-05 -5.189245e-05 -5.492076e-05
## ASV7825     -2.194296e-38 -1.367065e-04 -1.432635e-04 -1.498799e-04
## ASV0339      2.462269e-38  1.533382e-04  1.604879e-04  1.679017e-04
## ASV2965      2.135155e-38  1.334748e-04  1.397661e-04  1.462438e-04
## ASV2347     -2.934600e-38 -1.776150e-04 -1.858545e-04 -1.941794e-04
## ASV0541      1.162348e-38  7.754091e-05  8.122004e-05  8.522479e-05
## ASV0369      3.376901e-38  2.080349e-04  2.177112e-04  2.276479e-04
## ASV0171      1.690821e-38  1.051994e-04  1.101283e-04  1.152208e-04
## ASV2235      4.275898e-38  2.534551e-04  2.648541e-04  2.764562e-04
## ASV5809     -3.870990e-38 -2.372111e-04 -2.482279e-04 -2.594902e-04
## ASV1267      4.844768e-38  2.986127e-04  3.126118e-04  3.268836e-04
## ASV0207     -5.238866e-38 -3.216329e-04 -3.366657e-04 -3.519695e-04
## ASV3126     -6.051393e-38 -3.798356e-04 -3.977731e-04 -4.162918e-04
## ASV0183     -6.769651e-38 -4.191657e-04 -4.387559e-04 -4.588923e-04
## ASV1792      2.376564e-38  1.438487e-04  1.504710e-04  1.572035e-04
## ASV2001     -5.869279e-38 -3.693294e-04 -3.867222e-04 -4.047813e-04
## ASV5732     -5.870030e-38 -3.635224e-04 -3.805740e-04 -3.980390e-04
## ASV2857     -3.676217e-38 -2.301697e-04 -2.409710e-04 -2.521649e-04
## ASV1052     -2.755478e-38 -1.680169e-04 -1.758265e-04 -1.837809e-04
## ASV3226     -1.718414e-38 -1.069126e-04 -1.118537e-04 -1.170112e-04
## ASV3766     -6.278329e-39 -3.945034e-05 -4.132002e-05 -4.324801e-05
## ASV0982     -1.781361e-38 -1.151872e-04 -1.206768e-04 -1.264660e-04
## ASV0489      7.090036e-40 -2.052890e-06 -2.306663e-06 -2.739450e-06
## ASV3990     -6.309199e-38 -3.950771e-04 -4.136828e-04 -4.328984e-04
## ASV0433     -3.856348e-38 -2.350142e-04 -2.459192e-04 -2.570052e-04
## ASV0684     -1.561629e-38 -1.009865e-04 -1.057621e-04 -1.108444e-04
## ASV0063     -4.478383e-38 -2.777049e-04 -2.906906e-04 -3.040404e-04
## ASV1399      8.942694e-39  4.796969e-05  5.004615e-05  5.196131e-05
## ASV3093     -7.475139e-38 -4.705690e-04 -4.927970e-04 -5.158185e-04
## ASV1771      8.795778e-39  5.751478e-05  6.027644e-05  6.319696e-05
## ASV7910     -4.035016e-38 -2.383909e-04 -2.494335e-04 -2.603130e-04
## ASV3718     -5.067986e-38 -3.152380e-04 -3.301011e-04 -3.453263e-04
## ASV0039     -3.880856e-38 -2.477855e-04 -2.594758e-04 -2.717563e-04
## ASV6469     -8.338458e-38 -5.153860e-04 -5.396820e-04 -5.643990e-04
## ASV8186     -5.613175e-38 -3.489533e-04 -3.653773e-04 -3.822199e-04
## ASV1091     -5.390966e-39 -3.542876e-05 -3.710904e-05 -3.891667e-05
## ASV16930    -6.841221e-38 -4.265204e-04 -4.466409e-04 -4.672910e-04
## ASV7234     -5.131346e-38 -3.195124e-04 -3.344869e-04 -3.499293e-04
## ASV1560     -5.975621e-39 -3.830775e-05 -4.014276e-05 -4.205193e-05
## ASV2968      9.829224e-39  6.427221e-05  6.742167e-05  7.069260e-05
## ASV3824     -5.321479e-38 -3.286471e-04 -3.441036e-04 -3.598567e-04
## ASV0442     -3.260640e-38 -2.046845e-04 -2.143548e-04 -2.243371e-04
## ASV0677     -2.648929e-38 -1.567459e-04 -1.637420e-04 -1.708906e-04
## ASV4796     -3.589275e-38 -2.190138e-04 -2.291301e-04 -2.394978e-04
## ASV2206     -5.581201e-38 -3.486656e-04 -3.650319e-04 -3.819448e-04
## ASV2884      1.109874e-38  6.948577e-05  7.272135e-05  7.609651e-05
## ASV0482     -2.012834e-38 -1.265144e-04 -1.324383e-04 -1.386140e-04
## ASV1273      4.594520e-38  2.894120e-04  3.031242e-04  3.172705e-04
## ASV1910      6.965553e-39  3.891661e-05  4.054824e-05  4.219662e-05
## ASV0105      3.648005e-38  2.200631e-04  2.302765e-04  2.405491e-04
## ASV0149      3.739781e-38  2.326461e-04  2.435819e-04  2.548159e-04
## ASV5007     -5.791031e-38 -3.622472e-04 -3.793030e-04 -3.968999e-04
## ASV0757      4.985611e-38  3.127393e-04  3.274737e-04  3.427146e-04
## ASV11952    -4.245817e-38 -2.599075e-04 -2.720462e-04 -2.843750e-04
## ASV4102      3.296684e-38  2.064257e-04  2.162008e-04  2.262385e-04
## ASV1034      4.236239e-38  2.610139e-04  2.731209e-04  2.855940e-04
## ASV0753      3.121908e-38  1.935776e-04  2.027011e-04  2.120227e-04
## ASV2323      1.854846e-38  1.172369e-04  1.227267e-04  1.284798e-04
## ASV0881     -1.514337e-38 -9.169850e-05 -9.605742e-05 -1.003564e-04
## ASV3730     -3.925081e-38 -2.431407e-04 -2.545092e-04 -2.661938e-04
## ASV2685     -1.573644e-38 -9.355514e-05 -9.790698e-05 -1.022003e-04
## ASV3826     -7.386742e-39 -4.607649e-05 -4.815169e-05 -5.038190e-05
## ASV0689      2.754763e-39  2.087786e-05  2.196614e-05  2.316983e-05
## ASV4315     -5.081773e-38 -3.181240e-04 -3.330566e-04 -3.485226e-04
## ASV1239      2.647892e-38  1.548325e-04  1.617174e-04  1.686952e-04
## ASV3147     -8.147667e-39 -5.273082e-05 -5.522120e-05 -5.787259e-05
## ASV3454     -3.840625e-38 -2.376719e-04 -2.487590e-04 -2.601704e-04
## ASV4411     -2.207363e-38 -1.411304e-04 -1.478168e-04 -1.548353e-04
## ASV3007      4.665056e-38  2.846305e-04  2.978846e-04  3.113380e-04
## ASV6151     -3.826260e-38 -2.311648e-04 -2.417682e-04 -2.525848e-04
## ASV0834      3.834181e-38  2.417599e-04  2.531507e-04  2.649866e-04
## ASV1231      5.598695e-38  3.476271e-04  3.638867e-04  3.806329e-04
## ASV0643      4.726539e-38  2.931483e-04  3.068233e-04  3.209251e-04
## ASV0924      1.319149e-39  8.371462e-06  8.880343e-06  9.289912e-06
## ASV3238     -2.383924e-38 -1.450538e-04 -1.518144e-04 -1.586485e-04
## ASV1276     -2.750582e-38 -1.704933e-04 -1.783989e-04 -1.865927e-04
## ASV5503     -7.483618e-38 -4.610935e-04 -4.827858e-04 -5.048215e-04
## ASV0404      2.947214e-38  1.853304e-04  1.940365e-04  2.030864e-04
## ASV3430      2.721993e-39  2.718958e-05  2.858903e-05  3.042962e-05
## ASV5401     -3.145597e-38 -1.968745e-04 -2.060564e-04 -2.156208e-04
## ASV3426     -6.787422e-38 -4.199501e-04 -4.396863e-04 -4.598477e-04
## ASV0777      4.032554e-38  2.498649e-04  2.616390e-04  2.736540e-04
## ASV11093    -2.707956e-38 -1.680200e-04 -1.758582e-04 -1.839485e-04
## ASV2170     -2.409193e-38 -1.464803e-04 -1.533084e-04 -1.602061e-04
## ASV3861      2.234765e-38  1.331626e-04  1.392471e-04  1.453692e-04
## ASV1723     -3.913085e-38 -2.442268e-04 -2.556668e-04 -2.674976e-04
## ASV2460     -2.193632e-38 -1.381850e-04 -1.447009e-04 -1.514602e-04
## ASV1218     -3.292598e-38 -2.010199e-04 -2.103230e-04 -2.198323e-04
## ASV0436      2.946358e-39  1.331743e-05  1.384056e-05  1.422571e-05
## ASV0919      2.787107e-38  1.711740e-04  1.791669e-04  1.873197e-04
## ASV0577      1.197892e-38  7.322037e-05  7.667632e-05  8.014452e-05
## ASV2517      3.185481e-38  1.945977e-04  2.038982e-04  2.131155e-04
## ASV2628     -3.767529e-38 -2.362507e-04 -2.474003e-04 -2.588990e-04
## ASV1743     -3.405990e-38 -2.152824e-04 -2.255242e-04 -2.361009e-04
## ASV1678     -2.915553e-38 -1.856303e-04 -1.944034e-04 -2.035897e-04
## ASV0315      3.877318e-38  2.423240e-04  2.536752e-04  2.654343e-04
## ASV0253      1.830957e-38  1.129617e-04  1.183950e-04  1.238022e-04
## ASV1363      5.068679e-38  3.074871e-04  3.216947e-04  3.361258e-04
## ASV0995     -2.700195e-38 -1.686858e-04 -1.767244e-04 -1.849155e-04
## ASV4185     -1.260804e-38 -7.434328e-05 -7.777642e-05 -8.116074e-05
## ASV0782      2.405638e-38  1.534533e-04  1.607146e-04  1.683273e-04
## ASV3240     -2.904426e-38 -1.828621e-04 -1.914709e-04 -2.004176e-04
## ASV1392     -5.284547e-38 -3.318758e-04 -3.474738e-04 -3.636646e-04
## ASV8488     -1.200352e-38 -7.552078e-05 -7.899822e-05 -8.269069e-05
## ASV2814     -1.966965e-38 -1.231474e-04 -1.288803e-04 -1.348705e-04
## ASV0678     -3.908943e-38 -2.500311e-04 -2.619015e-04 -2.743377e-04
## ASV1295     -2.810054e-38 -1.754134e-04 -1.836099e-04 -1.921113e-04
## ASV7517     -1.780714e-38 -1.069464e-04 -1.119299e-04 -1.168989e-04
## ASV2996     -5.539339e-38 -3.421372e-04 -3.581900e-04 -3.745838e-04
## ASV2882     -5.239294e-38 -3.218551e-04 -3.367257e-04 -3.520480e-04
## ASV1317      3.154422e-38  1.976127e-04  2.069531e-04  2.165638e-04
## ASV9106     -5.235592e-38 -3.267484e-04 -3.420324e-04 -3.578601e-04
## ASV9688     -4.984323e-38 -3.108603e-04 -3.255079e-04 -3.405609e-04
## ASV6181     -4.990943e-38 -3.103362e-04 -3.249440e-04 -3.399245e-04
## ASV2936      1.175422e-39  9.038250e-06  9.512259e-06  1.003781e-05
## ASV0192     -2.128297e-38 -1.287285e-04 -1.344717e-04 -1.404788e-04
## ASV2509     -2.437611e-38 -1.562138e-04 -1.636759e-04 -1.714556e-04
## ASV0863      8.953436e-38  5.448168e-04  5.698605e-04  5.955230e-04
## ASV2762     -2.235036e-38 -1.396823e-04 -1.461929e-04 -1.529726e-04
## ASV4904     -4.781267e-38 -2.973558e-04 -3.113240e-04 -3.256787e-04
## ASV0571      1.671071e-38  1.015318e-04  1.065295e-04  1.113326e-04
## ASV13304    -6.609676e-39 -4.687697e-05 -4.918116e-05 -5.174039e-05
## ASV6863     -1.080011e-38 -6.750041e-05 -7.059813e-05 -7.387617e-05
## ASV4844      3.044650e-39  2.429113e-05  2.560657e-05  2.706548e-05
## ASV10779    -5.275301e-38 -3.265425e-04 -3.419023e-04 -3.575886e-04
## ASV7921     -4.416407e-38 -2.754550e-04 -2.883808e-04 -3.017197e-04
## ASV8458     -4.685252e-38 -2.878524e-04 -3.012329e-04 -3.149376e-04
## ASV2593     -7.190342e-39 -3.940412e-05 -4.114415e-05 -4.276659e-05
## ASV4410     -2.491929e-38 -1.561646e-04 -1.634415e-04 -1.710356e-04
## ASV0593      6.302221e-38  3.999655e-04  4.191121e-04  4.388331e-04
## ASV2669      3.842773e-38  2.344708e-04  2.452955e-04  2.563668e-04
## ASV0868     -4.923435e-38 -3.069522e-04 -3.213245e-04 -3.361777e-04
## ASV3123     -1.659969e-38 -1.074707e-04 -1.129689e-04 -1.183751e-04
## ASV3482     -2.027781e-38 -1.251315e-04 -1.309367e-04 -1.369208e-04
## ASV2552     -5.761207e-38 -3.463159e-04 -3.625599e-04 -3.786735e-04
## ASV0723      6.548178e-38  3.944410e-04  4.127884e-04  4.311765e-04
## ASV0526     -4.197203e-38 -2.611904e-04 -2.734074e-04 -2.860314e-04
## ASV4623     -1.871415e-38 -1.179297e-04 -1.234084e-04 -1.291751e-04
## ASV2070     -5.862263e-38 -3.641165e-04 -3.812087e-04 -3.987617e-04
## ASV1198      1.631923e-39  9.455039e-06  9.760426e-06  1.017174e-05
## ASV3034      2.758890e-39  1.560572e-05  1.603176e-05  1.669333e-05
## ASV1208     -7.021706e-39 -4.319985e-05 -4.525738e-05 -4.732411e-05
## ASV4860      9.235201e-39  5.882940e-05  6.170565e-05  6.461853e-05
## ASV2493     -1.811249e-38 -1.127878e-04 -1.180263e-04 -1.234776e-04
## ASV4217     -1.316017e-38 -7.808744e-05 -8.164926e-05 -8.521696e-05
## ASV1516     -6.710125e-39 -4.869653e-05 -5.115361e-05 -5.387270e-05
## ASV1186      2.158371e-38  1.347539e-04  1.409211e-04  1.474434e-04
## ASV1906     -1.864510e-38 -1.169099e-04 -1.225372e-04 -1.282402e-04
## ASV8220     -2.423491e-39 -1.816533e-05 -1.905412e-05 -2.009312e-05
## ASV4227     -4.296795e-38 -2.670673e-04 -2.795664e-04 -2.924491e-04
## ASV1013      2.595926e-38  1.671806e-04  1.751018e-04  1.834620e-04
## ASV7952     -2.810362e-38 -1.805732e-04 -1.892784e-04 -1.983045e-04
## ASV5923     -3.272647e-38 -2.059624e-04 -2.156447e-04 -2.257127e-04
## ASV0190     -4.176537e-38 -2.561965e-04 -2.681210e-04 -2.802966e-04
## ASV0491     -3.912354e-39 -2.771884e-05 -2.914572e-05 -3.066382e-05
## ASV9535     -1.764986e-38 -1.101035e-04 -1.152035e-04 -1.205276e-04
## ASV9947     -1.220474e-38 -8.190197e-05 -8.593190e-05 -9.020400e-05
## ASV6518     -1.156573e-38 -7.191753e-05 -7.531328e-05 -7.878825e-05
## ASV1741     -1.157422e-38 -7.371356e-05 -7.733438e-05 -8.099079e-05
## ASV1874      2.310758e-38  1.395646e-04  1.460938e-04  1.526138e-04
## ASV2150      6.286211e-39  3.949764e-05  4.140886e-05  4.333946e-05
## ASV5262     -1.199800e-38 -7.337375e-05 -7.676745e-05 -8.024382e-05
## ASV1729     -4.209242e-38 -2.638695e-04 -2.762569e-04 -2.891024e-04
## ASV1522     -7.010623e-39 -5.037918e-05 -5.305546e-05 -5.582639e-05
## ASV3250      9.367271e-39  5.663359e-05  5.919321e-05  6.183842e-05
## ASV4338     -4.281358e-38 -2.666399e-04 -2.791796e-04 -2.920727e-04
## ASV1386      5.091251e-38  3.183220e-04  3.332605e-04  3.487130e-04
## ASV0694     -5.280541e-39 -3.586574e-05 -3.751013e-05 -3.939614e-05
## ASV2026      3.751767e-39  2.822736e-05  2.966371e-05  3.128098e-05
## ASV0191     -3.483525e-38 -2.125785e-04 -2.224075e-04 -2.324476e-04
## ASV1641      1.607065e-38  1.029067e-04  1.079211e-04  1.130391e-04
## ASV1326      8.301652e-38  5.161503e-04  5.404710e-04  5.653833e-04
## ASV4786     -2.230045e-39 -1.536227e-05 -1.609469e-05 -1.691458e-05
## ASV0342      2.034193e-38  1.294865e-04  1.356055e-04  1.420108e-04
## ASV3025     -2.472267e-38 -1.504286e-04 -1.573835e-04 -1.644718e-04
## ASV6533     -4.202969e-38 -2.577286e-04 -2.696907e-04 -2.819370e-04
## ASV1898      4.594799e-38  2.880715e-04  3.016529e-04  3.156658e-04
## ASV1940      2.619137e-38  1.633855e-04  1.711288e-04  1.790393e-04
## ASV4968     -4.764662e-38 -2.983921e-04 -3.123486e-04 -3.268560e-04
## ASV3401     -2.516869e-38 -1.565666e-04 -1.638269e-04 -1.713816e-04
## ASV3211      1.451760e-38  9.371642e-05  9.819609e-05  1.028949e-04
## ASV1489     -6.682710e-38 -4.147101e-04 -4.341770e-04 -4.541449e-04
## ASV4139     -3.900016e-38 -2.430900e-04 -2.544670e-04 -2.662271e-04
## ASV6059     -4.113916e-38 -2.565738e-04 -2.685526e-04 -2.809724e-04
## ASV0918      1.093360e-38  6.510880e-05  6.808357e-05  7.107512e-05
## ASV1449      4.000056e-38  2.492890e-04  2.609644e-04  2.730240e-04
## ASV5652     -2.754336e-38 -1.712626e-04 -1.793864e-04 -1.876569e-04
## ASV4091     -1.943147e-39 -5.982020e-06 -6.134610e-06 -6.105732e-06
## ASV7638     -2.594639e-38 -1.593331e-04 -1.667115e-04 -1.742920e-04
## ASV6525     -3.706829e-38 -2.246156e-04 -2.349504e-04 -2.454935e-04
## ASV8959     -3.700607e-38 -2.315707e-04 -2.424571e-04 -2.537102e-04
## ASV0699      2.844740e-38  1.770863e-04  1.853707e-04  1.939122e-04
## ASV2925      3.452354e-38  2.169426e-04  2.271776e-04  2.377671e-04
## ASV0618      7.219910e-39  4.766619e-05  5.002519e-05  5.246478e-05
## ASV2083      5.018464e-39  3.326083e-05  3.494484e-05  3.666150e-05
## ASV6192     -4.556983e-38 -2.824383e-04 -2.956792e-04 -3.092613e-04
## ASV8640     -5.148762e-38 -3.193229e-04 -3.342709e-04 -3.496390e-04
## ASV1103      2.149890e-38  1.312781e-04  1.373343e-04  1.435463e-04
## ASV4240     -3.353191e-39 -1.598031e-05 -1.667639e-05 -1.720160e-05
## ASV2180      1.344607e-38  8.312271e-05  8.702725e-05  9.101621e-05
## ASV9157     -3.307252e-38 -2.047624e-04 -2.143102e-04 -2.241405e-04
## ASV1307      6.415343e-38  4.015145e-04  4.204117e-04  4.399265e-04
## ASV4960     -1.653270e-38 -1.004238e-04 -1.050491e-04 -1.097706e-04
## ASV3930     -1.406616e-38 -8.547606e-05 -8.941937e-05 -9.344439e-05
## ASV1200     -2.800829e-38 -1.756356e-04 -1.839455e-04 -1.924998e-04
## ASV4676     -1.441961e-38 -8.937840e-05 -9.356162e-05 -9.786067e-05
## ASV6993     -5.412234e-38 -3.323963e-04 -3.479324e-04 -3.637570e-04
## ASV4813     -2.092107e-38 -1.300788e-04 -1.360722e-04 -1.423402e-04
## ASV4364     -6.964206e-38 -4.286380e-04 -4.486678e-04 -4.691250e-04
## ASV0141      2.896778e-38  1.710394e-04  1.787975e-04  1.865853e-04
## ASV3509      1.642973e-38  1.071823e-04  1.124009e-04  1.178456e-04
## ASV2751      2.889865e-38  1.806039e-04  1.890864e-04  1.978511e-04
## ASV4913     -2.998635e-38 -1.852427e-04 -1.939084e-04 -2.027879e-04
## ASV0138      7.386171e-38  4.585610e-04  4.801881e-04  5.022958e-04
## ASV7697     -2.129214e-38 -1.292620e-04 -1.352235e-04 -1.412958e-04
## ASV1602      1.158982e-38  6.661215e-05  6.955973e-05  7.248385e-05
## ASV5976     -4.147301e-38 -2.570973e-04 -2.691043e-04 -2.814711e-04
## ASV7525     -4.279911e-38 -2.648960e-04 -2.772436e-04 -2.899620e-04
## ASV4961      1.936969e-38  1.196536e-04  1.253111e-04  1.310421e-04
## ASV2546      5.361939e-38  3.241216e-04  3.387858e-04  3.539327e-04
## ASV0721     -3.147587e-38 -1.951476e-04 -2.042741e-04 -2.136571e-04
## ASV0542      2.899991e-38  1.792970e-04  1.877279e-04  1.963337e-04
## ASV3865      1.882864e-38  1.149462e-04  1.202859e-04  1.257228e-04
## ASV5571     -3.451819e-38 -2.084702e-04 -2.181820e-04 -2.279241e-04
## ASV6804      3.511144e-39  2.552975e-05  2.682779e-05  2.825637e-05
## ASV4424      3.083974e-38  1.925458e-04  2.016097e-04  2.109376e-04
## ASV3395      2.417530e-38  1.424861e-04  1.488028e-04  1.552699e-04
## ASV2394     -3.040027e-38 -1.898807e-04 -1.987894e-04 -2.079978e-04
## ASV8629     -3.040027e-38 -1.898807e-04 -1.987743e-04 -2.079815e-04
## ASV1018      2.761158e-38  1.720351e-04  1.800355e-04  1.883524e-04
## ASV6139     -6.188109e-38 -3.849586e-04 -4.030683e-04 -4.216570e-04
## ASV10411    -3.161734e-38 -1.973956e-04 -2.066776e-04 -2.162479e-04
## ASV3992     -1.211140e-38 -7.672443e-05 -8.024430e-05 -8.401607e-05
## ASV7131     -2.355819e-39 -1.522148e-05 -1.582255e-05 -1.658133e-05
## ASV3729     -5.786726e-39 -3.274450e-05 -3.417555e-05 -3.558091e-05
## ASV2197     -6.990443e-39 -4.260302e-05 -4.452078e-05 -4.653001e-05
## ASV2426     -3.245921e-38 -1.987067e-04 -2.080004e-04 -2.174311e-04
## ASV3669     -2.919456e-38 -1.853044e-04 -1.940308e-04 -2.031719e-04
## ASV1820      1.591961e-38  9.797021e-05  1.025977e-04  1.072723e-04
## ASV7081     -2.810923e-38 -1.757156e-04 -1.839592e-04 -1.924906e-04
## ASV7872     -3.626603e-38 -2.237161e-04 -2.341177e-04 -2.448172e-04
## ASV1670     -4.820870e-39 -2.732090e-05 -2.849741e-05 -2.967204e-05
## ASV0712      3.344421e-38  2.153280e-04  2.256899e-04  2.364706e-04
## ASV0474      5.580430e-38  3.337950e-04  3.489150e-04  3.643422e-04
## ASV1196      5.269687e-38  3.289256e-04  3.442857e-04  3.602194e-04
## ASV0845      3.361745e-38  2.070936e-04  2.167379e-04  2.266392e-04
## ASV12393    -6.720861e-38 -4.192578e-04 -4.389982e-04 -4.593027e-04
## ASV5867     -2.570070e-38 -1.612027e-04 -1.688450e-04 -1.766980e-04
## ASV17619    -9.217831e-39 -6.059511e-05 -6.349302e-05 -6.659138e-05
## ASV4686     -2.262238e-38 -1.423333e-04 -1.490498e-04 -1.560102e-04
## ASV3520     -3.734315e-38 -2.321342e-04 -2.430046e-04 -2.542051e-04
## ASV10800    -6.063568e-38 -3.791161e-04 -3.969914e-04 -4.154011e-04
## ASV2706      5.356144e-38  3.362639e-04  3.520958e-04  3.684879e-04
## ASV1227     -7.836011e-39 -4.718554e-05 -4.938342e-05 -5.158206e-05
## ASV2621      4.856918e-38  3.082861e-04  3.229571e-04  3.381698e-04
## ASV0460      1.058262e-38  6.867972e-05  7.198703e-05  7.545256e-05
## ASV1069     -4.013579e-38 -2.524820e-04 -2.643826e-04 -2.767205e-04
## ASV6939     -3.781526e-38 -2.335146e-04 -2.444155e-04 -2.555993e-04
## ASV2862     -5.219391e-38 -3.242030e-04 -3.394497e-04 -3.550807e-04
## ASV1021     -3.120917e-38 -1.904943e-04 -1.994085e-04 -2.084198e-04
## ASV3845      2.398763e-38  1.504767e-04  1.575699e-04  1.648957e-04
## ASV0732      2.066603e-38  1.316825e-04  1.378914e-04  1.444111e-04
## ASV10731     1.656501e-38  1.018929e-04  1.066852e-04  1.115452e-04
## ASV3378      2.039950e-38  1.221437e-04  1.276924e-04  1.333376e-04
## ASV7154      2.327404e-39  1.023274e-05  1.065491e-05  1.092536e-05
## ASV9876      8.781653e-39  5.634575e-05  5.905129e-05  6.186114e-05
## ASV0631      4.002639e-38  2.533981e-04  2.653662e-04  2.778343e-04
## ASV13027    -3.040027e-38 -1.917868e-04 -2.007892e-04 -2.101882e-04
## ASV2497     -3.040027e-38 -1.917868e-04 -2.007739e-04 -2.101715e-04
## ASV3966     -4.276501e-38 -2.703421e-04 -2.830596e-04 -2.963365e-04
## ASV2574      2.681653e-38  1.619625e-04  1.695227e-04  1.770925e-04
## ASV0545     -2.358888e-38 -1.499638e-04 -1.570812e-04 -1.644811e-04
## ASV8453     -2.701459e-38 -1.702492e-04 -1.782500e-04 -1.865864e-04
## ASV0221     -1.436321e-38 -9.007618e-05 -9.431342e-05 -9.869976e-05
## ASV3305      1.903450e-38  1.213072e-04  1.271975e-04  1.332174e-04
## ASV2647     -1.382212e-38 -8.420160e-05 -8.807563e-05 -9.204488e-05
## ASV5789     -6.140388e-38 -3.880660e-04 -4.063723e-04 -4.254316e-04
## ASV1731     -2.088928e-38 -1.236289e-04 -1.293682e-04 -1.350188e-04
## ASV3857      8.970316e-39  5.463725e-05  5.716708e-05  5.974511e-05
## ASV0405      3.776918e-38  2.296122e-04  2.402861e-04  2.510931e-04
## ASV0094     -4.463495e-38 -2.639514e-04 -2.757301e-04 -2.877802e-04
## ASV0158     -2.203770e-39 -9.960242e-06 -1.029840e-05 -1.059245e-05
## ASV5507     -3.683166e-38 -2.293418e-04 -2.400269e-04 -2.511083e-04
## ASV1023     -1.262033e-39 -2.657244e-06 -2.657473e-06 -2.508781e-06
## ASV0488     -2.385343e-38 -1.490640e-04 -1.560438e-04 -1.632731e-04
## ASV1459      2.088266e-38  1.258465e-04  1.315737e-04  1.374414e-04
## ASV4349     -6.567031e-39 -3.795884e-05 -3.972643e-05 -4.141334e-05
## ASV1172      6.265962e-38  3.870047e-04  4.050819e-04  4.236188e-04
## ASV10187    -1.584248e-38 -1.012312e-04 -1.059901e-04 -1.110174e-04
## ASV7227      9.469253e-39  5.983662e-05  6.277531e-05  6.572220e-05
## ASV10340     9.107694e-39  5.857218e-05  6.144260e-05  6.437918e-05
## ASV10821    -1.761531e-38 -1.096192e-04 -1.146606e-04 -1.199467e-04
## ASV13810    -1.761531e-38 -1.096192e-04 -1.146521e-04 -1.199373e-04
## ASV3230     -1.410410e-38 -8.802138e-05 -9.204916e-05 -9.630440e-05
## ASV5524      1.733267e-39  9.224622e-06  9.757601e-06  1.013115e-05
## ASV8742     -1.761531e-38 -1.096192e-04 -1.146375e-04 -1.199210e-04
## ASV9188      3.992908e-38  2.424561e-04  2.537867e-04  2.651873e-04
## ASV4658      1.966638e-38  1.224225e-04  1.282782e-04  1.341991e-04
## ASV7889      2.499059e-38  1.499814e-04  1.568040e-04  1.637648e-04
## ASV1466      4.679535e-39  3.395611e-05  3.581877e-05  3.772160e-05
## ASV1424     -1.295084e-38 -7.166497e-05 -7.482777e-05 -7.782212e-05
## ASV0098     -2.976340e-38 -1.881115e-04 -1.970667e-04 -2.063001e-04
## ASV0067     -4.840102e-38 -3.014637e-04 -3.155641e-04 -3.301321e-04
## ASV9434     -2.022495e-38 -1.251776e-04 -1.311026e-04 -1.371173e-04
## ASV3270     -7.643380e-39 -4.919917e-05 -5.160656e-05 -5.406884e-05
## ASV4518     -3.490079e-38 -2.147222e-04 -2.247436e-04 -2.349854e-04
## ASV7661     -3.338061e-38 -2.023259e-04 -2.117491e-04 -2.212434e-04
## ASV4223      3.588748e-39  2.293499e-05  2.406129e-05  2.519858e-05
## ASV3481      2.611052e-38  1.709968e-04  1.792399e-04  1.879513e-04
## ASV7819     -5.088070e-38 -3.165658e-04 -3.314256e-04 -3.467171e-04
## ASV3095     -2.357105e-39 -1.371502e-05 -1.427221e-05 -1.487753e-05
## ASV4476     -1.013193e-38 -6.484205e-05 -6.787450e-05 -7.109885e-05
## ASV1713      3.181440e-38  1.916884e-04  2.005754e-04  2.095131e-04
## ASV11165    -8.468706e-39 -5.027694e-05 -5.252023e-05 -5.481483e-05
## ASV2179      6.285935e-38  3.920582e-04  4.105072e-04  4.294918e-04
## ASV3747      5.393274e-38  3.361877e-04  3.519593e-04  3.682225e-04
## ASV1410      3.553342e-39  1.856253e-05  1.932571e-05  2.003600e-05
## ASV6069     -3.385004e-38 -2.112077e-04 -2.210691e-04 -2.312968e-04
## ASV1939      8.979039e-39  5.826510e-05  6.108210e-05  6.402371e-05
## ASV7865     -5.284404e-38 -3.291990e-04 -3.446387e-04 -3.605537e-04
## ASV4488     -4.805763e-38 -3.021753e-04 -3.164111e-04 -3.311706e-04
## ASV0938      3.858265e-38  2.393716e-04  2.505557e-04  2.620782e-04
## ASV7852     -2.967785e-38 -1.819876e-04 -1.904824e-04 -1.991366e-04
## ASV2503     -2.209837e-39 -1.659019e-05 -1.740378e-05 -1.836021e-05
## ASV2993     -4.122813e-38 -2.588427e-04 -2.710070e-04 -2.836270e-04
## ASV3752     -5.274548e-39 -3.211412e-05 -3.356478e-05 -3.507738e-05
## ASV2557     -4.191849e-38 -2.635474e-04 -2.760664e-04 -2.889319e-04
## ASV6522     -9.007829e-39 -5.477398e-05 -5.730506e-05 -5.988232e-05
## ASV0088     -3.308933e-38 -1.972935e-04 -2.064256e-04 -2.155125e-04
## ASV7935     -2.642181e-38 -1.635758e-04 -1.712604e-04 -1.791202e-04
## ASV0942     -3.308049e-38 -2.079737e-04 -2.176955e-04 -2.278437e-04
## ASV7709     -4.010930e-38 -2.444468e-04 -2.558572e-04 -2.673999e-04
## ASV4588     -2.096652e-38 -1.253618e-04 -1.313071e-04 -1.371097e-04
## ASV5765     -5.601122e-38 -3.476535e-04 -3.639446e-04 -3.806882e-04
## ASV3562     -3.471049e-39 -1.834182e-05 -1.906265e-05 -1.977156e-05
## ASV9076     -4.259211e-38 -2.656545e-04 -2.780984e-04 -2.909613e-04
## ASV4707     -4.738833e-38 -2.962376e-04 -3.101912e-04 -3.245725e-04
## ASV2188      3.330284e-38  2.105652e-04  2.205422e-04  2.308899e-04
## ASV0613      5.627959e-39  3.884251e-05  4.064057e-05  4.270089e-05
## ASV0663     -2.128331e-38 -1.334838e-04 -1.397481e-04 -1.462489e-04
## ASV3361     -4.484393e-38 -2.666744e-04 -2.790375e-04 -2.912924e-04
## ASV1478      4.786493e-38  2.947571e-04  3.085124e-04  3.225855e-04
## ASV0213      2.649891e-38  1.636410e-04  1.713268e-04  1.791670e-04
## ASV7674     -1.468918e-38 -8.974063e-05 -9.387951e-05 -9.812733e-05
## ASV2137     -1.584706e-38 -9.625833e-05 -1.007163e-04 -1.052428e-04
## ASV8246     -1.303075e-38 -8.003929e-05 -8.377837e-05 -8.759305e-05
## ASV0047     -4.150135e-38 -2.538915e-04 -2.657137e-04 -2.777503e-04
## ASV6117      1.039659e-39  8.341143e-06  8.819576e-06  9.319976e-06
## ASV3349     -7.756286e-39 -4.842211e-05 -5.066403e-05 -5.300838e-05
## ASV10881    -2.662156e-38 -1.659203e-04 -1.736899e-04 -1.817129e-04
## ASV6979     -1.776051e-38 -1.119416e-04 -1.172010e-04 -1.226806e-04
## ASV7930     -3.502775e-38 -2.171707e-04 -2.272508e-04 -2.376924e-04
## ASV7322      1.160320e-38  7.268315e-05  7.618500e-05  7.972419e-05
## ASV4927     -5.597831e-39 -3.659796e-05 -3.829264e-05 -4.014876e-05
## ASV9054     -1.974473e-38 -1.213696e-04 -1.270452e-04 -1.328343e-04
## ASV2692     -1.415235e-38 -9.325971e-05 -9.787176e-05 -1.026270e-04
## ASV1666     -1.128303e-38 -6.512005e-05 -6.800987e-05 -7.088612e-05
## ASV4728      2.296259e-38  1.398116e-04  1.461468e-04  1.527348e-04
## ASV3097      1.455704e-38  9.256484e-05  9.695195e-05  1.015279e-04
## ASV4962     -1.109023e-38 -7.394556e-05 -7.757354e-05 -8.140323e-05
## ASV5057      1.774724e-38  1.134256e-04  1.188213e-04  1.244590e-04
## ASV2639      3.221944e-38  2.052521e-04  2.150166e-04  2.251795e-04
## ASV1808     -2.684481e-39 -2.363903e-05 -2.503301e-05 -2.653633e-05
## ASV6333     -5.520018e-39 -3.834703e-05 -4.022320e-05 -4.228480e-05
## ASV4328     -1.484326e-38 -9.219545e-05 -9.651742e-05 -1.009611e-04
## ASV7707     -4.416514e-38 -2.716547e-04 -2.844220e-04 -2.973783e-04
## ASV11022    -4.299931e-38 -2.637218e-04 -2.760366e-04 -2.885750e-04
## ASV1469     -8.052818e-39 -4.942537e-05 -5.161795e-05 -5.396413e-05
## ASV3919     -1.414495e-38 -9.051565e-05 -9.480915e-05 -9.930821e-05
## ASV4038     -2.976963e-38 -1.842646e-04 -1.929572e-04 -2.018117e-04
## ASV4048      9.918914e-39  6.539359e-05  6.858578e-05  7.193452e-05
## ASV0634      1.196956e-38  7.595324e-05  7.953748e-05  8.328684e-05
## ASV1852     -3.229859e-38 -2.067775e-04 -2.166479e-04 -2.269402e-04
## ASV2505      2.518163e-38  1.561750e-04  1.634463e-04  1.709628e-04
## ASV1762     -3.875928e-38 -2.398112e-04 -2.509575e-04 -2.624645e-04
## ASV3761     -3.280191e-38 -2.034671e-04 -2.129224e-04 -2.227104e-04
## ASV0775     -5.573295e-38 -3.450361e-04 -3.611855e-04 -3.777554e-04
## ASV10911    -4.097607e-38 -2.531088e-04 -2.649103e-04 -2.770376e-04
## ASV1339     -7.150682e-39 -4.325532e-05 -4.515354e-05 -4.716675e-05
## ASV5214     -9.525510e-39 -5.784683e-05 -6.046549e-05 -6.317816e-05
## ASV4945      1.063081e-38  6.677125e-05  6.995175e-05  7.320830e-05
## ASV5624     -9.451872e-39 -5.504897e-05 -5.749199e-05 -5.994980e-05
## ASV3429     -5.411225e-39 -3.129353e-05 -3.280992e-05 -3.420863e-05
## ASV8416     -3.964180e-39 -2.866923e-05 -3.015641e-05 -3.175097e-05
## ASV2400     -5.014752e-38 -3.120316e-04 -3.265810e-04 -3.416430e-04
## ASV3388     -1.585134e-38 -1.014405e-04 -1.062274e-04 -1.112690e-04
## ASV7089      1.078438e-38  6.386509e-05  6.675945e-05  6.966978e-05
## ASV3396     -1.706649e-38 -1.041804e-04 -1.090397e-04 -1.139607e-04
## ASV0343      2.253455e-38  1.477895e-04  1.549308e-04  1.624655e-04
## ASV5505     -3.002117e-38 -1.888784e-04 -1.977438e-04 -2.069745e-04
## ASV6721     -1.388994e-38 -8.897990e-05 -9.315621e-05 -9.758549e-05
## ASV0537      1.083073e-38  7.668687e-05  8.060197e-05  8.479140e-05
## ASV7753     -3.924621e-38 -2.452021e-04 -2.566482e-04 -2.685380e-04
## ASV5022     -2.426241e-39 -1.928400e-05 -2.032874e-05 -2.147642e-05
## ASV1073      5.477660e-38  3.424264e-04  3.585078e-04  3.751265e-04
## ASV1347     -1.843176e-53 -7.378587e-07 -7.505202e-07 -8.295470e-07
## ASV15032     1.716686e-38  1.038526e-04  1.086769e-04  1.135331e-04
## ASV18213    -1.843176e-53 -7.378641e-07 -7.572392e-07 -8.365261e-07
## ASV20691     1.380943e-38  8.745635e-05  9.163427e-05  9.593565e-05
## ASV4260     -7.189165e-39 -4.502563e-05 -4.712375e-05 -4.931895e-05
## ASV4923      1.201268e-38  7.597138e-05  7.959908e-05  8.332917e-05
## ASV7995     -1.843176e-53 -7.378612e-07 -7.656641e-07 -8.454530e-07
## ASV8960      2.476201e-38  1.535265e-04  1.607482e-04  1.681293e-04
## ASV10682     1.973690e-38  1.171999e-04  1.225136e-04  1.278740e-04
## ASV11911    -1.843176e-53 -7.378788e-07 -7.817363e-07 -8.625030e-07
## ASV14296     3.029779e-38  1.849851e-04  1.935955e-04  2.023389e-04
## ASV2314      1.571118e-38  1.049800e-04  1.101566e-04  1.156044e-04
## ASV3819      1.953065e-38  1.194147e-04  1.249598e-04  1.306079e-04
## ASV4517     -8.601489e-53 -7.378795e-07 -8.057896e-07 -8.883055e-07
## ASV8941      3.624761e-38  2.277662e-04  2.384662e-04  2.495778e-04
## ASV1444      8.601489e-53  7.378818e-07  8.170046e-07  9.005041e-07
## ASV5959      6.784199e-39  4.167676e-05  4.359344e-05  4.556887e-05
## ASV3623     -1.724633e-38 -1.055589e-04 -1.103678e-04 -1.153716e-04
## ASV0260      2.024028e-38  1.269794e-04  1.329433e-04  1.391305e-04
## ASV4401     -1.204246e-38 -8.304616e-05 -8.737652e-05 -9.178812e-05
## ASV2891     -4.408109e-38 -2.770481e-04 -2.900933e-04 -3.036208e-04
## ASV2778     -9.969306e-39 -6.236515e-05 -6.529702e-05 -6.832813e-05
## ASV8744      2.051786e-38  1.227527e-04  1.282949e-04  1.339719e-04
## ASV1079      4.153702e-38  2.518380e-04  2.632976e-04  2.751136e-04
## ASV19688     2.500328e-39  1.859260e-05  1.959729e-05  2.065919e-05
## ASV4039      4.355508e-39  3.075374e-05  3.236437e-05  3.404862e-05
## ASV4982     -3.040027e-38 -1.885135e-04 -1.972423e-04 -2.063063e-04
## ASV1071     -3.040027e-38 -1.885135e-04 -1.972276e-04 -2.062902e-04
## ASV7666     -3.040027e-38 -1.885135e-04 -1.972128e-04 -2.062741e-04
## ASV0502      4.220335e-38  2.635080e-04  2.758206e-04  2.885891e-04
## ASV3624     -3.040027e-38 -1.887821e-04 -1.974954e-04 -2.065817e-04
## ASV0403      4.682997e-39  2.715393e-05  2.824295e-05  2.944286e-05
## ASV4939     -3.040027e-38 -1.887821e-04 -1.974791e-04 -2.065638e-04
## ASV6297     -3.605016e-38 -2.258223e-04 -2.364340e-04 -2.474168e-04
## ASV6343      3.400843e-38  2.022040e-04  2.113099e-04  2.205898e-04
## ASV0954     -7.556871e-39 -4.281063e-05 -4.472364e-05 -4.656755e-05
## ASV10225    -1.281403e-38 -8.198314e-05 -8.596990e-05 -9.004248e-05
## ASV1584      5.284594e-38  3.280657e-04  3.433894e-04  3.591889e-04
## ASV1803      2.011038e-38  1.208411e-04  1.263472e-04  1.319497e-04
## ASV2576     -5.284594e-38 -3.280657e-04 -3.433562e-04 -3.591531e-04
## ASV3252      3.409593e-38  2.131847e-04  2.232321e-04  2.335818e-04
## ASV3463     -5.284594e-38 -3.280657e-04 -3.433290e-04 -3.591236e-04
## ASV3822     -3.957697e-38 -2.491155e-04 -2.608625e-04 -2.730481e-04
## ASV4926     -2.238915e-38 -1.330036e-04 -1.391014e-04 -1.451965e-04
## ASV5564     -1.365277e-38 -8.479790e-05 -8.874238e-05 -9.282992e-05
## ASV5595     -8.015824e-39 -4.952602e-05 -5.181020e-05 -5.418404e-05
## ASV16463    -3.040027e-38 -1.909549e-04 -1.999117e-04 -2.092282e-04
## ASV6277      2.997969e-38  1.905645e-04  1.996316e-04  2.090419e-04
## ASV1344      3.040027e-38  1.909549e-04  1.999046e-04  2.092204e-04
## ASV1869      2.027390e-38  1.221720e-04  1.278721e-04  1.335651e-04
## ASV8155     -1.751049e-38 -1.048286e-04 -1.096710e-04 -1.145192e-04
## ASV2502     -3.121633e-38 -1.930013e-04 -2.020771e-04 -2.113357e-04
## ASV6742     -1.036673e-38 -6.063499e-05 -6.325798e-05 -6.597718e-05
## ASV3124     -2.035493e-38 -1.253401e-04 -1.312519e-04 -1.372491e-04
## ASV17042    -3.538879e-38 -2.195174e-04 -2.297631e-04 -2.403238e-04
## ASV0248      4.951509e-38  3.044588e-04  3.187058e-04  3.332258e-04
## ASV4557      7.240290e-39  5.129801e-05  5.380679e-05  5.659842e-05
## ASV3507     -5.318894e-38 -3.334160e-04 -3.490772e-04 -3.653067e-04
## ASV1870      3.925686e-39  2.451452e-05  2.565442e-05  2.684114e-05
## ASV2447     -2.538170e-38 -1.605589e-04 -1.681094e-04 -1.760053e-04
## ASV0347      4.138318e-38  2.607439e-04  2.730120e-04  2.857775e-04
## ASV1855     -1.910553e-38 -1.197535e-04 -1.253054e-04 -1.311309e-04
## ASV0568      1.460272e-38  9.006745e-05  9.426803e-05  9.857667e-05
## ASV1620     -2.568366e-38 -1.604123e-04 -1.678007e-04 -1.755654e-04
## ASV0101     -2.210653e-38 -1.302780e-04 -1.360795e-04 -1.419912e-04
## ASV7751      1.844488e-38  1.202780e-04  1.260394e-04  1.321393e-04
## ASV9033     -3.491267e-38 -2.191900e-04 -2.294851e-04 -2.401727e-04
## ASV3438     -9.992641e-39 -6.354684e-05 -6.650713e-05 -6.964670e-05
## ASV0637     -3.283357e-38 -2.047400e-04 -2.143703e-04 -2.242803e-04
## ASV1181     -2.405905e-38 -1.512350e-04 -1.583709e-04 -1.657528e-04
## ASV13480    -3.040027e-38 -1.905209e-04 -1.994803e-04 -2.087521e-04
## ASV14220    -3.040027e-38 -1.905209e-04 -1.994651e-04 -2.087356e-04
## ASV1448     -2.207886e-38 -1.391295e-04 -1.456730e-04 -1.524831e-04
## ASV1457      2.119314e-38  1.284985e-04  1.344113e-04  1.404352e-04
## ASV1645      1.447726e-38  9.222062e-05  9.660243e-05  1.011672e-04
## ASV2300     -2.015774e-38 -1.242406e-04 -1.300007e-04 -1.359325e-04
## ASV2533      3.110348e-38  1.911761e-04  2.001034e-04  2.092099e-04
## ASV5059      8.200787e-39  4.739254e-05  4.941722e-05  5.150959e-05
## ASV8871     -3.040027e-38 -1.905209e-04 -1.994593e-04 -2.087290e-04
## ASV1289     -3.309782e-38 -2.042898e-04 -2.137817e-04 -2.235579e-04
## ASV3983     -1.365234e-38 -8.689047e-05 -9.096320e-05 -9.525713e-05
## ASV10323    -1.041118e-38 -6.874318e-05 -7.202488e-05 -7.554881e-05
## ASV13279    -3.040027e-38 -1.905209e-04 -1.994209e-04 -2.086870e-04
## ASV7149     -3.040027e-38 -1.905209e-04 -1.994058e-04 -2.086706e-04
## ASV1691      5.674663e-39  3.634495e-05  3.797525e-05  3.978105e-05
## ASV1649      1.476393e-38  9.356678e-05  9.797366e-05  1.025752e-04
## ASV10120     4.218114e-39  2.746433e-05  2.876642e-05  3.015625e-05
## ASV8285     -3.811186e-38 -2.425896e-04 -2.541507e-04 -2.661480e-04
## ASV0037     -3.302277e-38 -2.086718e-04 -2.186016e-04 -2.288527e-04
## ASV1770      8.758316e-39  5.461805e-05  5.715598e-05  5.980205e-05
## ASV2252      8.374943e-39  5.226610e-05  5.468663e-05  5.721327e-05
## ASV7580      3.475586e-38  2.115718e-04  2.213089e-04  2.312775e-04
## ASV5643     -3.085640e-38 -1.928210e-04 -2.018508e-04 -2.112061e-04
## ASV2722     -9.384900e-39 -6.168167e-05 -6.465802e-05 -6.781417e-05
## ASV2662     -2.105348e-38 -1.322625e-04 -1.384446e-04 -1.449001e-04
## ASV0479     -4.905052e-38 -3.022591e-04 -3.162551e-04 -3.306940e-04
## ASV2009     -5.226628e-38 -3.183983e-04 -3.331569e-04 -3.481742e-04
## ASV3731     -3.492426e-38 -2.144214e-04 -2.244078e-04 -2.346096e-04
## ASV5497     -4.276841e-38 -2.650976e-04 -2.774693e-04 -2.902182e-04
## ASV6647      2.236488e-39  1.182197e-05  1.238654e-05  1.284745e-05
## ASV8974     -3.166542e-38 -1.954898e-04 -2.045657e-04 -2.139204e-04
## ASV15527     2.932468e-39  1.714342e-05  1.796233e-05  1.873531e-05
## ASV6705     -1.804951e-38 -1.197541e-04 -1.255638e-04 -1.317413e-04
## ASV0354      3.996752e-38  2.497325e-04  2.614194e-04  2.735321e-04
## ASV2707      9.718478e-39  5.743385e-05  5.995803e-05  6.256400e-05
## ASV11167    -5.281250e-38 -3.282342e-04 -3.436250e-04 -3.594538e-04
## ASV6393     -4.189279e-38 -2.611269e-04 -2.733810e-04 -2.860152e-04
## ASV3808     -3.059405e-38 -1.863782e-04 -1.952193e-04 -2.040274e-04
## ASV9337      4.645467e-39  2.605494e-05  2.719232e-05  2.829562e-05
## ASV5043     -4.300017e-38 -2.679127e-04 -2.804645e-04 -2.934193e-04
## ASV4189     -1.703631e-39 -8.022177e-06 -8.292015e-06 -8.540443e-06
## ASV1304     -1.760863e-38 -1.027025e-04 -1.071859e-04 -1.117856e-04
## ASV2105     -2.248068e-38 -1.404589e-04 -1.469656e-04 -1.537739e-04
## ASV2421     -7.654459e-39 -4.881651e-05 -5.106578e-05 -5.348460e-05
## ASV3170      3.558411e-38  2.241943e-04  2.347933e-04  2.457706e-04
## ASV5036      4.836028e-38  3.007073e-04  3.148170e-04  3.293301e-04
## ASV2286      3.040027e-38  1.897510e-04  1.985626e-04  2.077516e-04
## ASV3363      2.977992e-38  1.893119e-04  1.983785e-04  2.077394e-04
## ASV5759     -2.580681e-39 -1.740408e-05 -1.820321e-05 -1.911424e-05
## ASV5440     -2.030115e-38 -1.310067e-04 -1.372696e-04 -1.438424e-04
## ASV2050      3.623413e-38  2.186938e-04  2.287286e-04  2.389201e-04
## ASV4478      2.428010e-38  1.550368e-04  1.624293e-04  1.701267e-04
## ASV5725     -2.724618e-38 -1.677015e-04 -1.754074e-04 -1.834048e-04
## ASV1600     -6.457862e-39 -4.767228e-05 -5.015940e-05 -5.285313e-05
## ASV1654     -4.841405e-38 -2.984656e-04 -3.122540e-04 -3.265165e-04
## ASV3781     -2.119260e-38 -1.289778e-04 -1.348333e-04 -1.409007e-04
## ASV7144     -1.828655e-38 -1.106699e-04 -1.158356e-04 -1.210184e-04
## ASV12710    -7.391208e-39 -4.115443e-05 -4.288777e-05 -4.461537e-05
## ASV3317      2.424066e-38  1.503901e-04  1.573732e-04  1.646155e-04
## ASV3249     -4.736936e-38 -2.945087e-04 -3.082004e-04 -3.223989e-04
## ASV0669     -3.034387e-38 -1.840377e-04 -1.924693e-04 -2.011038e-04
## ASV0893      1.761531e-38  1.086409e-04  1.137095e-04  1.189058e-04
## ASV11060    -1.761531e-38 -1.086409e-04 -1.137009e-04 -1.188966e-04
## ASV3207      5.895205e-38  3.738704e-04  3.915441e-04  4.099673e-04
## ASV3498     -1.761531e-38 -1.086409e-04 -1.136997e-04 -1.188954e-04
## ASV4358      1.109389e-38  6.881146e-05  7.204995e-05  7.536149e-05
## ASV4806      2.999849e-38  1.863527e-04  1.951439e-04  2.041281e-04
## ASV4941      1.761531e-38  1.086409e-04  1.136950e-04  1.188903e-04
## ASV6998      5.234933e-39  3.253659e-05  3.405861e-05  3.562454e-05
## ASV7327     -1.761531e-38 -1.086409e-04 -1.136885e-04 -1.188833e-04
## ASV5112      3.482204e-38  2.192409e-04  2.295998e-04  2.403179e-04
## ASV5345     -1.761531e-38 -1.086409e-04 -1.136728e-04 -1.188664e-04
## ASV8911     -1.761531e-38 -1.086409e-04 -1.136643e-04 -1.188572e-04
## ASV5061      4.085493e-38  2.536328e-04  2.655230e-04  2.777387e-04
## ASV1968     -3.222116e-39 -2.212820e-05 -2.325291e-05 -2.443364e-05
## ASV4669     -1.761531e-38 -1.086409e-04 -1.136485e-04 -1.188401e-04
## ASV6209     -6.915139e-39 -4.043491e-05 -4.220175e-05 -4.401238e-05
## ASV6938      3.517061e-38  2.159300e-04  2.259522e-04  2.362210e-04
## ASV6987      2.003492e-38  1.201685e-04  1.256870e-04  1.312542e-04
## ASV7842     -1.761531e-38 -1.086409e-04 -1.136444e-04 -1.188355e-04
## ASV17950     1.404325e-53  4.153973e-08  7.060140e-08  7.535778e-08
## ASV3380     -5.168331e-38 -3.164074e-04 -3.311699e-04 -3.461813e-04
## ASV13740    -4.294788e-38 -2.693768e-04 -2.820232e-04 -2.951443e-04
## ASV4313     -2.528080e-38 -1.581179e-04 -1.654718e-04 -1.731434e-04
## ASV3891     -2.793767e-38 -1.646700e-04 -1.723195e-04 -1.798107e-04
## ASV3322     -3.070413e-38 -1.913492e-04 -2.002732e-04 -2.095279e-04
## ASV1668     -5.073826e-39 -3.295342e-05 -3.445860e-05 -3.612549e-05
## ASV1739      1.243720e-38  7.424952e-05  7.757296e-05  8.098769e-05
## ASV3194      2.457088e-38  1.525291e-04  1.596033e-04  1.669464e-04
## ASV0071     -3.885679e-38 -2.304160e-04 -2.406914e-04 -2.512234e-04
## ASV0695      1.737182e-38  1.105566e-04  1.157141e-04  1.211627e-04
## ASV3835     -1.421637e-38 -8.662171e-05 -9.066189e-05 -9.474988e-05
## ASV1876      1.410429e-38  8.928754e-05  9.353481e-05  9.792487e-05
## ASV4892     -4.246804e-38 -2.653634e-04 -2.778638e-04 -2.907405e-04
## ASV1212     -1.477617e-38 -9.152865e-05 -9.575942e-05 -1.001579e-04
## ASV2640      3.628634e-40  1.380846e-06  1.346229e-06  1.361058e-06
## ASV7236     -4.178066e-38 -2.623329e-04 -2.746554e-04 -2.874474e-04
## ASV2353     -1.136627e-38 -7.330739e-05 -7.677952e-05 -8.045591e-05
## ASV0276      5.297941e-38  3.195025e-04  3.345086e-04  3.494365e-04
## ASV2262     -1.567746e-38 -9.738002e-05 -1.018208e-04 -1.065136e-04
## ASV11201    -1.012069e-38 -6.505832e-05 -6.812014e-05 -7.136842e-05
## ASV0665      4.368155e-39  2.630232e-05  2.750677e-05  2.873579e-05
## ASV5238      5.689398e-39  2.707901e-05  2.796191e-05  2.882414e-05
## ASV6885     -2.331070e-38 -1.441928e-04 -1.508976e-04 -1.578152e-04
## ASV1844      8.573873e-39  5.835171e-05  6.118078e-05  6.426061e-05
## ASV0379      3.040027e-38  1.881053e-04  1.968199e-04  2.058426e-04
## ASV1040     -9.902104e-39 -5.901721e-05 -6.163289e-05 -6.434318e-05
## ASV7913     -1.752280e-38 -1.091092e-04 -1.141778e-04 -1.194457e-04
## ASV1197     -3.040027e-38 -1.881053e-04 -1.967934e-04 -2.058138e-04
## ASV5918      1.299749e-38  8.135371e-05  8.522954e-05  8.918852e-05
## ASV8045      6.221209e-39  4.193262e-05  4.406153e-05  4.625739e-05
## ASV16458    -3.472051e-39 -1.902343e-05 -1.977009e-05 -2.054654e-05
## ASV10827    -3.040027e-38 -1.881053e-04 -1.967829e-04 -2.058023e-04
## ASV3658     -3.040027e-38 -1.881053e-04 -1.967682e-04 -2.057863e-04
## ASV0073     -6.214215e-38 -3.897822e-04 -4.080578e-04 -4.270334e-04
## ASV1951     -1.155586e-38 -7.843090e-05 -8.238386e-05 -8.651478e-05
## ASV7630     -3.993133e-38 -2.479903e-04 -2.596152e-04 -2.715665e-04
## ASV9449     -2.069183e-38 -1.320937e-04 -1.384554e-04 -1.450124e-04
## ASV3944      4.302148e-38  2.663418e-04  2.787381e-04  2.915314e-04
## ASV1520     -5.841721e-38 -3.603328e-04 -3.770869e-04 -3.943150e-04
## ASV0307      4.418851e-38  2.782776e-04  2.914286e-04  3.050469e-04
## ASV12731    -1.095031e-38 -7.059797e-05 -7.391422e-05 -7.745308e-05
## ASV0282      4.436702e-38  2.794136e-04  2.925968e-04  3.062694e-04
## ASV2646      4.152743e-38  2.509374e-04  2.625104e-04  2.742390e-04
## ASV3536      3.198782e-38  1.993123e-04  2.086419e-04  2.182783e-04
## ASV10089    -3.040027e-38 -1.836718e-04 -1.921487e-04 -2.007331e-04
## ASV1185      3.040027e-38  1.836717e-04  1.921343e-04  2.007179e-04
## ASV1452      3.040027e-38  1.836717e-04  1.921201e-04  2.007027e-04
## ASV1700      3.040027e-38  1.836717e-04  1.921058e-04  2.006875e-04
## ASV6948     -3.040027e-38 -1.836717e-04 -1.920916e-04 -2.006723e-04
## ASV0389     -3.943704e-38 -2.396933e-04 -2.507067e-04 -2.619775e-04
## ASV11884    -5.253884e-40  1.887392e-06  2.177311e-06  2.536095e-06
## ASV23165    -3.040027e-38 -1.836716e-04 -1.920605e-04 -2.006392e-04
## ASV2841      3.040027e-38  1.836716e-04  1.920464e-04  2.006240e-04
## ASV2949      3.040027e-38  1.836716e-04  1.920323e-04  2.006088e-04
## ASV4037      3.040027e-38  1.836716e-04  1.920181e-04  2.005936e-04
## ASV4477      3.040027e-38  1.836715e-04  1.920041e-04  2.005784e-04
## ASV4496      3.040027e-38  1.836715e-04  1.919900e-04  2.005633e-04
## ASV5784     -3.040027e-38 -1.836715e-04 -1.919760e-04 -2.005481e-04
## ASV6035      1.907164e-40  4.395966e-06  4.807635e-06  5.194309e-06
## ASV6232     -3.045296e-38 -1.839988e-04 -1.923052e-04 -2.008920e-04
## ASV1818      3.040027e-38  1.836715e-04  1.919485e-04  2.005183e-04
## ASV2595      3.040027e-38  1.836714e-04  1.919345e-04  2.005031e-04
## ASV2788     -3.942844e-39 -2.394801e-05 -2.519668e-05 -2.633223e-05
## ASV5018      3.040027e-38  1.836714e-04  1.919219e-04  2.004892e-04
## ASV0127      3.946275e-38  2.482308e-04  2.599069e-04  2.720360e-04
## ASV1527      6.855792e-40  5.752538e-06  6.058213e-06  6.411032e-06
## ASV1055      2.270216e-38  1.409741e-04  1.475074e-04  1.542930e-04
## ASV4791      1.644295e-38  9.131001e-05  9.517163e-05  9.900267e-05
## ASV0859      1.646178e-38  1.008136e-04  1.054603e-04  1.102364e-04
## ASV12971    -4.307029e-38 -2.686408e-04 -2.811692e-04 -2.941669e-04
## ASV16856    -4.307029e-38 -2.686408e-04 -2.811480e-04 -2.941438e-04
## ASV7321     -3.513345e-38 -2.194858e-04 -2.296870e-04 -2.403210e-04
## ASV8780     -4.307029e-38 -2.686407e-04 -2.811100e-04 -2.941024e-04
## ASV1569      3.172041e-38  1.968608e-04  2.059894e-04  2.154612e-04
## ASV3696      5.300945e-39  3.170304e-05  3.321207e-05  3.467750e-05
## ASV0624      5.823903e-38  3.601778e-04  3.769539e-04  3.942383e-04
## ASV0495      3.590085e-38  2.196109e-04  2.298681e-04  2.402786e-04
## ASV16971    -1.761531e-38 -1.097604e-04 -1.148405e-04 -1.201437e-04
## ASV6535      9.535005e-39  6.230118e-05  6.536808e-05  6.853862e-05
## ASV1897      4.203325e-38  2.577896e-04  2.697373e-04  2.819901e-04
## ASV2631     -4.658649e-39 -3.305485e-05 -3.476329e-05 -3.657832e-05
## ASV6204      1.368773e-38  8.641016e-05  9.052689e-05  9.476468e-05
## ASV3312     -2.647859e-38 -1.655328e-04 -1.732653e-04 -1.813006e-04
## ASV3360      1.640577e-38  1.046865e-04  1.097151e-04  1.149091e-04
## ASV3907      7.881744e-39  5.085462e-05  5.329517e-05  5.584468e-05
## ASV6090      8.337117e-39  5.234602e-05  5.486479e-05  5.741667e-05
## ASV8652     -1.007941e-38 -6.049137e-05 -6.322716e-05 -6.602966e-05
## ASV11129    -1.761531e-38 -1.086439e-04 -1.136612e-04 -1.188561e-04
## ASV11073    -1.761531e-38 -1.086439e-04 -1.136527e-04 -1.188469e-04
## ASV1840      5.907088e-38  3.635740e-04  3.804621e-04  3.978021e-04
## ASV2298      2.253527e-38  1.373399e-04  1.435990e-04  1.500772e-04
## ASV2420      5.218580e-38  3.255549e-04  3.408462e-04  3.566138e-04
## ASV6474      6.881894e-39  4.447268e-05  4.659975e-05  4.882952e-05
## ASV8475     -1.761531e-38 -1.086439e-04 -1.136414e-04 -1.188346e-04
## ASV8679     -1.761531e-38 -1.086439e-04 -1.136329e-04 -1.188254e-04
## ASV6527      1.636266e-38  1.033785e-04  1.082870e-04  1.133640e-04
## ASV2504     -2.342292e-39 -1.701805e-05 -1.805959e-05 -1.902135e-05
## ASV1093     -1.855121e-38 -1.151657e-04 -1.206555e-04 -1.262068e-04
## ASV0994      2.435005e-38  1.518091e-04  1.588878e-04  1.662320e-04
## ASV0092     -3.956158e-38 -2.502154e-04 -2.620735e-04 -2.743717e-04
## ASV2619      8.953795e-39  5.682656e-05  5.950699e-05  6.230727e-05
## ASV0121      5.274311e-38  3.169921e-04  3.315391e-04  3.462633e-04
## ASV0932      1.695377e-38  1.087630e-04  1.140434e-04  1.194699e-04
## ASV5229      2.968493e-38  1.819664e-04  1.904423e-04  1.990838e-04
## ASV6737      2.965703e-38  1.854651e-04  1.941825e-04  2.031863e-04
## ASV11213    -4.307029e-38 -2.617404e-04 -2.738407e-04 -2.861503e-04
## ASV1151      8.692754e-38  5.397372e-04  5.649492e-04  5.909473e-04
## ASV3813      4.616307e-38  2.819419e-04  2.950099e-04  3.083429e-04
## ASV5566      8.269295e-39  5.835884e-05  6.123636e-05  6.441439e-05
## ASV7529     -4.307029e-38 -2.617404e-04 -2.738094e-04 -2.861171e-04
## ASV2193      5.998846e-38  3.774299e-04  3.951882e-04  4.136305e-04
## ASV2349      5.562478e-38  3.470905e-04  3.633022e-04  3.801135e-04
## ASV2387      5.028924e-38  3.048239e-04  3.188197e-04  3.331089e-04
## ASV2699      3.988293e-38  2.535973e-04  2.656059e-04  2.781403e-04
## ASV3353      5.360171e-38  3.309599e-04  3.463798e-04  3.622217e-04
## ASV3621      2.915574e-38  1.762725e-04  1.843890e-04  1.926314e-04
## ASV3848      4.837844e-39  3.128401e-05  3.276725e-05  3.434004e-05
## ASV4440     -6.352699e-41  4.050718e-06  4.405358e-06  4.837522e-06
## ASV4751      5.590983e-38  3.488976e-04  3.652461e-04  3.821470e-04
## ASV5115      2.366276e-38  1.495516e-04  1.565516e-04  1.638856e-04
## ASV5850     -4.307029e-38 -2.617404e-04 -2.737556e-04 -2.860594e-04
## ASV6293      2.597579e-38  1.618460e-04  1.694300e-04  1.772549e-04
## ASV6513      1.071533e-38  7.121434e-05  7.468335e-05  7.836314e-05
## ASV7628     -4.307029e-38 -2.617403e-04 -2.737388e-04 -2.860415e-04
## ASV7658      2.525182e-38  1.598704e-04  1.674603e-04  1.753190e-04
## ASV0776     -5.032782e-38 -3.078551e-04 -3.221308e-04 -3.367132e-04
## ASV10227    -4.307029e-38 -2.617403e-04 -2.737206e-04 -2.860220e-04
## ASV11965    -4.307029e-38 -2.617403e-04 -2.737004e-04 -2.860002e-04
## ASV1270     -1.490230e-38 -8.860726e-05 -9.257232e-05 -9.662802e-05
## ASV13123    -3.272211e-38 -1.976928e-04 -2.066335e-04 -2.158574e-04
## ASV5828      4.307029e-38  2.617402e-04  2.736608e-04  2.859574e-04
## ASV5920     -4.307029e-38 -2.617402e-04 -2.736406e-04 -2.859357e-04
## ASV6071      3.957039e-38  2.486370e-04  2.603211e-04  2.724560e-04
## ASV6723     -2.495385e-39 -1.253460e-05 -1.295282e-05 -1.339546e-05
## ASV6727     -4.307029e-38 -2.617402e-04 -2.736154e-04 -2.859083e-04
## ASV7759     -4.307029e-38 -2.617402e-04 -2.735954e-04 -2.858865e-04
## ASV0733      2.834952e-39  1.855604e-05  1.931494e-05  2.025628e-05
## ASV1655     -5.682449e-39 -3.967576e-05 -4.158858e-05 -4.372861e-05
## ASV0755     -6.353015e-38 -3.894472e-04 -4.073588e-04 -4.258463e-04
## ASV0796      2.692328e-38  1.585093e-04  1.656820e-04  1.728670e-04
## ASV0878      5.441067e-38  3.375729e-04  3.533016e-04  3.695438e-04
## ASV4988     -3.372883e-38 -2.095773e-04 -2.193236e-04 -2.294220e-04
## ASV0083     -3.793139e-38 -2.393064e-04 -2.504600e-04 -2.621694e-04
## ASV0273      1.920534e-38  1.125401e-04  1.176782e-04  1.227633e-04
## ASV3076      1.240580e-38  7.870319e-05  8.242472e-05  8.630384e-05
## ASV1513      1.050208e-38  6.458104e-05  6.758700e-05  7.066383e-05
## ASV5159     -2.985012e-39 -1.624088e-05 -1.700274e-05 -1.767171e-05
## ASV3422     -2.540820e-38 -1.594330e-04 -1.669272e-04 -1.746972e-04
## ASV12230    -3.949073e-39 -2.278930e-05 -2.378149e-05 -2.478661e-05
## ASV1694      5.402647e-38  3.295663e-04  3.450061e-04  3.605946e-04
## ASV1249      2.316279e-38  1.443687e-04  1.513080e-04  1.583013e-04
## ASV1697     -1.306938e-38 -7.987341e-05 -8.354261e-05 -8.732182e-05
## ASV4408     -3.326927e-38 -1.956375e-04 -2.045538e-04 -2.134221e-04
## ASV0095     -3.882255e-38 -2.467145e-04 -2.584385e-04 -2.706264e-04
## ASV0410      5.776032e-40  7.492326e-07  7.988490e-07  6.887258e-07
## ASV4642     -4.938669e-38 -3.083709e-04 -3.228478e-04 -3.377948e-04
## ASV4560     -6.902655e-40 -1.285875e-06 -1.227690e-06 -1.127655e-06
## ASV7586     -2.315701e-38 -1.453020e-04 -1.521121e-04 -1.591888e-04
## ASV4144     -2.590330e-38 -1.634479e-04 -1.711942e-04 -1.792094e-04
## ASV0327     -2.868261e-38 -1.772832e-04 -1.854689e-04 -1.939592e-04
## ASV0946     -2.519712e-38 -1.495930e-04 -1.562495e-04 -1.630983e-04
## ASV3254     -3.040027e-38 -1.915048e-04 -2.005474e-04 -2.099193e-04
## ASV0349      4.421535e-38  2.765811e-04  2.895279e-04  3.029543e-04
## ASV0472     -2.726909e-38 -1.686451e-04 -1.764404e-04 -1.845216e-04
## ASV1330      2.820047e-38  1.697962e-04  1.775103e-04  1.854038e-04
## ASV2605      2.879268e-38  1.801422e-04  1.886077e-04  1.973548e-04
## ASV2846     -1.596366e-38 -1.028551e-04 -1.078198e-04 -1.129749e-04
## ASV3982     -1.316464e-38 -8.376402e-05 -8.776630e-05 -9.191283e-05
## ASV4116     -3.040027e-38 -1.915048e-04 -2.005206e-04 -2.098901e-04
## ASV6048     -1.771592e-38 -1.121393e-04 -1.174240e-04 -1.229382e-04
## ASV1146      3.722078e-38  2.311775e-04  2.419642e-04  2.530975e-04
## ASV13362     2.410474e-39  1.354106e-05  1.411190e-05  1.468593e-05
## ASV1422     -3.040027e-38 -1.915048e-04 -2.005008e-04 -2.098684e-04
## ASV3640     -3.040027e-38 -1.915048e-04 -2.004855e-04 -2.098518e-04
## ASV5404      2.487178e-38  1.501311e-04  1.569513e-04  1.639555e-04
## ASV6118     -3.040027e-38 -1.915048e-04 -2.004754e-04 -2.098406e-04
## ASV1115     -2.592496e-38 -1.633836e-04 -1.711208e-04 -1.791181e-04
## ASV0888     -5.620737e-38 -3.499158e-04 -3.662958e-04 -3.832004e-04
## ASV4620      9.189096e-39  4.593700e-05  4.765461e-05  4.928630e-05
## ASV3099      1.058778e-38  6.874081e-05  7.207765e-05  7.554987e-05
## ASV7099      4.881364e-39  3.195980e-05  3.349444e-05  3.511961e-05
## ASV5892     -3.530855e-38 -2.203287e-04 -2.306167e-04 -2.412852e-04
## ASV6978     -3.485570e-38 -2.193499e-04 -2.296534e-04 -2.403764e-04
## ASV6555     -1.067276e-38 -7.435287e-05 -7.807952e-05 -8.208802e-05
## ASV0539     -4.482517e-38 -2.765803e-04 -2.894454e-04 -3.026766e-04
## ASV4665      1.324299e-38  7.772118e-05  8.109831e-05  8.459836e-05
## ASV2210      2.825782e-38  1.667676e-04  1.742252e-04  1.818285e-04
## ASV1329      2.770622e-38  1.747183e-04  1.829891e-04  1.915458e-04
## ASV7123     -4.034530e-38 -2.536486e-04 -2.655947e-04 -2.779841e-04
## ASV1260      1.515010e-40  1.602765e-06  1.736959e-06  1.851800e-06
## ASV1011      4.056037e-38  2.587658e-04  2.711650e-04  2.840026e-04
## ASV4233      1.112053e-38  7.075386e-05  7.416436e-05  7.766654e-05
## ASV1475      4.274011e-38  2.634608e-04  2.757043e-04  2.883067e-04
## ASV6099     -4.940898e-38 -3.051499e-04 -3.192425e-04 -3.338461e-04
## ASV1428     -1.827989e-39  1.212189e-06  1.570192e-06  2.284201e-06
## ASV5101     -5.283484e-38 -3.343444e-04 -3.501364e-04 -3.665826e-04
## ASV11827    -2.412558e-38 -1.508786e-04 -1.579247e-04 -1.652479e-04
## ASV13899    -2.744962e-38 -1.715828e-04 -1.795753e-04 -1.878971e-04
## ASV21259    -3.208564e-38 -2.014207e-04 -2.108433e-04 -2.206607e-04
## ASV6635     -1.557054e-38 -9.955787e-05 -1.042202e-04 -1.091644e-04
## ASV9922     -4.307029e-38 -2.700159e-04 -2.826081e-04 -2.957450e-04
## ASV2869      5.465388e-39  3.326308e-05  3.476409e-05  3.632420e-05
## ASV1740      2.859320e-38  1.764195e-04  1.845273e-04  1.929586e-04
## ASV4406     -4.307029e-38 -2.719506e-04 -2.847638e-04 -2.981074e-04
## ASV5586     -3.647324e-38 -2.318716e-04 -2.428273e-04 -2.542855e-04
## ASV3255     -1.485802e-38 -9.211569e-05 -9.636501e-05 -1.007923e-04
## ASV12281    -2.116552e-38 -1.292840e-04 -1.352353e-04 -1.413533e-04
## ASV5388     -4.200144e-38 -2.550696e-04 -2.665704e-04 -2.785347e-04
## ASV17660    -4.183487e-38 -2.614306e-04 -2.737171e-04 -2.864016e-04
## ASV0159      2.400975e-38  1.438752e-04  1.507596e-04  1.574572e-04
## ASV2734     -6.251970e-38 -3.877501e-04 -4.058624e-04 -4.245194e-04
## ASV2049      4.712326e-39  2.943501e-05  3.087015e-05  3.230364e-05
## ASV2465      3.938409e-39  1.907255e-05  1.968556e-05  2.031965e-05
## ASV2147      2.099095e-38  1.210422e-04  1.262450e-04  1.315869e-04
## ASV3113     -6.098769e-39 -3.738119e-05 -3.912354e-05 -4.089480e-05
## ASV0622     -4.377638e-38 -2.747271e-04 -2.877075e-04 -3.010969e-04
## ASV0437     -4.440115e-38 -2.756528e-04 -2.885066e-04 -3.017793e-04
## ASV6385     -4.813332e-38 -3.013249e-04 -3.154880e-04 -3.301351e-04
## ASV3699     -4.307029e-38 -2.733004e-04 -2.862104e-04 -2.996905e-04
## ASV2208      4.307029e-38  2.733004e-04  2.861885e-04  2.996665e-04
## ASV1053      1.007388e-38  6.256372e-05  6.541281e-05  6.842454e-05
## ASV8468     -1.004395e-38 -6.131065e-05 -6.408141e-05 -6.697446e-05
## ASV0951     -3.714148e-38 -2.293420e-04 -2.402073e-04 -2.512004e-04
## ASV0278      5.376201e-38  3.284969e-04  3.435463e-04  3.590807e-04
## ASV0914     -2.767334e-38 -1.715913e-04 -1.796734e-04 -1.879289e-04
## ASV0737      4.307029e-38  2.566249e-04  2.685069e-04  2.803226e-04
## ASV2038      6.043088e-38  3.703824e-04  3.876006e-04  4.051915e-04
## ASV2171      3.803113e-38  2.253047e-04  2.356980e-04  2.460023e-04
## ASV2607      4.307029e-38  2.566248e-04  2.684603e-04  2.802737e-04
## ASV3143      3.311421e-38  1.949402e-04  2.038840e-04  2.127327e-04
## ASV3187     -4.610563e-38 -2.753502e-04 -2.880153e-04 -3.007228e-04
## ASV3810      4.307029e-38  2.566247e-04  2.684046e-04  2.802155e-04
## ASV5060     -2.692454e-38 -1.580480e-04 -1.652757e-04 -1.724264e-04
## ASV5325      4.307029e-38  2.566246e-04  2.683737e-04  2.801831e-04
## ASV6905     -4.307029e-38 -2.566245e-04 -2.683539e-04 -2.801623e-04
## ASV7597     -4.307029e-38 -2.566245e-04 -2.683341e-04 -2.801414e-04
## ASV9652     -4.307029e-38 -2.566244e-04 -2.683144e-04 -2.801205e-04
## ASV2634      4.307029e-38  2.566244e-04  2.682947e-04  2.800997e-04
## ASV3065      4.307029e-38  2.566243e-04  2.682750e-04  2.800788e-04
## ASV3331      4.307029e-38  2.566243e-04  2.682554e-04  2.800580e-04
## ASV7434     -4.307029e-38 -2.566242e-04 -2.682358e-04 -2.800371e-04
## ASV7720      5.262120e-39  4.061806e-05  4.279078e-05  4.516286e-05
## ASV8414     -4.307029e-38 -2.566241e-04 -2.682181e-04 -2.800183e-04
## ASV12139    -4.307029e-38 -2.566241e-04 -2.681985e-04 -2.799975e-04
## ASV1824      4.202166e-38  2.501149e-04  2.613643e-04  2.728484e-04
## ASV2094      4.253947e-38  2.534159e-04  2.648057e-04  2.764522e-04
## ASV2770     -8.408167e-39 -5.783772e-05 -6.073838e-05 -6.381598e-05
## ASV3505     -2.190723e-38 -1.243465e-04 -1.296736e-04 -1.350483e-04
## ASV1935      4.307029e-38  2.566239e-04  2.681353e-04  2.799299e-04
## ASV5764     -4.307029e-38 -2.566238e-04 -2.681159e-04 -2.799091e-04
## ASV6806      2.558184e-38  1.629887e-04  1.707455e-04  1.788156e-04
## ASV6942     -4.307029e-38 -2.566238e-04 -2.680979e-04 -2.798897e-04
## ASV1166      4.710626e-38  2.819594e-04  2.946021e-04  3.076267e-04
## ASV1664      3.290420e-38  2.000743e-04  2.092931e-04  2.187048e-04
## ASV2568      4.307029e-38  2.566237e-04  2.680606e-04  2.798495e-04
## ASV3525      4.307029e-38  2.566236e-04  2.680414e-04  2.798287e-04
## ASV4965     -5.043521e-38 -3.065292e-04 -3.205224e-04 -3.349348e-04
## ASV6607     -2.751995e-38 -1.591944e-04 -1.660156e-04 -1.730600e-04
## ASV7187      1.411339e-38  8.663972e-05  9.075806e-05  9.488278e-05
## ASV0388     -3.960348e-38 -2.526750e-04 -2.646906e-04 -2.772245e-04
## ASV1420      3.510812e-54  1.571938e-06  1.691733e-06  1.848604e-06
## ASV14293     1.257258e-38  8.194753e-05  8.587536e-05  9.002686e-05
## ASV17785     3.510812e-54  1.571939e-06  1.685477e-06  1.841612e-06
## ASV7678      3.797204e-39  1.642073e-05  1.695047e-05  1.736866e-05
## ASV2253      1.063109e-38  6.912819e-05  7.246707e-05  7.596185e-05
## ASV4150      2.316890e-38  1.396698e-04  1.460753e-04  1.525896e-04
## ASV3836     -5.193631e-38 -3.221550e-04 -3.371378e-04 -3.526384e-04
## ASV16231    -4.180607e-38 -2.638532e-04 -2.762759e-04 -2.892153e-04
## ASV2730      8.527633e-40  5.292177e-06  5.574844e-06  5.833435e-06
## ASV2072      2.542236e-38  1.508206e-04  1.574834e-04  1.643750e-04
## ASV2160      5.778867e-39  3.975964e-05  4.175870e-05  4.388312e-05
## ASV5013      8.554903e-39  4.936533e-05  5.156648e-05  5.374217e-05
## ASV2586      1.430819e-38  8.802629e-05  9.213416e-05  9.632767e-05
## ASV1442      1.097388e-38  6.892946e-05  7.218801e-05  7.554119e-05
## ASV3101      1.706056e-38  9.900269e-05  1.033397e-04  1.077368e-04
## ASV3323     -1.268229e-38 -8.179955e-05 -8.572360e-05 -8.978671e-05
## ASV1812      4.250432e-38  2.531091e-04  2.643193e-04  2.759337e-04
## ASV6120     -4.295281e-39 -2.955501e-05 -3.095996e-05 -3.253172e-05
## ASV2565      9.308136e-39  5.521255e-05  5.769090e-05  6.021663e-05
## ASV6687      4.647897e-39  2.823550e-05  2.959676e-05  3.092824e-05
## ASV5357     -3.544703e-38 -2.205527e-04 -2.307887e-04 -2.414284e-04
## ASV9383      1.822722e-38  1.099564e-04  1.149650e-04  1.200939e-04
## ASV11753    -3.040027e-38 -1.888235e-04 -1.975497e-04 -2.066403e-04
## ASV11512    -8.443889e-39 -5.244308e-05 -5.478460e-05 -5.730400e-05
## ASV2791     -1.001107e-39 -8.135342e-06 -8.525973e-06 -9.015298e-06
## ASV0664     -6.462177e-38 -3.993651e-04 -4.179315e-04 -4.370636e-04
## ASV3436      5.808385e-39  4.069525e-05  4.276957e-05  4.498399e-05
## ASV5755      4.420510e-38  2.720176e-04  2.846754e-04  2.976481e-04
## ASV10970    -4.307029e-38 -2.673211e-04 -2.797787e-04 -2.926449e-04
## ASV11798    -2.199585e-38 -1.364456e-04 -1.427585e-04 -1.493189e-04
## ASV18193    -4.307029e-38 -2.673211e-04 -2.797484e-04 -2.926120e-04
## ASV2548      4.604562e-38  2.816031e-04  2.945793e-04  3.079195e-04
## ASV3901      4.976453e-38  3.043360e-04  3.183977e-04  3.328187e-04
## ASV5197      1.984404e-39  6.046621e-06  6.059893e-06  6.028077e-06
## ASV5859      2.205638e-38  1.351086e-04  1.413163e-04  1.477291e-04
## ASV6240     -4.307029e-38 -2.673211e-04 -2.797364e-04 -2.925990e-04
## ASV7281      4.307029e-38  2.673211e-04  2.797154e-04  2.925761e-04
## ASV7635      2.394249e-38  1.499143e-04  1.570449e-04  1.643373e-04
## ASV8822     -4.307029e-38 -2.673211e-04 -2.796986e-04 -2.925578e-04
## ASV4810     -9.716380e-39 -5.718307e-05 -5.967421e-05 -6.225001e-05
## ASV5308      4.502545e-38  2.796865e-04  2.926489e-04  3.061183e-04
## ASV2749     -4.899388e-38 -3.059635e-04 -3.203243e-04 -3.351561e-04
## ASV0298      2.639139e-39  2.279277e-05  2.402761e-05  2.546266e-05
## ASV2597     -4.580768e-38 -2.868280e-04 -3.002843e-04 -3.142269e-04
## ASV5758     -1.920718e-38 -1.195607e-04 -1.251098e-04 -1.308836e-04
## ASV9987     -4.866217e-38 -3.032334e-04 -3.174747e-04 -3.321428e-04
## ASV0971      1.099668e-38  6.205989e-05  6.463759e-05  6.731508e-05
## ASV0627     -4.718140e-38 -2.958515e-04 -3.097660e-04 -3.241716e-04
## ASV1758      4.324426e-38  2.683308e-04  2.808738e-04  2.937922e-04
## ASV4559      3.105208e-41  1.040685e-06  1.142798e-06  1.236422e-06
## ASV11400    -2.171883e-39 -1.139180e-05 -1.181606e-05 -1.224791e-05
## ASV11559    -4.307029e-38 -2.696797e-04 -2.822674e-04 -2.953731e-04
## ASV3943     -4.307029e-38 -2.696797e-04 -2.822461e-04 -2.953498e-04
## ASV10389     8.575378e-39  5.071946e-05  5.301688e-05  5.532375e-05
## ASV5168      3.935741e-38  2.391267e-04  2.500863e-04  2.613262e-04
## ASV5724      2.652547e-38  1.663954e-04  1.742016e-04  1.823027e-04
## ASV6337      9.187161e-39  5.280600e-05  5.515180e-05  5.747095e-05
## ASV11063     2.537146e-38  1.515844e-04  1.583691e-04  1.653541e-04
## ASV4279     -4.630236e-39 -2.878385e-05 -3.012631e-05 -3.151450e-05
## ASV7660     -1.761531e-38 -1.115776e-04 -1.168582e-04 -1.223520e-04
## ASV8218     -1.761531e-38 -1.115776e-04 -1.168492e-04 -1.223422e-04
## ASV3574      6.944116e-38  4.378850e-04  4.585138e-04  4.799633e-04
## ASV12050    -1.761531e-38 -1.115776e-04 -1.168509e-04 -1.223441e-04
## ASV3897      1.656826e-38  1.002116e-04  1.047675e-04  1.094538e-04
## ASV3856     -5.419528e-38 -3.370846e-04 -3.527198e-04 -3.689691e-04
## ASV3024     -1.626094e-38 -1.060031e-04 -1.111534e-04 -1.165177e-04
## ASV8715     -4.213741e-38 -2.620844e-04 -2.743586e-04 -2.870088e-04
## ASV6917     -1.897001e-38 -1.110731e-04 -1.165698e-04 -1.215956e-04
## ASV1132      4.288932e-38  2.709730e-04  2.837071e-04  2.970075e-04
## ASV3583      2.137766e-38  1.361746e-04  1.426156e-04  1.493593e-04
## ASV0328      6.940724e-38  4.328533e-04  4.530647e-04  4.740162e-04
## ASV0915     -2.286033e-38 -1.449221e-04 -1.517378e-04 -1.588775e-04
## ASV2677      2.287369e-38  1.464084e-04  1.534013e-04  1.606870e-04
## ASV0599      2.437626e-38  1.484958e-04  1.555472e-04  1.625706e-04
## ASV0283     -6.365478e-38 -3.948659e-04 -4.132492e-04 -4.322484e-04
## ASV1028      2.574698e-38  1.631557e-04  1.708550e-04  1.788878e-04
## ASV0523      4.734915e-38  2.973444e-04  3.113586e-04  3.258603e-04
## ASV8201     -2.876728e-38 -1.812237e-04 -1.897037e-04 -1.985604e-04
## ASV2795     -9.235616e-39 -5.702945e-05 -5.961095e-05 -6.233767e-05
## ASV3563     -9.221702e-39 -5.694375e-05 -5.951687e-05 -6.223902e-05
## ASV1553     -1.754869e-38 -1.041521e-04 -1.088412e-04 -1.136111e-04
## ASV7155     -3.487376e-39 -2.817697e-05 -2.987657e-05 -3.156561e-05
## ASV0365      6.180454e-38  3.813607e-04  3.988929e-04  4.171273e-04
## ASV8583     -4.243646e-38 -2.619264e-04 -2.742137e-04 -2.867546e-04
## ASV5400      2.085204e-39  1.376740e-05  1.451267e-05  1.521995e-05
## ASV5908      3.356348e-38  2.031431e-04  2.123831e-04  2.218824e-04
## ASV2075      1.818949e-38  1.145834e-04  1.199031e-04  1.255022e-04
## ASV2520     -3.626775e-38 -2.283956e-04 -2.391601e-04 -2.503346e-04
## ASV9596     -1.877930e-38 -1.127992e-04 -1.179923e-04 -1.232304e-04
## ASV1131     -6.844056e-39 -3.793478e-05 -3.964728e-05 -4.124734e-05
## ASV0579     -1.208585e-38 -7.442018e-05 -7.792005e-05 -8.147643e-05
## ASV0288     -5.926669e-38 -3.643685e-04 -3.812712e-04 -3.986319e-04
## ASV4053      1.077875e-38  6.080044e-05  6.327282e-05  6.587280e-05
## ASV1736     -3.131613e-38 -1.944688e-04 -2.034869e-04 -2.128489e-04
## ASV1254      3.310807e-38  2.006146e-04  2.098590e-04  2.192681e-04
## ASV9038     -5.084157e-38 -3.180228e-04 -3.328625e-04 -3.482917e-04
## ASV4746      4.588977e-38  2.897996e-04  3.034826e-04  3.177054e-04
## ASV5803      1.761531e-38  1.100535e-04  1.151690e-04  1.205039e-04
## ASV0525      1.929316e-39  1.258201e-05  1.318450e-05  1.382279e-05
## ASV1974      2.791714e-38  1.682534e-04  1.759421e-04  1.837762e-04
## ASV1827      4.617373e-38  2.816133e-04  2.945775e-04  3.078740e-04
## ASV30780     2.561976e-39  1.396504e-05  1.457628e-05  1.514489e-05
## ASV9342      1.273144e-39  1.014228e-05  1.071326e-05  1.132423e-05
## ASV21626    -4.298399e-38 -2.658886e-04 -2.782786e-04 -2.910282e-04
## ASV1232     -3.066290e-38 -1.881926e-04 -1.969545e-04 -2.059084e-04
## ASV5578     -3.040027e-38 -1.898392e-04 -1.986837e-04 -2.078813e-04
## ASV5868      3.312771e-38  2.000335e-04  2.091247e-04  2.184663e-04
## ASV13625    -1.350441e-38 -8.275524e-05 -8.653603e-05 -9.045893e-05
## ASV3614      5.417200e-39  3.094305e-05  3.227311e-05  3.362155e-05
## ASV2128      2.723657e-38  1.713525e-04  1.794265e-04  1.877972e-04
## ASV5086      6.196260e-39  3.759036e-05  3.933144e-05  4.109395e-05
## ASV6614     -3.040027e-38 -1.898392e-04 -1.986755e-04 -2.078722e-04
## ASV9451     -3.040027e-38 -1.898392e-04 -1.986606e-04 -2.078559e-04
## ASV9533     -3.040027e-38 -1.898392e-04 -1.986457e-04 -2.078396e-04
## ASV10697    -9.830274e-53  2.142690e-06  2.322016e-06  2.539594e-06
## ASV1473     -1.496456e-38 -8.943462e-05 -9.343839e-05 -9.755951e-05
## ASV1414     -8.822413e-39 -5.618440e-05 -5.885656e-05 -6.162953e-05
## ASV1567     -8.185222e-39 -5.485370e-05 -5.749020e-05 -6.034675e-05
## ASV6395     -3.040027e-38 -1.912331e-04 -2.001939e-04 -2.095365e-04
## ASV2366      1.339779e-38  7.753935e-05  8.099022e-05  8.442544e-05
## ASV2537      1.318291e-38  7.725440e-05  8.071067e-05  8.419095e-05
## ASV5378     -3.040027e-38 -1.912332e-04 -2.001870e-04 -2.095286e-04
## ASV5929     -3.202008e-38 -2.012905e-04 -2.106992e-04 -2.205236e-04
## ASV6360      2.635489e-38  1.602062e-04  1.676351e-04  1.751704e-04
## ASV7916     -4.739203e-39 -3.220451e-05 -3.375684e-05 -3.545780e-05
## ASV13322     9.764211e-39  6.323345e-05  6.632212e-05  6.951105e-05
## ASV6207     -3.894442e-38 -2.421832e-04 -2.535072e-04 -2.651914e-04
## ASV8823     -3.083163e-38 -1.926707e-04 -2.016960e-04 -2.110404e-04
## ASV1379      4.307029e-38  2.682660e-04  2.807871e-04  2.937494e-04
## ASV3259     -4.307029e-38 -2.682660e-04 -2.807659e-04 -2.937264e-04
## ASV18748    -2.516290e-40  5.358788e-07  6.188262e-07  7.574088e-07
## ASV3570      9.265570e-39  5.821350e-05  6.099739e-05  6.384047e-05
## ASV0790     -1.112853e-38 -5.917191e-05 -6.149310e-05 -6.382420e-05
## ASV5149     -3.967337e-38 -2.452704e-04 -2.567303e-04 -2.684885e-04
## ASV1730     -4.079650e-38 -2.531622e-04 -2.649017e-04 -2.770802e-04
## ASV3488     -3.569086e-39 -2.091876e-05 -2.182091e-05 -2.276232e-05
## ASV5486     -4.307029e-38 -2.736626e-04 -2.865885e-04 -3.001064e-04
## ASV1319      8.796519e-39  4.441138e-05  4.613950e-05  4.775209e-05
## ASV15328    -3.040027e-38 -1.887361e-04 -1.975018e-04 -2.065888e-04
## ASV5994      4.376886e-38  2.724649e-04  2.851265e-04  2.982794e-04
## ASV4992     -3.727257e-39 -2.199804e-05 -2.298550e-05 -2.398390e-05
## ASV1788     -4.942839e-38 -2.988260e-04 -3.123858e-04 -3.263515e-04
## ASV3264     -1.094285e-39 -3.826389e-06 -3.871103e-06 -3.894058e-06
## ASV4895      2.304876e-39  1.296494e-05  1.352914e-05  1.408196e-05
## ASV9218     -1.341633e-39 -5.197697e-06 -5.277566e-06 -5.356211e-06
## ASV0736     -3.896382e-40 -5.372918e-06 -5.755406e-06 -6.173760e-06
## ASV0916      3.040027e-38  1.887360e-04  1.974657e-04  2.065496e-04
## ASV15761    -3.040027e-38 -1.887360e-04 -1.974509e-04 -2.065335e-04
## ASV4191      3.856746e-38  2.356273e-04  2.464337e-04  2.575757e-04
## ASV3268     -8.218848e-39 -4.852314e-05 -5.070820e-05 -5.291050e-05
## ASV15321    -4.457664e-39 -3.042370e-05 -3.191186e-05 -3.352344e-05
## ASV0708     -2.983608e-38 -1.881266e-04 -1.969934e-04 -2.062095e-04
## ASV4100      4.016963e-39  2.248101e-05  2.350198e-05  2.445891e-05
## ASV1627      2.603563e-38  1.526413e-04  1.593978e-04  1.662919e-04
## ASV7045     -2.671559e-38 -1.667436e-04 -1.746196e-04 -1.826950e-04
## ASV3271      7.978757e-39  4.109493e-05  4.264479e-05  4.420384e-05
## ASV6200     -4.478342e-39 -2.890118e-05 -3.029555e-05 -3.175110e-05
## ASV2727     -3.060995e-38 -1.962402e-04 -2.056570e-04 -2.154359e-04
## ASV3523     -4.219612e-38 -2.609672e-04 -2.731953e-04 -2.857142e-04
## ASV2259      2.832814e-38  1.760919e-04  1.842892e-04  1.927814e-04
## ASV0181      4.209740e-38  2.590859e-04  2.710705e-04  2.834265e-04
## ASV1680      8.363405e-38  5.184930e-04  5.426521e-04  5.675797e-04
## ASV0176      8.920378e-39  5.302650e-05  5.543215e-05  5.785994e-05
## ASV10458    -3.040027e-38 -1.893357e-04 -1.981811e-04 -2.073317e-04
## ASV10658    -3.040027e-38 -1.893357e-04 -1.981661e-04 -2.073155e-04
## ASV16807    -3.040027e-38 -1.893357e-04 -1.981512e-04 -2.072992e-04
## ASV2113     -3.040027e-38 -1.893357e-04 -1.981362e-04 -2.072830e-04
## ASV2403      3.158448e-38  1.944613e-04  2.034296e-04  2.127019e-04
## ASV2484     -3.040027e-38 -1.893357e-04 -1.981301e-04 -2.072763e-04
## ASV8876     -3.040027e-38 -1.893357e-04 -1.981152e-04 -2.072600e-04
## ASV0386      4.388575e-38  2.765242e-04  2.894985e-04  3.030290e-04
## ASV0351      1.266892e-38  7.673294e-05  8.016972e-05  8.375475e-05
## ASV4942     -1.743414e-38 -1.080154e-04 -1.129479e-04 -1.181334e-04
## ASV5128     -1.323837e-38 -8.351455e-05 -8.738527e-05 -9.146967e-05
## ASV3496      1.425058e-38  9.317875e-05  9.774039e-05  1.024865e-04
## ASV3329      4.379282e-38  2.752929e-04  2.882441e-04  3.016823e-04
## ASV7878     -3.040027e-38 -1.887802e-04 -1.975017e-04 -2.065870e-04
## ASV8251     -1.154975e-38 -7.172883e-05 -7.503126e-05 -7.848119e-05
## ASV15958    -9.834646e-39 -6.191819e-05 -6.476432e-05 -6.778501e-05
## ASV7972     -4.307029e-38 -2.695357e-04 -2.821526e-04 -2.952441e-04
## ASV2088      4.307029e-38  2.695357e-04  2.821312e-04  2.952209e-04
## ASV3054     -2.025664e-38 -1.268731e-04 -1.327936e-04 -1.389577e-04
## ASV4494     -4.307029e-38 -2.695356e-04 -2.821014e-04 -2.951884e-04
## ASV0087     -8.251085e-38 -5.114485e-04 -5.351609e-04 -5.597362e-04
## ASV1614     -3.377745e-38 -2.090453e-04 -2.188218e-04 -2.288547e-04
## ASV3037     -1.860880e-38 -1.156838e-04 -1.211680e-04 -1.267522e-04
## ASV6615     -4.386457e-39 -3.000699e-05 -3.150718e-05 -3.309968e-05
## ASV1027      1.283109e-38  7.861818e-05  8.221562e-05  8.594156e-05
## ASV2754     -7.320234e-39 -4.861193e-05 -5.095812e-05 -5.346544e-05
## ASV0536     -5.846963e-39 -3.803016e-05 -3.986596e-05 -4.178872e-05
## ASV2318     -1.270832e-38 -8.081064e-05 -8.461129e-05 -8.860534e-05
## ASV5954      2.687102e-38  1.615541e-04  1.688707e-04  1.763737e-04
## ASV9028      1.812002e-38  1.131930e-04  1.184980e-04  1.239845e-04
## ASV6600     -3.040027e-38 -1.913244e-04 -2.002746e-04 -2.096233e-04
## ASV1923     -8.299008e-39 -5.060743e-05 -5.289302e-05 -5.527586e-05
## ASV4034     -5.193104e-39 -3.659515e-05 -3.837241e-05 -4.036075e-05
## ASV9933     -3.040027e-38 -1.913244e-04 -2.002536e-04 -2.096002e-04
## ASV1575      6.183101e-39  3.617776e-05  3.777376e-05  3.940393e-05
## ASV7812     -5.242834e-38 -3.255313e-04 -3.407992e-04 -3.564817e-04
## ASV0515      3.451993e-38  2.102899e-04  2.198116e-04  2.297123e-04
## ASV1149     -2.771597e-39 -2.305398e-05 -2.433826e-05 -2.575517e-05
## ASV3791      1.368968e-38  8.737430e-05  9.144770e-05  9.577789e-05
## ASV4065     -4.893616e-38 -3.045635e-04 -3.186988e-04 -3.333920e-04
## ASV10631    -2.299719e-39 -1.694528e-05 -1.778915e-05 -1.874780e-05
## ASV2359     -5.026041e-38 -3.022999e-04 -3.159939e-04 -3.300455e-04
## ASV3206     -3.040027e-38 -1.894545e-04 -1.983158e-04 -2.074803e-04
## ASV4415      2.472808e-38  1.542281e-04  1.614286e-04  1.688886e-04
## ASV4467     -2.202237e-38 -1.359572e-04 -1.422701e-04 -1.487774e-04
## ASV5598      3.638726e-38  2.316995e-04  2.426944e-04  2.541673e-04
## ASV5910     -3.348159e-38 -2.089999e-04 -2.187602e-04 -2.288859e-04
## ASV9494     -3.040027e-38 -1.894545e-04 -1.982750e-04 -2.074360e-04
## ASV6548     -2.491846e-38 -1.547976e-04 -1.619703e-04 -1.694279e-04
## ASV8669     -3.040027e-38 -1.894545e-04 -1.982481e-04 -2.074067e-04
## ASV0674      1.962709e-38  1.182687e-04  1.236345e-04  1.291353e-04
## ASV0061     -7.184781e-39 -5.551956e-05 -5.845965e-05 -6.169586e-05
## ASV0310     -1.948525e-38 -1.177283e-04 -1.229651e-04 -1.284775e-04
## ASV0582      6.454997e-39  3.657020e-05  3.815041e-05  3.973084e-05
## ASV0739      5.695466e-38  3.584909e-04  3.753339e-04  3.928513e-04
## ASV1557      2.335143e-38  1.493822e-04  1.565115e-04  1.639436e-04
## ASV0146      5.568066e-38  3.363176e-04  3.517397e-04  3.674502e-04
## ASV3832      5.599303e-38  3.429288e-04  3.587704e-04  3.750328e-04
## ASV0734      1.204715e-38  7.634825e-05  8.001990e-05  8.377865e-05
## ASV3036     -3.978679e-38 -2.504909e-04 -2.623008e-04 -2.745547e-04
## ASV0240      1.104614e-38  6.756115e-05  7.068404e-05  7.388423e-05
## ASV2513     -6.119988e-38 -3.768651e-04 -3.944353e-04 -4.124281e-04
## ASV1118     -1.556208e-38 -9.982888e-05 -1.046814e-04 -1.096613e-04
## ASV7286     -3.040027e-38 -1.889275e-04 -1.977866e-04 -2.068996e-04
## ASV1077      4.127605e-38  2.528604e-04  2.645439e-04  2.765451e-04
## ASV1255     -3.040027e-38 -1.889274e-04 -1.977543e-04 -2.068648e-04
## ASV1794     -1.742954e-39 -1.142341e-05 -1.193942e-05 -1.251656e-05
## ASV2439     -3.040027e-38 -1.889274e-04 -1.977400e-04 -2.068493e-04
## ASV2467     -3.040027e-38 -1.889274e-04 -1.977251e-04 -2.068331e-04
## ASV3346     -3.040027e-38 -1.889274e-04 -1.977102e-04 -2.068170e-04
## ASV3973     -3.040027e-38 -1.889274e-04 -1.976954e-04 -2.068008e-04
## ASV4521      1.367489e-38  8.362637e-05  8.748065e-05  9.143482e-05
## ASV1909     -3.534639e-38 -2.240269e-04 -2.346255e-04 -2.456600e-04
## ASV3855     -2.745899e-38 -1.695082e-04 -1.773081e-04 -1.854133e-04
## ASV0810      3.612395e-38  2.257866e-04  2.363437e-04  2.472942e-04
## ASV1765      4.274591e-38  2.690489e-04  2.816640e-04  2.948134e-04
## ASV0763      2.361034e-38  1.465670e-04  1.533222e-04  1.603741e-04
## ASV0302     -2.606538e-38 -1.600310e-04 -1.673558e-04 -1.749588e-04
## ASV2643     -3.633385e-38 -2.182928e-04 -2.283087e-04 -2.384619e-04
## ASV0440      1.322707e-38  8.422834e-05  8.815537e-05  9.230920e-05
## ASV4899     -2.544501e-38 -1.536627e-04 -1.606494e-04 -1.678162e-04
## ASV0287     -1.478757e-38 -9.292120e-05 -9.725620e-05 -1.017919e-04
## ASV3220      1.836803e-38  1.161241e-04  1.216499e-04  1.273510e-04
## ASV1007     -1.121338e-38 -6.728679e-05 -7.028801e-05 -7.339891e-05
## ASV2929     -7.419660e-39 -4.311374e-05 -4.497698e-05 -4.689418e-05
## ASV1496     -2.526874e-38 -1.600943e-04 -1.675796e-04 -1.754554e-04
## ASV4975      1.115656e-38  7.003101e-05  7.330521e-05  7.671261e-05
## ASV4392     -2.125475e-39 -1.000587e-05 -1.045338e-05 -1.076795e-05
## ASV4653     -3.040027e-38 -1.908378e-04 -1.997428e-04 -2.090413e-04
## ASV0230     -1.538055e-38 -9.753220e-05 -1.021734e-04 -1.069805e-04
## ASV0840      2.197581e-38  1.377267e-04  1.441258e-04  1.508233e-04
## ASV4132     -6.325908e-39 -4.100634e-05 -4.293526e-05 -4.499975e-05
## ASV3344      2.357074e-38  1.439519e-04  1.505178e-04  1.573191e-04
## ASV12096    -3.070205e-38 -1.933406e-04 -2.025245e-04 -2.119806e-04
## ASV1550      1.126883e-38  6.518792e-05  6.805987e-05  7.094823e-05
## ASV3542     -4.516231e-38 -2.865426e-04 -3.001232e-04 -3.142356e-04
## ASV8795     -1.761531e-38 -1.110229e-04 -1.162286e-04 -1.216610e-04
## ASV2532     -7.746705e-40 -5.875546e-06 -6.179098e-06 -6.519181e-06
## ASV3087      7.689922e-39  4.620340e-05  4.831318e-05  5.045706e-05
## ASV9476     -1.761531e-38 -1.110229e-04 -1.162225e-04 -1.216543e-04
## ASV13721    -1.761531e-38 -1.110229e-04 -1.162137e-04 -1.216446e-04
## ASV3842      3.012661e-38  1.834955e-04  1.919608e-04  2.006115e-04
## ASV1663      5.419548e-38  3.303744e-04  3.454982e-04  3.610814e-04
## ASV0432      1.275744e-38  7.761027e-05  8.122731e-05  8.488460e-05
## ASV4356      5.254926e-38  3.261442e-04  3.413207e-04  3.570195e-04
## ASV4524      1.227914e-38  7.898520e-05  8.277556e-05  8.672685e-05
## ASV0169     -2.531687e-38 -1.605636e-04 -1.682030e-04 -1.761170e-04
## ASV0368     -2.177830e-38 -1.380267e-04 -1.445869e-04 -1.513839e-04
## ASV2603     -3.159731e-53  4.204211e-08  6.910920e-08  7.149094e-08
## ASV3777      2.922679e-38  1.824661e-04  1.909655e-04  1.998014e-04
## ASV3978      2.569218e-38  1.586095e-04  1.659648e-04  1.735499e-04
## ASV0413     -2.056321e-38 -1.302726e-04 -1.364414e-04 -1.428516e-04
## ASV0997      2.545339e-53 -4.203807e-08 -4.481703e-08 -4.514101e-08
## ASV1195      2.545339e-53 -4.203875e-08 -4.481233e-08 -4.514043e-08
## ASV2522     -1.383160e-38 -8.592150e-05 -8.992256e-05 -9.406205e-05
## ASV4733      2.505383e-38  1.568063e-04  1.641391e-04  1.717519e-04
## ASV1063      4.307029e-38  2.743104e-04  2.873538e-04  3.009411e-04
## ASV0612     -5.552434e-38 -3.502166e-04 -3.666972e-04 -3.838619e-04
## ASV1903     -4.307029e-38 -2.743104e-04 -2.873057e-04 -3.008885e-04
## ASV3576     -1.197723e-38 -7.951576e-05 -8.341458e-05 -8.752376e-05
## ASV4285     -3.095438e-38 -1.955813e-04 -2.048959e-04 -2.144997e-04
## ASV3406     -1.626288e-38 -1.018944e-04 -1.066345e-04 -1.115894e-04
## ASV2379     -3.192772e-38 -1.902829e-04 -1.989844e-04 -2.077427e-04
## ASV0528      3.816776e-38  2.392023e-04  2.504446e-04  2.620815e-04
## ASV6190     -4.716481e-39 -3.097497e-05 -3.242179e-05 -3.399961e-05
## ASV1537     -6.867209e-40 -2.662551e-06 -2.751168e-06 -2.792222e-06
## ASV16780    -3.435590e-38 -2.129777e-04 -2.229593e-04 -2.332043e-04
## ASV0477      8.478532e-38  5.287614e-04  5.534110e-04  5.789935e-04
## ASV1499      1.818570e-38  1.203455e-04  1.261418e-04  1.323253e-04
## ASV14736     1.488083e-38  9.183241e-05  9.611140e-05  1.005077e-04
## ASV0179     -1.208851e-38 -7.620096e-05 -7.975793e-05 -8.348480e-05
## ASV3153      2.739063e-40  6.048219e-06  6.366185e-06  6.883729e-06
## ASV0266      3.932887e-38  2.468574e-04  2.584722e-04  2.705097e-04
## ASV0761      5.930933e-38  3.661430e-04  3.832390e-04  4.007695e-04
## ASV0269     -5.082833e-39 -3.553890e-05 -3.726639e-05 -3.918982e-05
## ASV7259     -1.025253e-38 -6.873749e-05 -7.215260e-05 -7.572973e-05
## ASV2067     -1.283911e-38 -7.773780e-05 -8.132201e-05 -8.496447e-05
## ASV2985     -3.473450e-38 -2.169699e-04 -2.271261e-04 -2.376335e-04
## ASV0975     -5.235299e-38 -3.287436e-04 -3.441549e-04 -3.601812e-04
## ASV2240      3.222151e-38  1.962929e-04  2.052263e-04  2.144798e-04
## ASV2297      1.107632e-38  6.416032e-05  6.701539e-05  6.986726e-05
## ASV2657      1.373581e-38  8.274745e-05  8.641838e-05  9.026708e-05
## ASV3784      5.617299e-53  2.681556e-06  2.841049e-06  3.107771e-06
## ASV4333      6.319462e-53  2.681555e-06  2.840779e-06  3.107297e-06
## ASV5547      2.851122e-38  1.699012e-04  1.774719e-04  1.852833e-04
## ASV5813      1.148755e-38  6.884235e-05  7.199135e-05  7.517813e-05
## ASV8049      1.342177e-38  8.228931e-05  8.613203e-05  9.004503e-05
## ASV8661     -6.319462e-53 -2.681547e-06 -2.849259e-06 -3.116111e-06
## ASV9510      1.574031e-38  9.621344e-05  1.006788e-04  1.052337e-04
## ASV1401      8.339445e-39  5.054721e-05  5.288269e-05  5.525579e-05
## ASV1417     -1.757340e-38 -1.016218e-04 -1.060072e-04 -1.105069e-04
## ASV2169      5.646140e-38  3.506219e-04  3.668805e-04  3.837656e-04
## ASV5354     -5.617299e-53 -2.681521e-06 -2.859562e-06 -3.127051e-06
## ASV5379     -6.056151e-53 -2.681520e-06 -2.859261e-06 -3.126576e-06
## ASV6078     -6.319462e-53 -2.681519e-06 -2.858960e-06 -3.126101e-06
## ASV6417      3.497862e-38  2.145508e-04  2.244963e-04  2.346929e-04
## ASV8304      2.578021e-38  1.558447e-04  1.629020e-04  1.701831e-04
## ASV8766     -5.617299e-53 -2.681528e-06 -2.876631e-06 -3.145002e-06
## ASV10861     1.088676e-38  6.511431e-05  6.809094e-05  7.109751e-05
## ASV2057      5.574988e-38  3.466268e-04  3.627652e-04  3.794810e-04
## ASV4499      2.060167e-38  1.222621e-04  1.277211e-04  1.333089e-04
## ASV7415      6.084608e-39  3.840131e-05  4.018584e-05  4.206144e-05
## ASV2475     -2.377376e-38 -1.485477e-04 -1.554706e-04 -1.626740e-04
## ASV3517     -3.830651e-38 -2.426190e-04 -2.541041e-04 -2.660502e-04
## ASV1864      2.671838e-38  1.634467e-04  1.709256e-04  1.786618e-04
## ASV2756      3.040027e-38  1.883586e-04  1.971904e-04  2.062460e-04
## ASV0778      3.040027e-38  1.883586e-04  1.971754e-04  2.062300e-04
## ASV3201      6.133857e-39  4.251226e-05  4.462056e-05  4.690409e-05
## ASV3358      3.040027e-38  1.883586e-04  1.971627e-04  2.062163e-04
## ASV5681     -3.040027e-38 -1.883586e-04 -1.971478e-04 -2.062002e-04
## ASV7256      1.456183e-38  9.122436e-05  9.542678e-05  9.986754e-05
## ASV1704     -3.126444e-38 -1.927072e-04 -2.016546e-04 -2.108569e-04
## ASV4445      5.066048e-38  3.041588e-04  3.178662e-04  3.319707e-04
## ASV8649     -3.040027e-38 -1.883585e-04 -1.971172e-04 -2.061673e-04
## ASV0597      3.161529e-38  1.958003e-04  2.048849e-04  2.142866e-04
## ASV0861      4.058681e-38  2.494954e-04  2.610095e-04  2.728904e-04
## ASV2423      4.903294e-38  3.025311e-04  3.165617e-04  3.310244e-04
## ASV1548      2.491950e-38  1.481810e-04  1.547863e-04  1.615726e-04
## ASV2564      4.121197e-38  2.521173e-04  2.636382e-04  2.755653e-04
## ASV2999      6.880709e-38  4.194366e-04  4.386481e-04  4.584310e-04
## ASV4543     -2.380519e-38 -1.506816e-04 -1.577962e-04 -1.652112e-04
## ASV8452      2.390541e-38  1.441865e-04  1.507003e-04  1.574146e-04
## ASV17287    -4.316807e-39 -2.982243e-05 -3.136348e-05 -3.296875e-05
## ASV3503     -3.040027e-38 -1.927941e-04 -2.019007e-04 -2.114054e-04
## ASV4727     -4.615837e-39 -3.273881e-05 -3.442745e-05 -3.622600e-05
## ASV5995     -2.590448e-38 -1.640652e-04 -1.717925e-04 -1.798681e-04
## ASV1665     -8.303436e-39 -5.261825e-05 -5.501886e-05 -5.760279e-05
## ASV2690     -3.943560e-38 -2.458772e-04 -2.573936e-04 -2.692929e-04
## ASV2823     -3.362732e-39 -2.013372e-05 -2.099439e-05 -2.192217e-05
## ASV5241     -5.271523e-38 -3.287219e-04 -3.441766e-04 -3.600854e-04
## ASV5473     -1.473488e-38 -9.420544e-05 -9.870138e-05 -1.033873e-04
## ASV2785      6.525124e-39  4.245505e-05  4.450373e-05  4.665149e-05
## ASV6645     -2.246124e-38 -1.389753e-04 -1.455140e-04 -1.521846e-04
## ASV0562      9.603473e-39  5.658020e-05  5.906063e-05  6.161178e-05
## ASV1163      8.953873e-39  5.670655e-05  5.937215e-05  6.215939e-05
## ASV1825      1.754274e-38  1.073738e-04  1.123263e-04  1.174105e-04
## ASV3795      3.835534e-38  2.369376e-04  2.478590e-04  2.592033e-04
## ASV3869     -8.068118e-39 -5.284172e-05 -5.536171e-05 -5.805357e-05
## ASV4330      2.938276e-38  1.825280e-04  1.910090e-04  1.998000e-04
## ASV6754      1.117095e-38  6.937410e-05  7.261327e-05  7.595290e-05
## ASV4598     -1.263892e-52 -1.673084e-06 -1.792657e-06 -1.964419e-06
## ASV2100      2.317000e-38  1.405966e-04  1.469536e-04  1.535480e-04
## ASV3518      1.152372e-38  6.986669e-05  7.305609e-05  7.632675e-05
## ASV3823      4.697848e-38  2.889604e-04  3.022847e-04  3.160522e-04
## ASV7357      2.864235e-38  1.772832e-04  1.854563e-04  1.939584e-04
## ASV7403     -3.675345e-38 -2.265246e-04 -2.370863e-04 -2.479105e-04
## ASV2934     -1.795432e-39 -9.825731e-06 -1.024419e-05 -1.064685e-05
## ASV5277     -1.913656e-38 -1.178885e-04 -1.234265e-04 -1.290577e-04
## ASV0281     -5.619807e-38 -3.473925e-04 -3.635454e-04 -3.801993e-04
## ASV11181    -2.001933e-38 -1.286404e-04 -1.347825e-04 -1.412177e-04
## ASV0254     -8.439049e-39 -4.575259e-05 -4.769365e-05 -4.954325e-05
## ASV0201     -9.079864e-39 -5.970264e-05 -6.255079e-05 -6.560398e-05
## ASV3656     -2.285292e-38 -1.482619e-04 -1.553453e-04 -1.628276e-04
## ASV7994     -4.302881e-38 -2.682037e-04 -2.807384e-04 -2.937117e-04
## ASV3584     -1.530725e-38 -8.771091e-05 -9.169881e-05 -9.555708e-05
## ASV2157      4.525094e-38  2.764732e-04  2.890633e-04  3.021358e-04
## ASV2935     -5.673941e-39 -3.546228e-05 -3.713342e-05 -3.885551e-05
## ASV9024     -4.094669e-38 -2.515052e-04 -2.632121e-04 -2.751843e-04
## ASV7711      2.358290e-38  1.500354e-04  1.571505e-04  1.645713e-04
## ASV11330    -3.040027e-38 -1.903760e-04 -1.992445e-04 -2.084969e-04
## ASV1875      2.698005e-38  1.678230e-04  1.756431e-04  1.837458e-04
## ASV5861      1.969454e-38  1.254338e-04  1.313962e-04  1.376058e-04
## ASV11562     1.682179e-39  1.091079e-05  1.149189e-05  1.204504e-05
## ASV18559    -3.040027e-38 -1.903760e-04 -1.992397e-04 -2.084915e-04
## ASV4384      2.894791e-38  1.839432e-04  1.926601e-04  2.017450e-04
## ASV1302      6.249360e-38  3.774185e-04  3.944913e-04  4.121201e-04
## ASV4673     -3.963832e-38 -2.497934e-04 -2.615870e-04 -2.738128e-04
## ASV1956      7.443625e-39  4.250821e-05  4.414550e-05  4.600040e-05
## ASV3286      2.736242e-38  1.740384e-04  1.822949e-04  1.908981e-04
## ASV4866     -4.307029e-38 -2.730910e-04 -2.859896e-04 -2.994501e-04
## ASV3129     -2.128138e-38 -1.341073e-04 -1.404031e-04 -1.469693e-04
## ASV4104      4.966319e-38  3.087393e-04  3.231119e-04  3.379973e-04
## ASV8983      4.184759e-40  2.627695e-06  2.636635e-06  2.759437e-06
## ASV2201      1.971777e-38  1.185703e-04  1.239151e-04  1.294181e-04
## ASV3055      1.396143e-38  8.143057e-05  8.501051e-05  8.865840e-05
## ASV0534     -6.525738e-38 -4.027769e-04 -4.213758e-04 -4.406330e-04
## ASV1019      1.676070e-39  1.316611e-05  1.389055e-05  1.467442e-05
## ASV18482    -3.040027e-38 -1.873584e-04 -1.960428e-04 -2.049911e-04
## ASV2694      1.076664e-38  6.297351e-05  6.567858e-05  6.850343e-05
## ASV3412     -9.750170e-39 -5.785566e-05 -6.046107e-05 -6.310247e-05
## ASV4174     -3.040027e-38 -1.873584e-04 -1.960244e-04 -2.049713e-04
## ASV4281     -3.040027e-38 -1.873584e-04 -1.960097e-04 -2.049555e-04
## ASV4949      3.461644e-38  2.105806e-04  2.201724e-04  2.300809e-04
## ASV5881      1.609510e-38  9.887132e-05  1.033845e-04  1.080832e-04
## ASV6299     -1.377015e-38 -8.329750e-05 -8.706562e-05 -9.095657e-05
## ASV0676      3.515408e-38  2.153146e-04  2.251425e-04  2.353515e-04
## ASV1066     -2.409096e-38 -1.468997e-04 -1.536397e-04 -1.605681e-04
## ASV1300     -2.045763e-38 -1.255311e-04 -1.313396e-04 -1.373043e-04
## ASV6455      9.817844e-39  6.113570e-05  6.400646e-05  6.696206e-05
## ASV3455     -3.040027e-38 -1.873584e-04 -1.960054e-04 -2.049507e-04
## ASV6531     -3.040027e-38 -1.873584e-04 -1.959907e-04 -2.049349e-04
## ASV0490      6.166980e-38  3.748416e-04  3.922913e-04  4.099512e-04
## ASV2588      2.239553e-39  1.979382e-05  2.084299e-05  2.210037e-05
## ASV5364      1.922499e-38  1.180640e-04  1.234776e-04  1.290881e-04
## ASV0981     -4.146777e-38 -2.610009e-04 -2.732745e-04 -2.860322e-04
## ASV1563     -8.506239e-39 -5.358210e-05 -5.610453e-05 -5.872911e-05
## ASV0376     -3.978714e-38 -2.504242e-04 -2.622005e-04 -2.744382e-04
## ASV7308     -7.021624e-53 -1.192073e-06 -1.312174e-06 -1.440031e-06
## ASV4817      7.003246e-39  4.058565e-05  4.232463e-05  4.411955e-05
## ASV8716     -4.519475e-38 -2.667619e-04 -2.790389e-04 -2.911944e-04
## ASV1849      5.671268e-38  3.400970e-04  3.553524e-04  3.710876e-04
## ASV9423     -4.263563e-38 -2.618940e-04 -2.741271e-04 -2.866018e-04
## ASV7690      1.464947e-39  9.742676e-06  1.027286e-05  1.077780e-05
## ASV4901      2.303209e-38  1.444036e-04  1.511733e-04  1.582000e-04
## ASV1830     -6.285775e-39 -4.546274e-05 -4.777712e-05 -5.030776e-05
## ASV2316     -3.307379e-38 -1.953075e-04 -2.044091e-04 -2.133314e-04
## ASV0693      4.634568e-38  2.895710e-04  3.030600e-04  3.170948e-04
## ASV1243     -3.231771e-39 -1.625516e-05 -1.702574e-05 -1.761577e-05
## ASV3867      1.200127e-38  7.608015e-05  7.971183e-05  8.346067e-05
## ASV7932      2.631194e-38  1.641844e-04  1.718427e-04  1.797876e-04
## ASV12608     1.835579e-38  1.182940e-04  1.239700e-04  1.299011e-04
## ASV1661      2.779380e-38  1.720062e-04  1.800455e-04  1.883001e-04
## ASV3957      2.882247e-38  1.807181e-04  1.891418e-04  1.979384e-04
## ASV0830     -4.619947e-38 -2.854054e-04 -2.985874e-04 -3.122533e-04
## ASV2078      5.209910e-38  3.238818e-04  3.389656e-04  3.545904e-04
## ASV13932    -3.040027e-38 -1.908956e-04 -1.998331e-04 -2.091406e-04
## ASV5300     -3.040027e-38 -1.908956e-04 -1.998180e-04 -2.091241e-04
## ASV1014     -1.663817e-38 -1.027899e-04 -1.075432e-04 -1.124611e-04
## ASV13059    -8.628727e-39 -5.855153e-05 -6.152166e-05 -6.460745e-05
## ASV4340      6.468906e-39  3.905374e-05  4.075089e-05  4.257039e-05
## ASV5591     -5.155192e-38 -3.181510e-04 -3.330152e-04 -3.482410e-04
## ASV6040     -4.104540e-38 -2.542931e-04 -2.661674e-04 -2.783855e-04
## ASV3904     -1.654864e-38 -1.050748e-04 -1.100335e-04 -1.152175e-04
## ASV2267     -4.739763e-39 -2.972712e-05 -3.109801e-05 -3.254094e-05
## ASV0573     -3.943174e-38 -2.386682e-04 -2.494689e-04 -2.606319e-04
## ASV0851     -4.140501e-38 -2.567189e-04 -2.685510e-04 -2.808799e-04
## ASV7805      1.250375e-38  8.007852e-05  8.388224e-05  8.786956e-05
## ASV3379      5.637508e-38  3.439529e-04  3.596006e-04  3.758394e-04
## ASV0825      2.421932e-38  1.548923e-04  1.623065e-04  1.700071e-04
## ASV2461      2.925304e-38  1.798515e-04  1.881066e-04  1.966712e-04
## ASV2783      4.049980e-38  2.507395e-04  2.624341e-04  2.744731e-04
## ASV0925      4.601356e-38  2.813424e-04  2.942269e-04  3.075364e-04
## ASV7023     -4.265189e-38 -2.673558e-04 -2.799002e-04 -2.929111e-04
## ASV5319      7.620300e-39  4.853832e-05  5.083472e-05  5.323111e-05
## ASV3213      2.656255e-38  1.668734e-04  1.746892e-04  1.828243e-04
## ASV3748     -6.185416e-39 -4.119452e-05 -4.325325e-05 -4.539423e-05
## ASV5491     -9.286837e-39 -6.057396e-05 -6.352451e-05 -6.660451e-05
## ASV7931      1.679205e-38  1.051736e-04  1.100627e-04  1.151692e-04
## ASV12767    -3.040027e-38 -1.916526e-04 -2.006726e-04 -2.100598e-04
## ASV6389      3.072072e-38  1.931572e-04  2.022568e-04  2.116910e-04
## ASV14867    -3.040027e-38 -1.916526e-04 -2.006571e-04 -2.100429e-04
## ASV5105      1.745172e-38  1.114350e-04  1.167591e-04  1.222906e-04
## ASV15927    -3.040027e-38 -1.910954e-04 -2.000476e-04 -2.093741e-04
## ASV2004      1.066040e-38  6.579782e-05  6.879071e-05  7.193700e-05
## ASV5554      6.498068e-40 -2.894872e-06 -3.293912e-06 -3.800176e-06
## ASV10929    -2.126941e-38 -1.337494e-04 -1.399882e-04 -1.465187e-04
## ASV12778    -1.055950e-38 -6.603871e-05 -6.909643e-05 -7.230028e-05
## ASV14006    -3.040027e-38 -1.910954e-04 -2.000139e-04 -2.093370e-04
## ASV1603      2.961751e-38  1.867367e-04  1.955019e-04  2.046465e-04
## ASV11948     1.599421e-38  9.665367e-05  1.010360e-04  1.055455e-04
## ASV12912    -3.040027e-38 -1.917999e-04 -2.008451e-04 -2.102477e-04
## ASV13147    -3.040027e-38 -1.917999e-04 -2.008298e-04 -2.102310e-04
## ASV14761    -3.040027e-38 -1.917999e-04 -2.008145e-04 -2.102143e-04
## ASV8521      2.543542e-38  1.542258e-04  1.612770e-04  1.685027e-04
## ASV8581     -3.040027e-38 -1.917999e-04 -2.008044e-04 -2.102032e-04
## ASV9875     -4.820070e-39 -3.253078e-05 -3.414615e-05 -3.585534e-05
## ASV9986      1.996192e-38  1.270076e-04  1.330085e-04  1.392857e-04
## ASV2376      3.592571e-38  2.229117e-04  2.332582e-04  2.439825e-04
## ASV17535    -3.040027e-38 -1.917999e-04 -2.007937e-04 -2.101914e-04
## ASV14330    -3.040027e-38 -1.861571e-04 -1.946604e-04 -2.034824e-04
## ASV1333     -6.464688e-38 -3.868483e-04 -4.041529e-04 -4.220150e-04
## ASV2498      1.399899e-38  9.132833e-05  9.577494e-05  1.004046e-04
## ASV6352     -1.271937e-38 -7.623985e-05 -7.963501e-05 -8.315930e-05
## ASV8601     -1.560724e-38 -9.525907e-05 -9.957293e-05 -1.040688e-04
## ASV9776     -1.201910e-38 -7.137216e-05 -7.448998e-05 -7.774732e-05
## ASV1916      2.695835e-38  1.650723e-04  1.725745e-04  1.804001e-04
## ASV1555      3.012867e-39  2.055543e-05  2.155867e-05  2.264650e-05
## ASV2499      4.118412e-38  2.590629e-04  2.711912e-04  2.838422e-04
## ASV0703      3.417865e-38  2.136636e-04  2.235686e-04  2.339328e-04
## ASV2047      4.569240e-38  2.833889e-04  2.967019e-04  3.103434e-04
## ASV5492     -3.040027e-38 -1.923284e-04 -2.013906e-04 -2.108471e-04
## ASV6549     -2.922461e-39 -1.951263e-05 -2.045707e-05 -2.147244e-05
## ASV7757     -1.023691e-38 -6.792423e-05 -7.124975e-05 -7.475915e-05
## ASV0173      2.106487e-53 -1.430885e-06 -1.563536e-06 -1.710517e-06
## ASV1248     -9.723342e-39 -5.858917e-05 -6.122150e-05 -6.394305e-05
## ASV6502     -2.106487e-53  1.430888e-06  1.567534e-06  1.714836e-06
## ASV9844     -2.106487e-53  1.430889e-06  1.567302e-06  1.714575e-06
## ASV3903      1.930258e-38  1.224721e-04  1.282841e-04  1.343247e-04
## ASV8199     -9.128111e-53  1.430890e-06  1.559470e-06  1.706024e-06
## ASV3309     -1.497663e-39 -8.716180e-06 -9.095356e-06 -9.481619e-06
## ASV5826     -4.227710e-39 -2.809422e-05 -2.943239e-05 -3.088031e-05
## ASV1480     -4.064236e-38 -2.572699e-04 -2.694254e-04 -2.820821e-04
## ASV3090      8.921726e-39  5.486483e-05  5.739845e-05  6.001150e-05
## ASV0758     -2.629440e-38 -1.572807e-04 -1.644161e-04 -1.716826e-04
## ASV0811     -7.891690e-39 -4.750576e-05 -4.956644e-05 -5.176943e-05
## ASV2653      1.990638e-38  1.273400e-04  1.334063e-04  1.397370e-04
## ASV0978      2.050744e-38  1.315675e-04  1.379013e-04  1.444609e-04
## ASV6640     -4.293631e-38 -2.673489e-04 -2.798504e-04 -2.927682e-04
## ASV3423     -1.489408e-39 -1.190960e-05 -1.253818e-05 -1.325844e-05
## ASV0617      4.515055e-38  2.688460e-04  2.812933e-04  2.936747e-04
## ASV14947    -4.307029e-38 -2.700078e-04 -2.826789e-04 -2.958176e-04
## ASV18367    -2.279611e-38 -1.474061e-04 -1.544992e-04 -1.619066e-04
## ASV4574      3.460524e-38  2.077722e-04  2.171796e-04  2.268073e-04
## ASV10514    -2.275386e-38 -1.439615e-04 -1.507744e-04 -1.578509e-04
## ASV11779    -1.017620e-38 -7.115572e-05 -7.478736e-05 -7.863220e-05
## ASV7528     -3.681356e-38 -2.331148e-04 -2.441242e-04 -2.555861e-04
## ASV13153    -2.102070e-38 -1.340028e-04 -1.403497e-04 -1.469862e-04
## ASV7858     -1.867022e-38 -1.190095e-04 -1.246355e-04 -1.305281e-04
## ASV8722      7.224469e-39  4.121891e-05  4.303585e-05  4.483056e-05
## ASV6585     -4.299129e-38 -2.695078e-04 -2.820834e-04 -2.951905e-04
## ASV3311     -3.911596e-38 -2.360605e-04 -2.466401e-04 -2.576270e-04
## ASV2469      2.834923e-40  3.668478e-06  3.891183e-06  4.160877e-06
## ASV11340    -1.930957e-38 -1.170539e-04 -1.224138e-04 -1.279030e-04
## ASV1718      3.713120e-39  2.219162e-05  2.317936e-05  2.419817e-05
## ASV2117     -4.252638e-38 -2.673006e-04 -2.798353e-04 -2.928771e-04
## ASV8252     -3.040027e-38 -1.900898e-04 -1.989505e-04 -2.081753e-04
## ASV8533      6.014853e-39  3.735595e-05  3.910481e-05  4.090501e-05
## ASV9507      4.979750e-39  2.904895e-05  3.032677e-05  3.162541e-05
## ASV0706      2.094894e-38  1.347501e-04  1.411907e-04  1.479346e-04
## ASV10312    -3.040027e-38 -1.900898e-04 -1.989344e-04 -2.081575e-04
## ASV10696    -3.040027e-38 -1.900898e-04 -1.989194e-04 -2.081412e-04
## ASV11203    -3.040027e-38 -1.900898e-04 -1.989045e-04 -2.081248e-04
## ASV12147    -6.955153e-39 -4.533057e-05 -4.746037e-05 -4.975499e-05
## ASV4602     -1.531212e-39 -1.169241e-05 -1.227984e-05 -1.295966e-05
## ASV5568      1.386763e-39  9.790990e-06  1.034140e-05  1.087923e-05
## ASV6777      3.884789e-38  2.432217e-04  2.546186e-04  2.664409e-04
## ASV8749     -3.461286e-38 -2.144134e-04 -2.243383e-04 -2.346348e-04
## ASV4780      6.329642e-39  3.704349e-05  3.864167e-05  4.029911e-05
## ASV10116    -5.842740e-39 -3.607155e-05 -3.773513e-05 -3.946361e-05
## ASV2907      3.325350e-38  2.073596e-04  2.170021e-04  2.270277e-04
## ASV5165      4.196199e-38  2.689407e-04  2.817466e-04  2.951488e-04
## ASV6061      2.450198e-38  1.509999e-04  1.579597e-04  1.651698e-04
## ASV8082     -1.495458e-38 -9.358009e-05 -9.794880e-05 -1.024963e-04
## ASV7696     -1.520627e-38 -9.526004e-05 -9.974278e-05 -1.043790e-04
## ASV0550      3.310722e-39  1.920290e-05  2.013985e-05  2.100443e-05
## ASV7745      1.883305e-38  1.215187e-04  1.272937e-04  1.333870e-04
## ASV3607     -5.565427e-40 -2.692397e-06 -2.870538e-06 -2.964965e-06
## ASV3877     -3.040027e-38 -1.859760e-04 -1.946099e-04 -2.034280e-04
## ASV7667     -1.404587e-38 -8.486172e-05 -8.881232e-05 -9.278522e-05
## ASV9293     -1.115352e-38 -7.061379e-05 -7.405767e-05 -7.753529e-05
## ASV11653    -3.040027e-38 -1.859760e-04 -1.945843e-04 -2.034007e-04
## ASV12850     4.173417e-39  2.934525e-05  3.081898e-05  3.240380e-05
## ASV13104     6.083174e-39  3.542779e-05  3.692529e-05  3.849870e-05
## ASV14208    -3.040027e-38 -1.859760e-04 -1.945728e-04 -2.033885e-04
## ASV1552      2.661183e-38  1.703319e-04  1.784522e-04  1.869268e-04
## ASV2501      1.929824e-38  1.165097e-04  1.218363e-04  1.272768e-04
## ASV2893      3.675758e-38  2.306292e-04  2.413994e-04  2.526230e-04
## ASV3084      1.440920e-38  8.781109e-05  9.177463e-05  9.591578e-05
## ASV3599      1.944468e-38  1.180177e-04  1.234130e-04  1.289515e-04
## ASV3868     -3.040027e-38 -1.859760e-04 -1.945730e-04 -2.033891e-04
## ASV3917     -4.063152e-38 -2.502195e-04 -2.617966e-04 -2.737405e-04
## ASV5695      7.105051e-39  4.645896e-05  4.866788e-05  5.102526e-05
## ASV0131      4.806333e-39  2.534001e-05  2.643212e-05  2.742289e-05
## ASV2847      3.733878e-38  2.260448e-04  2.362493e-04  2.468228e-04
## ASV6875     -3.004690e-38 -1.855479e-04 -1.942221e-04 -2.031086e-04
## ASV1547     -6.256318e-38 -3.838487e-04 -4.015685e-04 -4.198110e-04
## ASV1501     -3.889959e-38 -2.410032e-04 -2.522380e-04 -2.638227e-04
## ASV3876      4.307029e-38  2.682652e-04  2.808253e-04  2.937909e-04
## ASV3456     -4.307029e-38 -2.682652e-04 -2.808040e-04 -2.937679e-04
## ASV1194      4.063904e-38  2.530032e-04  2.648038e-04  2.770226e-04
## ASV2135     -5.148054e-38 -3.235759e-04 -3.387600e-04 -3.545508e-04
## ASV1352      4.307029e-38  2.682652e-04  2.807453e-04  2.937041e-04
## ASV3208      4.892952e-38  3.051278e-04  3.193189e-04  3.340765e-04
## ASV1164     -8.881616e-42  2.315403e-06  2.353422e-06  2.576720e-06
## ASV3492      1.965333e-38  1.270837e-04  1.331667e-04  1.395557e-04
## ASV1601      2.373118e-38  1.476540e-04  1.545259e-04  1.616518e-04
## ASV5347     -3.102959e-38 -1.898687e-04 -1.985932e-04 -2.075920e-04
## ASV0293      2.284369e-38  1.425695e-04  1.491741e-04  1.560722e-04
## ASV1509      3.955336e-38  2.460291e-04  2.574817e-04  2.693465e-04
## ASV2801      5.911643e-39  3.596324e-05  3.754659e-05  3.923691e-05
## ASV2873     -8.888170e-39 -5.682793e-05 -5.952826e-05 -6.235588e-05
## ASV2162     -6.300125e-39 -3.856482e-05 -4.024332e-05 -4.206748e-05
## ASV0462      2.520726e-38  1.499902e-04  1.566383e-04  1.635211e-04
## ASV5367     -3.698323e-38 -2.322551e-04 -2.432479e-04 -2.545760e-04
## ASV2715      4.718652e-38  2.913497e-04  3.048250e-04  3.187649e-04
## ASV0371      5.916445e-38  3.582895e-04  3.748761e-04  3.916820e-04
## ASV8090     -4.017981e-38 -2.468750e-04 -2.583321e-04 -2.700853e-04
## ASV6320     -3.040027e-38 -1.918999e-04 -2.009150e-04 -2.103265e-04
## ASV2562      3.183314e-38  2.015163e-04  2.109771e-04  2.208834e-04
## ASV1505     -4.497269e-38 -2.829101e-04 -2.961594e-04 -3.099709e-04
## ASV4924     -3.514644e-38 -2.174022e-04 -2.275748e-04 -2.380036e-04
## ASV1437      3.899839e-38  2.427436e-04  2.541160e-04  2.658423e-04
## ASV3816     -3.289596e-39 -1.665658e-05 -1.735130e-05 -1.796610e-05
## ASV1969     -1.781194e-38 -1.166758e-04 -1.223983e-04 -1.283149e-04
## ASV3146      2.141451e-38  1.296606e-04  1.355519e-04  1.416216e-04
## ASV0321     -2.296600e-38 -1.401551e-04 -1.465833e-04 -1.532120e-04
## ASV1020      4.606201e-38  2.823986e-04  2.952382e-04  3.086392e-04
## ASV4138      2.717335e-39  1.939182e-05  2.029818e-05  2.135814e-05
## ASV0329     -2.484861e-38 -1.556872e-04 -1.629488e-04 -1.705129e-04
## ASV10647     4.261014e-39  2.781912e-05  2.915082e-05  3.056265e-05
## ASV3389      3.717957e-38  2.320106e-04  2.428685e-04  2.541028e-04
## ASV6880      2.145815e-38  1.262463e-04  1.317670e-04  1.374693e-04
## ASV2624     -4.081963e-39 -3.043467e-05 -3.208772e-05 -3.382818e-05
## ASV3686     -5.321176e-39 -4.308865e-05 -4.552102e-05 -4.813254e-05
## ASV12302    -3.040027e-38 -1.929840e-04 -2.020966e-04 -2.116192e-04
## ASV1184      3.829904e-38  2.371788e-04  2.482653e-04  2.596541e-04
## ASV3533     -1.727424e-38 -1.022634e-04 -1.069503e-04 -1.116105e-04
## ASV1735      9.671493e-39  5.709977e-05  5.958508e-05  6.216896e-05
## ASV0483     -1.721961e-38 -1.094354e-04 -1.146846e-04 -1.200913e-04
## ASV0928     -3.473252e-38 -2.180650e-04 -2.282966e-04 -2.389278e-04
## ASV12254    -3.040027e-38 -1.913047e-04 -2.002883e-04 -2.096379e-04
## ASV16025    -3.040027e-38 -1.913047e-04 -2.002731e-04 -2.096213e-04
## ASV3070     -3.040027e-38 -1.913047e-04 -2.002580e-04 -2.096047e-04
## ASV1850      6.876401e-39  4.481203e-05  4.690614e-05  4.917041e-05
## ASV8946     -3.040027e-38 -1.881795e-04 -1.969569e-04 -2.059887e-04
## ASV1536      2.557608e-38  1.578365e-04  1.651769e-04  1.727255e-04
## ASV4151      3.870283e-38  2.377255e-04  2.486534e-04  2.599624e-04
## ASV4585      5.197050e-38  3.192318e-04  3.338960e-04  3.490789e-04
## ASV4921     -1.272239e-38 -7.730103e-05 -8.086464e-05 -8.449181e-05
## ASV6172      3.040027e-38  1.881795e-04  1.969160e-04  2.059444e-04
## ASV6375     -3.040027e-38 -1.881795e-04 -1.969012e-04 -2.059284e-04
## ASV6501      3.553280e-38  2.148570e-04  2.245408e-04  2.345829e-04
## ASV17095    -3.040027e-38 -1.881795e-04 -1.968897e-04 -2.059160e-04
## ASV3679     -3.040027e-38 -1.881795e-04 -1.968750e-04 -2.058999e-04
## ASV5750      3.040027e-38  1.881795e-04  1.968603e-04  2.058839e-04
## ASV5922     -3.040027e-38 -1.881795e-04 -1.968456e-04 -2.058679e-04
## ASV7323     -3.040027e-38 -1.881795e-04 -1.968309e-04 -2.058519e-04
## ASV8515     -2.858717e-40 -2.598609e-06 -2.702473e-06 -2.861475e-06
## ASV8753     -3.040027e-38 -1.881794e-04 -1.968162e-04 -2.058357e-04
## ASV9197      2.076763e-38  1.291278e-04  1.351825e-04  1.414097e-04
## ASV1778      5.136227e-39  3.472629e-05  3.646327e-05  3.828883e-05
## ASV1241      3.956938e-38  2.430169e-04  2.541384e-04  2.656919e-04
## ASV1717      3.063194e-38  1.897597e-04  1.984548e-04  2.075613e-04
## ASV1112      3.616744e-38  2.185370e-04  2.284376e-04  2.386396e-04
## ASV3994      4.074550e-38  2.549915e-04  2.669419e-04  2.793187e-04
## ASV5511     -3.040027e-38 -1.889268e-04 -1.977285e-04 -2.068349e-04
## ASV8706      2.142665e-38  1.368746e-04  1.433957e-04  1.501938e-04
## ASV3049     -3.040027e-38 -1.889268e-04 -1.977165e-04 -2.068218e-04
## ASV4332      1.914390e-38  1.211334e-04  1.268165e-04  1.327647e-04
## ASV7411      3.529400e-38  2.148453e-04  2.245984e-04  2.347083e-04
## ASV7475     -3.040027e-38 -1.889268e-04 -1.977103e-04 -2.068152e-04
## ASV8988     -3.040027e-38 -1.889268e-04 -1.976954e-04 -2.067990e-04
## ASV0688     -6.647944e-38 -4.045767e-04 -4.230103e-04 -4.420537e-04
## ASV1946      1.854258e-38  1.096839e-04  1.145261e-04  1.195199e-04
## ASV3150      5.106883e-38  3.143990e-04  3.288784e-04  3.438665e-04
## ASV3508      2.562418e-38  1.541181e-04  1.610609e-04  1.682135e-04
## ASV3863     -3.040027e-38 -1.889268e-04 -1.976850e-04 -2.067876e-04
## ASV4544      2.482682e-38  1.491812e-04  1.558866e-04  1.628017e-04
## ASV4567      5.501723e-38  3.410066e-04  3.567654e-04  3.731471e-04
## ASV4855     -3.040027e-38 -1.889268e-04 -1.976696e-04 -2.067709e-04
## ASV4872      4.113850e-38  2.524147e-04  2.640128e-04  2.760007e-04
## ASV4881      2.854517e-38  1.810449e-04  1.895962e-04  1.985176e-04
## ASV5283      3.040027e-38  1.889268e-04  1.976576e-04  2.067577e-04
## ASV5302      3.622971e-38  2.233181e-04  2.335805e-04  2.442584e-04
## ASV5909      3.061925e-38  1.896020e-04  1.983835e-04  2.074810e-04
## ASV5933      2.277910e-38  1.414703e-04  1.480566e-04  1.548680e-04
## ASV6019      3.497173e-38  2.102741e-04  2.197388e-04  2.295013e-04
## ASV6043      1.313814e-38  8.385867e-05  8.784040e-05  9.199932e-05
## ASV6908      3.824426e-38  2.368505e-04  2.478355e-04  2.592050e-04
## ASV7245     -3.040027e-38 -1.889268e-04 -1.976657e-04 -2.067664e-04
## ASV7249     -3.040027e-38 -1.889268e-04 -1.976509e-04 -2.067503e-04
## ASV8349      1.007799e-38  6.353269e-05  6.651894e-05  6.962854e-05
## ASV7310     -3.040027e-38 -1.889268e-04 -1.976388e-04 -2.067370e-04
## ASV1893      2.391447e-38  1.466960e-04  1.533725e-04  1.603440e-04
## ASV2354      1.911282e-38  1.132842e-04  1.182654e-04  1.234373e-04
## ASV3435     -5.448955e-39 -3.181569e-05 -3.320433e-05 -3.462775e-05
## ASV0480      4.629385e-38  2.928217e-04  3.066051e-04  3.209760e-04
## ASV0955     -1.611560e-38 -1.017329e-04 -1.065078e-04 -1.114966e-04
## ASV10000     1.020886e-38  5.812879e-05  6.049974e-05  6.300982e-05
## ASV7215     -1.919022e-38 -1.218002e-04 -1.276170e-04 -1.336246e-04
## ASV10423    -4.307029e-38 -2.673359e-04 -2.798107e-04 -2.926796e-04
## ASV6008     -2.295054e-38 -1.427712e-04 -1.494599e-04 -1.563504e-04
## ASV9330     -4.307029e-38 -2.673359e-04 -2.797798e-04 -2.926461e-04
## ASV6051      4.307029e-38  2.673359e-04  2.797587e-04  2.926232e-04
## ASV1675      2.850556e-38  1.766986e-04  1.849573e-04  1.934524e-04
## ASV2043      1.796313e-38  1.143165e-04  1.196759e-04  1.253255e-04
## ASV3634      1.657424e-38  1.073097e-04  1.124428e-04  1.178483e-04
## ASV4077     -4.307029e-38 -2.673359e-04 -2.797484e-04 -2.926122e-04
## ASV4754      2.111215e-38  1.295542e-04  1.355087e-04  1.416643e-04
## ASV6095      5.041514e-38  3.074431e-04  3.214455e-04  3.359546e-04
## ASV6288      3.701042e-38  2.272036e-04  2.376571e-04  2.484550e-04
## ASV6507     -4.307029e-38 -2.673359e-04 -2.797356e-04 -2.925982e-04
## ASV8905      2.217060e-38  1.359803e-04  1.422097e-04  1.486680e-04
## ASV9728     -4.307029e-38 -2.673359e-04 -2.797182e-04 -2.925793e-04
## ASV11144    -4.307029e-38 -2.673359e-04 -2.796972e-04 -2.925565e-04
## ASV1615     -1.709114e-38 -1.074288e-04 -1.124152e-04 -1.176496e-04
## ASV2709     -5.265615e-38 -3.261790e-04 -3.412231e-04 -3.568765e-04
## ASV3003      4.124255e-38  2.582661e-04  2.703525e-04  2.829077e-04
## ASV5163     -3.973936e-38 -2.464743e-04 -2.578172e-04 -2.696584e-04
## ASV6622      2.738557e-38  1.727279e-04  1.808500e-04  1.893119e-04
## ASV1076     -4.094550e-38 -2.551633e-04 -2.669443e-04 -2.792684e-04
## ASV7895      1.010756e-38  6.074772e-05  6.343775e-05  6.624779e-05
## ASV10577    -3.040027e-38 -1.928987e-04 -2.020160e-04 -2.115314e-04
## ASV1272      3.040027e-38  1.928987e-04  2.020005e-04  2.115145e-04
## ASV2492     -1.394931e-38 -9.461253e-05 -9.932116e-05 -1.043102e-04
## ASV5195      3.716463e-38  2.321816e-04  2.429891e-04  2.542438e-04
## ASV5267      2.283564e-38  1.401888e-04  1.465987e-04  1.532559e-04
## ASV6317      3.129533e-38  1.974014e-04  2.066831e-04  2.163512e-04
## ASV2296      1.134976e-38  7.105442e-05  7.433086e-05  7.778684e-05
## ASV2290     -2.862878e-38 -1.747503e-04 -1.827382e-04 -1.909943e-04
## ASV3726      2.369877e-38  1.510246e-04  1.581759e-04  1.656546e-04
## ASV1169      2.077988e-38  1.282697e-04  1.342021e-04  1.403385e-04
## ASV0189     -1.913851e-38 -1.222784e-04 -1.280991e-04 -1.341725e-04
## ASV2729      7.315664e-38  4.635352e-04  4.852947e-04  5.080957e-04
## ASV3469      1.681316e-38  1.055506e-04  1.104588e-04  1.156005e-04
## ASV0762     -4.132117e-38 -2.523827e-04 -2.638736e-04 -2.757956e-04
## ASV9001     -3.942320e-38 -2.338743e-04 -2.447174e-04 -2.554491e-04
## ASV14604    -3.040027e-38 -1.875363e-04 -1.962898e-04 -2.052590e-04
## ASV7439      8.355129e-39  5.513076e-05  5.774817e-05  6.057457e-05
## ASV8625     -3.040027e-38 -1.875363e-04 -1.962775e-04 -2.052458e-04
## ASV11553     5.453855e-39  3.649723e-05  3.824553e-05  4.014239e-05
## ASV14440     1.807961e-39  5.557487e-06  5.529468e-06  5.497494e-06
## ASV16106    -3.040027e-38 -1.875363e-04 -1.962645e-04 -2.052319e-04
## ASV16110    -3.040027e-38 -1.875363e-04 -1.962497e-04 -2.052160e-04
## ASV2229      5.454727e-38  3.317481e-04  3.467966e-04  3.623987e-04
## ASV3854     -2.940801e-38 -1.814868e-04 -1.899200e-04 -1.986008e-04
## ASV5512     -3.040027e-38 -1.875363e-04 -1.962298e-04 -2.051947e-04
## ASV5939      4.051032e-38  2.517148e-04  2.633768e-04  2.755003e-04
## ASV6676     -2.099735e-38 -1.296288e-04 -1.356335e-04 -1.418343e-04
## ASV8381     -3.040027e-38 -1.875363e-04 -1.961968e-04 -2.051588e-04
## ASV2735      3.819536e-38  2.383531e-04  2.494871e-04  2.610226e-04
## ASV9816     -3.040027e-38 -1.875363e-04 -1.961870e-04 -2.051481e-04
## ASV1382      1.413492e-38  8.485637e-05  8.849882e-05  9.241991e-05
## ASV1408     -3.040027e-38 -1.880497e-04 -1.968391e-04 -2.058636e-04
## ASV4902      1.822626e-38  1.188619e-04  1.245469e-04  1.305726e-04
## ASV5600      2.358151e-38  1.456094e-04  1.522415e-04  1.592028e-04
## ASV0815     -6.893418e-39 -4.095596e-05 -4.273514e-05 -4.460409e-05
## ASV11867    -3.040027e-38 -1.880497e-04 -1.968314e-04 -2.058555e-04
## ASV16064    -3.040027e-38 -1.880497e-04 -1.968165e-04 -2.058395e-04
## ASV2250      3.778290e-38  2.360710e-04  2.470556e-04  2.584994e-04
## ASV2417      8.393779e-39  5.498759e-05  5.762734e-05  6.042548e-05
## ASV2807      5.078724e-38  3.078239e-04  3.218364e-04  3.362687e-04
## ASV3224     -3.040027e-38 -1.880496e-04 -1.967824e-04 -2.058026e-04
## ASV4115     -3.040027e-38 -1.880496e-04 -1.967676e-04 -2.057866e-04
## ASV4876      5.076969e-39  3.090318e-05  3.228119e-05  3.372790e-05
## ASV5291      3.000267e-38  1.833589e-04  1.917662e-04  2.004362e-04
## ASV5834      1.431891e-38  8.883356e-05  9.290578e-05  9.717113e-05
## ASV6896      3.600296e-39  2.089096e-05  2.175596e-05  2.267752e-05
## ASV7292     -3.040027e-38 -1.880496e-04 -1.967584e-04 -2.057767e-04
## ASV7924      1.717234e-38  1.079163e-04  1.129925e-04  1.182582e-04
## ASV0710      4.053541e-38  2.490368e-04  2.604155e-04  2.722530e-04
## ASV1925      3.557084e-38  2.169160e-04  2.268056e-04  2.370357e-04
## ASV4247     -3.040027e-38 -1.880496e-04 -1.967423e-04 -2.057592e-04
## ASV4549     -3.040027e-38 -1.880496e-04 -1.967276e-04 -2.057432e-04
## ASV4076      2.540680e-38  1.573982e-04  1.646470e-04  1.722062e-04
## ASV7063      2.439439e-38  1.527193e-04  1.598376e-04  1.672491e-04
## ASV1487      2.692193e-38  1.626816e-04  1.700131e-04  1.776056e-04
## ASV1405      1.037653e-38  6.696370e-05  7.020605e-05  7.356742e-05
## ASV3851      2.625913e-38  1.665276e-04  1.743868e-04  1.825837e-04
## ASV0896      8.120745e-39  5.092518e-05  5.324646e-05  5.572062e-05
## ASV5581      3.805940e-38  2.421543e-04  2.536292e-04  2.656057e-04
## ASV7053     -1.285656e-38 -7.996892e-05 -8.369233e-05 -8.755161e-05
## ASV7171     -3.040027e-38 -1.916490e-04 -2.006501e-04 -2.100354e-04
## ASV4017     -4.180093e-38 -2.625097e-04 -2.747755e-04 -2.875725e-04
## ASV5846      4.010423e-39  1.723843e-05  1.770025e-05  1.812655e-05
## ASV0203      7.819022e-40  2.034192e-06  1.951967e-06  1.917056e-06
## ASV13271     5.305006e-39  3.018169e-05  3.141730e-05  3.272029e-05
## ASV9487      2.095671e-38  1.213688e-04  1.265644e-04  1.319491e-04
## ASV2056     -4.300127e-38 -2.690723e-04 -2.816017e-04 -2.946628e-04
## ASV16933    -4.306987e-38 -2.651995e-04 -2.775325e-04 -2.901936e-04
## ASV0360      1.918749e-38  1.155774e-04  1.207641e-04  1.261452e-04
## ASV1798     -2.802420e-38 -1.725057e-04 -1.805041e-04 -1.887340e-04
## ASV17286    -3.040027e-38 -1.914653e-04 -2.004564e-04 -2.098217e-04
## ASV8175     -3.040027e-38 -1.914653e-04 -2.004412e-04 -2.098050e-04
## ASV6679      3.296473e-38  2.032509e-04  2.125905e-04  2.222934e-04
## ASV6776      1.622943e-38  9.825720e-05  1.027215e-04  1.073166e-04
## ASV9062     -3.040027e-38 -1.914653e-04 -2.004275e-04 -2.097900e-04
## ASV9564     -2.383930e-39 -1.677447e-05 -1.760784e-05 -1.852284e-05
## ASV6431     -3.040027e-38 -1.914653e-04 -2.004113e-04 -2.097721e-04
## ASV9940      1.268056e-38  7.828570e-05  8.188743e-05  8.562720e-05
## ASV7001     -4.306965e-38 -2.656047e-04 -2.779110e-04 -2.906028e-04
## ASV3044      4.866605e-38  3.000383e-04  3.138253e-04  3.281566e-04
## ASV6684      1.701217e-38  1.102322e-04  1.155467e-04  1.211028e-04
## ASV12278    -6.143921e-54  1.530461e-06  1.693128e-06  1.849665e-06
## ASV3543     -2.973498e-38 -1.782008e-04 -1.861640e-04 -1.944111e-04
## ASV6397     -6.143921e-54  1.530455e-06  1.690047e-06  1.846338e-06
## ASV9939     -6.143921e-54  1.530455e-06  1.689777e-06  1.846060e-06
## ASV9432      2.421299e-38  1.543643e-04  1.616790e-04  1.693263e-04
## ASV2630     -3.036049e-38 -1.921425e-04 -2.011898e-04 -2.106340e-04
## ASV2175      3.981968e-38  2.521290e-04  2.640616e-04  2.764709e-04
## ASV4107      3.313480e-38  2.081726e-04  2.178987e-04  2.280472e-04
## ASV9172     -3.754861e-39 -2.613361e-05 -2.751212e-05 -2.893022e-05
## ASV3141      3.886221e-38  2.473233e-04  2.590304e-04  2.712651e-04
## ASV9010     -3.040027e-38 -1.918541e-04 -2.008996e-04 -2.103073e-04
## ASV2550      3.065648e-38  1.904841e-04  1.992763e-04  2.084471e-04
## ASV5845     -3.040027e-38 -1.918541e-04 -2.008891e-04 -2.102959e-04
## ASV3998      3.040027e-38  1.918541e-04  2.008738e-04  2.102792e-04
## ASV1389     -3.519234e-38 -2.084464e-04 -2.178756e-04 -2.274081e-04
## ASV0615     -3.494985e-38 -2.170379e-04 -2.270969e-04 -2.375498e-04
## ASV9127     -4.295812e-38 -2.660239e-04 -2.784425e-04 -2.912200e-04
## ASV1190      6.227206e-38  3.791995e-04  3.964633e-04  4.143238e-04
## ASV1211      1.540939e-38  9.543088e-05  9.975473e-05  1.043344e-04
## ASV1766     -4.387851e-38 -2.733618e-04 -2.861759e-04 -2.993903e-04
## ASV2337      3.040027e-38  1.901482e-04  1.991446e-04  2.083800e-04
## ASV2463      6.547162e-39  4.089291e-05  4.288063e-05  4.486720e-05
## ASV2806      2.350639e-38  1.426239e-04  1.489910e-04  1.556859e-04
## ASV0439     -3.933876e-38 -2.450859e-04 -2.565738e-04 -2.684196e-04
## ASV0839      3.657136e-38  2.330023e-04  2.439795e-04  2.555045e-04
## ASV14975    -3.040027e-38 -1.901482e-04 -1.991175e-04 -2.083510e-04
## ASV17712    -3.040027e-38 -1.901482e-04 -1.991023e-04 -2.083347e-04
## ASV2010     -3.617871e-39 -2.172256e-05 -2.274884e-05 -2.375531e-05
## ASV2041      1.522290e-38  9.914111e-05  1.039512e-04  1.089710e-04
## ASV2124     -3.911540e-38 -2.452818e-04 -2.568207e-04 -2.687616e-04
## ASV2585      5.467705e-38  3.399271e-04  3.556852e-04  3.720660e-04
## ASV3314      4.261380e-38  2.685663e-04  2.811930e-04  2.943385e-04
## ASV5051     -4.435826e-39 -2.508472e-05 -2.619652e-05 -2.727019e-05
## ASV10784     1.549939e-38  9.565357e-05  1.000253e-04  1.045960e-04
## ASV3279     -3.040027e-38 -1.901482e-04 -1.990656e-04 -2.082950e-04
## ASV9498      2.517739e-39  1.352281e-05  1.403866e-05  1.457595e-05
## ASV1059     -3.201432e-38 -2.026505e-04 -2.121973e-04 -2.221637e-04
## ASV13008    -3.040027e-38 -1.901482e-04 -1.990501e-04 -2.082783e-04
## ASV15803    -3.040027e-38 -1.901482e-04 -1.990350e-04 -2.082619e-04
## ASV2559     -2.948843e-38 -1.845434e-04 -1.931675e-04 -2.021286e-04
## ASV2623     -3.040027e-38 -1.901482e-04 -1.990204e-04 -2.082459e-04
## ASV2802     -1.729596e-38 -1.069996e-04 -1.119754e-04 -1.171079e-04
## ASV3799      4.722875e-38  2.924438e-04  3.059715e-04  3.200077e-04
## ASV5274      2.926160e-40 -1.213347e-07 -1.623213e-07 -2.675312e-07
## ASV5835      1.840073e-38  1.170396e-04  1.225568e-04  1.283454e-04
## ASV7251     -3.040027e-38 -1.901482e-04 -1.990171e-04 -2.082422e-04
## ASV7616     -3.040027e-38 -1.901482e-04 -1.990020e-04 -2.082258e-04
## ASV9576     -3.040027e-38 -1.901482e-04 -1.989871e-04 -2.082094e-04
## ASV2870      2.222798e-38  1.393236e-04  1.458032e-04  1.525742e-04
## ASV3668     -1.934353e-38 -1.223508e-04 -1.280557e-04 -1.340585e-04
## ASV1633      1.449813e-38  9.240424e-05  9.678811e-05  1.013647e-04
## ASV6060      5.336585e-40 -2.832430e-06 -3.274915e-06 -3.734563e-06
## ASV6305      1.504178e-38  9.556114e-05  1.000784e-04  1.047954e-04
## ASV5164      1.050440e-38  6.259282e-05  6.537352e-05  6.824256e-05
## ASV7252     -3.040027e-38 -1.904667e-04 -1.993953e-04 -2.086594e-04
## ASV9343      2.549441e-38  1.637330e-04  1.715343e-04  1.797115e-04
## ASV6835     -5.243379e-39 -3.195744e-05 -3.342867e-05 -3.493621e-05
## ASV1264      3.746140e-38  2.322761e-04  2.429997e-04  2.541654e-04
## ASV0591      4.302786e-39  2.120185e-05  2.191394e-05  2.264048e-05
## ASV1351      4.271102e-38  2.678640e-04  2.803971e-04  2.934361e-04
## ASV14224    -3.040027e-38 -1.904667e-04 -1.993581e-04 -2.086189e-04
## ASV1432     -3.040027e-38 -1.904667e-04 -1.993430e-04 -2.086024e-04
## ASV1559     -2.528411e-38 -1.594524e-04 -1.669557e-04 -1.747647e-04
## ASV2182      4.778811e-38  2.962242e-04  3.099238e-04  3.241558e-04
## ASV2304     -2.708802e-39 -1.601150e-05 -1.670363e-05 -1.742935e-05
## ASV6838     -3.142838e-40 -1.672932e-06 -1.740085e-06 -1.806565e-06
## ASV1125     -4.350800e-39 -2.838401e-05 -2.976986e-05 -3.121142e-05
## ASV17948    -3.040027e-38 -1.904667e-04 -1.993376e-04 -2.085964e-04
## ASV2609      2.655132e-38  1.677912e-04  1.756864e-04  1.839219e-04
## ASV6128     -2.466133e-38 -1.560803e-04 -1.634252e-04 -1.710617e-04
## ASV1338      6.928014e-39  3.829831e-05  3.985094e-05  4.144080e-05
## ASV2136      1.168449e-38  6.962873e-05  7.270889e-05  7.590550e-05
## ASV0929     -2.820965e-38 -1.741655e-04 -1.821933e-04 -1.905272e-04
## ASV3479      1.970806e-38  1.201861e-04  1.258171e-04  1.314954e-04
## ASV0886      5.136435e-38  3.203104e-04  3.350813e-04  3.505603e-04
## ASV1652      2.340602e-38  1.468980e-04  1.537459e-04  1.609022e-04
## ASV1160      4.237225e-38  2.655264e-04  2.779175e-04  2.908296e-04
## ASV5260     -7.373515e-39 -4.969674e-05 -5.221326e-05 -5.481669e-05
## ASV2352      5.398417e-38  3.273339e-04  3.419761e-04  3.573119e-04
## ASV0986     -2.115293e-38 -1.295719e-04 -1.355023e-04 -1.416486e-04
## ASV2021      3.465695e-38  2.146963e-04  2.245627e-04  2.348670e-04
## ASV16599    -2.647078e-38 -1.746005e-04 -1.831446e-04 -1.920768e-04
## ASV3497      2.586345e-38  1.628295e-04  1.704221e-04  1.783828e-04
## ASV1305      1.673612e-38  1.091381e-04  1.143720e-04  1.198884e-04
## ASV0927     -4.266149e-38 -2.519204e-04 -2.629780e-04 -2.744173e-04
## ASV0647     -1.441760e-38 -8.332916e-05 -8.671363e-05 -9.038312e-05
## ASV1832     -1.733868e-38 -1.067927e-04 -1.116805e-04 -1.167754e-04
## ASV1277      2.048258e-38  1.271360e-04  1.329484e-04  1.390577e-04
## ASV22332    -3.040027e-38 -1.908312e-04 -1.997726e-04 -2.090723e-04
## ASV10080    -2.446061e-39 -2.302014e-05 -2.444863e-05 -2.596897e-05
## ASV14157     3.867611e-39  2.549700e-05  2.673826e-05  2.804568e-05
## ASV15829    -3.040027e-38 -1.908312e-04 -1.997570e-04 -2.090553e-04
## ASV3609     -3.040027e-38 -1.908312e-04 -1.997419e-04 -2.090388e-04
## ASV5737      7.314901e-39  4.282641e-05  4.471077e-05  4.663118e-05
## ASV1474      2.202122e-38  1.390647e-04  1.456286e-04  1.524442e-04
## ASV2028      3.244789e-38  1.915866e-04  2.000299e-04  2.087303e-04
## ASV0818      3.682930e-38  2.295910e-04  2.402419e-04  2.513380e-04
## ASV0505     -3.143796e-38 -1.984266e-04 -2.077189e-04 -2.174329e-04
## ASV1813      1.571428e-38  9.418886e-05  9.837599e-05  1.027263e-04
## ASV0512      3.207171e-38  2.057845e-04  2.154936e-04  2.257230e-04
## ASV5374     -2.330037e-38 -1.459687e-04 -1.528489e-04 -1.599570e-04
## ASV2927     -4.137624e-39 -1.947078e-05 -2.016972e-05 -2.077425e-05
## ASV3596      2.376141e-38  1.437805e-04  1.503764e-04  1.571040e-04
## ASV1137      1.438563e-38  8.598870e-05  8.987838e-05  9.383753e-05
## ASV4541      2.106487e-53  1.952358e-06  2.084692e-06  2.279736e-06
## ASV9872     -2.106487e-53 -1.952358e-06 -2.084468e-06 -2.279389e-06
## ASV0359     -1.119999e-38 -6.740368e-05 -7.046592e-05 -7.359740e-05
## ASV0720     -1.891173e-38 -1.149853e-04 -1.202130e-04 -1.256140e-04
## ASV10545    -2.106487e-53 -1.952360e-06 -2.093533e-06 -2.289060e-06
## ASV13384    -2.106487e-53 -1.952360e-06 -2.093294e-06 -2.288713e-06
## ASV1456      8.683763e-40  5.031627e-06  5.264267e-06  5.488839e-06
## ASV1751     -2.106487e-53 -1.952359e-06 -2.093304e-06 -2.288617e-06
## ASV18419    -2.106487e-53 -1.952359e-06 -2.093065e-06 -2.288270e-06
## ASV2970      2.106487e-53  1.952359e-06  2.092827e-06  2.287924e-06
## ASV4215      2.393974e-38  1.491568e-04  1.560465e-04  1.632469e-04
## ASV4742      4.532485e-39  2.515511e-05  2.623482e-05  2.729110e-05
## ASV5017      7.831685e-39  4.720189e-05  4.934989e-05  5.154769e-05
## ASV5139     -2.106487e-53 -1.952361e-06 -2.090722e-06 -2.285322e-06
## ASV9133     -2.106487e-53 -1.952361e-06 -2.090487e-06 -2.284977e-06
## ASV9447     -2.106487e-53 -1.952361e-06 -2.090254e-06 -2.284631e-06
## ASV0842     -2.413783e-38 -1.426757e-04 -1.489361e-04 -1.554283e-04
## ASV12293     1.725664e-38  1.001882e-04  1.045396e-04  1.090004e-04
## ASV1965      2.844644e-38  1.790447e-04  1.874457e-04  1.961979e-04
## ASV2005      3.328825e-38  1.972640e-04  2.060169e-04  2.150186e-04
## ASV5335      2.442849e-38  1.465528e-04  1.531782e-04  1.599636e-04
## ASV6438     -2.106487e-53 -1.952407e-06 -2.112397e-06 -2.308435e-06
## ASV7798     -2.106487e-53 -1.952406e-06 -2.112127e-06 -2.308087e-06
## ASV2691     -3.211971e-38 -2.017102e-04 -2.110857e-04 -2.209079e-04
## ASV9958      2.687628e-38  1.653211e-04  1.729277e-04  1.808031e-04
## ASV1512      9.289094e-39  5.968118e-05  6.254555e-05  6.553228e-05
## ASV1226      4.374569e-38  2.711604e-04  2.837823e-04  2.968215e-04
## ASV2130     -7.723118e-38 -4.785217e-04 -5.006904e-04 -5.236748e-04
## ASV0874     -2.421411e-38 -1.489597e-04 -1.558948e-04 -1.630141e-04
## ASV5436     -3.400927e-38 -2.127463e-04 -2.226497e-04 -2.329692e-04
## ASV0383     -3.945801e-38 -2.360391e-04 -2.465237e-04 -2.574045e-04
## ASV1882      3.860660e-38  2.307050e-04  2.410792e-04  2.517258e-04
## ASV2471     -2.097231e-38 -1.296294e-04 -1.357571e-04 -1.419774e-04
## ASV4049     -2.992334e-38 -1.844698e-04 -1.929303e-04 -2.017354e-04
## ASV3014     -1.716087e-38 -1.035414e-04 -1.082522e-04 -1.130790e-04
## ASV0316     -5.955330e-38 -3.692079e-04 -3.863331e-04 -4.040803e-04
## ASV1621     -4.188630e-38 -2.565615e-04 -2.683354e-04 -2.805039e-04
## ASV13266    -3.040027e-38 -1.880310e-04 -1.967731e-04 -2.057903e-04
## ASV1635     -3.015365e-38 -1.864703e-04 -1.951243e-04 -2.040637e-04
## ASV2042      2.212274e-38  1.370036e-04  1.433097e-04  1.498845e-04
## ASV2317     -3.625878e-38 -2.236060e-04 -2.339473e-04 -2.446332e-04
## ASV3697      2.775612e-38  1.693528e-04  1.770052e-04  1.849948e-04
## ASV6404      5.135272e-38  3.117925e-04  3.258395e-04  3.404771e-04
## ASV15616     1.598885e-39  1.252583e-05  1.318534e-05  1.392581e-05
## ASV10783    -3.040027e-38 -1.880310e-04 -1.967413e-04 -2.057561e-04
## ASV6912     -2.295194e-38 -1.411980e-04 -1.477063e-04 -1.544343e-04
## ASV1561      6.267759e-38  3.821985e-04  3.995751e-04  4.176061e-04
## ASV4404      4.212588e-38  2.600586e-04  2.720251e-04  2.844630e-04
## ASV1110      3.118002e-38  1.911420e-04  1.999124e-04  2.089835e-04
## ASV2844     -9.956794e-39 -6.424874e-05 -6.732303e-05 -7.054615e-05
## ASV5224      3.087616e-38  1.905833e-04  1.993904e-04  2.085025e-04
## ASV6300     -3.040027e-38 -1.906282e-04 -1.995356e-04 -2.088123e-04
## ASV8078     -3.040027e-38 -1.906282e-04 -1.995205e-04 -2.087959e-04
## ASV9722      7.638763e-40  1.322776e-06  1.273931e-06  1.155460e-06
## ASV6911     -3.040027e-38 -1.906282e-04 -1.995054e-04 -2.087793e-04
## ASV5474     -5.969814e-39 -3.880982e-05 -4.069483e-05 -4.265848e-05
## ASV2761     -7.256661e-38 -4.479138e-04 -4.685483e-04 -4.899670e-04
## ASV5943     -1.912214e-38 -1.236351e-04 -1.295870e-04 -1.358092e-04
## ASV0600     -6.366108e-39 -3.334988e-05 -3.469497e-05 -3.597916e-05
## ASV0608     -6.544018e-38 -4.021406e-04 -4.205838e-04 -4.397245e-04
## ASV1586      1.615427e-38  9.723264e-05  1.015491e-04  1.060698e-04
## ASV0206     -7.391413e-38 -4.478934e-04 -4.679175e-04 -4.888743e-04
## ASV4042     -3.297802e-38 -2.043479e-04 -2.137771e-04 -2.235893e-04
## ASV5304     -7.902358e-40 -5.910096e-06 -6.262520e-06 -6.599728e-06
## ASV0949     -9.954426e-39 -6.976028e-05 -7.336635e-05 -7.714917e-05
## ASV1856      3.790633e-38  2.353501e-04  2.461986e-04  2.575195e-04
## ASV2584      4.811356e-39  2.807272e-05  2.929520e-05  3.054228e-05
## ASV2287     -6.997076e-40 -1.106480e-05 -1.153362e-05 -1.238952e-05
## ASV2364     -5.420195e-38 -3.341246e-04 -3.495929e-04 -3.655579e-04
## ASV11481    -4.194247e-38 -2.653106e-04 -2.778538e-04 -2.908919e-04
## ASV2906     -1.450658e-38 -9.231112e-05 -9.662339e-05 -1.011809e-04
## ASV0161     -1.798367e-38 -1.108666e-04 -1.159217e-04 -1.212094e-04
## ASV0062     -1.180453e-37 -7.282112e-04 -7.617574e-04 -7.965580e-04
## ASV3811     -2.980117e-38 -1.730739e-04 -1.810806e-04 -1.888326e-04
## ASV0225      5.662909e-39  2.937864e-05  3.066917e-05  3.179734e-05
## ASV4672     -3.832617e-38 -2.336203e-04 -2.444883e-04 -2.555206e-04
## ASV1607     -2.685569e-39 -1.764699e-05 -1.850688e-05 -1.939515e-05
## ASV3060      7.063015e-39  4.582185e-05  4.802157e-05  5.033403e-05
## ASV2275     -5.375482e-39 -3.331198e-05 -3.484389e-05 -3.644276e-05
## ASV5375      2.043085e-38  1.299111e-04  1.360118e-04  1.424283e-04
## ASV0352     -6.192788e-38 -3.888798e-04 -4.071128e-04 -4.260695e-04
## ASV1107      1.733099e-38  1.118667e-04  1.170582e-04  1.226487e-04
## ASV4887      1.718053e-38  1.020024e-04  1.065120e-04  1.111718e-04
## ASV2397     -9.028261e-39 -5.176336e-05 -5.392783e-05 -5.618596e-05
## ASV7541     -1.993270e-38 -1.223339e-04 -1.280235e-04 -1.338388e-04
## ASV7387     -4.302709e-38 -2.672686e-04 -2.796719e-04 -2.925400e-04
## ASV1355      3.917059e-38  2.448450e-04  2.562816e-04  2.681627e-04
## ASV1764     -2.085633e-38 -1.280635e-04 -1.339308e-04 -1.400211e-04
## ASV1960     -4.042510e-38 -2.368067e-04 -2.476214e-04 -2.583191e-04
## ASV0484     -7.299950e-39 -4.521144e-05 -4.728820e-05 -4.945939e-05
## ASV2487      1.291002e-38  7.405702e-05  7.712177e-05  8.035695e-05
## ASV0422      3.880713e-38  2.298089e-04  2.403809e-04  2.508994e-04
## ASV0081     -2.232702e-38 -1.425361e-04 -1.492975e-04 -1.563713e-04
## ASV1341     -2.079569e-38 -1.241630e-04 -1.296945e-04 -1.354084e-04
## ASV1001     -4.892692e-38 -2.937031e-04 -3.067659e-04 -3.203586e-04
## ASV0317     -1.068471e-38 -7.039165e-05 -7.359957e-05 -7.717667e-05
## ASV2728     -3.277736e-38 -2.028971e-04 -2.123466e-04 -2.220885e-04
## ASV0884     -4.023153e-38 -2.591340e-04 -2.713716e-04 -2.843340e-04
## ASV0464      7.463143e-39  5.458217e-05  5.746750e-05  6.053813e-05
## ASV2963      2.928852e-38  1.782162e-04  1.862593e-04  1.946485e-04
## ASV4608      1.297067e-38  8.030720e-05  8.400718e-05  8.785700e-05
## ASV3534      3.394669e-38  2.006534e-04  2.094651e-04  2.185853e-04
## ASV0291     -2.814970e-38 -1.719970e-04 -1.798012e-04 -1.879255e-04
## ASV0635     -3.916218e-38 -2.470218e-04 -2.585954e-04 -2.706939e-04
## ASV0867      3.102547e-38  1.984717e-04  2.079015e-04  2.177720e-04
## ASV1206     -4.078787e-39 -2.339819e-05 -2.439738e-05 -2.541795e-05
## ASV1230      1.272669e-53 -1.265535e-06 -1.378581e-06 -1.509575e-06
## ASV1265      8.577871e-39  5.305895e-05  5.550061e-05  5.804528e-05
## ASV1291     -2.585478e-38 -1.633595e-04 -1.710165e-04 -1.790292e-04
## ASV1524      5.610366e-38  3.390966e-04  3.543108e-04  3.701364e-04
## ASV2153     -4.330589e-38 -2.616073e-04 -2.733591e-04 -2.855715e-04
## ASV2714     -1.272669e-53  1.265481e-06  1.356915e-06  1.485953e-06
## ASV4246      1.272669e-53 -1.265481e-06 -1.356760e-06 -1.485724e-06
## ASV0945      2.803351e-38  1.736239e-04  1.816268e-04  1.899554e-04
## ASV2380      6.686867e-38  4.045924e-04  4.227792e-04  4.416956e-04
## ASV0214     -1.148976e-38 -6.178379e-05 -6.418947e-05 -6.666249e-05
## ASV10461     1.228784e-53 -1.265492e-06 -1.380158e-06 -1.511222e-06
## ASV4177      2.024045e-38  1.188520e-04  1.240255e-04  1.293827e-04
## ASV0237     -4.635378e-38 -2.914533e-04 -3.050765e-04 -3.192965e-04
## ASV11323    -5.277895e-38 -3.295087e-04 -3.447907e-04 -3.607485e-04
## ASV2232     -9.531958e-39 -5.722932e-05 -5.976065e-05 -6.240775e-05
## ASV0115     -1.712936e-38 -1.062857e-04 -1.112065e-04 -1.163135e-04
## ASV1171      8.978561e-39  5.014013e-05  5.220358e-05  5.432044e-05
## ASV1942      3.654010e-38  2.282310e-04  2.388342e-04  2.498954e-04
## ASV1889      3.873430e-39  2.303459e-05  2.404969e-05  2.510148e-05
## ASV0920      7.755445e-39  5.042277e-05  5.283401e-05  5.538044e-05
## ASV1805     -4.737769e-38 -2.929627e-04 -3.064761e-04 -3.205148e-04
## ASV1712      2.881460e-38  1.758411e-04  1.838435e-04  1.921369e-04
## ASV1458      4.287325e-38  2.583661e-04  2.703470e-04  2.824047e-04
## ASV1985      4.462910e-38  2.742112e-04  2.867868e-04  2.998383e-04
## ASV2960     -3.040027e-38 -1.761494e-04 -1.842262e-04 -1.920921e-04
## ASV5207     -1.049172e-38 -5.427013e-05 -5.670508e-05 -5.879026e-05
## ASV8548     -3.040027e-38 -1.761493e-04 -1.842092e-04 -1.920751e-04
## ASV0449     -1.610441e-38 -1.045381e-04 -1.093509e-04 -1.145895e-04
## ASV0609     -3.870970e-38 -2.373693e-04 -2.480153e-04 -2.592600e-04
## ASV1038      1.579448e-38  9.187298e-05  9.578931e-05  9.987895e-05
## ASV1145     -9.789054e-39 -5.548431e-05 -5.790054e-05 -6.029985e-05
## ASV15767    -3.040027e-38 -1.761492e-04 -1.842048e-04 -1.920716e-04
## ASV1630      4.151871e-38  2.476836e-04  2.590746e-04  2.705073e-04
## ASV1911      4.951350e-38  3.076403e-04  3.218676e-04  3.366861e-04
## ASV1950      3.783749e-38  2.235603e-04  2.338146e-04  2.440262e-04
## ASV2583      3.040027e-38  1.761490e-04  1.841585e-04  1.920234e-04
## ASV2853     -4.291496e-38 -2.575926e-04 -2.693955e-04 -2.813587e-04
## ASV2948      3.040027e-38  1.761488e-04  1.841310e-04  1.919947e-04
## ASV3116     -4.736171e-38 -2.812277e-04 -2.939794e-04 -3.068783e-04
## ASV3160     -2.650559e-38 -1.517231e-04 -1.585359e-04 -1.652089e-04
## ASV3354      2.960353e-38  1.849327e-04  1.934508e-04  2.023940e-04
## ASV3368      3.040027e-38  1.761486e-04  1.840927e-04  1.919549e-04
## ASV3464     -3.040027e-38 -1.761485e-04 -1.840793e-04 -1.919411e-04
## ASV3577      3.040027e-38  1.761484e-04  1.840660e-04  1.919273e-04
## ASV3746      3.890034e-38  2.300827e-04  2.404311e-04  2.509283e-04
## ASV3942      1.097022e-38  7.473062e-05  7.840444e-05  8.234226e-05
## ASV4000      3.040027e-38  1.761483e-04  1.840441e-04  1.919043e-04
## ASV4207      4.936724e-38  3.119637e-04  3.266051e-04  3.419091e-04
## ASV4261      3.040027e-38  1.761482e-04  1.840325e-04  1.918923e-04
## ASV4466      8.465270e-39  6.272218e-05  6.585510e-05  6.937332e-05
## ASV4487     -3.040027e-38 -1.761481e-04 -1.840230e-04 -1.918829e-04
## ASV4572     -2.258842e-38 -1.329785e-04 -1.390615e-04 -1.451164e-04
## ASV4718      3.040027e-38  1.761479e-04  1.840011e-04  1.918600e-04
## ASV4757     -3.040027e-38 -1.761478e-04 -1.839879e-04 -1.918462e-04
## ASV4929     -3.040027e-38 -1.761477e-04 -1.839748e-04 -1.918323e-04
## ASV5611     -3.040027e-38 -1.761477e-04 -1.839616e-04 -1.918185e-04
## ASV5614     -3.040027e-38 -1.761476e-04 -1.839485e-04 -1.918047e-04
## ASV5898      2.504378e-38  1.519191e-04  1.587267e-04  1.658419e-04
## ASV7627     -7.966931e-39 -3.923632e-05 -4.076888e-05 -4.215458e-05
## ASV3105     -1.724925e-38 -9.717364e-05 -1.014166e-04 -1.056119e-04
## ASV4762     -4.289539e-38 -2.577678e-04 -2.694261e-04 -2.814054e-04
## ASV5622      3.040027e-38  1.761473e-04  1.839151e-04  1.917695e-04
## ASV7129      3.728348e-38  2.277817e-04  2.381587e-04  2.489299e-04
## ASV12138    -3.040027e-38 -1.761472e-04 -1.838974e-04 -1.917507e-04
## ASV1687     -4.283297e-38 -2.610681e-04 -2.730121e-04 -2.853508e-04
## ASV2187      2.278210e-38  1.308611e-04  1.365908e-04  1.423675e-04
## ASV2204      4.347622e-38  2.646242e-04  2.765431e-04  2.889873e-04
## ASV2914      3.508626e-38  2.057955e-04  2.149060e-04  2.242116e-04
## ASV3297     -3.040027e-38 -1.761469e-04 -1.838504e-04 -1.917005e-04
## ASV3310     -3.816497e-38 -2.256207e-04 -2.356465e-04 -2.459396e-04
## ASV3677      2.298936e-40  1.184277e-05  1.277787e-05  1.386708e-05
## ASV4508      3.040027e-38  1.761467e-04  1.838226e-04  1.916708e-04
## ASV6236     -1.593537e-38 -8.649407e-05 -9.001954e-05 -9.356065e-05
## ASV6285      3.040027e-38  1.761466e-04  1.838043e-04  1.916513e-04
## ASV7576     -3.040027e-38 -1.761465e-04 -1.837914e-04 -1.916375e-04
## ASV7917     -3.040027e-38 -1.761464e-04 -1.837786e-04 -1.916237e-04
## ASV9353     -3.040027e-38 -1.761463e-04 -1.837658e-04 -1.916099e-04
## ASV1656      4.798970e-38  2.903588e-04  3.033586e-04  3.169308e-04
## ASV0280     -4.339101e-38 -2.741662e-04 -2.870461e-04 -3.005009e-04
## ASV4747     -1.331073e-41  4.189617e-06  4.482768e-06  4.913869e-06
## ASV2108     -5.359446e-38 -3.364519e-04 -3.522661e-04 -3.686721e-04
## ASV0885      1.812532e-38  1.130426e-04  1.182124e-04  1.236755e-04
## ASV2538     -1.526049e-38 -9.221747e-05 -9.633473e-05 -1.006341e-04
## ASV0968      3.382676e-38  2.083374e-04  2.180551e-04  2.280026e-04
## ASV1229     -3.040027e-38 -1.872186e-04 -1.959140e-04 -2.048459e-04
## ASV13306    -3.040027e-38 -1.872186e-04 -1.958993e-04 -2.048301e-04
## ASV13952     1.945637e-38  1.152503e-04  1.202598e-04  1.255096e-04
## ASV14631     1.562039e-38  1.030440e-04  1.080275e-04  1.133178e-04
## ASV2119      3.764688e-38  2.228659e-04  2.326490e-04  2.427975e-04
## ASV2450      3.124035e-38  1.948286e-04  2.038036e-04  2.132239e-04
## ASV2656     -3.040027e-38 -1.872186e-04 -1.958932e-04 -2.048238e-04
## ASV2942     -2.301131e-39 -1.362149e-05 -1.427558e-05 -1.489746e-05
## ASV3302      2.742672e-38  1.672455e-04  1.749264e-04  1.828162e-04
## ASV6515      1.137735e-38  6.524617e-05  6.796388e-05  7.081758e-05
## ASV6674     -3.040027e-38 -1.872186e-04 -1.958811e-04 -2.048109e-04
## ASV7296     -1.094069e-38 -6.908647e-05 -7.237505e-05 -7.576178e-05
## ASV7903      1.738022e-38  1.034712e-04  1.079785e-04  1.127219e-04
## ASV7943     -3.040027e-38 -1.872186e-04 -1.958658e-04 -2.047944e-04
## ASV8864      2.437797e-38  1.395754e-04  1.454110e-04  1.515022e-04
## ASV9389      4.228958e-39  1.879284e-05  1.923089e-05  1.973785e-05
## ASV9869     -3.040027e-38 -1.872186e-04 -1.958557e-04 -2.047835e-04
## ASV1051      3.040027e-38  1.872186e-04  1.958411e-04  2.047677e-04
## ASV13035    -1.540383e-39 -8.386023e-06 -8.760015e-06 -9.102940e-06
## ASV15744    -1.090322e-40  4.294672e-06  4.691443e-06  5.169661e-06
## ASV2526      3.821323e-39  2.032603e-05  2.106486e-05  2.186400e-05
## ASV1156      1.611748e-38  9.823857e-05  1.026215e-04  1.072468e-04
## ASV13562    -3.040027e-38 -1.872186e-04 -1.958325e-04 -2.047587e-04
## ASV1438      2.593136e-38  1.632678e-04  1.708854e-04  1.788696e-04
## ASV2268     -3.040027e-38 -1.872186e-04 -1.958249e-04 -2.047505e-04
## ASV2797      1.390718e-38  8.938751e-05  9.363221e-05  9.809971e-05
## ASV3744      3.326655e-38  2.082468e-04  2.179017e-04  2.280049e-04
## ASV8076     -3.270340e-38 -2.016943e-04 -2.109717e-04 -2.206024e-04
## ASV7055      1.304288e-38  8.573386e-05  8.992546e-05  9.431274e-05
## ASV7493     -2.756429e-38 -1.707622e-04 -1.787036e-04 -1.869047e-04
## ASV1201      6.774573e-38  4.161725e-04  4.352727e-04  4.550694e-04
## ASV5736     -5.758250e-38 -3.593149e-04 -3.759769e-04 -3.933602e-04
## ASV0558      2.739951e-38  1.734823e-04  1.816549e-04  1.901780e-04
## ASV14399    -4.069046e-38 -2.496102e-04 -2.610126e-04 -2.728660e-04
## ASV2992     -2.339360e-39 -1.416567e-05 -1.478682e-05 -1.544723e-05
## ASV4303     -2.976416e-38 -1.832659e-04 -1.916738e-04 -2.004078e-04
## ASV0565     -3.365717e-38 -2.084965e-04 -2.181042e-04 -2.281200e-04
## ASV0977     -5.261467e-38 -3.126451e-04 -3.263970e-04 -3.407237e-04
## ASV0140      2.546252e-38  1.565631e-04  1.638569e-04  1.713191e-04
## ASV14421    -3.040027e-38 -1.877511e-04 -1.964971e-04 -2.054878e-04
## ASV16909    -6.451075e-39 -4.148159e-05 -4.353518e-05 -4.561340e-05
## ASV3762     -3.040027e-38 -1.877511e-04 -1.964795e-04 -2.054689e-04
## ASV7141     -3.040027e-38 -1.877511e-04 -1.964647e-04 -2.054530e-04
## ASV3291      4.748886e-38  2.977925e-04  3.117067e-04  3.261996e-04
## ASV10440    -3.040027e-38 -1.877511e-04 -1.964477e-04 -2.054345e-04
## ASV10802     9.417493e-39  5.746902e-05  6.003369e-05  6.274165e-05
## ASV1698      4.746417e-39  3.112965e-05  3.258691e-05  3.417182e-05
## ASV2121      3.040027e-38  1.877511e-04  1.964367e-04  2.054227e-04
## ASV3549     -4.279005e-38 -2.650881e-04 -2.773144e-04 -2.900373e-04
## ASV6379      3.677931e-38  2.225829e-04  2.325748e-04  2.429796e-04
## ASV6824     -3.040027e-38 -1.877511e-04 -1.964044e-04 -2.053875e-04
## ASV8254      2.877942e-39  1.930414e-05  2.024266e-05  2.124766e-05
## ASV9951      1.288762e-38  8.227718e-05  8.614090e-05  9.021974e-05
## ASV1515     -1.325853e-38 -7.904900e-05 -8.256602e-05 -8.619237e-05
## ASV4327      9.254372e-39  5.731058e-05  5.990621e-05  6.265412e-05
## ASV0341     -1.357087e-38 -8.671636e-05 -9.082761e-05 -9.513186e-05
## ASV5562     -2.412252e-38 -1.527544e-04 -1.599334e-04 -1.674482e-04
## ASV1412      6.767584e-38  4.201901e-04  4.396075e-04  4.598366e-04
## ASV0154     -5.391687e-38 -3.376522e-04 -3.533809e-04 -3.697903e-04
## ASV3163     -2.556213e-38 -1.567666e-04 -1.639344e-04 -1.713815e-04
## ASV1782     -4.025381e-38 -2.494899e-04 -2.609656e-04 -2.729380e-04
## ASV3993     -4.863140e-39 -2.741528e-05 -2.860255e-05 -2.977603e-05
## ASV3164      1.996896e-38  1.205963e-04  1.259348e-04  1.315465e-04
## ASV1024      2.056696e-39  1.485545e-05  1.568888e-05  1.652481e-05
## ASV0771     -5.626077e-38 -3.421347e-04 -3.575670e-04 -3.736414e-04
## ASV2223     -2.335779e-38 -1.501806e-04 -1.573477e-04 -1.648403e-04
## ASV1638      9.199732e-38  5.650340e-04  5.908374e-04  6.176987e-04
## ASV0232     -2.690318e-38 -1.657767e-04 -1.733601e-04 -1.812697e-04
## ASV6771     -2.883570e-38 -1.826630e-04 -1.913977e-04 -2.003840e-04
## ASV4243     -1.246675e-38 -7.278107e-05 -7.594039e-05 -7.921868e-05
## ASV0162     -5.455773e-38 -3.381678e-04 -3.537863e-04 -3.700166e-04
## ASV0049      3.725044e-39  2.330448e-05  2.440880e-05  2.554330e-05
## ASV4697     -3.040027e-38 -1.885197e-04 -1.972508e-04 -2.063126e-04
## ASV12326     1.025350e-38  6.056248e-05  6.322546e-05  6.597473e-05
## ASV12586    -3.040027e-38 -1.885197e-04 -1.972384e-04 -2.062991e-04
## ASV1879      2.400915e-38  1.492064e-04  1.561267e-04  1.633125e-04
## ASV2864      6.571510e-38  4.109978e-04  4.301091e-04  4.500490e-04
## ASV3111     -1.774514e-38 -1.096790e-04 -1.147406e-04 -1.199933e-04
## ASV5633     -1.712650e-38 -1.053262e-04 -1.101555e-04 -1.151703e-04
## ASV5864      1.157740e-38  6.489453e-05  6.759282e-05  7.034763e-05
## ASV6364      1.407538e-38  9.021596e-05  9.451297e-05  9.900945e-05
## ASV1598      1.872054e-38  1.163842e-04  1.217341e-04  1.273486e-04
## ASV2649     -1.043700e-38 -6.870681e-05 -7.206754e-05 -7.558495e-05
## ASV4664      2.562370e-38  1.557171e-04  1.627113e-04  1.700259e-04
## ASV2654      4.234179e-38  2.616071e-04  2.736195e-04  2.861354e-04
## ASV6636     -2.018176e-39 -1.743894e-05 -1.849033e-05 -1.958542e-05
## ASV3334      3.044128e-38  1.941038e-04  2.032174e-04  2.128255e-04
## ASV0046     -5.457316e-38 -3.460956e-04 -3.623844e-04 -3.794294e-04
## ASV0661      5.768901e-38  3.522135e-04  3.682115e-04  3.848477e-04
## ASV0774      2.536083e-38  1.577446e-04  1.649943e-04  1.725925e-04
## ASV3815      3.076857e-38  1.888117e-04  1.974224e-04  2.063859e-04
## ASV0575      3.177497e-38  1.908170e-04  1.993432e-04  2.081907e-04
## ASV1953     -4.234295e-38 -2.624900e-04 -2.746136e-04 -2.872187e-04
## ASV0610      1.317110e-38  7.929158e-05  8.299858e-05  8.669662e-05
## ASV0245     -1.536988e-38 -9.581752e-05 -1.002526e-04 -1.048840e-04
## ASV3805     -2.469840e-38 -1.404729e-04 -1.464188e-04 -1.525294e-04
## ASV1182      6.198618e-38  3.909835e-04  4.092039e-04  4.283459e-04
## ASV1941     -1.053244e-53  7.998062e-07  8.789480e-07  9.631801e-07
## ASV0080     -7.465377e-38 -4.612773e-04 -4.823802e-04 -5.044451e-04
## ASV1033      2.218680e-38  1.376599e-04  1.440093e-04  1.506284e-04
## ASV5330     -2.696718e-38 -1.654887e-04 -1.732846e-04 -1.811585e-04
## ASV9702     -4.296794e-38 -2.547269e-04 -2.661158e-04 -2.777721e-04
## ASV0358      1.539547e-39  7.152983e-06  7.363360e-06  7.576182e-06
## ASV2225      2.129628e-38  1.310271e-04  1.369992e-04  1.432359e-04
## ASV2606      1.370983e-39  6.313574e-06  6.506393e-06  6.688820e-06
## ASV3510     -3.287515e-38 -2.038272e-04 -2.132088e-04 -2.229995e-04
## ASV3069      1.218600e-38  7.053803e-05  7.355026e-05  7.668391e-05
## ASV3849      2.098387e-38  1.270692e-04  1.327740e-04  1.387127e-04
## ASV1810     -5.357440e-38 -3.204176e-04 -3.346484e-04 -3.494437e-04
## ASV2046      7.494635e-38  4.674087e-04  4.891181e-04  5.117212e-04
## ASV2451     -8.175374e-39 -5.584003e-05 -5.872834e-05 -6.168666e-05
## ASV4047      3.969876e-38  2.446556e-04  2.558134e-04  2.674875e-04
## ASV7402     -3.040027e-38 -1.923314e-04 -2.014830e-04 -2.109300e-04
## ASV8250      3.759591e-38  2.364646e-04  2.474832e-04  2.590239e-04
## ASV3468      3.307445e-38  2.037500e-04  2.130516e-04  2.227689e-04
## ASV3521      6.727842e-38  4.183210e-04  4.376467e-04  4.578104e-04
## ASV6363     -2.217174e-38 -1.414624e-04 -1.482576e-04 -1.552681e-04
## ASV6444      1.488326e-38  9.475712e-05  9.916270e-05  1.038529e-04
## ASV8231      1.808446e-38  1.102774e-04  1.152593e-04  1.204614e-04
## ASV0196     -1.017205e-37 -6.276319e-04 -6.564359e-04 -6.864291e-04
## ASV12801    -3.040027e-38 -1.923315e-04 -2.014903e-04 -2.109384e-04
## ASV12906    -3.040027e-38 -1.923315e-04 -2.014748e-04 -2.109217e-04
## ASV13040    -3.040027e-38 -1.923315e-04 -2.014593e-04 -2.109049e-04
## ASV1313     -2.374210e-39 -1.893803e-05 -2.002594e-05 -2.116128e-05
## ASV14008     8.226650e-39  5.402413e-05  5.660252e-05  5.937026e-05
## ASV1546      1.291952e-38  7.521898e-05  7.844996e-05  8.180452e-05
## ASV1637      5.856290e-38  3.624426e-04  3.791887e-04  3.965670e-04
## ASV17076     2.607171e-38  1.579720e-04  1.650558e-04  1.724456e-04
## ASV2061      8.845169e-38  5.405643e-04  5.651101e-04  5.906629e-04
## ASV2177      3.483571e-38  2.218697e-04  2.323633e-04  2.433425e-04
## ASV2943      5.337967e-38  3.286892e-04  3.437916e-04  3.594599e-04
## ASV3020      4.738565e-38  2.900538e-04  3.032469e-04  3.169797e-04
## ASV30254     3.196384e-39  1.500926e-05  1.541767e-05  1.588383e-05
## ASV3219      6.639039e-38  4.069113e-04  4.254257e-04  4.447222e-04
## ASV3352      5.688884e-38  3.545029e-04  3.709025e-04  3.880320e-04
## ASV3355      2.395848e-38  1.516701e-04  1.588735e-04  1.663248e-04
## ASV3377      4.426499e-38  2.754518e-04  2.881684e-04  3.014596e-04
## ASV3449      2.679313e-38  1.612507e-04  1.684320e-04  1.759183e-04
## ASV3893      3.040027e-38  1.923315e-04  2.014427e-04  2.108872e-04
## ASV4326      1.920208e-38  1.140547e-04  1.190362e-04  1.242475e-04
## ASV5016     -3.040027e-38 -1.923315e-04 -2.014319e-04 -2.108754e-04
## ASV5152      2.590729e-38  1.516365e-04  1.581860e-04  1.649935e-04
## ASV5666     -6.417701e-40 -6.917332e-06 -7.422931e-06 -7.910079e-06
## ASV5802     -3.120044e-38 -1.971133e-04 -2.064103e-04 -2.160731e-04
## ASV6070      2.293484e-38  1.379368e-04  1.441068e-04  1.505075e-04
## ASV6488      1.946783e-38  1.194304e-04  1.248421e-04  1.305094e-04
## ASV6562     -3.040027e-38 -1.923315e-04 -2.014066e-04 -2.108480e-04
## ASV6930      2.350916e-38  1.415457e-04  1.478770e-04  1.544528e-04
## ASV7243      4.189974e-38  2.557308e-04  2.673270e-04  2.793958e-04
## ASV7506      2.687935e-38  1.627575e-04  1.700722e-04  1.776825e-04
## ASV7553     -3.040027e-38 -1.923315e-04 -2.013953e-04 -2.108356e-04
## ASV8064      1.822989e-38  1.105705e-04  1.155371e-04  1.207138e-04
## ASV8434     -1.653849e-38 -1.066008e-04 -1.117210e-04 -1.170547e-04
## ASV8858     -3.040027e-38 -1.923315e-04 -2.013767e-04 -2.108153e-04
## ASV2600      1.748986e-38  1.106879e-04  1.158927e-04  1.213239e-04
## ASV3398      6.696859e-38  4.174286e-04  4.367484e-04  4.569247e-04
## ASV4584     -3.040027e-38 -1.923315e-04 -2.013543e-04 -2.107908e-04
## ASV4864      3.422318e-38  2.115136e-04  2.211929e-04  2.313162e-04
## ASV0082     -1.333591e-37 -8.256505e-04 -8.636055e-04 -9.032077e-04
## ASV9626      2.739491e-38  1.705128e-04  1.782886e-04  1.865042e-04
## ASV1617      1.316185e-38  7.551635e-05  7.867092e-05  8.197510e-05
## ASV2765     -6.442546e-39 -4.344956e-05 -4.569756e-05 -4.797373e-05
## ASV2167     -4.147505e-38 -2.565041e-04 -2.682531e-04 -2.805376e-04
## ASV1628      2.796254e-38  1.638933e-04  1.709436e-04  1.783190e-04
## ASV3260     -6.997128e-39 -4.095827e-05 -4.278322e-05 -4.462361e-05
## ASV3645      3.141325e-39  2.338159e-05  2.451529e-05  2.582178e-05
## ASV6057     -3.956546e-38 -2.447262e-04 -2.559713e-04 -2.676972e-04
## ASV0662     -5.668642e-39 -3.298996e-05 -3.440614e-05 -3.587682e-05
## ASV4267     -4.740777e-39 -3.099248e-05 -3.254683e-05 -3.412001e-05
## ASV1070      4.123518e-38  2.606247e-04  2.728527e-04  2.856466e-04
## ASV0633     -1.133285e-38 -6.802064e-05 -7.106292e-05 -7.421256e-05
## ASV0333      4.292369e-38  2.679762e-04  2.803921e-04  2.933700e-04
## ASV0966      3.269203e-38  2.038554e-04  2.132246e-04  2.230696e-04
## ASV1848      4.620204e-38  2.930367e-04  3.068254e-04  3.212621e-04
## ASV13390    -3.040027e-38 -1.874130e-04 -1.960749e-04 -2.050258e-04
## ASV14901    -3.040027e-38 -1.874130e-04 -1.960602e-04 -2.050099e-04
## ASV1676     -3.575227e-38 -2.162113e-04 -2.259085e-04 -2.360020e-04
## ASV1756     -3.698453e-39 -2.263726e-05 -2.368596e-05 -2.475745e-05
## ASV22537    -4.467302e-39 -2.610804e-05 -2.729454e-05 -2.846886e-05
## ASV3303     -2.381323e-40 -2.829267e-06 -3.082484e-06 -3.291225e-06
## ASV4030     -1.291460e-38 -7.842669e-05 -8.201992e-05 -8.570299e-05
## ASV4871      2.388270e-38  1.495826e-04  1.564909e-04  1.637565e-04
## ASV5536      1.504228e-39  9.314311e-06  9.691860e-06  1.013705e-05
## ASV5700      1.081935e-38  6.711240e-05  7.014893e-05  7.336706e-05
## ASV8957      2.173704e-38  1.256629e-04  1.309829e-04  1.365367e-04
## ASV11210     1.823941e-38  1.188673e-04  1.245885e-04  1.306137e-04
## ASV7585     -3.040027e-38 -1.874130e-04 -1.960541e-04 -2.050039e-04
## ASV8596     -3.040027e-38 -1.874130e-04 -1.960395e-04 -2.049880e-04
## ASV9532     -1.249619e-38 -7.547227e-05 -7.889242e-05 -8.241249e-05
## ASV4254      2.156558e-38  1.354143e-04  1.416887e-04  1.482820e-04
## ASV13299    -3.040027e-38 -1.874130e-04 -1.960264e-04 -2.049739e-04
## ASV15627    -3.040027e-38 -1.874130e-04 -1.960119e-04 -2.049580e-04
## ASV6302     -2.623933e-38 -1.507251e-04 -1.571242e-04 -1.637604e-04
## ASV3040      1.210613e-38  7.535094e-05  7.879265e-05  8.242329e-05
## ASV0632      2.456671e-38  1.532652e-04  1.603883e-04  1.678082e-04
## ASV3694      3.937979e-38  2.440474e-04  2.552869e-04  2.670042e-04
## ASV1592     -8.225889e-39 -4.632693e-05 -4.825360e-05 -5.023747e-05
## ASV0538      1.956246e-38  1.239503e-04  1.298167e-04  1.359266e-04
## ASV0832      4.413547e-38  2.727480e-04  2.852434e-04  2.982982e-04
## ASV0727      3.240024e-38  2.052579e-04  2.149250e-04  2.250274e-04
## ASV1165     -4.243174e-38 -2.643507e-04 -2.765874e-04 -2.893588e-04
## ASV1325      2.978504e-39  2.803269e-05  2.978115e-05  3.165208e-05
## ASV0819      7.624776e-38  4.744835e-04  4.963932e-04  5.192866e-04
## ASV2251      4.388158e-38  2.566459e-04  2.677100e-04  2.792199e-04
## ASV0100     -2.715520e-39 -1.638220e-05 -1.710137e-05 -1.786046e-05
## ASV0444     -2.034690e-38 -1.265031e-04 -1.323313e-04 -1.384380e-04
## ASV0800      1.023374e-37  6.220546e-04  6.500667e-04  6.792950e-04
## ASV2432      3.064522e-39  1.474125e-05  1.520939e-05  1.569978e-05
## ASV2883      3.277645e-39  1.773516e-05  1.842055e-05  1.913062e-05
## ASV3894      4.022887e-39  2.041883e-05  2.113385e-05  2.186825e-05
## ASV2367      7.032013e-38  4.341136e-04  4.539856e-04  4.747399e-04
## ASV3724     -4.210973e-38 -2.582322e-04 -2.701207e-04 -2.823838e-04
## ASV2112     -3.529808e-38 -2.200352e-04 -2.302050e-04 -2.408335e-04
## ASV3661      1.197793e-38  7.595683e-05  7.953518e-05  8.327809e-05
## ASV2096     -2.484148e-38 -1.587756e-04 -1.662946e-04 -1.741611e-04
## ASV3551     -3.048313e-38 -1.851950e-04 -1.935215e-04 -2.022020e-04
## ASV11343    -6.929173e-40 -5.980268e-06 -6.354878e-06 -6.737031e-06
## ASV2051      2.522410e-38  1.579755e-04  1.653165e-04  1.730052e-04
## ASV2617     -3.522060e-38 -2.174484e-04 -2.274342e-04 -2.378318e-04
## ASV0125     -1.539783e-38 -9.611700e-05 -1.005737e-04 -1.052210e-04
## ASV0372      5.367925e-38  3.314375e-04  3.466241e-04  3.624712e-04
## ASV6751     -4.053261e-38 -2.478039e-04 -2.592502e-04 -2.709846e-04
## ASV10810     8.931547e-39  5.541104e-05  5.795288e-05  6.062211e-05
## ASV0461     -2.242560e-38 -1.410224e-04 -1.476074e-04 -1.544898e-04
## ASV1945     -1.310297e-38 -8.348082e-05 -8.743520e-05 -9.156809e-05
## ASV0882     -1.037686e-38 -7.075338e-05 -7.431636e-05 -7.805969e-05
## ASV4040     -5.769967e-39 -3.599195e-05 -3.766859e-05 -3.940140e-05
## ASV0109     -4.721853e-40 -2.523926e-06 -2.615547e-06 -2.712550e-06
## ASV0174      1.933194e-38  1.123340e-04  1.171656e-04  1.221543e-04
## ASV2851      3.199151e-38  1.914681e-04  1.999223e-04  2.087413e-04
## ASV5312      5.312496e-39  3.226341e-05  3.372442e-05  3.525441e-05
## ASV9402     -4.325222e-38 -2.656962e-04 -2.777873e-04 -2.904149e-04
## ASV4870     -3.516589e-38 -2.146671e-04 -2.245437e-04 -2.346891e-04
## ASV0589      4.139692e-38  2.562793e-04  2.680571e-04  2.803480e-04
## ASV1221     -8.777030e-54  5.280853e-07  5.767836e-07  6.286130e-07
## ASV6028     -4.018858e-38 -2.480878e-04 -2.594367e-04 -2.712985e-04
## ASV5106     -1.554329e-38 -9.367488e-05 -9.786305e-05 -1.022199e-04
## ASV4977     -4.326786e-39 -3.279587e-05 -3.459671e-05 -3.648893e-05
## ASV5715     -2.635914e-38 -1.629537e-04 -1.704258e-04 -1.782295e-04
## ASV4182      9.114300e-39  6.084561e-05  6.386204e-05  6.702635e-05
## ASV2383     -1.224025e-39 -1.270653e-05 -1.354493e-05 -1.444057e-05
## ASV3985      4.632261e-38  2.918889e-04  3.055420e-04  3.198213e-04
## ASV2787     -3.657967e-38 -2.204714e-04 -2.305185e-04 -2.407968e-04
## ASV6756     -3.021509e-38 -1.888915e-04 -1.977458e-04 -2.069067e-04
## ASV1634     -4.979796e-38 -3.034941e-04 -3.171843e-04 -3.314799e-04
## ASV0649     -1.484206e-38 -9.262162e-05 -9.692184e-05 -1.014001e-04
## ASV1591     -2.369798e-53 -5.085902e-06 -5.563884e-06 -6.070546e-06
## ASV1854      4.958603e-38  3.134453e-04  3.281545e-04  3.435369e-04
## ASV4205      3.306676e-38  2.090174e-04  2.188216e-04  2.290794e-04
## ASV3293     -1.995820e-38 -1.214188e-04 -1.268846e-04 -1.325933e-04
## ASV1631      2.297533e-38  1.423953e-04  1.489281e-04  1.557697e-04
## ASV1747     -1.242790e-38 -8.049638e-05 -8.436975e-05 -8.842410e-05
## ASV5634      1.045123e-38  6.457672e-05  6.748993e-05  7.058017e-05
## ASV0965     -1.657955e-38 -1.017126e-04 -1.063348e-04 -1.111647e-04
## ASV1094      2.858736e-38  1.754833e-04  1.834833e-04  1.918233e-04
## ASV2744     -1.141014e-53 -5.183182e-06 -5.668809e-06 -6.184766e-06
## ASV7212     -4.215240e-38 -2.651084e-04 -2.774777e-04 -2.904052e-04
## ASV0344     -2.838384e-38 -1.759738e-04 -1.840707e-04 -1.925248e-04
## ASV11812    -3.040027e-38 -1.902559e-04 -1.991710e-04 -2.084081e-04
## ASV7867     -4.133840e-39 -2.735272e-05 -2.875550e-05 -3.016356e-05
## ASV6670      2.913185e-38  1.739218e-04  1.815887e-04  1.895955e-04
## ASV10991     1.901303e-39  4.282246e-06  4.070833e-06  3.875438e-06
## ASV1281      5.335600e-38  3.394320e-04  3.554512e-04  3.722246e-04
## ASV12845    -3.040027e-38 -1.902560e-04 -1.991580e-04 -2.083940e-04
## ASV1833     -3.040027e-38 -1.902560e-04 -1.991429e-04 -2.083776e-04
## ASV2211      2.086413e-38  1.244988e-04  1.299561e-04  1.356765e-04
## ASV3920      4.418922e-38  2.690319e-04  2.811459e-04  2.937978e-04
## ASV4545     -3.448612e-38 -2.161412e-04 -2.262371e-04 -2.367448e-04
## ASV4710     -3.774718e-38 -2.360865e-04 -2.470721e-04 -2.585213e-04
## ASV4978      5.969515e-39  3.759960e-05  3.933642e-05  4.117330e-05
## ASV9630     -9.827452e-40 -6.547209e-06 -6.887962e-06 -7.227387e-06
## ASV9797     -2.502353e-40 -6.088039e-06 -6.609903e-06 -7.146665e-06
## ASV13469    -3.040027e-38 -1.902560e-04 -1.991028e-04 -2.083339e-04
## ASV14961    -1.112200e-38 -6.945500e-05 -7.268035e-05 -7.604133e-05
## ASV6259      1.778413e-38  1.073677e-04  1.121546e-04  1.171544e-04
## ASV6294     -2.162499e-38 -1.354590e-04 -1.417561e-04 -1.483331e-04
## ASV6883     -9.828994e-39 -6.326825e-05 -6.629059e-05 -6.945172e-05
## ASV7041     -2.462302e-38 -1.568967e-04 -1.643071e-04 -1.720637e-04
## ASV4363     -3.040027e-38 -1.849001e-04 -1.934240e-04 -2.021310e-04
## ASV1784     -4.345424e-38 -2.690979e-04 -2.815453e-04 -2.944625e-04
## ASV2140      3.696063e-39  2.398900e-05  2.499772e-05  2.618976e-05
## ASV3202      3.040027e-38  1.849001e-04  1.934005e-04  2.021059e-04
## ASV6017     -3.040027e-38 -1.849001e-04 -1.933862e-04 -2.020905e-04
## ASV9129      1.550687e-38  9.325929e-05  9.734452e-05  1.016606e-04
## ASV0917      3.114227e-38  1.896477e-04  1.983474e-04  2.072871e-04
## ASV10584    -1.190688e-39 -3.106852e-06 -3.148842e-06 -3.084124e-06
## ASV11218     2.001193e-38  1.206135e-04  1.259413e-04  1.315413e-04
## ASV11229     2.084112e-39  1.713119e-05  1.802123e-05  1.905442e-05
## ASV11604    -3.080520e-39 -2.084926e-05 -2.200884e-05 -2.311349e-05
## ASV2103     -3.538295e-38 -2.169844e-04 -2.269763e-04 -2.372863e-04
## ASV2165     -3.040027e-38 -1.849001e-04 -1.933455e-04 -2.020471e-04
## ASV2340      3.467578e-38  2.060139e-04  2.150650e-04  2.244844e-04
## ASV3738     -3.040027e-38 -1.849000e-04 -1.933288e-04 -2.020291e-04
## ASV4012      9.229818e-39  5.621445e-05  5.869138e-05  6.132987e-05
## ASV4094     -3.040027e-38 -1.849000e-04 -1.933168e-04 -2.020162e-04
## ASV4454     -3.040027e-38 -1.849000e-04 -1.933026e-04 -2.020007e-04
## ASV7031      6.628060e-39  4.344030e-05  4.550437e-05  4.771283e-05
## ASV7087     -1.213891e-38 -7.094942e-05 -7.406542e-05 -7.725328e-05
## ASV4159      1.911772e-39  1.101499e-05  1.142154e-05  1.189800e-05
## ASV5084     -3.040027e-38 -1.849000e-04 -1.932864e-04 -2.019833e-04
## ASV6584     -3.040027e-38 -1.849000e-04 -1.932723e-04 -2.019679e-04
## ASV9614     -3.040027e-38 -1.849000e-04 -1.932581e-04 -2.019525e-04
## ASV16068    -3.040027e-38 -1.848999e-04 -1.932440e-04 -2.019371e-04
## ASV2141     -4.170490e-38 -2.466569e-04 -2.574560e-04 -2.686997e-04
## ASV0395     -2.642619e-39 -1.726359e-05 -1.810118e-05 -1.898065e-05
## ASV5640     -6.567418e-39 -4.277969e-05 -4.484505e-05 -4.700632e-05
## ASV2854     -3.441828e-38 -2.080972e-04 -2.174134e-04 -2.271327e-04
## ASV3825     -5.932104e-38 -3.659099e-04 -3.826403e-04 -4.001197e-04
## ASV0481      6.628359e-38  3.997532e-04  4.175919e-04  4.362149e-04
## ASV3304      2.906600e-39  1.854120e-05  1.942008e-05  2.034120e-05
## ASV0445      3.962952e-38  2.428707e-04  2.538954e-04  2.654087e-04
## ASV1845     -2.009961e-38 -1.271652e-04 -1.331353e-04 -1.393782e-04
## ASV3110     -2.302631e-38 -1.407406e-04 -1.471169e-04 -1.537850e-04
##                                                                    
## (Intercept) -2.319684e-06 -2.697601e-06 -3.136104e-06 -3.644604e-06
## ASV1236      2.182917e-04  2.280817e-04  2.382815e-04  2.489060e-04
## ASV0421     -3.830610e-04 -4.001105e-04 -4.178649e-04 -4.363485e-04
## ASV0691     -3.302667e-04 -3.445119e-04 -3.593053e-04 -3.746621e-04
## ASV0899     -5.210495e-07 -1.526746e-07  2.653031e-07  7.376647e-07
## ASV1004      4.359075e-04  4.553409e-04  4.755797e-04  4.966518e-04
## ASV1041     -2.977163e-04 -3.111261e-04 -3.251037e-04 -3.396699e-04
## ASV1058      4.060670e-04  4.242214e-04  4.431340e-04  4.628316e-04
## ASV12542     1.230172e-04  1.283003e-04  1.337850e-04  1.394765e-04
## ASV1294      4.741660e-04  4.955945e-04  5.179381e-04  5.412311e-04
## ASV13113     1.671614e-04  1.748339e-04  1.828456e-04  1.912103e-04
## ASV1318      4.146359e-04  4.333194e-04  4.527948e-04  4.730915e-04
## ASV2269     -1.259508e-04 -1.317380e-04 -1.377790e-04 -1.440839e-04
## ASV2542      2.684095e-04  2.809602e-04  2.940858e-04  3.078117e-04
## ASV2660     -2.396987e-04 -2.504252e-04 -2.615986e-04 -2.732346e-04
## ASV2737     -1.610823e-05 -1.709064e-05 -1.813603e-05 -1.924865e-05
## ASV2840      3.116788e-04  3.252415e-04  3.393360e-04  3.539781e-04
## ASV3053      1.574659e-05  1.635976e-05  1.699213e-05  1.764380e-05
## ASV3077      9.807940e-05  1.024272e-04  1.069548e-04  1.116682e-04
## ASV3134      3.422426e-04  3.581599e-04  3.748007e-04  3.921961e-04
## ASV3140      1.534922e-04  1.607011e-04  1.682405e-04  1.761247e-04
## ASV3579      5.953427e-05  6.243551e-05  6.548196e-05  6.868106e-05
## ASV6119     -1.259295e-04 -1.317147e-04 -1.377535e-04 -1.440559e-04
## ASV7557     -1.259192e-04 -1.317034e-04 -1.377411e-04 -1.440425e-04
## ASV8422      6.398923e-05  6.659433e-05  6.928667e-05  7.206743e-05
## ASV1086     -3.311476e-05 -3.451474e-05 -3.596761e-05 -3.747477e-05
## ASV1310      2.327085e-04  2.431591e-04  2.540504e-04  2.653984e-04
## ASV15750    -6.112393e-05 -6.396011e-05 -6.692201e-05 -7.001470e-05
## ASV16905    -1.259139e-04 -1.316975e-04 -1.377347e-04 -1.440353e-04
## ASV2033      2.269755e-04  2.373029e-04  2.480785e-04  2.593197e-04
## ASV2089      8.680023e-05  9.082145e-05  9.502130e-05  9.940705e-05
## ASV2127      3.325033e-04  3.472551e-04  3.626116e-04  3.785931e-04
## ASV2725      3.777564e-04  3.943899e-04  4.116952e-04  4.296941e-04
## ASV2804     -1.259103e-04 -1.316935e-04 -1.377302e-04 -1.440304e-04
## ASV3075      2.382653e-04  2.488922e-04  2.599615e-04  2.714890e-04
## ASV3327      2.239430e-04  2.341905e-04  2.448886e-04  2.560555e-04
## ASV3342      2.489022e-04  2.604134e-04  2.724392e-04  2.850008e-04
## ASV3532     -2.234480e-04 -2.337091e-04 -2.444217e-04 -2.556036e-04
## ASV3600      2.788692e-04  2.914685e-04  3.046069e-04  3.183050e-04
## ASV4013      2.341051e-04  2.445241e-04  2.553739e-04  2.666693e-04
## ASV4136      2.359898e-04  2.465471e-04  2.575447e-04  2.689985e-04
## ASV4195      1.258945e-04  1.316762e-04  1.377113e-04  1.440097e-04
## ASV4407     -1.258842e-04 -1.316649e-04 -1.376989e-04 -1.439962e-04
## ASV4717      2.439400e-06  2.263318e-06  2.055778e-06  1.813577e-06
## ASV6794      1.223613e-04  1.275167e-04  1.328606e-04  1.383974e-04
## ASV8324     -1.258800e-04 -1.316603e-04 -1.376938e-04 -1.439904e-04
## ASV8981     -3.619920e-05 -3.784221e-05 -3.955418e-05 -4.133747e-05
## ASV9859      9.312318e-05  9.753908e-05  1.021644e-04  1.070089e-04
## ASV0936     -1.909995e-04 -1.995217e-04 -2.083994e-04 -2.176453e-04
## ASV12683    -2.285762e-05 -2.408837e-05 -2.538788e-05 -2.676008e-05
## ASV1293      2.835249e-04  2.961300e-04  3.092530e-04  3.229113e-04
## ASV13055    -3.272844e-05 -3.426895e-05 -3.587879e-05 -3.756073e-05
## ASV17063    -1.258612e-04 -1.316397e-04 -1.376713e-04 -1.439658e-04
## ASV2228      1.258509e-04  1.316284e-04  1.376589e-04  1.439524e-04
## ASV2769     -2.624090e-05 -2.745874e-05 -2.873004e-05 -3.005684e-05
## ASV2803      5.357652e-05  5.567301e-05  5.783156e-05  6.005219e-05
## ASV2896      1.515586e-04  1.583518e-04  1.654323e-04  1.728108e-04
## ASV3062      4.537112e-05  4.753060e-05  4.979347e-05  5.216469e-05
## ASV3107      1.842541e-04  1.925894e-04  2.012828e-04  2.103478e-04
## ASV3265      3.670591e-04  3.833001e-04  4.002029e-04  4.177892e-04
## ASV3666     -1.043790e-05 -1.101496e-05 -1.162473e-05 -1.226906e-05
## ASV4497      8.637092e-05  9.018864e-05  9.416343e-05  9.830078e-05
## ASV6914     -4.717457e-05 -4.951850e-05 -5.198000e-05 -5.456491e-05
## ASV0576     -4.319348e-04 -4.507332e-04 -4.702708e-04 -4.905697e-04
## ASV0673      1.160165e-04  1.215920e-04  1.274356e-04  1.335598e-04
## ASV0772      1.284531e-04  1.340952e-04  1.399653e-04  1.460708e-04
## ASV0862     -1.048332e-04 -1.093180e-04 -1.139726e-04 -1.188014e-04
## ASV0898      1.109390e-04  1.162319e-04  1.217754e-04  1.275811e-04
## ASV0910      2.395352e-04  2.508413e-04  2.626754e-04  2.750615e-04
## ASV0964     -1.568988e-04 -1.637997e-04 -1.709795e-04 -1.784473e-04
## ASV10059     1.099020e-04  1.150343e-04  1.204033e-04  1.260197e-04
## ASV10263    -1.259004e-04 -1.316823e-04 -1.377176e-04 -1.440163e-04
## ASV1088      1.262081e-04  1.321308e-04  1.383274e-04  1.448103e-04
## ASV1101      2.130047e-04  2.226314e-04  2.326694e-04  2.431343e-04
## ASV1183      1.405123e-04  1.470994e-04  1.539881e-04  1.611913e-04
## ASV11956     4.866853e-05  5.053205e-05  5.244656e-05  5.441160e-05
## ASV12774    -2.286932e-05 -2.414649e-05 -2.549865e-05 -2.693028e-05
## ASV1321      5.337510e-05  5.599344e-05  5.874303e-05  6.163056e-05
## ASV13793    -1.258867e-04 -1.316673e-04 -1.377011e-04 -1.439981e-04
## ASV14482    -1.468614e-05 -1.556304e-05 -1.649470e-05 -1.748452e-05
## ASV15483     8.261678e-05  8.624075e-05  9.001111e-05  9.393276e-05
## ASV2062      5.439753e-04  5.686629e-04  5.944148e-04  6.212718e-04
## ASV2132      2.435198e-04  2.545555e-04  2.660667e-04  2.780719e-04
## ASV2413      3.486350e-04  3.641590e-04  3.803267e-04  3.971607e-04
## ASV2490      2.305836e-04  2.407889e-04  2.514106e-04  2.624629e-04
## ASV2594      1.239246e-04  1.294222e-04  1.351476e-04  1.411093e-04
## ASV2822     -1.259008e-04 -1.316825e-04 -1.377177e-04 -1.440161e-04
## ASV2863      2.161760e-04  2.258938e-04  2.360209e-04  2.465720e-04
## ASV2910      2.745737e-04  2.865773e-04  2.990579e-04  3.120305e-04
## ASV2980      1.043596e-04  1.091493e-04  1.141482e-04  1.193645e-04
## ASV3307      1.258827e-04  1.316627e-04  1.376960e-04  1.439923e-04
## ASV3474      1.928365e-04  2.018587e-04  2.112962e-04  2.211675e-04
## ASV3502      3.976312e-04  4.155252e-04  4.341775e-04  4.536160e-04
## ASV4236      2.010881e-04  2.099144e-04  2.190949e-04  2.286408e-04
## ASV4842     -7.042209e-05 -7.375466e-05 -7.724110e-05 -8.088798e-05
## ASV4894     -1.258929e-04 -1.316738e-04 -1.377081e-04 -1.440055e-04
## ASV5290      1.499551e-04  1.567100e-04  1.637526e-04  1.710936e-04
## ASV5501      2.694885e-05  2.811383e-05  2.932575e-05  3.058633e-05
## ASV5795      9.959803e-05  1.041039e-04  1.088041e-04  1.137064e-04
## ASV5987     -1.258958e-04 -1.316770e-04 -1.377115e-04 -1.440093e-04
## ASV6267     -1.258855e-04 -1.316657e-04 -1.376992e-04 -1.439958e-04
## ASV6862      2.337131e-04  2.438409e-04  2.543634e-04  2.652920e-04
## ASV7145      4.023792e-05  4.182716e-05  4.346557e-05  4.515356e-05
## ASV7673     -1.258819e-04 -1.316617e-04 -1.376948e-04 -1.439909e-04
## ASV7789      4.202687e-05  4.401372e-05  4.609482e-05  4.827469e-05
## ASV7809     -1.848065e-05 -1.933905e-05 -2.023451e-05 -2.116828e-05
## ASV8002     -1.258732e-04 -1.316522e-04 -1.376844e-04 -1.439796e-04
## ASV8205      6.597208e-05  6.872000e-05  7.156571e-05  7.451130e-05
## ASV9155     -9.550971e-05 -9.990765e-05 -1.044989e-04 -1.092909e-04
## ASV9221     -2.022522e-05 -2.128453e-05 -2.240081e-05 -2.357710e-05
## ASV9311     -1.258575e-04 -1.316350e-04 -1.376655e-04 -1.439589e-04
## ASV9557     -1.258472e-04 -1.316238e-04 -1.376532e-04 -1.439454e-04
## ASV9936     -1.258369e-04 -1.316125e-04 -1.376409e-04 -1.439319e-04
## ASV1445      2.832820e-04  2.962423e-04  3.097714e-04  3.238922e-04
## ASV4232      2.369284e-04  2.477997e-04  2.591525e-04  2.710069e-04
## ASV6479     -2.458459e-06 -2.391291e-06 -2.302759e-06 -2.190094e-06
## ASV0142     -6.171050e-04 -6.443356e-04 -6.726708e-04 -7.021468e-04
## ASV0378     -2.029552e-04 -2.118412e-04 -2.210810e-04 -2.306854e-04
## ASV1122      3.729635e-04  3.899763e-04  4.077313e-04  4.262578e-04
## ASV0123     -6.049047e-04 -6.315983e-04 -6.593747e-04 -6.882696e-04
## ASV2064      6.015238e-05  6.261891e-05  6.517087e-05  6.781002e-05
## ASV4459     -7.104609e-05 -7.437216e-05 -7.784898e-05 -8.148277e-05
## ASV0448      1.125182e-04  1.181838e-04  1.241428e-04  1.304105e-04
## ASV0397      2.823977e-04  2.953441e-04  3.088587e-04  3.229640e-04
## ASV0485      3.920669e-04  4.097469e-04  4.281777e-04  4.473872e-04
## ASV1566      3.239275e-04  3.384711e-04  3.536281e-04  3.694211e-04
## ASV1365      2.085411e-04  2.178633e-04  2.275753e-04  2.376910e-04
## ASV1065      4.347431e-04  4.544840e-04  4.750755e-04  4.965500e-04
## ASV0722     -6.927010e-06 -7.103724e-06 -7.277438e-06 -7.447330e-06
## ASV12660    -2.082935e-04 -2.176633e-04 -2.274278e-04 -2.376012e-04
## ASV0223     -3.014279e-06 -2.897018e-06 -2.752447e-06 -2.577624e-06
## ASV0229      1.964505e-04  2.055547e-04  2.150674e-04  2.250056e-04
## ASV0877     -7.729602e-05 -8.075619e-05 -8.436001e-05 -8.811237e-05
## ASV0983      4.003367e-04  4.183208e-04  4.370620e-04  4.565876e-04
## ASV0626     -1.304188e-04 -1.358905e-04 -1.415573e-04 -1.474232e-04
## ASV4146     -2.489523e-05 -2.611080e-05 -2.738494e-05 -2.872026e-05
## ASV4175     -2.466988e-04 -2.579545e-04 -2.696989e-04 -2.819510e-04
## ASV2082     -1.405664e-05 -1.469089e-05 -1.535399e-05 -1.604742e-05
## ASV2272      1.755098e-04  1.835059e-04  1.918511e-04  2.005594e-04
## ASV2245     -2.140410e-04 -2.238144e-04 -2.340126e-04 -2.446521e-04
## ASV0590     -1.262572e-04 -1.321080e-04 -1.382230e-04 -1.446133e-04
## ASV0217     -1.926714e-04 -2.004020e-04 -2.083740e-04 -2.165887e-04
## ASV0416      2.006759e-04  2.094491e-04  2.185691e-04  2.280461e-04
## ASV1056      2.372542e-04  2.483487e-04  2.599514e-04  2.720847e-04
## ASV7777     -2.156313e-04 -2.256057e-04 -2.360259e-04 -2.469100e-04
## ASV0455      4.464943e-05  4.685355e-05  4.916723e-05  5.159574e-05
## ASV0604      4.892148e-05  5.152712e-05  5.428049e-05  5.719047e-05
## ASV6100     -2.004239e-04 -2.097752e-04 -2.195518e-04 -2.297718e-04
## ASV11359    -2.199797e-04 -2.299674e-04 -2.403840e-04 -2.512458e-04
## ASV6604      1.564005e-04  1.636790e-04  1.712894e-04  1.792463e-04
## ASV5004     -1.314766e-04 -1.375422e-04 -1.438766e-04 -1.504903e-04
## ASV1483     -1.200611e-04 -1.255684e-04 -1.313168e-04 -1.373159e-04
## ASV9773     -2.548936e-04 -2.666834e-04 -2.790003e-04 -2.918661e-04
## ASV4059      2.532799e-05  2.671508e-05  2.818540e-05  2.974449e-05
## ASV1193      4.089676e-04  4.276056e-04  4.470557e-04  4.673498e-04
## ASV4610     -3.795527e-05 -3.946309e-05 -4.101534e-05 -4.261174e-05
## ASV0742     -1.539368e-04 -1.605530e-04 -1.674204e-04 -1.745456e-04
## ASV1502     -2.473531e-06 -2.708671e-06 -2.963442e-06 -3.239217e-06
## ASV0195     -4.405599e-05 -4.620573e-05 -4.846244e-05 -5.083158e-05
## ASV1213      1.323947e-04  1.383292e-04  1.445118e-04  1.509512e-04
## ASV1648     -1.893023e-04 -1.980655e-04 -2.072212e-04 -2.167856e-04
## ASV6984     -1.402608e-04 -1.467138e-04 -1.534513e-04 -1.604847e-04
## ASV0396     -9.947357e-05 -1.031735e-04 -1.069609e-04 -1.108331e-04
## ASV4297      2.076864e-04  2.168104e-04  2.263015e-04  2.361717e-04
## ASV2622      4.750497e-04  4.961690e-04  5.181597e-04  5.410517e-04
## ASV3512      7.107573e-05  7.446321e-05  7.801330e-05  8.173396e-05
## ASV2411      1.649240e-04  1.726475e-04  1.807255e-04  1.891735e-04
## ASV2291     -3.744527e-05 -3.912270e-05 -4.087186e-05 -4.269563e-05
## ASV0807      1.971101e-04  2.066925e-04  2.167448e-04  2.272901e-04
## ASV1292      1.117384e-04  1.169088e-04  1.223108e-04  1.279537e-04
## ASV1035      5.036177e-05  5.250326e-05  5.472305e-05  5.702276e-05
## ASV0070     -1.138918e-04 -1.187632e-04 -1.238185e-04 -1.290624e-04
## ASV0255      4.412049e-05  4.601178e-05  4.797265e-05  5.000444e-05
## ASV0057     -4.890102e-04 -5.103964e-04 -5.326314e-04 -5.557412e-04
## ASV0077     -7.242739e-05 -7.544363e-05 -7.856678e-05 -8.179908e-05
## ASV0625      4.922102e-04  5.141885e-04  5.370812e-04  5.609203e-04
## ASV2464      2.407406e-04  2.514677e-04  2.626381e-04  2.742670e-04
## ASV1315      4.191005e-04  4.381828e-04  4.580960e-04  4.788731e-04
## ASV2673      3.133837e-04  3.280911e-04  3.434770e-04  3.595718e-04
## ASV2161      1.269694e-04  1.328668e-04  1.390322e-04  1.454772e-04
## ASV0337     -2.066330e-04 -2.160410e-04 -2.258584e-04 -2.361016e-04
## ASV7680     -2.414752e-04 -2.525038e-04 -2.640124e-04 -2.760198e-04
## ASV0611      5.216099e-04  5.454961e-04  5.704327e-04  5.964619e-04
## ASV3118     -1.791460e-04 -1.874075e-04 -1.960355e-04 -2.050449e-04
## ASV1284      1.949473e-04  2.041646e-04  2.138090e-04  2.238988e-04
## ASV0889      1.417984e-04  1.481130e-04  1.546900e-04  1.615385e-04
## ASV4649     -1.529504e-04 -1.600504e-04 -1.674700e-04 -1.752224e-04
## ASV1108     -1.943588e-04 -2.035645e-04 -2.132012e-04 -2.232883e-04
## ASV0738     -2.395171e-05 -2.421644e-05 -2.441782e-05 -2.454670e-05
## ASV0473      3.038503e-05  3.180966e-05  3.329924e-05  3.485651e-05
## ASV0598     -2.172774e-04 -2.268131e-04 -2.367307e-04 -2.470422e-04
## ASV0429      3.455799e-04  3.611171e-04  3.773107e-04  3.941847e-04
## ASV1549      3.479274e-04  3.642571e-04  3.813412e-04  3.992133e-04
## ASV1203      2.595382e-04  2.711674e-04  2.832836e-04  2.959042e-04
## ASV4532      1.100382e-05  1.140281e-05  1.181141e-05  1.222954e-05
## ASV0274     -2.586574e-04 -2.698413e-04 -2.814593e-04 -2.935240e-04
## ASV0163     -3.722728e-04 -3.884363e-04 -4.052310e-04 -4.226751e-04
## ASV1298      1.522088e-04  1.588475e-04  1.657474e-04  1.729162e-04
## ASV9424     -3.227792e-04 -3.377118e-04 -3.533128e-04 -3.696099e-04
## ASV0412      4.926992e-04  5.149168e-04  5.380785e-04  5.622195e-04
## ASV0284      2.186597e-04  2.282138e-04  2.381454e-04  2.484658e-04
## ASV0620     -1.664428e-04 -1.743127e-04 -1.825491e-04 -1.911683e-04
## ASV0153     -3.413759e-04 -3.571274e-04 -3.735827e-04 -3.907713e-04
## ASV0498      3.944744e-05  4.177048e-05  4.423973e-05  4.686462e-05
## ASV0097      2.425326e-04  2.536756e-04  2.653118e-04  2.774611e-04
## ASV0104     -1.129196e-03 -1.180212e-03 -1.233409e-03 -1.288869e-03
## ASV1282      1.996515e-04  2.088987e-04  2.185597e-04  2.286518e-04
## ASV3883     -1.114352e-04 -1.164760e-04 -1.217306e-04 -1.272066e-04
## ASV0801      1.180196e-04  1.238102e-04  1.298894e-04  1.362718e-04
## ASV1611     -4.334412e-04 -4.531687e-04 -4.737505e-04 -4.952196e-04
## ASV0227     -1.537602e-04 -1.608675e-04 -1.682928e-04 -1.760492e-04
## ASV0833      1.706419e-04  1.787733e-04  1.872902e-04  1.962105e-04
## ASV0718      4.098356e-04  4.286785e-04  4.483565e-04  4.689037e-04
## ASV1139      1.535994e-04  1.604479e-04  1.675800e-04  1.750054e-04
## ASV0766     -1.091714e-04 -1.139457e-04 -1.189085e-04 -1.240652e-04
## ASV2091      5.397119e-04  5.634211e-04  5.880834e-04  6.137292e-04
## ASV1238     -2.761769e-05 -2.827988e-05 -2.892023e-05 -2.953379e-05
## ASV9193     -5.910331e-05 -6.246991e-05 -6.603847e-05 -6.982116e-05
## ASV0290     -4.190559e-05 -4.382430e-05 -4.582645e-05 -4.791519e-05
## ASV0231      4.264836e-04  4.455525e-04  4.654165e-04  4.861036e-04
## ASV0185      8.243342e-05  8.734513e-05  9.257475e-05  9.814400e-05
## ASV2330      1.240608e-04  1.295709e-04  1.353082e-04  1.412804e-04
## ASV3119     -1.434664e-04 -1.504577e-04 -1.577933e-04 -1.654901e-04
## ASV2368     -1.986988e-04 -2.080293e-04 -2.177900e-04 -2.280001e-04
## ASV0122     -1.562101e-04 -1.631724e-04 -1.704255e-04 -1.779801e-04
## ASV1044      2.735318e-04  2.866016e-04  3.002961e-04  3.146450e-04
## ASV0160     -3.784025e-04 -3.947886e-04 -4.118111e-04 -4.294885e-04
## ASV0326      2.463787e-04  2.575648e-04  2.692335e-04  2.814034e-04
## ASV1388      4.311879e-04  4.506418e-04  4.709244e-04  4.920666e-04
## ASV0792      4.943390e-04  5.166722e-04  5.399587e-04  5.642340e-04
## ASV0036     -3.126149e-04 -3.271504e-04 -3.423454e-04 -3.582284e-04
## ASV2125      5.074101e-04  5.304463e-04  5.544773e-04  5.795416e-04
## ASV1075      9.695802e-05  1.015071e-04  1.062675e-04  1.112490e-04
## ASV0390      1.000860e-04  1.051964e-04  1.105802e-04  1.162529e-04
## ASV3790     -3.976255e-04 -4.153902e-04 -4.338949e-04 -4.531657e-04
## ASV1535     -3.383239e-05 -3.549750e-05 -3.724404e-05 -3.907568e-05
## ASV0263      8.661457e-05  9.068439e-05  9.494197e-05  9.939556e-05
## ASV0675      6.735378e-04  7.049750e-04  7.378465e-04  7.722142e-04
## ASV3348      6.553131e-05  6.873222e-05  7.209261e-05  7.562065e-05
## ASV0058     -6.337618e-04 -6.621702e-04 -6.917732e-04 -7.226142e-04
## ASV4142      1.562660e-04  1.631320e-04  1.702742e-04  1.777015e-04
## ASV0059     -5.462487e-04 -5.706799e-04 -5.961337e-04 -6.226467e-04
## ASV0013     -1.144833e-03 -1.196479e-03 -1.250326e-03 -1.306456e-03
## ASV0033     -3.410020e-04 -3.569115e-04 -3.735476e-04 -3.909421e-04
## ASV4354     -1.473325e-04 -1.538765e-04 -1.606893e-04 -1.677802e-04
## ASV0022     -3.600688e-04 -3.768544e-04 -3.944053e-04 -4.127547e-04
## ASV0134     -9.171663e-05 -9.625127e-05 -1.010162e-04 -1.060236e-04
## ASV0415     -7.385864e-05 -7.681176e-05 -7.985743e-05 -8.299630e-05
## ASV10103    -2.491589e-04 -2.605566e-04 -2.724532e-04 -2.848683e-04
## ASV1613      4.054657e-04  4.237587e-04  4.428314e-04  4.627131e-04
## ASV0135     -2.487630e-05 -2.568630e-05 -2.650133e-05 -2.731878e-05
## ASV0469     -5.037471e-04 -5.262996e-04 -5.497964e-04 -5.742714e-04
## ASV0471      3.245378e-04  3.395527e-04  3.552392e-04  3.716251e-04
## ASV0451     -8.697313e-05 -9.114166e-05 -9.551140e-05 -1.000922e-04
## ASV0747      1.206897e-04  1.262557e-04  1.320685e-04  1.381382e-04
## ASV1314     -1.922646e-04 -2.014069e-04 -2.109808e-04 -2.210063e-04
## ASV0425     -5.687602e-04 -5.938285e-04 -6.199118e-04 -6.470435e-04
## ASV0559     -3.203629e-04 -3.342994e-04 -3.487829e-04 -3.638299e-04
## ASV0148     -3.501057e-04 -3.654367e-04 -3.813795e-04 -3.979533e-04
## ASV0129     -1.737363e-04 -1.810763e-04 -1.886857e-04 -1.965710e-04
## ASV1072      1.684197e-04  1.756871e-04  1.832355e-04  1.910732e-04
## ASV2390      1.227093e-04  1.281212e-04  1.337522e-04  1.396093e-04
## ASV0548      3.700480e-04  3.870718e-04  4.048523e-04  4.234208e-04
## ASV0168     -5.494889e-04 -5.739226e-04 -5.993659e-04 -6.258541e-04
## ASV0066     -4.125166e-04 -4.311909e-04 -4.506669e-04 -4.709753e-04
## ASV0468     -1.578575e-04 -1.653121e-04 -1.731149e-04 -1.812819e-04
## ASV0172     -8.514247e-05 -8.848510e-05 -9.192662e-05 -9.546704e-05
## ASV0236     -2.098058e-04 -2.184835e-04 -2.274610e-04 -2.367434e-04
## ASV0250      1.408227e-05  1.560642e-05  1.727422e-05  1.909783e-05
## ASV0338     -2.307367e-05 -2.338215e-05 -2.363945e-05 -2.383821e-05
## ASV0450      9.981357e-07  1.186206e-06  1.395265e-06  1.627258e-06
## ASV0377      4.536758e-04  4.743454e-04  4.959136e-04  5.184157e-04
## ASV1022      1.289362e-04  1.349744e-04  1.412901e-04  1.478957e-04
## ASV6174     -2.849229e-05 -2.960781e-05 -3.075436e-05 -3.193147e-05
## ASV0786      5.183651e-05  5.411941e-05  5.649393e-05  5.896291e-05
## ASV0053     -5.445022e-04 -5.693179e-04 -5.952138e-04 -6.222325e-04
## ASV0697     -1.566676e-04 -1.634762e-04 -1.705522e-04 -1.779037e-04
## ASV0785      4.047074e-04  4.231251e-04  4.423445e-04  4.623974e-04
## ASV1967     -2.700081e-04 -2.820443e-04 -2.945795e-04 -3.076311e-04
## ASV0385     -1.225874e-04 -1.278191e-04 -1.332496e-04 -1.388845e-04
## ASV0295      1.396888e-07  5.039558e-07  9.162689e-07  1.381348e-06
## ASV0072     -4.321479e-04 -4.512681e-04 -4.711706e-04 -4.918818e-04
## ASV0157     -1.752872e-04 -1.826266e-04 -1.902252e-04 -1.980875e-04
## ASV0501      2.009594e-04  2.104838e-04  2.204516e-04  2.308823e-04
## ASV10729    -3.332345e-04 -3.485738e-04 -3.645934e-04 -3.813207e-04
## ASV1470      1.480746e-04  1.542621e-04  1.606707e-04  1.673052e-04
## ASV0050     -1.080391e-03 -1.128878e-03 -1.179410e-03 -1.232058e-03
## ASV0411     -2.962727e-05 -3.088136e-05 -3.218379e-05 -3.353624e-05
## ASV0549      2.071825e-04  2.169324e-04  2.271365e-04  2.378156e-04
## ASV0184      1.280127e-04  1.338759e-04  1.399968e-04  1.463859e-04
## ASV0705      1.561034e-04  1.634807e-04  1.712019e-04  1.792824e-04
## ASV1715      3.848537e-04  4.023886e-04  4.206864e-04  4.397773e-04
## ASV0603      4.918044e-05  5.164243e-05  5.423200e-05  5.695606e-05
## ASV0826      1.284344e-04  1.340730e-04  1.399375e-04  1.460351e-04
## ASV0034     -4.908479e-04 -5.128242e-04 -5.357201e-04 -5.595685e-04
## ASV0838      1.155724e-04  1.213136e-04  1.273449e-04  1.336807e-04
## ASV0614     -2.844597e-04 -2.974992e-04 -3.111132e-04 -3.253249e-04
## ASV0014     -1.047930e-03 -1.095032e-03 -1.144125e-03 -1.195283e-03
## ASV0585     -6.068838e-05 -6.323978e-05 -6.588350e-05 -6.862161e-05
## ASV0016     -1.071602e-03 -1.119805e-03 -1.170049e-03 -1.222409e-03
## ASV5394     -2.758174e-04 -2.885570e-04 -3.018656e-04 -3.157667e-04
## ASV0666      2.329695e-04  2.435199e-04  2.545226e-04  2.659947e-04
## ASV2085      9.123468e-05  9.490276e-05  9.868693e-05  1.025880e-04
## ASV0003     -9.800633e-04 -1.024054e-03 -1.069898e-03 -1.117665e-03
## ASV0346     -1.668266e-05 -1.687356e-05 -1.702215e-05 -1.712243e-05
## ASV0267     -1.593004e-04 -1.664062e-04 -1.738071e-04 -1.815136e-04
## ASV0353      2.139515e-04  2.243032e-04  2.351563e-04  2.465344e-04
## ASV2419      2.780585e-04  2.905414e-04  3.035508e-04  3.171057e-04
## ASV0447      1.329120e-04  1.395226e-04  1.464699e-04  1.537713e-04
## ASV0654      4.278313e-04  4.473655e-04  4.677518e-04  4.890236e-04
## ASV0151      6.695693e-05  7.033498e-05  7.389054e-05  7.763341e-05
## ASV0065     -3.959430e-04 -4.137970e-04 -4.324122e-04 -4.518173e-04
## ASV0527      2.900561e-04  3.033068e-04  3.171372e-04  3.315702e-04
## ASV4055     -1.139870e-04 -1.196289e-04 -1.255578e-04 -1.317887e-04
## ASV0166     -3.216133e-04 -3.354706e-04 -3.498606e-04 -3.647982e-04
## ASV0417     -2.781549e-04 -2.905705e-04 -3.035029e-04 -3.169702e-04
## ASV0078     -2.227343e-04 -2.325603e-04 -2.427859e-04 -2.534245e-04
## ASV0322     -2.662265e-04 -2.777399e-04 -2.897005e-04 -3.021213e-04
## ASV0156     -3.445367e-04 -3.595146e-04 -3.750810e-04 -3.912537e-04
## ASV0648     -3.228564e-04 -3.378308e-04 -3.534794e-04 -3.698306e-04
## ASV0407      1.800240e-05  1.865225e-05  1.931582e-05  1.999247e-05
## ASV2030     -6.715396e-05 -6.994706e-05 -7.283736e-05 -7.582649e-05
## ASV0300      1.931530e-04  2.025538e-04  2.124161e-04  2.227624e-04
## ASV1150     -2.725171e-05 -2.849157e-05 -2.978487e-05 -3.113363e-05
## ASV0958      1.980461e-04  2.075392e-04  2.174884e-04  2.279157e-04
## ASV0216     -3.392103e-04 -3.543166e-04 -3.700474e-04 -3.864241e-04
## ASV0446      4.720229e-04  4.941524e-04  5.172993e-04  5.415080e-04
## ASV0367     -1.602296e-04 -1.674452e-04 -1.749672e-04 -1.828068e-04
## ASV0200     -2.939802e-04 -3.071144e-04 -3.207988e-04 -3.350534e-04
## ASV0334     -1.482709e-04 -1.541213e-04 -1.601450e-04 -1.663418e-04
## ASV1311      2.178999e-04  2.280133e-04  2.385843e-04  2.496323e-04
## ASV0458      2.287780e-04  2.391232e-04  2.499116e-04  2.611600e-04
## ASV1371      3.557794e-06  3.580721e-06  3.591808e-06  3.589415e-06
## ASV0418      2.688763e-04  2.806498e-04  2.928934e-04  3.056218e-04
## ASV0004      3.274057e-04  3.420861e-04  3.573840e-04  3.733216e-04
## ASV1943      2.402449e-04  2.509073e-04  2.620084e-04  2.735634e-04
## ASV1495     -5.967808e-05 -6.270760e-05 -6.589689e-05 -6.925470e-05
## ASV0901     -3.789871e-04 -3.965833e-04 -4.149754e-04 -4.341974e-04
## ASV0628      2.227915e-04  2.328593e-04  2.433579e-04  2.543037e-04
## ASV0400      8.745943e-05  9.131641e-05  9.532807e-05  9.949913e-05
## ASV0116     -2.826392e-04 -2.954787e-04 -3.088735e-04 -3.228452e-04
## ASV0788      2.378475e-04  2.486170e-04  2.598486e-04  2.715600e-04
## ASV0117      1.536947e-04  1.609395e-04  1.685219e-04  1.764573e-04
## ASV3137      4.255571e-05  4.448248e-05  4.649271e-05  4.858977e-05
## ASV0001      3.991065e-04  4.169243e-04  4.354857e-04  4.548172e-04
## ASV1651      2.553356e-04  2.662082e-04  2.774853e-04  2.891767e-04
## ASV1692      2.847351e-04  2.980890e-04  3.120581e-04  3.266698e-04
## ASV0660      1.615598e-04  1.685382e-04  1.757837e-04  1.833032e-04
## ASV0508      2.146879e-05  2.238307e-05  2.333113e-05  2.431373e-05
## ASV1660     -1.150889e-04 -1.204753e-04 -1.261079e-04 -1.319973e-04
## ASV0233      6.488785e-05  6.798051e-05  7.122104e-05  7.461656e-05
## ASV1343     -2.847176e-04 -2.977572e-04 -3.113695e-04 -3.255776e-04
## ASV0209      2.682625e-04  2.803365e-04  2.929232e-04  3.060420e-04
## ASV0193     -3.333672e-04 -3.478113e-04 -3.628188e-04 -3.784062e-04
## ASV0357     -2.576605e-05 -2.690465e-05 -2.808799e-05 -2.931718e-05
## ASV0198      7.676214e-05  8.043679e-05  8.428626e-05  8.831864e-05
## ASV0007      3.790424e-04  3.959975e-04  4.136632e-04  4.320652e-04
## ASV1772     -3.739713e-05 -3.901561e-05 -4.069648e-05 -4.244145e-05
## ASV0009      3.579861e-04  3.739947e-04  3.906739e-04  4.080480e-04
## ASV0006      1.435079e-04  1.496478e-04  1.560199e-04  1.626303e-04
## ASV0011     -3.985095e-04 -4.168622e-04 -4.360299e-04 -4.560460e-04
## ASV0015      2.759564e-04  2.883828e-04  3.013366e-04  3.148373e-04
## ASV0017      2.922412e-04  3.053822e-04  3.190793e-04  3.333531e-04
## ASV0235     -2.302313e-04 -2.406955e-04 -2.516106e-04 -2.629936e-04
## ASV0382      4.483035e-05  4.742153e-05  5.017346e-05  5.309647e-05
## ASV2357      3.510328e-04  3.669709e-04  3.835967e-04  4.009365e-04
## ASV0567     -2.566824e-04 -2.682330e-04 -2.802740e-04 -2.928239e-04
## ASV0165      2.824909e-04  2.953896e-04  3.088508e-04  3.228966e-04
## ASV0005      5.596413e-04  5.845493e-04  6.104876e-04  6.374922e-04
## ASV0384     -2.983630e-05 -3.109618e-05 -3.240196e-05 -3.375466e-05
## ASV0002      1.185841e-04  1.240492e-04  1.297574e-04  1.357185e-04
## ASV3017      3.278666e-04  3.424349e-04  3.576037e-04  3.733936e-04
## ASV0091      1.259982e-04  1.317957e-04  1.378497e-04  1.441707e-04
## ASV0186     -3.360265e-04 -3.512038e-04 -3.670285e-04 -3.835247e-04
## ASV0370      3.668371e-05  3.852375e-05  4.045999e-05  4.249781e-05
## ASV0018      5.830333e-04  6.090358e-04  6.361189e-04  6.643206e-04
## ASV1377      5.123445e-04  5.352741e-04  5.591623e-04  5.840434e-04
## ASV0019      5.838414e-04  6.098875e-04  6.370168e-04  6.652674e-04
## ASV0023      4.164852e-05  4.317469e-05  4.473475e-05  4.632731e-05
## ASV2194      1.883935e-04  1.969542e-04  2.058874e-04  2.152082e-04
## ASV1155     -1.788088e-05 -1.833575e-05 -1.877803e-05 -1.920439e-05
## ASV0510     -2.100245e-04 -2.188060e-04 -2.279005e-04 -2.373144e-04
## ASV2371     -2.117179e-04 -2.209612e-04 -2.305699e-04 -2.405552e-04
## ASV0024      1.343038e-05  1.367518e-05  1.389852e-05  1.409683e-05
## ASV2452      2.765858e-04  2.888482e-04  3.016140e-04  3.149003e-04
## ASV2332      5.114138e-06  5.342476e-06  5.581743e-06  5.832650e-06
## ASV2591      1.134690e-05  1.219500e-05  1.310960e-05  1.409590e-05
## ASV0521      3.856004e-04  4.037781e-04  4.228002e-04  4.427046e-04
## ASV5542      1.154753e-04  1.208476e-04  1.264633e-04  1.323327e-04
## ASV0336     -1.694828e-04 -1.767893e-04 -1.843773e-04 -1.922547e-04
## ASV10102     2.603128e-04  2.721769e-04  2.845562e-04  2.974709e-04
## ASV16823    -2.072881e-04 -2.163884e-04 -2.258534e-04 -2.356947e-04
## ASV3104      2.072719e-04  2.163708e-04  2.258342e-04  2.356738e-04
## ASV0781      1.028848e-04  1.076684e-04  1.126689e-04  1.178959e-04
## ASV10899     9.512916e-05  9.977107e-05  1.046425e-04  1.097548e-04
## ASV11222    -2.072611e-04 -2.163591e-04 -2.258215e-04 -2.356600e-04
## ASV11327    -2.072449e-04 -2.163415e-04 -2.258023e-04 -2.356391e-04
## ASV12458    -2.072287e-04 -2.163238e-04 -2.257831e-04 -2.356182e-04
## ASV1636     -1.678410e-04 -1.751142e-04 -1.826698e-04 -1.905161e-04
## ASV1890     -2.058203e-04 -2.148928e-04 -2.243324e-04 -2.341509e-04
## ASV2898      4.461011e-04  4.662233e-04  4.872018e-04  5.090686e-04
## ASV8328     -3.422867e-05 -3.533666e-05 -3.645222e-05 -3.757205e-05
## ASV0709     -3.614010e-04 -3.776005e-04 -3.944801e-04 -4.120644e-04
## ASV0856      6.027581e-05  6.327901e-05  6.643659e-05  6.975680e-05
## ASV0909     -1.509997e-04 -1.572383e-04 -1.636909e-04 -1.703609e-04
## ASV0937     -2.826899e-04 -2.955529e-04 -3.089737e-04 -3.229740e-04
## ASV11390    -2.071943e-04 -2.162864e-04 -2.257424e-04 -2.355740e-04
## ASV11966     1.016641e-04  1.063525e-04  1.112490e-04  1.163622e-04
## ASV12990     5.724110e-05  5.994481e-05  6.277480e-05  6.573682e-05
## ASV14797     2.142728e-04  2.238543e-04  2.338361e-04  2.442323e-04
## ASV14904    -2.071897e-04 -2.162814e-04 -2.257370e-04 -2.355681e-04
## ASV15304     5.230783e-05  5.480820e-05  5.742718e-05  6.017020e-05
## ASV16696    -2.071760e-04 -2.162666e-04 -2.257209e-04 -2.355506e-04
## ASV1690      1.056069e-04  1.106613e-04  1.159567e-04  1.215045e-04
## ASV2029      5.708648e-04  5.966449e-04  6.235245e-04  6.515448e-04
## ASV2834      3.024552e-04  3.160743e-04  3.302702e-04  3.450640e-04
## ASV4003      8.914202e-05  9.367580e-05  9.845023e-05  1.034787e-04
## ASV4064      2.085314e-04  2.179086e-04  2.276819e-04  2.378657e-04
## ASV4294      7.659742e-05  8.051007e-05  8.463202e-05  8.897510e-05
## ASV4609     -1.027039e-05 -1.070755e-05 -1.116042e-05 -1.162924e-05
## ASV6283     -2.071737e-04 -2.162642e-04 -2.257185e-04 -2.355481e-04
## ASV6491     -2.071575e-04 -2.162465e-04 -2.256993e-04 -2.355273e-04
## ASV7453      8.240966e-05  8.650915e-05  9.081732e-05  9.534493e-05
## ASV7959      1.439988e-05  1.528803e-05  1.623528e-05  1.724569e-05
## ASV8219      2.071461e-04  2.162341e-04  2.256859e-04  2.355128e-04
## ASV8547     -2.071299e-04 -2.162165e-04 -2.256667e-04 -2.354919e-04
## ASV9319      1.365146e-04  1.427125e-04  1.491774e-04  1.559192e-04
## ASV9382     -2.071197e-04 -2.162055e-04 -2.256547e-04 -2.354788e-04
## ASV11516    -2.071036e-04 -2.161879e-04 -2.256355e-04 -2.354579e-04
## ASV14377    -2.070874e-04 -2.161703e-04 -2.256163e-04 -2.354371e-04
## ASV1867      3.031573e-04  3.171347e-04  3.317349e-04  3.469837e-04
## ASV1895     -7.099376e-05 -7.409940e-05 -7.732885e-05 -8.068604e-05
## ASV3168      1.274011e-04  1.330492e-04  1.389285e-04  1.450466e-04
## ASV4449      2.576244e-04  2.690625e-04  2.809710e-04  2.933660e-04
## ASV6596      1.518194e-04  1.592637e-04  1.670809e-04  1.752901e-04
## ASV7492     -7.770069e-05 -8.086899e-05 -8.414172e-05 -8.752009e-05
## ASV9854     -1.061408e-04 -1.107016e-04 -1.154359e-04 -1.203483e-04
## ASV6296      2.070533e-04  2.161332e-04  2.255761e-04  2.353934e-04
## ASV4201      6.793306e-05  7.149135e-05  7.524631e-05  7.920938e-05
## ASV0552      5.082262e-04  5.317152e-04  5.562546e-04  5.818879e-04
## ASV3671     -4.062297e-05 -4.208254e-05 -4.356992e-05 -4.508302e-05
## ASV3529     -4.734894e-05 -4.921120e-05 -5.112832e-05 -5.310020e-05
## ASV1060      1.296716e-04  1.357739e-04  1.421602e-04  1.488436e-04
## ASV0239     -2.815177e-04 -2.936007e-04 -3.061421e-04 -3.191538e-04
## ASV5711     -2.641963e-04 -2.758488e-04 -2.879733e-04 -3.005853e-04
## ASV4152     -3.470827e-04 -3.625195e-04 -3.785932e-04 -3.953257e-04
## ASV1461      3.110482e-04  3.247595e-04  3.390258e-04  3.538650e-04
## ASV2877      2.519403e-04  2.631782e-04  2.748827e-04  2.870702e-04
## ASV0012      1.888251e-04  1.975272e-04  2.066161e-04  2.161076e-04
## ASV9823      5.921183e-05  6.134806e-05  6.353013e-05  6.575613e-05
## ASV0008      2.062780e-04  2.157309e-04  2.255994e-04  2.359001e-04
## ASV7832     -2.162382e-04 -2.259053e-04 -2.359758e-04 -2.464641e-04
## ASV1915      1.707366e-05  1.802086e-05  1.902393e-05  2.008629e-05
## ASV0055      1.482018e-04  1.549114e-04  1.619084e-04  1.692038e-04
## ASV0032      3.639723e-04  3.804972e-04  3.977360e-04  4.157166e-04
## ASV2977     -2.925800e-04 -3.056001e-04 -3.191581e-04 -3.332723e-04
## ASV0466      2.946452e-04  3.075141e-04  3.208923e-04  3.347956e-04
## ASV3866      3.160479e-04  3.305999e-04  3.457984e-04  3.616699e-04
## ASV0040      4.144775e-04  4.334065e-04  4.531616e-04  4.737752e-04
## ASV0496     -2.414267e-05 -2.564161e-05 -2.724190e-05 -2.895072e-05
## ASV0052      5.060329e-04  5.287042e-04  5.523264e-04  5.769336e-04
## ASV3828     -3.163543e-04 -3.306331e-04 -3.455214e-04 -3.610420e-04
## ASV1930      1.976510e-04  2.067473e-04  2.162464e-04  2.261646e-04
## ASV2126      3.188671e-04  3.333385e-04  3.484343e-04  3.641786e-04
## ASV0793      1.864487e-04  1.950588e-04  2.040544e-04  2.134517e-04
## ASV0299     -1.320674e-04 -1.376389e-04 -1.434116e-04 -1.493898e-04
## ASV0208      3.032856e-04  3.176636e-04  3.327171e-04  3.484772e-04
## ASV0511     -1.590306e-04 -1.657051e-04 -1.726185e-04 -1.797754e-04
## ASV1123     -2.084592e-04 -2.173711e-04 -2.266179e-04 -2.362082e-04
## ASV0099     -1.118731e-04 -1.166396e-04 -1.215835e-04 -1.267092e-04
## ASV0752     -2.491176e-05 -2.626074e-05 -2.768794e-05 -2.919818e-05
## ASV0883      1.439348e-06  1.535258e-06  1.638436e-06  1.749498e-06
## ASV0683      2.689403e-04  2.815999e-04  2.948475e-04  3.087096e-04
## ASV4117     -3.124358e-04 -3.262699e-04 -3.406691e-04 -3.556520e-04
## ASV2172      1.169819e-04  1.222888e-04  1.278250e-04  1.335992e-04
## ASV0330     -2.145467e-04 -2.243914e-04 -2.346723e-04 -2.454074e-04
## ASV0728      1.922269e-04  2.006973e-04  2.095114e-04  2.186805e-04
## ASV0499      4.067551e-04  4.259239e-04  4.459845e-04  4.669775e-04
## ASV0120     -4.425601e-04 -4.625576e-04 -4.834083e-04 -5.051440e-04
## ASV1446      3.703780e-05  3.845944e-05  3.991857e-05  4.141445e-05
## ASV17171    -3.009125e-04 -3.144738e-04 -3.286111e-04 -3.433459e-04
## ASV0533      8.631854e-05  9.041970e-05  9.471401e-05  9.921031e-05
## ASV2495     -1.204684e-04 -1.259664e-04 -1.317045e-04 -1.376922e-04
## ASV5582      1.040578e-04  1.084796e-04  1.130658e-04  1.178203e-04
## ASV1488      1.067200e-04  1.121187e-04  1.177964e-04  1.237675e-04
## ASV0682      2.836894e-04  2.970682e-04  3.110695e-04  3.257213e-04
## ASV0068     -1.577101e-05 -1.670003e-05 -1.768778e-05 -1.873808e-05
## ASV1987     -1.503022e-04 -1.574395e-04 -1.649133e-04 -1.727391e-04
## ASV0035      5.287748e-05  5.486689e-05  5.690401e-05  5.898715e-05
## ASV7192     -1.998722e-04 -2.085671e-04 -2.176027e-04 -2.269888e-04
## ASV0873      2.990099e-05  3.102346e-05  3.217369e-05  3.335100e-05
## ASV4749      1.885677e-05  1.939393e-05  1.992531e-05  2.044809e-05
## ASV2174      1.830421e-04  1.906596e-04  1.985477e-04  2.067122e-04
## ASV1476     -1.643400e-04 -1.717066e-04 -1.793829e-04 -1.873800e-04
## ASV0740     -4.076822e-04 -4.266457e-04 -4.464691e-04 -4.671893e-04
## ASV0170      8.668391e-05  9.064493e-05  9.477981e-05  9.909556e-05
## ASV2466     -3.709769e-04 -3.878887e-04 -4.055375e-04 -4.239524e-04
## ASV1709      2.854936e-04  2.983036e-04  3.116530e-04  3.255616e-04
## ASV6170     -2.422291e-04 -2.524467e-04 -2.630412e-04 -2.740221e-04
## ASV3673      2.900704e-04  3.029216e-04  3.163030e-04  3.302333e-04
## ASV1745      1.784283e-05  1.846048e-05  1.909007e-05  1.973110e-05
## ASV0380     -1.932004e-04 -2.012058e-04 -2.094941e-04 -2.180715e-04
## ASV0426     -5.855639e-05 -6.086043e-05 -6.323251e-05 -6.567253e-05
## ASV0202     -5.853337e-05 -6.044040e-05 -6.236191e-05 -6.429247e-05
## ASV6350     -2.434282e-04 -2.538245e-04 -2.646171e-04 -2.758174e-04
## ASV0713     -1.742479e-04 -1.820628e-04 -1.902078e-04 -1.986951e-04
## ASV1822      3.467453e-05  3.636012e-05  3.812608e-05  3.997589e-05
## ASV4569      2.817148e-04  2.942579e-04  3.073225e-04  3.209274e-04
## ASV0030     -6.326305e-05 -6.632271e-05 -6.953009e-05 -7.289210e-05
## ASV0331      1.176929e-04  1.234312e-04  1.294535e-04  1.357742e-04
## ASV2981      2.868591e-04  3.002010e-04  3.141453e-04  3.287173e-04
## ASV0828     -1.914811e-04 -2.005047e-04 -2.099465e-04 -2.198249e-04
## ASV2440      4.540739e-04  4.752130e-04  4.973110e-04  5.204090e-04
## ASV3006     -1.960625e-04 -2.042072e-04 -2.126417e-04 -2.213727e-04
## ASV3875     -1.960481e-04 -2.041916e-04 -2.126248e-04 -2.213544e-04
## ASV4511      1.143515e-04  1.198046e-04  1.255166e-04  1.314998e-04
## ASV4700     -1.960338e-04 -2.041761e-04 -2.126080e-04 -2.213362e-04
## ASV5804     -1.960194e-04 -2.041605e-04 -2.125911e-04 -2.213179e-04
## ASV6826      2.106304e-04  2.205705e-04  2.309744e-04  2.418631e-04
## ASV7280      1.739679e-04  1.820808e-04  1.905593e-04  1.994183e-04
## ASV7535     -1.960120e-04 -2.041525e-04 -2.125825e-04 -2.213087e-04
## ASV0651     -2.036260e-04 -2.126382e-04 -2.220174e-04 -2.317756e-04
## ASV0913      2.751789e-04  2.880669e-04  3.015485e-04  3.156500e-04
## ASV10832    -1.959983e-04 -2.041376e-04 -2.125665e-04 -2.212913e-04
## ASV1117     -3.897097e-04 -4.071243e-04 -4.252678e-04 -4.441664e-04
## ASV11329     9.666691e-05  1.017709e-04  1.071575e-04  1.128427e-04
## ASV13209    -1.140288e-05 -1.132700e-05 -1.119998e-05 -1.101635e-05
## ASV1345      4.802232e-05  5.032779e-05  5.274046e-05  5.526466e-05
## ASV1719     -1.959760e-04 -2.041136e-04 -2.125405e-04 -2.212633e-04
## ASV1886      2.249752e-04  2.350781e-04  2.456104e-04  2.565887e-04
## ASV2158     -5.304733e-05 -5.491559e-05 -5.682186e-05 -5.876463e-05
## ASV2189      2.410780e-04  2.520829e-04  2.635691e-04  2.755559e-04
## ASV2257      1.775220e-04  1.854075e-04  1.936201e-04  2.021714e-04
## ASV2283      1.959442e-04  2.040790e-04  2.125030e-04  2.212226e-04
## ASV2328      1.959298e-04  2.040634e-04  2.124861e-04  2.212043e-04
## ASV2434     -2.902941e-04 -3.030142e-04 -3.162468e-04 -3.300092e-04
## ASV2648      1.958985e-04  2.040295e-04  2.124493e-04  2.211643e-04
## ASV2698      2.830558e-04  2.960963e-04  3.097185e-04  3.239468e-04
## ASV2775      3.373979e-04  3.520156e-04  3.672038e-04  3.829795e-04
## ASV3171      1.958687e-04  2.039971e-04  2.124141e-04  2.211261e-04
## ASV3227      2.490165e-04  2.596848e-04  2.707583e-04  2.822480e-04
## ASV3397      1.513911e-05  1.588561e-05  1.666650e-05  1.748289e-05
## ASV3444      2.807521e-04  2.929389e-04  3.056069e-04  3.187714e-04
## ASV3556      1.958315e-04  2.039567e-04  2.123702e-04  2.210785e-04
## ASV3606     -1.958171e-04 -2.039411e-04 -2.123533e-04 -2.210603e-04
## ASV4190      2.485207e-04  2.598504e-04  2.716745e-04  2.840128e-04
## ASV4197      2.865767e-04  2.989193e-04  3.117384e-04  3.250478e-04
## ASV4722      2.587635e-04  2.703588e-04  2.824420e-04  2.950308e-04
## ASV4765      6.553114e-05  6.868070e-05  7.197886e-05  7.543206e-05
## ASV4809      1.957818e-04  2.039027e-04  2.123116e-04  2.210150e-04
## ASV4846      1.843591e-04  1.928661e-04  2.017510e-04  2.110292e-04
## ASV4903     -5.054701e-05 -5.219720e-05 -5.386634e-05 -5.555133e-05
## ASV4944     -1.957675e-04 -2.038873e-04 -2.122951e-04 -2.209972e-04
## ASV5151     -7.392655e-05 -7.779785e-05 -8.187866e-05 -8.618028e-05
## ASV5413     -1.957568e-04 -2.038758e-04 -2.122827e-04 -2.209838e-04
## ASV5537     -1.957424e-04 -2.038602e-04 -2.122658e-04 -2.209656e-04
## ASV5688      1.957281e-04  2.038447e-04  2.122490e-04  2.209473e-04
## ASV5752      9.267199e-05  9.707347e-05  1.016784e-04  1.064954e-04
## ASV6122     -1.957174e-04 -2.038331e-04 -2.122365e-04 -2.209338e-04
## ASV6135      1.957030e-04  2.038175e-04  2.122196e-04  2.209156e-04
## ASV6188     -1.956886e-04 -2.038020e-04 -2.122028e-04 -2.208974e-04
## ASV6216      2.891007e-04  3.016805e-04  3.147586e-04  3.283509e-04
## ASV6242      1.956584e-04  2.037691e-04  2.121670e-04  2.208586e-04
## ASV6383      1.956440e-04  2.037535e-04  2.121502e-04  2.208404e-04
## ASV6781      1.956297e-04  2.037380e-04  2.121334e-04  2.208222e-04
## ASV6799     -1.956153e-04 -2.037225e-04 -2.121165e-04 -2.208039e-04
## ASV7374     -1.956010e-04 -2.037069e-04 -2.120997e-04 -2.207857e-04
## ASV7539     -1.955866e-04 -2.036914e-04 -2.120829e-04 -2.207675e-04
## ASV8591     -1.955723e-04 -2.036758e-04 -2.120660e-04 -2.207493e-04
## ASV8637      1.955580e-04  2.036603e-04  2.120492e-04  2.207311e-04
## ASV12796    -1.955436e-04 -2.036448e-04 -2.120324e-04 -2.207128e-04
## ASV1934      2.257804e-04  2.361657e-04  2.470119e-04  2.583377e-04
## ASV22549     1.261620e-05  1.380239e-05  1.508996e-05  1.648657e-05
## ASV29857    -1.955299e-04 -2.036299e-04 -2.120164e-04 -2.206956e-04
## ASV3215      2.745301e-04  2.873000e-04  3.006496e-04  3.146039e-04
## ASV3236     -1.955146e-04 -2.036134e-04 -2.119984e-04 -2.206761e-04
## ASV3954     -1.955003e-04 -2.035978e-04 -2.119816e-04 -2.206579e-04
## ASV4850      1.954860e-04  2.035823e-04  2.119648e-04  2.206397e-04
## ASV5225      1.954716e-04  2.035668e-04  2.119480e-04  2.206215e-04
## ASV5532     -1.954573e-04 -2.035513e-04 -2.119312e-04 -2.206033e-04
## ASV7258      2.400064e-05  2.591882e-05  2.799063e-05  3.022774e-05
## ASV9474     -1.116032e-04 -1.159500e-04 -1.204263e-04 -1.250329e-04
## ASV11857    -1.954380e-04 -2.035305e-04 -2.119088e-04 -2.205793e-04
## ASV1202     -1.954237e-04 -2.035150e-04 -2.118920e-04 -2.205611e-04
## ASV14742     1.387507e-04  1.455960e-04  1.527841e-04  1.603322e-04
## ASV16652     7.046761e-05  7.389382e-05  7.748445e-05  8.124678e-05
## ASV2019      2.861115e-04  2.986775e-04  3.117512e-04  3.253495e-04
## ASV2410     -2.661096e-04 -2.781154e-04 -2.906347e-04 -3.036872e-04
## ASV2718      2.836523e-04  2.970104e-04  3.109860e-04  3.256061e-04
## ASV2738      3.208756e-04  3.347053e-04  3.490683e-04  3.639802e-04
## ASV2876      1.953923e-04  2.034810e-04  2.118553e-04  2.205214e-04
## ASV3177      1.953780e-04  2.034655e-04  2.118385e-04  2.205032e-04
## ASV4367      1.953637e-04  2.034500e-04  2.118217e-04  2.204850e-04
## ASV4635      6.696100e-05  7.068775e-05  7.463161e-05  7.880518e-05
## ASV4896      1.669783e-05  1.832485e-05  2.009661e-05  2.202480e-05
## ASV4907      1.432490e-04  1.503982e-04  1.579109e-04  1.658054e-04
## ASV5230     -1.953630e-04 -2.034496e-04 -2.118216e-04 -2.204854e-04
## ASV6509     -1.953487e-04 -2.034341e-04 -2.118048e-04 -2.204672e-04
## ASV7376     -1.953344e-04 -2.034186e-04 -2.117880e-04 -2.204490e-04
## ASV8163     -1.953201e-04 -2.034031e-04 -2.117712e-04 -2.204309e-04
## ASV8195     -1.953058e-04 -2.033876e-04 -2.117545e-04 -2.204127e-04
## ASV8923      1.192616e-04  1.250634e-04  1.311472e-04  1.375263e-04
## ASV9666     -1.732302e-04 -1.803021e-04 -1.876147e-04 -1.951727e-04
## ASV1482      1.761719e-04  1.842339e-04  1.926476e-04  2.014265e-04
## ASV2726      2.325623e-04  2.434682e-04  2.548738e-04  2.668004e-04
## ASV3281     -1.952902e-04 -2.033708e-04 -2.117365e-04 -2.203934e-04
## ASV4235     -1.952759e-04 -2.033554e-04 -2.117197e-04 -2.203753e-04
## ASV4808      2.881086e-04  3.006064e-04  3.135954e-04  3.270906e-04
## ASV4861     -2.898640e-04 -3.025462e-04 -3.157381e-04 -3.294566e-04
## ASV5276      2.842510e-04  2.965364e-04  3.092998e-04  3.225554e-04
## ASV5837      2.467389e-04  2.581888e-04  2.701572e-04  2.826665e-04
## ASV7098      2.523565e-04  2.640329e-04  2.762353e-04  2.889861e-04
## ASV8451     -1.952106e-04 -2.032843e-04 -2.116425e-04 -2.202913e-04
## ASV8694     -1.951963e-04 -2.032689e-04 -2.116257e-04 -2.202732e-04
## ASV0905     -1.039508e-04 -1.087834e-04 -1.138309e-04 -1.191017e-04
## ASV2900      2.395770e-04  2.497363e-04  2.602761e-04  2.712069e-04
## ASV3963     -1.897980e-04 -1.976218e-04 -2.057188e-04 -2.140950e-04
## ASV0041     -2.116061e-04 -2.214183e-04 -2.316710e-04 -2.423825e-04
## ASV1865      2.162073e-04  2.266773e-04  2.376545e-04  2.491629e-04
## ASV1140      1.728994e-04  1.808832e-04  1.892197e-04  1.979226e-04
## ASV1179      2.552202e-04  2.670409e-04  2.793923e-04  2.922967e-04
## ASV0279      3.593882e-04  3.755004e-04  3.922930e-04  4.097913e-04
## ASV0043     -3.318809e-05 -3.517191e-05 -3.728550e-05 -3.953790e-05
## ASV2097     -2.014669e-04 -2.102539e-04 -2.193924e-04 -2.288943e-04
## ASV0309     -1.001068e-04 -1.044131e-04 -1.088859e-04 -1.135302e-04
## ASV0607      4.393259e-04  4.597729e-04  4.811481e-04  5.034912e-04
## ASV0025     -4.601162e-04 -4.814301e-04 -5.037004e-04 -5.269669e-04
## ASV2284     -7.255774e-05 -7.521991e-05 -7.794432e-05 -8.072927e-05
## ASV0556      7.845888e-05  8.241868e-05  8.658330e-05  9.096337e-05
## ASV5040      1.638345e-04  1.704736e-04  1.773344e-04  1.844204e-04
## ASV2924     -1.751736e-04 -1.823419e-04 -1.897560e-04 -1.974206e-04
## ASV1331      5.573924e-04  5.825387e-04  6.087578e-04  6.360902e-04
## ASV0506     -2.539551e-04 -2.648676e-04 -2.761976e-04 -2.879568e-04
## ASV1514      4.208209e-04  4.400263e-04  4.600686e-04  4.809807e-04
## ASV2144      3.489447e-04  3.644842e-04  3.806677e-04  3.975177e-04
## ASV2265      4.669744e-04  4.881148e-04  5.101621e-04  5.331509e-04
## ASV5156      1.001079e-04  1.040748e-04  1.081644e-04  1.123777e-04
## ASV5534      8.078612e-05  8.380629e-05  8.690238e-05  9.007298e-05
## ASV5747     -1.660556e-05 -1.807761e-05 -1.967336e-05 -2.140229e-05
## ASV6657      2.092056e-04  2.182382e-04  2.276210e-04  2.373643e-04
## ASV0658     -2.382867e-04 -2.485618e-04 -2.592341e-04 -2.703151e-04
## ASV0716      5.763231e-05  6.001355e-05  6.247655e-05  6.502266e-05
## ASV1657      1.013382e-04  1.053280e-04  1.094388e-04  1.136713e-04
## ASV1885     -6.210507e-06 -7.138151e-06 -8.159772e-06 -9.283214e-06
## ASV2333      5.146420e-04  5.376362e-04  5.615918e-04  5.865435e-04
## ASV3375      1.894093e-04  1.974614e-04  2.058154e-04  2.144794e-04
## ASV4317      2.013671e-04  2.105877e-04  2.202159e-04  2.302685e-04
## ASV9599     -1.665929e-05 -1.813588e-05 -1.973652e-05 -2.147073e-05
## ASV0175     -6.888060e-04 -7.194087e-04 -7.512711e-04 -7.844364e-04
## ASV1032      2.041255e-04  2.128071e-04  2.218137e-04  2.311539e-04
## ASV1235      4.478159e-06  4.188623e-06  3.844878e-06  3.441509e-06
## ASV1262      6.077288e-04  6.349315e-04  6.632734e-04  6.927953e-04
## ASV1320      1.509522e-04  1.584300e-04  1.662857e-04  1.745383e-04
## ASV13797     2.256532e-04  2.356072e-04  2.459678e-04  2.567491e-04
## ASV1491      1.154652e-04  1.212454e-04  1.273192e-04  1.337011e-04
## ASV15014    -1.668101e-05 -1.815923e-05 -1.976160e-05 -2.149764e-05
## ASV1510      1.867088e-04  1.957042e-04  2.051308e-04  2.150085e-04
## ASV1551     -7.437099e-05 -7.759422e-05 -8.094278e-05 -8.442027e-05
## ASV1919     -1.011042e-05 -9.830192e-06 -9.475733e-06 -9.039270e-06
## ASV2114      1.105898e-04  1.151954e-04  1.199669e-04  1.249082e-04
## ASV21486    -1.667277e-05 -1.814989e-05 -1.975102e-05 -2.148566e-05
## ASV2448      3.085923e-04  3.220250e-04  3.359874e-04  3.504957e-04
## ASV2589      1.475119e-04  1.537805e-04  1.602839e-04  1.670285e-04
## ASV2608      2.488452e-04  2.599139e-04  2.714421e-04  2.834464e-04
## ASV2786      2.018104e-04  2.109906e-04  2.205726e-04  2.305730e-04
## ASV2827      2.577667e-04  2.691193e-04  2.809311e-04  2.932172e-04
## ASV2872      2.098814e-04  2.187623e-04  2.279704e-04  2.375136e-04
## ASV3125      2.509926e-04  2.618359e-04  2.731011e-04  2.848007e-04
## ASV3247      2.718394e-04  2.835733e-04  2.957613e-04  3.084163e-04
## ASV3451     -1.675141e-05 -1.823543e-05 -1.984402e-05 -2.158674e-05
## ASV3465     -3.491614e-05 -3.727010e-05 -3.979102e-05 -4.249059e-05
## ASV3809      1.583413e-04  1.650613e-04  1.720319e-04  1.792595e-04
## ASV4006      3.370847e-04  3.515335e-04  3.665306e-04  3.820907e-04
## ASV4046      2.422129e-04  2.526729e-04  2.635393e-04  2.748242e-04
## ASV4938     -1.832866e-05 -1.988668e-05 -2.157266e-05 -2.339629e-05
## ASV5435     -1.677474e-05 -1.826044e-05 -1.987081e-05 -2.161539e-05
## ASV5605      9.691827e-05  1.005995e-04  1.043784e-04  1.082536e-04
## ASV5635     -1.677784e-05 -1.826362e-05 -1.987406e-05 -2.161868e-05
## ASV5743      3.056751e-04  3.190904e-04  3.330464e-04  3.475610e-04
## ASV6627     -1.679125e-05 -1.827811e-05 -1.988971e-05 -2.163559e-05
## ASV6785     -1.678870e-05 -1.827522e-05 -1.988643e-05 -2.163186e-05
## ASV7368      3.370277e-04  3.524543e-04  3.685613e-04  3.853766e-04
## ASV9118      9.149556e-05  9.501391e-05  9.863056e-05  1.023450e-04
## ASV9135      7.140971e-05  7.394067e-05  7.652089e-05  7.914749e-05
## ASV9435      1.590411e-04  1.654785e-04  1.721262e-04  1.789868e-04
## ASV9671     -1.681291e-05 -1.830132e-05 -1.991455e-05 -2.166214e-05
## ASV0387     -3.386890e-04 -3.533531e-04 -3.685885e-04 -3.844121e-04
## ASV0454     -3.369655e-04 -3.517122e-04 -3.670472e-04 -3.829888e-04
## ASV0751     -2.209678e-04 -2.304707e-04 -2.403382e-04 -2.505807e-04
## ASV1081      8.958495e-05  9.362311e-05  9.783173e-05  1.022169e-04
## ASV1332      1.843787e-04  1.925826e-04  2.011254e-04  2.100190e-04
## ASV2659      2.935570e-04  3.069582e-04  3.209415e-04  3.355293e-04
## ASV2979      3.047752e-04  3.178429e-04  3.314076e-04  3.454830e-04
## ASV4184      1.231845e-04  1.279324e-04  1.328130e-04  1.378256e-04
## ASV6198      1.073440e-04  1.118952e-04  1.166167e-04  1.215131e-04
## ASV7454      1.991183e-04  2.077104e-04  2.166348e-04  2.259009e-04
## ASV8198      7.987304e-05  8.274239e-05  8.567159e-05  8.865783e-05
## ASV0855      4.461242e-04  4.664591e-04  4.876801e-04  5.098223e-04
## ASV10092     1.885494e-04  1.966947e-04  2.051576e-04  2.139477e-04
## ASV1532      2.431133e-04  2.544657e-04  2.663366e-04  2.787485e-04
## ASV2553      5.874711e-04  6.139827e-04  6.416252e-04  6.704410e-04
## ASV2741      2.361855e-04  2.472656e-04  2.588531e-04  2.709696e-04
## ASV4095      1.280704e-04  1.343874e-04  1.410180e-04  1.479770e-04
## ASV5295      1.732701e-04  1.804184e-04  1.878143e-04  1.954623e-04
## ASV5787     -1.686916e-05 -1.836204e-05 -1.998003e-05 -2.173269e-05
## ASV9455      2.291084e-04  2.390619e-04  2.494082e-04  2.601595e-04
## ASV10879     2.390803e-04  2.497700e-04  2.609095e-04  2.725155e-04
## ASV3997      1.667878e-04  1.747847e-04  1.831618e-04  1.919365e-04
## ASV6760      4.713360e-05  4.848848e-05  4.983595e-05  5.117052e-05
## ASV6990      1.729259e-04  1.803198e-04  1.879956e-04  1.959612e-04
## ASV9560      1.070299e-04  1.113833e-04  1.158832e-04  1.205320e-04
## ASV0220      9.463765e-05  9.883227e-05  1.031977e-04  1.077393e-04
## ASV2518      2.305896e-04  2.410821e-04  2.520301e-04  2.634514e-04
## ASV3615      3.629653e-04  3.791510e-04  3.960110e-04  4.135693e-04
## ASV0075      7.865112e-05  8.179735e-05  8.504122e-05  8.838313e-05
## ASV8070      4.381730e-05  4.510153e-05  4.638215e-05  4.765438e-05
## ASV1658      1.718255e-04  1.792527e-04  1.869690e-04  1.949833e-04
## ASV0773      2.775403e-04  2.895022e-04  3.019250e-04  3.148218e-04
## ASV0799      8.902972e-06  9.291373e-06  9.694972e-06  1.011420e-05
## ASV1839     -5.471997e-05 -5.678377e-05 -5.889772e-05 -6.106016e-05
## ASV0265      2.674823e-04  2.801859e-04  2.934862e-04  3.074101e-04
## ASV3741      1.078185e-04  1.126455e-04  1.176747e-04  1.229135e-04
## ASV0847      3.748688e-04  3.917060e-04  4.092531e-04  4.275357e-04
## ASV1026      4.003680e-04  4.182041e-04  4.367788e-04  4.561177e-04
## ASV1222     -1.267177e-04 -1.318474e-04 -1.371467e-04 -1.426182e-04
## ASV0729      5.469077e-05  5.709800e-05  5.960209e-05  6.220611e-05
## ASV0143     -3.042335e-04 -3.173106e-04 -3.308875e-04 -3.449781e-04
## ASV1328      7.800525e-05  8.127247e-05  8.465757e-05  8.816324e-05
## ASV9078     -7.902089e-05 -8.339847e-05 -8.803135e-05 -9.293461e-05
## ASV0027     -4.382509e-04 -4.584465e-04 -4.795386e-04 -5.015638e-04
## ASV0546     -1.914154e-04 -1.996488e-04 -2.081983e-04 -2.170730e-04
## ASV1136      4.881987e-04  5.100183e-04  5.327514e-04  5.564313e-04
## ASV3081      2.331209e-04  2.437132e-04  2.547663e-04  2.662988e-04
## ASV0531      1.034588e-04  1.083743e-04  1.135193e-04  1.189036e-04
## ASV2525      1.336030e-04  1.393843e-04  1.453911e-04  1.516300e-04
## ASV1083     -5.061478e-05 -5.252803e-05 -5.449273e-05 -5.650858e-05
## ASV0424      8.699641e-05  9.098569e-05  9.515181e-05  9.950214e-05
## ASV0644      1.161799e-05  1.263697e-05  1.374007e-05  1.493353e-05
## ASV6007     -1.700890e-05 -1.851639e-05 -2.015055e-05 -2.192109e-05
## ASV0564      1.202804e-04  1.261148e-04  1.322321e-04  1.386455e-04
## ASV1938      1.296884e-04  1.350813e-04  1.406660e-04  1.464468e-04
## ASV6516     -2.978332e-04 -3.112042e-04 -3.251387e-04 -3.396570e-04
## ASV0503     -3.490962e-04 -3.640512e-04 -3.795729e-04 -3.956768e-04
## ASV6913     -3.468678e-04 -3.617193e-04 -3.771358e-04 -3.931330e-04
## ASV0164     -2.769508e-04 -2.899555e-04 -3.035611e-04 -3.177943e-04
## ASV1576      3.310182e-04  3.458890e-04  3.613901e-04  3.775452e-04
## ASV1725      1.606185e-04  1.683849e-04  1.765258e-04  1.850588e-04
## ASV4501      1.400248e-04  1.457865e-04  1.517465e-04  1.579085e-04
## ASV10678    -2.905474e-04 -3.034597e-04 -3.169039e-04 -3.308985e-04
## ASV0944      2.421448e-04  2.535097e-04  2.653981e-04  2.778333e-04
## ASV2292      3.771339e-04  3.938847e-04  4.113262e-04  4.294822e-04
## ASV1090      2.471544e-04  2.583626e-04  2.700548e-04  2.822499e-04
## ASV9117     -1.202572e-04 -1.251499e-04 -1.302072e-04 -1.354317e-04
## ASV0285     -1.460038e-04 -1.532398e-04 -1.608400e-04 -1.688226e-04
## ASV0463     -2.409857e-04 -2.514684e-04 -2.623631e-04 -2.736823e-04
## ASV3199      2.077784e-04  2.166544e-04  2.258665e-04  2.354239e-04
## ASV0150     -8.525382e-05 -8.945882e-05 -9.387385e-05 -9.850931e-05
## ASV6583     -1.233459e-04 -1.285431e-04 -1.339331e-04 -1.395210e-04
## ASV0392      1.977553e-04  2.067975e-04  2.162364e-04  2.260880e-04
## ASV14007    -2.390327e-04 -2.496789e-04 -2.607661e-04 -2.723096e-04
## ASV0177     -1.317441e-04 -1.373685e-04 -1.432052e-04 -1.492599e-04
## ASV6448     -1.026734e-04 -1.080795e-04 -1.137813e-04 -1.197949e-04
## ASV5399     -4.267590e-05 -4.534620e-05 -4.819319e-05 -5.122852e-05
## ASV0277     -4.931047e-05 -5.160912e-05 -5.401209e-05 -5.652380e-05
## ASV2599      8.139679e-05  8.416755e-05  8.698011e-05  8.982990e-05
## ASV13465    -6.514746e-05 -6.720748e-05 -6.928049e-05 -7.136090e-05
## ASV2412      1.238009e-04  1.294505e-04  1.353463e-04  1.414979e-04
## ASV0423      2.447836e-04  2.565667e-04  2.689205e-04  2.818728e-04
## ASV5187      1.508292e-04  1.569861e-04  1.633520e-04  1.699306e-04
## ASV0701     -5.695093e-04 -5.953242e-04 -6.222479e-04 -6.503224e-04
## ASV4248      1.364492e-04  1.430303e-04  1.499267e-04  1.571529e-04
## ASV0519      2.397094e-04  2.509046e-04  2.626091e-04  2.748446e-04
## ASV0764      4.139332e-05  4.360714e-05  4.594549e-05  4.841559e-05
## ASV5385     -2.997081e-04 -3.134019e-04 -3.276940e-04 -3.426081e-04
## ASV3021     -1.679823e-04 -1.746781e-04 -1.815853e-04 -1.887062e-04
## ASV4119     -9.353163e-05 -9.715603e-05 -1.008847e-04 -1.047176e-04
## ASV2534      4.874353e-05  5.085138e-05  5.304241e-05  5.531936e-05
## ASV1061      2.313042e-04  2.427897e-04  2.548603e-04  2.675465e-04
## ASV0670      3.195229e-04  3.341284e-04  3.493729e-04  3.652814e-04
## ASV1384      1.392781e-04  1.461630e-04  1.533930e-04  1.609851e-04
## ASV1981      2.978021e-04  3.115629e-04  3.259374e-04  3.409506e-04
## ASV9632     -9.739320e-05 -1.010346e-04 -1.047688e-04 -1.085944e-04
## ASV4564      7.344094e-05  7.687165e-05  8.045854e-05  8.420828e-05
## ASV5289     -6.634349e-05 -6.934378e-05 -7.247228e-05 -7.573378e-05
## ASV0516      6.055030e-04  6.330907e-04  6.618764e-04  6.919067e-04
## ASV1463     -2.176625e-04 -2.271892e-04 -2.370946e-04 -2.473905e-04
## ASV0969      1.010814e-04  1.054198e-04  1.099224e-04  1.145935e-04
## ASV1113     -2.820740e-04 -2.949187e-04 -3.083218e-04 -3.223054e-04
## ASV1234     -1.115916e-05 -1.232602e-05 -1.360257e-05 -1.499821e-05
## ASV3814      4.150791e-05  4.257397e-05  4.361772e-05  4.463295e-05
## ASV1000      2.878089e-04  3.005578e-04  3.138280e-04  3.276372e-04
## ASV0079     -2.616476e-05 -2.777180e-05 -2.948594e-05 -3.131465e-05
## ASV0145      9.733218e-05  1.013829e-04  1.055779e-04  1.099201e-04
## ASV0457     -3.622429e-04 -3.781451e-04 -3.946859e-04 -4.118856e-04
## ASV1485      1.185792e-04  1.241549e-04  1.299895e-04  1.360945e-04
## ASV0535     -7.980585e-05 -8.328450e-05 -8.690330e-05 -9.066718e-05
## ASV0259     -2.373989e-04 -2.480161e-04 -2.590750e-04 -2.705908e-04
## ASV0570      1.811377e-05  1.931595e-05  2.060289e-05  2.198059e-05
## ASV0906      3.085327e-04  3.222113e-04  3.364509e-04  3.512705e-04
## ASV1748     -1.832676e-04 -1.923121e-04 -2.018083e-04 -2.117785e-04
## ASV5520     -1.089768e-04 -1.147261e-04 -1.207919e-04 -1.271919e-04
## ASV2288     -3.532070e-04 -3.684983e-04 -3.843842e-04 -4.008820e-04
## ASV1887     -6.798525e-05 -7.170385e-05 -7.563502e-05 -7.979092e-05
## ASV0374     -1.120071e-04 -1.167780e-04 -1.217273e-04 -1.268598e-04
## ASV0823      3.481289e-04  3.633543e-04  3.791874e-04  3.956475e-04
## ASV0717      1.756203e-04  1.837071e-04  1.921533e-04  2.009735e-04
## ASV0431      1.207225e-04  1.259676e-04  1.314179e-04  1.370793e-04
## ASV1030      5.087301e-04  5.325576e-04  5.574775e-04  5.835375e-04
## ASV1082     -7.422587e-05 -7.760865e-05 -8.113822e-05 -8.482026e-05
## ASV2684      4.771942e-05  5.045878e-05  5.336324e-05  5.644270e-05
## ASV0051      4.517865e-04  4.726910e-04  4.945344e-04  5.173564e-04
## ASV0513      1.912284e-05  2.009569e-05  2.112007e-05  2.219883e-05
## ASV0581      5.726995e-04  5.988690e-04  6.261821e-04  6.546842e-04
## ASV7282      1.011060e-04  1.063042e-04  1.117822e-04  1.175560e-04
## ASV3009     -3.138905e-04 -3.281596e-04 -3.430457e-04 -3.585726e-04
## ASV2106     -1.587969e-04 -1.655471e-04 -1.725499e-04 -1.798118e-04
## ASV1012      1.011051e-04  1.060658e-04  1.112725e-04  1.167373e-04
## ASV0921     -6.554603e-06 -6.722224e-06 -6.885323e-06 -7.042676e-06
## ASV0010     -4.482562e-04 -4.690582e-04 -4.907972e-04 -5.135126e-04
## ASV1178      9.476655e-06  1.007879e-05  1.072048e-05  1.140418e-05
## ASV2848     -2.403169e-04 -2.509159e-04 -2.619472e-04 -2.734258e-04
## ASV0586      6.497186e-04  6.795117e-04  7.106167e-04  7.430864e-04
## ASV4225      1.965897e-05  2.089842e-05  2.221672e-05  2.361839e-05
## ASV2156     -2.707879e-04 -2.831727e-04 -2.961006e-04 -3.095932e-04
## ASV9778     -1.705246e-04 -1.781541e-04 -1.861022e-04 -1.943805e-04
## ASV0493     -3.774351e-04 -3.942035e-04 -4.116644e-04 -4.298419e-04
## ASV3770      6.904283e-05  7.190357e-05  7.486691e-05  7.793544e-05
## ASV0470      4.611258e-04  4.820933e-04  5.039692e-04  5.267888e-04
## ASV0262     -1.930338e-04 -2.025375e-04 -2.125157e-04 -2.229923e-04
## ASV0998      2.829650e-04  2.959807e-04  3.095737e-04  3.237679e-04
## ASV7708     -7.707965e-05 -8.045711e-05 -8.396930e-05 -8.762044e-05
## ASV0453     -9.686506e-06 -1.009342e-05 -1.051671e-05 -1.095714e-05
## ASV0044      5.811575e-04  6.076920e-04  6.353860e-04  6.642856e-04
## ASV5490      9.091268e-05  9.485818e-05  9.895666e-05  1.032123e-04
## ASV2638      2.501649e-05  2.630180e-05  2.765319e-05  2.907374e-05
## ASV0829     -5.151590e-05 -5.347561e-05 -5.548898e-05 -5.755576e-05
## ASV0601      1.072808e-04  1.124350e-04  1.178379e-04  1.235013e-04
## ASV0234      2.521626e-04  2.635518e-04  2.754271e-04  2.878065e-04
## ASV0133      3.335843e-04  3.488727e-04  3.648344e-04  3.814968e-04
## ASV0323      3.542031e-04  3.707988e-04  3.881591e-04  4.063181e-04
## ASV0854     -2.664761e-05 -2.765896e-05 -2.869560e-05 -2.975680e-05
## ASV0110      4.479275e-04  4.686815e-04  4.903695e-04  5.130308e-04
## ASV0816      2.420227e-05  2.524115e-05  2.632033e-05  2.744110e-05
## ASV1031     -6.999291e-05 -7.302749e-05 -7.618306e-05 -7.946382e-05
## ASV0144     -1.823388e-04 -1.905642e-04 -1.991400e-04 -2.080792e-04
## ASV0020     -8.409098e-05 -8.847360e-05 -9.309841e-05 -9.797974e-05
## ASV0962     -1.492790e-04 -1.560484e-04 -1.631087e-04 -1.704711e-04
## ASV0794      2.953915e-04  3.095360e-04  3.243547e-04  3.398787e-04
## ASV7117     -1.522664e-04 -1.592611e-04 -1.665662e-04 -1.741946e-04
## ASV1008     -1.088523e-04 -1.140570e-04 -1.195103e-04 -1.252243e-04
## ASV0096      4.824937e-04  5.048663e-04  5.282472e-04  5.526792e-04
## ASV0128     -2.893292e-04 -3.031841e-04 -3.177038e-04 -3.329202e-04
## ASV5232      2.187935e-04  2.289761e-04  2.396190e-04  2.507416e-04
## ASV0031      1.355034e-05  1.388488e-05  1.420786e-05  1.451644e-05
## ASV1744     -3.332269e-05 -3.494423e-05 -3.664839e-05 -3.843984e-05
## ASV0289      2.685413e-04  2.809106e-04  2.938316e-04  3.073275e-04
## ASV7413     -6.101324e-05 -6.448216e-05 -6.815958e-05 -7.205816e-05
## ASV0822     -3.228597e-04 -3.371072e-04 -3.519338e-04 -3.673588e-04
## ASV8111     -2.722440e-04 -2.836871e-04 -2.955473e-04 -3.078347e-04
## ASV0687      2.018853e-04  2.113883e-04  2.213301e-04  2.317300e-04
## ASV0112      6.263673e-05  6.470312e-05  6.678617e-05  6.887972e-05
## ASV0987      1.627309e-04  1.704054e-04  1.784372e-04  1.868425e-04
## ASV5332     -8.878591e-05 -9.239165e-05 -9.612027e-05 -9.997432e-05
## ASV1129     -2.124931e-04 -2.223107e-04 -2.325692e-04 -2.432874e-04
## ASV1274     -6.971031e-05 -7.293594e-05 -7.630615e-05 -7.982698e-05
## ASV0119      3.930724e-04  4.112707e-04  4.302867e-04  4.501546e-04
## ASV0890      9.964891e-05  1.044107e-04  1.093993e-04  1.146252e-04
## ASV0848      5.634973e-04  5.893329e-04  6.163059e-04  6.444619e-04
## ASV5944     -2.933686e-04 -3.060254e-04 -3.191711e-04 -3.328197e-04
## ASV19741    -2.949629e-04 -3.083927e-04 -3.224065e-04 -3.370272e-04
## ASV0504     -3.376823e-04 -3.526656e-04 -3.682659e-04 -3.845049e-04
## ASV2146     -2.216333e-04 -2.315520e-04 -2.418907e-04 -2.526656e-04
## ASV0089     -1.855213e-04 -1.943242e-04 -2.035406e-04 -2.131893e-04
## ASV2301     -1.962317e-04 -2.053331e-04 -2.148447e-04 -2.247840e-04
## ASV2982      5.905712e-05  6.198665e-05  6.505959e-05  6.828227e-05
## ASV0891     -2.481851e-04 -2.595349e-04 -2.713823e-04 -2.837471e-04
## ASV0093      4.029629e-04  4.213758e-04  4.405946e-04  4.606514e-04
## ASV0042      1.905054e-04  1.989971e-04  2.078411e-04  2.170500e-04
## ASV0980      2.669341e-04  2.788446e-04  2.912502e-04  3.041684e-04
## ASV0069     -6.779994e-05 -7.115731e-05 -7.468555e-05 -7.839365e-05
## ASV1364     -4.781373e-05 -5.004529e-05 -5.237911e-05 -5.481974e-05
## ASV0524     -7.816899e-05 -8.199595e-05 -8.601375e-05 -9.023212e-05
## ASV0435      5.330811e-04  5.576270e-04  5.832637e-04  6.100362e-04
## ASV0517     -2.163915e-04 -2.262727e-04 -2.365850e-04 -2.473456e-04
## ASV3167     -9.355059e-05 -9.798096e-05 -1.026176e-04 -1.074696e-04
## ASV4280     -3.942941e-05 -4.143225e-05 -4.354216e-05 -4.576527e-05
## ASV1158      1.304129e-04  1.367608e-04  1.434172e-04  1.503965e-04
## ASV2214      1.009516e-04  1.056069e-04  1.104737e-04  1.155615e-04
## ASV0544     -1.197701e-04 -1.253145e-04 -1.311078e-04 -1.371603e-04
## ASV5326     -2.168522e-05 -2.263761e-05 -2.362849e-05 -2.465914e-05
## ASV3765     -3.104390e-04 -3.242533e-04 -3.386376e-04 -3.536116e-04
## ASV4646     -8.117708e-06 -9.026301e-06 -1.001967e-05 -1.110471e-05
## ASV0090      3.091015e-05  3.205492e-05  3.322576e-05  3.442159e-05
## ASV3680      2.925803e-04  3.052798e-04  3.184762e-04  3.321842e-04
## ASV0111      4.846846e-05  5.044778e-05  5.249256e-05  5.460355e-05
## ASV0768      1.824395e-04  1.908729e-04  1.996846e-04  2.088906e-04
## ASV4862     -1.061223e-05 -1.101987e-05 -1.143852e-05 -1.186805e-05
## ASV1742     -2.402190e-04 -2.507108e-04 -2.616213e-04 -2.729641e-04
## ASV3701     -4.232646e-05 -4.432785e-05 -4.642381e-05 -4.861885e-05
## ASV2386     -1.449230e-04 -1.514734e-04 -1.583031e-04 -1.654225e-04
## ASV0375     -3.383948e-04 -3.533516e-04 -3.689193e-04 -3.851186e-04
## ASV2796      9.030145e-05  9.424821e-05  9.835276e-05  1.026202e-04
## ASV1369      2.338628e-04  2.442348e-04  2.550352e-04  2.662791e-04
## ASV10272    -2.119592e-04 -2.214845e-04 -2.314116e-04 -2.417550e-04
## ASV10354    -2.119423e-04 -2.214660e-04 -2.313914e-04 -2.417330e-04
## ASV1067     -1.817565e-05 -1.908772e-05 -2.004718e-05 -2.105659e-05
## ASV1900      4.445308e-04  4.650215e-04  4.864245e-04  5.087774e-04
## ASV4079     -7.630415e-05 -7.991807e-05 -8.370075e-05 -8.765970e-05
## ASV4149      2.979896e-04  3.109554e-04  3.244310e-04  3.384316e-04
## ASV5140     -2.119252e-04 -2.214474e-04 -2.313711e-04 -2.417107e-04
## ASV10782    -9.525800e-06 -9.809395e-06 -1.009167e-05 -1.037137e-05
## ASV4273     -4.853930e-05 -5.054741e-05 -5.262404e-05 -5.477015e-05
## ASV8121      2.047454e-04  2.141858e-04  2.240477e-04  2.343489e-04
## ASV8438     -2.119103e-04 -2.214312e-04 -2.313534e-04 -2.416915e-04
## ASV9390     -2.118934e-04 -2.214127e-04 -2.313332e-04 -2.416695e-04
## ASV1340      2.940951e-04  3.077229e-04  3.219636e-04  3.368427e-04
## ASV2650     -3.145371e-04 -3.284861e-04 -3.430069e-04 -3.581185e-04
## ASV4674      1.613173e-04  1.686836e-04  1.763715e-04  1.843936e-04
## ASV10492    -1.394615e-05 -1.463915e-05 -1.536767e-05 -1.613362e-05
## ASV11430    -2.118682e-04 -2.213852e-04 -2.313033e-04 -2.416369e-04
## ASV12135    -2.118512e-04 -2.213667e-04 -2.312831e-04 -2.416149e-04
## ASV14970    -2.118343e-04 -2.213482e-04 -2.312629e-04 -2.415928e-04
## ASV1954      2.419177e-04  2.529639e-04  2.644916e-04  2.765199e-04
## ASV2613      3.779202e-04  3.950784e-04  4.129771e-04  4.316449e-04
## ASV2757      1.491455e-04  1.556288e-04  1.623665e-04  1.693663e-04
## ASV2909     -2.215320e-04 -2.316978e-04 -2.423116e-04 -2.533916e-04
## ASV2954     -4.248567e-05 -4.426914e-05 -4.611594e-05 -4.802723e-05
## ASV2969      2.091422e-04  2.189185e-04  2.291423e-04  2.398331e-04
## ASV3410      4.514280e-05  4.744360e-05  4.986703e-05  5.241998e-05
## ASV3575      1.111376e-04  1.162435e-04  1.215764e-04  1.271457e-04
## ASV4275      2.403563e-04  2.508732e-04  2.618084e-04  2.731747e-04
## ASV4652      4.257514e-05  4.474825e-05  4.703659e-05  4.944646e-05
## ASV4761      2.401430e-04  2.506652e-04  2.616064e-04  2.729796e-04
## ASV6003      1.867243e-04  1.956421e-04  2.049859e-04  2.147758e-04
## ASV6110     -2.118710e-04 -2.213884e-04 -2.313069e-04 -2.416409e-04
## ASV7427      1.387102e-04  1.450478e-04  1.516627e-04  1.585659e-04
## ASV8092     -2.118601e-04 -2.213765e-04 -2.312939e-04 -2.416269e-04
## ASV8169     -2.118432e-04 -2.213580e-04 -2.312738e-04 -2.416048e-04
## ASV9693      9.277024e-05  9.703519e-05  1.014889e-04  1.061391e-04
## ASV10913     1.024880e-04  1.073775e-04  1.124995e-04  1.178649e-04
## ASV1979     -3.450302e-05 -3.599977e-05 -3.755497e-05 -3.917036e-05
## ASV3772      2.627531e-04  2.745363e-04  2.868157e-04  2.996092e-04
## ASV0113      4.937229e-05  5.139594e-05  5.348640e-05  5.564430e-05
## ASV1800     -2.266725e-05 -2.376550e-05 -2.491624e-05 -2.612181e-05
## ASV2335     -2.659000e-04 -2.770873e-04 -2.886832e-04 -3.006976e-04
## ASV0692      9.148860e-05  9.576472e-05  1.002361e-04  1.049111e-04
## ASV1120      1.152667e-04  1.205145e-04  1.259900e-04  1.317018e-04
## ASV1434     -6.114278e-04 -6.392887e-04 -6.683618e-04 -6.986945e-04
## ASV0076     -7.122478e-05 -7.473565e-05 -7.842385e-05 -8.229859e-05
## ASV0361      4.634303e-04  4.848714e-04  5.072743e-04  5.306794e-04
## ASV2231     -1.563942e-04 -1.641756e-04 -1.723554e-04 -1.809545e-04
## ASV2018     -1.310835e-05 -1.404925e-05 -1.506351e-05 -1.615709e-05
## ASV1529      3.847518e-04  4.026792e-04  4.214227e-04  4.410177e-04
## ASV0841     -1.919253e-05 -1.993278e-05 -2.069298e-05 -2.147281e-05
## ASV2556     -2.308958e-04 -2.413123e-04 -2.521718e-04 -2.634909e-04
## ASV2777      2.912301e-04  3.038581e-04  3.169788e-04  3.306066e-04
## ASV0355      2.402323e-04  2.513970e-04  2.630679e-04  2.752669e-04
## ASV5169     -3.281573e-04 -3.430090e-04 -3.584968e-04 -3.746447e-04
## ASV3091      1.613347e-04  1.689955e-04  1.770179e-04  1.854188e-04
## ASV2435      2.315254e-04  2.419143e-04  2.527393e-04  2.640161e-04
## ASV6822     -1.495108e-04 -1.562301e-04 -1.632327e-04 -1.705289e-04
## ASV12605    -3.582967e-04 -3.745438e-04 -3.914899e-04 -4.091617e-04
## ASV0286     -2.396834e-04 -2.505745e-04 -2.619386e-04 -2.737946e-04
## ASV0074     -1.528271e-05 -1.654049e-05 -1.790427e-05 -1.938285e-05
## ASV2485     -9.503865e-06 -9.717723e-06 -9.922535e-06 -1.011652e-05
## ASV1233     -4.583325e-04 -4.793717e-04 -5.013413e-04 -5.242794e-04
## ASV0356     -2.186400e-04 -2.284412e-04 -2.386557e-04 -2.492985e-04
## ASV2918     -2.639547e-04 -2.752582e-04 -2.869907e-04 -2.991638e-04
## ASV1427     -4.731059e-07 -6.328769e-07 -8.124440e-07 -1.013773e-06
## ASV1409      2.689510e-04  2.816490e-04  2.949409e-04  3.088538e-04
## ASV0770      8.187379e-05  8.518200e-05  8.859356e-05  9.210859e-05
## ASV1403     -3.216491e-04 -3.362546e-04 -3.514907e-04 -3.673817e-04
## ASV0314     -1.746592e-04 -1.826569e-04 -1.910051e-04 -1.997180e-04
## ASV0187      3.238396e-06  3.099425e-06  2.930160e-06  2.727493e-06
## ASV0313     -2.331715e-04 -2.435384e-04 -2.543329e-04 -2.655698e-04
## ASV1087      4.077835e-04  4.265707e-04  4.461942e-04  4.666887e-04
## ASV1970      2.137785e-05  2.220839e-05  2.306187e-05  2.393801e-05
## ASV0754      3.281411e-04  3.432584e-04  3.590489e-04  3.755405e-04
## ASV3775     -2.238817e-04 -2.343356e-04 -2.452674e-04 -2.566980e-04
## ASV0132      9.135582e-05  9.536539e-05  9.953455e-05  1.038681e-04
## ASV2329     -6.481532e-05 -6.836504e-05 -7.211964e-05 -7.609117e-05
## ASV0561      2.796433e-04  2.921096e-04  3.050927e-04  3.186103e-04
## ASV0130     -3.429945e-04 -3.587266e-04 -3.751513e-04 -3.922965e-04
## ASV0226      3.890628e-04  4.068595e-04  4.254360e-04  4.448232e-04
## ASV12648    -2.758481e-04 -2.882813e-04 -3.012460e-04 -3.147626e-04
## ASV0204      3.878284e-04  4.055616e-04  4.240711e-04  4.433876e-04
## ASV0767      6.401753e-05  6.651039e-05  6.907213e-05  7.170177e-05
## ASV0335     -2.125420e-04 -2.223436e-04 -2.325815e-04 -2.432736e-04
## ASV5901     -6.300577e-05 -6.560606e-05 -6.829675e-05 -7.107960e-05
## ASV0596     -8.124228e-05 -8.453961e-05 -8.794355e-05 -9.145497e-05
## ASV9271      8.013834e-05  8.430939e-05  8.870579e-05  9.333983e-05
## ASV0904      3.420538e-04  3.578321e-04  3.743143e-04  3.915295e-04
## ASV15270    -8.959143e-05 -9.398043e-05 -9.858321e-05 -1.034096e-04
## ASV0990     -9.913349e-05 -1.038735e-04 -1.088402e-04 -1.140444e-04
## ASV0155     -2.056383e-04 -2.149533e-04 -2.246684e-04 -2.347988e-04
## ASV0086     -8.371201e-07 -7.854451e-07 -7.233996e-07 -6.498595e-07
## ASV2581     -1.219031e-05 -1.246344e-05 -1.272153e-05 -1.296142e-05
## ASV1579     -2.435453e-04 -2.550837e-04 -2.671639e-04 -2.798108e-04
## ASV7730     -1.047150e-05 -1.139126e-05 -1.238714e-05 -1.346481e-05
## ASV0897      9.959441e-05  1.041983e-04  1.090083e-04  1.140330e-04
## ASV1975      4.675894e-04  4.889023e-04  5.111434e-04  5.343493e-04
## ASV0759     -1.108329e-05 -1.149587e-05 -1.191828e-05 -1.235023e-05
## ASV3082     -2.839776e-04 -2.970268e-04 -3.106538e-04 -3.248820e-04
## ASV3195     -4.960637e-04 -5.191826e-04 -5.433552e-04 -5.686276e-04
## ASV0427      2.604027e-04  2.725776e-04  2.853106e-04  2.986260e-04
## ASV2674      5.362090e-05  5.593577e-05  5.833792e-05  6.082935e-05
## ASV1500      8.065648e-05  8.432860e-05  8.816075e-05  9.215929e-05
## ASV0102     -2.981046e-04 -3.121283e-04 -3.268028e-04 -3.421573e-04
## ASV1217     -7.471467e-05 -7.793297e-05 -8.127348e-05 -8.473930e-05
## ASV4998     -3.122944e-05 -3.265445e-05 -3.414131e-05 -3.569240e-05
## ASV2890      4.240303e-04  4.431021e-04  4.629812e-04  4.836974e-04
## ASV0672     -1.845288e-04 -1.930420e-04 -2.019355e-04 -2.112251e-04
## ASV6960     -1.675698e-04 -1.756885e-04 -1.841997e-04 -1.931215e-04
## ASV0821      2.751171e-04  2.873366e-04  3.000603e-04  3.133058e-04
## ASV1995     -2.634285e-04 -2.755696e-04 -2.882511e-04 -3.014952e-04
## ASV0211     -1.488412e-04 -1.560818e-04 -1.636777e-04 -1.716463e-04
## ASV0364      1.538906e-04  1.610243e-04  1.684798e-04  1.762709e-04
## ASV3616      3.287262e-04  3.430085e-04  3.578509e-04  3.732700e-04
## ASV1996      3.724293e-04  3.893823e-04  4.070732e-04  4.255313e-04
## ASV1881     -6.060156e-05 -6.343618e-05 -6.640071e-05 -6.950083e-05
## ASV1089      3.630744e-04  3.796011e-04  3.968445e-04  4.148322e-04
## ASV1450     -7.441057e-05 -7.769884e-05 -8.112077e-05 -8.468076e-05
## ASV4643     -2.073274e-04 -2.167378e-04 -2.265536e-04 -2.367903e-04
## ASV3458      1.023879e-04  1.071690e-04  1.121636e-04  1.173801e-04
## ASV2543     -9.126839e-05 -9.563457e-05 -1.002097e-04 -1.050037e-04
## ASV3306     -1.034537e-04 -1.082799e-04 -1.133212e-04 -1.185861e-04
## ASV0218     -2.024545e-04 -2.117977e-04 -2.215592e-04 -2.317564e-04
## ASV3727      1.360409e-04  1.426181e-04  1.495159e-04  1.567501e-04
## ASV4394     -1.466610e-04 -1.536293e-04 -1.609261e-04 -1.685663e-04
## ASV2636      1.219656e-05  1.334955e-05  1.460764e-05  1.597996e-05
## ASV5116      3.648535e-05  3.809414e-05  3.976803e-05  4.150916e-05
## ASV1394     -3.603366e-04 -3.769316e-04 -3.942648e-04 -4.123669e-04
## ASV0656     -3.530867e-04 -3.690585e-04 -3.857142e-04 -4.030796e-04
## ASV0475      5.373466e-04  5.622144e-04  5.881989e-04  6.153470e-04
## ASV1042      1.341185e-04  1.402841e-04  1.467221e-04  1.534436e-04
## ASV1199     -2.774215e-04 -2.903599e-04 -3.038890e-04 -3.180347e-04
## ASV12962    -1.843943e-05 -1.920321e-05 -1.999337e-05 -2.081035e-05
## ASV0853      2.511804e-04  2.626316e-04  2.745786e-04  2.870402e-04
## ASV5069     -5.813901e-05 -6.155883e-05 -6.519320e-05 -6.905589e-05
## ASV7825     -1.567972e-04 -1.640228e-04 -1.715696e-04 -1.794507e-04
## ASV0339      1.756470e-04  1.837385e-04  1.921904e-04  2.010177e-04
## ASV2965      1.530131e-04  1.600861e-04  1.674756e-04  1.751947e-04
## ASV2347     -2.028631e-04 -2.119099e-04 -2.213331e-04 -2.311460e-04
## ASV0541      8.942692e-05  9.384075e-05  9.847713e-05  1.033475e-04
## ASV0369      2.380198e-04  2.488426e-04  2.601339e-04  2.719119e-04
## ASV0171      1.205415e-04  1.261011e-04  1.319099e-04  1.379783e-04
## ASV2235      2.885262e-04  3.010753e-04  3.141185e-04  3.276710e-04
## ASV5809     -2.712410e-04 -2.834958e-04 -2.962736e-04 -3.095940e-04
## ASV1267      3.417797e-04  3.573227e-04  3.735377e-04  3.904506e-04
## ASV0207     -3.679421e-04 -3.846024e-04 -4.019768e-04 -4.200921e-04
## ASV3126     -4.356532e-04 -4.558927e-04 -4.770478e-04 -4.991577e-04
## ASV0183     -4.799220e-04 -5.018772e-04 -5.247955e-04 -5.487153e-04
## ASV1792      1.642200e-04  1.715277e-04  1.791367e-04  1.870575e-04
## ASV2001     -4.236664e-04 -4.434146e-04 -4.640634e-04 -4.856523e-04
## ASV5732     -4.162793e-04 -4.353217e-04 -4.551983e-04 -4.759425e-04
## ASV2857     -2.638658e-04 -2.760957e-04 -2.888770e-04 -3.022333e-04
## ASV1052     -1.920801e-04 -2.007350e-04 -2.097592e-04 -2.191670e-04
## ASV3226     -1.223972e-04 -1.280224e-04 -1.338967e-04 -1.400301e-04
## ASV3766     -4.526420e-05 -4.737247e-05 -4.957685e-05 -5.188154e-05
## ASV0982     -1.325310e-04 -1.388877e-04 -1.455501e-04 -1.525329e-04
## ASV0489     -3.215186e-06 -3.743575e-06 -4.329428e-06 -4.978046e-06
## ASV3990     -4.529840e-04 -4.739765e-04 -4.959146e-04 -5.188383e-04
## ASV0433     -2.685638e-04 -2.806098e-04 -2.931610e-04 -3.062350e-04
## ASV0684     -1.161707e-04 -1.217552e-04 -1.276107e-04 -1.337505e-04
## ASV0063     -3.179819e-04 -3.325364e-04 -3.477286e-04 -3.635837e-04
## ASV1399      5.392888e-05  5.594452e-05  5.800665e-05  6.011324e-05
## ASV3093     -5.398962e-04 -5.650752e-04 -5.914036e-04 -6.189317e-04
## ASV1771      6.626000e-05  6.947301e-05  7.284340e-05  7.637894e-05
## ASV7910     -2.716424e-04 -2.834171e-04 -2.956511e-04 -3.083579e-04
## ASV3718     -3.612344e-04 -3.778501e-04 -3.952026e-04 -4.133222e-04
## ASV0039     -2.846045e-04 -2.980533e-04 -3.121296e-04 -3.268616e-04
## ASV6469     -5.902116e-04 -6.171542e-04 -6.452719e-04 -6.746109e-04
## ASV8186     -3.998171e-04 -4.181961e-04 -4.373893e-04 -4.574300e-04
## ASV1091     -4.081142e-05 -4.279980e-05 -4.488646e-05 -4.707630e-05
## ASV16930    -4.888708e-04 -5.114153e-04 -5.349649e-04 -5.595612e-04
## ASV7234     -3.660635e-04 -3.829167e-04 -4.005187e-04 -4.189004e-04
## ASV1560     -4.405046e-05 -4.614341e-05 -4.833513e-05 -5.063018e-05
## ASV2968      7.412694e-05  7.773057e-05  8.151207e-05  8.548041e-05
## ASV3824     -3.763088e-04 -3.934817e-04 -4.114041e-04 -4.301058e-04
## ASV0442     -2.347728e-04 -2.456821e-04 -2.570851e-04 -2.690031e-04
## ASV0677     -1.783220e-04 -1.860448e-04 -1.940676e-04 -2.023990e-04
## ASV4796     -2.503128e-04 -2.615908e-04 -2.733495e-04 -2.856071e-04
## ASV2206     -3.996191e-04 -4.180871e-04 -4.373824e-04 -4.575393e-04
## ASV2884      7.962277e-05  8.330764e-05  8.715776e-05  9.118003e-05
## ASV0482     -1.450710e-04 -1.518222e-04 -1.588802e-04 -1.662583e-04
## ASV1273      3.320555e-04  3.475114e-04  3.636663e-04  3.805498e-04
## ASV1910      4.389843e-05  4.565427e-05  4.746446e-05  4.932919e-05
## ASV0105      2.512557e-04  2.624045e-04  2.740107e-04  2.860898e-04
## ASV0149      2.665521e-04  2.788099e-04  2.916109e-04  3.049771e-04
## ASV5007     -4.152913e-04 -4.345107e-04 -4.545930e-04 -4.755746e-04
## ASV0757      3.586484e-04  3.753049e-04  3.927152e-04  4.109116e-04
## ASV11952    -2.972381e-04 -3.106513e-04 -3.246351e-04 -3.392107e-04
## ASV4102      2.367313e-04  2.476968e-04  2.591551e-04  2.711269e-04
## ASV1034      2.986139e-04  3.122011e-04  3.263784e-04  3.411687e-04
## ASV0753      2.217601e-04  2.319282e-04  2.425446e-04  2.536276e-04
## ASV2323      1.344966e-04  1.407901e-04  1.473723e-04  1.542561e-04
## ASV0881     -1.048396e-04 -1.095086e-04 -1.143699e-04 -1.194300e-04
## ASV3730     -2.783955e-04 -2.911344e-04 -3.044318e-04 -3.183102e-04
## ASV2685     -1.066670e-04 -1.113098e-04 -1.161339e-04 -1.211444e-04
## ASV3826     -5.271110e-05 -5.514531e-05 -5.768904e-05 -6.034701e-05
## ASV0689      2.444436e-05  2.579460e-05  2.722539e-05  2.874188e-05
## ASV4315     -3.646890e-04 -3.815853e-04 -3.992425e-04 -4.176930e-04
## ASV1239      1.759447e-04  1.834716e-04  1.912835e-04  1.993882e-04
## ASV3147     -6.064987e-05 -6.356098e-05 -6.661232e-05 -6.981064e-05
## ASV3454     -2.720866e-04 -2.845268e-04 -2.975121e-04 -3.110645e-04
## ASV4411     -1.621854e-04 -1.698832e-04 -1.779452e-04 -1.863884e-04
## ASV3007      3.253706e-04  3.399988e-04  3.552446e-04  3.711305e-04
## ASV6151     -2.638605e-04 -2.756067e-04 -2.878405e-04 -3.005789e-04
## ASV0834      2.773660e-04  2.903114e-04  3.038477e-04  3.180006e-04
## ASV1231      3.981241e-04  4.163891e-04  4.354593e-04  4.553673e-04
## ASV0643      3.356515e-04  3.510273e-04  3.670788e-04  3.838329e-04
## ASV0924      9.720892e-06  1.017024e-05  1.063858e-05  1.112647e-05
## ASV3238     -1.657768e-04 -1.732055e-04 -1.809456e-04 -1.890081e-04
## ASV1276     -1.951464e-04 -2.040765e-04 -2.133981e-04 -2.231268e-04
## ASV5503     -5.278275e-04 -5.518331e-04 -5.768774e-04 -6.030005e-04
## ASV0404      2.125463e-04  2.224364e-04  2.327751e-04  2.435819e-04
## ASV3430      3.238844e-05  3.448537e-05  3.673048e-05  3.913474e-05
## ASV5401     -2.256141e-04 -2.360576e-04 -2.469703e-04 -2.583719e-04
## ASV3426     -4.809037e-04 -5.028844e-04 -5.258268e-04 -5.497692e-04
## ASV0777      2.862061e-04  2.993112e-04  3.129920e-04  3.272714e-04
## ASV11093    -1.923986e-04 -2.012226e-04 -2.104360e-04 -2.200544e-04
## ASV2170     -1.673982e-04 -1.748927e-04 -1.827006e-04 -1.908329e-04
## ASV3861      1.517405e-04  1.583653e-04  1.652515e-04  1.724069e-04
## ASV1723     -2.798588e-04 -2.927731e-04 -3.062637e-04 -3.203544e-04
## ASV2460     -1.585301e-04 -1.659229e-04 -1.736526e-04 -1.817339e-04
## ASV1218     -2.297508e-04 -2.400918e-04 -2.508712e-04 -2.621052e-04
## ASV0436      1.460840e-05  1.498334e-05  1.534804e-05  1.569969e-05
## ASV0919      1.958296e-04  2.047073e-04  2.139672e-04  2.236239e-04
## ASV0577      8.376455e-05  8.753873e-05  9.147284e-05  9.557272e-05
## ASV2517      2.227418e-04  2.327779e-04  2.432395e-04  2.541421e-04
## ASV2628     -2.709189e-04 -2.834810e-04 -2.966084e-04 -3.103247e-04
## ASV1743     -2.471653e-04 -2.587390e-04 -2.708445e-04 -2.835054e-04
## ASV1678     -2.132036e-04 -2.232670e-04 -2.338006e-04 -2.448257e-04
## ASV0315      2.777224e-04  2.905630e-04  3.039792e-04  3.179953e-04
## ASV0253      1.294541e-04  1.353518e-04  1.415053e-04  1.479244e-04
## ASV1363      3.511679e-04  3.668381e-04  3.831583e-04  4.001513e-04
## ASV0995     -1.934800e-04 -2.024300e-04 -2.117817e-04 -2.215521e-04
## ASV4185     -8.468215e-05 -8.834085e-05 -9.214088e-05 -9.608626e-05
## ASV0782      1.762977e-04  1.846433e-04  1.933816e-04  2.025308e-04
## ASV3240     -2.097738e-04 -2.195581e-04 -2.297893e-04 -2.404870e-04
## ASV1392     -3.805920e-04 -3.982891e-04 -4.167891e-04 -4.361268e-04
## ASV8488     -8.654984e-05 -9.058600e-05 -9.480700e-05 -9.922104e-05
## ASV2814     -1.411309e-04 -1.476749e-04 -1.545147e-04 -1.616631e-04
## ASV0678     -2.873592e-04 -3.009961e-04 -3.152769e-04 -3.302317e-04
## ASV1295     -2.009942e-04 -2.102756e-04 -2.199723e-04 -2.301016e-04
## ASV7517     -1.220765e-04 -1.274655e-04 -1.330730e-04 -1.389062e-04
## ASV2996     -3.917015e-04 -4.095676e-04 -4.282118e-04 -4.476647e-04
## ASV2882     -3.680372e-04 -3.847172e-04 -4.021147e-04 -4.202572e-04
## ASV1317      2.266114e-04  2.371119e-04  2.480845e-04  2.595491e-04
## ASV9106     -3.743984e-04 -3.916772e-04 -4.097277e-04 -4.285817e-04
## ASV9688     -3.562899e-04 -3.727221e-04 -3.898866e-04 -4.078137e-04
## ASV6181     -3.555752e-04 -3.719214e-04 -3.889914e-04 -4.068149e-04
## ASV2936      1.059411e-05  1.118363e-05  1.180848e-05  1.247091e-05
## ASV0192     -1.467234e-04 -1.532242e-04 -1.599893e-04 -1.670272e-04
## ASV2509     -1.796028e-04 -1.881349e-04 -1.970697e-04 -2.064259e-04
## ASV0863      6.222772e-04  6.501600e-04  6.792125e-04  7.094768e-04
## ASV2762     -1.600588e-04 -1.674644e-04 -1.752033e-04 -1.832896e-04
## ASV4904     -3.406754e-04 -3.563385e-04 -3.726954e-04 -3.897745e-04
## ASV0571      1.163590e-04  1.216008e-04  1.270667e-04  1.327654e-04
## ASV13304    -5.443625e-05 -5.728038e-05 -6.028133e-05 -6.344821e-05
## ASV6863     -7.730077e-05 -8.088047e-05 -8.462197e-05 -8.853228e-05
## ASV4844      2.861515e-05  3.026207e-05  3.201290e-05  3.387475e-05
## ASV10779    -3.739712e-04 -3.910741e-04 -4.089260e-04 -4.275569e-04
## ASV7921     -3.156582e-04 -3.302205e-04 -3.454327e-04 -3.613219e-04
## ASV8458     -3.292389e-04 -3.441571e-04 -3.597158e-04 -3.759393e-04
## ASV2593     -4.443933e-05 -4.615884e-05 -4.792452e-05 -4.973551e-05
## ASV4410     -1.789707e-04 -1.872638e-04 -1.959299e-04 -2.049849e-04
## ASV0593      4.594720e-04  4.810661e-04  5.036579e-04  5.272916e-04
## ASV2669      2.679113e-04  2.799443e-04  2.924837e-04  3.055476e-04
## ASV0868     -3.516973e-04 -3.679103e-04 -3.848455e-04 -4.025330e-04
## ASV3123     -1.240552e-04 -1.300067e-04 -1.362426e-04 -1.427762e-04
## ASV3482     -1.431660e-04 -1.496830e-04 -1.564824e-04 -1.635750e-04
## ASV2552     -3.954723e-04 -4.129599e-04 -4.311599e-04 -4.500957e-04
## ASV0723      4.503419e-04  4.702968e-04  4.910683e-04  5.126840e-04
## ASV0526     -2.992216e-04 -3.130009e-04 -3.273939e-04 -3.424262e-04
## ASV4623     -1.352024e-04 -1.415049e-04 -1.480944e-04 -1.549832e-04
## ASV2070     -4.170980e-04 -4.362469e-04 -4.562415e-04 -4.771163e-04
## ASV1198      1.059472e-05  1.103229e-05  1.148462e-05  1.195186e-05
## ASV3034      1.736810e-05  1.806492e-05  1.878388e-05  1.952518e-05
## ASV1208     -4.948317e-05 -5.173667e-05 -5.408842e-05 -5.654233e-05
## ASV4860      6.766922e-05  7.086185e-05  7.420279e-05  7.769863e-05
## ASV2493     -1.291720e-04 -1.351206e-04 -1.413341e-04 -1.478233e-04
## ASV4217     -8.892701e-05 -9.278177e-05 -9.678530e-05 -1.009416e-04
## ASV1516     -5.674314e-05 -5.977742e-05 -6.298561e-05 -6.637841e-05
## ASV1186      1.542537e-04  1.613688e-04  1.688014e-04  1.765647e-04
## ASV1906     -1.342075e-04 -1.404460e-04 -1.469674e-04 -1.537841e-04
## ASV8220     -2.119107e-05 -2.235408e-05 -2.358630e-05 -2.489221e-05
## ASV4227     -3.059067e-04 -3.199616e-04 -3.346385e-04 -3.499626e-04
## ASV1013      1.922120e-04  2.013778e-04  2.109785e-04  2.210342e-04
## ASV7952     -2.077605e-04 -2.176665e-04 -2.280438e-04 -2.389145e-04
## ASV5923     -2.362398e-04 -2.472471e-04 -2.587557e-04 -2.707870e-04
## ASV0190     -2.930026e-04 -3.062544e-04 -3.200728e-04 -3.344790e-04
## ASV0491     -3.226593e-05 -3.395678e-05 -3.574162e-05 -3.762605e-05
## ASV9535     -1.260873e-04 -1.318947e-04 -1.379598e-04 -1.442930e-04
## ASV9947     -9.469320e-05 -9.941293e-05 -1.043754e-04 -1.095937e-04
## ASV6518     -8.241895e-05 -8.621151e-05 -9.017262e-05 -9.430925e-05
## ASV1741     -8.482141e-05 -8.883148e-05 -9.302928e-05 -9.742335e-05
## ASV1874      1.594090e-04  1.664841e-04  1.738487e-04  1.815122e-04
## ASV2150      4.535936e-05  4.747120e-05  4.967899e-05  5.198686e-05
## ASV5262     -8.386909e-05 -8.764906e-05 -9.158950e-05 -9.569633e-05
## ASV1729     -3.025304e-04 -3.165661e-04 -3.312355e-04 -3.465655e-04
## ASV1522     -5.874854e-05 -6.183020e-05 -6.508027e-05 -6.850812e-05
## ASV3250      6.459404e-05  6.746378e-05  7.045159e-05  7.356152e-05
## ASV4338     -3.055449e-04 -3.196180e-04 -3.343171e-04 -3.496679e-04
## ASV1386      3.648621e-04  3.817374e-04  3.993696e-04  4.177904e-04
## ASV0694     -4.137662e-05 -4.346090e-05 -4.565468e-05 -4.796402e-05
## ASV2026      3.298965e-05  3.479880e-05  3.671470e-05  3.874408e-05
## ASV0191     -2.429185e-04 -2.538328e-04 -2.652069e-04 -2.770572e-04
## ASV1641      1.183989e-04  1.240099e-04  1.298833e-04  1.360310e-04
## ASV1326      5.914118e-04  6.185961e-04  6.469839e-04  6.766241e-04
## ASV4786     -1.777695e-05 -1.868551e-05 -1.964286e-05 -2.065181e-05
## ASV0342      1.487123e-04  1.557266e-04  1.630678e-04  1.707506e-04
## ASV3025     -1.718633e-04 -1.795669e-04 -1.875940e-04 -1.959562e-04
## ASV6533     -2.947172e-04 -3.080469e-04 -3.219473e-04 -3.364399e-04
## ASV1898      3.303130e-04  3.456201e-04  3.616147e-04  3.783256e-04
## ASV1940      1.873069e-04  1.959434e-04  2.049641e-04  2.143846e-04
## ASV4968     -3.420184e-04 -3.578651e-04 -3.744253e-04 -3.917292e-04
## ASV3401     -1.792725e-04 -1.875141e-04 -1.961209e-04 -2.051079e-04
## ASV3211      1.078174e-04  1.129751e-04  1.183792e-04  1.240412e-04
## ASV1489     -4.750005e-04 -4.967772e-04 -5.195120e-04 -5.432435e-04
## ASV4139     -2.785143e-04 -2.913503e-04 -3.047578e-04 -3.187606e-04
## ASV6059     -2.939501e-04 -3.075085e-04 -3.216720e-04 -3.364658e-04
## ASV0918      7.418791e-05  7.742437e-05  8.078828e-05  8.428343e-05
## ASV1449      2.856241e-04  2.987869e-04  3.125359e-04  3.268952e-04
## ASV5652     -1.962991e-04 -2.053253e-04 -2.147513e-04 -2.245935e-04
## ASV4091     -6.050586e-06 -5.962062e-06 -5.836022e-06 -5.667906e-06
## ASV7638     -1.822010e-04 -1.904508e-04 -1.990541e-04 -2.080245e-04
## ASV6525     -2.564867e-04 -2.679413e-04 -2.798744e-04 -2.923029e-04
## ASV8959     -2.654712e-04 -2.777621e-04 -2.906054e-04 -3.040243e-04
## ASV0699      2.028270e-04  2.121349e-04  2.218513e-04  2.319921e-04
## ASV2925      2.488401e-04  2.604169e-04  2.725190e-04  2.851692e-04
## ASV0618      5.502483e-05  5.771084e-05  6.052896e-05  6.348561e-05
## ASV2083      3.846607e-05  4.036148e-05  4.235245e-05  4.444392e-05
## ASV6192     -3.234459e-04 -3.382555e-04 -3.537153e-04 -3.698512e-04
## ASV8640     -3.656896e-04 -3.824490e-04 -3.999462e-04 -4.182107e-04
## ASV1103      1.500248e-04  1.567797e-04  1.638214e-04  1.711606e-04
## ASV4240     -1.773294e-05 -1.826442e-05 -1.879405e-05 -1.931955e-05
## ASV2180      9.518195e-05  9.953064e-05  1.040697e-04  1.088066e-04
## ASV9157     -2.344043e-04 -2.451187e-04 -2.563015e-04 -2.679713e-04
## ASV1307      4.603258e-04  4.816450e-04  5.039232e-04  5.272009e-04
## ASV4960     -1.146929e-04 -1.198220e-04 -1.251654e-04 -1.307305e-04
## ASV3930     -9.764181e-05 -1.020166e-04 -1.065755e-04 -1.113250e-04
## ASV1200     -2.014429e-04 -2.107905e-04 -2.205598e-04 -2.307687e-04
## ASV4676     -1.023502e-04 -1.070377e-04 -1.119313e-04 -1.170391e-04
## ASV6993     -3.802737e-04 -3.975026e-04 -4.154713e-04 -4.342077e-04
## ASV4813     -1.488843e-04 -1.557181e-04 -1.628534e-04 -1.703022e-04
## ASV4364     -4.904797e-04 -5.127607e-04 -5.360041e-04 -5.602468e-04
## ASV0141      1.946834e-04  2.030973e-04  2.118359e-04  2.209084e-04
## ASV3509      1.235583e-04  1.295519e-04  1.358405e-04  1.424387e-04
## ASV2751      2.070114e-04  2.165836e-04  2.265850e-04  2.370338e-04
## ASV4913     -2.120592e-04 -2.217367e-04 -2.318366e-04 -2.423756e-04
## ASV0138      5.253956e-04  5.495201e-04  5.747113e-04  6.010130e-04
## ASV7697     -1.476246e-04 -1.542182e-04 -1.610860e-04 -1.682376e-04
## ASV1602      7.551537e-05  7.865330e-05  8.189950e-05  8.525559e-05
## ASV5976     -2.943864e-04 -3.078718e-04 -3.219504e-04 -3.366459e-04
## ASV7525     -3.032426e-04 -3.171070e-04 -3.315788e-04 -3.466821e-04
## ASV4961      1.370264e-04  1.432714e-04  1.497871e-04  1.565841e-04
## ASV2546      3.697116e-04  3.861456e-04  4.032575e-04  4.210707e-04
## ASV0721     -2.234561e-04 -2.336865e-04 -2.443656e-04 -2.555113e-04
## ASV0542      2.053217e-04  2.147047e-04  2.244985e-04  2.347196e-04
## ASV3865      1.313919e-04  1.373020e-04  1.434617e-04  1.498803e-04
## ASV5571     -2.380777e-04 -2.486509e-04 -2.596582e-04 -2.711142e-04
## ASV6804      2.976564e-05  3.136141e-05  3.304903e-05  3.483422e-05
## ASV4424      2.206854e-04  2.308689e-04  2.415063e-04  2.526161e-04
## ASV3395      1.619901e-04  1.689709e-04  1.762197e-04  1.837440e-04
## ASV2394     -2.176214e-04 -2.276771e-04 -2.381830e-04 -2.491582e-04
## ASV8629     -2.176035e-04 -2.276575e-04 -2.381616e-04 -2.491347e-04
## ASV1018      1.970420e-04  2.061195e-04  2.156013e-04  2.255039e-04
## ASV6139     -4.410774e-04 -4.613610e-04 -4.825433e-04 -5.046608e-04
## ASV10411    -2.262491e-04 -2.366990e-04 -2.476163e-04 -2.590207e-04
## ASV3992     -8.795934e-05 -9.208502e-05 -9.640124e-05 -1.009165e-04
## ASV7131     -1.737345e-05 -1.820376e-05 -1.907410e-05 -1.998644e-05
## ASV3729     -3.703288e-05 -3.853173e-05 -4.007771e-05 -4.167091e-05
## ASV2197     -4.862328e-05 -5.080525e-05 -5.307917e-05 -5.544840e-05
## ASV2426     -2.272715e-04 -2.375335e-04 -2.482331e-04 -2.593867e-04
## ASV3669     -2.127377e-04 -2.227487e-04 -2.332250e-04 -2.441878e-04
## ASV1820      1.121533e-04  1.172453e-04  1.225565e-04  1.280954e-04
## ASV7081     -2.014078e-04 -2.107267e-04 -2.204644e-04 -2.306386e-04
## ASV7872     -2.559859e-04 -2.676412e-04 -2.798024e-04 -2.924891e-04
## ASV1670     -3.088590e-05 -3.213940e-05 -3.343282e-05 -3.476631e-05
## ASV0712      2.477654e-04  2.595993e-04  2.719976e-04  2.849871e-04
## ASV0474      3.804006e-04  3.971089e-04  4.144884e-04  4.325606e-04
## ASV1196      3.768688e-04  3.942641e-04  4.124364e-04  4.314182e-04
## ASV0845      2.369749e-04  2.477617e-04  2.590175e-04  2.707606e-04
## ASV12393    -4.805201e-04 -5.026863e-04 -5.258408e-04 -5.500244e-04
## ASV5867     -1.849071e-04 -1.934874e-04 -2.024544e-04 -2.118246e-04
## ASV17619    -6.984146e-05 -7.325333e-05 -7.683522e-05 -8.059584e-05
## ASV4686     -1.632888e-04 -1.709001e-04 -1.788586e-04 -1.871794e-04
## ASV3520     -2.659057e-04 -2.781261e-04 -2.908876e-04 -3.042124e-04
## ASV10800    -4.346428e-04 -4.547502e-04 -4.757598e-04 -4.977096e-04
## ASV2706      3.856263e-04  4.035418e-04  4.222677e-04  4.418388e-04
## ASV1227     -5.387275e-05 -5.625747e-05 -5.873939e-05 -6.132172e-05
## ASV2621      3.540920e-04  3.707543e-04  3.881903e-04  4.064348e-04
## ASV0460      7.908488e-05  8.289311e-05  8.688571e-05  9.107162e-05
## ASV1069     -2.896224e-04 -3.031124e-04 -3.172163e-04 -3.319606e-04
## ASV6939     -2.672767e-04 -2.794648e-04 -2.921837e-04 -3.054543e-04
## ASV2862     -3.714104e-04 -3.884638e-04 -4.062706e-04 -4.248613e-04
## ASV1021     -2.178200e-04 -2.276198e-04 -2.378340e-04 -2.484778e-04
## ASV3845      1.725536e-04  1.805573e-04  1.889213e-04  1.976608e-04
## ASV0732      1.512328e-04  1.583736e-04  1.658479e-04  1.736709e-04
## ASV10731     1.166184e-04  1.219111e-04  1.274316e-04  1.331887e-04
## ASV3378      1.392138e-04  1.453270e-04  1.516848e-04  1.582948e-04
## ASV7154      1.118991e-05  1.144368e-05  1.168412e-05  1.190840e-05
## ASV9876      6.480490e-05  6.788811e-05  7.111729e-05  7.449923e-05
## ASV0631      2.908798e-04  3.045288e-04  3.188084e-04  3.337469e-04
## ASV13027    -2.200189e-04 -2.303010e-04 -2.410544e-04 -2.522998e-04
## ASV2497     -2.200006e-04 -2.302809e-04 -2.410324e-04 -2.522757e-04
## ASV3966     -3.102262e-04 -3.247562e-04 -3.399550e-04 -3.558524e-04
## ASV2574      1.849807e-04  1.931947e-04  2.017454e-04  2.106443e-04
## ASV0545     -1.722253e-04 -1.803285e-04 -1.888066e-04 -1.976764e-04
## ASV8453     -1.953052e-04 -2.044237e-04 -2.139595e-04 -2.239310e-04
## ASV0221     -1.032866e-04 -1.080812e-04 -1.130925e-04 -1.183300e-04
## ASV3305      1.395233e-04  1.461256e-04  1.530378e-04  1.602745e-04
## ASV2647     -9.618270e-05 -1.004951e-04 -1.049883e-04 -1.096687e-04
## ASV5789     -4.453702e-04 -4.662280e-04 -4.880459e-04 -5.108665e-04
## ASV1731     -1.409015e-04 -1.470158e-04 -1.533685e-04 -1.599667e-04
## ASV3857      6.243441e-05  6.523770e-05  6.815924e-05  7.120334e-05
## ASV0405      2.623617e-04  2.741039e-04  2.863367e-04  2.990776e-04
## ASV0094     -3.003119e-04 -3.133388e-04 -3.268760e-04 -3.409390e-04
## ASV0158     -1.088521e-05 -1.117418e-05 -1.145785e-05 -1.173453e-05
## ASV5507     -2.626860e-04 -2.747799e-04 -2.874114e-04 -3.006029e-04
## ASV1023     -2.328943e-06 -2.113143e-06 -1.857235e-06 -1.556682e-06
## ASV0488     -1.708276e-04 -1.787210e-04 -1.869675e-04 -1.955819e-04
## ASV1459      1.435521e-04  1.499153e-04  1.565396e-04  1.634341e-04
## ASV4349     -4.316520e-05 -4.498080e-05 -4.686154e-05 -4.880872e-05
## ASV1172      4.429731e-04  4.631733e-04  4.842529e-04  5.062466e-04
## ASV10187    -1.162799e-04 -1.217905e-04 -1.275608e-04 -1.336027e-04
## ASV7227      6.880831e-05  7.203721e-05  7.541538e-05  7.894950e-05
## ASV10340     6.745836e-05  7.068529e-05  7.406713e-05  7.761135e-05
## ASV10821    -1.254660e-04 -1.312301e-04 -1.372490e-04 -1.435329e-04
## ASV13810    -1.254558e-04 -1.312189e-04 -1.372367e-04 -1.435194e-04
## ASV3230     -1.007481e-04 -1.053900e-04 -1.102383e-04 -1.153013e-04
## ASV5524      1.051781e-05  1.091420e-05  1.132008e-05  1.173509e-05
## ASV8742     -1.254379e-04 -1.311993e-04 -1.372153e-04 -1.434960e-04
## ASV9188      2.770735e-04  2.894577e-04  3.023574e-04  3.157907e-04
## ASV4658      1.403870e-04  1.468503e-04  1.536004e-04  1.606491e-04
## ASV7889      1.710130e-04  1.785577e-04  1.864089e-04  1.945769e-04
## ASV1466      3.973366e-05  4.186030e-05  4.410853e-05  4.648578e-05
## ASV1424     -8.091235e-05 -8.409428e-05 -8.736755e-05 -9.073136e-05
## ASV0098     -2.159594e-04 -2.260618e-04 -2.366268e-04 -2.476745e-04
## ASV0067     -3.453522e-04 -3.612501e-04 -3.778538e-04 -3.951924e-04
## ASV9434     -1.433998e-04 -1.499585e-04 -1.568045e-04 -1.639492e-04
## ASV3270     -5.664916e-05 -5.935206e-05 -6.218324e-05 -6.514864e-05
## ASV4518     -2.456747e-04 -2.568269e-04 -2.684597e-04 -2.805918e-04
## ASV7661     -2.311421e-04 -2.414540e-04 -2.521940e-04 -2.633768e-04
## ASV4223      2.638954e-05  2.763579e-05  2.893975e-05  3.030392e-05
## ASV3481      1.970925e-04  2.066856e-04  2.167536e-04  2.273206e-04
## ASV7819     -3.626931e-04 -3.793805e-04 -3.968087e-04 -4.150081e-04
## ASV3095     -1.550249e-05 -1.614924e-05 -1.681805e-05 -1.750911e-05
## ASV4476     -7.447354e-05 -7.800774e-05 -8.170887e-05 -8.558472e-05
## ASV1713      2.188264e-04  2.285234e-04  2.386172e-04  2.491211e-04
## ASV11165    -5.719912e-05 -5.967613e-05 -6.224839e-05 -6.491841e-05
## ASV2179      4.493305e-04  4.700566e-04  4.917069e-04  5.143197e-04
## ASV3747      3.852141e-04  4.029636e-04  4.215025e-04  4.408632e-04
## ASV1410      2.076503e-05  2.150888e-05  2.226667e-05  2.303730e-05
## ASV6069     -2.419838e-04 -2.531494e-04 -2.648136e-04 -2.769970e-04
## ASV1939      6.710804e-05  7.034203e-05  7.373299e-05  7.728858e-05
## ASV7865     -3.771808e-04 -3.945488e-04 -4.126881e-04 -4.316304e-04
## ASV4488     -3.466043e-04 -3.627412e-04 -3.796118e-04 -3.972479e-04
## ASV0938      2.741117e-04  2.866769e-04  2.997952e-04  3.134890e-04
## ASV7852     -2.081687e-04 -2.175901e-04 -2.274157e-04 -2.376609e-04
## ASV2503     -1.937169e-05 -2.044437e-05 -2.158234e-05 -2.279002e-05
## ASV2993     -2.968190e-04 -3.106095e-04 -3.250240e-04 -3.400892e-04
## ASV3752     -3.665321e-05 -3.829555e-05 -4.000677e-05 -4.178937e-05
## ASV2557     -3.023853e-04 -3.164491e-04 -3.311495e-04 -3.465136e-04
## ASV6522     -6.256878e-05 -6.536802e-05 -6.828405e-05 -7.132098e-05
## ASV0088     -2.249750e-04 -2.348161e-04 -2.450476e-04 -2.556815e-04
## ASV7935     -1.873286e-04 -1.958981e-04 -2.048434e-04 -2.141794e-04
## ASV0942     -2.384518e-04 -2.495419e-04 -2.611346e-04 -2.732514e-04
## ASV7709     -2.794388e-04 -2.919876e-04 -3.050649e-04 -3.186899e-04
## ASV4588     -1.431605e-04 -1.494565e-04 -1.560060e-04 -1.628172e-04
## ASV5765     -3.981767e-04 -4.164384e-04 -4.355047e-04 -4.554081e-04
## ASV3562     -2.049483e-05 -2.123260e-05 -2.198377e-05 -2.274707e-05
## ASV9076     -3.044013e-04 -3.184426e-04 -3.331105e-04 -3.484308e-04
## ASV4707     -3.396030e-04 -3.553092e-04 -3.717197e-04 -3.888641e-04
## ASV2188      2.417170e-04  2.530435e-04  2.648920e-04  2.772854e-04
## ASV0613      4.486075e-05  4.713347e-05  4.952487e-05  5.204124e-05
## ASV0663     -1.530449e-04 -1.601487e-04 -1.675735e-04 -1.753331e-04
## ASV3361     -3.040553e-04 -3.173272e-04 -3.311242e-04 -3.454624e-04
## ASV1478      3.372752e-04  3.526024e-04  3.685920e-04  3.852695e-04
## ASV0213      1.873545e-04  1.959001e-04  2.048180e-04  2.141228e-04
## ASV7674     -1.025581e-04 -1.071780e-04 -1.119942e-04 -1.170139e-04
## ASV2137     -1.099607e-04 -1.148765e-04 -1.199970e-04 -1.253296e-04
## ASV8246     -9.157437e-05 -9.572810e-05 -1.000610e-04 -1.045799e-04
## ASV0047     -2.903078e-04 -3.034021e-04 -3.170533e-04 -3.312822e-04
## ASV6117      9.851441e-06  1.041563e-05  1.101467e-05  1.165084e-05
## ASV3349     -5.545730e-05 -5.801578e-05 -6.068837e-05 -6.347980e-05
## ASV10881    -1.900949e-04 -1.988504e-04 -2.079949e-04 -2.175442e-04
## ASV6979     -1.284104e-04 -1.344023e-04 -1.406678e-04 -1.472187e-04
## ASV7930     -2.485964e-04 -2.599815e-04 -2.718669e-04 -2.842728e-04
## ASV7322      8.342640e-05  8.729582e-05  9.133958e-05  9.556505e-05
## ASV4927     -4.209192e-05 -4.413012e-05 -4.626795e-05 -4.851029e-05
## ASV9054     -1.388774e-04 -1.451827e-04 -1.517606e-04 -1.586217e-04
## ASV2692     -1.076142e-04 -1.128443e-04 -1.183287e-04 -1.240795e-04
## ASV1666     -7.386776e-05 -7.695592e-05 -8.015260e-05 -8.345966e-05
## ASV4728      1.596028e-04  1.667617e-04  1.742222e-04  1.819953e-04
## ASV3097      1.063177e-04  1.113312e-04  1.165785e-04  1.220704e-04
## ASV4962     -8.542554e-05 -8.965149e-05 -9.409165e-05 -9.875716e-05
## ASV5057      1.303637e-04  1.365473e-04  1.430229e-04  1.498040e-04
## ASV2639      2.358191e-04  2.469564e-04  2.586143e-04  2.708165e-04
## ASV1808     -2.813742e-05 -2.984351e-05 -3.166183e-05 -3.360012e-05
## ASV6333     -4.445617e-05 -4.674495e-05 -4.915790e-05 -5.170219e-05
## ASV4328     -1.056029e-04 -1.104504e-04 -1.155118e-04 -1.207958e-04
## ASV7707     -3.109029e-04 -3.250125e-04 -3.397296e-04 -3.550775e-04
## ASV11022    -3.016586e-04 -3.153047e-04 -3.295348e-04 -3.443709e-04
## ASV1469     -5.640988e-05 -5.896103e-05 -6.162162e-05 -6.439582e-05
## ASV3919     -1.040182e-04 -1.089498e-04 -1.141132e-04 -1.195191e-04
## ASV4038     -2.110610e-04 -2.207175e-04 -2.307976e-04 -2.413184e-04
## ASV4048      7.545032e-05  7.914076e-05  8.301466e-05  8.708129e-05
## ASV0634      8.721141e-05  9.131922e-05  9.561872e-05  1.001187e-04
## ASV1852     -2.377189e-04 -2.490070e-04 -2.608283e-04 -2.732074e-04
## ASV2505      1.788145e-04  1.870139e-04  1.955753e-04  2.045134e-04
## ASV1762     -2.744788e-04 -2.870207e-04 -3.001112e-04 -3.137721e-04
## ASV3761     -2.329313e-04 -2.436032e-04 -2.547445e-04 -2.663738e-04
## ASV0775     -3.950600e-04 -4.131252e-04 -4.319816e-04 -4.516604e-04
## ASV10911    -2.896992e-04 -3.029150e-04 -3.167070e-04 -3.310980e-04
## ASV1339     -4.926225e-05 -5.144350e-05 -5.371329e-05 -5.607445e-05
## ASV5214     -6.600388e-05 -6.894722e-05 -7.201223e-05 -7.520303e-05
## ASV4945      7.661359e-05  8.017301e-05  8.389312e-05  8.778069e-05
## ASV5624     -6.249920e-05 -6.514229e-05 -6.788112e-05 -7.071763e-05
## ASV3429     -3.566597e-05 -3.717785e-05 -3.874580e-05 -4.037124e-05
## ASV8416     -3.343468e-05 -3.521329e-05 -3.709249e-05 -3.907829e-05
## ASV2400     -3.573774e-04 -3.738113e-04 -3.909734e-04 -4.088935e-04
## ASV3388     -1.165473e-04 -1.220743e-04 -1.278615e-04 -1.339209e-04
## ASV7089      7.269589e-05  7.583946e-05  7.910376e-05  8.249199e-05
## ASV3396     -1.190934e-04 -1.244430e-04 -1.300174e-04 -1.358244e-04
## ASV0343      1.703700e-04  1.786648e-04  1.873693e-04  1.965041e-04
## ASV5505     -2.166264e-04 -2.267189e-04 -2.372711e-04 -2.483029e-04
## ASV6721     -1.022218e-04 -1.070776e-04 -1.121631e-04 -1.174890e-04
## ASV0537      8.921090e-05  9.387365e-05  9.879385e-05  1.039865e-04
## ASV7753     -2.809623e-04 -2.939443e-04 -3.075076e-04 -3.216763e-04
## ASV5022     -2.269384e-05 -2.398585e-05 -2.535729e-05 -2.681332e-05
## ASV1073      3.924964e-04  4.106473e-04  4.296120e-04  4.494248e-04
## ASV1347     -9.151817e-07 -1.009779e-06 -1.114266e-06 -1.229684e-06
## ASV15032     1.185935e-04  1.238627e-04  1.293478e-04  1.350559e-04
## ASV18213    -9.227939e-07 -1.018072e-06 -1.123298e-06 -1.239516e-06
## ASV20691     1.004366e-04  1.051447e-04  1.100693e-04  1.152196e-04
## ASV4260     -5.161412e-05 -5.401423e-05 -5.652396e-05 -5.914820e-05
## ASV4923      8.723170e-05  9.131316e-05  9.558135e-05  1.000444e-04
## ASV7995     -9.325754e-07 -1.028781e-06 -1.135021e-06 -1.252346e-06
## ASV8960      1.758380e-04  1.838853e-04  1.922849e-04  2.010507e-04
## ASV10682     1.334488e-04  1.392422e-04  1.452605e-04  1.515101e-04
## ASV11911    -9.511883e-07 -1.049088e-06 -1.157169e-06 -1.276496e-06
## ASV14296     2.114573e-04  2.209619e-04  2.308667e-04  2.411860e-04
## ASV2314      1.213290e-04  1.273444e-04  1.336661e-04  1.403099e-04
## ASV3819      1.364979e-04  1.426374e-04  1.490352e-04  1.557007e-04
## ASV4517     -9.794186e-07 -1.079962e-06 -1.190930e-06 -1.313407e-06
## ASV8941      2.611958e-04  2.733416e-04  2.860379e-04  2.993084e-04
## ASV1444      9.927711e-07  1.094576e-06  1.206921e-06  1.330903e-06
## ASV5959      4.762853e-05  4.977539e-05  5.201252e-05  5.434306e-05
## ASV3623     -1.205909e-04 -1.260341e-04 -1.317097e-04 -1.376267e-04
## ASV0260      1.455987e-04  1.523602e-04  1.594277e-04  1.668141e-04
## ASV4401     -9.642961e-05 -1.013114e-04 -1.064459e-04 -1.118462e-04
## ASV2891     -3.177653e-04 -3.325539e-04 -3.480146e-04 -3.641765e-04
## ASV2778     -7.149550e-05 -7.480565e-05 -7.826465e-05 -8.187877e-05
## ASV8744      1.398811e-04  1.460304e-04  1.524277e-04  1.590811e-04
## ASV1079      2.874283e-04  3.002592e-04  3.136250e-04  3.275447e-04
## ASV19688     2.178301e-05  2.297280e-05  2.423272e-05  2.556726e-05
## ASV4039      3.582584e-05  3.770157e-05  3.968168e-05  4.177239e-05
## ASV4982     -2.157723e-04 -2.256561e-04 -2.359746e-04 -2.467453e-04
## ASV1071     -2.157548e-04 -2.256369e-04 -2.359536e-04 -2.467223e-04
## ASV7666     -2.157372e-04 -2.256176e-04 -2.359325e-04 -2.466993e-04
## ASV0502      3.019311e-04  3.158710e-04  3.304337e-04  3.456453e-04
## ASV3624     -2.160703e-04 -2.259783e-04 -2.363228e-04 -2.471212e-04
## ASV0403      3.068610e-05  3.197457e-05  3.330925e-05  3.469108e-05
## ASV4939     -2.160507e-04 -2.259569e-04 -2.362994e-04 -2.470956e-04
## ASV6297     -2.588969e-04 -2.708952e-04 -2.834335e-04 -2.965349e-04
## ASV6343      2.302429e-04  2.402804e-04  2.507142e-04  2.615566e-04
## ASV0954     -4.847472e-05 -5.044429e-05 -5.247674e-05 -5.457233e-05
## ASV10225    -9.430660e-05 -9.876981e-05 -1.034410e-04 -1.083294e-04
## ASV1584      3.756906e-04  3.929221e-04  4.109129e-04  4.296937e-04
## ASV1803      1.377818e-04  1.438500e-04  1.501619e-04  1.567250e-04
## ASV2576     -3.756515e-04 -3.928793e-04 -4.108661e-04 -4.296426e-04
## ASV3252      2.443991e-04  2.557028e-04  2.675131e-04  2.798513e-04
## ASV3463     -3.756192e-04 -3.928440e-04 -4.108276e-04 -4.296005e-04
## ASV3822     -2.857919e-04 -2.991185e-04 -3.130534e-04 -3.276233e-04
## ASV4926     -1.515374e-04 -1.581284e-04 -1.649769e-04 -1.720904e-04
## ASV5564     -9.709935e-05 -1.015583e-04 -1.062146e-04 -1.110762e-04
## ASV5595     -5.666227e-05 -5.924936e-05 -6.194970e-05 -6.476783e-05
## ASV16463    -2.189692e-04 -2.291535e-04 -2.398001e-04 -2.509291e-04
## ASV6277      2.188908e-04  2.291974e-04  2.399823e-04  2.512669e-04
## ASV1344      2.189607e-04  2.291442e-04  2.397899e-04  2.509180e-04
## ASV1869      1.394956e-04  1.456687e-04  1.520927e-04  1.587755e-04
## ASV8155     -1.195669e-04 -1.248181e-04 -1.302792e-04 -1.359569e-04
## ASV2502     -2.210039e-04 -2.310957e-04 -2.416280e-04 -2.526182e-04
## ASV6742     -6.879921e-05 -7.172707e-05 -7.476337e-05 -7.791065e-05
## ASV3124     -1.435177e-04 -1.500612e-04 -1.568912e-04 -1.640192e-04
## ASV17042    -2.513536e-04 -2.628699e-04 -2.748925e-04 -2.874417e-04
## ASV0248      3.483838e-04  3.641986e-04  3.806961e-04  3.979025e-04
## ASV4557      5.953031e-05  6.262109e-05  6.587929e-05  6.931425e-05
## ASV3507     -3.822717e-04 -4.000041e-04 -4.185366e-04 -4.379032e-04
## ASV1870      2.808131e-05  2.937694e-05  3.073034e-05  3.214389e-05
## ASV2447     -1.842663e-04 -1.929097e-04 -2.019529e-04 -2.114137e-04
## ASV0347      2.991280e-04  3.130902e-04  3.276910e-04  3.429583e-04
## ASV1855     -1.372192e-04 -1.435831e-04 -1.502342e-04 -1.571848e-04
## ASV0568      1.030752e-04  1.077701e-04  1.126691e-04  1.177803e-04
## ASV1620     -1.836777e-04 -1.921530e-04 -2.010064e-04 -2.102534e-04
## ASV0101     -1.481351e-04 -1.545167e-04 -1.611427e-04 -1.680197e-04
## ASV7751      1.385375e-04  1.452494e-04  1.522907e-04  1.596780e-04
## ASV9033     -2.513462e-04 -2.630270e-04 -2.752370e-04 -2.879990e-04
## ASV3438     -7.293228e-05 -7.637146e-05 -7.997130e-05 -8.373916e-05
## ASV0637     -2.346366e-04 -2.454558e-04 -2.567569e-04 -2.685601e-04
## ASV1181     -1.734726e-04 -1.815435e-04 -1.899806e-04 -1.987995e-04
## ASV13480    -2.184439e-04 -2.285738e-04 -2.391604e-04 -2.502230e-04
## ASV14220    -2.184259e-04 -2.285541e-04 -2.391388e-04 -2.501993e-04
## ASV1448     -1.596051e-04 -1.670529e-04 -1.748409e-04 -1.829839e-04
## ASV1457      1.467128e-04  1.532518e-04  1.600611e-04  1.671501e-04
## ASV1645      1.059462e-04  1.109487e-04  1.161849e-04  1.216653e-04
## ASV2300     -1.421231e-04 -1.485822e-04 -1.553200e-04 -1.623473e-04
## ASV2533      2.187140e-04  2.286281e-04  2.389679e-04  2.497497e-04
## ASV5059      5.367872e-05  5.592586e-05  5.825259e-05  6.066041e-05
## ASV8871     -2.184187e-04 -2.285461e-04 -2.391299e-04 -2.501896e-04
## ASV1289     -2.337633e-04 -2.444141e-04 -2.555280e-04 -2.671230e-04
## ASV3983     -9.975073e-05 -1.044539e-04 -1.093762e-04 -1.145275e-04
## ASV10323    -7.924720e-05 -8.313017e-05 -8.720716e-05 -9.148806e-05
## ASV13279    -2.183726e-04 -2.284957e-04 -2.390747e-04 -2.501291e-04
## ASV7149     -2.183546e-04 -2.284760e-04 -2.390532e-04 -2.501055e-04
## ASV1691      4.167195e-05  4.365288e-05  4.572818e-05  4.790238e-05
## ASV1649      1.073824e-04  1.124102e-04  1.176679e-04  1.231653e-04
## ASV10120     3.161457e-05  3.314430e-05  3.474903e-05  3.643253e-05
## ASV8285     -2.787051e-04 -2.918473e-04 -3.056009e-04 -3.199934e-04
## ASV0037     -2.395787e-04 -2.507989e-04 -2.625353e-04 -2.748107e-04
## ASV1770      6.256696e-05  6.545615e-05  6.847492e-05  7.162875e-05
## ASV2252      5.985308e-05  6.261042e-05  6.549011e-05  6.849713e-05
## ASV7580      2.416702e-04  2.525012e-04  2.637865e-04  2.755422e-04
## ASV5643     -2.209828e-04 -2.311989e-04 -2.418730e-04 -2.530243e-04
## ASV2722     -7.112626e-05 -7.460357e-05 -7.825459e-05 -8.208828e-05
## ASV2662     -1.516499e-04 -1.587074e-04 -1.660861e-04 -1.738002e-04
## ASV0479     -3.457647e-04 -3.614911e-04 -3.778991e-04 -3.950151e-04
## ASV2009     -3.638335e-04 -3.801542e-04 -3.971603e-04 -4.148764e-04
## ASV3731     -2.452561e-04 -2.563612e-04 -2.679424e-04 -2.800177e-04
## ASV5497     -3.035320e-04 -3.174331e-04 -3.319452e-04 -3.470930e-04
## ASV6647      1.332071e-05  1.380352e-05  1.429522e-05  1.479493e-05
## ASV8974     -2.236851e-04 -2.338757e-04 -2.445088e-04 -2.556018e-04
## ASV15527     1.954098e-05  2.037728e-05  2.124509e-05  2.214522e-05
## ASV6705     -1.382285e-04 -1.450432e-04 -1.522025e-04 -1.597245e-04
## ASV0354      2.861897e-04  2.994157e-04  3.132340e-04  3.276693e-04
## ASV2707      6.527255e-05  6.808551e-05  7.100577e-05  7.403613e-05
## ASV11167    -3.759879e-04 -3.932548e-04 -4.112843e-04 -4.301072e-04
## ASV6393     -2.992156e-04 -3.130052e-04 -3.274086e-04 -3.424510e-04
## ASV3808     -2.132275e-04 -2.228192e-04 -2.328175e-04 -2.432375e-04
## ASV9337      2.943479e-05  3.060893e-05  3.181798e-05  3.306174e-05
## ASV5043     -3.069538e-04 -3.210917e-04 -3.358581e-04 -3.512788e-04
## ASV4189     -8.786702e-06 -9.030161e-06 -9.269400e-06 -9.502847e-06
## ASV1304     -1.165595e-04 -1.215124e-04 -1.266487e-04 -1.319728e-04
## ASV2105     -1.608876e-04 -1.683207e-04 -1.760867e-04 -1.841995e-04
## ASV2421     -5.601614e-05 -5.866703e-05 -6.144284e-05 -6.434943e-05
## ASV3170      2.572533e-04  2.692622e-04  2.818203e-04  2.949517e-04
## ASV5036      3.444923e-04  3.603282e-04  3.768655e-04  3.941328e-04
## ASV2286      2.173529e-04  2.273844e-04  2.378641e-04  2.488107e-04
## ASV3363      2.175398e-04  2.277976e-04  2.385337e-04  2.497700e-04
## ASV5759     -2.007216e-05 -2.108032e-05 -2.214154e-05 -2.325881e-05
## ASV5440     -1.507293e-04 -1.579466e-04 -1.655101e-04 -1.734363e-04
## ASV2050      2.495358e-04  2.605865e-04  2.720865e-04  2.840505e-04
## ASV4478      1.781872e-04  1.866269e-04  1.954636e-04  2.047155e-04
## ASV5725     -1.917497e-04 -2.004565e-04 -2.095393e-04 -2.190126e-04
## ASV1600     -5.570025e-05 -5.871135e-05 -6.189650e-05 -6.526636e-05
## ASV1654     -3.414023e-04 -3.569365e-04 -3.731445e-04 -3.900526e-04
## ASV3781     -1.472239e-04 -1.538127e-04 -1.606767e-04 -1.678255e-04
## ASV7144     -1.264204e-04 -1.320465e-04 -1.379043e-04 -1.440017e-04
## ASV12710    -4.639870e-05 -4.823623e-05 -5.012793e-05 -5.207354e-05
## ASV3317      1.721806e-04  1.800815e-04  1.883319e-04  1.969464e-04
## ASV3249     -3.372290e-04 -3.527164e-04 -3.688879e-04 -3.857713e-04
## ASV0669     -2.101025e-04 -2.194774e-04 -2.292418e-04 -2.394094e-04
## ASV0893      1.243298e-04  1.299900e-04  1.358958e-04  1.420568e-04
## ASV11060    -1.243197e-04 -1.299790e-04 -1.358838e-04 -1.420436e-04
## ASV3207      4.292463e-04  4.494193e-04  4.705266e-04  4.926100e-04
## ASV3498     -1.243184e-04 -1.299776e-04 -1.358823e-04 -1.420420e-04
## ASV4358      7.882095e-05  8.243304e-05  8.620394e-05  9.014001e-05
## ASV4806      2.135136e-04  2.233145e-04  2.335477e-04  2.442305e-04
## ASV4941      1.243129e-04  1.299716e-04  1.358757e-04  1.420348e-04
## ASV6998      3.726053e-05  3.896852e-05  4.075139e-05  4.261209e-05
## ASV7327     -1.243051e-04 -1.299631e-04 -1.358665e-04 -1.420247e-04
## ASV5112      2.515255e-04  2.632436e-04  2.754942e-04  2.883003e-04
## ASV5345     -1.242867e-04 -1.299429e-04 -1.358443e-04 -1.420005e-04
## ASV8911     -1.242766e-04 -1.299319e-04 -1.358323e-04 -1.419873e-04
## ASV5061      2.904980e-04  3.038211e-04  3.177309e-04  3.322511e-04
## ASV1968     -2.567790e-05 -2.698857e-05 -2.836943e-05 -2.982447e-05
## ASV4669     -1.242579e-04 -1.299115e-04 -1.358100e-04 -1.419630e-04
## ASV6209     -4.589020e-05 -4.783750e-05 -4.985580e-05 -5.194658e-05
## ASV6938      2.469355e-04  2.581106e-04  2.697638e-04  2.819132e-04
## ASV6987      1.370505e-04  1.430816e-04  1.493550e-04  1.558783e-04
## ASV7842     -1.242529e-04 -1.299061e-04 -1.358041e-04 -1.419566e-04
## ASV17950     8.153309e-08  8.813670e-08  9.520396e-08  1.027570e-07
## ASV3380     -3.618455e-04 -3.781804e-04 -3.952112e-04 -4.129641e-04
## ASV13740    -3.088607e-04 -3.231985e-04 -3.381844e-04 -3.538461e-04
## ASV4313     -1.811592e-04 -1.895350e-04 -1.982859e-04 -2.074277e-04
## ASV3891     -1.876085e-04 -1.957096e-04 -2.041231e-04 -2.128576e-04
## ASV3322     -2.191970e-04 -2.292979e-04 -2.398488e-04 -2.508683e-04
## ASV1668     -3.787285e-05 -3.970659e-05 -4.163114e-05 -4.365124e-05
## ASV1739      8.454008e-05  8.823408e-05  9.207405e-05  9.606436e-05
## ASV3194      1.746149e-04  1.826225e-04  1.909831e-04  1.997109e-04
## ASV0071     -2.621748e-04 -2.735579e-04 -2.853855e-04 -2.976706e-04
## ASV0695      1.268568e-04  1.328130e-04  1.390425e-04  1.455569e-04
## ASV3835     -9.901417e-05 -1.034588e-04 -1.080905e-04 -1.129158e-04
## ASV1876      1.025190e-04  1.073249e-04  1.123518e-04  1.176096e-04
## ASV4892     -3.041991e-04 -3.182626e-04 -3.329562e-04 -3.483066e-04
## ASV1212     -1.047508e-04 -1.095465e-04 -1.145532e-04 -1.197795e-04
## ASV2640      1.371752e-06  1.378158e-06  1.379685e-06  1.375668e-06
## ASV7236     -3.008216e-04 -3.148031e-04 -3.294182e-04 -3.446940e-04
## ASV2353     -8.430709e-05 -8.834323e-05 -9.257319e-05 -9.700631e-05
## ASV0276      3.650089e-04  3.812272e-04  3.981145e-04  4.156941e-04
## ASV2262     -1.114148e-04 -1.165343e-04 -1.218813e-04 -1.274654e-04
## ASV11201    -7.476945e-05 -7.833220e-05 -8.206425e-05 -8.597357e-05
## ASV0665      3.001667e-05  3.135114e-05  3.274116e-05  3.418876e-05
## ASV5238      2.968563e-05  3.054292e-05  3.139204e-05  3.222855e-05
## ASV6885     -1.650379e-04 -1.725776e-04 -1.804471e-04 -1.886594e-04
## ASV1844      6.749533e-05  7.089927e-05  7.448154e-05  7.825188e-05
## ASV0379      2.152622e-04  2.250949e-04  2.353572e-04  2.460660e-04
## ASV1040     -6.716210e-05 -7.009331e-05 -7.314028e-05 -7.630650e-05
## ASV7913     -1.249481e-04 -1.306950e-04 -1.366964e-04 -1.429628e-04
## ASV1197     -2.152307e-04 -2.250605e-04 -2.353195e-04 -2.460249e-04
## ASV5918      9.332830e-05  9.765524e-05  1.021774e-04  1.069030e-04
## ASV8045      4.856595e-05  5.099307e-05  5.354502e-05  5.622839e-05
## ASV16458    -2.134418e-05 -2.216342e-05 -2.300386e-05 -2.386497e-05
## ASV10827    -2.152181e-04 -2.250468e-04 -2.353046e-04 -2.460087e-04
## ASV3658     -2.152006e-04 -2.250277e-04 -2.352837e-04 -2.459858e-04
## ASV0073     -4.468692e-04 -4.676017e-04 -4.892693e-04 -5.119115e-04
## ASV1951     -9.086056e-05 -9.543210e-05 -1.002416e-04 -1.053017e-04
## ASV7630     -2.840503e-04 -2.970869e-04 -3.106988e-04 -3.249093e-04
## ASV9449     -1.518777e-04 -1.590650e-04 -1.665890e-04 -1.744651e-04
## ASV3944      3.048916e-04  3.188404e-04  3.334016e-04  3.485999e-04
## ASV1520     -4.122983e-04 -4.310644e-04 -4.506440e-04 -4.710686e-04
## ASV0307      3.192887e-04  3.341819e-04  3.497548e-04  3.660371e-04
## ASV12731    -8.116024e-05 -8.504563e-05 -8.911784e-05 -9.338591e-05
## ASV0282      3.205679e-04  3.355201e-04  3.511548e-04  3.675016e-04
## ASV2646      2.864596e-04  2.991859e-04  3.124354e-04  3.262256e-04
## ASV3536      2.283468e-04  2.388642e-04  2.498491e-04  2.613206e-04
## ASV10089    -2.096780e-04 -2.189930e-04 -2.286910e-04 -2.387850e-04
## ASV1185      2.096614e-04  2.189749e-04  2.286713e-04  2.387635e-04
## ASV1452      2.096448e-04  2.189569e-04  2.286516e-04  2.387421e-04
## ASV1700      2.096282e-04  2.189388e-04  2.286319e-04  2.387206e-04
## ASV6948     -2.096117e-04 -2.189207e-04 -2.286122e-04 -2.386991e-04
## ASV0389     -2.737253e-04 -2.859661e-04 -2.987175e-04 -3.119974e-04
## ASV11884     2.933775e-06  3.374165e-06  3.861198e-06  4.399101e-06
## ASV23165    -2.095755e-04 -2.188813e-04 -2.285692e-04 -2.386523e-04
## ASV2841      2.095589e-04  2.188632e-04  2.285496e-04  2.386309e-04
## ASV2949      2.095423e-04  2.188452e-04  2.285299e-04  2.386094e-04
## ASV4037      2.095258e-04  2.188271e-04  2.285102e-04  2.385879e-04
## ASV4477      2.095092e-04  2.188090e-04  2.284905e-04  2.385665e-04
## ASV4496      2.094927e-04  2.187910e-04  2.284708e-04  2.385450e-04
## ASV5784     -2.094761e-04 -2.187729e-04 -2.284511e-04 -2.385236e-04
## ASV6035      5.614743e-06  6.070210e-06  6.563608e-06  7.098034e-06
## ASV6232     -2.098352e-04 -2.191478e-04 -2.288424e-04 -2.389320e-04
## ASV1818      2.094436e-04  2.187375e-04  2.284126e-04  2.384816e-04
## ASV2595      2.094271e-04  2.187195e-04  2.283929e-04  2.384602e-04
## ASV2788     -2.751845e-05 -2.875480e-05 -3.004309e-05 -3.138515e-05
## ASV5018      2.094120e-04  2.187030e-04  2.283749e-04  2.384406e-04
## ASV0127      2.847183e-04  2.979789e-04  3.118428e-04  3.263363e-04
## ASV1527      6.785642e-06  7.183961e-06  7.607542e-06  8.058062e-06
## ASV1055      1.613784e-04  1.687767e-04  1.765004e-04  1.845626e-04
## ASV4791      1.029554e-04  1.070290e-04  1.112234e-04  1.155384e-04
## ASV0859      1.152164e-04  1.204082e-04  1.258195e-04  1.314583e-04
## ASV12971    -3.077462e-04 -3.219318e-04 -3.367488e-04 -3.522231e-04
## ASV16856    -3.077210e-04 -3.219042e-04 -3.367186e-04 -3.521900e-04
## ASV7321     -2.514318e-04 -2.630403e-04 -2.751672e-04 -2.878339e-04
## ASV8780     -3.076756e-04 -3.218546e-04 -3.366642e-04 -3.521306e-04
## ASV1569      2.253539e-04  2.356835e-04  2.464678e-04  2.577252e-04
## ASV3696      3.620413e-05  3.779187e-05  3.944261e-05  4.115823e-05
## ASV0624      4.122908e-04  4.311375e-04  4.508108e-04  4.713437e-04
## ASV0495      2.511391e-04  2.624632e-04  2.742684e-04  2.865723e-04
## ASV16971    -1.256833e-04 -1.314698e-04 -1.375133e-04 -1.438244e-04
## ASV6535      7.186608e-05  7.535739e-05  7.902077e-05  8.286486e-05
## ASV1897      2.947739e-04  3.081077e-04  3.220124e-04  3.365095e-04
## ASV2631     -3.849426e-05 -4.051694e-05 -4.265276e-05 -4.490853e-05
## ASV6204      9.919791e-05  1.038343e-04  1.086827e-04  1.137523e-04
## ASV3312     -1.896987e-04 -1.984751e-04 -2.076459e-04 -2.172278e-04
## ASV3360      1.203480e-04  1.260421e-04  1.320030e-04  1.382430e-04
## ASV3907      5.851653e-05  6.131621e-05  6.424979e-05  6.732361e-05
## ASV6090      6.008524e-05  6.287418e-05  6.578855e-05  6.883358e-05
## ASV8652     -6.894675e-05 -7.198216e-05 -7.513975e-05 -7.842338e-05
## ASV11129    -1.242785e-04 -1.299375e-04 -1.358424e-04 -1.420029e-04
## ASV11073    -1.242684e-04 -1.299264e-04 -1.358303e-04 -1.419897e-04
## ASV1840      4.158979e-04  4.347768e-04  4.544691e-04  4.750057e-04
## ASV2298      1.568312e-04  1.638715e-04  1.712086e-04  1.788533e-04
## ASV2420      3.730912e-04  3.903062e-04  4.082898e-04  4.270738e-04
## ASV6474      5.116589e-05  5.361374e-05  5.617830e-05  5.886502e-05
## ASV8475     -1.242550e-04 -1.299118e-04 -1.358144e-04 -1.419723e-04
## ASV8679     -1.242449e-04 -1.299008e-04 -1.358023e-04 -1.419591e-04
## ASV6527      1.186768e-04  1.242344e-04  1.300478e-04  1.361283e-04
## ASV2504     -2.004183e-05 -2.112087e-05 -2.226215e-05 -2.346949e-05
## ASV1093     -1.320069e-04 -1.380632e-04 -1.443863e-04 -1.509867e-04
## ASV0994      1.739048e-04  1.819204e-04  1.902929e-04  1.990372e-04
## ASV0092     -2.872395e-04 -3.007009e-04 -3.147822e-04 -3.295111e-04
## ASV2619      6.523701e-05  6.830239e-05  7.150947e-05  7.486454e-05
## ASV0121      3.615989e-04  3.775606e-04  3.941689e-04  4.114451e-04
## ASV0932      1.251544e-04  1.311079e-04  1.373428e-04  1.438723e-04
## ASV5229      2.080995e-04  2.175015e-04  2.273043e-04  2.375228e-04
## ASV6737      2.125968e-04  2.224304e-04  2.327048e-04  2.434386e-04
## ASV11213    -2.989830e-04 -3.123540e-04 -3.262828e-04 -3.407889e-04
## ASV1151      6.181024e-04  6.464590e-04  6.760659e-04  7.069736e-04
## ASV3813      3.222481e-04  3.367438e-04  3.518518e-04  3.675944e-04
## ASV5566      6.776522e-05  7.130057e-05  7.503131e-05  7.896893e-05
## ASV7529     -2.989467e-04 -3.123145e-04 -3.262398e-04 -3.407420e-04
## ASV2193      4.329164e-04  4.530816e-04  4.741644e-04  4.962045e-04
## ASV2349      3.976812e-04  4.160362e-04  4.352116e-04  4.552417e-04
## ASV2387      3.479992e-04  3.635098e-04  3.796624e-04  3.964792e-04
## ASV2699      2.912608e-04  3.049939e-04  3.193675e-04  3.344109e-04
## ASV3353      3.787601e-04  3.960201e-04  4.140301e-04  4.328193e-04
## ASV3621      2.012193e-04  2.101630e-04  2.194745e-04  2.291665e-04
## ASV3848      3.598797e-05  3.771536e-05  3.952605e-05  4.142407e-05
## ASV4440      5.309432e-06  5.825202e-06  6.388698e-06  7.004097e-06
## ASV4751      3.998081e-04  4.182603e-04  4.375366e-04  4.576714e-04
## ASV5115      1.715569e-04  1.795802e-04  1.879711e-04  1.967455e-04
## ASV5850     -2.988837e-04 -3.122457e-04 -3.261647e-04 -3.406602e-04
## ASV6293      1.854308e-04  1.939711e-04  2.028910e-04  2.122060e-04
## ASV6513      8.222879e-05  8.629018e-05  9.055756e-05  9.504175e-05
## ASV7628     -2.988642e-04 -3.122245e-04 -3.261415e-04 -3.406349e-04
## ASV7658      1.835404e-04  1.921399e-04  2.011342e-04  2.105405e-04
## ASV0776     -3.519231e-04 -3.677811e-04 -3.843113e-04 -4.015383e-04
## ASV10227    -2.988429e-04 -3.122013e-04 -3.261162e-04 -3.406073e-04
## ASV11965    -2.988191e-04 -3.121753e-04 -3.260879e-04 -3.405765e-04
## ASV1270     -1.008446e-04 -1.052270e-04 -1.097800e-04 -1.145085e-04
## ASV13123    -2.254640e-04 -2.354669e-04 -2.458797e-04 -2.567159e-04
## ASV5828      2.987725e-04  3.121244e-04  3.260324e-04  3.405160e-04
## ASV5920     -2.987487e-04 -3.120985e-04 -3.260041e-04 -3.404852e-04
## ASV6071      2.851447e-04  2.984108e-04  3.122796e-04  3.267769e-04
## ASV6723     -1.384333e-05 -1.429574e-05 -1.475151e-05 -1.520933e-05
## ASV6727     -2.987188e-04 -3.120659e-04 -3.259686e-04 -3.404463e-04
## ASV7759     -2.986950e-04 -3.120399e-04 -3.259403e-04 -3.404155e-04
## ASV0733      2.123990e-05  2.227260e-05  2.335686e-05  2.449540e-05
## ASV1655     -4.598186e-05 -4.835757e-05 -5.086281e-05 -5.350511e-05
## ASV0755     -4.451319e-04 -4.652449e-04 -4.862168e-04 -5.080797e-04
## ASV0796      1.803373e-04  1.880951e-04  1.961484e-04  2.045049e-04
## ASV0878      3.865071e-04  4.042192e-04  4.227105e-04  4.420121e-04
## ASV4988     -2.399690e-04 -2.509828e-04 -2.624825e-04 -2.744877e-04
## ASV0083     -2.744089e-04 -2.872067e-04 -3.005868e-04 -3.145742e-04
## ASV0273      1.280534e-04  1.335468e-04  1.392494e-04  1.451668e-04
## ASV3076      9.036367e-05  9.461187e-05  9.905692e-05  1.037077e-04
## ASV1513      7.387459e-05  7.722389e-05  8.071703e-05  8.435945e-05
## ASV5159     -1.836242e-05 -1.907276e-05 -1.980256e-05 -2.055160e-05
## ASV3422     -1.828211e-04 -1.913135e-04 -2.001904e-04 -2.094683e-04
## ASV12230    -2.582776e-05 -2.690591e-05 -2.802172e-05 -2.917580e-05
## ASV1694      3.768618e-04  3.938219e-04  4.115013e-04  4.299266e-04
## ASV1249      1.656124e-04  1.732499e-04  1.812275e-04  1.895593e-04
## ASV1697     -9.126324e-05 -9.537258e-05 -9.965610e-05 -1.041202e-04
## ASV4408     -2.226537e-04 -2.322429e-04 -2.422004e-04 -2.525366e-04
## ASV0095     -2.833836e-04 -2.967353e-04 -3.107085e-04 -3.253313e-04
## ASV0410      5.632164e-07  4.172285e-07  2.485695e-07  5.478846e-08
## ASV4642     -3.534144e-04 -3.697340e-04 -3.867830e-04 -4.045917e-04
## ASV4560     -1.008669e-06 -8.684571e-07 -7.046617e-07 -5.147125e-07
## ASV7586     -1.665856e-04 -1.743171e-04 -1.823976e-04 -1.908418e-04
## ASV4144     -1.875932e-04 -1.963619e-04 -2.055322e-04 -2.151218e-04
## ASV0327     -2.028227e-04 -2.120737e-04 -2.217275e-04 -2.318002e-04
## ASV0946     -1.702201e-04 -1.776241e-04 -1.853191e-04 -1.933139e-04
## ASV3254     -2.197206e-04 -2.299699e-04 -2.406868e-04 -2.518916e-04
## ASV0349      3.169863e-04  3.316492e-04  3.469695e-04  3.629748e-04
## ASV0472     -1.929583e-04 -2.017643e-04 -2.109540e-04 -2.205427e-04
## ASV1330      1.936226e-04  2.021771e-04  2.110785e-04  2.203379e-04
## ASV2605      2.064976e-04  2.160515e-04  2.260338e-04  2.364624e-04
## ASV2846     -1.183764e-04 -1.240363e-04 -1.299666e-04 -1.361804e-04
## ASV3982     -9.625340e-05 -1.007971e-04 -1.055531e-04 -1.105312e-04
## ASV4116     -2.196885e-04 -2.299347e-04 -2.406482e-04 -2.518493e-04
## ASV6048     -1.287070e-04 -1.347423e-04 -1.410557e-04 -1.476598e-04
## ASV1146      2.647260e-04  2.768683e-04  2.895453e-04  3.027784e-04
## ASV13362     1.527905e-05  1.589074e-05  1.652108e-05  1.717004e-05
## ASV1422     -2.196647e-04 -2.299086e-04 -2.406196e-04 -2.518179e-04
## ASV3640     -2.196465e-04 -2.298887e-04 -2.405977e-04 -2.517939e-04
## ASV5404      1.712517e-04  1.788493e-04  1.867586e-04  1.949903e-04
## ASV6118     -2.196343e-04 -2.298752e-04 -2.405830e-04 -2.517777e-04
## ASV1115     -1.874809e-04 -1.962255e-04 -2.053684e-04 -2.149269e-04
## ASV0888     -4.008622e-04 -4.193104e-04 -4.385776e-04 -4.586973e-04
## ASV4620      5.094057e-05  5.261312e-05  5.429988e-05  5.599625e-05
## ASV3099      7.919073e-05  8.300829e-05  8.701118e-05  9.120843e-05
## ASV7099      3.682481e-05  3.861385e-05  4.049092e-05  4.246040e-05
## ASV5892     -2.524320e-04 -2.640774e-04 -2.762422e-04 -2.889480e-04
## ASV6978     -2.515890e-04 -2.633136e-04 -2.755725e-04 -2.883889e-04
## ASV6555     -8.631179e-05 -9.076407e-05 -9.545797e-05 -1.004074e-04
## ASV0539     -3.164880e-04 -3.309016e-04 -3.459410e-04 -3.616306e-04
## ASV4665      8.822985e-05  9.199869e-05  9.590831e-05  9.996215e-05
## ASV2210      1.897358e-04  1.979550e-04  2.064959e-04  2.153683e-04
## ASV1329      2.004952e-04  2.098538e-04  2.196395e-04  2.298707e-04
## ASV7123     -2.909402e-04 -3.044870e-04 -3.186503e-04 -3.334567e-04
## ASV1260      1.975609e-06  2.108432e-06  2.250976e-06  2.403980e-06
## ASV1011      2.974450e-04  3.115183e-04  3.262516e-04  3.416752e-04
## ASV4233      8.133426e-05  8.517344e-05  8.919194e-05  9.339793e-05
## ASV1475      3.014639e-04  3.151963e-04  3.295268e-04  3.444791e-04
## ASV6099     -3.490897e-04 -3.649989e-04 -3.815997e-04 -3.989194e-04
## ASV1428      3.082865e-06  3.980597e-06  4.987127e-06  6.113078e-06
## ASV5101     -3.837903e-04 -4.017940e-04 -4.206295e-04 -4.403339e-04
## ASV11827    -1.729008e-04 -1.808978e-04 -1.892534e-04 -1.979828e-04
## ASV13899    -1.965929e-04 -2.056793e-04 -2.151726e-04 -2.250898e-04
## ASV21259    -2.309240e-04 -2.416531e-04 -2.528681e-04 -2.645898e-04
## ASV6635     -1.143411e-04 -1.197620e-04 -1.254385e-04 -1.313824e-04
## ASV9922     -3.094769e-04 -3.238296e-04 -3.388297e-04 -3.545047e-04
## ASV2869      3.795056e-05  3.964455e-05  4.140849e-05  4.324472e-05
## ASV1740      2.017572e-04  2.109387e-04  2.205182e-04  2.305109e-04
## ASV4406     -3.120653e-04 -3.266656e-04 -3.419367e-04 -3.579082e-04
## ASV5586     -2.662782e-04 -2.788308e-04 -2.919688e-04 -3.057187e-04
## ASV3255     -1.054147e-04 -1.102409e-04 -1.152791e-04 -1.205378e-04
## ASV12281    -1.477345e-04 -1.543880e-04 -1.613240e-04 -1.685532e-04
## ASV5388     -2.910013e-04 -3.039888e-04 -3.175155e-04 -3.316002e-04
## ASV17660    -2.996603e-04 -3.135149e-04 -3.279906e-04 -3.431136e-04
## ASV0159      1.644496e-04  1.717314e-04  1.793132e-04  1.872058e-04
## ASV2734     -4.440054e-04 -4.643518e-04 -4.855935e-04 -5.077665e-04
## ASV2049      3.380387e-05  3.537221e-05  3.701166e-05  3.872533e-05
## ASV2465      2.095579e-05  2.159344e-05  2.223031e-05  2.286386e-05
## ASV2147      1.371226e-04  1.428576e-04  1.487962e-04  1.549423e-04
## ASV3113     -4.274168e-05 -4.466677e-05 -4.667283e-05 -4.876270e-05
## ASV0622     -3.150939e-04 -3.297247e-04 -3.450162e-04 -3.609964e-04
## ASV0437     -3.156412e-04 -3.301157e-04 -3.452278e-04 -3.610030e-04
## ASV6385     -3.454444e-04 -3.614439e-04 -3.781629e-04 -3.956318e-04
## ASV3699     -3.137975e-04 -3.285607e-04 -3.440096e-04 -3.601754e-04
## ASV2208      3.137713e-04  3.285319e-04  3.439781e-04  3.601409e-04
## ASV1053      7.156961e-05  7.485428e-05  7.828433e-05  8.186572e-05
## ASV8468     -6.998984e-05 -7.313288e-05 -7.640822e-05 -7.982063e-05
## ASV0951     -2.626844e-04 -2.746711e-04 -2.871807e-04 -3.002338e-04
## ASV0278      3.752796e-04  3.921677e-04  4.097703e-04  4.281137e-04
## ASV0914     -1.965518e-04 -2.055547e-04 -2.149529e-04 -2.247622e-04
## ASV0737      2.926272e-04  3.054243e-04  3.187296e-04  3.325588e-04
## ASV2038      4.235467e-04  4.426898e-04  4.626507e-04  4.834603e-04
## ASV2171      2.567268e-04  2.678737e-04  2.794558e-04  2.914856e-04
## ASV2607      2.925739e-04  3.053662e-04  3.186664e-04  3.324899e-04
## ASV3143      2.219357e-04  2.314944e-04  2.414190e-04  2.517194e-04
## ASV3187     -3.139546e-04 -3.277190e-04 -3.420334e-04 -3.569150e-04
## ASV3810      2.925105e-04  3.052972e-04  3.185912e-04  3.324081e-04
## ASV5060     -1.798605e-04 -1.875798e-04 -1.955921e-04 -2.039051e-04
## ASV5325      2.924752e-04  3.052588e-04  3.185494e-04  3.323627e-04
## ASV6905     -2.924524e-04 -3.052340e-04 -3.185224e-04 -3.323333e-04
## ASV7597     -2.924297e-04 -3.052092e-04 -3.184955e-04 -3.323040e-04
## ASV9652     -2.924070e-04 -3.051845e-04 -3.184685e-04 -3.322747e-04
## ASV2634      2.923842e-04  3.051597e-04  3.184416e-04  3.322454e-04
## ASV3065      2.923615e-04  3.051350e-04  3.184147e-04  3.322161e-04
## ASV3331      2.923388e-04  3.051102e-04  3.183877e-04  3.321868e-04
## ASV7434     -2.923161e-04 -3.050855e-04 -3.183608e-04 -3.321575e-04
## ASV7720      4.767597e-05  5.033993e-05  5.316440e-05  5.615965e-05
## ASV8414     -2.922956e-04 -3.050633e-04 -3.183367e-04 -3.321313e-04
## ASV12139    -2.922729e-04 -3.050386e-04 -3.183098e-04 -3.321020e-04
## ASV1824      2.847946e-04  2.972164e-04  3.101285e-04  3.235458e-04
## ASV2094      2.885679e-04  3.011670e-04  3.142647e-04  3.278762e-04
## ASV2770     -6.705610e-05 -7.046713e-05 -7.405846e-05 -7.783995e-05
## ASV3505     -1.406079e-04 -1.463552e-04 -1.522925e-04 -1.584219e-04
## ASV1935      2.921994e-04  3.049587e-04  3.182229e-04  3.320076e-04
## ASV5764     -2.921767e-04 -3.049340e-04 -3.181960e-04 -3.319784e-04
## ASV6806      1.872637e-04  1.961068e-04  2.053630e-04  2.150508e-04
## ASV6942     -2.921557e-04 -3.049110e-04 -3.181711e-04 -3.319512e-04
## ASV1166      3.211811e-04  3.352833e-04  3.499509e-04  3.652019e-04
## ASV1664      2.285158e-04  2.387385e-04  2.493878e-04  2.604785e-04
## ASV2568      2.921118e-04  3.048633e-04  3.181191e-04  3.318947e-04
## ASV3525      2.920892e-04  3.048386e-04  3.180922e-04  3.318654e-04
## ASV4965     -3.499571e-04 -3.656108e-04 -3.819186e-04 -3.989039e-04
## ASV6607     -1.803621e-04 -1.879287e-04 -1.957655e-04 -2.038778e-04
## ASV7187      9.918722e-05  1.036764e-04  1.083574e-04  1.132371e-04
## ASV0388     -2.903483e-04 -3.040889e-04 -3.184748e-04 -3.335358e-04
## ASV1420      2.019304e-06  2.205302e-06  2.407906e-06  2.628528e-06
## ASV14293     9.438104e-05  9.894808e-05  1.037385e-04  1.087634e-04
## ASV17785     2.011610e-06  2.196833e-06  2.398586e-06  2.618268e-06
## ASV7678      1.777269e-05  1.815887e-05  1.852330e-05  1.886167e-05
## ASV2253      7.962693e-05  8.347025e-05  8.750053e-05  9.172693e-05
## ASV4150      1.593754e-04  1.664413e-04  1.737971e-04  1.814524e-04
## ASV3836     -3.688273e-04 -3.857316e-04 -4.033803e-04 -4.218035e-04
## ASV16231    -3.027502e-04 -3.169073e-04 -3.317141e-04 -3.471993e-04
## ASV2730      6.105486e-06  6.390151e-06  6.688047e-06  6.999806e-06
## ASV2072      1.715401e-04  1.789876e-04  1.867259e-04  1.947635e-04
## ASV2160      4.612110e-05  4.847891e-05  5.096340e-05  5.358183e-05
## ASV5013      5.599727e-05  5.833181e-05  6.074712e-05  6.324434e-05
## ASV2586      1.007043e-04  1.052694e-04  1.100302e-04  1.149940e-04
## ASV1442      7.904493e-05  8.270551e-05  8.652932e-05  9.052291e-05
## ASV3101      1.122964e-04  1.170215e-04  1.219155e-04  1.269817e-04
## ASV3323     -9.403827e-05 -9.848568e-05 -1.031371e-04 -1.080011e-04
## ASV1812      2.880131e-04  3.005733e-04  3.136292e-04  3.271958e-04
## ASV6120     -3.418354e-05 -3.592291e-05 -3.775464e-05 -3.968386e-05
## ASV2565      6.284246e-05  6.557179e-05  6.840771e-05  7.135332e-05
## ASV6687      3.231742e-05  3.376505e-05  3.527326e-05  3.684419e-05
## ASV5357     -2.525414e-04 -2.641477e-04 -2.762673e-04 -2.889211e-04
## ASV9383      1.254366e-04  1.309998e-04  1.367913e-04  1.428188e-04
## ASV11753    -2.161338e-04 -2.260470e-04 -2.363971e-04 -2.472016e-04
## ASV11512    -5.993396e-05 -6.268011e-05 -6.554718e-05 -6.854006e-05
## ASV2791     -9.534625e-06 -1.008665e-05 -1.067357e-05 -1.129776e-05
## ASV0664     -4.570367e-04 -4.778829e-04 -4.996366e-04 -5.223334e-04
## ASV3436      4.732036e-05  4.978582e-05  5.238812e-05  5.513549e-05
## ASV5755      3.111866e-04  3.253110e-04  3.400438e-04  3.554083e-04
## ASV10970    -3.060811e-04 -3.201105e-04 -3.347568e-04 -3.500448e-04
## ASV11798    -1.561686e-04 -1.633203e-04 -1.707859e-04 -1.785781e-04
## ASV18193    -3.060452e-04 -3.200711e-04 -3.347138e-04 -3.499978e-04
## ASV2548      3.218342e-04  3.363435e-04  3.514700e-04  3.672366e-04
## ASV3901      3.478602e-04  3.635448e-04  3.798967e-04  3.969407e-04
## ASV5197      5.967454e-06  5.874549e-06  5.745555e-06  5.576355e-06
## ASV5859      1.544191e-04  1.613966e-04  1.686727e-04  1.762586e-04
## ASV6240     -3.060309e-04 -3.200554e-04 -3.346966e-04 -3.499789e-04
## ASV7281      3.060059e-04  3.200281e-04  3.346667e-04  3.499463e-04
## ASV7635      1.719610e-04  1.799285e-04  1.882541e-04  1.969531e-04
## ASV8822     -3.059858e-04 -3.200062e-04 -3.346427e-04 -3.499201e-04
## ASV4810     -6.492337e-05 -6.769708e-05 -7.057347e-05 -7.355480e-05
## ASV5308      3.201859e-04  3.348759e-04  3.502137e-04  3.662254e-04
## ASV2749     -3.506555e-04 -3.668497e-04 -3.837678e-04 -4.014399e-04
## ASV0298      2.699140e-05  2.862106e-05  3.035878e-05  3.221224e-05
## ASV2597     -3.287999e-04 -3.440299e-04 -3.599450e-04 -3.765739e-04
## ASV5758     -1.369156e-04 -1.432163e-04 -1.497971e-04 -1.566693e-04
## ASV9987     -3.474685e-04 -3.634782e-04 -3.802002e-04 -3.976638e-04
## ASV0971      7.008575e-05  7.295190e-05  7.591530e-05  7.897759e-05
## ASV0627     -3.392315e-04 -3.549729e-04 -3.714250e-04 -3.886180e-04
## ASV1758      3.072860e-04  3.213763e-04  3.360875e-04  3.514447e-04
## ASV4559      1.338287e-06  1.448447e-06  1.567542e-06  1.696243e-06
## ASV11400    -1.268730e-05 -1.313431e-05 -1.358811e-05 -1.404771e-05
## ASV11559    -3.090710e-04 -3.233868e-04 -3.383467e-04 -3.539780e-04
## ASV3943     -3.090455e-04 -3.233589e-04 -3.383161e-04 -3.539445e-04
## ASV10389     5.772135e-05  6.021129e-05  6.279605e-05  6.547803e-05
## ASV5168      2.730412e-04  2.852477e-04  2.979633e-04  3.112058e-04
## ASV5724      1.907715e-04  1.996233e-04  2.088743e-04  2.185415e-04
## ASV6337      5.987427e-05  6.236185e-05  6.493509e-05  6.759526e-05
## ASV11063     1.726222e-04  1.801821e-04  1.880430e-04  1.962144e-04
## ASV4279     -3.296388e-05 -3.447745e-05 -3.605780e-05 -3.770762e-05
## ASV7660     -1.281001e-04 -1.341144e-04 -1.404069e-04 -1.469900e-04
## ASV8218     -1.280894e-04 -1.341027e-04 -1.403941e-04 -1.469759e-04
## ASV3574      5.023989e-04  5.258629e-04  5.504006e-04  5.760589e-04
## ASV12050    -1.280914e-04 -1.341049e-04 -1.403965e-04 -1.469785e-04
## ASV3897      1.143365e-04  1.194219e-04  1.247172e-04  1.302297e-04
## ASV3856     -3.859403e-04 -4.036632e-04 -4.221682e-04 -4.414868e-04
## ASV3024     -1.221441e-04 -1.280434e-04 -1.342288e-04 -1.407140e-04
## ASV8715     -3.002245e-04 -3.140275e-04 -3.284419e-04 -3.434928e-04
## ASV6917     -1.268433e-04 -1.322920e-04 -1.379480e-04 -1.438169e-04
## ASV1132      3.109208e-04  3.254751e-04  3.406986e-04  3.566212e-04
## ASV3583      1.564198e-04  1.638115e-04  1.715497e-04  1.796503e-04
## ASV0328      4.959076e-04  5.187784e-04  5.426695e-04  5.676232e-04
## ASV0915     -1.663486e-04 -1.741665e-04 -1.823470e-04 -1.909064e-04
## ASV2677      1.683179e-04  1.763093e-04  1.846780e-04  1.934415e-04
## ASV0599      1.699061e-04  1.775548e-04  1.855287e-04  1.938400e-04
## ASV0283     -4.520910e-04 -4.728100e-04 -4.944409e-04 -5.170205e-04
## ASV1028      1.872927e-04  1.960867e-04  2.052873e-04  2.149126e-04
## ASV0523      3.410221e-04  3.568722e-04  3.734399e-04  3.907561e-04
## ASV8201     -2.078217e-04 -2.175050e-04 -2.276284e-04 -2.382109e-04
## ASV2795     -6.518221e-05 -6.815090e-05 -7.124862e-05 -7.448043e-05
## ASV3563     -6.507884e-05 -6.804258e-05 -7.113511e-05 -7.436148e-05
## ASV1553     -1.185712e-04 -1.237277e-04 -1.290866e-04 -1.346537e-04
## ASV7155     -3.336035e-05 -3.526366e-05 -3.728236e-05 -3.942361e-05
## ASV0365      4.361607e-04  4.560246e-04  4.767521e-04  4.983768e-04
## ASV8583     -2.998483e-04 -3.135134e-04 -3.277726e-04 -3.426490e-04
## ASV5400      1.596257e-05  1.674144e-05  1.755825e-05  1.841478e-05
## ASV5908      2.317788e-04  2.420853e-04  2.528160e-04  2.639852e-04
## ASV2075      1.313550e-04  1.374746e-04  1.438724e-04  1.505604e-04
## ASV2520     -2.620208e-04 -2.742414e-04 -2.870196e-04 -3.003797e-04
## ASV9596     -1.286866e-04 -1.343655e-04 -1.402744e-04 -1.464209e-04
## ASV1131     -4.290695e-05 -4.461936e-05 -4.638522e-05 -4.820489e-05
## ASV0579     -8.519127e-05 -8.906803e-05 -9.311320e-05 -9.733340e-05
## ASV0288     -4.167540e-04 -4.356602e-04 -4.553812e-04 -4.759481e-04
## ASV4053      6.855895e-05  7.133343e-05  7.419716e-05  7.715089e-05
## ASV1736     -2.226258e-04 -2.328347e-04 -2.434931e-04 -2.546191e-04
## ASV1254      2.290761e-04  2.392940e-04  2.499365e-04  2.610184e-04
## ASV9038     -3.644162e-04 -3.812645e-04 -3.988669e-04 -4.172550e-04
## ASV4746      3.325850e-04  3.481497e-04  3.644299e-04  3.814574e-04
## ASV5803      1.260783e-04  1.319028e-04  1.379880e-04  1.443448e-04
## ASV0525      1.449175e-05  1.519347e-05  1.592956e-05  1.670173e-05
## ASV1974      1.919345e-04  2.004271e-04  2.092653e-04  2.184603e-04
## ASV1827      3.217389e-04  3.361914e-04  3.512532e-04  3.669464e-04
## ASV30780     1.573000e-05  1.633046e-05  1.694592e-05  1.757587e-05
## ASV9342      1.197407e-05  1.266492e-05  1.339963e-05  1.418125e-05
## ASV21626    -3.043411e-04 -3.182369e-04 -3.327389e-04 -3.478708e-04
## ASV1232     -2.152511e-04 -2.249962e-04 -2.351593e-04 -2.457560e-04
## ASV5578     -2.174915e-04 -2.275323e-04 -2.380216e-04 -2.489781e-04
## ASV5868      2.281972e-04  2.383312e-04  2.488826e-04  2.598657e-04
## ASV13625    -9.454965e-05 -9.881505e-05 -1.032616e-04 -1.078960e-04
## ASV3614      3.501787e-05  3.646253e-05  3.795632e-05  3.949994e-05
## ASV2128      1.965507e-04  2.057028e-04  2.152707e-04  2.252724e-04
## ASV5086      4.293105e-05  4.484446e-05  4.683680e-05  4.891073e-05
## ASV6614     -2.174816e-04 -2.275214e-04 -2.380097e-04 -2.489650e-04
## ASV9451     -2.174637e-04 -2.275019e-04 -2.379883e-04 -2.489416e-04
## ASV9533     -2.174459e-04 -2.274823e-04 -2.379669e-04 -2.489182e-04
## ASV10697     2.777381e-06  3.036951e-06  3.320245e-06  3.629357e-06
## ASV1473     -1.018469e-04 -1.063062e-04 -1.109426e-04 -1.157616e-04
## ASV1414     -6.453091e-05 -6.756617e-05 -7.074113e-05 -7.406185e-05
## ASV1567     -6.334805e-05 -6.650379e-05 -6.982227e-05 -7.331231e-05
## ASV6395     -2.193053e-04 -2.295196e-04 -2.401989e-04 -2.513633e-04
## ASV2366      8.798756e-05  9.167781e-05  9.549870e-05  9.945257e-05
## ASV2537      8.780565e-05  9.155720e-05  9.544911e-05  9.948486e-05
## ASV5378     -2.192965e-04 -2.295099e-04 -2.401882e-04 -2.513515e-04
## ASV5929     -2.307958e-04 -2.415356e-04 -2.527633e-04 -2.645000e-04
## ASV6360      1.830254e-04  1.912094e-04  1.997341e-04  2.086113e-04
## ASV7916     -3.724763e-05 -3.913213e-05 -4.111667e-05 -4.320693e-05
## ASV13322     7.285497e-05  7.636082e-05  8.003651e-05  8.389030e-05
## ASV6207     -2.773961e-04 -2.901423e-04 -3.034521e-04 -3.173485e-04
## ASV8823     -2.208054e-04 -2.310086e-04 -2.416683e-04 -2.528037e-04
## ASV1379      3.072908e-04  3.214351e-04  3.362072e-04  3.516327e-04
## ASV3259     -3.072656e-04 -3.214076e-04 -3.361771e-04 -3.515998e-04
## ASV18748     9.128712e-07  1.086713e-06  1.280800e-06  1.497158e-06
## ASV3570      6.681406e-05  6.992285e-05  7.317270e-05  7.656964e-05
## ASV0790     -6.621389e-05 -6.866087e-05 -7.116328e-05 -7.371885e-05
## ASV5149     -2.807646e-04 -2.935779e-04 -3.069496e-04 -3.209016e-04
## ASV1730     -2.897976e-04 -3.030760e-04 -3.169380e-04 -3.314072e-04
## ASV3488     -2.373928e-05 -2.475331e-05 -2.580536e-05 -2.689640e-05
## ASV5486     -3.142552e-04 -3.290645e-04 -3.445642e-04 -3.607859e-04
## ASV1319      4.939116e-05  5.105313e-05  5.273460e-05  5.443174e-05
## ASV15328    -2.160792e-04 -2.259894e-04 -2.363363e-04 -2.471377e-04
## ASV5994      3.120189e-04  3.263692e-04  3.413553e-04  3.570032e-04
## ASV4992     -2.502138e-05 -2.609875e-05 -2.721707e-05 -2.837738e-05
## ASV1788     -3.409000e-04 -3.560519e-04 -3.718283e-04 -3.882506e-04
## ASV3264     -3.903322e-06 -3.897141e-06 -3.873412e-06 -3.829819e-06
## ASV4895      1.465304e-05  1.524230e-05  1.584980e-05  1.647558e-05
## ASV9218     -5.422797e-06 -5.475606e-06 -5.512530e-06 -5.531245e-06
## ASV0736     -6.625248e-06 -7.112301e-06 -7.637806e-06 -8.204881e-06
## ASV0916      2.160365e-04  2.259428e-04  2.362856e-04  2.470824e-04
## ASV15761    -2.160189e-04 -2.259235e-04 -2.362645e-04 -2.470593e-04
## ASV4191      2.691943e-04  2.813070e-04  2.939320e-04  3.070881e-04
## ASV3268     -5.519900e-05 -5.757530e-05 -6.004173e-05 -6.260054e-05
## ASV15321    -3.521935e-05 -3.700494e-05 -3.888522e-05 -4.086552e-05
## ASV0708     -2.158488e-04 -2.259301e-04 -2.364728e-04 -2.474971e-04
## ASV4100      2.544791e-05  2.646818e-05  2.751989e-05  2.860305e-05
## ASV1627      1.734535e-04  1.808903e-04  1.886100e-04  1.966202e-04
## ASV7045     -1.911357e-04 -1.999534e-04 -2.091639e-04 -2.187832e-04
## ASV3271      4.579711e-05  4.742381e-05  4.908234e-05  5.077085e-05
## ASV6200     -3.327681e-05 -3.487668e-05 -3.655438e-05 -3.831381e-05
## ASV2727     -2.256776e-04 -2.364034e-04 -2.476358e-04 -2.593981e-04
## ASV3523     -2.987854e-04 -3.124293e-04 -3.266685e-04 -3.415265e-04
## ASV2259      2.016515e-04  2.109154e-04  2.205891e-04  2.306894e-04
## ASV0181      2.963201e-04  3.097721e-04  3.238043e-04  3.384389e-04
## ASV1680      5.936118e-04  6.207908e-04  6.491630e-04  6.787760e-04
## ASV0176      6.038365e-05  6.300624e-05  6.573048e-05  6.855917e-05
## ASV10458    -2.168912e-04 -2.268767e-04 -2.373059e-04 -2.481969e-04
## ASV10658    -2.168734e-04 -2.268573e-04 -2.372846e-04 -2.481736e-04
## ASV16807    -2.168557e-04 -2.268378e-04 -2.372633e-04 -2.481503e-04
## ASV2113     -2.168379e-04 -2.268184e-04 -2.372421e-04 -2.481271e-04
## ASV2403      2.223782e-04  2.324734e-04  2.430036e-04  2.539855e-04
## ASV2484     -2.168305e-04 -2.268103e-04 -2.372332e-04 -2.481173e-04
## ASV8876     -2.168128e-04 -2.267909e-04 -2.372119e-04 -2.480941e-04
## ASV0386      3.171797e-04  3.319777e-04  3.474515e-04  3.636304e-04
## ASV0351      8.748836e-05  9.137627e-05  9.542369e-05  9.963595e-05
## ASV4942     -1.235476e-04 -1.292004e-04 -1.351015e-04 -1.412609e-04
## ASV5128     -9.574047e-05 -1.002063e-04 -1.048755e-04 -1.097570e-04
## ASV3496      1.074671e-04  1.126936e-04  1.181785e-04  1.239348e-04
## ASV3329      3.157341e-04  3.304250e-04  3.457828e-04  3.618361e-04
## ASV7878     -2.160744e-04 -2.259810e-04 -2.363235e-04 -2.471196e-04
## ASV8251     -8.208324e-05 -8.584403e-05 -8.976991e-05 -9.386743e-05
## ASV15958    -7.094251e-05 -7.424353e-05 -7.769423e-05 -8.130101e-05
## ASV7972     -3.089266e-04 -3.232252e-04 -3.381657e-04 -3.537753e-04
## ASV2088      3.089012e-04  3.231973e-04  3.381352e-04  3.537419e-04
## ASV3054     -1.453998e-04 -1.521319e-04 -1.591662e-04 -1.665154e-04
## ASV4494     -3.088656e-04 -3.231583e-04 -3.380926e-04 -3.536952e-04
## ASV0087     -5.853982e-04 -6.121899e-04 -6.401566e-04 -6.693454e-04
## ASV1614     -2.393311e-04 -2.502669e-04 -2.616805e-04 -2.735908e-04
## ASV3037     -1.325881e-04 -1.386830e-04 -1.450479e-04 -1.516935e-04
## ASV6615     -3.477589e-05 -3.654059e-05 -3.839868e-05 -4.035535e-05
## ASV1027      8.982694e-05  9.387807e-05  9.810108e-05  1.025023e-04
## ASV2754     -5.609802e-05 -5.886336e-05 -6.176835e-05 -6.482023e-05
## ASV0536     -4.380565e-05 -4.592073e-05 -4.813880e-05 -5.046491e-05
## ASV2318     -9.278519e-05 -9.716034e-05 -1.017397e-04 -1.065326e-04
## ASV5954      1.841865e-04  1.923187e-04  2.007808e-04  2.095839e-04
## ASV9028      1.297182e-04  1.357088e-04  1.419670e-04  1.485039e-04
## ASV6600     -2.193987e-04 -2.296201e-04 -2.403069e-04 -2.514792e-04
## ASV1923     -5.775855e-05 -6.034548e-05 -6.304030e-05 -6.584676e-05
## ASV4034     -4.245669e-05 -4.466780e-05 -4.700084e-05 -4.946296e-05
## ASV9933     -2.193734e-04 -2.295924e-04 -2.402764e-04 -2.514458e-04
## ASV1575      4.109726e-05  4.285539e-05  4.468015e-05  4.657335e-05
## ASV7812     -3.728618e-04 -3.899662e-04 -4.078241e-04 -4.264661e-04
## ASV0515      2.400316e-04  2.507856e-04  2.619899e-04  2.736605e-04
## ASV1149     -2.726083e-05 -2.886231e-05 -3.056608e-05 -3.237908e-05
## ASV3791      1.003106e-04  1.050563e-04  1.100249e-04  1.152265e-04
## ASV4065     -3.487396e-04 -3.647681e-04 -3.815055e-04 -3.989804e-04
## ASV10631    -1.976150e-05 -2.083456e-05 -2.197076e-05 -2.317418e-05
## ASV2359     -3.446772e-04 -3.599085e-04 -3.757598e-04 -3.922518e-04
## ASV3206     -2.170558e-04 -2.270590e-04 -2.375079e-04 -2.484207e-04
## ASV4415      1.766828e-04  1.848245e-04  1.933281e-04  2.022085e-04
## ASV4467     -1.555702e-04 -1.626596e-04 -1.700572e-04 -1.777751e-04
## ASV5598      2.661789e-04  2.787537e-04  2.919175e-04  3.056975e-04
## ASV5910     -2.394672e-04 -2.505227e-04 -2.620724e-04 -2.741371e-04
## ASV9494     -2.170073e-04 -2.270060e-04 -2.374498e-04 -2.483571e-04
## ASV6548     -1.772171e-04 -1.853514e-04 -1.938451e-04 -2.027127e-04
## ASV8669     -2.169752e-04 -2.269709e-04 -2.374114e-04 -2.483151e-04
## ASV0674      1.348631e-04  1.408250e-04  1.470287e-04  1.534820e-04
## ASV0061     -6.512211e-05 -6.875295e-05 -7.260130e-05 -7.668092e-05
## ASV0310     -1.342222e-04 -1.402090e-04 -1.464471e-04 -1.529457e-04
## ASV0582      4.136624e-05  4.305699e-05  4.480386e-05  4.660753e-05
## ASV0739      4.111674e-04  4.303180e-04  4.503391e-04  4.712682e-04
## ASV1557      1.717273e-04  1.798789e-04  1.884155e-04  1.973551e-04
## ASV0146      3.838193e-04  4.008658e-04  4.186131e-04  4.370851e-04
## ASV3832      3.919962e-04  4.096847e-04  4.281257e-04  4.473468e-04
## ASV0734      8.771187e-05  9.182628e-05  9.612983e-05  1.006308e-04
## ASV3036     -2.873700e-04 -3.007713e-04 -3.147841e-04 -3.294353e-04
## ASV0240      7.722173e-05  8.070154e-05  8.432896e-05  8.810940e-05
## ASV2513     -4.312087e-04 -4.508043e-04 -4.712468e-04 -4.925689e-04
## ASV1118     -1.148773e-04 -1.203397e-04 -1.260599e-04 -1.320498e-04
## ASV7286     -2.164182e-04 -2.263591e-04 -2.367394e-04 -2.475771e-04
## ASV1077      2.890636e-04  3.021189e-04  3.157312e-04  3.299215e-04
## ASV1255     -2.163802e-04 -2.263175e-04 -2.366939e-04 -2.475274e-04
## ASV1794     -1.312261e-05 -1.375821e-05 -1.442484e-05 -1.512400e-05
## ASV2439     -2.163632e-04 -2.262990e-04 -2.366737e-04 -2.475053e-04
## ASV2467     -2.163455e-04 -2.262796e-04 -2.366525e-04 -2.474821e-04
## ASV3346     -2.163279e-04 -2.262603e-04 -2.366314e-04 -2.474590e-04
## ASV3973     -2.163102e-04 -2.262409e-04 -2.366102e-04 -2.474359e-04
## ASV4521      9.555845e-05  9.985678e-05  1.043362e-04  1.090031e-04
## ASV1909     -2.572070e-04 -2.692891e-04 -2.819304e-04 -2.951560e-04
## ASV3855     -1.938723e-04 -2.026998e-04 -2.119102e-04 -2.215184e-04
## ASV0810      2.587382e-04  2.706958e-04  2.831886e-04  2.962388e-04
## ASV1765      3.085636e-04  3.229413e-04  3.379738e-04  3.536894e-04
## ASV0763      1.677375e-04  1.754263e-04  1.834534e-04  1.918326e-04
## ASV0302     -1.828900e-04 -1.911619e-04 -1.997875e-04 -2.087798e-04
## ASV2643     -2.490409e-04 -2.600552e-04 -2.715200e-04 -2.834507e-04
## ASV0440      9.665448e-05  1.012008e-04  1.059569e-04  1.109320e-04
## ASV4899     -1.752809e-04 -1.830528e-04 -1.911423e-04 -1.995599e-04
## ASV0287     -1.065346e-04 -1.114938e-04 -1.166788e-04 -1.220995e-04
## ASV3220      1.333151e-04  1.395529e-04  1.460764e-04  1.528980e-04
## ASV1007     -7.663603e-05 -8.000368e-05 -8.350600e-05 -8.714712e-05
## ASV2929     -4.888220e-05 -5.094287e-05 -5.307777e-05 -5.528839e-05
## ASV1496     -1.836953e-04 -1.923164e-04 -2.013358e-04 -2.107714e-04
## ASV4975      8.027407e-05  8.399596e-05  8.788503e-05  9.194822e-05
## ASV4392     -1.108204e-05 -1.139273e-05 -1.169820e-05 -1.199640e-05
## ASV4653     -2.187620e-04 -2.289237e-04 -2.395452e-04 -2.506463e-04
## ASV0230     -1.120112e-04 -1.172751e-04 -1.227826e-04 -1.285447e-04
## ASV0840      1.578238e-04  1.651406e-04  1.727873e-04  1.807780e-04
## ASV4132     -4.716355e-05 -4.943207e-05 -5.181042e-05 -5.430394e-05
## ASV3344      1.644107e-04  1.718034e-04  1.795084e-04  1.875370e-04
## ASV12096    -2.218696e-04 -2.322092e-04 -2.430187e-04 -2.543185e-04
## ASV1550      7.394453e-05  7.704941e-05  8.026519e-05  8.359404e-05
## ASV3542     -3.290008e-04 -3.444479e-04 -3.606071e-04 -3.775099e-04
## ASV8795     -1.273413e-04 -1.332812e-04 -1.394919e-04 -1.459852e-04
## ASV2532     -6.878543e-06 -7.259396e-06 -7.663104e-06 -8.091149e-06
## ASV3087      5.268986e-05  5.501354e-05  5.743112e-05  5.994560e-05
## ASV9476     -1.273339e-04 -1.332730e-04 -1.394830e-04 -1.459754e-04
## ASV13721    -1.273233e-04 -1.332615e-04 -1.394703e-04 -1.459615e-04
## ASV3842      2.096309e-04  2.190310e-04  2.288255e-04  2.390285e-04
## ASV1663      3.773275e-04  3.942607e-04  4.119060e-04  4.302892e-04
## ASV0432      8.869790e-05  9.267186e-05  9.681227e-05  1.011251e-04
## ASV4356      3.734149e-04  3.905348e-04  4.084085e-04  4.270664e-04
## ASV4524      9.086743e-05  9.520565e-05  9.975093e-05  1.045131e-04
## ASV0169     -1.843994e-04 -1.930656e-04 -2.021331e-04 -2.116195e-04
## ASV0368     -1.584968e-04 -1.659386e-04 -1.737242e-04 -1.818687e-04
## ASV2603      7.424987e-08  7.668190e-08  7.869425e-08  8.015904e-08
## ASV3777      2.090340e-04  2.186798e-04  2.287559e-04  2.392801e-04
## ASV3978      1.814672e-04  1.897291e-04  1.983489e-04  2.073404e-04
## ASV0413     -1.495591e-04 -1.565764e-04 -1.639173e-04 -1.715962e-04
## ASV0997     -4.540442e-08 -4.511248e-08 -4.414819e-08 -4.236102e-08
## ASV1195     -4.540393e-08 -4.511305e-08 -4.415016e-08 -4.236484e-08
## ASV2522     -9.838588e-05 -1.029011e-04 -1.076157e-04 -1.125375e-04
## ASV4733      1.797086e-04  1.880229e-04  1.967099e-04  2.057851e-04
## ASV1063      3.151654e-04  3.300566e-04  3.456453e-04  3.619636e-04
## ASV0612     -4.018157e-04 -4.205941e-04 -4.402335e-04 -4.607719e-04
## ASV1903     -3.151078e-04 -3.299934e-04 -3.455761e-04 -3.618877e-04
## ASV3576     -9.184047e-05 -9.637599e-05 -1.011419e-04 -1.061502e-04
## ASV4285     -2.245470e-04 -2.350562e-04 -2.460478e-04 -2.575429e-04
## ASV3406     -1.167680e-04 -1.221807e-04 -1.278374e-04 -1.337485e-04
## ASV2379     -2.168643e-04 -2.263515e-04 -2.362162e-04 -2.464703e-04
## ASV0528      2.742453e-04  2.869582e-04  3.002434e-04  3.141251e-04
## ASV6190     -3.565360e-05 -3.738923e-05 -3.921060e-05 -4.112199e-05
## ASV1537     -2.826926e-06 -2.854085e-06 -2.872475e-06 -2.880761e-06
## ASV16780    -2.439048e-04 -2.550773e-04 -2.667410e-04 -2.789156e-04
## ASV0477      6.057235e-04  6.336477e-04  6.628158e-04  6.932790e-04
## ASV1499      1.388124e-04  1.456236e-04  1.527755e-04  1.602853e-04
## ASV14736     1.050981e-04  1.098892e-04  1.148890e-04  1.201059e-04
## ASV0179     -8.738256e-05 -9.145842e-05 -9.572015e-05 -1.001758e-04
## ASV3153      7.443626e-06  8.051342e-06  8.710997e-06  9.427066e-06
## ASV0266      2.830959e-04  2.962541e-04  3.100090e-04  3.243863e-04
## ASV0761      4.190754e-04  4.381816e-04  4.581197e-04  4.789226e-04
## ASV0269     -4.121738e-05 -4.335629e-05 -4.561314e-05 -4.799497e-05
## ASV7259     -7.948813e-05 -8.343780e-05 -8.758867e-05 -9.195122e-05
## ASV2067     -8.876022e-05 -9.271402e-05 -9.683140e-05 -1.011180e-04
## ASV2985     -2.486124e-04 -2.600812e-04 -2.720602e-04 -2.845702e-04
## ASV0975     -3.769367e-04 -3.944525e-04 -4.127614e-04 -4.318973e-04
## ASV2240      2.241273e-04  2.341833e-04  2.446626e-04  2.555807e-04
## ASV2297      7.282725e-05  7.589568e-05  7.907503e-05  8.236769e-05
## ASV2657      9.427290e-05  9.844347e-05  1.027844e-04  1.073014e-04
## ASV3784      3.396406e-06  3.711185e-06  4.054329e-06  4.428280e-06
## ASV4333      3.395869e-06  3.710571e-06  4.053628e-06  4.427480e-06
## ASV5547      1.934092e-04  2.018605e-04  2.106474e-04  2.197805e-04
## ASV5813      7.849665e-05  8.194960e-05  8.554137e-05  8.927637e-05
## ASV8049      9.412908e-05  9.838913e-05  1.028320e-04  1.074646e-04
## ASV8661     -3.405481e-06 -3.721040e-06 -4.065027e-06 -4.439887e-06
## ASV9510      1.099853e-04  1.149394e-04  1.201035e-04  1.254853e-04
## ASV1401      5.772964e-05  6.030717e-05  6.299211e-05  6.578827e-05
## ASV1417     -1.151711e-04 -1.200047e-04 -1.250113e-04 -1.301944e-04
## ASV2169      4.014016e-04  4.198185e-04  4.390481e-04  4.591235e-04
## ASV5354     -3.417451e-06 -3.734128e-06 -4.079334e-06 -4.455525e-06
## ASV5379     -3.416911e-06 -3.733511e-06 -4.078630e-06 -4.454721e-06
## ASV6078     -3.416371e-06 -3.732894e-06 -4.077925e-06 -4.453916e-06
## ASV6417      2.453316e-04  2.564275e-04  2.679981e-04  2.800613e-04
## ASV8304      1.777684e-04  1.856680e-04  1.938931e-04  2.024546e-04
## ASV8766     -3.436996e-06 -3.755391e-06 -4.102457e-06 -4.480660e-06
## ASV10861     7.422667e-05  7.748155e-05  8.086610e-05  8.438432e-05
## ASV2057      3.969419e-04  4.151773e-04  4.342192e-04  4.541002e-04
## ASV4499      1.391186e-04  1.451565e-04  1.514294e-04  1.579439e-04
## ASV7415      4.402138e-05  4.606996e-05  4.821088e-05  5.044795e-05
## ASV2475     -1.702020e-04 -1.780682e-04 -1.862869e-04 -1.948729e-04
## ASV3517     -2.785502e-04 -2.916295e-04 -3.053139e-04 -3.196308e-04
## ASV1864      1.867291e-04  1.951400e-04  2.039073e-04  2.130440e-04
## ASV2756      2.157039e-04  2.255784e-04  2.358863e-04  2.466451e-04
## ASV0778      2.156863e-04  2.255591e-04  2.358653e-04  2.466222e-04
## ASV3201      4.930993e-05  5.184574e-05  5.451901e-05  5.733771e-05
## ASV3358      2.156714e-04  2.255429e-04  2.358476e-04  2.466028e-04
## ASV5681     -2.156538e-04 -2.255237e-04 -2.358266e-04 -2.465798e-04
## ASV7256      1.045103e-04  1.093647e-04  1.144400e-04  1.197461e-04
## ASV1704     -2.204610e-04 -2.304817e-04 -2.409350e-04 -2.518375e-04
## ASV4445      3.466542e-04  3.619365e-04  3.778374e-04  3.943773e-04
## ASV8649     -2.156178e-04 -2.254844e-04 -2.357837e-04 -2.465330e-04
## ASV0597      2.241034e-04  2.343519e-04  2.450493e-04  2.562135e-04
## ASV0861      2.852874e-04  2.982197e-04  3.117080e-04  3.257734e-04
## ASV2423      3.461197e-04  3.618715e-04  3.783055e-04  3.954481e-04
## ASV1548      1.686288e-04  1.759634e-04  1.835849e-04  1.915014e-04
## ASV2564      2.880030e-04  3.009695e-04  3.144843e-04  3.285673e-04
## ASV2999      4.790563e-04  5.005537e-04  5.229551e-04  5.462928e-04
## ASV4543     -1.729691e-04 -1.810863e-04 -1.895788e-04 -1.984635e-04
## ASV8452      1.644071e-04  1.716867e-04  1.792631e-04  1.871460e-04
## ASV17287    -3.466006e-05 -3.644297e-05 -3.832279e-05 -4.030518e-05
## ASV3503     -2.213515e-04 -2.317598e-04 -2.426511e-04 -2.540474e-04
## ASV4727     -3.812395e-05 -4.012779e-05 -4.224389e-05 -4.447902e-05
## ASV5995     -1.883175e-04 -1.971584e-04 -2.064084e-04 -2.160857e-04
## ASV1665     -6.030534e-05 -6.313267e-05 -6.609033e-05 -6.918412e-05
## ASV2690     -2.817268e-04 -2.947166e-04 -3.082854e-04 -3.224571e-04
## ASV2823     -2.288704e-05 -2.389088e-05 -2.493492e-05 -2.602047e-05
## ASV5241     -3.767085e-04 -3.940736e-04 -4.122116e-04 -4.311541e-04
## ASV5473     -1.082944e-04 -1.134334e-04 -1.188152e-04 -1.244511e-04
## ASV2785      4.890403e-05  5.126628e-05  5.374364e-05  5.634175e-05
## ASV6645     -1.591512e-04 -1.664233e-04 -1.740132e-04 -1.819334e-04
## ASV0562      6.426067e-05  6.700917e-05  6.985964e-05  7.281435e-05
## ASV1163      6.507429e-05  6.812335e-05  7.131245e-05  7.464771e-05
## ASV1825      1.227133e-04  1.282417e-04  1.340040e-04  1.400086e-04
## ASV3795      2.710459e-04  2.834065e-04  2.963059e-04  3.097652e-04
## ASV3869     -6.087778e-05 -6.384186e-05 -6.695290e-05 -7.021840e-05
## ASV4330      2.089820e-04  2.185701e-04  2.285809e-04  2.390315e-04
## ASV6754      7.944125e-05  8.308354e-05  8.688600e-05  9.085502e-05
## ASV4598     -2.151652e-06 -2.356496e-06 -2.580559e-06 -2.825600e-06
## ASV2100      1.604196e-04  1.675785e-04  1.750349e-04  1.827994e-04
## ASV3518      7.973426e-05  8.328289e-05  8.697746e-05  9.082282e-05
## ASV3823      3.304184e-04  3.454056e-04  3.610381e-04  3.773403e-04
## ASV7357      2.028351e-04  2.121012e-04  2.217723e-04  2.318643e-04
## ASV7403     -2.592090e-04 -2.709987e-04 -2.832987e-04 -2.961287e-04
## ASV2934     -1.106058e-05 -1.148548e-05 -1.192132e-05 -1.236779e-05
## ASV5277     -1.349364e-04 -1.410702e-04 -1.474689e-04 -1.541427e-04
## ASV0281     -3.975871e-04 -4.157371e-04 -4.346796e-04 -4.544460e-04
## ASV11181    -1.479608e-04 -1.550268e-04 -1.624312e-04 -1.701904e-04
## ASV0254     -5.144325e-05 -5.339195e-05 -5.538803e-05 -5.742980e-05
## ASV0201     -6.880843e-05 -7.217283e-05 -7.570541e-05 -7.941489e-05
## ASV3656     -1.706728e-04 -1.788996e-04 -1.875267e-04 -1.965738e-04
## ASV7994     -3.072664e-04 -3.214262e-04 -3.362165e-04 -3.516631e-04
## ASV3584     -9.956505e-05 -1.037166e-04 -1.080151e-04 -1.124633e-04
## ASV2157      3.157679e-04  3.299807e-04  3.447960e-04  3.602361e-04
## ASV2935     -4.065484e-05 -4.253509e-05 -4.449965e-05 -4.655204e-05
## ASV9024     -2.876784e-04 -3.007112e-04 -3.143035e-04 -3.284764e-04
## ASV7711      1.723401e-04  1.804721e-04  1.889841e-04  1.978933e-04
## ASV11330    -2.181673e-04 -2.282742e-04 -2.388360e-04 -2.498721e-04
## ASV1875      1.922110e-04  2.010534e-04  2.102888e-04  2.199332e-04
## ASV5861      1.441065e-04  1.509113e-04  1.580341e-04  1.654895e-04
## ASV11562     1.262558e-05  1.323411e-05  1.387198e-05  1.454057e-05
## ASV18559    -2.181615e-04 -2.282678e-04 -2.388290e-04 -2.498645e-04
## ASV4384      2.112543e-04  2.212067e-04  2.316225e-04  2.425226e-04
## ASV1302      4.304862e-04  4.496150e-04  4.695333e-04  4.902685e-04
## ASV4673     -2.865981e-04 -2.999676e-04 -3.139466e-04 -3.285616e-04
## ASV1956      4.791898e-05  4.990657e-05  5.196474e-05  5.409510e-05
## ASV3286      1.999035e-04  2.093292e-04  2.191941e-04  2.295183e-04
## ASV4866     -3.135365e-04 -3.282773e-04 -3.437022e-04 -3.598420e-04
## ASV3129     -1.538366e-04 -1.610187e-04 -1.685296e-04 -1.763837e-04
## ASV4104      3.535456e-04  3.697834e-04  3.867386e-04  4.044405e-04
## ASV8983      2.885218e-06  3.016821e-06  3.154520e-06  3.298640e-06
## ASV2201      1.351473e-04  1.411100e-04  1.473139e-04  1.537669e-04
## ASV3055      9.244486e-05  9.637315e-05  1.004468e-04  1.046693e-04
## ASV0534     -4.607325e-04 -4.817069e-04 -5.035904e-04 -5.264184e-04
## ASV1019      1.550666e-05  1.639052e-05  1.732952e-05  1.832739e-05
## ASV18482    -2.143304e-04 -2.240754e-04 -2.342419e-04 -2.448460e-04
## ASV2694      7.143481e-05  7.447648e-05  7.763117e-05  8.090162e-05
## ASV3412     -6.584816e-05 -6.870079e-05 -7.166335e-05 -7.473878e-05
## ASV4174     -2.143088e-04 -2.240518e-04 -2.342161e-04 -2.448179e-04
## ASV4281     -2.142914e-04 -2.240328e-04 -2.341953e-04 -2.447953e-04
## ASV4949      2.404089e-04  2.511717e-04  2.623849e-04  2.740648e-04
## ASV5881      1.129847e-04  1.180969e-04  1.234277e-04  1.289854e-04
## ASV6299     -9.500936e-05 -9.922966e-05 -1.036232e-04 -1.081957e-04
## ASV0676      2.459997e-04  2.571043e-04  2.686825e-04  2.807521e-04
## ASV1066     -1.677910e-04 -1.753188e-04 -1.831624e-04 -1.913332e-04
## ASV1300     -1.435270e-04 -1.500168e-04 -1.567838e-04 -1.638382e-04
## ASV6455      7.005032e-05  7.327632e-05  7.664580e-05  8.016467e-05
## ASV3455     -2.142863e-04 -2.240272e-04 -2.341892e-04 -2.447886e-04
## ASV6531     -2.142690e-04 -2.240083e-04 -2.341685e-04 -2.447660e-04
## ASV0490      4.283822e-04  4.475938e-04  4.676154e-04  4.884768e-04
## ASV2588      2.343976e-05  2.486813e-05  2.639180e-05  2.801754e-05
## ASV5364      1.349411e-04  1.410454e-04  1.474107e-04  1.540466e-04
## ASV0981     -2.993739e-04 -3.133244e-04 -3.279102e-04 -3.431588e-04
## ASV1563     -6.147401e-05 -6.434499e-05 -6.734762e-05 -7.048776e-05
## ASV0376     -2.872353e-04 -3.006156e-04 -3.146045e-04 -3.292281e-04
## ASV7308     -1.579799e-06 -1.733090e-06 -1.901190e-06 -2.085517e-06
## ASV4817      4.598019e-05  4.790762e-05  4.990311e-05  5.196785e-05
## ASV8716     -3.038543e-04 -3.170108e-04 -3.306796e-04 -3.448757e-04
## ASV1849      3.874649e-04  4.045055e-04  4.222310e-04  4.406631e-04
## ASV9423     -2.996219e-04 -3.132046e-04 -3.273717e-04 -3.421455e-04
## ASV7690      1.130848e-05  1.186557e-05  1.245036e-05  1.306422e-05
## ASV4901      1.655454e-04  1.732227e-04  1.812460e-04  1.896299e-04
## ASV1830     -5.298129e-05 -5.580674e-05 -5.879340e-05 -6.195116e-05
## ASV2316     -2.226306e-04 -2.322981e-04 -2.423461e-04 -2.527863e-04
## ASV0693      3.317602e-04  3.470831e-04  3.630909e-04  3.798120e-04
## ASV1243     -1.822045e-05 -1.883297e-05 -1.945206e-05 -2.007615e-05
## ASV3867      8.738413e-05  9.148927e-05  9.578421e-05  1.002774e-04
## ASV7932      1.880890e-04  1.967610e-04  2.058190e-04  2.152787e-04
## ASV12608     1.361176e-04  1.426324e-04  1.494599e-04  1.566151e-04
## ASV1661      1.969194e-04  2.059168e-04  2.153071e-04  2.251061e-04
## ASV3957      2.071346e-04  2.167475e-04  2.267951e-04  2.372959e-04
## ASV0830     -3.265190e-04 -3.414085e-04 -3.569467e-04 -3.731590e-04
## ASV2078      3.709123e-04  3.879597e-04  4.057626e-04  4.243520e-04
## ASV13932    -2.188716e-04 -2.290446e-04 -2.396786e-04 -2.507935e-04
## ASV5300     -2.188535e-04 -2.290248e-04 -2.396569e-04 -2.507698e-04
## ASV1014     -1.175944e-04 -1.229512e-04 -1.285403e-04 -1.343707e-04
## ASV13059    -6.785500e-05 -7.127168e-05 -7.486667e-05 -7.864966e-05
## ASV4340      4.446510e-05  4.643846e-05  4.849325e-05  5.063232e-05
## ASV5591     -3.641365e-04 -3.807253e-04 -3.980346e-04 -4.160926e-04
## ASV6040     -2.911441e-04 -3.044637e-04 -3.183670e-04 -3.328769e-04
## ASV3904     -1.206413e-04 -1.263171e-04 -1.322562e-04 -1.384704e-04
## ASV2267     -3.404808e-05 -3.562267e-05 -3.726749e-05 -3.898539e-05
## ASV0573     -2.722604e-04 -2.843718e-04 -2.969827e-04 -3.101104e-04
## ASV0851     -2.937525e-04 -3.071909e-04 -3.212177e-04 -3.358561e-04
## ASV7805      9.204629e-05  9.642095e-05  1.010029e-04  1.058017e-04
## ASV3379      3.927708e-04  4.104212e-04  4.288173e-04  4.479866e-04
## ASV0825      1.780715e-04  1.865158e-04  1.953576e-04  2.046152e-04
## ASV2461      2.056079e-04  2.149311e-04  2.246558e-04  2.347972e-04
## ASV2783      2.870449e-04  3.001691e-04  3.138679e-04  3.281640e-04
## ASV0925      3.214162e-04  3.358867e-04  3.509696e-04  3.666874e-04
## ASV7023     -3.065115e-04 -3.207268e-04 -3.355830e-04 -3.511075e-04
## ASV5319      5.573913e-05  5.836327e-05  6.110867e-05  6.398064e-05
## ASV3213      1.913284e-04  2.002179e-04  2.095092e-04  2.192195e-04
## ASV3748     -4.764450e-05 -5.001007e-05 -5.249714e-05 -5.511227e-05
## ASV5491     -6.983584e-05 -7.322653e-05 -7.678463e-05 -8.051862e-05
## ASV7931      1.205063e-04  1.260832e-04  1.319102e-04  1.379976e-04
## ASV12767    -2.198780e-04 -2.301462e-04 -2.408844e-04 -2.521132e-04
## ASV6389      2.215563e-04  2.318710e-04  2.426548e-04  2.539278e-04
## ASV14867    -2.198594e-04 -2.301259e-04 -2.408622e-04 -2.520888e-04
## ASV5105      1.280826e-04  1.341468e-04  1.404957e-04  1.471423e-04
## ASV15927    -2.191257e-04 -2.293211e-04 -2.399794e-04 -2.511205e-04
## ASV2004      7.522092e-05  7.864849e-05  8.222544e-05  8.595771e-05
## ASV5554     -4.361420e-06 -4.982856e-06 -5.670126e-06 -6.429324e-06
## ASV10929    -1.533474e-04 -1.604875e-04 -1.679527e-04 -1.757570e-04
## ASV12778    -7.564865e-05 -7.914771e-05 -8.280386e-05 -8.662373e-05
## ASV14006    -2.190851e-04 -2.292766e-04 -2.399306e-04 -2.510671e-04
## ASV1603      2.142113e-04  2.242145e-04  2.346755e-04  2.456144e-04
## ASV11948     1.102426e-04  1.151331e-04  1.202237e-04  1.255209e-04
## ASV12912    -2.200824e-04 -2.303687e-04 -2.411265e-04 -2.523764e-04
## ASV13147    -2.200642e-04 -2.303487e-04 -2.411045e-04 -2.523523e-04
## ASV14761    -2.200459e-04 -2.303287e-04 -2.410826e-04 -2.523283e-04
## ASV8521      1.760315e-04  1.838732e-04  1.920386e-04  2.005386e-04
## ASV8581     -2.200337e-04 -2.303153e-04 -2.410679e-04 -2.523121e-04
## ASV9875     -3.765349e-05 -3.954552e-05 -4.153660e-05 -4.363223e-05
## ASV9986      1.458564e-04  1.527337e-04  1.599313e-04  1.674640e-04
## ASV2376      2.551825e-04  2.668770e-04  2.790861e-04  2.918303e-04
## ASV17535    -2.200208e-04 -2.303011e-04 -2.410524e-04 -2.522951e-04
## ASV14330    -2.126832e-04 -2.222774e-04 -2.322798e-04 -2.427055e-04
## ASV1333     -4.406027e-04 -4.599409e-04 -4.800538e-04 -5.009661e-04
## ASV2498      1.052601e-04  1.103520e-04  1.156920e-04  1.212921e-04
## ASV6352     -8.682678e-05 -9.064262e-05 -9.461163e-05 -9.873866e-05
## ASV8601     -1.087560e-04 -1.136420e-04 -1.187340e-04 -1.240396e-04
## ASV9776     -8.113297e-05 -8.465122e-05 -8.830590e-05 -9.210082e-05
## ASV1916      1.885619e-04  1.970737e-04  2.059489e-04  2.152012e-04
## ASV1555      2.379120e-05  2.499629e-05  2.626514e-05  2.760132e-05
## ASV2499      2.970704e-04  3.109011e-04  3.253605e-04  3.404757e-04
## ASV0703      2.447608e-04  2.560755e-04  2.678975e-04  2.802479e-04
## ASV2047      3.245928e-04  3.394718e-04  3.550058e-04  3.712214e-04
## ASV5492     -2.207409e-04 -2.310920e-04 -2.419209e-04 -2.532491e-04
## ASV6549     -2.253960e-05 -2.366184e-05 -2.484218e-05 -2.608383e-05
## ASV7757     -7.844590e-05 -8.231964e-05 -8.639024e-05 -9.066814e-05
## ASV0173     -1.871545e-06 -2.047432e-06 -2.239528e-06 -2.449280e-06
## ASV1248     -6.677588e-05 -6.972401e-05 -7.279115e-05 -7.598105e-05
## ASV6502      1.876239e-06  2.052534e-06  2.245070e-06  2.455297e-06
## ASV9844      1.875939e-06  2.052191e-06  2.244677e-06  2.454848e-06
## ASV3903      1.406469e-04  1.472630e-04  1.541861e-04  1.614302e-04
## ASV8199      1.866550e-06  2.041883e-06  2.233361e-06  2.442425e-06
## ASV3309     -9.881329e-06 -1.029513e-05 -1.072323e-05 -1.116579e-05
## ASV5826     -3.239963e-05 -3.399535e-05 -3.567138e-05 -3.743186e-05
## ASV1480     -2.953247e-04 -3.091798e-04 -3.236747e-04 -3.388381e-04
## ASV3090      6.273859e-05  6.558347e-05  6.855070e-05  7.164492e-05
## ASV0758     -1.792458e-04 -1.871145e-04 -1.952986e-04 -2.038079e-04
## ASV0811     -5.406127e-05 -5.644669e-05 -5.892878e-05 -6.151070e-05
## ASV2653      1.463671e-04  1.533097e-04  1.605794e-04  1.681913e-04
## ASV0978      1.513313e-04  1.585263e-04  1.660610e-04  1.739509e-04
## ASV6640     -3.062651e-04 -3.203633e-04 -3.350877e-04 -3.504642e-04
## ASV3423     -1.402374e-05 -1.483806e-05 -1.570487e-05 -1.662792e-05
## ASV0617      3.065795e-04  3.200039e-04  3.339654e-04  3.484811e-04
## ASV14947    -3.095509e-04 -3.239044e-04 -3.389045e-04 -3.545785e-04
## ASV18367    -1.696694e-04 -1.778049e-04 -1.863309e-04 -1.952658e-04
## ASV4574      2.368296e-04  2.472585e-04  2.581071e-04  2.693887e-04
## ASV10514    -1.652537e-04 -1.729978e-04 -1.810983e-04 -1.895708e-04
## ASV11779    -8.268433e-05 -8.695529e-05 -9.145747e-05 -9.620395e-05
## ASV7528     -2.675770e-04 -2.801205e-04 -2.932411e-04 -3.069641e-04
## ASV13153    -1.539330e-04 -1.612049e-04 -1.688166e-04 -1.767836e-04
## ASV7858     -1.366960e-04 -1.431524e-04 -1.499105e-04 -1.569839e-04
## ASV8722      4.668870e-05  4.861050e-05  5.059688e-05  5.264863e-05
## ASV6585     -3.088904e-04 -3.232086e-04 -3.381713e-04 -3.538057e-04
## ASV3311     -2.690664e-04 -2.809747e-04 -2.933676e-04 -3.062608e-04
## ASV2469      4.450082e-06  4.760361e-06  5.093246e-06  5.450342e-06
## ASV11340    -1.336232e-04 -1.395823e-04 -1.457886e-04 -1.522507e-04
## ASV1718      2.525816e-05  2.636001e-05  2.750493e-05  2.869414e-05
## ASV2117     -3.065123e-04 -3.207669e-04 -3.356676e-04 -3.512421e-04
## ASV8252     -2.178154e-04 -2.278891e-04 -2.384147e-04 -2.494113e-04
## ASV8533      4.278595e-05  4.475027e-05  4.680139e-05  4.894285e-05
## ASV9507      3.297324e-05  3.437096e-05  3.581973e-05  3.732064e-05
## ASV0706      1.550014e-04  1.624065e-04  1.701660e-04  1.782969e-04
## ASV10312    -2.177959e-04 -2.278678e-04 -2.383914e-04 -2.493857e-04
## ASV10696    -2.177780e-04 -2.278482e-04 -2.383699e-04 -2.493622e-04
## ASV11203    -2.177601e-04 -2.278286e-04 -2.383484e-04 -2.493387e-04
## ASV12147    -5.216137e-05 -5.468559e-05 -5.733349e-05 -6.011124e-05
## ASV4602     -1.368014e-05 -1.444441e-05 -1.525542e-05 -1.611628e-05
## ASV5568      1.144707e-05  1.204621e-05  1.267849e-05  1.334585e-05
## ASV6777      2.787980e-04  2.917125e-04  3.052082e-04  3.193096e-04
## ASV8749     -2.453856e-04 -2.566094e-04 -2.683250e-04 -2.805521e-04
## ASV4780      4.201906e-05  4.380267e-05  4.565137e-05  4.756651e-05
## ASV10116    -4.126801e-05 -4.315173e-05 -4.511799e-05 -4.717013e-05
## ASV2907      2.375019e-04  2.484429e-04  2.598700e-04  2.718032e-04
## ASV5165      3.091872e-04  3.238914e-04  3.392927e-04  3.554239e-04
## ASV6061      1.726948e-04  1.805469e-04  1.887389e-04  1.972840e-04
## ASV8082     -1.072493e-04 -1.122170e-04 -1.174086e-04 -1.228335e-04
## ASV7696     -1.092262e-04 -1.142927e-04 -1.195882e-04 -1.251223e-04
## ASV0550      2.190446e-05  2.283888e-05  2.380869e-05  2.481490e-05
## ASV7745      1.397721e-04  1.464635e-04  1.534758e-04  1.608245e-04
## ASV3607     -3.061958e-06 -3.159568e-06 -3.257500e-06 -3.355402e-06
## ASV3877     -2.126277e-04 -2.222212e-04 -2.322236e-04 -2.426499e-04
## ASV7667     -9.692659e-05 -1.012405e-04 -1.057329e-04 -1.104103e-04
## ASV9293     -8.117553e-05 -8.498358e-05 -8.896685e-05 -9.313302e-05
## ASV11653    -2.125978e-04 -2.221886e-04 -2.321879e-04 -2.426110e-04
## ASV12850     3.407293e-05  3.583148e-05  3.768436e-05  3.963675e-05
## ASV13104     4.012899e-05  4.181829e-05  4.356779e-05  4.537856e-05
## ASV14208    -2.125845e-04 -2.221741e-04 -2.321721e-04 -2.425938e-04
## ASV1552      1.958015e-04  2.050952e-04  2.148273e-04  2.250182e-04
## ASV2501      1.329448e-04  1.388475e-04  1.449929e-04  1.513893e-04
## ASV2893      2.643546e-04  2.766160e-04  2.894296e-04  3.028187e-04
## ASV3084      1.002327e-04  1.047329e-04  1.094233e-04  1.143108e-04
## ASV3599      1.347227e-04  1.407350e-04  1.469968e-04  1.535168e-04
## ASV3868     -2.125852e-04 -2.221750e-04 -2.321731e-04 -2.425950e-04
## ASV3917     -2.862063e-04 -2.992136e-04 -3.127836e-04 -3.269382e-04
## ASV5695      5.349756e-05  5.609085e-05  5.881112e-05  6.166460e-05
## ASV0131      2.843974e-05  2.947963e-05  3.054157e-05  3.162437e-05
## ASV2847      2.578374e-04  2.693097e-04  2.812555e-04  2.936912e-04
## ASV6875     -2.123868e-04 -2.220704e-04 -2.321754e-04 -2.427184e-04
## ASV1547     -4.388431e-04 -4.586935e-04 -4.793935e-04 -5.009749e-04
## ASV1501     -2.759199e-04 -2.885504e-04 -3.017355e-04 -3.154977e-04
## ASV3876      3.073360e-04  3.214843e-04  3.362608e-04  3.516911e-04
## ASV3456     -3.073108e-04 -3.214568e-04 -3.362307e-04 -3.516581e-04
## ASV1194      2.897865e-04  3.031182e-04  3.170410e-04  3.315790e-04
## ASV2135     -3.710614e-04 -3.883227e-04 -4.063672e-04 -4.252287e-04
## ASV1352      3.072410e-04  3.213804e-04  3.361470e-04  3.515666e-04
## ASV3208      3.494944e-04  3.656004e-04  3.824229e-04  3.999916e-04
## ASV1164      2.816526e-06  3.077843e-06  3.362458e-06  3.672331e-06
## ASV3492      1.462533e-04  1.532737e-04  1.606327e-04  1.683465e-04
## ASV1601      1.690951e-04  1.768691e-04  1.849874e-04  1.934640e-04
## ASV5347     -2.169777e-04 -2.267651e-04 -2.369693e-04 -2.476059e-04
## ASV0293      1.632784e-04  1.708065e-04  1.786697e-04  1.868819e-04
## ASV1509      2.817382e-04  2.946789e-04  3.081909e-04  3.222972e-04
## ASV2801      4.099837e-05  4.283426e-05  4.474735e-05  4.674045e-05
## ASV2873     -6.531694e-05 -6.841826e-05 -7.166645e-05 -7.506843e-05
## ASV2162     -4.396592e-05 -4.594545e-05 -4.800903e-05 -5.015980e-05
## ASV0462      1.706805e-04  1.781254e-04  1.858649e-04  1.939081e-04
## ASV5367     -2.664213e-04 -2.788040e-04 -2.917471e-04 -3.052747e-04
## ASV2715      3.333161e-04  3.485021e-04  3.643479e-04  3.808792e-04
## ASV0371      4.092125e-04  4.274779e-04  4.465053e-04  4.663219e-04
## ASV8090     -2.823505e-04 -2.951448e-04 -3.084885e-04 -3.224026e-04
## ASV6320     -2.201712e-04 -2.304688e-04 -2.412392e-04 -2.525035e-04
## ASV2562      2.312476e-04  2.420903e-04  2.534329e-04  2.652975e-04
## ASV1505     -3.244115e-04 -3.395089e-04 -3.552912e-04 -3.717879e-04
## ASV4924     -2.488926e-04 -2.602586e-04 -2.721206e-04 -2.844980e-04
## ASV1437      2.780934e-04  2.908899e-04  3.042544e-04  3.182100e-04
## ASV3816     -1.859274e-05 -1.922965e-05 -1.987578e-05 -2.052993e-05
## ASV1969     -1.345179e-04 -1.410206e-04 -1.478370e-04 -1.549817e-04
## ASV3146      1.479452e-04  1.545320e-04  1.613910e-04  1.685318e-04
## ASV0321     -1.601262e-04 -1.673358e-04 -1.748520e-04 -1.826862e-04
## ASV1020      3.226165e-04  3.371940e-04  3.523946e-04  3.682417e-04
## ASV4138      2.247501e-05  2.365366e-05  2.489770e-05  2.621096e-05
## ASV0329     -1.784185e-04 -1.866798e-04 -1.953119e-04 -2.043300e-04
## ASV10647     3.204399e-05  3.359811e-05  3.522866e-05  3.693946e-05
## ASV3389      2.658415e-04  2.781051e-04  2.909155e-04  3.042953e-04
## ASV6880      1.433916e-04  1.495397e-04  1.559197e-04  1.625374e-04
## ASV2624     -3.567066e-05 -3.762129e-05 -3.968692e-05 -4.187487e-05
## ASV3686     -5.090753e-05 -5.385689e-05 -5.699237e-05 -6.032652e-05
## ASV12302    -2.215852e-04 -2.320153e-04 -2.429304e-04 -2.543525e-04
## ASV1184      2.715480e-04  2.839643e-04  2.969237e-04  3.104478e-04
## ASV3533     -1.164560e-04 -1.214891e-04 -1.267147e-04 -1.321379e-04
## ASV1735      6.485283e-05  6.763921e-05  7.053076e-05  7.353008e-05
## ASV0483     -1.257499e-04 -1.316715e-04 -1.378680e-04 -1.443516e-04
## ASV0928     -2.500426e-04 -2.616619e-04 -2.738075e-04 -2.865019e-04
## ASV12254    -2.194149e-04 -2.296380e-04 -2.403266e-04 -2.515010e-04
## ASV16025    -2.193967e-04 -2.296180e-04 -2.403048e-04 -2.514771e-04
## ASV3070     -2.193785e-04 -2.295981e-04 -2.402830e-04 -2.514532e-04
## ASV1850      5.154287e-05  5.403056e-05  5.663909e-05  5.937431e-05
## ASV8946     -2.154186e-04 -2.252622e-04 -2.355358e-04 -2.462565e-04
## ASV1536      1.806043e-04  1.888259e-04  1.974037e-04  2.063514e-04
## ASV4151      2.717614e-04  2.840690e-04  2.969049e-04  3.102890e-04
## ASV4585      3.649186e-04  3.814405e-04  3.986707e-04  4.166358e-04
## ASV4921     -8.827068e-05 -9.220630e-05 -9.630396e-05 -1.005690e-04
## ASV6172      2.153703e-04  2.252094e-04  2.354781e-04  2.461934e-04
## ASV6375     -2.153528e-04 -2.251902e-04 -2.354572e-04 -2.461706e-04
## ASV6501      2.450444e-04  2.559407e-04  2.672869e-04  2.790988e-04
## ASV17095    -2.153391e-04 -2.251753e-04 -2.354408e-04 -2.461527e-04
## ASV3679     -2.153216e-04 -2.251561e-04 -2.354199e-04 -2.461298e-04
## ASV5750      2.153041e-04  2.251370e-04  2.353990e-04  2.461069e-04
## ASV5922     -2.152866e-04 -2.251179e-04 -2.353781e-04 -2.460841e-04
## ASV7323     -2.152691e-04 -2.250987e-04 -2.353572e-04 -2.460612e-04
## ASV8515     -3.029757e-06 -3.208246e-06 -3.397529e-06 -3.598210e-06
## ASV8753     -2.152514e-04 -2.250794e-04 -2.353360e-04 -2.460381e-04
## ASV9197      1.479143e-04  1.547068e-04  1.617989e-04  1.692028e-04
## ASV1778      4.020945e-05  4.223005e-05  4.435610e-05  4.659336e-05
## ASV1241      2.777449e-04  2.903168e-04  3.034274e-04  3.170971e-04
## ASV1717      2.170687e-04  2.269942e-04  2.373546e-04  2.481671e-04
## ASV1112      2.492661e-04  2.603317e-04  2.718516e-04  2.838411e-04
## ASV3994      2.922535e-04  3.057686e-04  3.198885e-04  3.346382e-04
## ASV5511     -2.163460e-04 -2.262785e-04 -2.366494e-04 -2.474765e-04
## ASV8706      1.573124e-04  1.647663e-04  1.725708e-04  1.807424e-04
## ASV3049     -2.163318e-04 -2.262629e-04 -2.366323e-04 -2.474578e-04
## ASV4332      1.389872e-04  1.454961e-04  1.523039e-04  1.594237e-04
## ASV7411      2.452459e-04  2.562269e-04  2.676672e-04  2.795832e-04
## ASV7475     -2.163245e-04 -2.262549e-04 -2.366236e-04 -2.474483e-04
## ASV8988     -2.163068e-04 -2.262355e-04 -2.366024e-04 -2.474252e-04
## ASV0688     -4.619038e-04 -4.825900e-04 -5.041425e-04 -5.265922e-04
## ASV1946      1.247107e-04  1.301040e-04  1.357059e-04  1.415221e-04
## ASV3150      3.595062e-04  3.758225e-04  3.928415e-04  4.105900e-04
## ASV3508      1.756596e-04  1.834089e-04  1.914715e-04  1.998574e-04
## ASV3863     -2.162943e-04 -2.262218e-04 -2.365874e-04 -2.474087e-04
## ASV4544      1.699995e-04  1.774897e-04  1.852818e-04  1.933854e-04
## ASV4567      3.902525e-04  4.081109e-04  4.267526e-04  4.462088e-04
## ASV4855     -2.162759e-04 -2.262018e-04 -2.365655e-04 -2.473847e-04
## ASV4872      2.885060e-04  3.015479e-04  3.151465e-04  3.293228e-04
## ASV4881      2.078536e-04  2.176226e-04  2.278440e-04  2.385383e-04
## ASV5283      2.162615e-04  2.261860e-04  2.365482e-04  2.473659e-04
## ASV5302      2.554049e-04  2.670393e-04  2.791813e-04  2.918511e-04
## ASV5909      2.169794e-04  2.268944e-04  2.372425e-04  2.480408e-04
## ASV5933      1.619817e-04  1.694094e-04  1.771640e-04  1.852585e-04
## ASV6019      2.396653e-04  2.502446e-04  2.612532e-04  2.727050e-04
## ASV6043      9.635397e-05  1.009130e-04  1.056859e-04  1.106823e-04
## ASV6908      2.710760e-04  2.834683e-04  2.964027e-04  3.099006e-04
## ASV7245     -2.162711e-04 -2.261965e-04 -2.365597e-04 -2.473784e-04
## ASV7249     -2.162534e-04 -2.261772e-04 -2.365385e-04 -2.473552e-04
## ASV8349      7.288087e-05  7.628194e-05  7.983826e-05  8.355656e-05
## ASV7310     -2.162389e-04 -2.261613e-04 -2.365212e-04 -2.473363e-04
## ASV1893      1.676163e-04  1.752025e-04  1.831148e-04  1.913658e-04
## ASV2354      1.288137e-04  1.344019e-04  1.402082e-04  1.462391e-04
## ASV3435     -3.610447e-05 -3.763596e-05 -3.922346e-05 -4.086818e-05
## ASV0480      3.360087e-04  3.517316e-04  3.681749e-04  3.853700e-04
## ASV0955     -1.167153e-04 -1.221740e-04 -1.278834e-04 -1.338545e-04
## ASV10000     6.560541e-05  6.828848e-05  7.106013e-05  7.392131e-05
## ASV7215     -1.399114e-04 -1.464896e-04 -1.533721e-04 -1.605725e-04
## ASV10423    -3.061192e-04 -3.201521e-04 -3.348024e-04 -3.500949e-04
## ASV6008     -1.635480e-04 -1.710650e-04 -1.789144e-04 -1.871098e-04
## ASV9330     -3.060825e-04 -3.201120e-04 -3.347586e-04 -3.500469e-04
## ASV6051      3.060575e-04  3.200847e-04  3.347287e-04  3.500142e-04
## ASV1675      2.023236e-04  2.115853e-04  2.212532e-04  2.313435e-04
## ASV2043      1.312393e-04  1.374293e-04  1.439081e-04  1.506888e-04
## ASV3634      1.235159e-04  1.294583e-04  1.356888e-04  1.422217e-04
## ASV4077     -3.060455e-04 -3.200716e-04 -3.347144e-04 -3.499986e-04
## ASV4754      1.480862e-04  1.547842e-04  1.617686e-04  1.690504e-04
## ASV6095      3.510822e-04  3.668517e-04  3.832868e-04  4.004118e-04
## ASV6288      2.597196e-04  2.714681e-04  2.837190e-04  2.964910e-04
## ASV6507     -3.060302e-04 -3.200548e-04 -3.346961e-04 -3.499786e-04
## ASV8905      1.554055e-04  1.624326e-04  1.697606e-04  1.774006e-04
## ASV9728     -3.060095e-04 -3.200322e-04 -3.346713e-04 -3.499515e-04
## ASV11144    -3.059845e-04 -3.200049e-04 -3.346415e-04 -3.499189e-04
## ASV1615     -1.231216e-04 -1.288413e-04 -1.348195e-04 -1.410669e-04
## ASV2709     -3.732192e-04 -3.902793e-04 -4.080855e-04 -4.266671e-04
## ASV3003      2.960313e-04  3.097472e-04  3.240809e-04  3.390583e-04
## ASV5163     -2.820220e-04 -2.949297e-04 -3.084033e-04 -3.224652e-04
## ASV6622      1.981629e-04  2.074198e-04  2.171005e-04  2.272235e-04
## ASV1076     -2.921426e-04 -3.055900e-04 -3.196342e-04 -3.342998e-04
## ASV7895      6.917238e-05  7.221503e-05  7.537946e-05  7.866941e-05
## ASV10577    -2.214897e-04 -2.319113e-04 -2.428173e-04 -2.542296e-04
## ASV1272      2.214711e-04  2.318910e-04  2.427950e-04  2.542052e-04
## ASV2492     -1.095601e-04 -1.150851e-04 -1.209004e-04 -1.270222e-04
## ASV5195      2.660050e-04  2.782941e-04  2.911332e-04  3.045453e-04
## ASV5267      1.602000e-04  1.674419e-04  1.749926e-04  1.828637e-04
## ASV6317      2.264629e-04  2.370378e-04  2.480959e-04  2.596584e-04
## ASV2296      8.139850e-05  8.517411e-05  8.912081e-05  9.324603e-05
## ASV2290     -1.996027e-04 -2.085768e-04 -2.179301e-04 -2.276766e-04
## ASV3726      1.734843e-04  1.816807e-04  1.902607e-04  1.992417e-04
## ASV1169      1.467445e-04  1.534301e-04  1.604064e-04  1.676847e-04
## ASV0189     -1.405326e-04 -1.471923e-04 -1.541654e-04 -1.614665e-04
## ASV2729      5.319466e-04  5.568986e-04  5.830006e-04  6.103035e-04
## ASV3469      1.209760e-04  1.265955e-04  1.324694e-04  1.386085e-04
## ASV0762     -2.882260e-04 -3.011838e-04 -3.146886e-04 -3.287601e-04
## ASV9001     -2.666337e-04 -2.782655e-04 -2.903593e-04 -3.029297e-04
## ASV14604    -2.146222e-04 -2.243931e-04 -2.345877e-04 -2.452224e-04
## ASV7439      6.354142e-05  6.665689e-05  6.992867e-05  7.336486e-05
## ASV8625     -2.146078e-04 -2.243774e-04 -2.345706e-04 -2.452037e-04
## ASV11553     4.213573e-05  4.423132e-05  4.643465e-05  4.875152e-05
## ASV14440     5.436836e-06  5.345510e-06  5.219814e-06  5.055756e-06
## ASV16106    -2.145926e-04 -2.243608e-04 -2.345524e-04 -2.451838e-04
## ASV16110    -2.145752e-04 -2.243418e-04 -2.345316e-04 -2.451611e-04
## ASV2229      3.786603e-04  3.956060e-04  4.132606e-04  4.316492e-04
## ASV3854     -2.076622e-04 -2.171184e-04 -2.269848e-04 -2.372773e-04
## ASV5512     -2.145519e-04 -2.243162e-04 -2.345037e-04 -2.451305e-04
## ASV5939      2.881621e-04  3.013840e-04  3.151888e-04  3.295999e-04
## ASV6676     -1.483068e-04 -1.550614e-04 -1.621091e-04 -1.694612e-04
## ASV8381     -2.145127e-04 -2.242734e-04 -2.344568e-04 -2.450794e-04
## ASV2735      2.730752e-04  2.856658e-04  2.988167e-04  3.125508e-04
## ASV9816     -2.145010e-04 -2.242606e-04 -2.344429e-04 -2.450642e-04
## ASV1382      9.649822e-05  1.007420e-04  1.051567e-04  1.097478e-04
## ASV1408     -2.152873e-04 -2.251248e-04 -2.353926e-04 -2.461080e-04
## ASV4902      1.368931e-04  1.435233e-04  1.504786e-04  1.577752e-04
## ASV5600      1.664685e-04  1.740514e-04  1.819639e-04  1.902190e-04
## ASV0815     -4.654674e-05 -4.856547e-05 -5.066247e-05 -5.283992e-05
## ASV11867    -2.152784e-04 -2.251151e-04 -2.353821e-04 -2.460965e-04
## ASV16064    -2.152609e-04 -2.250960e-04 -2.353612e-04 -2.460736e-04
## ASV2250      2.704582e-04  2.829536e-04  2.960084e-04  3.096458e-04
## ASV2417      6.336086e-05  6.644068e-05  6.967215e-05  7.306284e-05
## ASV2807      3.513081e-04  3.669761e-04  3.832951e-04  4.002880e-04
## ASV3224     -2.152207e-04 -2.250520e-04 -2.353132e-04 -2.460213e-04
## ASV4115     -2.152032e-04 -2.250329e-04 -2.352923e-04 -2.459984e-04
## ASV4876      3.523454e-05  3.680328e-05  3.843616e-05  4.013520e-05
## ASV5291      2.094771e-04  2.189021e-04  2.287253e-04  2.389612e-04
## ASV5834      1.016242e-04  1.062727e-04  1.111245e-04  1.161876e-04
## ASV6896      2.363203e-05  2.462046e-05  2.564340e-05  2.670138e-05
## ASV7292     -2.151923e-04 -2.250209e-04 -2.352792e-04 -2.459841e-04
## ASV7924      1.237640e-04  1.295201e-04  1.355370e-04  1.418261e-04
## ASV0710      2.846017e-04  2.974813e-04  3.109120e-04  3.249144e-04
## ASV1925      2.477007e-04  2.588165e-04  2.703996e-04  2.824668e-04
## ASV4247     -2.151732e-04 -2.250002e-04 -2.352565e-04 -2.459593e-04
## ASV4549     -2.151557e-04 -2.249810e-04 -2.352356e-04 -2.459364e-04
## ASV4076      1.800996e-04  1.883409e-04  1.969442e-04  2.059239e-04
## ASV7063      1.749943e-04  1.830869e-04  1.915415e-04  2.003730e-04
## ASV1487      1.855140e-04  1.937493e-04  2.023227e-04  2.112457e-04
## ASV1405      7.709101e-05  8.078369e-05  8.465355e-05  8.870905e-05
## ASV3851      1.911600e-04  2.001324e-04  2.095183e-04  2.193360e-04
## ASV0896      5.830647e-05  6.100920e-05  6.383380e-05  6.678546e-05
## ASV5581      2.781426e-04  2.912655e-04  3.050011e-04  3.193775e-04
## ASV7053     -9.158270e-05 -9.579296e-05 -1.001898e-04 -1.047807e-04
## ASV7171     -2.198515e-04 -2.301175e-04 -2.408533e-04 -2.520796e-04
## ASV4017     -3.009519e-04 -3.149388e-04 -3.295594e-04 -3.448410e-04
## ASV5846      1.853635e-05  1.892617e-05  1.929185e-05  1.962881e-05
## ASV0203      1.870791e-06  1.812521e-06  1.741171e-06  1.655620e-06
## ASV13271     3.406787e-05  3.546091e-05  3.690003e-05  3.838571e-05
## ASV9487      1.375324e-04  1.433203e-04  1.493175e-04  1.555285e-04
## ASV2056     -3.083129e-04 -3.225771e-04 -3.374813e-04 -3.530522e-04
## ASV16933    -3.034104e-04 -3.172016e-04 -3.315897e-04 -3.465977e-04
## ASV0360      1.317491e-04  1.375842e-04  1.436585e-04  1.499802e-04
## ASV1798     -1.973238e-04 -2.062861e-04 -2.156355e-04 -2.253867e-04
## ASV17286    -2.196155e-04 -2.298569e-04 -2.405655e-04 -2.517616e-04
## ASV8175     -2.195973e-04 -2.298370e-04 -2.405437e-04 -2.517377e-04
## ASV6679      2.324195e-04  2.429851e-04  2.540073e-04  2.655036e-04
## ASV6776      1.121038e-04  1.170892e-04  1.222798e-04  1.276825e-04
## ASV9062     -2.195807e-04 -2.298189e-04 -2.405238e-04 -2.517160e-04
## ASV9564     -1.948819e-05 -2.050722e-05 -2.158318e-05 -2.271953e-05
## ASV6431     -2.195612e-04 -2.297974e-04 -2.405003e-04 -2.516902e-04
## ASV9940      8.953010e-05  9.360229e-05  9.785030e-05  1.022808e-04
## ASV7001     -3.038506e-04 -3.176744e-04 -3.320969e-04 -3.471412e-04
## ASV3044      3.431141e-04  3.587228e-04  3.750080e-04  3.919963e-04
## ASV6684      1.269279e-04  1.330349e-04  1.394376e-04  1.461504e-04
## ASV12278     2.020225e-06  2.206052e-06  2.408435e-06  2.628775e-06
## ASV3543     -2.029955e-04 -2.119291e-04 -2.212237e-04 -2.308910e-04
## ASV6397      2.016583e-06  2.202065e-06  2.404071e-06  2.623999e-06
## ASV9939      2.016266e-06  2.201703e-06  2.403658e-06  2.623528e-06
## ASV9432      1.773326e-04  1.857141e-04  1.944881e-04  2.036724e-04
## ASV2630     -2.205144e-04 -2.308506e-04 -2.416629e-04 -2.529724e-04
## ASV2175      2.894555e-04  3.030411e-04  3.172547e-04  3.321245e-04
## ASV4107      2.386574e-04  2.497489e-04  2.613426e-04  2.734598e-04
## ASV9172     -3.042577e-05 -3.200334e-05 -3.366776e-05 -3.542421e-05
## ASV3141      2.840726e-04  2.974792e-04  3.115122e-04  3.262003e-04
## ASV9010     -2.201479e-04 -2.304406e-04 -2.412054e-04 -2.524631e-04
## ASV2550      2.180251e-04  2.280265e-04  2.384686e-04  2.493691e-04
## ASV5845     -2.201354e-04 -2.304269e-04 -2.411903e-04 -2.524465e-04
## ASV3998      2.201171e-04  2.304068e-04  2.411684e-04  2.524225e-04
## ASV1389     -2.373311e-04 -2.476475e-04 -2.583698e-04 -2.695105e-04
## ASV0615     -2.484669e-04 -2.598675e-04 -2.717713e-04 -2.841988e-04
## ASV9127     -3.045625e-04 -3.184917e-04 -3.330310e-04 -3.482047e-04
## ASV1190      4.329422e-04  4.523464e-04  4.725647e-04  4.936264e-04
## ASV1211      1.091160e-04  1.141086e-04  1.193210e-04  1.247621e-04
## ASV1766     -3.131966e-04 -3.276179e-04 -3.426796e-04 -3.584079e-04
## ASV2337      2.180333e-04  2.281206e-04  2.386601e-04  2.496707e-04
## ASV2463      4.694385e-05  4.911359e-05  5.138028e-05  5.374792e-05
## ASV2806      1.626634e-04  1.699351e-04  1.775120e-04  1.854052e-04
## ASV0439     -2.807955e-04 -2.937222e-04 -3.072224e-04 -3.213196e-04
## ASV0839      2.675680e-04  2.801947e-04  2.934101e-04  3.072408e-04
## ASV14975    -2.180016e-04 -2.280858e-04 -2.386220e-04 -2.496290e-04
## ASV17712    -2.179836e-04 -2.280662e-04 -2.386005e-04 -2.496055e-04
## ASV2010     -2.480247e-05 -2.589144e-05 -2.702342e-05 -2.819964e-05
## ASV2041      1.142353e-04  1.197560e-04  1.255455e-04  1.316170e-04
## ASV2124     -2.812440e-04 -2.942906e-04 -3.079256e-04 -3.221737e-04
## ASV2585      3.891746e-04  4.070408e-04  4.256951e-04  4.451696e-04
## ASV3314      3.080873e-04  3.224654e-04  3.375002e-04  3.532206e-04
## ASV5051     -2.837866e-05 -2.952206e-05 -3.070038e-05 -3.191350e-05
## ASV10784     1.093667e-04  1.143452e-04  1.195397e-04  1.249587e-04
## ASV3279     -2.179403e-04 -2.280187e-04 -2.385486e-04 -2.495487e-04
## ASV9498      1.512735e-05  1.569238e-05  1.627064e-05  1.686162e-05
## ASV1059     -2.325915e-04 -2.435014e-04 -2.549149e-04 -2.668545e-04
## ASV13008    -2.179219e-04 -2.279986e-04 -2.385265e-04 -2.495245e-04
## ASV15803    -2.179039e-04 -2.279789e-04 -2.385050e-04 -2.495010e-04
## ASV2559     -2.114945e-04 -2.212817e-04 -2.315082e-04 -2.421923e-04
## ASV2623     -2.178865e-04 -2.279598e-04 -2.384841e-04 -2.494781e-04
## ASV2802     -1.224668e-04 -1.280608e-04 -1.338991e-04 -1.399916e-04
## ASV3799      3.346632e-04  3.499627e-04  3.659319e-04  3.825976e-04
## ASV5274     -3.861119e-07 -5.197016e-07 -6.697946e-07 -8.380166e-07
## ASV5835      1.344055e-04  1.407495e-04  1.473905e-04  1.543423e-04
## ASV7251     -2.178824e-04 -2.279553e-04 -2.384792e-04 -2.494727e-04
## ASV7616     -2.178645e-04 -2.279357e-04 -2.384577e-04 -2.494492e-04
## ASV9576     -2.178465e-04 -2.279161e-04 -2.384362e-04 -2.494257e-04
## ASV2870      1.596508e-04  1.670462e-04  1.747738e-04  1.828476e-04
## ASV3668     -1.403372e-04 -1.469044e-04 -1.537727e-04 -1.609554e-04
## ASV1633      1.061562e-04  1.111720e-04  1.164225e-04  1.219184e-04
## ASV6060     -4.242554e-06 -4.802858e-06 -5.420161e-06 -6.099509e-06
## ASV6305      1.097325e-04  1.148994e-04  1.203064e-04  1.259644e-04
## ASV5164      7.122610e-05  7.432736e-05  7.754981e-05  8.089688e-05
## ASV7252     -2.183428e-04 -2.284635e-04 -2.390401e-04 -2.500919e-04
## ASV9343      1.882788e-04  1.972543e-04  2.066574e-04  2.165084e-04
## ASV6835     -3.650751e-05 -3.814515e-05 -3.985153e-05 -4.162908e-05
## ASV1264      2.658255e-04  2.780000e-04  2.907101e-04  3.039772e-04
## ASV0591      2.337366e-05  2.411149e-05  2.485172e-05  2.559179e-05
## ASV1351      3.070664e-04  3.213135e-04  3.362034e-04  3.517637e-04
## ASV14224    -2.182984e-04 -2.284149e-04 -2.389869e-04 -2.500337e-04
## ASV1432     -2.182804e-04 -2.283952e-04 -2.389654e-04 -2.500101e-04
## ASV1559     -1.829324e-04 -1.914743e-04 -2.004066e-04 -2.097464e-04
## ASV2182      3.390168e-04  3.545321e-04  3.707281e-04  3.876318e-04
## ASV2304     -1.818293e-05 -1.896542e-05 -1.977759e-05 -2.062017e-05
## ASV6838     -1.874373e-06 -1.943827e-06 -2.014863e-06 -2.087417e-06
## ASV1125     -3.272394e-05 -3.431070e-05 -3.597539e-05 -3.772191e-05
## ASV17948    -2.182739e-04 -2.283880e-04 -2.389575e-04 -2.500015e-04
## ASV2609      1.925371e-04  2.015487e-04  2.109743e-04  2.208322e-04
## ASV6128     -1.790450e-04 -1.873894e-04 -1.961100e-04 -2.052221e-04
## ASV1338      4.307877e-05  4.476483e-05  4.649873e-05  4.828003e-05
## ASV2136      7.923055e-05  8.268808e-05  8.628219e-05  9.001703e-05
## ASV0929     -1.992268e-04 -2.083065e-04 -2.177815e-04 -2.276673e-04
## ASV3479      1.374176e-04  1.435905e-04  1.500232e-04  1.567250e-04
## ASV0886      3.667310e-04  3.836225e-04  4.012646e-04  4.196881e-04
## ASV1652      1.683834e-04  1.762041e-04  1.843787e-04  1.929226e-04
## ASV1160      3.043260e-04  3.184318e-04  3.331730e-04  3.485764e-04
## ASV5260     -5.755526e-05 -6.043503e-05 -6.346356e-05 -6.664881e-05
## ASV2352      3.732904e-04  3.899370e-04  4.072755e-04  4.253304e-04
## ASV0986     -1.480595e-04 -1.547455e-04 -1.617169e-04 -1.689844e-04
## ASV2021      2.456261e-04  2.568582e-04  2.685823e-04  2.808180e-04
## ASV16599    -2.014503e-04 -2.112867e-04 -2.216090e-04 -2.324412e-04
## ASV3497      1.867079e-04  1.954139e-04  2.045174e-04  2.140358e-04
## ASV1305      1.256721e-04  1.317357e-04  1.380927e-04  1.447569e-04
## ASV0927     -2.863010e-04 -2.986450e-04 -3.114620e-04 -3.247652e-04
## ASV0647     -9.417666e-05 -9.810533e-05 -1.021715e-04 -1.063775e-04
## ASV1832     -1.220917e-04 -1.276389e-04 -1.334260e-04 -1.394623e-04
## ASV1277      1.454371e-04  1.520976e-04  1.590507e-04  1.663078e-04
## ASV22332    -2.187946e-04 -2.289576e-04 -2.395805e-04 -2.506828e-04
## ASV10080    -2.759264e-05 -2.932664e-05 -3.117883e-05 -3.315757e-05
## ASV14157     2.941869e-05  3.086035e-05  3.237419e-05  3.396394e-05
## ASV15829    -2.187759e-04 -2.289371e-04 -2.395580e-04 -2.506581e-04
## ASV3609     -2.187578e-04 -2.289173e-04 -2.395363e-04 -2.506343e-04
## ASV5737      4.862428e-05  5.069145e-05  5.283440e-05  5.505473e-05
## ASV1474      1.595729e-04  1.670278e-04  1.748230e-04  1.829734e-04
## ASV2028      2.177712e-04  2.271623e-04  2.369136e-04  2.470349e-04
## ASV0818      2.629295e-04  2.750375e-04  2.876831e-04  3.008884e-04
## ASV0505     -2.275919e-04 -2.382151e-04 -2.493225e-04 -2.609350e-04
## ASV1813      1.072531e-04  1.119624e-04  1.168599e-04  1.219515e-04
## ASV0512      2.364287e-04  2.476362e-04  2.593678e-04  2.716470e-04
## ASV5374     -1.673890e-04 -1.751582e-04 -1.832791e-04 -1.917670e-04
## ASV2927     -2.137604e-05 -2.197142e-05 -2.255701e-05 -2.312906e-05
## ASV3596      1.641129e-04  1.714125e-04  1.790128e-04  1.869240e-04
## ASV1137      9.795614e-05  1.022386e-04  1.066897e-04  1.113144e-04
## ASV4541      2.491424e-06  2.722248e-06  2.973869e-06  3.248077e-06
## ASV9872     -2.491030e-06 -2.721798e-06 -2.973355e-06 -3.247491e-06
## ASV0359     -7.685836e-05 -8.025237e-05 -8.378382e-05 -8.745713e-05
## ASV0720     -1.312428e-04 -1.371071e-04 -1.432150e-04 -1.495752e-04
## ASV10545    -2.501567e-06 -2.733273e-06 -2.985846e-06 -3.261082e-06
## ASV13384    -2.501172e-06 -2.732821e-06 -2.985330e-06 -3.260493e-06
## ASV1456      5.722253e-06  5.964343e-06  6.215310e-06  6.475361e-06
## ASV1751     -2.501050e-06 -2.732667e-06 -2.985138e-06 -3.260255e-06
## ASV18419    -2.500655e-06 -2.732216e-06 -2.984622e-06 -3.259667e-06
## ASV2970      2.500260e-06  2.731764e-06  2.984107e-06  3.259078e-06
## ASV4215      1.707680e-04  1.786233e-04  1.868264e-04  1.953916e-04
## ASV4742      2.838079e-05  2.950378e-05  3.066007e-05  3.184958e-05
## ASV5017      5.383657e-05  5.621939e-05  5.869929e-05  6.127948e-05
## ASV5139     -2.497359e-06 -2.728528e-06 -2.980495e-06 -3.255047e-06
## ASV9133     -2.496965e-06 -2.728078e-06 -2.979980e-06 -3.254459e-06
## ASV9447     -2.496570e-06 -2.727627e-06 -2.979466e-06 -3.253872e-06
## ASV0842     -1.621757e-04 -1.691868e-04 -1.764693e-04 -1.840311e-04
## ASV12293     1.136274e-04  1.184250e-04  1.233973e-04  1.285482e-04
## ASV1965      2.053506e-04  2.149213e-04  2.249283e-04  2.353904e-04
## ASV2005      2.243758e-04  2.340999e-04  2.442016e-04  2.546918e-04
## ASV5335      1.670261e-04  1.743746e-04  1.820184e-04  1.899668e-04
## ASV6438     -2.522504e-06 -2.755874e-06 -3.010222e-06 -3.287348e-06
## ASV7798     -2.522106e-06 -2.755419e-06 -3.009702e-06 -3.286755e-06
## ASV2691     -2.311759e-04 -2.419086e-04 -2.531257e-04 -2.648478e-04
## ASV9958      1.890201e-04  1.975922e-04  2.065329e-04  2.158565e-04
## ASV1512      6.866250e-05  7.194275e-05  7.538027e-05  7.898267e-05
## ASV1226      3.104388e-04  3.246570e-04  3.395005e-04  3.549946e-04
## ASV2130     -5.476751e-04 -5.727315e-04 -5.988865e-04 -6.261838e-04
## ASV0874     -1.704468e-04 -1.782046e-04 -1.863006e-04 -1.947482e-04
## ASV5436     -2.437531e-04 -2.550209e-04 -2.667929e-04 -2.790900e-04
## ASV0383     -2.687252e-04 -2.805007e-04 -2.927453e-04 -3.054738e-04
## ASV1882      2.628096e-04  2.743416e-04  2.863364e-04  2.988090e-04
## ASV2471     -1.484745e-04 -1.552566e-04 -1.623351e-04 -1.697219e-04
## ASV4049     -2.109240e-04 -2.205115e-04 -2.305135e-04 -2.409458e-04
## ASV3014     -1.181075e-04 -1.233433e-04 -1.287933e-04 -1.344648e-04
## ASV0316     -4.226124e-04 -4.419611e-04 -4.621594e-04 -4.832412e-04
## ASV1621     -2.931967e-04 -3.064334e-04 -3.202345e-04 -3.346212e-04
## ASV13266    -2.152050e-04 -2.250324e-04 -2.352889e-04 -2.459915e-04
## ASV1635     -2.133967e-04 -2.231386e-04 -2.333057e-04 -2.439146e-04
## ASV2042      1.567492e-04  1.639156e-04  1.713960e-04  1.792027e-04
## ASV2317     -2.557863e-04 -2.674248e-04 -2.795676e-04 -2.922343e-04
## ASV3697      1.933247e-04  2.020078e-04  2.110570e-04  2.204858e-04
## ASV6404      3.557320e-04  3.716276e-04  3.881872e-04  4.054344e-04
## ASV15616     1.471149e-05  1.554546e-05  1.643093e-05  1.737135e-05
## ASV10783    -2.151676e-04 -2.249915e-04 -2.352442e-04 -2.459426e-04
## ASV6912     -1.614545e-04 -1.687783e-04 -1.764171e-04 -1.843832e-04
## ASV1561      4.364048e-04  4.560003e-04  4.764220e-04  4.976999e-04
## ASV4404      2.974455e-04  3.109944e-04  3.251319e-04  3.398811e-04
## ASV1110      2.184453e-04  2.283126e-04  2.386008e-04  2.493255e-04
## ASV2844     -7.392366e-05 -7.746319e-05 -8.117248e-05 -8.505965e-05
## ASV5224      2.180135e-04  2.279386e-04  2.382938e-04  2.490957e-04
## ASV6300     -2.185094e-04 -2.286450e-04 -2.392377e-04 -2.503069e-04
## ASV8078     -2.184914e-04 -2.286252e-04 -2.392160e-04 -2.502832e-04
## ASV9722      1.015510e-06  8.513735e-07  6.604026e-07  4.397029e-07
## ASV6911     -2.184732e-04 -2.286053e-04 -2.391942e-04 -2.502592e-04
## ASV5474     -4.471748e-05 -4.687674e-05 -4.914118e-05 -5.151595e-05
## ASV2761     -5.123231e-04 -5.356537e-04 -5.599972e-04 -5.853929e-04
## ASV5943     -1.423322e-04 -1.491705e-04 -1.563394e-04 -1.638552e-04
## ASV0600     -3.729299e-05 -3.863422e-05 -4.000127e-05 -4.139225e-05
## ASV0608     -4.596956e-04 -4.805294e-04 -5.022594e-04 -5.249199e-04
## ASV1586      1.107765e-04  1.156770e-04  1.207779e-04  1.260860e-04
## ASV0206     -5.107018e-04 -5.334371e-04 -5.571121e-04 -5.817589e-04
## ASV4042     -2.338344e-04 -2.445300e-04 -2.556942e-04 -2.673457e-04
## ASV5304     -6.956317e-06 -7.333134e-06 -7.731340e-06 -8.152156e-06
## ASV0949     -8.113769e-05 -8.534301e-05 -8.977759e-05 -9.445458e-05
## ASV1856      2.693416e-04  2.816855e-04  2.945722e-04  3.080233e-04
## ASV2584      3.183467e-05  3.317314e-05  3.455842e-05  3.599114e-05
## ASV2287     -1.329848e-05 -1.427720e-05 -1.533065e-05 -1.646441e-05
## ASV2364     -3.822223e-04 -3.996122e-04 -4.177560e-04 -4.366831e-04
## ASV11481    -3.045333e-04 -3.188037e-04 -3.337312e-04 -3.493449e-04
## ASV2906     -1.059508e-04 -1.109428e-04 -1.161668e-04 -1.216333e-04
## ASV0161     -1.267269e-04 -1.324835e-04 -1.384884e-04 -1.447511e-04
## ASV0062     -8.328797e-04 -8.707823e-04 -9.103279e-04 -9.515801e-04
## ASV3811     -1.969001e-04 -2.052718e-04 -2.139562e-04 -2.229616e-04
## ASV0225      3.295846e-05  3.414475e-05  3.535521e-05  3.658853e-05
## ASV4672     -2.670309e-04 -2.790297e-04 -2.915350e-04 -3.045655e-04
## ASV1607     -2.032511e-05 -2.129849e-05 -2.231709e-05 -2.338276e-05
## ASV3060      5.275905e-05  5.530193e-05  5.796848e-05  6.076477e-05
## ASV2275     -3.811152e-05 -3.985348e-05 -4.167156e-05 -4.356873e-05
## ASV5375      1.491433e-04  1.561714e-04  1.635268e-04  1.712244e-04
## ASV0352     -4.458897e-04 -4.666092e-04 -4.882668e-04 -5.109025e-04
## ASV1107      1.284986e-04  1.346258e-04  1.410429e-04  1.477633e-04
## ASV4887      1.160149e-04  1.210480e-04  1.262766e-04  1.317062e-04
## ASV2397     -5.852251e-05 -6.093993e-05 -6.343947e-05 -6.602225e-05
## ASV7541     -1.399072e-04 -1.462362e-04 -1.528357e-04 -1.597159e-04
## ASV7387     -3.059791e-04 -3.200121e-04 -3.346628e-04 -3.499560e-04
## ASV1355      2.805798e-04  2.935556e-04  3.071138e-04  3.212789e-04
## ASV1764     -1.463750e-04 -1.530030e-04 -1.599156e-04 -1.671236e-04
## ASV1960     -2.694491e-04 -2.810067e-04 -2.930044e-04 -3.054541e-04
## ASV0484     -5.172640e-05 -5.409339e-05 -5.656442e-05 -5.914368e-05
## ASV2487      8.370591e-05  8.717208e-05  9.075751e-05  9.446409e-05
## ASV0422      2.618547e-04  2.732450e-04  2.850843e-04  2.973864e-04
## ASV0081     -1.637787e-04 -1.715348e-04 -1.796557e-04 -1.881583e-04
## ASV1341     -1.413523e-04 -1.475339e-04 -1.539606e-04 -1.606400e-04
## ASV1001     -3.345058e-04 -3.492267e-04 -3.645402e-04 -3.804652e-04
## ASV0317     -8.091936e-05 -8.484415e-05 -8.895954e-05 -9.327457e-05
## ASV2728     -2.322615e-04 -2.428819e-04 -2.539676e-04 -2.655374e-04
## ASV0884     -2.979099e-04 -3.121335e-04 -3.270351e-04 -3.426469e-04
## ASV0464      6.378469e-05  6.721782e-05  7.084906e-05  7.469066e-05
## ASV2963      2.033931e-04  2.125073e-04  2.220048e-04  2.318994e-04
## ASV4608      9.187654e-05  9.607203e-05  1.004505e-04  1.050190e-04
## ASV3534      2.280629e-04  2.379087e-04  2.481331e-04  2.587465e-04
## ASV0291     -1.963962e-04 -2.052262e-04 -2.144288e-04 -2.240175e-04
## ASV0635     -2.833483e-04 -2.965828e-04 -3.104230e-04 -3.248955e-04
## ASV0867      2.281087e-04  2.389338e-04  2.502698e-04  2.621408e-04
## ASV1206     -2.647460e-05 -2.756754e-05 -2.869728e-05 -2.986425e-05
## ASV1230     -1.652324e-06 -1.808350e-06 -1.978836e-06 -2.165083e-06
## ASV1265      6.070155e-05  6.347452e-05  6.636886e-05  6.938943e-05
## ASV1291     -1.874112e-04 -1.961785e-04 -2.053481e-04 -2.149377e-04
## ASV1524      3.866199e-04  4.037853e-04  4.216560e-04  4.402559e-04
## ASV2153     -2.982921e-04 -3.115402e-04 -3.253340e-04 -3.396925e-04
## ASV2714      1.626562e-06  1.780256e-06  1.948209e-06  2.131702e-06
## ASV4246     -1.626300e-06 -1.779957e-06 -1.947866e-06 -2.131309e-06
## ASV0945      1.986507e-04  2.077273e-04  2.172003e-04  2.270853e-04
## ASV2380      4.614023e-04  4.819285e-04  5.033032e-04  5.255556e-04
## ASV0214     -6.920130e-05 -7.180585e-05 -7.447479e-05 -7.720645e-05
## ASV10461    -1.654166e-06 -1.810403e-06 -1.981126e-06 -2.167636e-06
## ASV4177      1.349456e-04  1.407200e-04  1.467115e-04  1.529256e-04
## ASV0237     -3.341642e-04 -3.497075e-04 -3.659555e-04 -3.829385e-04
## ASV11323    -3.774228e-04 -3.948444e-04 -4.130445e-04 -4.320556e-04
## ASV2232     -6.516298e-05 -6.802980e-05 -7.101182e-05 -7.411267e-05
## ASV0115     -1.216454e-04 -1.272114e-04 -1.330209e-04 -1.390834e-04
## ASV1171      5.650526e-05  5.875872e-05  6.108116e-05  6.347272e-05
## ASV1942      2.614545e-04  2.735326e-04  2.861516e-04  2.993341e-04
## ASV1889      2.619466e-05  2.733046e-05  2.851004e-05  2.973458e-05
## ASV0920      5.805068e-05  6.085058e-05  6.378649e-05  6.686501e-05
## ASV1805     -3.351709e-04 -3.504689e-04 -3.664345e-04 -3.830940e-04
## ASV1712      2.007825e-04  2.097931e-04  2.191818e-04  2.289622e-04
## ASV1458      2.949781e-04  3.080727e-04  3.217072e-04  3.359001e-04
## ASV1985      3.134572e-04  3.276648e-04  3.424841e-04  3.579385e-04
## ASV2960     -2.002722e-04 -2.087584e-04 -2.175588e-04 -2.266814e-04
## ASV5207     -6.093747e-05 -6.313201e-05 -6.537223e-05 -6.765590e-05
## ASV8548     -2.002538e-04 -2.087384e-04 -2.175372e-04 -2.266580e-04
## ASV0449     -1.200702e-04 -1.258108e-04 -1.318229e-04 -1.381188e-04
## ASV0609     -2.709821e-04 -2.832046e-04 -2.959462e-04 -3.092258e-04
## ASV1038      1.041186e-04  1.085141e-04  1.130689e-04  1.177865e-04
## ASV1145     -6.278539e-05 -6.535557e-05 -6.801173e-05 -7.075504e-05
## ASV15767    -2.002500e-04 -2.087344e-04 -2.175330e-04 -2.266535e-04
## ASV1630      2.824176e-04  2.948103e-04  3.077013e-04  3.211072e-04
## ASV1911      3.521629e-04  3.683250e-04  3.852004e-04  4.028181e-04
## ASV1950      2.546571e-04  2.657085e-04  2.771936e-04  2.891257e-04
## ASV2583      2.001975e-04  2.086773e-04  2.174709e-04  2.265860e-04
## ASV2853     -2.938241e-04 -3.068009e-04 -3.203066e-04 -3.343591e-04
## ASV2948      2.001662e-04  2.086432e-04  2.174338e-04  2.265457e-04
## ASV3116     -3.203038e-04 -3.342644e-04 -3.487773e-04 -3.638595e-04
## ASV3160     -1.721344e-04 -1.793088e-04 -1.867377e-04 -1.944265e-04
## ASV3354      2.117336e-04  2.214887e-04  2.316762e-04  2.423134e-04
## ASV3368      2.001230e-04  2.085963e-04  2.173829e-04  2.264905e-04
## ASV3464     -2.001079e-04 -2.085800e-04 -2.173652e-04 -2.264713e-04
## ASV3577      2.000929e-04  2.085637e-04  2.173475e-04  2.264521e-04
## ASV3746      2.618458e-04  2.731923e-04  2.849809e-04  2.972243e-04
## ASV3942      8.648225e-05  9.083721e-05  9.541863e-05  1.002386e-04
## ASV4000      2.000680e-04  2.085366e-04  2.173181e-04  2.264203e-04
## ASV4207      3.579170e-04  3.746604e-04  3.921716e-04  4.104844e-04
## ASV4261      2.000549e-04  2.085224e-04  2.173028e-04  2.264037e-04
## ASV4466      7.308501e-05  7.700582e-05  8.114786e-05  8.552393e-05
## ASV4487     -2.000448e-04 -2.085115e-04 -2.172910e-04 -2.263910e-04
## ASV4572     -1.514157e-04 -1.579625e-04 -1.647646e-04 -1.718295e-04
## ASV4718      2.000199e-04  2.084845e-04  2.172616e-04  2.263591e-04
## ASV4757     -2.000048e-04 -2.084682e-04 -2.172439e-04 -2.263399e-04
## ASV4929     -1.999898e-04 -2.084518e-04 -2.172262e-04 -2.263208e-04
## ASV5611     -1.999748e-04 -2.084355e-04 -2.172085e-04 -2.263016e-04
## ASV5614     -1.999598e-04 -2.084192e-04 -2.171909e-04 -2.262824e-04
## ASV5898      1.732545e-04  1.809760e-04  1.890172e-04  1.973891e-04
## ASV7627     -4.356172e-05 -4.498595e-05 -4.642429e-05 -4.787347e-05
## ASV3105     -1.099555e-04 -1.144484e-04 -1.190931e-04 -1.238922e-04
## ASV4762     -2.938815e-04 -3.068702e-04 -3.203893e-04 -3.344568e-04
## ASV5622      1.999216e-04  2.083778e-04  2.171459e-04  2.262337e-04
## ASV7129      2.601626e-04  2.718741e-04  2.840824e-04  2.968057e-04
## ASV12138    -1.999011e-04 -2.083555e-04 -2.171217e-04 -2.262074e-04
## ASV1687     -2.982200e-04 -3.116393e-04 -3.256298e-04 -3.402132e-04
## ASV2187      1.483578e-04  1.545662e-04  1.609977e-04  1.676573e-04
## ASV2204      3.019566e-04  3.154713e-04  3.295509e-04  3.442155e-04
## ASV2914      2.338801e-04  2.439220e-04  2.543482e-04  2.651693e-04
## ASV3297     -1.998466e-04 -2.082962e-04 -2.170573e-04 -2.261374e-04
## ASV3310     -2.566417e-04 -2.677659e-04 -2.793253e-04 -2.913329e-04
## ASV3677      1.504764e-05  1.632678e-05  1.771226e-05  1.921234e-05
## ASV4508      1.998143e-04  2.082613e-04  2.170194e-04  2.260963e-04
## ASV6236     -9.720674e-05 -1.009583e-04 -1.048152e-04 -1.087768e-04
## ASV6285      1.997932e-04  2.082383e-04  2.169946e-04  2.260695e-04
## ASV7576     -1.997782e-04 -2.082221e-04 -2.169769e-04 -2.260503e-04
## ASV7917     -1.997632e-04 -2.082058e-04 -2.169593e-04 -2.260312e-04
## ASV9353     -1.997482e-04 -2.081896e-04 -2.169416e-04 -2.260121e-04
## ASV1656      3.310690e-04  3.457951e-04  3.611298e-04  3.770942e-04
## ASV0280     -3.145760e-04 -3.292991e-04 -3.446987e-04 -3.608048e-04
## ASV4747      5.383847e-06  5.897856e-06  6.459893e-06  7.074312e-06
## ASV2108     -3.858263e-04 -4.037599e-04 -4.225066e-04 -4.421015e-04
## ASV0885      1.293817e-04  1.353426e-04  1.415689e-04  1.480715e-04
## ASV2538     -1.051119e-04 -1.097742e-04 -1.146274e-04 -1.196779e-04
## ASV0968      2.383856e-04  2.492193e-04  2.605210e-04  2.723089e-04
## ASV1229     -2.141683e-04 -2.238943e-04 -2.340396e-04 -2.446201e-04
## ASV13306    -2.141510e-04 -2.238754e-04 -2.340189e-04 -2.445975e-04
## ASV13952     1.309652e-04  1.366343e-04  1.425231e-04  1.486379e-04
## ASV14631     1.188727e-04  1.247064e-04  1.308336e-04  1.372695e-04
## ASV2119      2.533456e-04  2.643056e-04  2.756895e-04  2.875093e-04
## ASV2450      2.230655e-04  2.333469e-04  2.440865e-04  2.553031e-04
## ASV2656     -2.141441e-04 -2.238680e-04 -2.340108e-04 -2.445887e-04
## ASV2942     -1.554458e-05 -1.621667e-05 -1.691439e-05 -1.763839e-05
## ASV3302      1.910413e-04  1.996138e-04  2.085463e-04  2.178516e-04
## ASV6515      7.377221e-05  7.683090e-05  7.999558e-05  8.326806e-05
## ASV6674     -2.141300e-04 -2.238525e-04 -2.339939e-04 -2.445702e-04
## ASV7296     -7.930468e-05 -8.300960e-05 -8.688357e-05 -9.093387e-05
## ASV7903      1.176547e-04  1.227839e-04  1.281157e-04  1.336563e-04
## ASV7943     -2.141120e-04 -2.238328e-04 -2.339723e-04 -2.445466e-04
## ASV8864      1.578085e-04  1.643352e-04  1.710862e-04  1.780653e-04
## ASV9389      2.023261e-05  2.071273e-05  2.117451e-05  2.161387e-05
## ASV9869     -2.141000e-04 -2.238196e-04 -2.339578e-04 -2.445306e-04
## ASV1051      2.140827e-04  2.238007e-04  2.339372e-04  2.445081e-04
## ASV13035    -9.455675e-06 -9.817909e-06 -1.018946e-05 -1.057008e-05
## ASV15744     5.693780e-06  6.268183e-06  6.897489e-06  7.586712e-06
## ASV2526      2.268316e-05  2.352233e-05  2.438097e-05  2.525841e-05
## ASV1156      1.120679e-04  1.170929e-04  1.223289e-04  1.277838e-04
## ASV13562    -2.140728e-04 -2.237899e-04 -2.339254e-04 -2.444953e-04
## ASV1438      1.872198e-04  1.959524e-04  2.050843e-04  2.146329e-04
## ASV2268     -2.140639e-04 -2.237802e-04 -2.339149e-04 -2.444838e-04
## ASV2797      1.027806e-04  1.076849e-04  1.128234e-04  1.182072e-04
## ASV3744      2.385628e-04  2.495946e-04  2.611201e-04  2.731597e-04
## ASV8076     -2.306527e-04 -2.411392e-04 -2.520788e-04 -2.634888e-04
## ASV7055      9.891845e-05  1.037535e-04  1.088295e-04  1.141590e-04
## ASV7493     -1.954691e-04 -2.044099e-04 -2.137424e-04 -2.234820e-04
## ASV1201      4.757234e-04  4.972677e-04  5.197364e-04  5.431645e-04
## ASV5736     -4.115221e-04 -4.304951e-04 -4.503129e-04 -4.710104e-04
## ASV0558      1.990946e-04  2.084215e-04  2.181766e-04  2.283788e-04
## ASV14399    -2.852307e-04 -2.981269e-04 -3.115747e-04 -3.255949e-04
## ASV2992     -1.613504e-05 -1.685122e-05 -1.759672e-05 -1.837254e-05
## ASV4303     -2.095209e-04 -2.190279e-04 -2.289440e-04 -2.392847e-04
## ASV0565     -2.385789e-04 -2.494992e-04 -2.608998e-04 -2.727999e-04
## ASV0977     -3.556242e-04 -3.711186e-04 -3.872257e-04 -4.039643e-04
## ASV0140      1.791065e-04  1.872306e-04  1.957044e-04  2.045410e-04
## ASV14421    -2.148740e-04 -2.246702e-04 -2.348927e-04 -2.455581e-04
## ASV16909    -4.779177e-05 -5.007401e-05 -5.246506e-05 -5.497002e-05
## ASV3762     -2.148533e-04 -2.246476e-04 -2.348679e-04 -2.455310e-04
## ASV7141     -2.148359e-04 -2.246285e-04 -2.348471e-04 -2.455082e-04
## ASV3291      3.413499e-04  3.571855e-04  3.737356e-04  3.910308e-04
## ASV10440    -2.148157e-04 -2.246064e-04 -2.348229e-04 -2.454818e-04
## ASV10802     6.556423e-05  6.850611e-05  7.157163e-05  7.476522e-05
## ASV1698      3.583478e-05  3.758009e-05  3.941196e-05  4.133476e-05
## ASV2121      2.148028e-04  2.245923e-04  2.348075e-04  2.454650e-04
## ASV3549     -3.033212e-04 -3.171885e-04 -3.316625e-04 -3.467672e-04
## ASV6379      2.538189e-04  2.651085e-04  2.768641e-04  2.891018e-04
## ASV6824     -2.147643e-04 -2.245503e-04 -2.347616e-04 -2.454148e-04
## ASV8254      2.230395e-05  2.341436e-05  2.458176e-05  2.580918e-05
## ASV9951      9.449028e-05  9.896140e-05  1.036424e-04  1.085428e-04
## ASV1515     -8.996334e-05 -9.388336e-05 -9.795682e-05 -1.021881e-04
## ASV4327      6.552318e-05  6.851844e-05  7.164499e-05  7.490809e-05
## ASV0341     -9.963865e-05 -1.043572e-04 -1.092974e-04 -1.144692e-04
## ASV5562     -1.753112e-04 -1.835381e-04 -1.921452e-04 -2.011496e-04
## ASV1412      4.809637e-04  5.030260e-04  5.260618e-04  5.501104e-04
## ASV0154     -3.869418e-04 -4.048674e-04 -4.235999e-04 -4.431736e-04
## ASV3163     -1.791504e-04 -1.872538e-04 -1.957047e-04 -2.045163e-04
## ASV1782     -2.854375e-04 -2.984853e-04 -3.121032e-04 -3.263135e-04
## ASV3993     -3.098936e-05 -3.224215e-05 -3.353470e-05 -3.486723e-05
## ASV3164      1.373883e-04  1.434696e-04  1.497983e-04  1.563825e-04
## ASV1024      1.740900e-05  1.834426e-05  1.933381e-05  2.038110e-05
## ASV0771     -3.903935e-04 -4.078484e-04 -4.260311e-04 -4.449674e-04
## ASV2223     -1.726879e-04 -1.809066e-04 -1.895134e-04 -1.985262e-04
## ASV1638      6.457218e-04  6.749518e-04  7.054348e-04  7.372185e-04
## ASV0232     -1.895240e-04 -1.981366e-04 -2.071216e-04 -2.164933e-04
## ASV6771     -2.097877e-04 -2.196244e-04 -2.299133e-04 -2.406741e-04
## ASV4243     -8.262401e-05 -8.616092e-05 -8.983334e-05 -9.364528e-05
## ASV0162     -3.869614e-04 -4.046490e-04 -4.231089e-04 -4.423713e-04
## ASV0049      2.672946e-05  2.796944e-05  2.926557e-05  3.062027e-05
## ASV4697     -2.157753e-04 -2.256549e-04 -2.359682e-04 -2.467326e-04
## ASV12326     6.883093e-05  7.179745e-05  7.487732e-05  7.807355e-05
## ASV12586    -2.157605e-04 -2.256386e-04 -2.359504e-04 -2.467131e-04
## ASV1879      1.708171e-04  1.786533e-04  1.868344e-04  1.953744e-04
## ASV2864      4.708878e-04  4.926634e-04  5.154152e-04  5.391841e-04
## ASV3111     -1.254766e-04 -1.311997e-04 -1.371721e-04 -1.434035e-04
## ASV5633     -1.204026e-04 -1.258608e-04 -1.315536e-04 -1.374899e-04
## ASV5864      7.319206e-05  7.612732e-05  7.915402e-05  8.227252e-05
## ASV6364      1.037194e-04  1.086529e-04  1.138203e-04  1.192328e-04
## ASV1598      1.332140e-04  1.393411e-04  1.457410e-04  1.524249e-04
## ASV2649     -7.927729e-05 -8.315313e-05 -8.722178e-05 -9.149300e-05
## ASV4664      1.776495e-04  1.855936e-04  1.938700e-04  2.024904e-04
## ASV2654      2.991994e-04  3.128333e-04  3.270595e-04  3.419010e-04
## ASV6636     -2.075109e-05 -2.199166e-05 -2.331214e-05 -2.471787e-05
## ASV3334      2.228819e-04  2.334088e-04  2.444273e-04  2.559601e-04
## ASV0046     -3.972653e-04 -4.159274e-04 -4.354528e-04 -4.558800e-04
## ASV0661      4.021939e-04  4.202773e-04  4.391252e-04  4.587656e-04
## ASV0774      1.805278e-04  1.888142e-04  1.974658e-04  2.064974e-04
## ASV3815      2.157354e-04  2.254861e-04  2.356528e-04  2.462513e-04
## ASV0575      2.174012e-04  2.269875e-04  2.369623e-04  2.473384e-04
## ASV1953     -3.003801e-04 -3.141198e-04 -3.284609e-04 -3.434271e-04
## ASV0610      9.055083e-05  9.456406e-05  9.874183e-05  1.030897e-04
## ASV0245     -1.097225e-04 -1.147769e-04 -1.200561e-04 -1.255694e-04
## ASV3805     -1.588558e-04 -1.654034e-04 -1.721766e-04 -1.791792e-04
## ASV1182      4.483650e-04  4.693014e-04  4.911956e-04  5.140893e-04
## ASV1941      1.055174e-06  1.155843e-06  1.265980e-06  1.386455e-06
## ASV0080     -5.274757e-04 -5.515111e-04 -5.765908e-04 -6.027555e-04
## ASV1033      1.575404e-04  1.647574e-04  1.722916e-04  1.801558e-04
## ASV5330     -1.893765e-04 -1.979480e-04 -2.068863e-04 -2.162052e-04
## ASV9702     -2.898958e-04 -3.025006e-04 -3.156013e-04 -3.292131e-04
## ASV0358      7.786725e-06  7.993816e-06  8.196143e-06  8.392238e-06
## ASV2225      1.497430e-04  1.565308e-04  1.636101e-04  1.709920e-04
## ASV2606      6.868220e-06  7.043421e-06  7.213101e-06  7.375780e-06
## ASV3510     -2.332225e-04 -2.438955e-04 -2.550366e-04 -2.666643e-04
## ASV3069      7.993445e-05  8.330522e-05  8.679914e-05  9.041910e-05
## ASV3849      1.448988e-04  1.513411e-04  1.580486e-04  1.650300e-04
## ASV1810     -3.648415e-04 -3.808634e-04 -3.975302e-04 -4.148628e-04
## ASV2046      5.353367e-04  5.600059e-04  5.857726e-04  6.126817e-04
## ASV2451     -6.480151e-05 -6.807914e-05 -7.152838e-05 -7.515849e-05
## ASV4047      2.796700e-04  2.923819e-04  3.056438e-04  3.194770e-04
## ASV7402     -2.208141e-04 -2.311522e-04 -2.419641e-04 -2.532706e-04
## ASV8250      2.710905e-04  2.837063e-04  2.968949e-04  3.106811e-04
## ASV3468      2.329085e-04  2.434879e-04  2.545242e-04  2.660349e-04
## ASV3521      4.788713e-04  5.008664e-04  5.238341e-04  5.478140e-04
## ASV6363     -1.626084e-04 -1.702916e-04 -1.783331e-04 -1.867490e-04
## ASV6444      1.087627e-04  1.139034e-04  1.192858e-04  1.249214e-04
## ASV8231      1.258845e-04  1.315375e-04  1.374292e-04  1.435681e-04
## ASV0196     -7.177327e-04 -7.503994e-04 -7.844827e-04 -8.200377e-04
## ASV12801    -2.208233e-04 -2.311621e-04 -2.419749e-04 -2.532822e-04
## ASV12906    -2.208049e-04 -2.311420e-04 -2.419528e-04 -2.532581e-04
## ASV13040    -2.207865e-04 -2.311218e-04 -2.419307e-04 -2.532339e-04
## ASV1313     -2.236729e-05 -2.364784e-05 -2.500785e-05 -2.645256e-05
## ASV14008     6.227647e-05  6.532915e-05  6.853611e-05  7.190561e-05
## ASV1546      8.528393e-05  8.889202e-05  9.263179e-05  9.650615e-05
## ASV1637      4.147096e-04  4.336470e-04  4.534105e-04  4.740327e-04
## ASV17076     1.801438e-04  1.881618e-04  1.965108e-04  2.052021e-04
## ASV2061      6.173076e-04  6.450861e-04  6.740405e-04  7.042138e-04
## ASV2177      2.548361e-04  2.668672e-04  2.794605e-04  2.926415e-04
## ASV2943      3.758092e-04  3.928656e-04  4.106564e-04  4.292097e-04
## ASV3020      3.313008e-04  3.462328e-04  3.617986e-04  3.780215e-04
## ASV30254     1.634810e-05  1.680945e-05  1.726574e-05  1.771463e-05
## ASV3219      4.648487e-04  4.858376e-04  5.077215e-04  5.305337e-04
## ASV3352      4.059274e-04  4.246208e-04  4.441454e-04  4.645354e-04
## ASV3355      1.741198e-04  1.822727e-04  1.907991e-04  1.997151e-04
## ASV3377      3.153434e-04  3.298449e-04  3.449896e-04  3.608039e-04
## ASV3449      1.837120e-04  1.918242e-04  2.002654e-04  2.090465e-04
## ASV3893      2.207669e-04  2.311002e-04  2.419070e-04  2.532077e-04
## ASV4326      1.296653e-04  1.352964e-04  1.411473e-04  1.472242e-04
## ASV5016     -2.207540e-04 -2.310861e-04 -2.418914e-04 -2.531906e-04
## ASV5152      1.720597e-04  1.793921e-04  1.869977e-04  1.948829e-04
## ASV5666     -8.432208e-06 -8.991209e-06 -9.589731e-06 -1.023059e-05
## ASV5802     -2.261795e-04 -2.367484e-04 -2.478000e-04 -2.593551e-04
## ASV6070      1.571708e-04  1.641059e-04  1.713218e-04  1.788277e-04
## ASV6488      1.364209e-04  1.425861e-04  1.490147e-04  1.557165e-04
## ASV6562     -2.207239e-04 -2.310531e-04 -2.418552e-04 -2.531508e-04
## ASV6930      1.612993e-04  1.684257e-04  1.758416e-04  1.835564e-04
## ASV7243      2.919784e-04  3.050942e-04  3.187629e-04  3.330045e-04
## ASV7506      1.856105e-04  1.938675e-04  2.024652e-04  2.114150e-04
## ASV7553     -2.207104e-04 -2.310381e-04 -2.418388e-04 -2.531328e-04
## ASV8064      1.261068e-04  1.317239e-04  1.375731e-04  1.436621e-04
## ASV8434     -1.226425e-04 -1.284958e-04 -1.346271e-04 -1.410492e-04
## ASV8858     -2.206880e-04 -2.310137e-04 -2.418119e-04 -2.531033e-04
## ASV2600      1.270046e-04  1.329457e-04  1.391582e-04  1.456541e-04
## ASV3398      4.780038e-04  5.000234e-04  5.230228e-04  5.470422e-04
## ASV4584     -2.206612e-04 -2.309842e-04 -2.417797e-04 -2.530680e-04
## ASV4864      2.418836e-04  2.529130e-04  2.644226e-04  2.764314e-04
## ASV0082     -9.445543e-04 -9.877160e-04 -1.032766e-03 -1.079778e-03
## ASV9626      1.950834e-04  2.040427e-04  2.133975e-04  2.231638e-04
## ASV1617      8.539668e-05  8.893879e-05  9.260362e-05  9.639326e-05
## ASV2765     -5.036788e-05 -5.288469e-05 -5.553058e-05 -5.831229e-05
## ASV2167     -2.933610e-04 -3.067453e-04 -3.207130e-04 -3.352868e-04
## ASV1628      1.859770e-04  1.939266e-04  2.021755e-04  2.107315e-04
## ASV3260     -4.653397e-05 -4.851586e-05 -5.057099e-05 -5.270102e-05
## ASV3645      2.720005e-05  2.865510e-05  3.019124e-05  3.181299e-05
## ASV6057     -2.799384e-04 -2.927157e-04 -3.060505e-04 -3.199647e-04
## ASV0662     -3.740247e-05 -3.898455e-05 -4.062439e-05 -4.232327e-05
## ASV4267     -3.577000e-05 -3.749990e-05 -3.931347e-05 -4.121467e-05
## ASV1070      2.990308e-04  3.130316e-04  3.276765e-04  3.429939e-04
## ASV0633     -7.749089e-05 -8.090229e-05 -8.445113e-05 -8.814179e-05
## ASV0333      3.069312e-04  3.211005e-04  3.359034e-04  3.513664e-04
## ASV0966      2.333534e-04  2.440946e-04  2.553121e-04  2.670253e-04
## ASV1848      3.363690e-04  3.521766e-04  3.687163e-04  3.860210e-04
## ASV13390    -2.143685e-04 -2.241172e-04 -2.342877e-04 -2.448964e-04
## ASV14901    -2.143511e-04 -2.240982e-04 -2.342670e-04 -2.448737e-04
## ASV1676     -2.465153e-04 -2.574635e-04 -2.688614e-04 -2.807244e-04
## ASV1756     -2.587506e-05 -2.704013e-05 -2.825439e-05 -2.951963e-05
## ASV22537    -2.968866e-05 -3.095443e-05 -3.226734e-05 -3.362854e-05
## ASV3303     -3.516106e-06 -3.757195e-06 -4.015676e-06 -4.292789e-06
## ASV4030     -8.954173e-05 -9.354110e-05 -9.770680e-05 -1.020446e-04
## ASV4871      1.713502e-04  1.792864e-04  1.875798e-04  1.962455e-04
## ASV5536      1.060136e-05  1.108632e-05  1.159281e-05  1.212175e-05
## ASV5700      7.672643e-05  8.023301e-05  8.389262e-05  8.771124e-05
## ASV8957      1.422932e-04  1.482581e-04  1.544359e-04  1.608309e-04
## ASV11210     1.369337e-04  1.435631e-04  1.505173e-04  1.578125e-04
## ASV7585     -2.143445e-04 -2.240910e-04 -2.342591e-04 -2.448651e-04
## ASV8596     -2.143272e-04 -2.240720e-04 -2.342383e-04 -2.448425e-04
## ASV9532     -8.607876e-05 -8.989607e-05 -9.386952e-05 -9.800432e-05
## ASV4254      1.551744e-04  1.623788e-04  1.699087e-04  1.777779e-04
## ASV13299    -2.143118e-04 -2.240552e-04 -2.342200e-04 -2.448225e-04
## ASV15627    -2.142944e-04 -2.240362e-04 -2.341993e-04 -2.447998e-04
## ASV6302     -1.706384e-04 -1.777654e-04 -1.851469e-04 -1.927885e-04
## ASV3040      8.621529e-05  9.017534e-05  9.431027e-05  9.862717e-05
## ASV0632      1.755613e-04  1.836617e-04  1.921239e-04  2.009632e-04
## ASV3694      2.792384e-04  2.920105e-04  3.053421e-04  3.192553e-04
## ASV1592     -5.228777e-05 -5.440599e-05 -5.659293e-05 -5.884927e-05
## ASV0538      1.423214e-04  1.490137e-04  1.560172e-04  1.633461e-04
## ASV0832      3.119256e-04  3.261488e-04  3.409915e-04  3.564780e-04
## ASV0727      2.355983e-04  2.466585e-04  2.582302e-04  2.703361e-04
## ASV1165     -3.027012e-04 -3.166384e-04 -3.311952e-04 -3.463970e-04
## ASV1325      3.365340e-05  3.579442e-05  3.808560e-05  4.053821e-05
## ASV0819      5.432013e-04  5.681795e-04  5.942654e-04  6.215042e-04
## ASV2251      2.911663e-04  3.035616e-04  3.164168e-04  3.297431e-04
## ASV0100     -1.865057e-05 -1.947259e-05 -2.032754e-05 -2.121641e-05
## ASV0444     -1.448180e-04 -1.514833e-04 -1.584456e-04 -1.657177e-04
## ASV0800      7.097577e-04  7.415013e-04  7.745721e-04  8.090174e-04
## ASV2432      1.619345e-05  1.668948e-05  1.718641e-05  1.768260e-05
## ASV2883      1.985932e-05  2.060627e-05  2.137094e-05  2.215263e-05
## ASV3894      2.261309e-05  2.336691e-05  2.412791e-05  2.489401e-05
## ASV2367      4.964026e-04  5.190101e-04  5.425997e-04  5.672097e-04
## ASV3724     -2.951776e-04 -3.085208e-04 -3.224343e-04 -3.369394e-04
## ASV2112     -2.519363e-04 -2.635332e-04 -2.756444e-04 -2.882910e-04
## ASV3661      8.719495e-05  9.129367e-05  9.558247e-05  1.000699e-04
## ASV2096     -1.823951e-04 -1.910131e-04 -2.000323e-04 -2.094705e-04
## ASV3551     -2.112460e-04 -2.206668e-04 -2.304773e-04 -2.406909e-04
## ASV11343    -7.144555e-06 -7.579348e-06 -8.043385e-06 -8.538796e-06
## ASV2051      1.810439e-04  1.894480e-04  1.982335e-04  2.074170e-04
## ASV2617     -2.486843e-04 -2.600098e-04 -2.718270e-04 -2.841550e-04
## ASV0125     -1.100759e-04 -1.151468e-04 -1.204425e-04 -1.259723e-04
## ASV0372      3.790115e-04  3.962731e-04  4.142842e-04  4.330740e-04
## ASV6751     -2.832249e-04 -2.959877e-04 -3.092924e-04 -3.231592e-04
## ASV10810     6.341061e-05  6.632343e-05  6.936580e-05  7.254317e-05
## ASV0461     -1.616860e-04 -1.692096e-04 -1.770747e-04 -1.852961e-04
## ASV1945     -9.589435e-05 -1.004230e-04 -1.051633e-04 -1.101250e-04
## ASV0882     -8.199896e-05 -8.614468e-05 -9.050815e-05 -9.510130e-05
## ASV4040     -4.121012e-05 -4.309774e-05 -4.506726e-05 -4.712170e-05
## ASV0109     -2.811642e-06 -2.912568e-06 -3.015152e-06 -3.119180e-06
## ASV0174      1.273266e-04  1.326869e-04  1.382391e-04  1.439869e-04
## ASV2851      2.179159e-04  2.274577e-04  2.373784e-04  2.476893e-04
## ASV5312      3.685147e-05  3.851870e-05  4.025912e-05  4.207591e-05
## ASV9402     -3.035879e-04 -3.173279e-04 -3.316563e-04 -3.465955e-04
## ASV4870     -2.452698e-04 -2.563002e-04 -2.677969e-04 -2.797770e-04
## ASV0589      2.931800e-04  3.065751e-04  3.205558e-04  3.351454e-04
## ASV1221      6.849615e-07  7.461240e-07  8.124809e-07  8.844373e-07
## ASV6028     -2.836794e-04 -2.966007e-04 -3.100838e-04 -3.241506e-04
## ASV5106     -1.067563e-04 -1.114789e-04 -1.163939e-04 -1.215076e-04
## ASV4977     -3.849248e-05 -4.061403e-05 -4.286095e-05 -4.524107e-05
## ASV5715     -1.863759e-04 -1.948789e-04 -2.037527e-04 -2.130119e-04
## ASV4182      7.035262e-05  7.384942e-05  7.752589e-05  8.139173e-05
## ASV2383     -1.540181e-05 -1.643382e-05 -1.754215e-05 -1.873280e-05
## ASV3985      3.347550e-04  3.503717e-04  3.667015e-04  3.837753e-04
## ASV2787     -2.515044e-04 -2.626543e-04 -2.742618e-04 -2.863424e-04
## ASV6756     -2.164802e-04 -2.264829e-04 -2.369326e-04 -2.478479e-04
## ASV1634     -3.463818e-04 -3.619130e-04 -3.780963e-04 -3.949552e-04
## ASV0649     -1.060782e-04 -1.109645e-04 -1.160675e-04 -1.213960e-04
## ASV1591     -6.622112e-06 -7.221900e-06 -7.873878e-06 -8.582301e-06
## ASV1854      3.596279e-04  3.764589e-04  3.940627e-04  4.124731e-04
## ASV4205      2.398101e-04  2.510345e-04  2.627746e-04  2.750530e-04
## ASV3293     -1.385431e-04 -1.447434e-04 -1.512031e-04 -1.579314e-04
## ASV1631      1.629145e-04  1.703748e-04  1.781634e-04  1.862938e-04
## ASV1747     -9.267427e-05 -9.712972e-05 -1.018004e-04 -1.066966e-04
## ASV5634      7.380603e-05  7.717347e-05  8.068819e-05  8.435612e-05
## ASV0965     -1.162031e-04 -1.214583e-04 -1.269387e-04 -1.326528e-04
## ASV1094      2.005242e-04  2.096002e-04  2.190657e-04  2.289355e-04
## ASV2744     -6.746395e-06 -7.357082e-06 -8.020859e-06 -8.742048e-06
## ASV7212     -3.039200e-04 -3.180473e-04 -3.328133e-04 -3.482449e-04
## ASV0344     -2.013527e-04 -2.105696e-04 -2.201912e-04 -2.302337e-04
## ASV11812    -2.180619e-04 -2.281494e-04 -2.386888e-04 -2.496990e-04
## ASV7867     -3.164203e-05 -3.319395e-05 -3.482297e-05 -3.653291e-05
## ASV6670      1.979261e-04  2.065919e-04  2.156036e-04  2.249723e-04
## ASV10991     3.636133e-06  3.348887e-06  3.008503e-06  2.609351e-06
## ASV1281      3.897812e-04  4.081566e-04  4.273879e-04  4.475139e-04
## ASV12845    -2.180464e-04 -2.281324e-04 -2.386702e-04 -2.496785e-04
## ASV1833     -2.180285e-04 -2.281128e-04 -2.386487e-04 -2.496550e-04
## ASV2211      1.416269e-04  1.478152e-04  1.542487e-04  1.609350e-04
## ASV3920      3.069843e-04  3.207252e-04  3.350403e-04  3.499499e-04
## ASV4545     -2.477275e-04 -2.592053e-04 -2.711990e-04 -2.837303e-04
## ASV4710     -2.704857e-04 -2.829867e-04 -2.960468e-04 -3.096892e-04
## ASV4978      4.309424e-05  4.510291e-05  4.720315e-05  4.939893e-05
## ASV9630     -7.583905e-06 -7.958315e-06 -8.351523e-06 -8.764475e-06
## ASV9797     -7.728571e-06 -8.359181e-06 -9.042506e-06 -9.782869e-06
## ASV13469    -2.179805e-04 -2.280602e-04 -2.385911e-04 -2.495918e-04
## ASV14961    -7.955266e-05 -8.322061e-05 -8.705163e-05 -9.105238e-05
## ASV6259      1.223613e-04  1.277823e-04  1.334246e-04  1.392957e-04
## ASV6294     -1.552065e-04 -1.623887e-04 -1.698928e-04 -1.777321e-04
## ASV6883     -7.276309e-05 -7.623158e-05 -7.986450e-05 -8.366948e-05
## ASV7041     -1.801818e-04 -1.886776e-04 -1.975682e-04 -2.068712e-04
## ASV4363     -2.112092e-04 -2.206702e-04 -2.305278e-04 -2.407963e-04
## ASV1784     -3.079506e-04 -3.220316e-04 -3.367295e-04 -3.520687e-04
## ASV2140      2.743622e-05  2.874110e-05  3.010698e-05  3.153651e-05
## ASV3202      2.111818e-04  2.206403e-04  2.304951e-04  2.407607e-04
## ASV6017     -2.111650e-04 -2.206219e-04 -2.304751e-04 -2.407388e-04
## ASV9129      1.061521e-04  1.108255e-04  1.156867e-04  1.207416e-04
## ASV0917      2.166079e-04  2.263226e-04  2.364458e-04  2.469922e-04
## ASV10584    -2.998924e-06 -2.890014e-06 -2.754740e-06 -2.590234e-06
## ASV11218     1.373710e-04  1.434388e-04  1.497524e-04  1.563198e-04
## ASV11229     2.015075e-05  2.131494e-05  2.255136e-05  2.386468e-05
## ASV11604    -2.427651e-05 -2.550009e-05 -2.678748e-05 -2.814210e-05
## ASV2103     -2.480425e-04 -2.592617e-04 -2.709615e-04 -2.831603e-04
## ASV2165     -2.111176e-04 -2.205702e-04 -2.304187e-04 -2.406773e-04
## ASV2340      2.342780e-04  2.444580e-04  2.550359e-04  2.660234e-04
## ASV3738     -2.110979e-04 -2.205487e-04 -2.303953e-04 -2.406518e-04
## ASV4012      6.407923e-05  6.694370e-05  6.992736e-05  7.303436e-05
## ASV4094     -2.110839e-04 -2.205334e-04 -2.303785e-04 -2.406335e-04
## ASV4454     -2.110670e-04 -2.205150e-04 -2.303585e-04 -2.406116e-04
## ASV7031      5.002966e-05  5.246030e-05  5.501042e-05  5.768593e-05
## ASV7087     -8.056285e-05 -8.399756e-05 -8.756067e-05 -9.125541e-05
## ASV4159      1.239085e-05  1.290041e-05  1.342688e-05  1.397044e-05
## ASV5084     -2.110481e-04 -2.204944e-04 -2.303360e-04 -2.405871e-04
## ASV6584     -2.110313e-04 -2.204760e-04 -2.303160e-04 -2.405653e-04
## ASV9614     -2.110144e-04 -2.204577e-04 -2.302960e-04 -2.405434e-04
## ASV16068    -2.109976e-04 -2.204393e-04 -2.302759e-04 -2.405216e-04
## ASV2141     -2.803886e-04 -2.925381e-04 -3.051622e-04 -3.182753e-04
## ASV0395     -1.990368e-05 -2.087250e-05 -2.188949e-05 -2.295713e-05
## ASV5640     -4.927217e-05 -5.164747e-05 -5.413746e-05 -5.674757e-05
## ASV2854     -2.372572e-04 -2.478020e-04 -2.587818e-04 -2.702115e-04
## ASV3825     -4.183630e-04 -4.374008e-04 -4.572645e-04 -4.779863e-04
## ASV0481      4.556109e-04  4.758083e-04  4.968350e-04  5.187194e-04
## ASV3304      2.130589e-05  2.231625e-05  2.337444e-05  2.448274e-05
## ASV0445      2.774170e-04  2.899395e-04  3.029956e-04  3.166052e-04
## ASV1845     -1.459088e-04 -1.527397e-04 -1.598840e-04 -1.673554e-04
## ASV3110     -1.607408e-04 -1.679960e-04 -1.755625e-04 -1.834522e-04
##                                                                    
## (Intercept) -4.233900e-06 -4.916363e-06 -5.706143e-06 -6.619401e-06
## ASV1236      2.599698e-04  2.714880e-04  2.834758e-04  2.959488e-04
## ASV0421     -4.555862e-04 -4.756031e-04 -4.964248e-04 -5.180772e-04
## ASV0691     -3.905978e-04 -4.071273e-04 -4.242658e-04 -4.420281e-04
## ASV0899      1.269440e-06  1.866026e-06  2.533200e-06  3.277139e-06
## ASV1004      5.185855e-04  5.414099e-04  5.651540e-04  5.898476e-04
## ASV1041     -3.548459e-04 -3.706534e-04 -3.871144e-04 -4.042514e-04
## ASV1058      4.833417e-04  5.046924e-04  5.269121e-04  5.500298e-04
## ASV12542     1.453804e-04  1.515020e-04  1.578467e-04  1.644196e-04
## ASV1294      5.655086e-04  5.908067e-04  6.171622e-04  6.446128e-04
## ASV13113     1.999424e-04  2.090565e-04  2.185679e-04  2.284924e-04
## ASV1318      4.942390e-04  5.162679e-04  5.392091e-04  5.630942e-04
## ASV2269     -1.506629e-04 -1.575263e-04 -1.646848e-04 -1.721494e-04
## ASV2542      3.221639e-04  3.371697e-04  3.528572e-04  3.692559e-04
## ASV2660     -2.853490e-04 -2.979580e-04 -3.110778e-04 -3.247250e-04
## ASV2737     -2.043277e-05 -2.169288e-05 -2.303373e-05 -2.446031e-05
## ASV2840      3.691833e-04  3.849673e-04  4.013458e-04  4.183340e-04
## ASV3053      1.831506e-05  1.900617e-05  1.971741e-05  2.044906e-05
## ASV3077      1.165741e-04  1.216791e-04  1.269899e-04  1.325137e-04
## ASV3134      4.103789e-04  4.293829e-04  4.492433e-04  4.699966e-04
## ASV3140      1.843684e-04  1.929867e-04  2.019954e-04  2.114106e-04
## ASV3579      7.204083e-05  7.556974e-05  7.927673e-05  8.317122e-05
## ASV6119     -1.506322e-04 -1.574928e-04 -1.646481e-04 -1.721093e-04
## ASV7557     -1.506175e-04 -1.574767e-04 -1.646305e-04 -1.720900e-04
## ASV8422      7.493782e-05  7.789895e-05  8.095176e-05  8.409704e-05
## ASV1086     -3.903780e-05 -4.065832e-05 -4.233795e-05 -4.407834e-05
## ASV1310      2.772197e-04  2.895308e-04  3.023491e-04  3.156919e-04
## ASV15750    -7.324321e-05 -7.661265e-05 -8.012824e-05 -8.379528e-05
## ASV16905    -1.506096e-04 -1.574679e-04 -1.646209e-04 -1.720794e-04
## ASV2033      2.710445e-04  2.832715e-04  2.960196e-04  3.093085e-04
## ASV2089      1.039860e-04  1.087656e-04  1.137535e-04  1.189576e-04
## ASV2127      3.952202e-04  4.125138e-04  4.304951e-04  4.491853e-04
## ASV2725      4.484086e-04  4.678611e-04  4.880742e-04  5.090704e-04
## ASV2804     -1.506042e-04 -1.574620e-04 -1.646144e-04 -1.720722e-04
## ASV3075      2.834908e-04  2.959833e-04  3.089833e-04  3.225077e-04
## ASV3327      2.677099e-04  2.798712e-04  2.925595e-04  3.057953e-04
## ASV3342      2.981203e-04  3.118201e-04  3.261237e-04  3.410552e-04
## ASV3532     -2.672734e-04 -2.794499e-04 -2.921526e-04 -3.054016e-04
## ASV3600      3.325838e-04  3.474647e-04  3.629701e-04  3.791225e-04
## ASV4013      2.784254e-04  2.906576e-04  3.033815e-04  3.166130e-04
## ASV4136      2.809241e-04  2.933378e-04  3.062558e-04  3.196948e-04
## ASV4195      1.505815e-04  1.574371e-04  1.645872e-04  1.720425e-04
## ASV4407     -1.505668e-04 -1.574210e-04 -1.645696e-04 -1.720232e-04
## ASV4717      1.533400e-06  1.211703e-06  8.446941e-07  4.283361e-07
## ASV6794      1.441315e-04  1.500671e-04  1.562084e-04  1.625596e-04
## ASV8324     -1.505604e-04 -1.574139e-04 -1.645616e-04 -1.720144e-04
## ASV8981     -4.319437e-05 -4.512716e-05 -4.713807e-05 -4.922935e-05
## ASV9859      1.120831e-04  1.173979e-04  1.229647e-04  1.287956e-04
## ASV0936     -2.272722e-04 -2.372936e-04 -2.477228e-04 -2.585738e-04
## ASV12683    -2.820900e-05 -2.973886e-05 -3.135406e-05 -3.305923e-05
## ASV1293      3.371226e-04  3.519047e-04  3.672756e-04  3.832533e-04
## ASV13055    -3.931751e-05 -4.115189e-05 -4.306668e-05 -4.506471e-05
## ASV17063    -1.505335e-04 -1.573846e-04 -1.645297e-04 -1.719796e-04
## ASV2228      1.505188e-04  1.573685e-04  1.645121e-04  1.719604e-04
## ASV2769     -3.144116e-05 -3.288503e-05 -3.439049e-05 -3.595962e-05
## ASV2803      6.233483e-05  6.467921e-05  6.708489e-05  6.955118e-05
## ASV2896      1.804983e-04  1.885063e-04  1.968465e-04  2.055310e-04
## ASV3062      5.464953e-05  5.725348e-05  5.998234e-05  6.284217e-05
## ASV3107      2.197987e-04  2.296501e-04  2.399167e-04  2.506140e-04
## ASV3265      4.360813e-04  4.551016e-04  4.748727e-04  4.954173e-04
## ASV3666     -1.294981e-05 -1.366893e-05 -1.442843e-05 -1.523041e-05
## ASV4497      1.026064e-04  1.070860e-04  1.117457e-04  1.165914e-04
## ASV6914     -5.727926e-05 -6.012929e-05 -6.312154e-05 -6.626277e-05
## ASV0576     -5.116522e-04 -5.335407e-04 -5.562576e-04 -5.798251e-04
## ASV0673      1.399781e-04  1.467041e-04  1.537523e-04  1.611377e-04
## ASV0772      1.524196e-04  1.590193e-04  1.658779e-04  1.730036e-04
## ASV0862     -1.238090e-04 -1.289999e-04 -1.343783e-04 -1.399486e-04
## ASV0898      1.336611e-04  1.400277e-04  1.466941e-04  1.536736e-04
## ASV0910      2.880248e-04  3.015913e-04  3.157882e-04  3.306438e-04
## ASV0964     -1.862125e-04 -1.942844e-04 -2.026726e-04 -2.113867e-04
## ASV10059     1.318945e-04  1.380397e-04  1.444673e-04  1.511902e-04
## ASV10263    -1.505883e-04 -1.574442e-04 -1.645944e-04 -1.720498e-04
## ASV1088      1.515924e-04  1.586870e-04  1.661081e-04  1.738701e-04
## ASV1101      2.540419e-04  2.654083e-04  2.772502e-04  2.895847e-04
## ASV1183      1.687225e-04  1.765957e-04  1.848252e-04  1.934259e-04
## ASV11956     5.642655e-05  5.849059e-05  6.060267e-05  6.276150e-05
## ASV12774    -2.844606e-05 -3.005092e-05 -3.175005e-05 -3.354888e-05
## ASV1321      6.466310e-05  6.784808e-05  7.119330e-05  7.470694e-05
## ASV13793    -1.505684e-04 -1.574222e-04 -1.645703e-04 -1.720233e-04
## ASV14482    -1.853604e-05 -1.965295e-05 -2.083916e-05 -2.209873e-05
## ASV15483     9.801069e-05  1.022500e-04  1.066559e-04  1.112337e-04
## ASV2062      6.492759e-04  6.784702e-04  7.088990e-04  7.406074e-04
## ASV2132      2.905900e-04  3.036405e-04  3.172435e-04  3.314193e-04
## ASV2413      4.146842e-04  4.329207e-04  4.518942e-04  4.716290e-04
## ASV2490      2.739596e-04  2.859153e-04  2.983442e-04  3.112610e-04
## ASV2594      1.473156e-04  1.537753e-04  1.604973e-04  1.674907e-04
## ASV2822     -1.505879e-04 -1.574435e-04 -1.645934e-04 -1.720484e-04
## ASV2863      2.575621e-04  2.690066e-04  2.809209e-04  2.933209e-04
## ASV2910      3.255099e-04  3.395113e-04  3.540497e-04  3.691401e-04
## ASV2980      1.248064e-04  1.304822e-04  1.364006e-04  1.425704e-04
## ASV3307      1.505619e-04  1.574149e-04  1.645621e-04  1.720142e-04
## ASV3474      2.314920e-04  2.422898e-04  2.535818e-04  2.653897e-04
## ASV3502      4.738694e-04  4.949670e-04  5.169390e-04  5.398158e-04
## ASV4236      2.385638e-04  2.488753e-04  2.595871e-04  2.707107e-04
## ASV4842     -8.470206e-05 -8.869028e-05 -9.285980e-05 -9.721798e-05
## ASV4894     -1.505762e-04 -1.574306e-04 -1.645792e-04 -1.720327e-04
## ASV5290      1.787441e-04  1.867156e-04  1.950199e-04  2.036688e-04
## ASV5501      3.189740e-05  3.326085e-05  3.467867e-05  3.615294e-05
## ASV5795      1.188186e-04  1.241489e-04  1.297056e-04  1.354974e-04
## ASV5987     -1.505803e-04 -1.574350e-04 -1.645840e-04 -1.720380e-04
## ASV6267     -1.505656e-04 -1.574189e-04 -1.645664e-04 -1.720188e-04
## ASV6862      2.766384e-04  2.884142e-04  3.006309e-04  3.133000e-04
## ASV7145      4.689147e-05  4.867955e-05  5.051797e-05  5.240676e-05
## ASV7673     -1.505602e-04 -1.574129e-04 -1.645597e-04 -1.720114e-04
## ASV7789      5.055811e-05  5.295007e-05  5.545584e-05  5.808092e-05
## ASV7809     -2.214155e-05 -2.315552e-05 -2.421138e-05 -2.531025e-05
## ASV8002     -1.505478e-04 -1.573995e-04 -1.645451e-04 -1.719954e-04
## ASV8205      7.755883e-05  8.071025e-05  8.396744e-05  8.733217e-05
## ASV9155     -1.142914e-04 -1.195083e-04 -1.249495e-04 -1.306232e-04
## ASV9221     -2.481654e-05 -2.612243e-05 -2.749821e-05 -2.894745e-05
## ASV9311     -1.505251e-04 -1.573746e-04 -1.645178e-04 -1.719655e-04
## ASV9557     -1.505104e-04 -1.573585e-04 -1.645002e-04 -1.719463e-04
## ASV9936     -1.504957e-04 -1.573424e-04 -1.644826e-04 -1.719271e-04
## ASV1445      3.386281e-04  3.540035e-04  3.700434e-04  3.867733e-04
## ASV4232      2.833835e-04  2.963036e-04  3.097894e-04  3.238638e-04
## ASV6479     -2.050248e-06 -1.879856e-06 -1.675214e-06 -1.432243e-06
## ASV0142     -7.328006e-04 -7.646692e-04 -7.977904e-04 -8.322019e-04
## ASV0378     -2.406657e-04 -2.510328e-04 -2.617978e-04 -2.729717e-04
## ASV1122      4.455861e-04  4.657474e-04  4.867738e-04  5.086982e-04
## ASV0123     -7.183192e-04 -7.495597e-04 -7.820282e-04 -8.157617e-04
## ASV2064      7.053810e-05  7.335681e-05  7.626780e-05  7.927266e-05
## ASV4459     -8.527991e-05 -8.924701e-05 -9.339080e-05 -9.771824e-05
## ASV0448      1.370033e-04  1.439381e-04  1.512327e-04  1.589060e-04
## ASV0397      3.376831e-04  3.530399e-04  3.690588e-04  3.857649e-04
## ASV0485      4.674036e-04  4.882560e-04  5.099740e-04  5.325877e-04
## ASV1566      3.858729e-04  4.030071e-04  4.208476e-04  4.394188e-04
## ASV1365      2.482248e-04  2.591912e-04  2.706050e-04  2.824814e-04
## ASV1065      5.189407e-04  5.422817e-04  5.666081e-04  5.919555e-04
## ASV0722     -7.612510e-06 -7.772032e-06 -7.924889e-06 -8.070018e-06
## ASV12660    -2.481977e-04 -2.592320e-04 -2.707190e-04 -2.826738e-04
## ASV0223     -2.369348e-06 -2.124156e-06 -1.838304e-06 -1.507749e-06
## ASV0229      2.353869e-04  2.462294e-04  2.575519e-04  2.693737e-04
## ASV0877     -9.201825e-05 -9.608268e-05 -1.003107e-04 -1.047075e-04
## ASV0983      4.769254e-04  4.981037e-04  5.201515e-04  5.430980e-04
## ASV0626     -1.534918e-04 -1.597666e-04 -1.662506e-04 -1.729466e-04
## ASV4146     -3.011944e-05 -3.158524e-05 -3.312051e-05 -3.472817e-05
## ASV4175     -2.947300e-04 -3.080559e-04 -3.219488e-04 -3.364297e-04
## ASV2082     -1.677275e-05 -1.753166e-05 -1.832594e-05 -1.915753e-05
## ASV2272      2.096453e-04  2.191236e-04  2.290098e-04  2.393199e-04
## ASV2245     -2.557497e-04 -2.673227e-04 -2.793887e-04 -2.919658e-04
## ASV0590     -1.512909e-04 -1.582678e-04 -1.655566e-04 -1.731705e-04
## ASV0217     -2.250464e-04 -2.337466e-04 -2.426881e-04 -2.518686e-04
## ASV0416      2.378906e-04  2.481129e-04  2.587234e-04  2.697321e-04
## ASV1056      2.847715e-04  2.980357e-04  3.119023e-04  3.263969e-04
## ASV7777     -2.582771e-04 -2.701467e-04 -2.825389e-04 -2.954745e-04
## ASV0455      5.414463e-05  5.681962e-05  5.962669e-05  6.257203e-05
## ASV0604      6.026647e-05  6.351845e-05  6.695696e-05  7.059318e-05
## ASV6100     -2.404542e-04 -2.516184e-04 -2.632847e-04 -2.754740e-04
## ASV11359    -2.625691e-04 -2.743709e-04 -2.866684e-04 -2.994790e-04
## ASV6604      1.875649e-04  1.962610e-04  2.053511e-04  2.148523e-04
## ASV5004     -1.573945e-04 -1.646006e-04 -1.721201e-04 -1.799651e-04
## ASV1483     -1.435753e-04 -1.501049e-04 -1.569149e-04 -1.640156e-04
## ASV9773     -3.053033e-04 -3.193350e-04 -3.339853e-04 -3.492787e-04
## ASV4059      3.139831e-05  3.315323e-05  3.501606e-05  3.699414e-05
## ASV1193      4.885211e-04  5.106037e-04  5.336327e-04  5.576444e-04
## ASV4610     -4.425184e-05 -4.593495e-05 -4.766016e-05 -4.942628e-05
## ASV0742     -1.819351e-04 -1.895952e-04 -1.975321e-04 -2.057519e-04
## ASV1502     -3.537446e-06 -3.859649e-06 -4.207409e-06 -4.582373e-06
## ASV0195     -5.331887e-05 -5.593031e-05 -5.867223e-05 -6.155122e-05
## ASV1213      1.576561e-04  1.646357e-04  1.718990e-04  1.794552e-04
## ASV1648     -2.267755e-04 -2.372084e-04 -2.481020e-04 -2.594750e-04
## ASV6984     -1.678255e-04 -1.754856e-04 -1.834773e-04 -1.918131e-04
## ASV0396     -1.147865e-04 -1.188171e-04 -1.229202e-04 -1.270901e-04
## ASV4297      2.464330e-04  2.570976e-04  2.681777e-04  2.796859e-04
## ASV2622      5.648756e-04  5.896626e-04  6.154442e-04  6.422524e-04
## ASV3512      8.563357e-05  8.972093e-05  9.400532e-05  9.849647e-05
## ASV2411      1.980075e-04  2.072444e-04  2.169015e-04  2.269967e-04
## ASV2291     -4.459700e-05 -4.657905e-05 -4.864499e-05 -5.079817e-05
## ASV0807      2.383525e-04  2.499571e-04  2.621302e-04  2.748994e-04
## ASV1292      1.338477e-04  1.400030e-04  1.464301e-04  1.531401e-04
## ASV1035      5.940395e-05  6.186805e-05  6.441637e-05  6.705010e-05
## ASV0070     -1.344996e-04 -1.401350e-04 -1.459729e-04 -1.520179e-04
## ASV0255      5.210840e-05  5.428562e-05  5.653706e-05  5.886350e-05
## ASV0057     -5.797521e-04 -6.046902e-04 -6.305817e-04 -6.574528e-04
## ASV0077     -8.514269e-05 -8.859965e-05 -9.217191e-05 -9.586129e-05
## ASV0625      5.857385e-04  6.115690e-04  6.384456e-04  6.664026e-04
## ASV2464      2.863698e-04  2.989621e-04  3.120596e-04  3.256784e-04
## ASV1315      5.005482e-04  5.231564e-04  5.467338e-04  5.713176e-04
## ASV2673      3.764067e-04  3.940142e-04  4.124282e-04  4.316840e-04
## ASV2161      1.522142e-04  1.592558e-04  1.666152e-04  1.743061e-04
## ASV0337     -2.467871e-04 -2.579322e-04 -2.695547e-04 -2.816728e-04
## ASV7680     -2.885450e-04 -3.016077e-04 -3.152280e-04 -3.294264e-04
## ASV0611      6.236275e-04  6.519745e-04  6.815494e-04  7.124001e-04
## ASV3118     -2.144510e-04 -2.242694e-04 -2.345165e-04 -2.452088e-04
## ASV1284      2.344534e-04  2.454925e-04  2.570366e-04  2.691068e-04
## ASV0889      1.686681e-04  1.760885e-04  1.838096e-04  1.918415e-04
## ASV4649     -1.833215e-04 -1.917815e-04 -2.006171e-04 -2.098436e-04
## ASV1108     -2.338461e-04 -2.448956e-04 -2.564588e-04 -2.685585e-04
## ASV0738     -2.459308e-05 -2.454601e-05 -2.439355e-05 -2.412270e-05
## ASV0473      3.648428e-05  3.818548e-05  3.996311e-05  4.182029e-05
## ASV0598     -2.577597e-04 -2.688957e-04 -2.804624e-04 -2.924722e-04
## ASV0429      4.117636e-04  4.300724e-04  4.491368e-04  4.689826e-04
## ASV1549      4.179087e-04  4.374636e-04  4.579160e-04  4.793055e-04
## ASV1203      3.090467e-04  3.227292e-04  3.369700e-04  3.517876e-04
## ASV4532      1.265705e-05  1.309381e-05  1.353964e-05  1.399436e-05
## ASV0274     -3.060479e-04 -3.190438e-04 -3.325243e-04 -3.465019e-04
## ASV0163     -4.407872e-04 -4.595857e-04 -4.790889e-04 -4.993148e-04
## ASV1298      1.803618e-04  1.880919e-04  1.961142e-04  2.044363e-04
## ASV9424     -3.866317e-04 -4.044078e-04 -4.229687e-04 -4.423461e-04
## ASV0412      5.873754e-04  6.135829e-04  6.408794e-04  6.693031e-04
## ASV0284      2.591864e-04  2.703185e-04  2.818732e-04  2.938619e-04
## ASV0620     -2.001871e-04 -2.096232e-04 -2.194947e-04 -2.298206e-04
## ASV0153     -4.087235e-04 -4.274709e-04 -4.470460e-04 -4.674826e-04
## ASV0498      4.965512e-05  5.262180e-05  5.577584e-05  5.912904e-05
## ASV0097      2.901444e-04  3.033832e-04  3.171996e-04  3.316164e-04
## ASV0104     -1.346676e-03 -1.406917e-03 -1.469681e-03 -1.535058e-03
## ASV1282      2.391925e-04  2.501999e-04  2.616928e-04  2.736904e-04
## ASV3883     -1.329119e-04 -1.388542e-04 -1.450415e-04 -1.514819e-04
## ASV0801      1.429726e-04  1.500079e-04  1.573944e-04  1.651496e-04
## ASV1611     -5.176100e-04 -5.409564e-04 -5.652944e-04 -5.906607e-04
## ASV0227     -1.841502e-04 -1.926101e-04 -2.014432e-04 -2.106646e-04
## ASV0833      2.055528e-04  2.153366e-04  2.255820e-04  2.363102e-04
## ASV0718      4.903555e-04  5.127484e-04  5.361201e-04  5.605096e-04
## ASV1139      1.827342e-04  1.907764e-04  1.991422e-04  2.078422e-04
## ASV0766     -1.294213e-04 -1.349825e-04 -1.407540e-04 -1.467413e-04
## ASV2091      6.403898e-04  6.680962e-04  6.968802e-04  7.267734e-04
## ASV1238     -3.011519e-05 -3.065859e-05 -3.115761e-05 -3.160539e-05
## ASV9193     -7.383082e-05 -7.808091e-05 -8.258562e-05 -8.735984e-05
## ASV0290     -5.009374e-05 -5.236539e-05 -5.473346e-05 -5.720134e-05
## ASV0231      5.076424e-04  5.300619e-04  5.533915e-04  5.776611e-04
## ASV0185      1.040761e-04  1.103956e-04  1.171292e-04  1.243047e-04
## ASV2330      1.474956e-04  1.539618e-04  1.606874e-04  1.676806e-04
## ASV3119     -1.735659e-04 -1.820392e-04 -1.909295e-04 -2.002571e-04
## ASV2368     -2.386791e-04 -2.498476e-04 -2.615269e-04 -2.737390e-04
## ASV0122     -1.858471e-04 -1.940377e-04 -2.025633e-04 -2.114357e-04
## ASV1044      3.296795e-04  3.454320e-04  3.619366e-04  3.792288e-04
## ASV0160     -4.478390e-04 -4.668811e-04 -4.866327e-04 -5.071120e-04
## ASV0326      2.940936e-04  3.073236e-04  3.211134e-04  3.354837e-04
## ASV1388      5.141002e-04  5.370578e-04  5.609726e-04  5.858787e-04
## ASV0792      5.895348e-04  6.158985e-04  6.433636e-04  6.719690e-04
## ASV0036     -3.748288e-04 -3.921773e-04 -4.103056e-04 -4.292467e-04
## ASV2125      6.056789e-04  6.329296e-04  6.613357e-04  6.909399e-04
## ASV1075      1.164616e-04  1.219160e-04  1.276234e-04  1.335952e-04
## ASV0390      1.222308e-04  1.285312e-04  1.351725e-04  1.421742e-04
## ASV3790     -4.732294e-04 -4.941128e-04 -5.158435e-04 -5.384494e-04
## ASV1535     -4.099625e-05 -4.300971e-05 -4.512010e-05 -4.733160e-05
## ASV0263      1.040538e-04  1.089255e-04  1.140201e-04  1.193471e-04
## ASV0675      8.081427e-04  8.456989e-04  8.849521e-04  9.259742e-04
## ASV3348      7.932490e-05  8.321437e-05  8.729854e-05  9.158734e-05
## ASV0058     -7.547377e-04 -7.881890e-04 -8.230144e-04 -8.592614e-04
## ASV4142      1.854230e-04  1.934477e-04  2.017850e-04  2.104440e-04
## ASV0059     -6.502566e-04 -6.790015e-04 -7.089207e-04 -7.400540e-04
## ASV0013     -1.364953e-03 -1.425903e-03 -1.489396e-03 -1.555523e-03
## ASV0033     -4.091278e-04 -4.281391e-04 -4.480115e-04 -4.687818e-04
## ASV4354     -1.751582e-04 -1.828329e-04 -1.908136e-04 -1.991099e-04
## ASV0022     -4.319374e-04 -4.519891e-04 -4.729471e-04 -4.948500e-04
## ASV0134     -1.112862e-04 -1.168174e-04 -1.226313e-04 -1.287428e-04
## ASV0415     -8.622878e-05 -8.955506e-05 -9.297505e-05 -9.648840e-05
## ASV10103    -2.978222e-04 -3.113359e-04 -3.254307e-04 -3.401289e-04
## ASV1613      4.834340e-04  5.050247e-04  5.275168e-04  5.509426e-04
## ASV0135     -2.813572e-05 -2.894883e-05 -2.975438e-05 -3.054821e-05
## ASV0469     -5.997591e-04 -6.262946e-04 -6.539138e-04 -6.826532e-04
## ASV0471      3.887391e-04  4.066107e-04  4.252705e-04  4.447498e-04
## ASV0451     -1.048943e-04 -1.099286e-04 -1.152065e-04 -1.207399e-04
## ASV0747      1.444749e-04  1.510892e-04  1.579919e-04  1.651940e-04
## ASV1314     -2.315041e-04 -2.424958e-04 -2.540040e-04 -2.660522e-04
## ASV0425     -6.752572e-04 -7.045872e-04 -7.350679e-04 -7.667341e-04
## ASV0559     -3.794568e-04 -3.956799e-04 -4.125156e-04 -4.299802e-04
## ASV0148     -4.151776e-04 -4.330719e-04 -4.516560e-04 -4.709495e-04
## ASV0129     -2.047385e-04 -2.131944e-04 -2.219446e-04 -2.309948e-04
## ASV1072      1.992082e-04  2.076489e-04  2.164032e-04  2.254793e-04
## ASV2390      1.456997e-04  1.520308e-04  1.586098e-04  1.654440e-04
## ASV0548      4.428096e-04  4.630524e-04  4.841838e-04  5.062397e-04
## ASV0168     -6.534228e-04 -6.821086e-04 -7.119484e-04 -7.429799e-04
## ASV0066     -4.921475e-04 -5.142158e-04 -5.372133e-04 -5.611741e-04
## ASV0468     -1.898296e-04 -1.987752e-04 -2.081367e-04 -2.179328e-04
## ASV0172     -9.910610e-05 -1.028432e-04 -1.066773e-04 -1.106071e-04
## ASV0236     -2.463354e-04 -2.562414e-04 -2.664651e-04 -2.770098e-04
## ASV0250      2.109034e-05  2.326577e-05  2.563918e-05  2.822666e-05
## ASV0338     -2.397040e-05 -2.402736e-05 -2.399966e-05 -2.387717e-05
## ASV0450      1.884299e-06  2.168669e-06  2.482828e-06  2.829432e-06
## ASV0377      5.418877e-04  5.663671e-04  5.918922e-04  6.185024e-04
## ASV1022      1.548040e-04  1.620283e-04  1.695822e-04  1.774802e-04
## ASV6174     -3.313851e-05 -3.437465e-05 -3.563884e-05 -3.692979e-05
## ASV0786      6.152919e-05  6.419564e-05  6.696510e-05  6.984042e-05
## ASV0053     -6.504178e-04 -6.798147e-04 -7.104697e-04 -7.424305e-04
## ASV0697     -1.855389e-04 -1.934659e-04 -2.016930e-04 -2.102283e-04
## ASV0785      4.833170e-04  5.051369e-04  5.278924e-04  5.516195e-04
## ASV1967     -3.212167e-04 -3.353543e-04 -3.500622e-04 -3.653590e-04
## ASV0385     -1.447294e-04 -1.507901e-04 -1.570723e-04 -1.635819e-04
## ASV0295      1.904308e-06  2.490682e-06  3.146450e-06  3.878063e-06
## ASV0072     -5.134290e-04 -5.358395e-04 -5.591414e-04 -5.833628e-04
## ASV0157     -2.062177e-04 -2.146197e-04 -2.232966e-04 -2.322511e-04
## ASV0501      2.417959e-04  2.532133e-04  2.651560e-04  2.776463e-04
## ASV10729    -3.987844e-04 -4.170140e-04 -4.360399e-04 -4.558934e-04
## ASV1470      1.741702e-04  1.812701e-04  1.886091e-04  1.961910e-04
## ASV0050     -1.286901e-03 -1.344016e-03 -1.403482e-03 -1.465380e-03
## ASV0411     -3.494043e-05 -3.639818e-05 -3.791140e-05 -3.948207e-05
## ASV0549      2.489915e-04  2.606867e-04  2.729249e-04  2.857308e-04
## ASV0184      1.530539e-04  1.600118e-04  1.672709e-04  1.748432e-04
## ASV0705      1.877384e-04  1.965865e-04  2.058440e-04  2.155288e-04
## ASV1715      4.596922e-04  4.804628e-04  5.021220e-04  5.247034e-04
## ASV0603      5.982190e-05  6.283723e-05  6.601019e-05  6.934938e-05
## ASV0826      1.523731e-04  1.589587e-04  1.657992e-04  1.729020e-04
## ASV0034     -5.844027e-04 -6.102567e-04 -6.371651e-04 -6.651631e-04
## ASV0838      1.403364e-04  1.473279e-04  1.546719e-04  1.623858e-04
## ASV0614     -3.401582e-04 -3.556380e-04 -3.717896e-04 -3.886396e-04
## ASV0014     -1.248581e-03 -1.304094e-03 -1.361902e-03 -1.422084e-03
## ASV0585     -7.145607e-05 -7.438880e-05 -7.742158e-05 -8.055611e-05
## ASV0016     -1.276963e-03 -1.333790e-03 -1.392971e-03 -1.454587e-03
## ASV5394     -3.302848e-04 -3.454449e-04 -3.612730e-04 -3.777961e-04
## ASV0666      2.779536e-04  2.904173e-04  3.034042e-04  3.169328e-04
## ASV2085      1.066065e-04  1.107426e-04  1.149963e-04  1.193668e-04
## ASV0003     -1.167424e-03 -1.219245e-03 -1.273202e-03 -1.329366e-03
## ASV0346     -1.716780e-05 -1.715111e-05 -1.706457e-05 -1.689973e-05
## ASV0267     -1.895362e-04 -1.978857e-04 -2.065730e-04 -2.156092e-04
## ASV0353      2.584623e-04  2.709658e-04  2.840717e-04  2.978080e-04
## ASV2419      3.312260e-04  3.459316e-04  3.612433e-04  3.771819e-04
## ASV0447      1.614452e-04  1.695107e-04  1.779881e-04  1.868983e-04
## ASV0654      5.112155e-04  5.343629e-04  5.585021e-04  5.836705e-04
## ASV0151      8.157401e-05  8.572332e-05  9.009299e-05  9.469533e-05
## ASV0065     -4.720418e-04 -4.931159e-04 -5.150707e-04 -5.379380e-04
## ASV0527      3.466297e-04  3.623402e-04  3.787268e-04  3.958156e-04
## ASV4055     -1.383376e-04 -1.452212e-04 -1.524572e-04 -1.600643e-04
## ASV0166     -3.802986e-04 -3.963763e-04 -4.130462e-04 -4.303226e-04
## ASV0417     -3.309910e-04 -3.455842e-04 -3.607691e-04 -3.765652e-04
## ASV0078     -2.644897e-04 -2.759955e-04 -2.879558e-04 -3.003847e-04
## ASV0322     -3.150153e-04 -3.283956e-04 -3.422753e-04 -3.566674e-04
## ASV0156     -4.080504e-04 -4.254892e-04 -4.435879e-04 -4.623645e-04
## ASV0648     -3.869138e-04 -4.047593e-04 -4.233985e-04 -4.428639e-04
## ASV0407      2.068143e-05  2.138179e-05  2.209251e-05  2.281240e-05
## ASV2030     -7.891595e-05 -8.210709e-05 -8.540107e-05 -8.879884e-05
## ASV0300      2.336165e-04  2.450030e-04  2.569477e-04  2.694776e-04
## ASV1150     -3.253992e-05 -3.400585e-05 -3.553359e-05 -3.712534e-05
## ASV0958      2.388439e-04  2.502970e-04  2.623000e-04  2.748792e-04
## ASV0216     -4.034685e-04 -4.212029e-04 -4.396496e-04 -4.588314e-04
## ASV0446      5.668248e-04  5.932979e-04  6.209770e-04  6.499139e-04
## ASV0367     -1.909759e-04 -1.994862e-04 -2.083500e-04 -2.175798e-04
## ASV0200     -3.498988e-04 -3.653561e-04 -3.814469e-04 -3.981932e-04
## ASV0334     -1.727107e-04 -1.792502e-04 -1.859580e-04 -1.928311e-04
## ASV1311      2.611778e-04  2.732419e-04  2.858467e-04  2.990150e-04
## ASV0458      2.728857e-04  2.851066e-04  2.978407e-04  3.111069e-04
## ASV1371      3.571739e-06  3.536804e-06  3.482451e-06  3.406319e-06
## ASV0418      3.188499e-04  3.325930e-04  3.468662e-04  3.616848e-04
## ASV0004      3.899220e-04  4.072084e-04  4.252050e-04  4.439359e-04
## ASV1943      2.855876e-04  2.980968e-04  3.111066e-04  3.246333e-04
## ASV1495     -7.279023e-05 -7.651322e-05 -8.043389e-05 -8.456303e-05
## ASV0901     -4.542847e-04 -4.752740e-04 -4.972033e-04 -5.201119e-04
## ASV0628      2.657135e-04  2.776045e-04  2.899945e-04  3.029015e-04
## ASV0400      1.038343e-04  1.083383e-04  1.130157e-04  1.178713e-04
## ASV0116     -3.374160e-04 -3.526086e-04 -3.684465e-04 -3.849537e-04
## ASV0788      2.837693e-04  2.964948e-04  3.097557e-04  3.235714e-04
## ASV0117      1.847618e-04  1.934519e-04  2.025452e-04  2.120597e-04
## ASV3137      5.077713e-05  5.305840e-05  5.543730e-05  5.791774e-05
## ASV0001      4.749460e-04  4.958999e-04  5.177073e-04  5.403970e-04
## ASV1651      3.012920e-04  3.138406e-04  3.268315e-04  3.402733e-04
## ASV1692      3.419523e-04  3.579351e-04  3.746488e-04  3.921250e-04
## ASV0660      1.911035e-04  1.991914e-04  2.075733e-04  2.162554e-04
## ASV0508      2.533160e-05  2.638541e-05  2.747579e-05  2.860331e-05
## ASV1660     -1.381544e-04 -1.445905e-04 -1.513175e-04 -1.583473e-04
## ASV0233      7.817455e-05  8.190288e-05  8.580978e-05  8.990390e-05
## ASV1343     -3.404049e-04 -3.558759e-04 -3.720156e-04 -3.888498e-04
## ASV0209      3.197124e-04  3.339546e-04  3.487895e-04  3.642382e-04
## ASV0193     -3.945904e-04 -4.113881e-04 -4.288160e-04 -4.468908e-04
## ASV0357     -3.059327e-05 -3.191726e-05 -3.329004e-05 -3.471241e-05
## ASV0198      9.254232e-05  9.696606e-05  1.015989e-04  1.064504e-04
## ASV0007      4.512299e-04  4.711843e-04  4.919557e-04  5.135724e-04
## ASV1772     -4.425218e-05 -4.613030e-05 -4.807741e-05 -5.009505e-05
## ASV0009      4.261419e-04  4.449810e-04  4.645912e-04  4.849991e-04
## ASV0006      1.694851e-04  1.765904e-04  1.839521e-04  1.915761e-04
## ASV0011     -4.769450e-04 -4.987623e-04 -5.215347e-04 -5.453000e-04
## ASV0015      3.289050e-04  3.435602e-04  3.588239e-04  3.747175e-04
## ASV0017      3.482247e-04  3.637156e-04  3.798478e-04  3.966439e-04
## ASV0235     -2.748621e-04 -2.872338e-04 -3.001271e-04 -3.135607e-04
## ASV0382      5.620156e-05  5.950041e-05  6.300536e-05  6.672954e-05
## ASV2357      4.190176e-04  4.378678e-04  4.575157e-04  4.779905e-04
## ASV0567     -3.059014e-04 -3.195259e-04 -3.337173e-04 -3.484959e-04
## ASV0165      3.375495e-04  3.528330e-04  3.687711e-04  3.853882e-04
## ASV0005      6.655995e-04  6.948465e-04  7.252709e-04  7.569110e-04
## ASV0384     -3.515528e-05 -3.660474e-05 -3.810395e-05 -3.965374e-05
## ASV0002      1.419429e-04  1.484411e-04  1.552242e-04  1.623034e-04
## ASV3017      3.898256e-04  4.069212e-04  4.247021e-04  4.431901e-04
## ASV0091      1.507692e-04  1.576563e-04  1.648432e-04  1.723416e-04
## ASV0186     -4.007172e-04 -4.186313e-04 -4.372929e-04 -4.567284e-04
## ASV0370      4.464285e-05  4.690114e-05  4.927903e-05  5.178327e-05
## ASV0018      6.936797e-04  7.242358e-04  7.560288e-04  7.890997e-04
## ASV1377      6.099521e-04  6.369237e-04  6.649943e-04  6.942005e-04
## ASV0019      6.946782e-04  7.252889e-04  7.571399e-04  7.902720e-04
## ASV0023      4.795071e-05  4.960300e-05  5.128193e-05  5.298492e-05
## ASV2194      2.249318e-04  2.350744e-04  2.456524e-04  2.566830e-04
## ASV1155     -1.961116e-05 -1.999429e-05 -2.034935e-05 -2.067145e-05
## ASV0510     -2.470542e-04 -2.571255e-04 -2.675340e-04 -2.782847e-04
## ASV2371     -2.509283e-04 -2.617003e-04 -2.728824e-04 -2.844857e-04
## ASV0024      1.426626e-05  1.440259e-05  1.450124e-05  1.455722e-05
## ASV2452      3.287247e-04  3.431048e-04  3.580587e-04  3.736046e-04
## ASV2332      6.095954e-06  6.372481e-06  6.663135e-06  6.968904e-06
## ASV2591      1.515945e-05  1.630619e-05  1.754249e-05  1.887513e-05
## ASV0521      4.635306e-04  4.853190e-04  5.081122e-04  5.319544e-04
## ASV5542      1.384668e-04  1.448765e-04  1.515733e-04  1.585694e-04
## ASV0336     -2.004297e-04 -2.089100e-04 -2.177037e-04 -2.268184e-04
## ASV10102     3.109415e-04  3.249890e-04  3.396351e-04  3.549021e-04
## ASV16823    -2.459238e-04 -2.565525e-04 -2.675926e-04 -2.790559e-04
## ASV3104      2.459010e-04  2.565277e-04  2.675656e-04  2.790267e-04
## ASV0781      1.233589e-04  1.290681e-04  1.350339e-04  1.412672e-04
## ASV10899     1.151201e-04  1.207508e-04  1.266601e-04  1.328617e-04
## ASV11222    -2.458861e-04 -2.565116e-04 -2.675482e-04 -2.790078e-04
## ASV11327    -2.458633e-04 -2.564868e-04 -2.675213e-04 -2.789785e-04
## ASV12458    -2.458406e-04 -2.564621e-04 -2.674944e-04 -2.789493e-04
## ASV1636     -1.986610e-04 -2.071127e-04 -2.158790e-04 -2.249679e-04
## ASV1890     -2.443605e-04 -2.549733e-04 -2.660018e-04 -2.774582e-04
## ASV2898      5.318561e-04  5.555980e-04  5.803284e-04  6.060822e-04
## ASV8328     -3.869250e-05 -3.980945e-05 -4.091832e-05 -4.201404e-05
## ASV0709     -4.303785e-04 -4.494478e-04 -4.692984e-04 -4.899568e-04
## ASV0856      7.324832e-05  7.692030e-05  8.078240e-05  8.484479e-05
## ASV0909     -1.772514e-04 -1.843651e-04 -1.917043e-04 -1.992709e-04
## ASV0937     -3.375761e-04 -3.528031e-04 -3.686786e-04 -3.852269e-04
## ASV11390    -2.457925e-04 -2.564099e-04 -2.674377e-04 -2.788878e-04
## ASV11966     1.217007e-04  1.272735e-04  1.330898e-04  1.391590e-04
## ASV12990     6.883681e-05  7.208100e-05  7.547582e-05  7.902800e-05
## ASV14797     2.550576e-04  2.663267e-04  2.780548e-04  2.902570e-04
## ASV14904    -2.457862e-04 -2.564031e-04 -2.674304e-04 -2.788799e-04
## ASV15304     6.304289e-05  6.605110e-05  6.920088e-05  7.249852e-05
## ASV16696    -2.457672e-04 -2.563824e-04 -2.674080e-04 -2.788556e-04
## ASV1690      1.273162e-04  1.334042e-04  1.397811e-04  1.464600e-04
## ASV2029      6.807479e-04  7.111768e-04  7.428758e-04  7.758899e-04
## ASV2834      3.604772e-04  3.765319e-04  3.932507e-04  4.106565e-04
## ASV4003      1.087754e-04  1.143553e-04  1.202343e-04  1.264289e-04
## ASV4064      2.484746e-04  2.595238e-04  2.710286e-04  2.830045e-04
## ASV4294      9.355181e-05  9.837537e-05  1.034598e-04  1.088198e-04
## ASV4609     -1.211425e-05 -1.261562e-05 -1.313350e-05 -1.366797e-05
## ASV6283     -2.457648e-04 -2.563801e-04 -2.674057e-04 -2.788535e-04
## ASV6491     -2.457421e-04 -2.563553e-04 -2.673788e-04 -2.788243e-04
## ASV7453      1.001033e-04  1.051042e-04  1.103602e-04  1.158841e-04
## ASV7959      1.832358e-05  1.947353e-05  2.070042e-05  2.200941e-05
## ASV8219      2.457264e-04  2.563384e-04  2.673605e-04  2.788046e-04
## ASV8547     -2.457037e-04 -2.563137e-04 -2.673337e-04 -2.787754e-04
## ASV9319      1.629486e-04  1.702762e-04  1.779127e-04  1.858695e-04
## ASV9382     -2.456895e-04 -2.562983e-04 -2.673170e-04 -2.787572e-04
## ASV11516    -2.456667e-04 -2.562736e-04 -2.672901e-04 -2.787280e-04
## ASV14377    -2.456440e-04 -2.562489e-04 -2.672632e-04 -2.786989e-04
## ASV1867      3.629077e-04  3.795343e-04  3.968921e-04  4.150103e-04
## ASV1895     -8.417493e-05 -8.779950e-05 -9.156379e-05 -9.547185e-05
## ASV3168      1.514115e-04  1.580310e-04  1.649132e-04  1.720662e-04
## ASV4449      3.062638e-04  3.196810e-04  3.336344e-04  3.481412e-04
## ASV6596      1.839117e-04  1.929668e-04  2.024778e-04  2.124682e-04
## ASV7492     -9.100506e-05 -9.459738e-05 -9.829753e-05 -1.021057e-04
## ASV9854     -1.254434e-04 -1.307258e-04 -1.361998e-04 -1.418697e-04
## ASV6296      2.455967e-04  2.561975e-04  2.672076e-04  2.786386e-04
## ASV4201      8.339265e-05  8.780893e-05  9.247174e-05  9.739541e-05
## ASV0552      6.086601e-04  6.366180e-04  6.658095e-04  6.962842e-04
## ASV3671     -4.661938e-05 -4.817618e-05 -4.975019e-05 -5.133773e-05
## ASV3529     -5.512660e-05 -5.720703e-05 -5.934083e-05 -6.152707e-05
## ASV1060      1.558375e-04  1.631561e-04  1.708142e-04  1.788272e-04
## ASV0239     -3.326478e-04 -3.466357e-04 -3.611290e-04 -3.761386e-04
## ASV5711     -3.137004e-04 -3.273345e-04 -3.415034e-04 -3.562233e-04
## ASV4152     -4.127393e-04 -4.308565e-04 -4.497004e-04 -4.692941e-04
## ASV1461      3.692956e-04  3.853362e-04  4.020055e-04  4.193222e-04
## ASV2877      2.997573e-04  3.129608e-04  3.266979e-04  3.409861e-04
## ASV0012      2.260182e-04  2.363647e-04  2.471644e-04  2.584354e-04
## ASV9823      6.802383e-05  7.033065e-05  7.267364e-05  7.504947e-05
## ASV0008      2.466502e-04  2.578673e-04  2.695698e-04  2.817762e-04
## ASV7832     -2.573847e-04 -2.687524e-04 -2.805824e-04 -2.928901e-04
## ASV1915      2.121152e-05  2.240343e-05  2.366602e-05  2.500350e-05
## ASV0055      1.768086e-04  1.847341e-04  1.929921e-04  2.015945e-04
## ASV0032      4.344675e-04  4.540179e-04  4.743979e-04  4.956386e-04
## ASV2977     -3.479616e-04 -3.632452e-04 -3.791426e-04 -3.956733e-04
## ASV0466      3.492394e-04  3.642394e-04  3.798114e-04  3.959708e-04
## ASV3866      3.782417e-04  3.955422e-04  4.136007e-04  4.324472e-04
## ASV0040      4.952809e-04  5.177130e-04  5.411067e-04  5.654985e-04
## ASV0496     -3.077577e-05 -3.272526e-05 -3.480798e-05 -3.703330e-05
## ASV0052      6.025607e-04  6.292432e-04  6.570173e-04  6.859200e-04
## ASV3828     -3.772188e-04 -3.940757e-04 -4.116378e-04 -4.299305e-04
## ASV1930      2.365186e-04  2.473258e-04  2.586039e-04  2.703713e-04
## ASV2126      3.805961e-04  3.977123e-04  4.155534e-04  4.341461e-04
## ASV0793      2.232673e-04  2.335187e-04  2.442238e-04  2.554012e-04
## ASV0299     -1.555773e-04 -1.619780e-04 -1.685951e-04 -1.754319e-04
## ASV0208      3.649762e-04  3.822476e-04  4.003264e-04  4.192492e-04
## ASV0511     -1.871806e-04 -1.948383e-04 -2.027524e-04 -2.109267e-04
## ASV1123     -2.461504e-04 -2.564527e-04 -2.671232e-04 -2.781695e-04
## ASV0099     -1.320206e-04 -1.375220e-04 -1.432172e-04 -1.491099e-04
## ASV0752     -3.079659e-05 -3.248863e-05 -3.428006e-05 -3.617705e-05
## ASV0883      1.869112e-06  1.998008e-06  2.136981e-06  2.286901e-06
## ASV0683      3.232138e-04  3.383889e-04  3.542649e-04  3.708728e-04
## ASV4117     -3.712380e-04 -3.874464e-04 -4.042968e-04 -4.218088e-04
## ASV2172      1.396209e-04  1.458993e-04  1.524442e-04  1.592657e-04
## ASV0330     -2.566154e-04 -2.683156e-04 -2.805282e-04 -2.932738e-04
## ASV0728      2.282164e-04  2.381307e-04  2.484355e-04  2.591429e-04
## ASV0499      4.889446e-04  5.119295e-04  5.359779e-04  5.611369e-04
## ASV0120     -5.277973e-04 -5.514014e-04 -5.759904e-04 -6.015991e-04
## ASV1446      4.294616e-05  4.451250e-05  4.611202e-05  4.774299e-05
## ASV17171    -3.587000e-04 -3.746957e-04 -3.913560e-04 -4.087043e-04
## ASV0533      1.039178e-04  1.088461e-04  1.140051e-04  1.194052e-04
## ASV2495     -1.439394e-04 -1.504563e-04 -1.572533e-04 -1.643411e-04
## ASV5582      1.227473e-04  1.278507e-04  1.331342e-04  1.386016e-04
## ASV1488      1.300470e-04  1.366506e-04  1.435945e-04  1.508958e-04
## ASV0682      3.410528e-04  3.570942e-04  3.738772e-04  3.914343e-04
## ASV0068     -1.985500e-05 -2.104284e-05 -2.230618e-05 -2.364985e-05
## ASV1987     -1.809329e-04 -1.895117e-04 -1.984929e-04 -2.078948e-04
## ASV0035      6.111423e-05  6.328276e-05  6.548978e-05  6.773182e-05
## ASV7192     -2.367356e-04 -2.468528e-04 -2.573504e-04 -2.682383e-04
## ASV0873      3.455454e-05  3.578331e-05  3.703609e-05  3.831148e-05
## ASV4749      2.095915e-05  2.145505e-05  2.193195e-05  2.238566e-05
## ASV2174      2.151588e-04  2.238930e-04  2.329200e-04  2.422448e-04
## ASV1476     -1.957095e-04 -2.043831e-04 -2.134128e-04 -2.228108e-04
## ASV0740     -4.888445e-04 -5.114743e-04 -5.351198e-04 -5.598236e-04
## ASV0170      1.035995e-04  1.082991e-04  1.132022e-04  1.183167e-04
## ASV2466     -4.431635e-04 -4.632017e-04 -4.840989e-04 -5.058879e-04
## ASV1709      3.400495e-04  3.551372e-04  3.708457e-04  3.871964e-04
## ASV6170     -2.853991e-04 -2.971817e-04 -3.093791e-04 -3.220008e-04
## ASV3673      3.447318e-04  3.598181e-04  3.755125e-04  3.918354e-04
## ASV1745      2.038299e-05  2.104513e-05  2.171684e-05  2.239737e-05
## ASV0380     -2.269439e-04 -2.361172e-04 -2.455972e-04 -2.553894e-04
## ASV0426     -6.818015e-05 -7.075475e-05 -7.339544e-05 -7.610099e-05
## ASV0202     -6.622592e-05 -6.815538e-05 -7.007317e-05 -7.197076e-05
## ASV6350     -2.874372e-04 -2.994880e-04 -3.119817e-04 -3.249301e-04
## ASV0713     -2.075373e-04 -2.167474e-04 -2.263386e-04 -2.363245e-04
## ASV1822      4.191307e-05  4.394127e-05  4.606417e-05  4.828555e-05
## ASV4569      3.350918e-04  3.498350e-04  3.651772e-04  3.811387e-04
## ASV0030     -7.641593e-05 -8.010906e-05 -8.397928e-05 -8.803465e-05
## ASV0331      1.424084e-04  1.493718e-04  1.566810e-04  1.643534e-04
## ASV2981      3.439432e-04  3.598500e-04  3.764655e-04  3.938185e-04
## ASV0828     -2.301592e-04 -2.409693e-04 -2.522759e-04 -2.641003e-04
## ASV2440      5.445496e-04  5.697766e-04  5.961357e-04  6.236740e-04
## ASV3006     -2.304065e-04 -2.397494e-04 -2.494076e-04 -2.593871e-04
## ASV3875     -2.303866e-04 -2.397280e-04 -2.493844e-04 -2.593621e-04
## ASV4511      1.377665e-04  1.443300e-04  1.512041e-04  1.584028e-04
## ASV4700     -2.303670e-04 -2.397067e-04 -2.493615e-04 -2.593372e-04
## ASV5804     -2.303472e-04 -2.396853e-04 -2.493383e-04 -2.593122e-04
## ASV6826      2.532586e-04  2.651837e-04  2.776623e-04  2.907190e-04
## ASV7280      2.086733e-04  2.183400e-04  2.284345e-04  2.389736e-04
## ASV7535     -2.303373e-04 -2.396747e-04 -2.493270e-04 -2.593002e-04
## ASV0651     -2.419251e-04 -2.524780e-04 -2.634469e-04 -2.748441e-04
## ASV0913      3.303991e-04  3.458242e-04  3.619553e-04  3.788234e-04
## ASV10832    -2.303185e-04 -2.396544e-04 -2.493050e-04 -2.592764e-04
## ASV1117     -4.638473e-04 -4.843378e-04 -5.056663e-04 -5.278615e-04
## ASV11329     1.188435e-04  1.251779e-04  1.318647e-04  1.389239e-04
## ASV13209    -1.077028e-05 -1.045556e-05 -1.006558e-05 -9.593342e-06
## ASV1345      5.790483e-05  6.066545e-05  6.355107e-05  6.656629e-05
## ASV1719     -2.302883e-04 -2.396218e-04 -2.492700e-04 -2.592388e-04
## ASV1886      2.680298e-04  2.799512e-04  2.923710e-04  3.053076e-04
## ASV2158     -6.074219e-05 -6.275258e-05 -6.479368e-05 -6.686309e-05
## ASV2189      2.880630e-04  3.011110e-04  3.147209e-04  3.289144e-04
## ASV2257      2.110736e-04  2.203389e-04  2.299800e-04  2.400098e-04
## ASV2283      2.302442e-04  2.395740e-04  2.492183e-04  2.591827e-04
## ASV2328      2.302244e-04  2.395526e-04  2.491951e-04  2.591577e-04
## ASV2434     -3.443189e-04 -3.591938e-04 -3.746519e-04 -3.907117e-04
## ASV2648      2.301810e-04  2.395056e-04  2.491441e-04  2.591025e-04
## ASV2698      3.388063e-04  3.543233e-04  3.705246e-04  3.874385e-04
## ASV2775      3.993596e-04  4.163615e-04  4.340021e-04  4.522986e-04
## ASV3171      2.301396e-04  2.394607e-04  2.490954e-04  2.590497e-04
## ASV3227      2.941649e-04  3.065198e-04  3.193237e-04  3.325870e-04
## ASV3397      1.833585e-05  1.922638e-05  2.015544e-05  2.112389e-05
## ASV3444      3.324480e-04  3.466525e-04  3.614009e-04  3.767093e-04
## ASV3556      2.300879e-04  2.394047e-04  2.490348e-04  2.589841e-04
## ASV3606     -2.300682e-04 -2.393833e-04 -2.490117e-04 -2.589591e-04
## ASV4190      2.968856e-04  3.103139e-04  3.243192e-04  3.389238e-04
## ASV4197      3.388615e-04  3.531934e-04  3.680576e-04  3.834679e-04
## ASV4722      3.081434e-04  3.217987e-04  3.360155e-04  3.508135e-04
## ASV4765      7.904696e-05  8.283041e-05  8.678946e-05  9.093133e-05
## ASV4809      2.300191e-04  2.393301e-04  2.489540e-04  2.588967e-04
## ASV4846      2.207164e-04  2.308289e-04  2.413834e-04  2.523969e-04
## ASV4903     -5.724870e-05 -5.895465e-05 -6.066501e-05 -6.237525e-05
## ASV4944     -2.299999e-04 -2.393095e-04 -2.489319e-04 -2.588730e-04
## ASV5151     -9.071453e-05 -9.549381e-05 -1.005311e-04 -1.058398e-04
## ASV5413     -2.299856e-04 -2.392941e-04 -2.489154e-04 -2.588553e-04
## ASV5537     -2.299659e-04 -2.392728e-04 -2.488924e-04 -2.588304e-04
## ASV5688      2.299461e-04  2.392514e-04  2.488693e-04  2.588055e-04
## ASV5752      1.115331e-04  1.168005e-04  1.223068e-04  1.280614e-04
## ASV6122     -2.299316e-04 -2.392358e-04 -2.488524e-04 -2.587873e-04
## ASV6135      2.299118e-04  2.392144e-04  2.488293e-04  2.587624e-04
## ASV6188     -2.298921e-04 -2.391931e-04 -2.488063e-04 -2.587375e-04
## ASV6216      3.424734e-04  3.571425e-04  3.723746e-04  3.881863e-04
## ASV6242      2.298501e-04  2.391475e-04  2.487569e-04  2.586840e-04
## ASV6383      2.298303e-04  2.391262e-04  2.487339e-04  2.586591e-04
## ASV6781      2.298106e-04  2.391049e-04  2.487108e-04  2.586342e-04
## ASV6799     -2.297909e-04 -2.390835e-04 -2.486878e-04 -2.586093e-04
## ASV7374     -2.297712e-04 -2.390622e-04 -2.486647e-04 -2.585845e-04
## ASV7539     -2.297515e-04 -2.390409e-04 -2.486417e-04 -2.585596e-04
## ASV8591     -2.297318e-04 -2.390196e-04 -2.486187e-04 -2.585347e-04
## ASV8637      2.297120e-04  2.389983e-04  2.485956e-04  2.585098e-04
## ASV12796    -2.296923e-04 -2.389770e-04 -2.485726e-04 -2.584850e-04
## ASV1934      2.701629e-04  2.825076e-04  2.953927e-04  3.088398e-04
## ASV22549     1.800037e-05  1.963998e-05  2.141452e-05  2.333361e-05
## ASV29857    -2.296738e-04 -2.389570e-04 -2.485511e-04 -2.584619e-04
## ASV3215      3.291888e-04  3.444312e-04  3.603591e-04  3.770014e-04
## ASV3236     -2.296527e-04 -2.389342e-04 -2.485265e-04 -2.584353e-04
## ASV3954     -2.296330e-04 -2.389129e-04 -2.485035e-04 -2.584104e-04
## ASV4850      2.296133e-04  2.388916e-04  2.484805e-04  2.583856e-04
## ASV5225      2.295936e-04  2.388703e-04  2.484575e-04  2.583607e-04
## ASV5532     -2.295740e-04 -2.388490e-04 -2.484345e-04 -2.583359e-04
## ASV7258      3.264265e-05  3.524866e-05  3.805994e-05  4.109157e-05
## ASV9474     -1.297702e-04 -1.346385e-04 -1.396377e-04 -1.447676e-04
## ASV11857    -2.295482e-04 -2.388214e-04 -2.484049e-04 -2.583042e-04
## ASV1202     -2.295285e-04 -2.388001e-04 -2.483819e-04 -2.582794e-04
## ASV14742     1.682582e-04  1.765810e-04  1.853203e-04  1.944965e-04
## ASV16652     8.518832e-05  8.931680e-05  9.364018e-05  9.816660e-05
## ASV2019      3.394897e-04  3.541893e-04  3.694661e-04  3.853382e-04
## ASV2410     -3.172931e-04 -3.314733e-04 -3.462489e-04 -3.616422e-04
## ASV2718      3.408990e-04  3.568937e-04  3.736205e-04  3.911105e-04
## ASV2738      3.794561e-04  3.955116e-04  4.121619e-04  4.294221e-04
## ASV2876      2.294855e-04  2.387537e-04  2.483318e-04  2.582253e-04
## ASV3177      2.294659e-04  2.387324e-04  2.483088e-04  2.582005e-04
## ASV4367      2.294462e-04  2.387112e-04  2.482858e-04  2.581757e-04
## ASV4635      8.322170e-05  8.789505e-05  9.283980e-05  9.807119e-05
## ASV4896      2.412192e-05  2.640136e-05  2.887737e-05  3.156520e-05
## ASV4907      1.741010e-04  1.828178e-04  1.919771e-04  2.016007e-04
## ASV5230     -2.294471e-04 -2.387126e-04 -2.482880e-04 -2.581787e-04
## ASV6509     -2.294274e-04 -2.386914e-04 -2.482650e-04 -2.581539e-04
## ASV7376     -2.294077e-04 -2.386701e-04 -2.482420e-04 -2.581291e-04
## ASV8163     -2.293881e-04 -2.386489e-04 -2.482191e-04 -2.581043e-04
## ASV8195     -2.293684e-04 -2.386276e-04 -2.481961e-04 -2.580795e-04
## ASV8923      1.442144e-04  1.512258e-04  1.585754e-04  1.662784e-04
## ASV9666     -2.029804e-04 -2.110418e-04 -2.193609e-04 -2.279412e-04
## ASV1482      2.105848e-04  2.201365e-04  2.300965e-04  2.404795e-04
## ASV2726      2.792703e-04  2.923066e-04  3.059330e-04  3.201741e-04
## ASV3281     -2.293478e-04 -2.386055e-04 -2.481725e-04 -2.580543e-04
## ASV4235     -2.293281e-04 -2.385843e-04 -2.481495e-04 -2.580295e-04
## ASV4808      3.411074e-04  3.556612e-04  3.707678e-04  3.864426e-04
## ASV4861     -3.437191e-04 -3.585432e-04 -3.739469e-04 -3.899484e-04
## ASV5276      3.363173e-04  3.506001e-04  3.654181e-04  3.807857e-04
## ASV5837      2.957400e-04  3.094019e-04  3.236773e-04  3.385922e-04
## ASV7098      3.023087e-04  3.162273e-04  3.307673e-04  3.459547e-04
## ASV8451     -2.292370e-04 -2.384853e-04 -2.480421e-04 -2.579130e-04
## ASV8694     -2.292174e-04 -2.384641e-04 -2.480192e-04 -2.578882e-04
## ASV0905     -1.246042e-04 -1.303472e-04 -1.363393e-04 -1.425897e-04
## ASV2900      2.825392e-04  2.942833e-04  3.064498e-04  3.190490e-04
## ASV3963     -2.227559e-04 -2.317069e-04 -2.409533e-04 -2.505002e-04
## ASV0041     -2.535717e-04 -2.652582e-04 -2.774620e-04 -2.902038e-04
## ASV1865      2.612276e-04  2.738744e-04  2.871306e-04  3.010242e-04
## ASV1140      2.070061e-04  2.164846e-04  2.263728e-04  2.366859e-04
## ASV1179      3.057770e-04  3.198570e-04  3.345612e-04  3.499149e-04
## ASV0279      4.280213e-04  4.470098e-04  4.667842e-04  4.873725e-04
## ASV0043     -4.193883e-05 -4.449866e-05 -4.722852e-05 -5.014026e-05
## ASV2097     -2.387714e-04 -2.490360e-04 -2.597005e-04 -2.707776e-04
## ASV0309     -1.183511e-04 -1.233537e-04 -1.285432e-04 -1.339246e-04
## ASV0607      5.268438e-04  5.512485e-04  5.767498e-04  6.033938e-04
## ASV0025     -5.512709e-04 -5.766548e-04 -6.031626e-04 -6.308396e-04
## ASV2284     -8.357272e-05 -8.647226e-05 -8.942510e-05 -9.242804e-05
## ASV0556      9.557004e-05  1.004150e-04  1.055103e-04  1.108689e-04
## ASV5040      1.917354e-04  1.992825e-04  2.070647e-04  2.150849e-04
## ASV2924     -2.053404e-04 -2.135197e-04 -2.219627e-04 -2.306735e-04
## ASV1331      6.645774e-04  6.942620e-04  7.251878e-04  7.573994e-04
## ASV0506     -3.001568e-04 -3.128092e-04 -3.259254e-04 -3.395167e-04
## ASV1514      5.027962e-04  5.255499e-04  5.492775e-04  5.740155e-04
## ASV2144      4.150570e-04  4.333090e-04  4.522974e-04  4.720463e-04
## ASV2265      5.571163e-04  5.820948e-04  6.081235e-04  6.352404e-04
## ASV5156      1.167153e-04  1.211776e-04  1.257646e-04  1.304761e-04
## ASV5534      9.331636e-05  9.663039e-05  1.000125e-04  1.034598e-04
## ASV5747     -2.327453e-05 -2.530080e-05 -2.749253e-05 -2.986180e-05
## ASV6657      2.474785e-04  2.579738e-04  2.688606e-04  2.801493e-04
## ASV0658     -2.818163e-04 -2.937493e-04 -3.061257e-04 -3.189570e-04
## ASV0716      6.765309e-05  7.036893e-05  7.317110e-05  7.606039e-05
## ASV1657      1.180257e-04  1.225022e-04  1.271004e-04  1.318199e-04
## ASV1885     -1.051684e-05 -1.186958e-05 -1.335091e-05 -1.497090e-05
## ASV2333      6.125267e-04  6.395775e-04  6.677331e-04  6.970311e-04
## ASV3375      2.234613e-04  2.327692e-04  2.424110e-04  2.523945e-04
## ASV4317      2.407631e-04  2.517178e-04  2.631515e-04  2.750836e-04
## ASV9599     -2.334863e-05 -2.538101e-05 -2.757930e-05 -2.995561e-05
## ASV0175     -8.189482e-04 -8.548509e-04 -8.921895e-04 -9.310096e-04
## ASV1032      2.408363e-04  2.508691e-04  2.612607e-04  2.720192e-04
## ASV1235      2.972703e-06  2.432226e-06  1.813406e-06  1.109121e-06
## ASV1262      7.235390e-04  7.555469e-04  7.888625e-04  8.235298e-04
## ASV1320      1.832081e-04  1.923163e-04  2.018850e-04  2.119377e-04
## ASV13797     2.679655e-04  2.796315e-04  2.917623e-04  3.043730e-04
## ASV1491      1.404063e-04  1.474508e-04  1.548511e-04  1.626244e-04
## ASV15014    -2.337749e-05 -2.541191e-05 -2.761234e-05 -2.999090e-05
## ASV1510      2.253580e-04  2.362008e-04  2.475592e-04  2.594564e-04
## ASV1551     -8.803029e-05 -9.177640e-05 -9.566214e-05 -9.969099e-05
## ASV1919     -8.512447e-06 -7.886298e-06 -7.151221e-06 -6.296949e-06
## ASV2114      1.300233e-04  1.353163e-04  1.407911e-04  1.464516e-04
## ASV21486    -2.336392e-05 -2.539657e-05 -2.759500e-05 -2.997131e-05
## ASV2448      3.655663e-04  3.812156e-04  3.974602e-04  4.143164e-04
## ASV2589      1.740204e-04  1.812659e-04  1.887712e-04  1.965422e-04
## ASV2608      2.959435e-04  3.089505e-04  3.224851e-04  3.365652e-04
## ASV2786      2.410090e-04  2.518984e-04  2.632597e-04  2.751121e-04
## ASV2827      3.059929e-04  3.192736e-04  3.330749e-04  3.474126e-04
## ASV2872      2.473998e-04  2.576365e-04  2.682310e-04  2.791906e-04
## ASV3125      2.969475e-04  3.095543e-04  3.226339e-04  3.361993e-04
## ASV3247      3.215517e-04  3.351805e-04  3.493158e-04  3.639708e-04
## ASV3451     -2.347374e-05 -2.551582e-05 -2.772446e-05 -3.011179e-05
## ASV3465     -4.538125e-05 -4.847620e-05 -5.178941e-05 -5.533571e-05
## ASV3809      1.867506e-04  1.945115e-04  2.025487e-04  2.108681e-04
## ASV4006      3.982285e-04  4.149583e-04  4.322943e-04  4.502503e-04
## ASV4046      2.865397e-04  2.986982e-04  3.113118e-04  3.243929e-04
## ASV4938     -2.536786e-05 -2.749834e-05 -2.979933e-05 -3.228316e-05
## ASV5435     -2.350435e-05 -2.554847e-05 -2.775923e-05 -3.014877e-05
## ASV5605      1.122238e-04  1.162866e-04  1.204397e-04  1.246799e-04
## ASV5635     -2.350765e-05 -2.555175e-05 -2.776245e-05 -3.015187e-05
## ASV5743      3.626525e-04  3.783393e-04  3.946402e-04  4.115741e-04
## ASV6627     -2.352589e-05 -2.557143e-05 -2.778364e-05 -3.017469e-05
## ASV6785     -2.352167e-05 -2.556664e-05 -2.777823e-05 -3.016856e-05
## ASV7368      4.029291e-04  4.212488e-04  4.403666e-04  4.603146e-04
## ASV9118      1.061566e-04  1.100639e-04  1.140656e-04  1.181596e-04
## ASV9135      8.181717e-05  8.452614e-05  8.727011e-05  9.004428e-05
## ASV9435      1.860624e-04  1.933549e-04  2.008656e-04  2.085953e-04
## ASV9671     -2.355423e-05 -2.560164e-05 -2.781580e-05 -3.020886e-05
## ASV0387     -4.008407e-04 -4.178914e-04 -4.355811e-04 -4.539266e-04
## ASV0454     -3.995559e-04 -4.167674e-04 -4.346422e-04 -4.531995e-04
## ASV0751     -2.612084e-04 -2.722315e-04 -2.836604e-04 -2.955049e-04
## ASV1081      1.067848e-04  1.115417e-04  1.164941e-04  1.216484e-04
## ASV1332      2.192752e-04  2.289062e-04  2.389243e-04  2.493420e-04
## ASV2659      3.507445e-04  3.666108e-04  3.831520e-04  4.003929e-04
## ASV2979      3.600826e-04  3.752198e-04  3.909077e-04  4.071594e-04
## ASV4184      1.429688e-04  1.482411e-04  1.536400e-04  1.591627e-04
## ASV6198      1.265890e-04  1.318490e-04  1.372978e-04  1.429399e-04
## ASV7454      2.355186e-04  2.454974e-04  2.558469e-04  2.665768e-04
## ASV8198      9.169784e-05  9.478786e-05  9.792359e-05  1.011002e-04
## ASV0855      5.329219e-04  5.570160e-04  5.821431e-04  6.083425e-04
## ASV10092     2.230750e-04  2.325491e-04  2.423801e-04  2.525779e-04
## ASV1532      2.917248e-04  3.052899e-04  3.194688e-04  3.342877e-04
## ASV2553      7.004738e-04  7.317683e-04  7.643703e-04  7.983268e-04
## ASV2741      2.836378e-04  2.968808e-04  3.107226e-04  3.251880e-04
## ASV4095      1.552802e-04  1.629440e-04  1.709853e-04  1.794218e-04
## ASV5295      2.033668e-04  2.115318e-04  2.199612e-04  2.286583e-04
## ASV5787     -2.363019e-05 -2.568335e-05 -2.790363e-05 -3.030318e-05
## ASV9455      2.713283e-04  2.829274e-04  2.949694e-04  3.074674e-04
## ASV10879     2.846054e-04  2.971969e-04  3.103080e-04  3.239575e-04
## ASV3997      2.011267e-04  2.107512e-04  2.208293e-04  2.313812e-04
## ASV6760      5.248619e-05  5.377637e-05  5.503389e-05  5.625095e-05
## ASV6990      2.042249e-04  2.127947e-04  2.216787e-04  2.308852e-04
## ASV9560      1.253321e-04  1.302856e-04  1.353948e-04  1.406613e-04
## ASV0220      1.124628e-04  1.173737e-04  1.224777e-04  1.277802e-04
## ASV2518      2.753644e-04  2.877880e-04  3.007417e-04  3.142454e-04
## ASV3615      4.318507e-04  4.508803e-04  4.706837e-04  4.912871e-04
## ASV0075      9.182317e-05  9.536114e-05  9.899645e-05  1.027282e-04
## ASV8070      4.891296e-05  5.015214e-05  5.136563e-05  5.254660e-05
## ASV1658      2.033041e-04  2.119402e-04  2.209005e-04  2.301936e-04
## ASV0773      3.282058e-04  3.420900e-04  3.564875e-04  3.714111e-04
## ASV0799      1.054948e-05  1.100122e-05  1.146986e-05  1.195577e-05
## ASV1839     -6.326906e-05 -6.552197e-05 -6.781597e-05 -7.014763e-05
## ASV0265      3.219856e-04  3.372421e-04  3.532098e-04  3.699201e-04
## ASV3741      1.283691e-04  1.340493e-04  1.399616e-04  1.461141e-04
## ASV0847      4.465803e-04  4.664138e-04  4.870636e-04  5.085577e-04
## ASV1026      4.762467e-04  4.971925e-04  5.189818e-04  5.416420e-04
## ASV1222     -1.482640e-04 -1.540862e-04 -1.600866e-04 -1.662667e-04
## ASV0729      6.491319e-05  6.772644e-05  7.064902e-05  7.368406e-05
## ASV0143     -3.595960e-04 -3.747548e-04 -3.904680e-04 -4.067488e-04
## ASV1328      9.179215e-05  9.554686e-05  9.942989e-05  1.034436e-04
## ASV9078     -9.812415e-05 -1.036167e-04 -1.094298e-04 -1.155820e-04
## ASV0027     -5.245595e-04 -5.485647e-04 -5.736192e-04 -5.997641e-04
## ASV0546     -2.262817e-04 -2.358334e-04 -2.457370e-04 -2.560013e-04
## ASV1136      5.810917e-04  6.067675e-04  6.334939e-04  6.613073e-04
## ASV3081      2.783298e-04  2.908790e-04  3.039669e-04  3.176146e-04
## ASV0531      1.245379e-04  1.304326e-04  1.365991e-04  1.430486e-04
## ASV2525      1.581078e-04  1.648313e-04  1.718073e-04  1.790427e-04
## ASV1083     -5.857512e-05 -6.069173e-05 -6.285762e-05 -6.507183e-05
## ASV0424      1.040444e-04  1.087865e-04  1.137367e-04  1.189037e-04
## ASV0644      1.622399e-05  1.761845e-05  1.912433e-05  2.074944e-05
## ASV6007     -2.383838e-05 -2.591340e-05 -2.815787e-05 -3.058417e-05
## ASV0564      1.453691e-04  1.524172e-04  1.598048e-04  1.675475e-04
## ASV1938      1.524280e-04  1.586134e-04  1.650071e-04  1.716127e-04
## ASV6516     -3.547802e-04 -3.705296e-04 -3.869271e-04 -4.039949e-04
## ASV0503     -4.123776e-04 -4.296904e-04 -4.476297e-04 -4.662097e-04
## ASV6913     -4.097268e-04 -4.269327e-04 -4.447662e-04 -4.632427e-04
## ASV0164     -3.326829e-04 -3.482560e-04 -3.645436e-04 -3.815770e-04
## ASV1576      3.943784e-04  4.119147e-04  4.301797e-04  4.491994e-04
## ASV1725      1.940020e-04  2.033745e-04  2.131957e-04  2.234863e-04
## ASV4501      1.642759e-04  1.708519e-04  1.776393e-04  1.846409e-04
## ASV10678    -3.454619e-04 -3.606129e-04 -3.763708e-04 -3.927548e-04
## ASV0944      2.908390e-04  3.044403e-04  3.186630e-04  3.335339e-04
## ASV2292      4.483771e-04  4.680356e-04  4.884828e-04  5.097444e-04
## ASV1090      2.949674e-04  3.082273e-04  3.220502e-04  3.364572e-04
## ASV9117     -1.408261e-04 -1.463929e-04 -1.521342e-04 -1.580521e-04
## ASV0285     -1.772068e-04 -1.860125e-04 -1.952605e-04 -2.049726e-04
## ASV0463     -2.854383e-04 -2.976438e-04 -3.103110e-04 -3.234526e-04
## ASV3199      2.453357e-04  2.556113e-04  2.662595e-04  2.772894e-04
## ASV0150     -1.033761e-04 -1.084856e-04 -1.138498e-04 -1.194810e-04
## ASV6583     -1.453121e-04 -1.513117e-04 -1.575251e-04 -1.639576e-04
## ASV0392      2.363688e-04  2.470959e-04  2.582868e-04  2.699597e-04
## ASV14007    -2.843250e-04 -2.968283e-04 -3.098357e-04 -3.233636e-04
## ASV0177     -1.555384e-04 -1.620462e-04 -1.687890e-04 -1.757723e-04
## ASV6448     -1.261374e-04 -1.328268e-04 -1.398817e-04 -1.473218e-04
## ASV5399     -5.446451e-05 -5.791419e-05 -6.159135e-05 -6.551049e-05
## ASV0277     -5.914881e-05 -6.189185e-05 -6.475780e-05 -6.775167e-05
## ASV2599      9.271181e-05  9.562009e-05  9.854836e-05  1.014895e-04
## ASV13465    -7.344255e-05 -7.551860e-05 -7.758155e-05 -7.962317e-05
## ASV2412      1.479153e-04  1.546086e-04  1.615884e-04  1.688655e-04
## ASV0423      2.954526e-04  3.096904e-04  3.246181e-04  3.402691e-04
## ASV5187      1.767254e-04  1.837398e-04  1.909769e-04  1.984395e-04
## ASV0701     -6.795908e-04 -7.100973e-04 -7.418870e-04 -7.750061e-04
## ASV4248      1.647239e-04  1.726553e-04  1.809632e-04  1.896643e-04
## ASV0519      2.876335e-04  3.009991e-04  3.149652e-04  3.295567e-04
## ASV0764      5.102503e-05  5.378182e-05  5.669440e-05  5.977166e-05
## ASV5385     -3.581686e-04 -3.744006e-04 -3.913298e-04 -4.089827e-04
## ASV3021     -1.960424e-04 -2.035953e-04 -2.113659e-04 -2.193546e-04
## ASV4119     -1.086542e-04 -1.126939e-04 -1.168356e-04 -1.210778e-04
## ASV2534      5.768499e-05  6.014216e-05  6.269377e-05  6.534276e-05
## ASV1061      2.808804e-04  2.948960e-04  3.096288e-04  3.251161e-04
## ASV0670      3.818803e-04  3.991962e-04  4.172567e-04  4.360903e-04
## ASV1384      1.689575e-04  1.773288e-04  1.861187e-04  1.953476e-04
## ASV1981      3.566285e-04  3.729977e-04  3.900858e-04  4.079211e-04
## ASV9632     -1.125099e-04 -1.165129e-04 -1.206011e-04 -1.247715e-04
## ASV4564      8.812772e-05  9.222398e-05  9.650440e-05  1.009765e-04
## ASV5289     -7.913321e-05 -8.267561e-05 -8.636612e-05 -9.021001e-05
## ASV0516      7.232294e-04  7.558939e-04  7.899506e-04  8.254515e-04
## ASV1463     -2.580885e-04 -2.692004e-04 -2.807381e-04 -2.927131e-04
## ASV0969      1.194371e-04  1.244574e-04  1.296582e-04  1.350433e-04
## ASV1113     -3.368920e-04 -3.521050e-04 -3.679683e-04 -3.845067e-04
## ASV1234     -1.652310e-05 -1.818811e-05 -2.000495e-05 -2.198616e-05
## ASV3814      4.561291e-05  4.655020e-05  4.743685e-05  4.826420e-05
## ASV1000      3.420029e-04  3.569434e-04  3.724766e-04  3.886211e-04
## ASV0079     -3.326592e-05 -3.534825e-05 -3.757075e-05 -3.994310e-05
## ASV0145      1.144128e-04  1.190589e-04  1.238612e-04  1.288226e-04
## ASV0457     -4.297652e-04 -4.483455e-04 -4.676479e-04 -4.876935e-04
## ASV1485      1.424821e-04  1.491652e-04  1.561569e-04  1.634710e-04
## ASV0535     -9.458121e-05 -9.865062e-05 -1.028808e-04 -1.072773e-04
## ASV0259     -2.825791e-04 -2.950555e-04 -3.080358e-04 -3.215361e-04
## ASV0570      2.345542e-05  2.503417e-05  2.672407e-05  2.853277e-05
## ASV0906      3.666895e-04  3.827276e-04  3.994046e-04  4.167409e-04
## ASV1748     -2.222460e-04 -2.332352e-04 -2.447715e-04 -2.568813e-04
## ASV5520     -1.339450e-04 -1.410706e-04 -1.485895e-04 -1.565234e-04
## ASV2288     -4.180091e-04 -4.357828e-04 -4.542206e-04 -4.733397e-04
## ASV1887     -8.418435e-05 -8.882873e-05 -9.373816e-05 -9.892740e-05
## ASV0374     -1.321799e-04 -1.376920e-04 -1.434005e-04 -1.493096e-04
## ASV0823      4.127542e-04  4.305274e-04  4.489871e-04  4.681534e-04
## ASV0717      2.101832e-04  2.197981e-04  2.298345e-04  2.403091e-04
## ASV0431      1.429580e-04  1.490598e-04  1.553909e-04  1.619572e-04
## ASV1030      6.107868e-04  6.392766e-04  6.690599e-04  7.001917e-04
## ASV1082     -8.866059e-05 -9.266516e-05 -9.684010e-05 -1.011916e-04
## ASV2684      5.970753e-05  6.316865e-05  6.683752e-05  7.072612e-05
## ASV0051      5.411980e-04  5.661016e-04  5.921114e-04  6.192727e-04
## ASV0513      2.333499e-05  2.453172e-05  2.579237e-05  2.712049e-05
## ASV0581      6.844217e-04  7.154424e-04  7.477956e-04  7.815318e-04
## ASV7282      1.236421e-04  1.300584e-04  1.368235e-04  1.439572e-04
## ASV3009     -3.747646e-04 -3.916469e-04 -4.092451e-04 -4.275858e-04
## ASV2106     -1.873394e-04 -1.951393e-04 -2.032178e-04 -2.115811e-04
## ASV1012      1.224728e-04  1.284923e-04  1.348097e-04  1.414392e-04
## ASV0921     -7.192927e-06 -7.334583e-06 -7.465997e-06 -7.585362e-06
## ASV0010     -5.372451e-04 -5.620370e-04 -5.879317e-04 -6.149743e-04
## ASV1178      1.213248e-05  1.290810e-05  1.373384e-05  1.461267e-05
## ASV2848     -2.853668e-04 -2.977856e-04 -3.106979e-04 -3.241197e-04
## ASV0586      7.769753e-04  8.123395e-04  8.492367e-04  8.877265e-04
## ASV4225      2.510813e-05  2.669080e-05  2.837141e-05  3.015512e-05
## ASV2156     -3.236729e-04 -3.383629e-04 -3.536869e-04 -3.696693e-04
## ASV9778     -2.030002e-04 -2.119733e-04 -2.213116e-04 -2.310272e-04
## ASV0493     -4.487606e-04 -4.684457e-04 -4.889226e-04 -5.102173e-04
## ASV3770      8.111175e-05  8.439847e-05  8.779820e-05  9.131359e-05
## ASV0470      5.505886e-04  5.754060e-04  6.012797e-04  6.282490e-04
## ASV0262     -2.339920e-04 -2.455407e-04 -2.576658e-04 -2.703955e-04
## ASV0998      3.385876e-04  3.540582e-04  3.702058e-04  3.870574e-04
## ASV7708     -9.141477e-05 -9.535656e-05 -9.945011e-05 -1.036997e-04
## ASV0453     -1.141553e-05 -1.189279e-05 -1.238988e-05 -1.290786e-05
## ASV0044      6.944381e-04  7.258926e-04  7.586994e-04  7.929103e-04
## ASV5490      1.076294e-04  1.122120e-04  1.169642e-04  1.218897e-04
## ASV2638      3.056667e-05  3.213523e-05  3.378278e-05  3.551274e-05
## ASV0829     -5.967557e-05 -6.184781e-05 -6.407174e-05 -6.634643e-05
## ASV0601      1.294379e-04  1.356607e-04  1.421836e-04  1.490207e-04
## ASV0234      3.007088e-04  3.141530e-04  3.281588e-04  3.427461e-04
## ASV0133      3.988880e-04  4.170369e-04  4.359737e-04  4.557290e-04
## ASV0323      4.253112e-04  4.451754e-04  4.659489e-04  4.876717e-04
## ASV0854     -3.084166e-05 -3.194908e-05 -3.307773e-05 -3.422604e-05
## ASV0110      5.367064e-04  5.614385e-04  5.872710e-04  6.142490e-04
## ASV0816      2.860478e-05  2.981271e-05  3.106630e-05  3.236698e-05
## ASV1031     -8.287405e-05 -8.641820e-05 -9.010082e-05 -9.392664e-05
## ASV0144     -2.173951e-04 -2.271015e-04 -2.372126e-04 -2.477425e-04
## ASV0020     -1.031328e-04 -1.085737e-04 -1.143197e-04 -1.203888e-04
## ASV0962     -1.781467e-04 -1.861472e-04 -1.944845e-04 -2.031706e-04
## ASV0794      3.561408e-04  3.731749e-04  3.910163e-04  4.097017e-04
## ASV7117     -1.821595e-04 -1.904748e-04 -1.991549e-04 -2.082146e-04
## ASV1008     -1.312111e-04 -1.374837e-04 -1.440554e-04 -1.509405e-04
## ASV0096      5.782066e-04  6.048752e-04  6.327326e-04  6.618279e-04
## ASV0128     -3.488666e-04 -3.655777e-04 -3.830900e-04 -4.014418e-04
## ASV5232      2.623640e-04  2.745067e-04  2.871912e-04  3.004395e-04
## ASV0031      1.480747e-05  1.507746e-05  1.532256e-05  1.553855e-05
## ASV1744     -4.032354e-05 -4.230480e-05 -4.438925e-05 -4.658294e-05
## ASV0289      3.214222e-04  3.361404e-04  3.515081e-04  3.675517e-04
## ASV7413     -7.619130e-05 -8.057309e-05 -8.521841e-05 -9.014289e-05
## ASV0822     -3.834018e-04 -4.000827e-04 -4.174216e-04 -4.354390e-04
## ASV8111     -3.205592e-04 -3.337305e-04 -3.473582e-04 -3.614515e-04
## ASV0687      2.426080e-04  2.539847e-04  2.658816e-04  2.783209e-04
## ASV0112      7.097683e-05  7.306965e-05  7.514933e-05  7.720598e-05
## ASV0987      1.956379e-04  2.048410e-04  2.144699e-04  2.245436e-04
## ASV5332     -1.039563e-04 -1.080687e-04 -1.123140e-04 -1.166945e-04
## ASV1129     -2.544849e-04 -2.661817e-04 -2.783990e-04 -2.911583e-04
## ASV1274     -8.350465e-05 -8.734561e-05 -9.135649e-05 -9.554415e-05
## ASV0119      4.709103e-04  4.925904e-04  5.152332e-04  5.388781e-04
## ASV0890      1.200997e-04  1.258341e-04  1.318406e-04  1.381317e-04
## ASV0848      6.738483e-04  7.045135e-04  7.365076e-04  7.698822e-04
## ASV5944     -3.469852e-04 -3.616818e-04 -3.769235e-04 -3.927241e-04
## ASV19741    -3.522785e-04 -3.681849e-04 -3.847715e-04 -4.020643e-04
## ASV0504     -4.014043e-04 -4.189863e-04 -4.372737e-04 -4.562892e-04
## ASV2146     -2.638933e-04 -2.755910e-04 -2.877764e-04 -3.004679e-04
## ASV0089     -2.232898e-04 -2.338624e-04 -2.449283e-04 -2.565095e-04
## ASV2301     -2.351690e-04 -2.460181e-04 -2.573508e-04 -2.691870e-04
## ASV2982      7.166119e-05  7.520303e-05  7.891458e-05  8.280279e-05
## ASV0891     -2.966499e-04 -3.101119e-04 -3.241548e-04 -3.388010e-04
## ASV0093      4.815794e-04  5.034127e-04  5.261864e-04  5.499367e-04
## ASV0042      2.266363e-04  2.366128e-04  2.469925e-04  2.577886e-04
## ASV0980      3.176167e-04  3.316134e-04  3.461767e-04  3.613252e-04
## ASV0069     -8.229109e-05 -8.638787e-05 -9.069452e-05 -9.522212e-05
## ASV1364     -5.737190e-05 -6.004052e-05 -6.283073e-05 -6.574786e-05
## ASV0524     -9.466125e-05 -9.931184e-05 -1.041951e-04 -1.093230e-04
## ASV0435      6.379909e-04  6.671757e-04  6.976403e-04  7.294357e-04
## ASV0517     -2.585718e-04 -2.702816e-04 -2.824935e-04 -2.952265e-04
## ASV3167     -1.125464e-04 -1.178578e-04 -1.234138e-04 -1.292248e-04
## ASV4280     -4.810811e-05 -5.057763e-05 -5.318119e-05 -5.592661e-05
## ASV1158      1.577136e-04  1.653840e-04  1.734241e-04  1.818504e-04
## ASV2214      1.208805e-04  1.264413e-04  1.322549e-04  1.383331e-04
## ASV0544     -1.434827e-04 -1.500863e-04 -1.569825e-04 -1.641832e-04
## ASV5326     -2.573089e-05 -2.684508e-05 -2.800309e-05 -2.920632e-05
## ASV3765     -3.691949e-04 -3.854078e-04 -4.022705e-04 -4.198038e-04
## ASV4646     -1.228879e-05 -1.357978e-05 -1.498604e-05 -1.651648e-05
## ASV0090      3.564113e-05  3.688286e-05  3.814499e-05  3.942548e-05
## ASV3680      3.464188e-04  3.611947e-04  3.765268e-04  3.924298e-04
## ASV0111      5.678135e-05  5.902641e-05  6.133902e-05  6.371925e-05
## ASV0768      2.185074e-04  2.285521e-04  2.390426e-04  2.499972e-04
## ASV4862     -1.230824e-05 -1.275886e-05 -1.321958e-05 -1.369002e-05
## ASV1742     -2.847529e-04 -2.970017e-04 -3.097246e-04 -3.229358e-04
## ASV3701     -5.091764e-05 -5.332511e-05 -5.584639e-05 -5.848686e-05
## ASV2386     -1.728421e-04 -1.805729e-04 -1.886257e-04 -1.970120e-04
## ASV0375     -4.019704e-04 -4.194962e-04 -4.377178e-04 -4.566570e-04
## ASV2796      1.070557e-04  1.116646e-04  1.164521e-04  1.214235e-04
## ASV1369      2.779820e-04  2.901597e-04  3.028285e-04  3.160047e-04
## ASV10272    -2.525297e-04 -2.637508e-04 -2.754338e-04 -2.875945e-04
## ASV10354    -2.525056e-04 -2.637245e-04 -2.754052e-04 -2.875633e-04
## ASV1067     -2.211866e-05 -2.323625e-05 -2.441236e-05 -2.565018e-05
## ASV1900      5.321189e-04  5.564894e-04  5.819303e-04  6.084843e-04
## ASV4079     -9.180275e-05 -9.613799e-05 -1.006738e-04 -1.054190e-04
## ASV4149      3.529728e-04  3.680701e-04  3.837388e-04  3.999944e-04
## ASV5140     -2.524813e-04 -2.636979e-04 -2.753761e-04 -2.875316e-04
## ASV10782    -1.064707e-05 -1.091722e-05 -1.118007e-05 -1.143374e-05
## ASV4273     -5.698658e-05 -5.927402e-05 -6.163298e-05 -6.406381e-05
## ASV8121      2.451077e-04  2.563429e-04  2.680743e-04  2.803222e-04
## ASV8438     -2.524604e-04 -2.636752e-04 -2.753515e-04 -2.875048e-04
## ASV9390     -2.524364e-04 -2.636490e-04 -2.753229e-04 -2.874737e-04
## ASV1340      3.523871e-04  3.686242e-04  3.855826e-04  4.032916e-04
## ASV2650     -3.738406e-04 -3.901930e-04 -4.071958e-04 -4.248692e-04
## ASV4674      1.927629e-04  2.014928e-04  2.105972e-04  2.200901e-04
## ASV10492    -1.693898e-05 -1.778586e-05 -1.867650e-05 -1.961322e-05
## ASV11430    -2.524009e-04 -2.636104e-04 -2.752809e-04 -2.874280e-04
## ASV12135    -2.523769e-04 -2.635842e-04 -2.752523e-04 -2.873968e-04
## ASV14970    -2.523528e-04 -2.635580e-04 -2.752237e-04 -2.873657e-04
## ASV1954      2.890681e-04  3.021562e-04  3.158047e-04  3.300345e-04
## ASV2613      4.511111e-04  4.714058e-04  4.925600e-04  5.146053e-04
## ASV2757      1.766357e-04  1.841824e-04  1.920142e-04  2.001387e-04
## ASV2909     -2.649563e-04 -2.770248e-04 -2.896170e-04 -3.027531e-04
## ASV2954     -5.000410e-05 -5.204750e-05 -5.415829e-05 -5.633720e-05
## ASV2969      2.510113e-04  2.626978e-04  2.749147e-04  2.876845e-04
## ASV3410      5.510971e-05  5.794393e-05  6.093076e-05  6.407881e-05
## ASV3575      1.329613e-04  1.390334e-04  1.453726e-04  1.519898e-04
## ASV4275      2.849853e-04  2.972532e-04  3.099915e-04  3.232134e-04
## ASV4652      5.198448e-05  5.465766e-05  5.747332e-05  6.043921e-05
## ASV4761      2.847977e-04  2.970740e-04  3.098212e-04  3.230525e-04
## ASV6003      2.250331e-04  2.357799e-04  2.470394e-04  2.588357e-04
## ASV6110     -2.524055e-04 -2.636156e-04 -2.752867e-04 -2.874346e-04
## ASV7427      1.657689e-04  1.732834e-04  1.811214e-04  1.892954e-04
## ASV8092     -2.523901e-04 -2.635989e-04 -2.752685e-04 -2.874148e-04
## ASV8169     -2.523661e-04 -2.635727e-04 -2.752399e-04 -2.873836e-04
## ASV9693      1.109935e-04  1.160605e-04  1.213484e-04  1.268659e-04
## ASV10913     1.234852e-04  1.293721e-04  1.355380e-04  1.419959e-04
## ASV1979     -4.084768e-05 -4.258866e-05 -4.439504e-05 -4.626855e-05
## ASV3772      3.129354e-04  3.268134e-04  3.412624e-04  3.563023e-04
## ASV0113      5.787011e-05  6.016406e-05  6.252618e-05  6.495626e-05
## ASV1800     -2.738462e-05 -2.870715e-05 -3.009196e-05 -3.154169e-05
## ASV2335     -3.131403e-04 -3.260208e-04 -3.393485e-04 -3.531325e-04
## ASV0692      1.097985e-04  1.149073e-04  1.202469e-04  1.258269e-04
## ASV1120      1.376592e-04  1.438714e-04  1.503479e-04  1.570987e-04
## ASV1434     -7.303360e-04 -7.633368e-04 -7.977487e-04 -8.336250e-04
## ASV0076     -8.636962e-05 -9.064715e-05 -9.514198e-05 -9.986544e-05
## ASV0361      5.551282e-04  5.806641e-04  6.073316e-04  6.351769e-04
## ASV2231     -1.899951e-04 -1.995004e-04 -2.094951e-04 -2.200049e-04
## ASV2018     -1.733641e-05 -1.860842e-05 -1.998061e-05 -2.146105e-05
## ASV1529      4.615008e-04  4.829101e-04  5.052852e-04  5.286669e-04
## ASV0841     -2.227184e-05 -2.308953e-05 -2.392518e-05 -2.477800e-05
## ASV2556     -2.752863e-04 -2.875752e-04 -3.003753e-04 -3.137043e-04
## ASV2777      3.447560e-04  3.594417e-04  3.746780e-04  3.904795e-04
## ASV0355      2.880167e-04  3.013408e-04  3.152635e-04  3.298104e-04
## ASV5169     -3.914774e-04 -4.090199e-04 -4.272981e-04 -4.463384e-04
## ASV3091      1.942156e-04  2.034266e-04  2.130708e-04  2.231682e-04
## ASV2435      2.757604e-04  2.879884e-04  3.007164e-04  3.139611e-04
## ASV6822     -1.781293e-04 -1.860445e-04 -1.942854e-04 -2.028632e-04
## ASV12605    -4.275867e-04 -4.467928e-04 -4.668089e-04 -4.876646e-04
## ASV0286     -2.861620e-04 -2.990606e-04 -3.125111e-04 -3.265348e-04
## ASV0074     -2.098570e-05 -2.272303e-05 -2.460583e-05 -2.664591e-05
## ASV2485     -1.029773e-05 -1.046408e-05 -1.061330e-05 -1.074295e-05
## ASV1233     -5.482252e-04 -5.732194e-04 -5.993039e-04 -6.265221e-04
## ASV0356     -2.603853e-04 -2.719322e-04 -2.839556e-04 -2.964720e-04
## ASV2918     -3.117891e-04 -3.248781e-04 -3.384420e-04 -3.524923e-04
## ASV1427     -1.238999e-06 -1.490441e-06 -1.770616e-06 -2.082249e-06
## ASV1409      3.234161e-04  3.386575e-04  3.546088e-04  3.713023e-04
## ASV0770      9.572683e-05  9.944756e-05  1.032696e-04  1.071911e-04
## ASV1403     -3.839526e-04 -4.012292e-04 -4.192377e-04 -4.380051e-04
## ASV0314     -2.088096e-04 -2.182948e-04 -2.281887e-04 -2.385067e-04
## ASV0187      2.488085e-06  2.208358e-06  1.884481e-06  1.512367e-06
## ASV0313     -2.772640e-04 -2.894307e-04 -3.020854e-04 -3.152437e-04
## ASV1087      4.880899e-04  5.104349e-04  5.337619e-04  5.581105e-04
## ASV1970      2.483639e-05  2.575647e-05  2.669758e-05  2.765890e-05
## ASV0754      3.927620e-04  4.107434e-04  4.295154e-04  4.491101e-04
## ASV3775     -2.686490e-04 -2.811431e-04 -2.942035e-04 -3.078546e-04
## ASV0132      1.083709e-04  1.130476e-04  1.179031e-04  1.229419e-04
## ASV2329     -8.029237e-05 -8.473666e-05 -8.943817e-05 -9.441177e-05
## ASV0561      3.326808e-04  3.473227e-04  3.625548e-04  3.783960e-04
## ASV0130     -4.101906e-04 -4.288634e-04 -4.483450e-04 -4.686668e-04
## ASV0226      4.650530e-04  4.861585e-04  5.081734e-04  5.311325e-04
## ASV12648    -3.288522e-04 -3.435364e-04 -3.588376e-04 -3.747787e-04
## ASV0204      4.635429e-04  4.845697e-04  5.065016e-04  5.293732e-04
## ASV0767      7.439796e-05  7.715891e-05  7.998239e-05  8.286565e-05
## ASV0335     -2.544382e-04 -2.660945e-04 -2.782621e-04 -2.909614e-04
## ASV5901     -7.395629e-05 -7.692843e-05 -7.999751e-05 -8.316493e-05
## ASV0596     -9.507448e-05 -9.880239e-05 -1.026387e-04 -1.065829e-04
## ASV9271      9.822449e-05  1.033733e-04  1.088006e-04  1.145212e-04
## ASV0904      4.095079e-04  4.282808e-04  4.478804e-04  4.683400e-04
## ASV15270    -1.084696e-04 -1.137739e-04 -1.193330e-04 -1.251583e-04
## ASV0990     -1.194971e-04 -1.252103e-04 -1.311962e-04 -1.374676e-04
## ASV0155     -2.453602e-04 -2.563684e-04 -2.678401e-04 -2.797920e-04
## ASV0086     -5.636050e-07 -4.633141e-07 -3.475560e-07 -2.147845e-07
## ASV2581     -1.317958e-05 -1.337212e-05 -1.353472e-05 -1.366263e-05
## ASV1579     -2.930503e-04 -3.069093e-04 -3.214159e-04 -3.365995e-04
## ASV7730     -1.463029e-05 -1.588998e-05 -1.725060e-05 -1.871929e-05
## ASV0897      1.192812e-04  1.247623e-04  1.304857e-04  1.364612e-04
## ASV1975      5.585578e-04  5.838077e-04  6.101389e-04  6.375924e-04
## ASV0759     -1.279135e-05 -1.324121e-05 -1.369931e-05 -1.416505e-05
## ASV3082     -3.397360e-04 -3.552409e-04 -3.714227e-04 -3.883082e-04
## ASV3195     -5.950474e-04 -6.226641e-04 -6.515292e-04 -6.816961e-04
## ASV0427      3.125494e-04  3.271071e-04  3.423267e-04  3.582366e-04
## ASV2674      6.341197e-05  6.608756e-05  6.885779e-05  7.172415e-05
## ASV1500      9.633076e-05  1.006819e-04  1.052197e-04  1.099512e-04
## ASV0102     -3.582224e-04 -3.750299e-04 -3.926128e-04 -4.110056e-04
## ASV1217     -8.833342e-05 -9.205873e-05 -9.591803e-05 -9.991393e-05
## ASV4998     -3.731017e-05 -3.899709e-05 -4.075573e-05 -4.258869e-05
## ASV2890      5.052812e-04  5.277638e-04  5.511770e-04  5.755535e-04
## ASV0672     -2.209273e-04 -2.310590e-04 -2.416379e-04 -2.526823e-04
## ASV6960     -2.024731e-04 -2.122742e-04 -2.225454e-04 -2.333079e-04
## ASV0821      3.270909e-04  3.414338e-04  3.563531e-04  3.718677e-04
## ASV1995     -3.153251e-04 -3.297644e-04 -3.448377e-04 -3.605704e-04
## ASV0211     -1.800056e-04 -1.887748e-04 -1.979736e-04 -2.076227e-04
## ASV0364      1.844119e-04  1.929174e-04  2.018029e-04  2.110843e-04
## ASV3616      3.892828e-04  4.059061e-04  4.231569e-04  4.410519e-04
## ASV1996      4.447866e-04  4.648704e-04  4.858147e-04  5.076526e-04
## ASV1881     -7.274246e-05 -7.613170e-05 -7.967492e-05 -8.337869e-05
## ASV1089      4.335930e-04  4.531563e-04  4.735521e-04  4.948114e-04
## ASV1450     -8.838329e-05 -9.223286e-05 -9.623405e-05 -1.003914e-04
## ASV4643     -2.474638e-04 -2.585903e-04 -2.701866e-04 -2.822698e-04
## ASV3458      1.228268e-04  1.285123e-04  1.344453e-04  1.406347e-04
## ASV2543     -1.100270e-04 -1.152904e-04 -1.208053e-04 -1.265835e-04
## ASV3306     -1.240830e-04 -1.298204e-04 -1.358072e-04 -1.420522e-04
## ASV0218     -2.424077e-04 -2.535319e-04 -2.651488e-04 -2.772786e-04
## ASV3727      1.643372e-04  1.722942e-04  1.806394e-04  1.893916e-04
## ASV4394     -1.765659e-04 -1.849410e-04 -1.937087e-04 -2.028867e-04
## ASV2636      1.747637e-05  1.910753e-05  2.088492e-05  2.282094e-05
## ASV5116      4.331967e-05  4.520172e-05  4.715751e-05  4.918922e-05
## ASV1394     -4.312693e-04 -4.510047e-04 -4.716068e-04 -4.931106e-04
## ASV0656     -4.211813e-04 -4.400466e-04 -4.597031e-04 -4.801796e-04
## ASV0475      6.437073e-04  6.733302e-04  7.042677e-04  7.365738e-04
## ASV1042      1.604599e-04  1.677825e-04  1.754236e-04  1.833953e-04
## ASV1199     -3.328238e-04 -3.482842e-04 -3.644448e-04 -3.813358e-04
## ASV12962    -2.165454e-05 -2.252630e-05 -2.342594e-05 -2.435370e-05
## ASV0853      3.000358e-04  3.135851e-04  3.277083e-04  3.424261e-04
## ASV5069     -7.316144e-05 -7.752529e-05 -8.216373e-05 -8.709401e-05
## ASV7825     -1.876796e-04 -1.962705e-04 -2.052376e-04 -2.145960e-04
## ASV0339      2.102360e-04  2.198614e-04  2.299103e-04  2.404001e-04
## ASV2965      1.832569e-04  1.916764e-04  2.004675e-04  2.096453e-04
## ASV2347     -2.413623e-04 -2.519958e-04 -2.630608e-04 -2.745717e-04
## ASV0541      1.084639e-04  1.138390e-04  1.194860e-04  1.254189e-04
## ASV0369      2.841952e-04  2.970030e-04  3.103550e-04  3.242714e-04
## ASV0171      1.443173e-04  1.509384e-04  1.578533e-04  1.650742e-04
## ASV2235      3.417480e-04  3.563649e-04  3.715368e-04  3.872794e-04
## ASV5809     -3.234772e-04 -3.379435e-04 -3.530141e-04 -3.687104e-04
## ASV1267      4.080877e-04  4.264764e-04  4.456445e-04  4.656206e-04
## ASV0207     -4.389761e-04 -4.586571e-04 -4.791638e-04 -5.005260e-04
## ASV3126     -5.222630e-04 -5.464056e-04 -5.716291e-04 -5.979785e-04
## ASV0183     -5.736763e-04 -5.997196e-04 -6.268873e-04 -6.552229e-04
## ASV1792      1.953003e-04  2.038758e-04  2.127948e-04  2.220679e-04
## ASV2001     -5.082219e-04 -5.318149e-04 -5.564751e-04 -5.822485e-04
## ASV5732     -4.975883e-04 -5.201709e-04 -5.437266e-04 -5.682925e-04
## ASV2857     -3.161891e-04 -3.307695e-04 -3.460008e-04 -3.619101e-04
## ASV1052     -2.289727e-04 -2.391913e-04 -2.498381e-04 -2.609290e-04
## ASV3226     -1.464332e-04 -1.531168e-04 -1.600920e-04 -1.673705e-04
## ASV3766     -5.429090e-05 -5.680948e-05 -5.944201e-05 -6.219339e-05
## ASV0982     -1.598513e-04 -1.675214e-04 -1.755599e-04 -1.839844e-04
## ASV0489     -5.695156e-06 -6.486937e-06 -7.360053e-06 -8.321675e-06
## ASV3990     -5.427890e-04 -5.678099e-04 -5.939455e-04 -6.212419e-04
## ASV0433     -3.198502e-04 -3.340252e-04 -3.487786e-04 -3.641296e-04
## ASV0684     -1.401887e-04 -1.469399e-04 -1.540198e-04 -1.614446e-04
## ASV0063     -3.801278e-04 -3.973874e-04 -4.153902e-04 -4.341643e-04
## ASV1399      6.226187e-05  6.444963e-05  6.667313e-05  6.892837e-05
## ASV3093     -6.477116e-04 -6.777976e-04 -7.092461e-04 -7.421156e-04
## ASV1771      8.008772e-05  8.397828e-05  8.805952e-05  9.234078e-05
## ASV7910     -3.215510e-04 -3.352440e-04 -3.494505e-04 -3.641840e-04
## ASV3718     -4.322401e-04 -4.519883e-04 -4.726002e-04 -4.941101e-04
## ASV0039     -3.422787e-04 -3.584116e-04 -3.752919e-04 -3.929528e-04
## ASV6469     -7.052186e-04 -7.371440e-04 -7.704374e-04 -8.051504e-04
## ASV8186     -4.783525e-04 -5.001924e-04 -5.229862e-04 -5.467719e-04
## ASV1091     -4.937449e-05 -5.178645e-05 -5.431786e-05 -5.697469e-05
## ASV16930    -5.852471e-04 -6.120673e-04 -6.400676e-04 -6.692957e-04
## ASV7234     -4.380936e-04 -4.581312e-04 -4.790472e-04 -5.008766e-04
## ASV1560     -5.303329e-05 -5.554945e-05 -5.818379e-05 -6.094172e-05
## ASV2968      8.964498e-05  9.401568e-05  9.860290e-05  1.034176e-04
## ASV3824     -4.496174e-04 -4.699704e-04 -4.911972e-04 -5.133313e-04
## ASV0442     -2.814578e-04 -2.944720e-04 -3.080693e-04 -3.222738e-04
## ASV0677     -2.110477e-04 -2.200223e-04 -2.293315e-04 -2.389835e-04
## ASV4796     -2.983822e-04 -3.116942e-04 -3.255627e-04 -3.400080e-04
## ASV2206     -4.785939e-04 -5.005833e-04 -5.235457e-04 -5.475210e-04
## ASV2884      9.538158e-05  9.976977e-05  1.043522e-04  1.091368e-04
## ASV0482     -1.739704e-04 -1.820307e-04 -1.904541e-04 -1.992561e-04
## ASV1273      3.981922e-04  4.166251e-04  4.358809e-04  4.559932e-04
## ASV1910      5.124847e-05  5.322213e-05  5.524979e-05  5.733085e-05
## ASV0105      2.986574e-04  3.117296e-04  3.253223e-04  3.394519e-04
## ASV0149      3.189315e-04  3.334977e-04  3.487000e-04  3.645636e-04
## ASV5007     -4.974929e-04 -5.203869e-04 -5.442967e-04 -5.692641e-04
## ASV0757      4.299277e-04  4.497981e-04  4.705590e-04  4.922478e-04
## ASV11952    -3.543998e-04 -3.702245e-04 -3.867073e-04 -4.038714e-04
## ASV4102      2.836334e-04  2.966970e-04  3.103404e-04  3.245874e-04
## ASV1034      3.565959e-04  3.726847e-04  3.894603e-04  4.069487e-04
## ASV0753      2.651958e-04  2.772687e-04  2.898664e-04  3.030093e-04
## ASV2323      1.614547e-04  1.689816e-04  1.768512e-04  1.850782e-04
## ASV0881     -1.246953e-04 -1.301725e-04 -1.358682e-04 -1.417891e-04
## ASV3730     -3.327926e-04 -3.479024e-04 -3.636642e-04 -3.801030e-04
## ASV2685     -1.263464e-04 -1.317449e-04 -1.373449e-04 -1.431511e-04
## ASV3826     -6.312413e-05 -6.602554e-05 -6.905656e-05 -7.222275e-05
## ASV0689      3.034958e-05  3.205434e-05  3.386240e-05  3.578041e-05
## ASV4315     -4.369702e-04 -4.571089e-04 -4.781449e-04 -5.001156e-04
## ASV1239      2.077933e-04  2.165064e-04  2.255349e-04  2.348862e-04
## ASV3147     -7.316300e-05 -7.667680e-05 -8.035977e-05 -8.421999e-05
## ASV3454     -3.252062e-04 -3.399606e-04 -3.553514e-04 -3.714034e-04
## ASV4411     -1.952307e-04 -2.044908e-04 -2.141883e-04 -2.243436e-04
## ASV3007      3.876795e-04  4.049149e-04  4.228607e-04  4.415413e-04
## ASV6151     -3.138396e-04 -3.276406e-04 -3.420001e-04 -3.569369e-04
## ASV0834      3.327965e-04  3.482633e-04  3.644294e-04  3.813247e-04
## ASV1231      4.761466e-04  4.978317e-04  5.204583e-04  5.440630e-04
## ASV0643      4.013175e-04  4.195613e-04  4.385940e-04  4.584459e-04
## ASV0924      1.163443e-05  1.216297e-05  1.271255e-05  1.328359e-05
## ASV3238     -1.974043e-04 -2.061460e-04 -2.152447e-04 -2.247124e-04
## ASV1276     -2.332785e-04 -2.438698e-04 -2.549178e-04 -2.664398e-04
## ASV5503     -6.302436e-04 -6.586488e-04 -6.882598e-04 -7.191207e-04
## ASV0404      2.548765e-04  2.666797e-04  2.790130e-04  2.918984e-04
## ASV3430      4.170990e-05  4.446858e-05  4.742429e-05  5.059148e-05
## ASV5401     -2.702829e-04 -2.827245e-04 -2.957186e-04 -3.092878e-04
## ASV3426     -5.747508e-04 -6.008121e-04 -6.279949e-04 -6.563421e-04
## ASV0777      3.421732e-04  3.577218e-04  3.739426e-04  3.908614e-04
## ASV11093    -2.300942e-04 -2.405723e-04 -2.515060e-04 -2.629133e-04
## ASV2170     -1.993009e-04 -2.081162e-04 -2.172904e-04 -2.268353e-04
## ASV3861      1.798393e-04  1.875564e-04  1.955661e-04  2.038759e-04
## ASV1723     -3.350700e-04 -3.504358e-04 -3.664784e-04 -3.832248e-04
## ASV2460     -1.901820e-04 -1.990124e-04 -2.082416e-04 -2.178865e-04
## ASV1218     -2.738104e-04 -2.860038e-04 -2.987028e-04 -3.119252e-04
## ASV0436      1.603521e-05  1.635116e-05  1.664378e-05  1.690893e-05
## ASV0919      2.336926e-04  2.441885e-04  2.551278e-04  2.665266e-04
## ASV0577      9.984433e-05  1.042938e-04  1.089273e-04  1.137512e-04
## ASV2517      2.655017e-04  2.773346e-04  2.896576e-04  3.024875e-04
## ASV2628     -3.246544e-04 -3.396230e-04 -3.552566e-04 -3.715822e-04
## ASV1743     -2.967459e-04 -3.105914e-04 -3.250681e-04 -3.402034e-04
## ASV1678     -2.563646e-04 -2.684408e-04 -2.810784e-04 -2.943028e-04
## ASV0315      3.326363e-04  3.479282e-04  3.638976e-04  3.805725e-04
## ASV0253      1.546192e-04  1.616002e-04  1.688779e-04  1.764634e-04
## ASV1363      4.178400e-04  4.362475e-04  4.553975e-04  4.753137e-04
## ASV0995     -2.317588e-04 -2.424199e-04 -2.535542e-04 -2.651812e-04
## ASV4185     -1.001810e-04 -1.044291e-04 -1.088344e-04 -1.134009e-04
## ASV0782      2.121100e-04  2.221391e-04  2.326390e-04  2.436313e-04
## ASV3240     -2.516714e-04 -2.633638e-04 -2.755860e-04 -2.883610e-04
## ASV1392     -4.563379e-04 -4.774598e-04 -4.995312e-04 -5.225923e-04
## ASV8488     -1.038367e-04 -1.086628e-04 -1.137087e-04 -1.189841e-04
## ASV2814     -1.691333e-04 -1.769389e-04 -1.850944e-04 -1.936144e-04
## ASV0678     -3.458919e-04 -3.622901e-04 -3.794608e-04 -3.974395e-04
## ASV1295     -2.406815e-04 -2.517307e-04 -2.632684e-04 -2.753145e-04
## ASV7517     -1.449723e-04 -1.512787e-04 -1.578326e-04 -1.646414e-04
## ASV2996     -4.679576e-04 -4.891228e-04 -5.111936e-04 -5.342040e-04
## ASV2882     -4.391730e-04 -4.588909e-04 -4.794408e-04 -5.008531e-04
## ASV1317      2.715263e-04  2.840372e-04  2.971039e-04  3.107490e-04
## ASV9106     -4.482726e-04 -4.688347e-04 -4.903035e-04 -5.127155e-04
## ASV9688     -4.265347e-04 -4.460818e-04 -4.664886e-04 -4.877894e-04
## ASV6181     -4.254223e-04 -4.448451e-04 -4.651159e-04 -4.862680e-04
## ASV2936      1.317332e-05  1.391826e-05  1.470843e-05  1.554673e-05
## ASV0192     -1.743465e-04 -1.819557e-04 -1.898633e-04 -1.980780e-04
## ASV2509     -2.162228e-04 -2.264808e-04 -2.372209e-04 -2.484652e-04
## ASV0863      7.409957e-04  7.738131e-04  8.079738e-04  8.435230e-04
## ASV2762     -1.917380e-04 -2.005638e-04 -2.097828e-04 -2.194116e-04
## ASV4904     -4.076051e-04 -4.262172e-04 -4.456422e-04 -4.659121e-04
## ASV0571      1.387058e-04  1.448972e-04  1.513491e-04  1.580713e-04
## ASV13304    -6.679067e-05 -7.031892e-05 -7.404375e-05 -7.797659e-05
## ASV6863     -9.261872e-05 -9.688888e-05 -1.013507e-04 -1.060123e-04
## ASV4844      3.585526e-05  3.796260e-05  4.020554e-05  4.259345e-05
## ASV10779    -4.469975e-04 -4.672794e-04 -4.884350e-04 -5.104980e-04
## ASV7921     -3.779160e-04 -3.952439e-04 -4.133356e-04 -4.322219e-04
## ASV8458     -3.928526e-04 -4.104812e-04 -4.288513e-04 -4.479896e-04
## ASV2593     -5.159069e-05 -5.348861e-05 -5.542747e-05 -5.740512e-05
## ASV4410     -2.144450e-04 -2.243271e-04 -2.346485e-04 -2.454273e-04
## ASV0593      5.520133e-04  5.778706e-04  6.049131e-04  6.331925e-04
## ASV2669      3.191546e-04  3.333237e-04  3.480741e-04  3.634253e-04
## ASV0868     -4.210035e-04 -4.402890e-04 -4.604226e-04 -4.814382e-04
## ASV3123     -1.496213e-04 -1.567924e-04 -1.643045e-04 -1.721733e-04
## ASV3482     -1.709721e-04 -1.786852e-04 -1.867261e-04 -1.951068e-04
## ASV2552     -4.697916e-04 -4.902717e-04 -5.115606e-04 -5.336829e-04
## ASV0723      5.351718e-04  5.585599e-04  5.828770e-04  6.081520e-04
## ASV0526     -3.581242e-04 -3.745153e-04 -3.916279e-04 -4.094912e-04
## ASV4623     -1.621843e-04 -1.697111e-04 -1.775773e-04 -1.857974e-04
## ASV2070     -4.989066e-04 -5.216491e-04 -5.453814e-04 -5.701424e-04
## ASV1198      1.243415e-05  1.293158e-05  1.344421e-05  1.397202e-05
## ASV3034      2.028896e-05  2.107535e-05  2.188439e-05  2.271607e-05
## ASV1208     -5.910246e-05 -6.177299e-05 -6.455824e-05 -6.746267e-05
## ASV4860      8.135622e-05  8.518267e-05  8.918538e-05  9.337198e-05
## ASV2493     -1.545997e-04 -1.616751e-04 -1.690617e-04 -1.767719e-04
## ASV4217     -1.052547e-04 -1.097283e-04 -1.143663e-04 -1.191723e-04
## ASV1516     -6.996724e-05 -7.376428e-05 -7.778244e-05 -8.203551e-05
## ASV1186      1.846724e-04  1.931385e-04  2.019778e-04  2.112052e-04
## ASV1906     -1.609086e-04 -1.683542e-04 -1.761346e-04 -1.842638e-04
## ASV8220     -2.627660e-05 -2.774459e-05 -2.930162e-05 -3.095353e-05
## ASV4227     -3.659602e-04 -3.826584e-04 -4.000849e-04 -4.182686e-04
## ASV1013      2.315661e-04  2.425960e-04  2.541468e-04  2.662423e-04
## ASV7952     -2.503018e-04 -2.622300e-04 -2.747242e-04 -2.878108e-04
## ASV5923     -2.833638e-04 -2.965094e-04 -3.102480e-04 -3.246049e-04
## ASV0190     -3.494950e-04 -3.651429e-04 -3.814456e-04 -3.984264e-04
## ASV0491     -3.961597e-05 -4.171768e-05 -4.393784e-05 -4.628353e-05
## ASV9535     -1.509053e-04 -1.578078e-04 -1.650120e-04 -1.725297e-04
## ASV9947     -1.150815e-04 -1.208531e-04 -1.269238e-04 -1.333096e-04
## ASV6518     -9.862862e-05 -1.031382e-04 -1.078457e-04 -1.127590e-04
## ASV1741     -1.020226e-04 -1.068364e-04 -1.118745e-04 -1.171468e-04
## ASV1874      1.894843e-04  1.977747e-04  2.063932e-04  2.153496e-04
## ASV2150      5.439908e-05  5.692012e-05  5.955459e-05  6.230725e-05
## ASV5262     -9.997560e-05 -1.044335e-04 -1.090763e-04 -1.139106e-04
## ASV1729     -3.625842e-04 -3.793206e-04 -3.968048e-04 -4.150678e-04
## ASV1522     -7.212360e-05 -7.593709e-05 -7.995946e-05 -8.420216e-05
## ASV3250      7.679764e-05  8.016410e-05  8.366512e-05  8.730494e-05
## ASV4338     -3.656972e-04 -3.824325e-04 -3.999023e-04 -4.181361e-04
## ASV1386      4.370328e-04  4.571307e-04  4.781194e-04  5.000353e-04
## ASV0694     -5.039538e-05 -5.295556e-05 -5.565178e-05 -5.849166e-05
## ASV2026      4.089411e-05  4.317240e-05  4.558706e-05  4.814673e-05
## ASV0191     -2.894007e-04 -3.022546e-04 -3.156365e-04 -3.295641e-04
## ASV1641      1.424651e-04  1.491985e-04  1.562443e-04  1.636162e-04
## ASV1326      7.075674e-04  7.398660e-04  7.735738e-04  8.087464e-04
## ASV4786     -2.171530e-05 -2.283645e-05 -2.401859e-05 -2.526521e-05
## ASV0342      1.787905e-04  1.872035e-04  1.960064e-04  2.052165e-04
## ASV3025     -2.046656e-04 -2.137342e-04 -2.231746e-04 -2.329992e-04
## ASV6533     -3.515469e-04 -3.672909e-04 -3.836951e-04 -4.007834e-04
## ASV1898      3.957825e-04  4.140161e-04  4.330582e-04  4.529414e-04
## ASV1940      2.242213e-04  2.344908e-04  2.452105e-04  2.563982e-04
## ASV4968     -4.098080e-04 -4.286941e-04 -4.484213e-04 -4.690241e-04
## ASV3401     -2.144906e-04 -2.242847e-04 -2.345069e-04 -2.451742e-04
## ASV3211      1.299733e-04  1.361881e-04  1.426988e-04  1.495191e-04
## ASV1489     -5.680113e-04 -5.938562e-04 -6.208202e-04 -6.489466e-04
## ASV4139     -3.333830e-04 -3.486502e-04 -3.645885e-04 -3.812248e-04
## ASV6059     -3.519158e-04 -3.680490e-04 -3.848934e-04 -4.024777e-04
## ASV0918      8.791358e-05  9.168250e-05  9.559393e-05  9.965157e-05
## ASV1449      3.418898e-04  3.575458e-04  3.738898e-04  3.909496e-04
## ASV5652     -2.348687e-04 -2.455942e-04 -2.567880e-04 -2.684685e-04
## ASV4091     -5.452733e-06 -5.185064e-06 -4.858975e-06 -4.468014e-06
## ASV7638     -2.173756e-04 -2.271215e-04 -2.372765e-04 -2.478553e-04
## ASV6525     -3.052445e-04 -3.187169e-04 -3.327386e-04 -3.473280e-04
## ASV8959     -3.180431e-04 -3.326867e-04 -3.479809e-04 -3.639525e-04
## ASV0699      2.425738e-04  2.536132e-04  2.651276e-04  2.771346e-04
## ASV2925      2.983908e-04  3.122083e-04  3.266469e-04  3.417326e-04
## ASV0618      6.658748e-05  6.984154e-05  7.325508e-05  7.683566e-05
## ASV2083      4.664111e-05  4.894949e-05  5.137482e-05  5.392316e-05
## ASV6192     -3.866901e-04 -4.042595e-04 -4.225878e-04 -4.417044e-04
## ASV8640     -4.372732e-04 -4.571653e-04 -4.779197e-04 -4.995698e-04
## ASV1103      1.788081e-04  1.867753e-04  1.950735e-04  2.037146e-04
## ASV4240     -1.983841e-05 -2.034779e-05 -2.084460e-05 -2.132540e-05
## ASV2180      1.137493e-04  1.189057e-04  1.242843e-04  1.298936e-04
## ASV9157     -2.801472e-04 -2.928488e-04 -3.060963e-04 -3.199103e-04
## ASV1307      5.515201e-04  5.769243e-04  6.034585e-04  6.311695e-04
## ASV4960     -1.365253e-04 -1.425575e-04 -1.488353e-04 -1.553669e-04
## ASV3930     -1.162721e-04 -1.214239e-04 -1.267875e-04 -1.323703e-04
## ASV1200     -2.414359e-04 -2.525804e-04 -2.642221e-04 -2.763816e-04
## ASV4676     -1.223697e-04 -1.279319e-04 -1.337348e-04 -1.397876e-04
## ASV6993     -4.537406e-04 -4.740995e-04 -4.953147e-04 -5.174171e-04
## ASV4813     -1.780771e-04 -1.861911e-04 -1.946573e-04 -2.034896e-04
## ASV4364     -5.855272e-04 -6.118842e-04 -6.393581e-04 -6.679899e-04
## ASV0141      2.303239e-04  2.400913e-04  2.502195e-04  2.607173e-04
## ASV3509      1.493622e-04  1.566273e-04  1.642513e-04  1.722521e-04
## ASV2751      2.479486e-04  2.593488e-04  2.712543e-04  2.836860e-04
## ASV4913     -2.533709e-04 -2.648403e-04 -2.768020e-04 -2.892748e-04
## ASV0138      6.284700e-04  6.571289e-04  6.870377e-04  7.182459e-04
## ASV7697     -1.756826e-04 -1.834310e-04 -1.914927e-04 -1.998779e-04
## ASV1602      8.872302e-05  9.230299e-05  9.599646e-05  9.980408e-05
## ASV5976     -3.519832e-04 -3.679875e-04 -3.846851e-04 -4.021030e-04
## ASV7525     -3.624419e-04 -3.788840e-04 -3.960349e-04 -4.139218e-04
## ASV4961      1.636729e-04  1.710646e-04  1.787704e-04  1.868017e-04
## ASV2546      4.396092e-04  4.588971e-04  4.789590e-04  4.998199e-04
## ASV0721     -2.671420e-04 -2.792765e-04 -2.919343e-04 -3.051355e-04
## ASV0542      2.453850e-04  2.565120e-04  2.681186e-04  2.802233e-04
## ASV3865      1.565670e-04  1.635312e-04  1.707826e-04  1.783312e-04
## ASV5571     -2.830337e-04 -2.954316e-04 -3.083233e-04 -3.217238e-04
## ASV6804      3.672304e-05  3.872197e-05  4.083788e-05  4.307811e-05
## ASV4424      2.642176e-04  2.763309e-04  2.889763e-04  3.021751e-04
## ASV3395      1.915512e-04  1.996487e-04  2.080436e-04  2.167432e-04
## ASV2394     -2.606220e-04 -2.725947e-04 -2.850973e-04 -2.981513e-04
## ASV8629     -2.605963e-04 -2.725667e-04 -2.850666e-04 -2.981178e-04
## ASV1018      2.358448e-04  2.466419e-04  2.579137e-04  2.696794e-04
## ASV6139     -5.277515e-04 -5.518544e-04 -5.770098e-04 -6.032592e-04
## ASV10411    -2.709323e-04 -2.833720e-04 -2.963615e-04 -3.099232e-04
## ASV3992     -1.056398e-04 -1.105802e-04 -1.157474e-04 -1.211515e-04
## ASV7131     -2.094287e-05 -2.194556e-05 -2.299681e-05 -2.409905e-05
## ASV3729     -4.331126e-05 -4.499849e-05 -4.673214e-05 -4.851147e-05
## ASV2197     -5.791635e-05 -6.048655e-05 -6.316258e-05 -6.594809e-05
## ASV2426     -2.710109e-04 -2.831230e-04 -2.957404e-04 -3.088812e-04
## ASV3669     -2.556590e-04 -2.676615e-04 -2.802193e-04 -2.933572e-04
## ASV1820      1.338704e-04  1.398902e-04  1.461639e-04  1.527005e-04
## ASV7081     -2.412677e-04 -2.523706e-04 -2.639672e-04 -2.760779e-04
## ASV7872     -3.057216e-04 -3.195207e-04 -3.339079e-04 -3.489051e-04
## ASV1670     -3.613993e-05 -3.755356e-05 -3.900691e-05 -4.049952e-05
## ASV0712      2.985954e-04  3.128519e-04  3.277867e-04  3.434317e-04
## ASV0474      4.513472e-04  4.708702e-04  4.911517e-04  5.122137e-04
## ASV1196      4.512428e-04  4.719450e-04  4.935605e-04  5.161262e-04
## ASV0845      2.830103e-04  2.957859e-04  3.091079e-04  3.229968e-04
## ASV12393    -5.752795e-04 -6.016496e-04 -6.291800e-04 -6.579170e-04
## ASV5867     -2.216148e-04 -2.318426e-04 -2.425260e-04 -2.536837e-04
## ASV17619    -8.454437e-05 -8.869045e-05 -9.304424e-05 -9.761644e-05
## ASV4686     -1.958783e-04 -2.049716e-04 -2.144763e-04 -2.244102e-04
## ASV3520     -3.181233e-04 -3.326440e-04 -3.477987e-04 -3.636127e-04
## ASV10800    -5.206388e-04 -5.445880e-04 -5.695993e-04 -5.957161e-04
## ASV2706      4.622908e-04  4.836610e-04  5.059879e-04  5.293114e-04
## ASV1227     -6.400770e-05 -6.680063e-05 -6.970379e-05 -7.272050e-05
## ASV2621      4.255242e-04  4.454963e-04  4.663906e-04  4.882480e-04
## ASV0460      9.546020e-05  1.000612e-04  1.048849e-04  1.099421e-04
## ASV1069     -3.473728e-04 -3.634816e-04 -3.803167e-04 -3.979088e-04
## ASV6939     -3.192981e-04 -3.337372e-04 -3.487944e-04 -3.644931e-04
## ASV2862     -4.442675e-04 -4.645218e-04 -4.856578e-04 -5.077101e-04
## ASV1021     -2.595666e-04 -2.711163e-04 -2.831429e-04 -2.956630e-04
## ASV3845      2.067915e-04  2.163296e-04  2.262918e-04  2.366955e-04
## ASV0732      1.818585e-04  1.904270e-04  1.993938e-04  2.087766e-04
## ASV10731     1.391912e-04  1.454483e-04  1.519692e-04  1.587636e-04
## ASV3378      1.651647e-04  1.723022e-04  1.797149e-04  1.874107e-04
## ASV7154      1.211333e-05  1.229540e-05  1.245073e-05  1.257503e-05
## ASV9876      7.804100e-05  8.175001e-05  8.563398e-05  8.970094e-05
## ASV0631      3.493736e-04  3.657192e-04  3.828154e-04  4.006954e-04
## ASV13027    -2.640588e-04 -2.763540e-04 -2.892085e-04 -3.026467e-04
## ASV2497     -2.640325e-04 -2.763251e-04 -2.891769e-04 -3.026120e-04
## ASV3966     -3.724792e-04 -3.898675e-04 -4.080508e-04 -4.270639e-04
## ASV2574      2.199026e-04  2.295318e-04  2.395437e-04  2.499497e-04
## ASV0545     -2.069551e-04 -2.166607e-04 -2.268120e-04 -2.374283e-04
## ASV8453     -2.343571e-04 -2.452577e-04 -2.566535e-04 -2.685658e-04
## ASV0221     -1.238030e-04 -1.295217e-04 -1.354964e-04 -1.417379e-04
## ASV3305      1.678504e-04  1.757812e-04  1.840832e-04  1.927734e-04
## ASV2647     -1.145430e-04 -1.196179e-04 -1.249000e-04 -1.303964e-04
## ASV5789     -5.347342e-04 -5.596952e-04 -5.857974e-04 -6.130909e-04
## ASV1731     -1.668173e-04 -1.739274e-04 -1.813038e-04 -1.889535e-04
## ASV3857      7.437443e-05  7.767703e-05  8.111576e-05  8.469532e-05
## ASV0405      3.123441e-04  3.261543e-04  3.405265e-04  3.554792e-04
## ASV0094     -3.555436e-04 -3.707053e-04 -3.864398e-04 -4.027629e-04
## ASV0158     -1.200236e-05 -1.225928e-05 -1.250306e-05 -1.273123e-05
## ASV5507     -3.143771e-04 -3.287580e-04 -3.437699e-04 -3.594382e-04
## ASV1023     -1.206518e-06 -8.013023e-07 -3.350883e-07  1.986228e-07
## ASV0488     -2.045794e-04 -2.139756e-04 -2.237869e-04 -2.340301e-04
## ASV1459      1.706078e-04  1.780699e-04  1.858300e-04  1.938975e-04
## ASV4349     -5.082359e-05 -5.290730e-05 -5.506090e-05 -5.728535e-05
## ASV1172      5.291896e-04  5.531187e-04  5.780714e-04  6.040861e-04
## ASV10187    -1.399289e-04 -1.465524e-04 -1.534871e-04 -1.607473e-04
## ASV7227      8.264654e-05  8.651376e-05  9.055872e-05  9.478929e-05
## ASV10340     8.132576e-05  8.521858e-05  8.929840e-05  9.357424e-05
## ASV10821    -1.500924e-04 -1.569386e-04 -1.640828e-04 -1.715366e-04
## ASV13810    -1.500777e-04 -1.569226e-04 -1.640652e-04 -1.715174e-04
## ASV3230     -1.205878e-04 -1.261069e-04 -1.318679e-04 -1.378802e-04
## ASV5524      1.215881e-05  1.259073e-05  1.303022e-05  1.347658e-05
## ASV8742     -1.500520e-04 -1.568945e-04 -1.640345e-04 -1.714838e-04
## ASV9188      3.297759e-04  3.443317e-04  3.594769e-04  3.752306e-04
## ASV4658      1.680083e-04  1.756907e-04  1.837089e-04  1.920763e-04
## ASV7889      2.030721e-04  2.119051e-04  2.210866e-04  2.306274e-04
## ASV1466      4.899993e-05  5.165937e-05  5.447298e-05  5.745023e-05
## ASV1424     -9.418450e-05 -9.772525e-05 -1.013514e-04 -1.050600e-04
## ASV0098     -2.592257e-04 -2.713022e-04 -2.839265e-04 -2.971218e-04
## ASV0067     -4.132955e-04 -4.321942e-04 -4.519202e-04 -4.725065e-04
## ASV9434     -1.714045e-04 -1.791823e-04 -1.872953e-04 -1.957561e-04
## ASV3270     -6.825446e-05 -7.150714e-05 -7.491341e-05 -7.848024e-05
## ASV4518     -2.932418e-04 -3.064292e-04 -3.201739e-04 -3.344962e-04
## ASV7661     -2.750176e-04 -2.871319e-04 -2.997352e-04 -3.128434e-04
## ASV4223      3.173092e-05  3.322343e-05  3.478423e-05  3.641617e-05
## ASV3481      2.384118e-04  2.500538e-04  2.622748e-04  2.751040e-04
## ASV7819     -4.340103e-04 -4.538477e-04 -4.745540e-04 -4.961640e-04
## ASV3095     -1.822259e-05 -1.895856e-05 -1.971700e-05 -2.049779e-05
## ASV4476     -8.964344e-05 -9.389353e-05 -9.834388e-05 -1.030038e-04
## ASV1713      2.600486e-04  2.714134e-04  2.832294e-04  2.955105e-04
## ASV11165    -6.768867e-05 -7.056156e-05 -7.353940e-05 -7.662442e-05
## ASV2179      5.379348e-04  5.625930e-04  5.883366e-04  6.152093e-04
## ASV3747      4.610792e-04  4.821851e-04  5.042166e-04  5.272106e-04
## ASV1410      2.381950e-05  2.461177e-05  2.541244e-05  2.621956e-05
## ASV6069     -2.897213e-04 -3.030085e-04 -3.168816e-04 -3.313645e-04
## ASV1939      8.101681e-05  8.492609e-05  8.902522e-05  9.332340e-05
## ASV7865     -4.514083e-04 -4.720556e-04 -4.936071e-04 -5.160986e-04
## ASV4488     -4.156823e-04 -4.349493e-04 -4.550844e-04 -4.761243e-04
## ASV0938      3.277812e-04  3.426954e-04  3.582562e-04  3.744886e-04
## ASV7852     -2.483417e-04 -2.594743e-04 -2.710754e-04 -2.831621e-04
## ASV2503     -2.407215e-05 -2.543383e-05 -2.688053e-05 -2.841813e-05
## ASV2993     -3.558328e-04 -3.722834e-04 -3.894707e-04 -4.074255e-04
## ASV3752     -4.364586e-05 -4.557882e-05 -4.759086e-05 -4.968467e-05
## ASV2557     -3.625694e-04 -3.793459e-04 -3.968731e-04 -4.151821e-04
## ASV6522     -7.448300e-05 -7.777436e-05 -8.119937e-05 -8.476242e-05
## ASV0088     -2.667298e-04 -2.782044e-04 -2.901173e-04 -3.024805e-04
## ASV7935     -2.239216e-04 -2.340859e-04 -2.446888e-04 -2.557472e-04
## ASV0942     -2.859148e-04 -2.991477e-04 -3.129741e-04 -3.274188e-04
## ASV7709     -3.328821e-04 -3.476614e-04 -3.630481e-04 -3.790629e-04
## ASV4588     -1.698984e-04 -1.772579e-04 -1.849041e-04 -1.928456e-04
## ASV5765     -4.761820e-04 -4.978610e-04 -5.204805e-04 -5.440772e-04
## ASV3562     -2.352099e-05 -2.430381e-05 -2.509352e-05 -2.588783e-05
## ASV9076     -3.644306e-04 -3.811377e-04 -3.985808e-04 -4.167898e-04
## ASV4707     -4.067729e-04 -4.254777e-04 -4.450114e-04 -4.654077e-04
## ASV2188      2.902479e-04  3.038047e-04  3.179820e-04  3.328068e-04
## ASV0613      5.468921e-05  5.747572e-05  6.040806e-05  6.349388e-05
## ASV0663     -1.834415e-04 -1.919135e-04 -2.007645e-04 -2.100101e-04
## ASV3361     -3.603580e-04 -3.758271e-04 -3.918862e-04 -4.085512e-04
## ASV1478      4.026612e-04  4.207939e-04  4.396953e-04  4.593938e-04
## ASV0213      2.238297e-04  2.339542e-04  2.445122e-04  2.555201e-04
## ASV7674     -1.222447e-04 -1.276942e-04 -1.333702e-04 -1.392808e-04
## ASV2137     -1.308814e-04 -1.366600e-04 -1.426728e-04 -1.489275e-04
## ASV8246     -1.092920e-04 -1.142046e-04 -1.193252e-04 -1.246615e-04
## ASV0047     -3.461099e-04 -3.615582e-04 -3.776490e-04 -3.944052e-04
## ASV6117      1.232655e-05  1.304436e-05  1.380701e-05  1.461739e-05
## ASV3349     -6.639494e-05 -6.943886e-05 -7.261677e-05 -7.593405e-05
## ASV10881    -2.275148e-04 -2.379237e-04 -2.487885e-04 -2.601271e-04
## ASV6979     -1.540674e-04 -1.612269e-04 -1.687103e-04 -1.765315e-04
## ASV7930     -2.972200e-04 -3.107297e-04 -3.248241e-04 -3.395257e-04
## ASV7322      9.997986e-05  1.045919e-04  1.094093e-04  1.144406e-04
## ASV4927     -5.086230e-05 -5.332932e-05 -5.591700e-05 -5.863121e-05
## ASV9054     -1.657768e-04 -1.732372e-04 -1.810145e-04 -1.891205e-04
## ASV2692     -1.301092e-04 -1.364308e-04 -1.430579e-04 -1.500045e-04
## ASV1666     -8.687881e-05 -9.041156e-05 -9.405922e-05 -9.782282e-05
## ASV4728      1.900925e-04  1.985251e-04  2.073051e-04  2.164446e-04
## ASV3097      1.278179e-04  1.338327e-04  1.401269e-04  1.467130e-04
## ASV4962     -1.036597e-04 -1.088116e-04 -1.142258e-04 -1.199159e-04
## ASV5057      1.569049e-04  1.643405e-04  1.721263e-04  1.802786e-04
## ASV2639      2.835877e-04  2.969536e-04  3.109412e-04  3.255784e-04
## ASV1808     -3.566662e-05 -3.787011e-05 -4.021995e-05 -4.272613e-05
## ASV6333     -5.438541e-05 -5.721563e-05 -6.020139e-05 -6.335175e-05
## ASV4328     -1.263113e-04 -1.320677e-04 -1.380742e-04 -1.443409e-04
## ASV7707     -3.710798e-04 -3.877610e-04 -4.051459e-04 -4.232602e-04
## ASV11022    -3.598355e-04 -3.759517e-04 -3.927432e-04 -4.102341e-04
## ASV1469     -6.728794e-05 -7.030242e-05 -7.344378e-05 -7.671671e-05
## ASV3919     -1.251785e-04 -1.311029e-04 -1.373043e-04 -1.437953e-04
## ASV4038     -2.522972e-04 -2.637522e-04 -2.757018e-04 -2.881653e-04
## ASV4048      9.135034e-05  9.583200e-05  1.005370e-04  1.054764e-04
## ASV0634      1.048284e-04  1.097573e-04  1.149156e-04  1.203136e-04
## ASV1852     -2.861702e-04 -2.997438e-04 -3.139563e-04 -3.288371e-04
## ASV2505      2.138435e-04  2.235815e-04  2.337436e-04  2.443468e-04
## ASV1762     -3.280259e-04 -3.428957e-04 -3.584054e-04 -3.745794e-04
## ASV3761     -2.785107e-04 -2.911752e-04 -3.043879e-04 -3.181701e-04
## ASV0775     -4.721942e-04 -4.936164e-04 -5.159612e-04 -5.392640e-04
## ASV10911    -3.461114e-04 -3.617713e-04 -3.781025e-04 -3.951306e-04
## ASV1339     -5.852982e-05 -6.108223e-05 -6.373453e-05 -6.648954e-05
## ASV5214     -7.852380e-05 -8.197877e-05 -8.557220e-05 -8.930836e-05
## ASV4945      9.184276e-05  9.608656e-05  1.005196e-04  1.051496e-04
## ASV5624     -7.365364e-05 -7.669086e-05 -7.983081e-05 -8.307484e-05
## ASV3429     -4.205559e-05 -4.380024e-05 -4.560657e-05 -4.747592e-05
## ASV8416     -4.117707e-05 -4.339560e-05 -4.574105e-05 -4.822099e-05
## ASV2400     -4.276023e-04 -4.471317e-04 -4.675143e-04 -4.887839e-04
## ASV3388     -1.402649e-04 -1.469067e-04 -1.538599e-04 -1.611385e-04
## ASV7089      8.600733e-05  8.965286e-05  9.343159e-05  9.734642e-05
## ASV3396     -1.418722e-04 -1.481692e-04 -1.547236e-04 -1.615439e-04
## ASV0343      2.060907e-04  2.161518e-04  2.267112e-04  2.377936e-04
## ASV5505     -2.598352e-04 -2.718895e-04 -2.844881e-04 -2.976543e-04
## ASV6721     -1.230665e-04 -1.289073e-04 -1.350237e-04 -1.414285e-04
## ASV0537      1.094676e-04  1.152540e-04  1.213635e-04  1.278150e-04
## ASV7753     -3.364756e-04 -3.519316e-04 -3.680713e-04 -3.849224e-04
## ASV5022     -2.835944e-05 -3.000148e-05 -3.174565e-05 -3.359854e-05
## ASV1073      4.701208e-04  4.917369e-04  5.143107e-04  5.378814e-04
## ASV1347     -1.357179e-06 -1.498020e-06 -1.653603e-06 -1.825471e-06
## ASV15032     1.409942e-04  1.471700e-04  1.535905e-04  1.602631e-04
## ASV18213    -1.367878e-06 -1.509657e-06 -1.666254e-06 -1.839219e-06
## ASV20691     1.206056e-04  1.262374e-04  1.321256e-04  1.382813e-04
## ASV4260     -6.189205e-05 -6.476083e-05 -6.776010e-05 -7.089567e-05
## ASV4923      1.047106e-04  1.095887e-04  1.146876e-04  1.200168e-04
## ASV7995     -1.381918e-06 -1.525017e-06 -1.683055e-06 -1.857591e-06
## ASV8960      2.101968e-04  2.197381e-04  2.296894e-04  2.400664e-04
## ASV10682     1.579972e-04  1.647279e-04  1.717083e-04  1.789443e-04
## ASV11911    -1.408242e-06 -1.553701e-06 -1.714301e-06 -1.891615e-06
## ASV14296     2.519345e-04  2.631271e-04  2.747788e-04  2.869051e-04
## ASV2314      1.472928e-04  1.546325e-04  1.623476e-04  1.704579e-04
## ASV3819      1.626432e-04  1.698721e-04  1.773971e-04  1.852279e-04
## ASV4517     -1.448588e-06 -1.597793e-06 -1.762477e-06 -1.944242e-06
## ASV8941      3.131776e-04  3.276708e-04  3.428144e-04  3.586356e-04
## ASV1444      1.467727e-06  1.618728e-06  1.785371e-06  1.969273e-06
## ASV5959      5.677017e-05  5.929703e-05  6.192688e-05  6.466291e-05
## ASV3623     -1.437939e-04 -1.502206e-04 -1.569164e-04 -1.638911e-04
## ASV0260      1.745333e-04  1.825991e-04  1.910264e-04  1.998302e-04
## ASV4401     -1.175259e-04 -1.234992e-04 -1.297810e-04 -1.363868e-04
## ASV2891     -3.810696e-04 -3.987253e-04 -4.171761e-04 -4.364558e-04
## ASV2778     -8.565453e-05 -8.959867e-05 -9.371816e-05 -9.802024e-05
## ASV8744      1.659990e-04  1.731896e-04  1.806615e-04  1.884232e-04
## ASV1079      3.420378e-04  3.571241e-04  3.728239e-04  3.891579e-04
## ASV19688     2.698117e-05  2.847952e-05  3.006774e-05  3.175160e-05
## ASV4039      4.398032e-05  4.631251e-05  4.877645e-05  5.138009e-05
## ASV4982     -2.579863e-04 -2.697162e-04 -2.819542e-04 -2.947200e-04
## ASV1071     -2.579612e-04 -2.696887e-04 -2.819241e-04 -2.946872e-04
## ASV7666     -2.579360e-04 -2.696612e-04 -2.818941e-04 -2.946544e-04
## ASV0502      3.615326e-04  3.781232e-04  3.954459e-04  4.135303e-04
## ASV3624     -2.583918e-04 -2.701532e-04 -2.824247e-04 -2.952262e-04
## ASV0403      3.612098e-05  3.759979e-05  3.912831e-05  4.070724e-05
## ASV4939     -2.583639e-04 -2.701227e-04 -2.823914e-04 -2.951898e-04
## ASV6297     -3.102228e-04 -3.245217e-04 -3.394570e-04 -3.550550e-04
## ASV6343      2.728195e-04  2.845154e-04  2.966564e-04  3.092548e-04
## ASV0954     -5.673115e-05 -5.895303e-05 -6.123753e-05 -6.358394e-05
## ASV10225    -1.134446e-04 -1.187964e-04 -1.243952e-04 -1.302515e-04
## ASV1584      4.492961e-04  4.697527e-04  4.910970e-04  5.133635e-04
## ASV1803      1.635469e-04  1.706352e-04  1.779974e-04  1.856410e-04
## ASV2576     -4.492403e-04 -4.696917e-04 -4.910304e-04 -5.132909e-04
## ASV3252      2.927393e-04  3.061999e-04  3.202566e-04  3.349335e-04
## ASV3463     -4.491942e-04 -4.696413e-04 -4.909754e-04 -5.132308e-04
## ASV3822     -3.428556e-04 -3.587792e-04 -3.754239e-04 -3.928208e-04
## ASV4926     -1.794761e-04 -1.871415e-04 -1.950938e-04 -2.033400e-04
## ASV5564     -1.161517e-04 -1.214495e-04 -1.269785e-04 -1.327481e-04
## ASV5595     -6.770845e-05 -7.077639e-05 -7.397665e-05 -7.731438e-05
## ASV16463    -2.625612e-04 -2.747180e-04 -2.874218e-04 -3.006957e-04
## ASV6277      2.630735e-04  2.754253e-04  2.883464e-04  3.018618e-04
## ASV1344      2.625491e-04  2.747047e-04  2.874072e-04  3.006798e-04
## ASV1869      1.657254e-04  1.729505e-04  1.804590e-04  1.882592e-04
## ASV8155     -1.418576e-04 -1.479880e-04 -1.543545e-04 -1.609638e-04
## ASV2502     -2.640842e-04 -2.760443e-04 -2.885176e-04 -3.015234e-04
## ASV6742     -8.117139e-05 -8.454796e-05 -8.804263e-05 -9.165753e-05
## ASV3124     -1.714572e-04 -1.792177e-04 -1.873134e-04 -1.957577e-04
## ASV17042    -3.005382e-04 -3.142038e-04 -3.284605e-04 -3.433312e-04
## ASV0248      4.158448e-04  4.345510e-04  4.540496e-04  4.743698e-04
## ASV4557      7.293579e-05  7.675426e-05  8.078054e-05  8.502605e-05
## ASV3507     -4.581391e-04 -4.792810e-04 -5.013665e-04 -5.244350e-04
## ASV1870      3.362008e-05  3.516145e-05  3.677065e-05  3.845039e-05
## ASV2447     -2.213109e-04 -2.316642e-04 -2.424938e-04 -2.538211e-04
## ASV0347      3.589213e-04  3.756103e-04  3.930566e-04  4.112931e-04
## ASV1855     -1.644477e-04 -1.720362e-04 -1.799637e-04 -1.882446e-04
## ASV0568      1.231118e-04  1.286723e-04  1.344705e-04  1.405153e-04
## ASV1620     -2.199105e-04 -2.299941e-04 -2.405217e-04 -2.515111e-04
## ASV0101     -1.751545e-04 -1.825534e-04 -1.902228e-04 -1.981690e-04
## ASV7751      1.674284e-04  1.755601e-04  1.840922e-04  1.930446e-04
## ASV9033     -3.013364e-04 -3.152737e-04 -3.298362e-04 -3.450504e-04
## ASV3438     -8.768273e-05 -9.181004e-05 -9.612945e-05 -1.006497e-04
## ASV0637     -2.808859e-04 -2.937556e-04 -3.071911e-04 -3.212153e-04
## ASV1181     -2.080166e-04 -2.176489e-04 -2.277139e-04 -2.382296e-04
## ASV13480    -2.617817e-04 -2.738572e-04 -2.864712e-04 -2.996457e-04
## ASV14220    -2.617558e-04 -2.738289e-04 -2.864402e-04 -2.996118e-04
## ASV1448     -1.914973e-04 -2.003970e-04 -2.096998e-04 -2.194229e-04
## ASV1457      1.745281e-04  1.822045e-04  1.901892e-04  1.984916e-04
## ASV1645      1.274012e-04  1.334040e-04  1.396857e-04  1.462590e-04
## ASV2300     -1.696750e-04 -1.773143e-04 -1.852767e-04 -1.935741e-04
## ASV2533      2.609898e-04  2.727053e-04  2.849135e-04  2.976320e-04
## ASV5059      6.315069e-05  6.572472e-05  6.838363e-05  7.112840e-05
## ASV8871     -2.617450e-04 -2.738170e-04 -2.864270e-04 -2.995973e-04
## ASV1289     -2.792177e-04 -2.918314e-04 -3.049838e-04 -3.186951e-04
## ASV3983     -1.199181e-04 -1.255588e-04 -1.314609e-04 -1.376358e-04
## ASV10323    -9.598329e-05 -1.007038e-04 -1.056610e-04 -1.108671e-04
## ASV13279    -2.616788e-04 -2.737445e-04 -2.863477e-04 -2.995105e-04
## ASV7149     -2.616530e-04 -2.737162e-04 -2.863167e-04 -2.994766e-04
## ASV1691      5.018027e-05  5.256685e-05  5.506737e-05  5.768737e-05
## ASV1649      1.289127e-04  1.349207e-04  1.412002e-04  1.477625e-04
## ASV10120     3.819873e-05  4.005177e-05  4.199600e-05  4.403600e-05
## ASV8285     -3.350533e-04 -3.508105e-04 -3.672959e-04 -3.845416e-04
## ASV0037     -2.876489e-04 -3.010747e-04 -3.151138e-04 -3.297928e-04
## ASV1770      7.492332e-05  7.836455e-05  8.195855e-05  8.571167e-05
## ASV2252      7.163661e-05  7.491382e-05  7.833421e-05  8.190337e-05
## ASV7580      2.877850e-04  3.005319e-04  3.137999e-04  3.276067e-04
## ASV5643     -2.646728e-04 -2.768390e-04 -2.895444e-04 -3.028109e-04
## ASV2722     -8.611408e-05 -9.034195e-05 -9.478236e-05 -9.944636e-05
## ASV2662     -1.818640e-04 -1.902928e-04 -1.991023e-04 -2.083090e-04
## ASV0479     -4.128664e-04 -4.314811e-04 -4.508881e-04 -4.711169e-04
## ASV2009     -4.333276e-04 -4.525394e-04 -4.725379e-04 -4.933494e-04
## ASV3731     -2.926055e-04 -3.057247e-04 -3.193947e-04 -3.336352e-04
## ASV5497     -3.629017e-04 -3.793974e-04 -3.966072e-04 -4.145586e-04
## ASV6647      1.530165e-05  1.581420e-05  1.633124e-05  1.685119e-05
## ASV8974     -2.671724e-04 -2.792387e-04 -2.918195e-04 -3.049340e-04
## ASV15527     2.307848e-05  2.404563e-05  2.504745e-05  2.608467e-05
## ASV6705     -1.676281e-04 -1.759332e-04 -1.846611e-04 -1.938337e-04
## ASV0354      3.427474e-04  3.584947e-04  3.749387e-04  3.921078e-04
## ASV2707      7.717935e-05  8.043813e-05  8.381507e-05  8.731270e-05
## ASV11167    -4.497554e-04 -4.702618e-04 -4.916602e-04 -5.139855e-04
## ASV6393     -3.581586e-04 -3.745584e-04 -3.916783e-04 -4.095472e-04
## ASV3808     -2.540947e-04 -2.654050e-04 -2.771846e-04 -2.894502e-04
## ASV9337      3.433980e-05  3.565161e-05  3.699636e-05  3.837304e-05
## ASV5043     -3.673805e-04 -3.841907e-04 -4.017380e-04 -4.200517e-04
## ASV4189     -9.728749e-06 -9.945148e-06 -1.014987e-05 -1.034050e-05
## ASV1304     -1.374892e-04 -1.432019e-04 -1.491149e-04 -1.552323e-04
## ASV2105     -1.926735e-04 -2.015238e-04 -2.107657e-04 -2.204153e-04
## ASV2421     -6.739292e-05 -7.057974e-05 -7.391660e-05 -7.741053e-05
## ASV3170      3.086816e-04  3.230359e-04  3.380418e-04  3.537273e-04
## ASV5036      4.121598e-04  4.309769e-04  4.506157e-04  4.711088e-04
## ASV2286      2.602435e-04  2.721826e-04  2.846487e-04  2.976632e-04
## ASV3363      2.615290e-04  2.738344e-04  2.867109e-04  3.001842e-04
## ASV5759     -2.443532e-05 -2.567447e-05 -2.697986e-05 -2.835530e-05
## ASV5440     -1.817426e-04 -1.904470e-04 -1.995684e-04 -2.091268e-04
## ASV2050      2.964930e-04  3.094288e-04  3.228727e-04  3.368393e-04
## ASV4478      2.144016e-04  2.245421e-04  2.351577e-04  2.462702e-04
## ASV5725     -2.288914e-04 -2.391911e-04 -2.499274e-04 -2.611164e-04
## ASV1600     -6.883227e-05 -7.260626e-05 -7.660111e-05 -8.083037e-05
## ASV1654     -4.076878e-04 -4.260780e-04 -4.452519e-04 -4.652388e-04
## ASV3781     -1.752691e-04 -1.830175e-04 -1.910808e-04 -1.994693e-04
## ASV7144     -1.503466e-04 -1.569472e-04 -1.638113e-04 -1.709473e-04
## ASV12710    -5.407254e-05 -5.612419e-05 -5.822742e-05 -6.038084e-05
## ASV3317      2.059398e-04  2.153275e-04  2.251256e-04  2.353506e-04
## ASV3249     -4.033951e-04 -4.217889e-04 -4.409829e-04 -4.610085e-04
## ASV0669     -2.499939e-04 -2.610095e-04 -2.724707e-04 -2.843919e-04
## ASV0893      1.484826e-04  1.551835e-04  1.621699e-04  1.694522e-04
## ASV11060    -1.484682e-04 -1.551678e-04 -1.621527e-04 -1.694334e-04
## ASV3207      5.157131e-04  5.398814e-04  5.651622e-04  5.916045e-04
## ASV3498     -1.484666e-04 -1.551660e-04 -1.621508e-04 -1.694314e-04
## ASV4358      9.424782e-05  9.853410e-05  1.030058e-04  1.076701e-04
## ASV4806      2.553810e-04  2.670176e-04  2.791594e-04  2.918261e-04
## ASV4941      1.484587e-04  1.551574e-04  1.621414e-04  1.694212e-04
## ASV6998      4.455364e-05  4.657916e-05  4.869182e-05  5.089489e-05
## ASV7327     -1.484477e-04 -1.551454e-04 -1.621282e-04 -1.694068e-04
## ASV5112      3.016855e-04  3.156743e-04  3.302924e-04  3.455659e-04
## ASV5345     -1.484212e-04 -1.551164e-04 -1.620966e-04 -1.693722e-04
## ASV8911     -1.484068e-04 -1.551007e-04 -1.620794e-04 -1.693535e-04
## ASV5061      3.474058e-04  3.632202e-04  3.797201e-04  3.969320e-04
## ASV1968     -3.135791e-05 -3.297425e-05 -3.467821e-05 -3.647482e-05
## ASV4669     -1.483803e-04 -1.550717e-04 -1.620478e-04 -1.693190e-04
## ASV6209     -5.411121e-05 -5.635097e-05 -5.866702e-05 -6.106036e-05
## ASV6938      2.945771e-04  3.077742e-04  3.215239e-04  3.358456e-04
## ASV6987      1.626593e-04  1.697057e-04  1.770252e-04  1.846255e-04
## ASV7842     -1.483732e-04 -1.550640e-04 -1.620394e-04 -1.693098e-04
## ASV17950     1.108171e-07  1.194041e-07  1.285367e-07  1.382309e-07
## ASV3380     -4.314654e-04 -4.507424e-04 -4.708230e-04 -4.917354e-04
## ASV13740    -3.702122e-04 -3.873126e-04 -4.051782e-04 -4.238408e-04
## ASV4313     -2.169765e-04 -2.269491e-04 -2.373628e-04 -2.482355e-04
## ASV3891     -2.219220e-04 -2.313250e-04 -2.410752e-04 -2.511810e-04
## ASV3322     -2.623756e-04 -2.743907e-04 -2.869342e-04 -3.000275e-04
## ASV1668     -4.577187e-05 -4.799834e-05 -5.033623e-05 -5.279148e-05
## ASV1739      1.002094e-04  1.045135e-04  1.089811e-04  1.136165e-04
## ASV3194      2.088206e-04  2.183274e-04  2.282469e-04  2.385953e-04
## ASV0071     -3.104263e-04 -3.236655e-04 -3.374011e-04 -3.516456e-04
## ASV0695      1.523686e-04  1.594900e-04  1.669342e-04  1.747146e-04
## ASV3835     -1.179418e-04 -1.231754e-04 -1.286237e-04 -1.342940e-04
## ASV1876      1.231084e-04  1.288586e-04  1.348712e-04  1.411575e-04
## ASV4892     -3.643410e-04 -3.810877e-04 -3.985761e-04 -4.168364e-04
## ASV1212     -1.252341e-04 -1.309263e-04 -1.368654e-04 -1.430612e-04
## ASV2640      1.365381e-06  1.348027e-06  1.322735e-06  1.288554e-06
## ASV7236     -3.606588e-04 -3.773417e-04 -3.947733e-04 -4.129849e-04
## ASV2353     -1.016523e-04 -1.065215e-04 -1.116246e-04 -1.169727e-04
## ASV0276      4.339895e-04  4.530249e-04  4.728245e-04  4.934133e-04
## ASV2262     -1.332963e-04 -1.393844e-04 -1.457401e-04 -1.523745e-04
## ASV11201    -9.006844e-05 -9.435756e-05 -9.884999e-05 -1.035552e-04
## ASV0665      3.569605e-05  3.726516e-05  3.889830e-05  4.059776e-05
## ASV5238      3.304750e-05  3.384342e-05  3.461021e-05  3.534117e-05
## ASV6885     -1.972280e-04 -2.061668e-04 -2.154901e-04 -2.252127e-04
## ASV1844      8.222061e-05  8.639863e-05  9.079744e-05  9.542916e-05
## ASV0379      2.572389e-04  2.688938e-04  2.810493e-04  2.937244e-04
## ASV1040     -7.959548e-05 -8.301072e-05 -8.655570e-05 -9.023389e-05
## ASV7913     -1.495048e-04 -1.563335e-04 -1.634602e-04 -1.708966e-04
## ASV1197     -2.571940e-04 -2.688448e-04 -2.809958e-04 -2.936660e-04
## ASV5918      1.118408e-04  1.169997e-04  1.223890e-04  1.280182e-04
## ASV8045      5.905012e-05  6.201749e-05  6.513819e-05  6.842025e-05
## ASV16458    -2.474605e-05 -2.564628e-05 -2.656462e-05 -2.749984e-05
## ASV10827    -2.571763e-04 -2.688256e-04 -2.809749e-04 -2.936432e-04
## ASV3658     -2.571513e-04 -2.687983e-04 -2.809451e-04 -2.936107e-04
## ASV0073     -5.355694e-04 -5.602855e-04 -5.861037e-04 -6.130694e-04
## ASV1951     -1.106261e-04 -1.162289e-04 -1.221250e-04 -1.283303e-04
## ASV7630     -3.397423e-04 -3.552228e-04 -3.713761e-04 -3.882287e-04
## ASV9449     -1.827092e-04 -1.913380e-04 -2.003689e-04 -2.098198e-04
## ASV3944      3.644606e-04  3.810101e-04  3.982754e-04  4.162843e-04
## ASV1520     -4.923707e-04 -5.145836e-04 -5.377415e-04 -5.618794e-04
## ASV0307      3.830595e-04  4.008541e-04  4.194540e-04  4.388936e-04
## ASV12731    -9.785932e-05 -1.025480e-04 -1.074624e-04 -1.126133e-04
## ASV0282      3.845914e-04  4.024563e-04  4.211297e-04  4.406460e-04
## ASV2646      3.405746e-04  3.555006e-04  3.710220e-04  3.871573e-04
## ASV3536      2.732988e-04  2.858039e-04  2.988573e-04  3.124807e-04
## ASV10089    -2.492882e-04 -2.602138e-04 -2.715754e-04 -2.833867e-04
## ASV1185      2.492648e-04  2.601883e-04  2.715477e-04  2.833565e-04
## ASV1452      2.492413e-04  2.601628e-04  2.715199e-04  2.833263e-04
## ASV1700      2.492179e-04  2.601373e-04  2.714922e-04  2.832961e-04
## ASV6948     -2.491945e-04 -2.601118e-04 -2.714644e-04 -2.832659e-04
## ASV0389     -3.258242e-04 -3.402165e-04 -3.551932e-04 -3.707735e-04
## ASV11884     4.992430e-06  5.646094e-06  6.365373e-06  7.155942e-06
## ASV23165    -2.491436e-04 -2.600564e-04 -2.714041e-04 -2.832003e-04
## ASV2841      2.491202e-04  2.600309e-04  2.713764e-04  2.831701e-04
## ASV2949      2.490968e-04  2.600055e-04  2.713486e-04  2.831399e-04
## ASV4037      2.490735e-04  2.599800e-04  2.713209e-04  2.831098e-04
## ASV4477      2.490501e-04  2.599545e-04  2.712932e-04  2.830796e-04
## ASV4496      2.490267e-04  2.599291e-04  2.712655e-04  2.830495e-04
## ASV5784     -2.490034e-04 -2.599036e-04 -2.712378e-04 -2.830193e-04
## ASV6035      7.676818e-06  8.303539e-06  8.982040e-06  9.716441e-06
## ASV6232     -2.494295e-04 -2.603483e-04 -2.717017e-04 -2.835032e-04
## ASV1818      2.489577e-04  2.598539e-04  2.711837e-04  2.829605e-04
## ASV2595      2.489343e-04  2.598285e-04  2.711560e-04  2.829304e-04
## ASV2788     -3.278286e-05 -3.423811e-05 -3.575283e-05 -3.732896e-05
## ASV5018      2.489130e-04  2.598052e-04  2.711307e-04  2.829028e-04
## ASV0127      3.414864e-04  3.573213e-04  3.738703e-04  3.911636e-04
## ASV1527      8.537306e-06  9.047174e-06  9.589685e-06  1.016698e-05
## ASV1055      1.929767e-04  2.017565e-04  2.109163e-04  2.204707e-04
## ASV4791      1.199733e-04  1.245268e-04  1.291970e-04  1.339816e-04
## ASV0859      1.373327e-04  1.434507e-04  1.498208e-04  1.564514e-04
## ASV12971    -3.683815e-04 -3.852519e-04 -4.028629e-04 -4.212439e-04
## ASV16856    -3.683454e-04 -3.852124e-04 -4.028196e-04 -4.211966e-04
## ASV7321     -3.010628e-04 -3.148767e-04 -3.292994e-04 -3.443554e-04
## ASV8780     -3.682804e-04 -3.851413e-04 -4.027419e-04 -4.211116e-04
## ASV1569      2.694745e-04  2.817352e-04  2.945274e-04  3.078718e-04
## ASV3696      4.294057e-05  4.479151e-05  4.671285e-05  4.870639e-05
## ASV0624      4.927705e-04  5.151268e-04  5.384488e-04  5.627743e-04
## ASV0495      2.993931e-04  3.127495e-04  3.266602e-04  3.411447e-04
## ASV16971    -1.504140e-04 -1.572933e-04 -1.644741e-04 -1.719683e-04
## ASV6535      8.689873e-05  9.113193e-05  9.557446e-05  1.002369e-04
## ASV1897      3.516213e-04  3.673704e-04  3.837800e-04  4.008738e-04
## ASV2631     -4.729147e-05 -4.980927e-05 -5.247011e-05 -5.528269e-05
## ASV6204      1.190528e-04  1.245939e-04  1.303861e-04  1.364400e-04
## ASV3312     -2.272380e-04 -2.376946e-04 -2.486162e-04 -2.600219e-04
## ASV3360      1.447747e-04  1.516115e-04  1.587671e-04  1.662559e-04
## ASV3907      7.054429e-05  7.391877e-05  7.745426e-05  8.115834e-05
## ASV6090      7.201465e-05  7.533732e-05  7.880733e-05  8.243058e-05
## ASV8652     -8.183698e-05 -8.538445e-05 -8.906975e-05 -9.289680e-05
## ASV11129    -1.484289e-04 -1.551308e-04 -1.621189e-04 -1.694041e-04
## ASV11073    -1.484145e-04 -1.551150e-04 -1.621017e-04 -1.693854e-04
## ASV1840      4.964186e-04  5.187403e-04  5.420044e-04  5.662450e-04
## ASV2298      1.868169e-04  1.951105e-04  2.037458e-04  2.127346e-04
## ASV2420      4.466913e-04  4.671765e-04  4.885648e-04  5.108927e-04
## ASV6474      6.167957e-05  6.462787e-05  6.771607e-05  7.095060e-05
## ASV8475     -1.483956e-04 -1.550944e-04 -1.620792e-04 -1.693609e-04
## ASV8679     -1.483812e-04 -1.550787e-04 -1.620620e-04 -1.693421e-04
## ASV6527      1.424878e-04  1.491385e-04  1.560933e-04  1.633654e-04
## ASV2504     -2.474699e-05 -2.609899e-05 -2.753010e-05 -2.904524e-05
## ASV1093     -1.578754e-04 -1.650638e-04 -1.725636e-04 -1.803867e-04
## ASV0994      2.081685e-04  2.177026e-04  2.276558e-04  2.380449e-04
## ASV0092     -3.449160e-04 -3.610269e-04 -3.778745e-04 -3.954911e-04
## ASV2619      7.837414e-05  8.204510e-05  8.588448e-05  8.989964e-05
## ASV0121      4.294104e-04  4.480861e-04  4.674940e-04  4.876555e-04
## ASV0932      1.507098e-04  1.578696e-04  1.653663e-04  1.732153e-04
## ASV5229      2.481722e-04  2.592682e-04  2.708266e-04  2.828637e-04
## ASV6737      2.546508e-04  2.663613e-04  2.785904e-04  2.913593e-04
## ASV11213    -3.558924e-04 -3.716136e-04 -3.879731e-04 -4.049918e-04
## ASV1151      7.392344e-04  7.729018e-04  8.080314e-04  8.446802e-04
## ASV3813      3.839941e-04  4.010742e-04  4.188583e-04  4.373705e-04
## ASV5566      8.312565e-05  8.751443e-05  9.214901e-05  9.704397e-05
## ASV7529     -3.558413e-04 -3.715579e-04 -3.879125e-04 -4.049260e-04
## ASV2193      5.192430e-04  5.433228e-04  5.684881e-04  5.947852e-04
## ASV2349      4.761618e-04  4.980088e-04  5.208207e-04  5.446367e-04
## ASV2387      4.139827e-04  4.321956e-04  4.511412e-04  4.708427e-04
## ASV2699      3.501544e-04  3.666298e-04  3.838703e-04  4.019102e-04
## ASV3353      4.524179e-04  4.728567e-04  4.941674e-04  5.163827e-04
## ASV3621      2.392515e-04  2.497423e-04  2.606520e-04  2.719935e-04
## ASV3848      4.341363e-05  4.549914e-05  4.768522e-05  4.997670e-05
## ASV4440      7.675916e-06  8.409028e-06  9.208689e-06  1.008056e-05
## ASV4751      4.787001e-04  5.006595e-04  5.235875e-04  5.475234e-04
## ASV5115      2.059201e-04  2.155123e-04  2.255399e-04  2.360215e-04
## ASV5850     -3.557520e-04 -3.714606e-04 -3.878064e-04 -4.048103e-04
## ASV6293      2.219322e-04  2.320862e-04  2.426853e-04  2.537470e-04
## ASV6513      9.975413e-05  1.047067e-04  1.099121e-04  1.153836e-04
## ASV7628     -3.557246e-04 -3.714307e-04 -3.877739e-04 -4.047750e-04
## ASV7658      2.203767e-04  2.306613e-04  2.414136e-04  2.526534e-04
## ASV0776     -4.194871e-04 -4.381836e-04 -4.576537e-04 -4.779242e-04
## ASV10227    -3.556945e-04 -3.713980e-04 -3.877383e-04 -4.047362e-04
## ASV11965    -3.556609e-04 -3.713613e-04 -3.876983e-04 -4.046927e-04
## ASV1270     -1.194172e-04 -1.245110e-04 -1.297945e-04 -1.352723e-04
## ASV13123    -2.679896e-04 -2.797148e-04 -2.919058e-04 -3.045768e-04
## ASV5828      3.555950e-04  3.712895e-04  3.876202e-04  4.046077e-04
## ASV5920     -3.555613e-04 -3.712529e-04 -3.875802e-04 -4.045641e-04
## ASV6071      3.419299e-04  3.577667e-04  3.743162e-04  3.916089e-04
## ASV6723     -1.566768e-05 -1.612491e-05 -1.657913e-05 -1.702826e-05
## ASV6727     -3.555190e-04 -3.712067e-04 -3.875299e-04 -4.045094e-04
## ASV7759     -3.554854e-04 -3.711701e-04 -3.874900e-04 -4.044659e-04
## ASV0733      2.569111e-05  2.694702e-05  2.826635e-05  2.965253e-05
## ASV1655     -5.629243e-05 -5.923326e-05 -6.233656e-05 -6.561186e-05
## ASV0755     -5.308668e-04 -5.546118e-04 -5.793493e-04 -6.051147e-04
## ASV0796      2.131725e-04  2.221586e-04  2.314706e-04  2.411157e-04
## ASV0878      4.621566e-04  4.831770e-04  5.051078e-04  5.279843e-04
## ASV4988     -2.870187e-04 -3.000963e-04 -3.137421e-04 -3.279782e-04
## ASV0083     -3.291949e-04 -3.444757e-04 -3.604444e-04 -3.771297e-04
## ASV0273      1.513047e-04  1.576688e-04  1.642647e-04  1.710979e-04
## ASV3076      1.085733e-04  1.136634e-04  1.189879e-04  1.245572e-04
## ASV1513      8.815672e-05  9.211455e-05  9.623879e-05  1.005354e-04
## ASV5159     -2.131952e-05 -2.210589e-05 -2.291013e-05 -2.373157e-05
## ASV3422     -2.191642e-04 -2.292959e-04 -2.398819e-04 -2.509411e-04
## ASV12230    -3.036870e-05 -3.160089e-05 -3.287275e-05 -3.418456e-05
## ASV1694      4.491252e-04  4.691250e-04  4.899549e-04  5.116442e-04
## ASV1249      1.982596e-04  2.073434e-04  2.168260e-04  2.267235e-04
## ASV1697     -1.087715e-04 -1.136167e-04 -1.186626e-04 -1.239162e-04
## ASV4408     -2.632617e-04 -2.743860e-04 -2.859197e-04 -2.978727e-04
## ASV0095     -3.406331e-04 -3.566445e-04 -3.733974e-04 -3.909248e-04
## ASV0410     -1.667925e-07 -4.190971e-07 -7.053149e-07 -1.028922e-06
## ASV4642     -4.231914e-04 -4.426148e-04 -4.628953e-04 -4.840677e-04
## ASV4560     -2.958025e-07 -4.486976e-08  2.414232e-07  5.667102e-07
## ASV7586     -1.996650e-04 -2.088832e-04 -2.185127e-04 -2.285706e-04
## ASV4144     -2.251491e-04 -2.356330e-04 -2.465933e-04 -2.580505e-04
## ASV0327     -2.423078e-04 -2.532672e-04 -2.646956e-04 -2.766106e-04
## ASV0946     -2.016171e-04 -2.102378e-04 -2.191846e-04 -2.284666e-04
## ASV3254     -2.636054e-04 -2.758502e-04 -2.886486e-04 -3.020242e-04
## ASV0349      3.796935e-04  3.971552e-04  4.153902e-04  4.344300e-04
## ASV0472     -2.305458e-04 -2.409792e-04 -2.518595e-04 -2.632033e-04
## ASV1330      2.299666e-04  2.399761e-04  2.503778e-04  2.611831e-04
## ASV2605      2.473559e-04  2.587333e-04  2.706146e-04  2.830202e-04
## ASV2846     -1.426909e-04 -1.495122e-04 -1.566589e-04 -1.641463e-04
## ASV3982     -1.157415e-04 -1.211945e-04 -1.269014e-04 -1.328734e-04
## ASV4116     -2.635590e-04 -2.757992e-04 -2.885926e-04 -3.019628e-04
## ASV6048     -1.545673e-04 -1.617916e-04 -1.693466e-04 -1.772467e-04
## ASV1146      3.165897e-04  3.310020e-04  3.460388e-04  3.617241e-04
## ASV13362     1.783752e-05  1.852337e-05  1.922731e-05  1.994897e-05
## ASV1422     -2.635246e-04 -2.757615e-04 -2.885513e-04 -3.019175e-04
## ASV3640     -2.634983e-04 -2.757328e-04 -2.885198e-04 -3.018831e-04
## ASV5404      2.035549e-04  2.124633e-04  2.217267e-04  2.313559e-04
## ASV6118     -2.634806e-04 -2.757133e-04 -2.884984e-04 -3.018596e-04
## ASV1115     -2.249186e-04 -2.353623e-04 -2.462768e-04 -2.576822e-04
## ASV0888     -4.797043e-04 -5.016344e-04 -5.245246e-04 -5.484132e-04
## ASV4620      5.769705e-05  5.939646e-05  6.108796e-05  6.276434e-05
## ASV3099      9.560950e-05  1.002243e-04  1.050633e-04  1.101372e-04
## ASV7099      4.452688e-05  4.669518e-05  4.897038e-05  5.135776e-05
## ASV5892     -3.022170e-04 -3.160721e-04 -3.305373e-04 -3.456370e-04
## ASV6978     -3.017871e-04 -3.157920e-04 -3.304297e-04 -3.457271e-04
## ASV6555     -1.056269e-04 -1.111322e-04 -1.169397e-04 -1.230668e-04
## ASV0539     -3.779955e-04 -3.950616e-04 -4.128552e-04 -4.314037e-04
## ASV4665      1.041636e-04  1.085158e-04  1.130219e-04  1.176850e-04
## ASV2210      2.245821e-04  2.341473e-04  2.440738e-04  2.543719e-04
## ASV1329      2.405666e-04  2.517472e-04  2.634330e-04  2.756456e-04
## ASV7123     -3.489341e-04 -3.651113e-04 -3.820184e-04 -3.996863e-04
## ASV1260      2.568242e-06  2.744617e-06  2.934026e-06  3.137455e-06
## ASV1011      3.578206e-04  3.747207e-04  3.924100e-04  4.109241e-04
## ASV4233      9.779993e-05  1.024068e-04  1.072279e-04  1.122727e-04
## ASV1475      3.600778e-04  3.763480e-04  3.933157e-04  4.110077e-04
## ASV6099     -4.169858e-04 -4.358274e-04 -4.554739e-04 -4.759552e-04
## ASV1428      7.369974e-06  8.770309e-06  1.032761e-05  1.205651e-05
## ASV5101     -4.609461e-04 -4.825064e-04 -5.050571e-04 -5.286418e-04
## ASV11827    -2.071015e-04 -2.166257e-04 -2.265719e-04 -2.369576e-04
## ASV13899    -2.354485e-04 -2.462669e-04 -2.575640e-04 -2.693592e-04
## ASV21259    -2.768399e-04 -2.896408e-04 -3.030158e-04 -3.169889e-04
## ASV6635     -1.376061e-04 -1.441226e-04 -1.509455e-04 -1.580888e-04
## ASV9922     -3.708831e-04 -3.879944e-04 -4.058693e-04 -4.245393e-04
## ASV2869      4.515559e-05  4.714348e-05  4.921075e-05  5.135977e-05
## ASV1740      2.409329e-04  2.518004e-04  2.631302e-04  2.749393e-04
## ASV4406     -3.746111e-04 -3.920775e-04 -4.103409e-04 -4.294359e-04
## ASV5586     -3.201085e-04 -3.351672e-04 -3.509249e-04 -3.674133e-04
## ASV3255     -1.260257e-04 -1.317520e-04 -1.377258e-04 -1.439569e-04
## ASV12281    -1.760863e-04 -1.839343e-04 -1.921086e-04 -2.006207e-04
## ASV5388     -3.462620e-04 -3.615202e-04 -3.773946e-04 -3.939051e-04
## ASV17660    -3.589107e-04 -3.754100e-04 -3.926404e-04 -4.106318e-04
## ASV0159      1.954201e-04  2.039671e-04  2.128584e-04  2.221057e-04
## ASV2734     -5.309079e-04 -5.550562e-04 -5.802507e-04 -6.065323e-04
## ASV2049      4.051643e-05  4.238832e-05  4.434451e-05  4.638863e-05
## ASV2465      2.349126e-05  2.410939e-05  2.471475e-05  2.530352e-05
## ASV2147      1.612996e-04  1.678717e-04  1.746618e-04  1.816729e-04
## ASV3113     -5.093925e-05 -5.320538e-05 -5.556400e-05 -5.801806e-05
## ASV0622     -3.776946e-04 -3.951406e-04 -4.133657e-04 -4.324020e-04
## ASV0437     -3.774678e-04 -3.946495e-04 -4.125763e-04 -4.312770e-04
## ASV6385     -4.138820e-04 -4.329460e-04 -4.528575e-04 -4.736514e-04
## ASV3699     -3.770904e-04 -3.947884e-04 -4.133044e-04 -4.326750e-04
## ASV2208      3.770525e-04  3.947468e-04  4.132588e-04  4.326251e-04
## ASV1053      8.560464e-05  8.950752e-05  9.358096e-05  9.783183e-05
## ASV8468     -8.337497e-05 -8.707619e-05 -9.092936e-05 -9.493959e-05
## ASV0951     -3.138517e-04 -3.280562e-04 -3.428699e-04 -3.583159e-04
## ASV0278      4.472247e-04  4.671305e-04  4.878592e-04  5.094391e-04
## ASV0914     -2.349988e-04 -2.456795e-04 -2.568214e-04 -2.684423e-04
## ASV0737      3.469276e-04  3.618518e-04  3.773475e-04  3.934303e-04
## ASV2038      5.051499e-04  5.277517e-04  5.512989e-04  5.758250e-04
## ASV2171      3.039760e-04  3.169397e-04  3.303891e-04  3.443368e-04
## ASV2607      3.468526e-04  3.617703e-04  3.772588e-04  3.933339e-04
## ASV3143      2.624054e-04  2.734869e-04  2.849734e-04  2.968744e-04
## ASV3187     -3.723812e-04 -3.884497e-04 -4.051379e-04 -4.224636e-04
## ASV3810      3.467637e-04  3.616736e-04  3.771538e-04  3.932198e-04
## ASV5060     -2.125266e-04 -2.214641e-04 -2.307251e-04 -2.403167e-04
## ASV5325      3.467143e-04  3.616200e-04  3.770955e-04  3.931566e-04
## ASV6905     -3.466824e-04 -3.615853e-04 -3.770578e-04 -3.931156e-04
## ASV7597     -3.466505e-04 -3.615506e-04 -3.770201e-04 -3.930747e-04
## ASV9652     -3.466186e-04 -3.615159e-04 -3.769824e-04 -3.930338e-04
## ASV2634      3.465867e-04  3.614813e-04  3.769448e-04  3.929928e-04
## ASV3065      3.465548e-04  3.614466e-04  3.769071e-04  3.929519e-04
## ASV3331      3.465230e-04  3.614120e-04  3.768694e-04  3.929110e-04
## ASV7434     -3.464911e-04 -3.613773e-04 -3.768318e-04 -3.928701e-04
## ASV7720      5.933662e-05  6.270693e-05  6.628295e-05  7.007781e-05
## ASV8414     -3.464627e-04 -3.613465e-04 -3.767984e-04 -3.928340e-04
## ASV12139    -3.464308e-04 -3.613119e-04 -3.767608e-04 -3.927931e-04
## ASV1824      3.374832e-04  3.519557e-04  3.669783e-04  3.825658e-04
## ASV2094      3.420168e-04  3.567018e-04  3.719466e-04  3.877666e-04
## ASV2770     -8.182199e-05 -8.601553e-05 -9.043210e-05 -9.508383e-05
## ASV3505     -1.647452e-04 -1.712636e-04 -1.779778e-04 -1.848880e-04
## ASV1935      3.463283e-04  3.612006e-04  3.766400e-04  3.926621e-04
## ASV5764     -3.462965e-04 -3.611660e-04 -3.766024e-04 -3.926213e-04
## ASV6806      2.251900e-04  2.358009e-04  2.469046e-04  2.585232e-04
## ASV6942     -3.462670e-04 -3.611339e-04 -3.765676e-04 -3.925835e-04
## ASV1166      3.810546e-04  3.975271e-04  4.146380e-04  4.324057e-04
## ASV1664      2.720260e-04  2.840457e-04  2.965534e-04  3.095650e-04
## ASV2568      3.462055e-04  3.610671e-04  3.764949e-04  3.925046e-04
## ASV3525      3.461737e-04  3.610325e-04  3.764574e-04  3.924637e-04
## ASV4965     -4.165904e-04 -4.350024e-04 -4.541644e-04 -4.741015e-04
## ASV6607     -2.122708e-04 -2.209491e-04 -2.299172e-04 -2.391789e-04
## ASV7187      1.183229e-04  1.236221e-04  1.291423e-04  1.348911e-04
## ASV0388     -3.493029e-04 -3.658086e-04 -3.830866e-04 -4.011724e-04
## ASV1420      2.868685e-06  3.130016e-06  3.414280e-06  3.723369e-06
## ASV14293     1.140344e-04  1.195635e-04  1.253637e-04  1.314483e-04
## ASV17785     2.857392e-06  3.117583e-06  3.400592e-06  3.708299e-06
## ASV7678      1.916924e-05  1.944083e-05  1.967072e-05  1.985269e-05
## ASV2253      9.615901e-05  1.008068e-04  1.056809e-04  1.107923e-04
## ASV4150      1.894174e-04  1.977023e-04  2.063173e-04  2.152729e-04
## ASV3836     -4.410321e-04 -4.610984e-04 -4.820352e-04 -5.038765e-04
## ASV16231    -3.633929e-04 -3.803257e-04 -3.980302e-04 -4.165398e-04
## ASV2730      7.326097e-06  7.667626e-06  8.025137e-06  8.399420e-06
## ASV2072      2.031090e-04  2.117708e-04  2.207574e-04  2.300770e-04
## ASV2160      5.634187e-05  5.925169e-05  6.231993e-05  6.555576e-05
## ASV5013      6.582447e-05  6.848832e-05  7.123645e-05  7.406919e-05
## ASV2586      1.201683e-04  1.255608e-04  1.311791e-04  1.370314e-04
## ASV1442      9.469305e-05  9.904665e-05  1.035908e-04  1.083328e-04
## ASV3101      1.322231e-04  1.376423e-04  1.432418e-04  1.490236e-04
## ASV3323     -1.130861e-04 -1.184011e-04 -1.239552e-04 -1.297576e-04
## ASV1812      3.412882e-04  3.559215e-04  3.711108e-04  3.868712e-04
## ASV6120     -4.171602e-05 -4.385685e-05 -4.611242e-05 -4.848915e-05
## ASV2565      7.441172e-05  7.758600e-05  8.087921e-05  8.429438e-05
## ASV6687      3.848002e-05  4.018298e-05  4.195534e-05  4.379937e-05
## ASV5357     -3.021306e-04 -3.159180e-04 -3.303062e-04 -3.453188e-04
## ASV9383      1.490901e-04  1.556133e-04  1.623963e-04  1.694474e-04
## ASV11753    -2.584787e-04 -2.702471e-04 -2.825260e-04 -2.953354e-04
## ASV11512    -7.166379e-05 -7.492358e-05 -7.832481e-05 -8.187301e-05
## ASV2791     -1.196175e-05 -1.266824e-05 -1.342012e-05 -1.422046e-05
## ASV0664     -5.460098e-04 -5.707035e-04 -5.964530e-04 -6.232980e-04
## ASV3436      5.803669e-05  6.110106e-05  6.433853e-05  6.775971e-05
## ASV5755      3.714283e-04  3.881282e-04  4.055331e-04  4.236685e-04
## ASV10970    -3.660001e-04 -3.826488e-04 -4.000180e-04 -4.181355e-04
## ASV11798    -1.867097e-04 -1.951940e-04 -2.040449e-04 -2.132762e-04
## ASV18193    -3.659487e-04 -3.825926e-04 -3.999566e-04 -4.180684e-04
## ASV2548      3.836668e-04  4.007848e-04  4.186154e-04  4.371837e-04
## ASV3901      4.147025e-04  4.332082e-04  4.524845e-04  4.725587e-04
## ASV5197      5.362489e-06  5.099137e-06  4.781095e-06  4.402760e-06
## ASV5859      1.841660e-04  1.924068e-04  2.009933e-04  2.099380e-04
## ASV6240     -3.659280e-04 -3.825699e-04 -3.999317e-04 -4.180412e-04
## ASV7281      3.658923e-04  3.825309e-04  3.998891e-04  4.179946e-04
## ASV7635      2.060411e-04  2.155341e-04  2.254488e-04  2.358025e-04
## ASV8822     -3.658637e-04 -3.824996e-04 -3.998549e-04 -4.179572e-04
## ASV4810     -7.664323e-05 -7.984074e-05 -8.314917e-05 -8.657018e-05
## ASV5308      3.829381e-04  4.003796e-04  4.185785e-04  4.375644e-04
## ASV2749     -4.198972e-04 -4.391719e-04 -4.592974e-04 -4.803079e-04
## ASV0298      3.418967e-05  3.629986e-05  3.855226e-05  4.095696e-05
## ASV2597     -3.939467e-04 -4.120942e-04 -4.310486e-04 -4.508430e-04
## ASV5758     -1.638449e-04 -1.713362e-04 -1.791561e-04 -1.873177e-04
## ASV9987     -4.158994e-04 -4.349383e-04 -4.548130e-04 -4.755568e-04
## ASV0971      8.214034e-05  8.540496e-05  8.877274e-05  9.224483e-05
## ASV0627     -4.065832e-04 -4.253532e-04 -4.449616e-04 -4.654432e-04
## ASV1758      3.674737e-04  3.842013e-04  4.016548e-04  4.198627e-04
## ASV4559      1.835260e-06  1.985346e-06  2.147296e-06  2.321947e-06
## ASV11400    -1.451197e-05 -1.497959e-05 -1.544907e-05 -1.591868e-05
## ASV11559    -3.703088e-04 -3.873686e-04 -4.051874e-04 -4.237967e-04
## ASV3943     -3.702723e-04 -3.873286e-04 -4.051436e-04 -4.237488e-04
## ASV10389     6.825957e-05  7.114294e-05  7.413032e-05  7.722376e-05
## ASV5168      3.249936e-04  3.393453e-04  3.542798e-04  3.698163e-04
## ASV5724      2.286425e-04  2.391952e-04  2.502186e-04  2.617319e-04
## ASV6337      7.034343e-05  7.318053e-05  7.610723e-05  7.912399e-05
## ASV11063     2.047056e-04  2.135261e-04  2.226853e-04  2.321927e-04
## ASV4279     -3.942968e-05 -4.122685e-05 -4.310205e-05 -4.505831e-05
## ASV7660     -1.538766e-04 -1.610804e-04 -1.686152e-04 -1.764959e-04
## ASV8218     -1.538612e-04 -1.610635e-04 -1.685967e-04 -1.764756e-04
## ASV3574      6.028867e-04  6.309349e-04  6.602563e-04  6.909055e-04
## ASV12050    -1.538641e-04 -1.610666e-04 -1.686001e-04 -1.764793e-04
## ASV3897      1.359667e-04  1.419356e-04  1.481439e-04  1.545995e-04
## ASV3856     -4.616516e-04 -4.826961e-04 -5.046548e-04 -5.275632e-04
## ASV3024     -1.475135e-04 -1.546422e-04 -1.621157e-04 -1.699504e-04
## ASV8715     -3.592058e-04 -3.756077e-04 -3.927260e-04 -4.105888e-04
## ASV6917     -1.499041e-04 -1.562152e-04 -1.627553e-04 -1.695299e-04
## ASV1132      3.732736e-04  3.906881e-04  4.088980e-04  4.279381e-04
## ASV3583      1.881301e-04  1.970065e-04  2.062976e-04  2.160223e-04
## ASV0328      5.936835e-04  6.208956e-04  6.493066e-04  6.789650e-04
## ASV0915     -1.998618e-04 -2.092309e-04 -2.190322e-04 -2.292852e-04
## ASV2677      2.026183e-04  2.122273e-04  2.222886e-04  2.328229e-04
## ASV0599      2.025014e-04  2.115258e-04  2.209263e-04  2.307166e-04
## ASV0283     -5.405867e-04 -5.651786e-04 -5.908364e-04 -6.176017e-04
## ASV1028      2.249815e-04  2.355137e-04  2.465296e-04  2.580506e-04
## ASV0523      4.088525e-04  4.277622e-04  4.475194e-04  4.681594e-04
## ASV8201     -2.492721e-04 -2.608324e-04 -2.729127e-04 -2.855349e-04
## ASV2795     -7.785153e-05 -8.136728e-05 -8.503318e-05 -8.885490e-05
## ASV3563     -7.772688e-05 -8.123666e-05 -8.489631e-05 -8.871147e-05
## ASV1553     -1.404353e-04 -1.464374e-04 -1.526660e-04 -1.591271e-04
## ASV7155     -4.169495e-05 -4.410438e-05 -4.666033e-05 -4.937168e-05
## ASV0365      5.209339e-04  5.444591e-04  5.689894e-04  5.945629e-04
## ASV8583     -3.581666e-04 -3.743499e-04 -3.912240e-04 -4.088149e-04
## ASV5400      1.931284e-05  2.025435e-05  2.124125e-05  2.227555e-05
## ASV5908      2.756075e-04  2.876976e-04  3.002705e-04  3.133411e-04
## ASV2075      1.575511e-04  1.648573e-04  1.724924e-04  1.804701e-04
## ASV2520     -3.143471e-04 -3.289480e-04 -3.442094e-04 -3.601599e-04
## ASV9596     -1.528127e-04 -1.594572e-04 -1.663623e-04 -1.735357e-04
## ASV1131     -5.007862e-05 -5.200649e-05 -5.398845e-05 -5.602429e-05
## ASV0579     -1.017355e-04 -1.063264e-04 -1.111135e-04 -1.161041e-04
## ASV0288     -4.973931e-04 -5.197492e-04 -5.430502e-04 -5.673308e-04
## ASV4053      8.019513e-05  8.333017e-05  8.655600e-05  8.987233e-05
## ASV1736     -2.662313e-04 -2.783489e-04 -2.909917e-04 -3.041799e-04
## ASV1254      2.725549e-04  2.845616e-04  2.970541e-04  3.100485e-04
## ASV9038     -4.364611e-04 -4.565188e-04 -4.774628e-04 -4.993289e-04
## ASV4746      3.992651e-04  4.178874e-04  4.373600e-04  4.577201e-04
## ASV5803      1.509845e-04  1.579187e-04  1.651595e-04  1.727194e-04
## ASV0525      1.751176e-05  1.836153e-05  1.925302e-05  2.018828e-05
## ASV1974      2.280235e-04  2.379664e-04  2.483006e-04  2.590377e-04
## ASV1827      3.832936e-04  4.003179e-04  4.180428e-04  4.364923e-04
## ASV30780     1.821973e-05  1.887675e-05  1.954604e-05  2.022657e-05
## ASV9342      1.501305e-05  1.589854e-05  1.684149e-05  1.784595e-05
## ASV21626    -3.636571e-04 -3.801231e-04 -3.972946e-04 -4.151982e-04
## ASV1232     -2.568028e-04 -2.683161e-04 -2.803130e-04 -2.928110e-04
## ASV5578     -2.604211e-04 -2.723705e-04 -2.848470e-04 -2.978718e-04
## ASV5868      2.712950e-04  2.831855e-04  2.955522e-04  3.084104e-04
## ASV13625    -1.127250e-04 -1.177555e-04 -1.229946e-04 -1.284495e-04
## ASV3614      4.109399e-05  4.273899e-05  4.443534e-05  4.618330e-05
## ASV2128      2.357264e-04  2.466520e-04  2.580690e-04  2.699983e-04
## ASV5086      5.106894e-05  5.331414e-05  5.564905e-05  5.807644e-05
## ASV6614     -2.604068e-04 -2.723548e-04 -2.848298e-04 -2.978529e-04
## ASV9451     -2.603812e-04 -2.723268e-04 -2.847991e-04 -2.978194e-04
## ASV9533     -2.603555e-04 -2.722988e-04 -2.847685e-04 -2.977859e-04
## ASV10697     3.966554e-06  4.334292e-06  4.735231e-06  5.172244e-06
## ASV1473     -1.207687e-04 -1.259692e-04 -1.313685e-04 -1.369720e-04
## ASV1414     -7.753455e-05 -8.116569e-05 -8.496193e-05 -8.893016e-05
## ASV1567     -7.698320e-05 -8.084480e-05 -8.490750e-05 -8.918230e-05
## ASV6395     -2.630338e-04 -2.752322e-04 -2.879810e-04 -3.013036e-04
## ASV2366      1.035416e-04  1.077676e-04  1.121323e-04  1.166371e-04
## ASV2537      1.036678e-04  1.080013e-04  1.124884e-04  1.171322e-04
## ASV5378     -2.630208e-04 -2.752177e-04 -2.879650e-04 -3.012859e-04
## ASV5929     -2.767677e-04 -2.895889e-04 -3.029874e-04 -3.169874e-04
## ASV6360      2.178532e-04  2.274718e-04  2.374797e-04  2.478891e-04
## ASV7916     -4.540893e-05 -4.772909e-05 -5.017420e-05 -5.275148e-05
## ASV13322     8.793088e-05  9.216736e-05  9.660926e-05  1.012666e-04
## ASV6207     -3.318550e-04 -3.469960e-04 -3.627966e-04 -3.792828e-04
## ASV8823     -2.644342e-04 -2.765805e-04 -2.892634e-04 -3.025047e-04
## ASV1379      3.677383e-04  3.845513e-04  4.021000e-04  4.204136e-04
## ASV3259     -3.677023e-04 -3.845119e-04 -4.020569e-04 -4.203665e-04
## ASV18748     1.737997e-06  2.005727e-06  2.302977e-06  2.632610e-06
## ASV3570      8.011996e-05  8.383016e-05  8.770698e-05  9.175741e-05
## ASV0790     -7.632487e-05 -7.897815e-05 -8.167496e-05 -8.441102e-05
## ASV5149     -3.354564e-04 -3.506372e-04 -3.664678e-04 -3.829726e-04
## ASV1730     -3.465074e-04 -3.622637e-04 -3.787014e-04 -3.958469e-04
## ASV3488     -2.802737e-05 -2.919918e-05 -3.041272e-05 -3.166885e-05
## ASV5486     -3.777626e-04 -3.955284e-04 -4.141193e-04 -4.335725e-04
## ASV1319      5.614022e-05  5.785514e-05  5.957104e-05  6.128182e-05
## ASV15328    -2.584118e-04 -2.701773e-04 -2.824535e-04 -2.952604e-04
## ASV5994      3.733398e-04  3.903926e-04  4.081903e-04  4.267621e-04
## ASV4992     -2.958072e-05 -3.082808e-05 -3.212041e-05 -3.345863e-05
## ASV1788     -4.053406e-04 -4.231204e-04 -4.416126e-04 -4.608398e-04
## ASV3264     -3.763820e-06 -3.672628e-06 -3.553189e-06 -3.402162e-06
## ASV4895      1.711959e-05  1.778171e-05  1.846173e-05  1.915935e-05
## ASV9218     -5.529190e-06 -5.503550e-06 -5.451237e-06 -5.368869e-06
## ASV0736     -8.816889e-06 -9.477459e-06 -1.019050e-05 -1.096024e-05
## ASV0916      2.583514e-04  2.701115e-04  2.823819e-04  2.951824e-04
## ASV15761    -2.583262e-04 -2.700839e-04 -2.823517e-04 -2.951495e-04
## ASV4191      3.207945e-04  3.350708e-04  3.499368e-04  3.654130e-04
## ASV3268     -6.525393e-05 -6.800403e-05 -7.085286e-05 -7.380236e-05
## ASV15321    -4.295147e-05 -4.514903e-05 -4.746454e-05 -4.990468e-05
## ASV0708     -2.590240e-04 -2.710754e-04 -2.836740e-04 -2.968434e-04
## ASV4100      2.971760e-05  3.086334e-05  3.203991e-05  3.324681e-05
## ASV1627      2.049288e-04  2.135431e-04  2.224709e-04  2.317194e-04
## ASV7045     -2.288281e-04 -2.393157e-04 -2.502637e-04 -2.616905e-04
## ASV3271      5.248719e-05  5.422892e-05  5.599325e-05  5.777708e-05
## ASV6200     -4.015904e-05 -4.209439e-05 -4.412440e-05 -4.625385e-05
## ASV2727     -2.717148e-04 -2.846114e-04 -2.981144e-04 -3.122514e-04
## ASV3523     -3.570274e-04 -3.731959e-04 -3.900576e-04 -4.076385e-04
## ASV2259      2.412335e-04  2.522392e-04  2.637250e-04  2.757097e-04
## ASV0181      3.536988e-04  3.696074e-04  3.861888e-04  4.034677e-04
## ASV1680      7.096790e-04  7.419226e-04  7.755589e-04  8.106416e-04
## ASV0176      7.149503e-05  7.454075e-05  7.769893e-05  8.097207e-05
## ASV10458    -2.595685e-04 -2.714404e-04 -2.838325e-04 -2.967656e-04
## ASV10658    -2.595431e-04 -2.714125e-04 -2.838020e-04 -2.967323e-04
## ASV16807    -2.595176e-04 -2.713847e-04 -2.837716e-04 -2.966991e-04
## ASV2113     -2.594922e-04 -2.713569e-04 -2.837412e-04 -2.966658e-04
## ASV2403      2.654362e-04  2.773730e-04  2.898140e-04  3.027774e-04
## ASV2484     -2.594816e-04 -2.713452e-04 -2.837284e-04 -2.966518e-04
## ASV8876     -2.594561e-04 -2.713174e-04 -2.836980e-04 -2.966186e-04
## ASV0386      3.805451e-04  3.982275e-04  4.167104e-04  4.360283e-04
## ASV0351      1.040184e-04  1.085765e-04  1.133156e-04  1.182413e-04
## ASV4942     -1.476889e-04 -1.543962e-04 -1.613937e-04 -1.686929e-04
## ASV5128     -1.148598e-04 -1.201934e-04 -1.257676e-04 -1.315925e-04
## ASV3496      1.299762e-04  1.363173e-04  1.429731e-04  1.499598e-04
## ASV3329      3.786147e-04  3.961494e-04  4.144722e-04  4.336164e-04
## ASV7878     -2.583872e-04 -2.701450e-04 -2.824121e-04 -2.952083e-04
## ASV8251     -9.814334e-05 -1.026046e-04 -1.072584e-04 -1.121119e-04
## ASV15958    -8.507051e-05 -8.900960e-05 -9.312539e-05 -9.742527e-05
## ASV7972     -3.700818e-04 -3.871142e-04 -4.049023e-04 -4.234772e-04
## ASV2088      3.700453e-04  3.870742e-04  4.048586e-04  4.234294e-04
## ASV3054     -1.741925e-04 -1.822112e-04 -1.905854e-04 -1.993296e-04
## ASV4494     -3.699942e-04 -3.870183e-04 -4.047975e-04 -4.233625e-04
## ASV0087     -6.998044e-04 -7.315834e-04 -7.647336e-04 -7.993077e-04
## ASV1614     -2.860171e-04 -2.989795e-04 -3.124983e-04 -3.265947e-04
## ASV3037     -1.586314e-04 -1.658731e-04 -1.734308e-04 -1.813170e-04
## ASV6615     -4.241608e-05 -4.458668e-05 -4.687327e-05 -4.928232e-05
## ASV1027      1.070881e-04  1.118650e-04  1.168397e-04  1.220191e-04
## ASV2754     -6.802665e-05 -7.139566e-05 -7.493572e-05 -7.865574e-05
## ASV0536     -5.290435e-05 -5.546267e-05 -5.814568e-05 -6.095948e-05
## ASV2318     -1.115488e-04 -1.167984e-04 -1.222921e-04 -1.280408e-04
## ASV5954      2.187387e-04  2.282565e-04  2.381483e-04  2.484254e-04
## ASV9028      1.553311e-04  1.624603e-04  1.699038e-04  1.776743e-04
## ASV6600     -2.631580e-04 -2.753650e-04 -2.881229e-04 -3.014550e-04
## ASV1923     -6.876866e-05 -7.180982e-05 -7.497413e-05 -7.826550e-05
## ASV4034     -5.206179e-05 -5.480540e-05 -5.770234e-05 -6.076172e-05
## ASV9933     -2.631214e-04 -2.753250e-04 -2.880790e-04 -3.014070e-04
## ASV1575      4.853680e-05  5.057231e-05  5.268166e-05  5.486663e-05
## ASV7812     -4.459233e-04 -4.662279e-04 -4.874133e-04 -5.095136e-04
## ASV0515      2.858137e-04  2.984663e-04  3.116350e-04  3.253370e-04
## ASV1149     -3.430869e-05 -3.636279e-05 -3.854977e-05 -4.087860e-05
## ASV3791      1.206720e-04  1.263726e-04  1.323399e-04  1.385861e-04
## ASV4065     -4.172224e-04 -4.362622e-04 -4.561311e-04 -4.768618e-04
## ASV10631    -2.444915e-05 -2.580030e-05 -2.723260e-05 -2.875133e-05
## ASV2359     -4.094052e-04 -4.272414e-04 -4.457816e-04 -4.650476e-04
## ASV3206     -2.598166e-04 -2.717153e-04 -2.841373e-04 -2.971036e-04
## ASV4415      2.114809e-04  2.211611e-04  2.312655e-04  2.418109e-04
## ASV4467     -1.858257e-04 -1.942217e-04 -2.029763e-04 -2.121030e-04
## ASV5598      3.201220e-04  3.352206e-04  3.510241e-04  3.675647e-04
## ASV5910     -2.867379e-04 -2.998970e-04 -3.136373e-04 -3.279823e-04
## ASV9494     -2.597471e-04 -2.716393e-04 -2.840542e-04 -2.970127e-04
## ASV6548     -2.119692e-04 -2.216304e-04 -2.317121e-04 -2.422311e-04
## ASV8669     -2.597012e-04 -2.715891e-04 -2.839993e-04 -2.969527e-04
## ASV0674      1.601929e-04  1.671692e-04  1.744188e-04  1.819496e-04
## ASV0061     -8.100645e-05 -8.559345e-05 -9.045845e-05 -9.561897e-05
## ASV0310     -1.597146e-04 -1.667637e-04 -1.741032e-04 -1.817436e-04
## ASV0582      4.846855e-05  5.038734e-05  5.236419e-05  5.439920e-05
## ASV0739      4.931443e-04  5.160078e-04  5.399005e-04  5.648657e-04
## ASV1557      2.067165e-04  2.165192e-04  2.267836e-04  2.375312e-04
## ASV0146      4.563059e-04  4.763000e-04  4.970923e-04  5.187078e-04
## ASV3832      4.673766e-04  4.882441e-04  5.099791e-04  5.326119e-04
## ASV0734      1.053377e-04  1.102595e-04  1.154053e-04  1.207848e-04
## ASV3036     -3.447524e-04 -3.607645e-04 -3.775013e-04 -3.949940e-04
## ASV0240      9.204842e-05  9.615168e-05  1.004250e-04  1.048741e-04
## ASV2513     -5.148040e-04 -5.379866e-04 -5.621521e-04 -5.873366e-04
## ASV1118     -1.383217e-04 -1.448885e-04 -1.517636e-04 -1.589609e-04
## ASV7286     -2.588905e-04 -2.706987e-04 -2.830213e-04 -2.958785e-04
## ASV1077      3.447110e-04  3.601217e-04  3.761761e-04  3.928969e-04
## ASV1255     -2.588362e-04 -2.706394e-04 -2.829566e-04 -2.958079e-04
## ASV1794     -1.585729e-05 -1.662636e-05 -1.743293e-05 -1.827882e-05
## ASV2439     -2.588120e-04 -2.706130e-04 -2.829277e-04 -2.957763e-04
## ASV2467     -2.587867e-04 -2.705853e-04 -2.828974e-04 -2.957432e-04
## ASV3346     -2.587614e-04 -2.705577e-04 -2.828672e-04 -2.957102e-04
## ASV3973     -2.587361e-04 -2.705300e-04 -2.828370e-04 -2.956772e-04
## ASV4521      1.138641e-04  1.189259e-04  1.241953e-04  1.296791e-04
## ASV1909     -3.089920e-04 -3.234656e-04 -3.386051e-04 -3.544399e-04
## ASV3855     -2.315396e-04 -2.419895e-04 -2.528842e-04 -2.642403e-04
## ASV0810      3.098697e-04  3.241050e-04  3.389696e-04  3.544887e-04
## ASV1765      3.701177e-04  3.872892e-04  4.052358e-04  4.239905e-04
## ASV0763      2.005779e-04  2.097039e-04  2.192253e-04  2.291576e-04
## ASV0302     -2.181526e-04 -2.279196e-04 -2.380950e-04 -2.486935e-04
## ASV2643     -2.958627e-04 -3.087721e-04 -3.221948e-04 -3.361473e-04
## ASV0440      1.161358e-04  1.215781e-04  1.272692e-04  1.332198e-04
## ASV4899     -2.083163e-04 -2.174221e-04 -2.268882e-04 -2.367253e-04
## ASV0287     -1.277662e-04 -1.336896e-04 -1.398808e-04 -1.463513e-04
## ASV3220      1.600306e-04  1.674876e-04  1.752828e-04  1.834305e-04
## ASV1007     -9.093122e-05 -9.486246e-05 -9.894497e-05 -1.031829e-04
## ASV2929     -5.757614e-05 -5.994233e-05 -6.238815e-05 -6.491464e-05
## ASV1496     -2.206416e-04 -2.309657e-04 -2.417638e-04 -2.530568e-04
## ASV4975      9.619271e-05  1.006259e-04  1.052555e-04  1.100892e-04
## ASV4392     -1.228506e-05 -1.256162e-05 -1.282321e-05 -1.306668e-05
## ASV4653     -2.622475e-04 -2.743698e-04 -2.870352e-04 -3.002666e-04
## ASV0230     -1.345726e-04 -1.408782e-04 -1.474738e-04 -1.543720e-04
## ASV0840      1.891271e-04  1.978497e-04  2.069614e-04  2.164785e-04
## ASV4132     -5.691821e-05 -5.965912e-05 -6.253281e-05 -6.554571e-05
## ASV3344      1.959009e-04  2.046119e-04  2.136821e-04  2.231240e-04
## ASV12096    -2.661294e-04 -2.784730e-04 -2.913719e-04 -3.048492e-04
## ASV1550      8.703802e-05  9.059900e-05  9.427872e-05  9.807867e-05
## ASV3542     -3.951888e-04 -4.136776e-04 -4.330117e-04 -4.532273e-04
## ASV8795     -1.527733e-04 -1.598688e-04 -1.672848e-04 -1.750350e-04
## ASV2532     -8.545113e-06 -9.026684e-06 -9.537662e-06 -1.007997e-05
## ASV3087      6.256004e-05  6.527749e-05  6.810103e-05  7.103375e-05
## ASV9476     -1.527625e-04 -1.598569e-04 -1.672717e-04 -1.750206e-04
## ASV13721    -1.527472e-04 -1.598402e-04 -1.672535e-04 -1.750006e-04
## ASV3842      2.496545e-04  2.607182e-04  2.722343e-04  2.842182e-04
## ASV1663      4.494363e-04  4.693741e-04  4.901298e-04  5.117311e-04
## ASV0432      1.056163e-04  1.102920e-04  1.151586e-04  1.202223e-04
## ASV4356      4.465398e-04  4.668611e-04  4.880634e-04  5.101811e-04
## ASV4524      1.095024e-04  1.147296e-04  1.202060e-04  1.259433e-04
## ASV0169     -2.215437e-04 -2.319250e-04 -2.427836e-04 -2.541405e-04
## ASV0368     -1.903881e-04 -1.992989e-04 -2.086182e-04 -2.183640e-04
## ASV2603      8.092536e-08  8.081551e-08  7.962100e-08  7.709809e-08
## ASV3777      2.502708e-04  2.617471e-04  2.737287e-04  2.862357e-04
## ASV3978      2.167177e-04  2.264955e-04  2.366886e-04  2.473122e-04
## ASV0413     -1.796279e-04 -1.880279e-04 -1.968123e-04 -2.059979e-04
## ASV0997     -3.957536e-08 -3.558674e-08 -3.015765e-08 -2.301290e-08
## ASV1195     -3.958160e-08 -3.559610e-08 -3.017100e-08 -2.303130e-08
## ASV2522     -1.176749e-04 -1.230366e-04 -1.286314e-04 -1.344683e-04
## ASV4733      2.152645e-04  2.251649e-04  2.355035e-04  2.462979e-04
## ASV1063      3.790450e-04  3.969244e-04  4.156383e-04  4.352247e-04
## ASV0612     -4.822489e-04 -5.047054e-04 -5.281843e-04 -5.527300e-04
## ASV1903     -3.789618e-04 -3.968332e-04 -4.155384e-04 -4.351152e-04
## ASV3576     -1.114140e-04 -1.169466e-04 -1.227625e-04 -1.288766e-04
## ASV4285     -2.695634e-04 -2.821323e-04 -2.952734e-04 -3.090111e-04
## ASV3406     -1.399247e-04 -1.463773e-04 -1.531177e-04 -1.601579e-04
## ASV2379     -2.571257e-04 -2.681941e-04 -2.796877e-04 -2.916184e-04
## ASV0528      3.286281e-04  3.437785e-04  3.596029e-04  3.761289e-04
## ASV6190     -4.312793e-05 -4.523315e-05 -4.744262e-05 -4.976156e-05
## ASV1537     -2.877462e-06 -2.860944e-06 -2.829398e-06 -2.780830e-06
## ASV16780    -2.916215e-04 -3.048795e-04 -3.187114e-04 -3.331394e-04
## ASV0477      7.250907e-04  7.583057e-04  7.929808e-04  8.291745e-04
## ASV1499      1.681712e-04  1.764525e-04  1.851492e-04  1.942824e-04
## ASV14736     1.255483e-04  1.312249e-04  1.371448e-04  1.433172e-04
## ASV0179     -1.048338e-04 -1.097027e-04 -1.147917e-04 -1.201101e-04
## ASV3153      1.020440e-05  1.104824e-05  1.196429e-05  1.295870e-05
## ASV0266      3.394128e-04  3.551162e-04  3.715253e-04  3.886700e-04
## ASV0761      5.006239e-04  5.232585e-04  5.468621e-04  5.714712e-04
## ASV0269     -5.050925e-05 -5.316395e-05 -5.596752e-05 -5.892899e-05
## ASV7259     -9.653645e-05 -1.013559e-04 -1.064217e-04 -1.117466e-04
## ASV2067     -1.055796e-04 -1.102220e-04 -1.150511e-04 -1.200730e-04
## ASV2985     -2.976327e-04 -3.112698e-04 -3.255043e-04 -3.403596e-04
## ASV0975     -4.518953e-04 -4.727921e-04 -4.946253e-04 -5.174342e-04
## ASV2240      2.669534e-04  2.787967e-04  2.911270e-04  3.039611e-04
## ASV2297      8.577590e-05  8.930181e-05  9.294742e-05  9.671457e-05
## ASV2657      1.120004e-04  1.168872e-04  1.219679e-04  1.272487e-04
## ASV3784      4.835676e-06  5.279361e-06  5.762400e-06  6.288096e-06
## ASV4333      4.834763e-06  5.278319e-06  5.761212e-06  6.286741e-06
## ASV5547      2.292702e-04  2.391271e-04  2.493620e-04  2.599855e-04
## ASV5813      9.315907e-05  9.719392e-05  1.013854e-04  1.057381e-04
## ASV8049      1.122942e-04  1.173281e-04  1.225738e-04  1.280392e-04
## ASV8661     -4.848262e-06 -5.293000e-06 -5.777172e-06 -6.304086e-06
## ASV9510      1.310927e-04  1.369337e-04  1.430166e-04  1.493498e-04
## ASV1401      6.869954e-05  7.172989e-05  7.488334e-05  7.816401e-05
## ASV1417     -1.355573e-04 -1.411034e-04 -1.468354e-04 -1.527560e-04
## ASV2169      4.800787e-04  5.019489e-04  5.247702e-04  5.485801e-04
## ASV5354     -4.865351e-06 -5.311672e-06 -5.797569e-06 -6.326362e-06
## ASV5379     -4.864433e-06 -5.310624e-06 -5.796374e-06 -6.324999e-06
## ASV6078     -4.863515e-06 -5.309577e-06 -5.795180e-06 -6.323638e-06
## ASV6417      2.926353e-04  3.057391e-04  3.193917e-04  3.336127e-04
## ASV8304      2.113639e-04  2.206325e-04  2.302720e-04  2.402941e-04
## ASV8766     -4.892661e-06 -5.341331e-06 -5.829764e-06 -6.361293e-06
## ASV10861     8.804018e-05  9.183770e-05  9.578084e-05  9.987357e-05
## ASV2057      4.748542e-04  4.965162e-04  5.191221e-04  5.427091e-04
## ASV4499      1.647067e-04  1.717244e-04  1.790036e-04  1.865507e-04
## ASV7415      5.278510e-05  5.522638e-05  5.777595e-05  6.043808e-05
## ASV2475     -2.038415e-04 -2.132085e-04 -2.229905e-04 -2.332044e-04
## ASV3517     -3.346083e-04 -3.502760e-04 -3.666646e-04 -3.838060e-04
## ASV1864      2.225635e-04  2.324794e-04  2.428055e-04  2.535560e-04
## ASV2756      2.578726e-04  2.695873e-04  2.818080e-04  2.945543e-04
## ASV0778      2.578475e-04  2.695598e-04  2.817780e-04  2.945216e-04
## ASV3201      6.031026e-05  6.344564e-05  6.675333e-05  7.024342e-05
## ASV3358      2.578264e-04  2.695368e-04  2.817529e-04  2.944942e-04
## ASV5681     -2.578013e-04 -2.695093e-04 -2.817229e-04 -2.944614e-04
## ASV7256      1.252930e-04  1.310915e-04  1.371526e-04  1.434878e-04
## ASV1704     -2.632062e-04 -2.750585e-04 -2.874122e-04 -3.002854e-04
## ASV4445      4.115766e-04  4.294562e-04  4.480369e-04  4.673399e-04
## ASV8649     -2.577502e-04 -2.694536e-04 -2.816621e-04 -2.943951e-04
## ASV0597      2.678628e-04  2.800164e-04  2.926936e-04  3.059146e-04
## ASV0861      3.404376e-04  3.557230e-04  3.716524e-04  3.882491e-04
## ASV2423      4.133261e-04  4.319676e-04  4.514008e-04  4.716550e-04
## ASV1548      1.997214e-04  2.082531e-04  2.171046e-04  2.262839e-04
## ASV2564      3.432388e-04  3.585195e-04  3.744305e-04  3.909933e-04
## ASV2999      5.706002e-04  5.959111e-04  6.222601e-04  6.496821e-04
## ASV4543     -2.077580e-04 -2.174805e-04 -2.276501e-04 -2.382866e-04
## ASV8452      1.953454e-04  2.038712e-04  2.127335e-04  2.219424e-04
## ASV17287    -4.239615e-05 -4.460209e-05 -4.692978e-05 -4.938644e-05
## ASV3503     -2.659713e-04 -2.784466e-04 -2.914979e-04 -3.051511e-04
## ASV4727     -4.684038e-05 -4.933564e-05 -5.197296e-05 -5.476100e-05
## ASV5995     -2.262096e-04 -2.367999e-04 -2.478775e-04 -2.594639e-04
## ASV1665     -7.242006e-05 -7.580441e-05 -7.934368e-05 -8.304466e-05
## ASV2690     -3.372567e-04 -3.527098e-04 -3.688429e-04 -3.856835e-04
## ASV2823     -2.714881e-05 -2.832125e-05 -2.953910e-05 -3.080370e-05
## ASV5241     -4.509341e-04 -4.715854e-04 -4.931430e-04 -5.156431e-04
## ASV5473     -1.303529e-04 -1.365330e-04 -1.430044e-04 -1.497805e-04
## ASV2785      5.906653e-05  6.192417e-05  6.492119e-05  6.806438e-05
## ASV6645     -1.901967e-04 -1.988165e-04 -2.078064e-04 -2.171803e-04
## ASV0562      7.587543e-05  7.904491e-05  8.232463e-05  8.571627e-05
## ASV1163      7.813550e-05  8.178240e-05  8.559529e-05  8.958124e-05
## ASV1825      1.462643e-04  1.527799e-04  1.595642e-04  1.666265e-04
## ASV3795      3.238064e-04  3.384520e-04  3.537251e-04  3.696497e-04
## ASV3869     -7.364623e-05 -7.724470e-05 -8.102251e-05 -8.498887e-05
## ASV4330      2.499393e-04  2.613226e-04  2.731999e-04  2.855906e-04
## ASV6754      9.499719e-05  9.931931e-05  1.038284e-04  1.085315e-04
## ASV4598     -3.093533e-06 -3.386439e-06 -3.706577e-06 -4.056405e-06
## ASV2100      1.908824e-04  1.992947e-04  2.080474e-04  2.171515e-04
## ASV3518      9.482390e-05  9.898566e-05  1.033131e-04  1.078112e-04
## ASV3823      3.943376e-04  4.120559e-04  4.305220e-04  4.497630e-04
## ASV7357      2.423939e-04  2.533779e-04  2.648339e-04  2.767798e-04
## ASV7403     -3.095090e-04 -3.234604e-04 -3.380043e-04 -3.531625e-04
## ASV2934     -1.282452e-05 -1.329102e-05 -1.376673e-05 -1.425096e-05
## ASV5277     -1.611021e-04 -1.683578e-04 -1.759206e-04 -1.838018e-04
## ASV0281     -4.750687e-04 -4.965809e-04 -5.190170e-04 -5.424122e-04
## ASV11181    -1.783215e-04 -1.868423e-04 -1.957717e-04 -2.051294e-04
## ASV0254     -5.951516e-05 -6.164157e-05 -6.380603e-05 -6.600497e-05
## ASV0201     -8.331043e-05 -8.740172e-05 -9.169894e-05 -9.621285e-05
## ASV3656     -2.060618e-04 -2.160124e-04 -2.264483e-04 -2.373936e-04
## ASV7994     -3.677930e-04 -3.846340e-04 -4.022150e-04 -4.205654e-04
## ASV3584     -1.170642e-04 -1.218202e-04 -1.267339e-04 -1.318074e-04
## ASV2157      3.763239e-04  3.930825e-04  4.105361e-04  4.287089e-04
## ASV2935     -4.869591e-05 -5.093505e-05 -5.327334e-05 -5.571482e-05
## ASV9024     -3.432517e-04 -3.586518e-04 -3.746994e-04 -3.914179e-04
## ASV7711      2.072180e-04  2.169769e-04  2.271900e-04  2.378776e-04
## ASV11330    -2.614025e-04 -2.734478e-04 -2.860294e-04 -2.991697e-04
## ASV1875      2.300037e-04  2.405176e-04  2.514929e-04  2.629484e-04
## ASV5861      1.732926e-04  1.814591e-04  1.900054e-04  1.989488e-04
## ASV11562     1.524131e-05  1.597573e-05  1.674537e-05  1.755187e-05
## ASV18559    -2.613941e-04 -2.734386e-04 -2.860194e-04 -2.991587e-04
## ASV4384      2.539290e-04  2.658644e-04  2.783528e-04  2.914189e-04
## ASV1302      5.118487e-04  5.343022e-04  5.576580e-04  5.819454e-04
## ASV4673     -3.438398e-04 -3.598098e-04 -3.765010e-04 -3.939439e-04
## ASV1956      5.629923e-05  5.857870e-05  6.093504e-05  6.336974e-05
## ASV3286      2.403225e-04  2.516285e-04  2.634587e-04  2.758366e-04
## ASV4866     -3.767292e-04 -3.943971e-04 -4.128810e-04 -4.322172e-04
## ASV3129     -1.845960e-04 -1.931822e-04 -2.021586e-04 -2.115421e-04
## ASV4104      4.229191e-04  4.422055e-04  4.623315e-04  4.833302e-04
## ASV8983      3.449534e-06  3.607582e-06  3.773195e-06  3.946821e-06
## ASV2201      1.604767e-04  1.674513e-04  1.746987e-04  1.822269e-04
## ASV3055      1.090440e-04  1.135742e-04  1.182630e-04  1.231134e-04
## ASV0534     -5.502268e-04 -5.750530e-04 -6.009349e-04 -6.279117e-04
## ASV1019      1.938814e-05  2.051603e-05  2.171566e-05  2.299194e-05
## ASV18482    -2.559047e-04 -2.674349e-04 -2.794543e-04 -2.919810e-04
## ASV2694      8.429048e-05  8.780032e-05  9.143361e-05  9.519268e-05
## ASV3412     -7.792997e-05 -8.123975e-05 -8.467088e-05 -8.822598e-05
## ASV4174     -2.558740e-04 -2.674014e-04 -2.794178e-04 -2.919411e-04
## ASV4281     -2.558492e-04 -2.673744e-04 -2.793883e-04 -2.919089e-04
## ASV4949      2.862277e-04  2.988902e-04  3.120695e-04  3.257828e-04
## ASV5881      1.347783e-04  1.408150e-04  1.471043e-04  1.536552e-04
## ASV6299     -1.129532e-04 -1.179016e-04 -1.230468e-04 -1.283948e-04
## ASV0676      2.933313e-04  3.064387e-04  3.200935e-04  3.343153e-04
## ASV1066     -1.998426e-04 -2.087021e-04 -2.179238e-04 -2.275195e-04
## ASV1300     -1.711906e-04 -1.788519e-04 -1.868331e-04 -1.951454e-04
## ASV6455      8.383905e-05  8.767528e-05  9.167989e-05  9.585964e-05
## ASV3455     -2.558420e-04 -2.673665e-04 -2.793797e-04 -2.918996e-04
## ASV6531     -2.558173e-04 -2.673395e-04 -2.793502e-04 -2.918674e-04
## ASV0490      5.102087e-04  5.328424e-04  5.564099e-04  5.809441e-04
## ASV2588      2.975259e-05  3.160472e-05  3.358223e-05  3.569402e-05
## ASV5364      1.609630e-04  1.681702e-04  1.756786e-04  1.834987e-04
## ASV0981     -3.590989e-04 -3.757601e-04 -3.931731e-04 -4.113699e-04
## ASV1563     -7.377148e-05 -7.720513e-05 -8.079530e-05 -8.454886e-05
## ASV0376     -3.445136e-04 -3.604895e-04 -3.771848e-04 -3.946299e-04
## ASV7308     -2.287623e-06 -2.509207e-06 -2.752125e-06 -3.018409e-06
## ASV4817      5.410291e-05  5.630925e-05  5.858767e-05  6.093880e-05
## ASV8716     -3.596143e-04 -3.749105e-04 -3.907794e-04 -4.072362e-04
## ASV1849      4.598239e-04  4.797354e-04  5.004198e-04  5.218994e-04
## ASV9423     -3.575489e-04 -3.736054e-04 -3.903394e-04 -4.077754e-04
## ASV7690      1.370854e-05  1.438478e-05  1.509447e-05  1.583919e-05
## ASV4901      1.983897e-04  2.075409e-04  2.170999e-04  2.270835e-04
## ASV1830     -6.529053e-05 -6.882267e-05 -7.255949e-05 -7.651361e-05
## ASV2316     -2.636308e-04 -2.748914e-04 -2.865805e-04 -2.987102e-04
## ASV0693      3.972760e-04  4.155134e-04  4.345555e-04  4.544350e-04
## ASV1243     -2.070343e-05 -2.133188e-05 -2.195919e-05 -2.258279e-05
## ASV3867      1.049777e-04  1.098942e-04  1.150365e-04  1.204144e-04
## ASV7932      2.251567e-04  2.354698e-04  2.462354e-04  2.574716e-04
## ASV12608     1.641138e-04  1.719725e-04  1.802084e-04  1.888397e-04
## ASV1661      2.353295e-04  2.459938e-04  2.571159e-04  2.687131e-04
## ASV3957      2.482694e-04  2.597355e-04  2.717151e-04  2.842297e-04
## ASV0830     -3.900718e-04 -4.077122e-04 -4.261079e-04 -4.452877e-04
## ASV2078      4.437601e-04  4.640199e-04  4.851657e-04  5.072329e-04
## ASV13932    -2.624099e-04 -2.745491e-04 -2.872332e-04 -3.004851e-04
## ASV5300     -2.623839e-04 -2.745206e-04 -2.872020e-04 -3.004510e-04
## ASV1014     -1.404515e-04 -1.467923e-04 -1.534027e-04 -1.602925e-04
## ASV13059    -8.263087e-05 -8.682107e-05 -9.123164e-05 -9.587455e-05
## ASV4340      5.285861e-05  5.517507e-05  5.758476e-05  6.009076e-05
## ASV5591     -4.349280e-04 -4.545707e-04 -4.750511e-04 -4.964005e-04
## ASV6040     -3.480175e-04 -3.638134e-04 -3.802897e-04 -3.974726e-04
## ASV3904     -1.449721e-04 -1.517740e-04 -1.588895e-04 -1.663324e-04
## ASV2267     -4.077931e-05 -4.265228e-05 -4.460742e-05 -4.664791e-05
## ASV0573     -3.237723e-04 -3.379859e-04 -3.527693e-04 -3.681404e-04
## ASV0851     -3.511302e-04 -3.670647e-04 -3.836849e-04 -4.010168e-04
## ASV7805      1.108277e-04  1.160915e-04  1.216042e-04  1.273774e-04
## ASV3379      4.679570e-04  4.887571e-04  5.104165e-04  5.329648e-04
## ASV0825      2.143076e-04  2.244547e-04  2.350773e-04  2.461970e-04
## ASV2461      2.453713e-04  2.563943e-04  2.678827e-04  2.798539e-04
## ASV2783      3.430811e-04  3.586433e-04  3.748755e-04  3.918033e-04
## ASV0925      3.830629e-04  4.001196e-04  4.178812e-04  4.363721e-04
## ASV7023     -3.673283e-04 -3.842746e-04 -4.019768e-04 -4.204660e-04
## ASV5319      6.698469e-05  7.012653e-05  7.341208e-05  7.684745e-05
## ASV3213      2.293665e-04  2.399684e-04  2.510443e-04  2.626137e-04
## ASV3748     -5.786239e-05 -6.075484e-05 -6.379738e-05 -6.699819e-05
## ASV5491     -8.443744e-05 -8.855049e-05 -9.286767e-05 -9.739939e-05
## ASV7931      1.443562e-04  1.509971e-04  1.579319e-04  1.651724e-04
## ASV12767    -2.638540e-04 -2.761291e-04 -2.889616e-04 -3.023756e-04
## ASV6389      2.657111e-04  2.780266e-04  2.908969e-04  3.043455e-04
## ASV14867    -2.638273e-04 -2.760998e-04 -2.889296e-04 -3.023406e-04
## ASV5105      1.541002e-04  1.613837e-04  1.690076e-04  1.769873e-04
## ASV15927    -2.627653e-04 -2.749351e-04 -2.876523e-04 -3.009399e-04
## ASV2004      8.985142e-05  9.391289e-05  9.814861e-05  1.025653e-04
## ASV5554     -7.267048e-06 -8.190430e-06 -9.207176e-06 -1.032560e-05
## ASV10929    -1.839152e-04 -1.924424e-04 -2.013545e-04 -2.106680e-04
## ASV12778    -9.061418e-05 -9.478232e-05 -9.913551e-05 -1.036814e-04
## ASV14006    -2.627067e-04 -2.748709e-04 -2.875819e-04 -3.008628e-04
## ASV1603      2.570519e-04  2.690100e-04  2.815109e-04  2.945783e-04
## ASV11948     1.310314e-04  1.367621e-04  1.427196e-04  1.489107e-04
## ASV12912    -2.641401e-04 -2.764399e-04 -2.892991e-04 -3.027420e-04
## ASV13147    -2.641137e-04 -2.764110e-04 -2.892675e-04 -3.027074e-04
## ASV14761    -2.640874e-04 -2.763821e-04 -2.892359e-04 -3.026727e-04
## ASV8521      2.093843e-04  2.185870e-04  2.281581e-04  2.381090e-04
## ASV8581     -2.640696e-04 -2.763627e-04 -2.892145e-04 -3.026493e-04
## ASV9875     -4.583821e-05 -4.816071e-05 -5.060625e-05 -5.318171e-05
## ASV9986      1.753467e-04  1.835952e-04  1.922261e-04  2.012563e-04
## ASV2376      3.051311e-04  3.190105e-04  3.334911e-04  3.485962e-04
## ASV17535    -2.640510e-04 -2.763422e-04 -2.891920e-04 -3.026246e-04
## ASV14330    -2.535700e-04 -2.648893e-04 -2.766795e-04 -2.889572e-04
## ASV1333     -5.227025e-04 -5.452881e-04 -5.687480e-04 -5.931073e-04
## ASV2498      1.271649e-04  1.333236e-04  1.397820e-04  1.465546e-04
## ASV6352     -1.030286e-04 -1.074864e-04 -1.121171e-04 -1.169255e-04
## ASV8601     -1.295665e-04 -1.353224e-04 -1.413153e-04 -1.475534e-04
## ASV9776     -9.603979e-05 -1.001265e-04 -1.043647e-04 -1.087580e-04
## ASV1916      2.248446e-04  2.348937e-04  2.453631e-04  2.562681e-04
## ASV1555      2.900861e-05  3.049099e-05  3.205269e-05  3.369819e-05
## ASV2499      3.562749e-04  3.727874e-04  3.900435e-04  4.080747e-04
## ASV0703      2.931490e-04  3.066234e-04  3.206949e-04  3.353879e-04
## ASV2047      3.881458e-04  4.058070e-04  4.242341e-04  4.434568e-04
## ASV5492     -2.650987e-04 -2.774930e-04 -2.904560e-04 -3.040129e-04
## ASV6549     -2.739016e-05 -2.876478e-05 -3.021150e-05 -3.173436e-05
## ASV7757     -9.516433e-05 -9.989045e-05 -1.048587e-04 -1.100822e-04
## ASV0173     -2.678260e-06 -2.928170e-06 -3.200859e-06 -3.498325e-06
## ASV1248     -7.929750e-05 -8.274428e-05 -8.632514e-05 -9.004384e-05
## ASV6502      2.684789e-06  2.935251e-06  3.208533e-06  3.506637e-06
## ASV9844      2.684275e-06  2.934663e-06  3.207861e-06  3.505869e-06
## ASV3903      1.690097e-04  1.769396e-04  1.852356e-04  1.939140e-04
## ASV8199      2.670637e-06  2.919692e-06  3.191425e-06  3.487826e-06
## ASV3309     -1.162294e-05 -1.209478e-05 -1.258135e-05 -1.308262e-05
## ASV5826     -3.928115e-05 -4.122380e-05 -4.326463e-05 -4.540868e-05
## ASV1480     -3.546996e-04 -3.712904e-04 -3.886426e-04 -4.067899e-04
## ASV3090      7.487091e-05  7.823358e-05  8.173795e-05  8.538913e-05
## ASV0758     -2.126528e-04 -2.218433e-04 -2.313896e-04 -2.413020e-04
## ASV0811     -6.419565e-05 -6.698685e-05 -6.988755e-05 -7.290102e-05
## ASV2653      1.761613e-04  1.845057e-04  1.932418e-04  2.023875e-04
## ASV0978      1.822125e-04  1.908626e-04  1.999189e-04  2.093998e-04
## ASV6640     -3.665192e-04 -3.832804e-04 -4.007761e-04 -4.190356e-04
## ASV3423     -1.761126e-05 -1.865922e-05 -1.977648e-05 -2.096808e-05
## ASV0617      3.635687e-04  3.792457e-04  3.955301e-04  4.124398e-04
## ASV14947    -3.709547e-04 -3.880624e-04 -4.059317e-04 -4.245942e-04
## ASV18367    -2.046290e-04 -2.144409e-04 -2.247226e-04 -2.354961e-04
## ASV4574      2.811168e-04  2.933049e-04  3.059665e-04  3.191150e-04
## ASV10514    -1.984319e-04 -2.076984e-04 -2.173880e-04 -2.275191e-04
## ASV11779    -1.012085e-04 -1.064858e-04 -1.120512e-04 -1.179209e-04
## ASV7528     -3.213160e-04 -3.363241e-04 -3.520168e-04 -3.684237e-04
## ASV13153    -1.851221e-04 -1.938487e-04 -2.029810e-04 -2.125371e-04
## ASV7858     -1.643869e-04 -1.721344e-04 -1.802420e-04 -1.887257e-04
## ASV8722      5.476640e-05  5.695068e-05  5.920180e-05  6.151986e-05
## ASV6585     -3.701399e-04 -3.872031e-04 -4.050254e-04 -4.236380e-04
## ASV3311     -3.196704e-04 -3.336125e-04 -3.481034e-04 -3.631595e-04
## ASV2469      5.833357e-06  6.244097e-06  6.684477e-06  7.156520e-06
## ASV11340    -1.589775e-04 -1.659778e-04 -1.732607e-04 -1.808353e-04
## ASV1718      2.992880e-05  3.121010e-05  3.253915e-05  3.391707e-05
## ASV2117     -3.675190e-04 -3.845280e-04 -4.023001e-04 -4.208670e-04
## ASV8252     -2.608984e-04 -2.728965e-04 -2.854267e-04 -2.985106e-04
## ASV8533      5.117828e-05  5.351145e-05  5.594624e-05  5.848666e-05
## ASV9507      3.887473e-05  4.048298e-05  4.214631e-05  4.386551e-05
## ASV0706      1.868170e-04  1.957450e-04  2.051003e-04  2.149034e-04
## ASV10312    -2.608704e-04 -2.728658e-04 -2.853930e-04 -2.984737e-04
## ASV10696    -2.608446e-04 -2.728376e-04 -2.853622e-04 -2.984400e-04
## ASV11203    -2.608189e-04 -2.728095e-04 -2.853314e-04 -2.984064e-04
## ASV12147    -6.302531e-05 -6.608251e-05 -6.928997e-05 -7.265520e-05
## ASV4602     -1.703036e-05 -1.800125e-05 -1.903279e-05 -2.012910e-05
## ASV5568      1.405034e-05  1.479412e-05  1.557951e-05  1.640893e-05
## ASV6777      3.340422e-04  3.494323e-04  3.655073e-04  3.822955e-04
## ASV8749     -2.933109e-04 -3.066221e-04 -3.205073e-04 -3.349885e-04
## ASV4780      4.954937e-05  5.160111e-05  5.372281e-05  5.591541e-05
## ASV10116    -4.931161e-05 -5.154600e-05 -5.387699e-05 -5.630841e-05
## ASV2907      2.842631e-04  2.972708e-04  3.108483e-04  3.250182e-04
## ASV5165      3.723190e-04  3.900140e-04  4.085461e-04  4.279545e-04
## ASV6061      2.061959e-04  2.154884e-04  2.251760e-04  2.352733e-04
## ASV8082     -1.285017e-04 -1.344234e-04 -1.406093e-04 -1.470705e-04
## ASV7696     -1.309053e-04 -1.369476e-04 -1.432603e-04 -1.498547e-04
## ASV0550      2.585851e-05  2.694053e-05  2.806198e-05  2.922389e-05
## ASV7745      1.685256e-04  1.765959e-04  1.850530e-04  1.939154e-04
## ASV3607     -3.452879e-06 -3.549485e-06 -3.644723e-06 -3.738040e-06
## ASV3877     -2.535161e-04 -2.648380e-04 -2.766322e-04 -2.889155e-04
## ASV7667     -1.152788e-04 -1.203451e-04 -1.256158e-04 -1.310975e-04
## ASV9293     -9.749007e-05 -1.020463e-04 -1.068102e-04 -1.117908e-04
## ASV11653    -2.534736e-04 -2.647916e-04 -2.765816e-04 -2.888603e-04
## ASV12850     4.169410e-05  4.386211e-05  4.614679e-05  4.855445e-05
## ASV13104     4.725160e-05  4.918780e-05  5.118793e-05  5.325261e-05
## ASV14208    -2.534547e-04 -2.647711e-04 -2.765592e-04 -2.888359e-04
## ASV1552      2.356891e-04  2.468620e-04  2.585600e-04  2.708073e-04
## ASV2501      1.580452e-04  1.649691e-04  1.721696e-04  1.796556e-04
## ASV2893      3.168074e-04  3.314205e-04  3.466838e-04  3.626239e-04
## ASV3084      1.194027e-04  1.247063e-04  1.302294e-04  1.359796e-04
## ASV3599      1.603037e-04  1.673665e-04  1.747142e-04  1.823560e-04
## ASV3868     -2.534561e-04 -2.647727e-04 -2.765612e-04 -2.888382e-04
## ASV3917     -3.416997e-04 -3.570912e-04 -3.731363e-04 -3.898595e-04
## ASV5695      6.465785e-05  6.779773e-05  7.109141e-05  7.454642e-05
## ASV0131      3.272660e-05  3.384663e-05  3.498254e-05  3.613214e-05
## ASV2847      3.066332e-04  3.200983e-04  3.341035e-04  3.486661e-04
## ASV6875     -2.537164e-04 -2.651869e-04 -2.771478e-04 -2.896177e-04
## ASV1547     -5.234707e-04 -5.469145e-04 -5.713406e-04 -5.967843e-04
## ASV1501     -3.298598e-04 -3.448456e-04 -3.604794e-04 -3.767864e-04
## ASV3876      3.678018e-04  3.846204e-04  4.021751e-04  4.204951e-04
## ASV3456     -3.677657e-04 -3.845809e-04 -4.021320e-04 -4.204480e-04
## ASV1194      3.467573e-04  3.626015e-04  3.791382e-04  3.963949e-04
## ASV2135     -4.449420e-04 -4.655435e-04 -4.870706e-04 -5.095625e-04
## ASV1352      3.676656e-04  3.844714e-04  4.020122e-04  4.203170e-04
## ASV3208      4.183369e-04  4.374902e-04  4.574841e-04  4.783522e-04
## ASV1164      4.009567e-06  4.376430e-06  4.775352e-06  5.208939e-06
## ASV3492      1.764324e-04  1.849083e-04  1.937929e-04  2.031060e-04
## ASV1601      2.023134e-04  2.115505e-04  2.211908e-04  2.312502e-04
## ASV5347     -2.586908e-04 -2.702404e-04 -2.822715e-04 -2.948011e-04
## ASV0293      1.954572e-04  2.044104e-04  2.137567e-04  2.235118e-04
## ASV1509      3.370216e-04  3.523886e-04  3.684234e-04  3.851518e-04
## ASV2801      4.881645e-05  5.097834e-05  5.322914e-05  5.557197e-05
## ASV2873     -7.863145e-05 -8.236309e-05 -8.627129e-05 -9.036437e-05
## ASV2162     -5.240097e-05 -5.473584e-05 -5.716781e-05 -5.970033e-05
## ASV0462      2.022640e-04  2.109419e-04  2.199509e-04  2.293003e-04
## ASV5367     -3.194114e-04 -3.341830e-04 -3.496161e-04 -3.657383e-04
## ASV2715      3.981226e-04  4.161051e-04  4.348549e-04  4.544005e-04
## ASV0371      4.869555e-04  5.084347e-04  5.307885e-04  5.540466e-04
## ASV8090     -3.369083e-04 -3.520277e-04 -3.677832e-04 -3.841978e-04
## ASV6320     -2.642835e-04 -2.766017e-04 -2.894817e-04 -3.029481e-04
## ASV2562      2.777073e-04  2.906863e-04  3.042595e-04  3.184529e-04
## ASV1505     -3.890295e-04 -4.070475e-04 -4.258746e-04 -4.455448e-04
## ASV4924     -2.974110e-04 -3.108802e-04 -3.249267e-04 -3.395724e-04
## ASV1437      3.327809e-04  3.479919e-04  3.638688e-04  3.804379e-04
## ASV3816     -2.119073e-05 -2.185665e-05 -2.252596e-05 -2.319676e-05
## ASV1969     -1.624702e-04 -1.703182e-04 -1.785422e-04 -1.871595e-04
## ASV3146      1.759639e-04  1.836969e-04  1.917408e-04  2.001054e-04
## ASV0321     -1.908504e-04 -1.993566e-04 -2.082173e-04 -2.174452e-04
## ASV1020      3.847596e-04  4.019730e-04  4.199071e-04  4.385879e-04
## ASV4138      2.759750e-05  2.906162e-05  3.060788e-05  3.224108e-05
## ASV0329     -2.137502e-04 -2.235891e-04 -2.338637e-04 -2.445915e-04
## ASV10647     3.873455e-05  4.061814e-05  4.259468e-05  4.466884e-05
## ASV3389      3.182678e-04  3.328574e-04  3.480888e-04  3.639879e-04
## ASV6880      1.693984e-04  1.765083e-04  1.838725e-04  1.914960e-04
## ASV2624     -4.419292e-05 -4.664937e-05 -4.925307e-05 -5.201344e-05
## ASV3686     -6.387274e-05 -6.764534e-05 -7.165958e-05 -7.593176e-05
## ASV12302    -2.663047e-04 -2.788108e-04 -2.918958e-04 -3.055856e-04
## ASV1184      3.245588e-04  3.392793e-04  3.546329e-04  3.706434e-04
## ASV3533     -1.377636e-04 -1.435964e-04 -1.496411e-04 -1.559019e-04
## ASV1735      7.663971e-05  7.986210e-05  8.319959e-05  8.665439e-05
## ASV0483     -1.511351e-04 -1.582319e-04 -1.656558e-04 -1.734213e-04
## ASV0928     -2.997686e-04 -3.136318e-04 -3.281167e-04 -3.432494e-04
## ASV12254    -2.631821e-04 -2.753918e-04 -2.881526e-04 -3.014880e-04
## ASV16025    -2.631560e-04 -2.753632e-04 -2.881212e-04 -3.014537e-04
## ASV3070     -2.631298e-04 -2.753345e-04 -2.880899e-04 -3.014193e-04
## ASV1850      6.224236e-05  6.524968e-05  6.840300e-05  7.170933e-05
## ASV8946     -2.574416e-04 -2.691092e-04 -2.812776e-04 -2.939658e-04
## ASV1536      2.156833e-04  2.254137e-04  2.355575e-04  2.461301e-04
## ASV4151      3.242420e-04  3.387849e-04  3.539394e-04  3.697276e-04
## ASV4585      4.353633e-04  4.548813e-04  4.752186e-04  4.964045e-04
## ASV4921     -1.050068e-04 -1.096229e-04 -1.144226e-04 -1.194114e-04
## ASV6172      2.573728e-04  2.690340e-04  2.811955e-04  2.938763e-04
## ASV6375     -2.573477e-04 -2.690067e-04 -2.811657e-04 -2.938437e-04
## ASV6501      2.913922e-04  3.041832e-04  3.174884e-04  3.313243e-04
## ASV17095    -2.573282e-04 -2.689853e-04 -2.811424e-04 -2.938182e-04
## ASV3679     -2.573032e-04 -2.689580e-04 -2.811125e-04 -2.937856e-04
## ASV5750      2.572782e-04  2.689307e-04  2.810827e-04  2.937531e-04
## ASV5922     -2.572532e-04 -2.689034e-04 -2.810529e-04 -2.937205e-04
## ASV7323     -2.572283e-04 -2.688761e-04 -2.810231e-04 -2.936879e-04
## ASV8515     -3.810914e-06 -4.036289e-06 -4.275000e-06 -4.527731e-06
## ASV8753     -2.572029e-04 -2.688484e-04 -2.809928e-04 -2.936549e-04
## ASV9197      1.769308e-04  1.849957e-04  1.934107e-04  2.021893e-04
## ASV1778      4.894792e-05  5.142623e-05  5.403507e-05  5.678163e-05
## ASV1241      3.313468e-04  3.461979e-04  3.616723e-04  3.777924e-04
## ASV1717      2.594496e-04  2.712207e-04  2.834992e-04  2.963047e-04
## ASV1112      2.963158e-04  3.092915e-04  3.227841e-04  3.368098e-04
## ASV3994      3.500434e-04  3.661311e-04  3.829288e-04  4.004649e-04
## ASV5511     -2.587781e-04 -2.705731e-04 -2.828809e-04 -2.957216e-04
## ASV8706      1.892977e-04  1.982546e-04  2.076315e-04  2.174475e-04
## ASV3049     -2.587577e-04 -2.705509e-04 -2.828566e-04 -2.956951e-04
## ASV4332      1.668693e-04  1.746547e-04  1.827947e-04  1.913044e-04
## ASV7411      2.919915e-04  3.049090e-04  3.183528e-04  3.323405e-04
## ASV7475     -2.587473e-04 -2.705394e-04 -2.828442e-04 -2.956815e-04
## ASV8988     -2.587220e-04 -2.705118e-04 -2.828140e-04 -2.956485e-04
## ASV0688     -5.499707e-04 -5.743102e-04 -5.996434e-04 -6.260035e-04
## ASV1946      1.475586e-04  1.538212e-04  1.603155e-04  1.670473e-04
## ASV3150      4.290954e-04  4.483859e-04  4.684904e-04  4.894383e-04
## ASV3508      2.085769e-04  2.176400e-04  2.270573e-04  2.368388e-04
## ASV3863     -2.587040e-04 -2.704920e-04 -2.827923e-04 -2.956248e-04
## ASV4544      2.018103e-04  2.105661e-04  2.196627e-04  2.291098e-04
## ASV4567      4.665119e-04  4.876949e-04  5.097922e-04  5.328388e-04
## ASV4855     -2.586777e-04 -2.704633e-04 -2.827609e-04 -2.955905e-04
## ASV4872      3.440980e-04  3.594937e-04  3.755324e-04  3.922366e-04
## ASV4881      2.497265e-04  2.614306e-04  2.736736e-04  2.864792e-04
## ASV5283      2.586571e-04  2.704408e-04  2.827363e-04  2.955636e-04
## ASV5302      3.050697e-04  3.188589e-04  3.332409e-04  3.482390e-04
## ASV5909      2.593068e-04  2.710586e-04  2.833148e-04  2.960944e-04
## ASV5933      1.937065e-04  2.025217e-04  2.117185e-04  2.213116e-04
## ASV6019      2.846144e-04  2.969958e-04  3.098637e-04  3.232328e-04
## ASV6043      1.159125e-04  1.213872e-04  1.271175e-04  1.331149e-04
## ASV6908      3.239842e-04  3.386761e-04  3.539999e-04  3.699794e-04
## ASV7245     -2.586708e-04 -2.704557e-04 -2.827526e-04 -2.955813e-04
## ASV7249     -2.586455e-04 -2.704281e-04 -2.827224e-04 -2.955484e-04
## ASV8349      8.744386e-05  9.150743e-05  9.575481e-05  1.001938e-04
## ASV7310     -2.586248e-04 -2.704054e-04 -2.826976e-04 -2.955213e-04
## ASV1893      1.999684e-04  2.089359e-04  2.182821e-04  2.280210e-04
## ASV2354      1.525009e-04  1.590002e-04  1.657433e-04  1.727366e-04
## ASV3435     -4.257127e-05 -4.433381e-05 -4.615680e-05 -4.804115e-05
## ASV0480      4.033496e-04  4.221474e-04  4.417987e-04  4.623399e-04
## ASV0955     -1.400988e-04 -1.466285e-04 -1.534559e-04 -1.605940e-04
## ASV10000     7.687273e-05  7.991489e-05  8.304803e-05  8.627211e-05
## ASV7215     -1.681049e-04 -1.759839e-04 -1.842247e-04 -1.928430e-04
## ASV10423    -3.660549e-04 -3.827089e-04 -4.000838e-04 -4.182075e-04
## ASV6008     -1.956651e-04 -2.045946e-04 -2.139130e-04 -2.236357e-04
## ASV9330     -3.660025e-04 -3.826515e-04 -4.000211e-04 -4.181391e-04
## ASV6051      3.659668e-04  3.826125e-04  3.999785e-04  4.180925e-04
## ASV1675      2.418729e-04  2.528586e-04  2.643181e-04  2.762696e-04
## ASV2043      1.577853e-04  1.652117e-04  1.729831e-04  1.811148e-04
## ASV3634      1.490717e-04  1.562545e-04  1.637862e-04  1.716842e-04
## ASV4077     -3.659498e-04 -3.825940e-04 -3.999583e-04 -4.180706e-04
## ASV4754      1.766404e-04  1.845501e-04  1.927910e-04  2.013749e-04
## ASV6095      4.182518e-04  4.368322e-04  4.561792e-04  4.763193e-04
## ASV6288      3.098034e-04  3.236760e-04  3.381288e-04  3.531825e-04
## ASV6507     -3.659278e-04 -3.825700e-04 -3.999321e-04 -4.180419e-04
## ASV8905      1.853643e-04  1.936638e-04  2.023112e-04  2.113190e-04
## ASV9728     -3.658982e-04 -3.825376e-04 -3.998967e-04 -4.180032e-04
## ASV11144    -3.658625e-04 -3.824986e-04 -3.998541e-04 -4.179566e-04
## ASV1615     -1.475950e-04 -1.544154e-04 -1.615403e-04 -1.689823e-04
## ASV2709     -4.460547e-04 -4.662793e-04 -4.873733e-04 -5.093694e-04
## ASV3003      3.547066e-04  3.710540e-04  3.881295e-04  4.059634e-04
## ASV5163     -3.371388e-04 -3.524477e-04 -3.684167e-04 -3.850708e-04
## ASV6622      2.378082e-04  2.488748e-04  2.604439e-04  2.725373e-04
## ASV1076     -3.496119e-04 -3.655967e-04 -3.822810e-04 -3.996926e-04
## ASV7895      8.208864e-05  8.564088e-05  8.932985e-05  9.315921e-05
## ASV10577    -2.661712e-04 -2.786658e-04 -2.917383e-04 -3.054148e-04
## ASV1272      2.661444e-04  2.786364e-04  2.917062e-04  3.053795e-04
## ASV2492     -1.334675e-04 -1.402543e-04 -1.474016e-04 -1.549296e-04
## ASV5195      3.185543e-04  3.331847e-04  3.484621e-04  3.644129e-04
## ASV5267      1.910668e-04  1.996140e-04  2.085174e-04  2.177895e-04
## ASV6317      2.717471e-04  2.843848e-04  2.975949e-04  3.114021e-04
## ASV2296      9.755750e-05  1.020633e-04  1.067717e-04  1.116916e-04
## ASV2290     -2.378304e-04 -2.484060e-04 -2.594183e-04 -2.708823e-04
## ASV3726      2.086420e-04  2.184809e-04  2.287780e-04  2.395542e-04
## ASV1169      1.752768e-04  1.831946e-04  1.914506e-04  2.000575e-04
## ASV0189     -1.691106e-04 -1.771137e-04 -1.854921e-04 -1.942631e-04
## ASV2729      6.388601e-04  6.687254e-04  6.999565e-04  7.326128e-04
## ASV3469      1.450244e-04  1.517286e-04  1.587334e-04  1.660514e-04
## ASV0762     -3.434188e-04 -3.586852e-04 -3.745806e-04 -3.911264e-04
## ASV9001     -3.159915e-04 -3.295598e-04 -3.436496e-04 -3.582762e-04
## ASV14604    -2.563141e-04 -2.678801e-04 -2.799383e-04 -2.925068e-04
## ASV7439      7.697399e-05  8.076507e-05  8.474756e-05  8.893144e-05
## ASV8625     -2.562937e-04 -2.678579e-04 -2.799141e-04 -2.924805e-04
## ASV11553     5.118805e-05  5.375070e-05  5.644632e-05  5.928210e-05
## ASV14440     4.848999e-06  4.594840e-06  4.288188e-06  3.923538e-06
## ASV16106    -2.562720e-04 -2.678341e-04 -2.798881e-04 -2.924520e-04
## ASV16110    -2.562472e-04 -2.678070e-04 -2.798585e-04 -2.924198e-04
## ASV2229      4.507978e-04  4.707326e-04  4.914803e-04  5.130681e-04
## ASV3854     -2.480124e-04 -2.592068e-04 -2.708777e-04 -2.830430e-04
## ASV5512     -2.562137e-04 -2.677705e-04 -2.798186e-04 -2.923761e-04
## ASV5939      3.446415e-04  3.603387e-04  3.767172e-04  3.938033e-04
## ASV6676     -1.771295e-04 -1.851260e-04 -1.934631e-04 -2.021533e-04
## ASV8381     -2.561578e-04 -2.677094e-04 -2.797518e-04 -2.923033e-04
## ASV2735      3.268919e-04  3.418645e-04  3.574940e-04  3.738063e-04
## ASV9816     -2.561412e-04 -2.676913e-04 -2.797321e-04 -2.922817e-04
## ASV1382      1.145209e-04  1.194816e-04  1.246356e-04  1.299887e-04
## ASV1408     -2.572885e-04 -2.689522e-04 -2.811179e-04 -2.938049e-04
## ASV4902      1.654301e-04  1.734612e-04  1.818872e-04  1.907277e-04
## ASV5600      1.988299e-04  2.078103e-04  2.171744e-04  2.269365e-04
## ASV0815     -5.510000e-05 -5.744484e-05 -5.987653e-05 -6.239714e-05
## ASV11867    -2.572759e-04 -2.689386e-04 -2.811030e-04 -2.937886e-04
## ASV16064    -2.572509e-04 -2.689112e-04 -2.810732e-04 -2.937560e-04
## ASV2250      3.238901e-04  3.387664e-04  3.543005e-04  3.705192e-04
## ASV2417      7.662066e-05  8.035394e-05  8.427139e-05  8.838216e-05
## ASV2807      4.179782e-04  4.363894e-04  4.555457e-04  4.754719e-04
## ASV3224     -2.571938e-04 -2.688489e-04 -2.810052e-04 -2.936819e-04
## ASV4115     -2.571688e-04 -2.688216e-04 -2.809754e-04 -2.936493e-04
## ASV4876      4.190247e-05  4.374000e-05  4.564981e-05  4.763391e-05
## ASV5291      2.496247e-04  2.607308e-04  2.722948e-04  2.843324e-04
## ASV5834      1.214701e-04  1.269806e-04  1.327277e-04  1.387203e-04
## ASV6896      2.779485e-05  2.892422e-05  3.008977e-05  3.129170e-05
## ASV7292     -2.571531e-04 -2.688044e-04 -2.809566e-04 -2.936288e-04
## ASV7924      1.483990e-04  1.552676e-04  1.624445e-04  1.699425e-04
## ASV0710      3.395098e-04  3.547197e-04  3.705662e-04  3.870720e-04
## ASV1925      2.950353e-04  3.081224e-04  3.217460e-04  3.359242e-04
## ASV4247     -2.571261e-04 -2.687749e-04 -2.809244e-04 -2.935937e-04
## ASV4549     -2.571011e-04 -2.687476e-04 -2.808946e-04 -2.935611e-04
## ASV4076      2.152951e-04  2.250733e-04  2.352745e-04  2.459151e-04
## ASV7063      2.095970e-04  2.192295e-04  2.292868e-04  2.397860e-04
## ASV1487      2.205299e-04  2.301872e-04  2.402293e-04  2.506684e-04
## ASV1405      9.295904e-05  9.741280e-05  1.020800e-04  1.069708e-04
## ASV3851      2.296045e-04  2.403434e-04  2.515732e-04  2.633150e-04
## ASV0896      6.986957e-05  7.309171e-05  7.645767e-05  7.997346e-05
## ASV5581      3.344237e-04  3.501702e-04  3.666488e-04  3.838925e-04
## ASV7053     -1.095738e-04 -1.145770e-04 -1.197988e-04 -1.252479e-04
## ASV7171     -2.638177e-04 -2.760899e-04 -2.889195e-04 -3.023305e-04
## ASV4017     -3.608117e-04 -3.775009e-04 -3.949390e-04 -4.131573e-04
## ASV5846      1.993200e-05  2.019589e-05  2.041442e-05  2.058097e-05
## ASV0203      1.554701e-06  1.437209e-06  1.301901e-06  1.147507e-06
## ASV13271     3.991838e-05  4.149831e-05  4.312567e-05  4.480047e-05
## ASV9487      1.619577e-04  1.686094e-04  1.754875e-04  1.825957e-04
## ASV2056     -3.693177e-04 -3.863066e-04 -4.040485e-04 -4.225743e-04
## ASV16933    -3.622497e-04 -3.785699e-04 -3.955837e-04 -4.133168e-04
## ASV0360      1.565576e-04  1.633993e-04  1.705139e-04  1.779101e-04
## ASV1798     -2.355553e-04 -2.461568e-04 -2.572075e-04 -2.687239e-04
## ASV17286    -2.634664e-04 -2.757017e-04 -2.884904e-04 -3.018560e-04
## ASV8175     -2.634402e-04 -2.756730e-04 -2.884589e-04 -3.018216e-04
## ASV6679      2.774922e-04  2.899914e-04  3.030202e-04  3.165981e-04
## ASV6776      1.333042e-04  1.391521e-04  1.452333e-04  1.515551e-04
## ASV9062     -2.634163e-04 -2.756469e-04 -2.884303e-04 -3.017902e-04
## ASV9564     -2.391995e-05 -2.518839e-05 -2.652901e-05 -2.794630e-05
## ASV6431     -2.633881e-04 -2.756160e-04 -2.883964e-04 -3.017531e-04
## ASV9940      1.069007e-04  1.117170e-04  1.167368e-04  1.219675e-04
## ASV7001     -3.628312e-04 -3.791912e-04 -3.962463e-04 -4.140222e-04
## ASV3044      4.097146e-04  4.281910e-04  4.474540e-04  4.675330e-04
## ASV6684      1.531884e-04  1.605672e-04  1.683036e-04  1.764148e-04
## ASV12278     2.868581e-06  3.129478e-06  3.413213e-06  3.721661e-06
## ASV3543     -2.409430e-04 -2.513920e-04 -2.622501e-04 -2.735299e-04
## ASV6397      2.863355e-06  3.123759e-06  3.406955e-06  3.714816e-06
## ASV9939      2.862818e-06  3.123148e-06  3.406259e-06  3.714023e-06
## ASV9432      2.132859e-04  2.233481e-04  2.338793e-04  2.449008e-04
## ASV2630     -2.648011e-04 -2.771717e-04 -2.901080e-04 -3.036348e-04
## ASV2175      3.476797e-04  3.639508e-04  3.809696e-04  3.987691e-04
## ASV4107      2.861227e-04  2.993545e-04  3.131789e-04  3.276207e-04
## ASV9172     -3.727817e-05 -3.923551e-05 -4.130243e-05 -4.348557e-05
## ASV3141      3.415733e-04  3.576625e-04  3.745004e-04  3.921208e-04
## ASV9010     -2.642352e-04 -2.765443e-04 -2.894138e-04 -3.028680e-04
## ASV2550      2.607462e-04  2.726189e-04  2.850065e-04  2.979290e-04
## ASV5845     -2.642171e-04 -2.765245e-04 -2.893920e-04 -3.028441e-04
## ASV3998      2.641907e-04  2.764956e-04  2.893604e-04  3.028094e-04
## ASV1389     -2.810822e-04 -2.930975e-04 -3.055690e-04 -3.185096e-04
## ASV0615     -2.971710e-04 -3.107097e-04 -3.248375e-04 -3.395774e-04
## ASV9127     -3.640378e-04 -3.805560e-04 -3.977859e-04 -4.157546e-04
## ASV1190      5.155615e-04  5.384002e-04  5.621737e-04  5.869135e-04
## ASV1211      1.304412e-04  1.363679e-04  1.425521e-04  1.490042e-04
## ASV1766     -3.748300e-04 -3.919737e-04 -4.098681e-04 -4.285427e-04
## ASV2337      2.611719e-04  2.731840e-04  2.857280e-04  2.988252e-04
## ASV2463      5.622065e-05  5.880274e-05  6.149861e-05  6.431281e-05
## ASV2806      1.936262e-04  2.021869e-04  2.110993e-04  2.203758e-04
## ASV0439     -3.360379e-04 -3.514023e-04 -3.674385e-04 -3.841729e-04
## ASV0839      3.217146e-04  3.368603e-04  3.527081e-04  3.692891e-04
## ASV14975    -2.611263e-04 -2.731342e-04 -2.856734e-04 -2.987656e-04
## ASV17712    -2.611006e-04 -2.731060e-04 -2.856426e-04 -2.987319e-04
## ASV2010     -2.942129e-05 -3.068955e-05 -3.200555e-05 -3.337039e-05
## ASV2041      1.379843e-04  1.446617e-04  1.516644e-04  1.590080e-04
## ASV2124     -3.370607e-04 -3.526135e-04 -3.688596e-04 -3.858277e-04
## ASV2585      4.654969e-04  4.867109e-04  5.088465e-04  5.319394e-04
## ASV3314      3.696561e-04  3.868379e-04  4.047979e-04  4.235696e-04
## ASV5051     -3.316112e-05 -3.444279e-05 -3.575780e-05 -3.710526e-05
## ASV10784     1.306108e-04  1.365049e-04  1.426502e-04  1.490560e-04
## ASV3279     -2.610384e-04 -2.730380e-04 -2.855682e-04 -2.986505e-04
## ASV9498      1.746470e-05  1.807916e-05  1.870412e-05  1.933858e-05
## ASV1059     -2.793436e-04 -2.924066e-04 -3.060688e-04 -3.203565e-04
## ASV13008    -2.610120e-04 -2.730090e-04 -2.855365e-04 -2.986158e-04
## ASV15803    -2.609862e-04 -2.729809e-04 -2.855057e-04 -2.985821e-04
## ASV2559     -2.533531e-04 -2.650104e-04 -2.771844e-04 -2.898964e-04
## ASV2623     -2.609612e-04 -2.729535e-04 -2.854757e-04 -2.985493e-04
## ASV2802     -1.463480e-04 -1.529786e-04 -1.598941e-04 -1.671051e-04
## ASV3799      3.999870e-04  4.181285e-04  4.370512e-04  4.567850e-04
## ASV5274     -1.026133e-06 -1.236060e-06 -1.469872e-06 -1.729819e-06
## ASV5835      1.616190e-04  1.692358e-04  1.772081e-04  1.855523e-04
## ASV7251     -2.609553e-04 -2.729470e-04 -2.854686e-04 -2.985416e-04
## ASV7616     -2.609296e-04 -2.729189e-04 -2.854379e-04 -2.985079e-04
## ASV9576     -2.609039e-04 -2.728908e-04 -2.854071e-04 -2.984743e-04
## ASV2870      1.912820e-04  2.000918e-04  2.092924e-04  2.188999e-04
## ASV3668     -1.684661e-04 -1.763191e-04 -1.845291e-04 -1.931114e-04
## ASV1633      1.276709e-04  1.336915e-04  1.399925e-04  1.465865e-04
## ASV6060     -6.846333e-06 -7.666478e-06 -8.566220e-06 -9.552292e-06
## ASV6305      1.318848e-04  1.380793e-04  1.445601e-04  1.513400e-04
## ASV5164      8.437200e-05  8.797854e-05  9.171982e-05  9.559908e-05
## ASV7252     -2.616389e-04 -2.737018e-04 -2.863020e-04 -2.994618e-04
## ASV9343      2.268284e-04  2.376397e-04  2.489655e-04  2.608301e-04
## ASV6835     -4.348031e-05 -4.540776e-05 -4.741401e-05 -4.950170e-05
## ASV1264      3.178236e-04  3.322724e-04  3.473472e-04  3.630725e-04
## ASV0591      2.632884e-05  2.705967e-05  2.778072e-05  2.848802e-05
## ASV1351      3.680226e-04  3.850094e-04  4.027546e-04  4.212896e-04
## ASV14224    -2.615752e-04 -2.736321e-04 -2.862258e-04 -2.993784e-04
## ASV1432     -2.615493e-04 -2.736038e-04 -2.861948e-04 -2.993445e-04
## ASV1559     -2.195114e-04 -2.297201e-04 -2.403914e-04 -2.515452e-04
## ASV2182      4.052713e-04  4.236754e-04  4.428738e-04  4.628970e-04
## ASV2304     -2.149390e-05 -2.239948e-05 -2.333759e-05 -2.430888e-05
## ASV6838     -2.161411e-06 -2.236751e-06 -2.313330e-06 -2.391023e-06
## ASV1125     -3.955434e-05 -4.147696e-05 -4.349427e-05 -4.561099e-05
## ASV17948    -2.615400e-04 -2.735936e-04 -2.861837e-04 -2.993324e-04
## ASV2609      2.311412e-04  2.419212e-04  2.531927e-04  2.649769e-04
## ASV6128     -2.147418e-04 -2.246854e-04 -2.350698e-04 -2.459121e-04
## ASV1338      5.010806e-05  5.198192e-05  5.390041e-05  5.586204e-05
## ASV2136      9.389675e-05  9.792550e-05  1.021074e-04  1.064467e-04
## ASV0929     -2.379800e-04 -2.487361e-04 -2.599526e-04 -2.716469e-04
## ASV3479      1.637055e-04  1.709743e-04  1.785414e-04  1.864166e-04
## ASV0886      4.389246e-04  4.590072e-04  4.799697e-04  5.018469e-04
## ASV1652      2.018513e-04  2.111812e-04  2.209294e-04  2.311133e-04
## ASV1160      3.646699e-04  3.814825e-04  3.990439e-04  4.173851e-04
## ASV5260     -6.999917e-05 -7.352348e-05 -7.723106e-05 -8.113172e-05
## ASV2352      4.441266e-04  4.636893e-04  4.840445e-04  5.052184e-04
## ASV0986     -1.765592e-04 -1.844524e-04 -1.926757e-04 -2.012410e-04
## ASV2021      2.935855e-04  3.069056e-04  3.207996e-04  3.352896e-04
## ASV16599    -2.438086e-04 -2.557375e-04 -2.682556e-04 -2.813917e-04
## ASV3497      2.239874e-04  2.343909e-04  2.452658e-04  2.566326e-04
## ASV1305      1.517431e-04  1.590666e-04  1.667433e-04  1.747898e-04
## ASV0927     -3.385671e-04 -3.528805e-04 -3.677177e-04 -3.830909e-04
## ASV0647     -1.107256e-04 -1.152177e-04 -1.198554e-04 -1.246401e-04
## ASV1832     -1.457573e-04 -1.523209e-04 -1.591631e-04 -1.662944e-04
## ASV1277      1.738813e-04  1.817833e-04  1.900268e-04  1.986249e-04
## ASV22332    -2.622849e-04 -2.744079e-04 -2.870738e-04 -3.003052e-04
## ASV10080    -3.527180e-05 -3.753107e-05 -3.994556e-05 -4.252612e-05
## ASV14157     3.563352e-05  3.738705e-05  3.922888e-05  4.116358e-05
## ASV15829    -2.622578e-04 -2.743782e-04 -2.870411e-04 -3.002693e-04
## ASV3609     -2.622318e-04 -2.743497e-04 -2.870100e-04 -3.002353e-04
## ASV5737      5.735398e-05  5.973357e-05  6.219481e-05  6.473887e-05
## ASV1474      1.914941e-04  2.004011e-04  2.097106e-04  2.194398e-04
## ASV2028      2.575359e-04  2.684263e-04  2.797155e-04  2.914128e-04
## ASV0818      3.146761e-04  3.290697e-04  3.440933e-04  3.597718e-04
## ASV0505     -2.730743e-04 -2.857629e-04 -2.990239e-04 -3.128814e-04
## ASV1813      1.272432e-04  1.327407e-04  1.384501e-04  1.443770e-04
## ASV0512      2.844982e-04  2.979468e-04  3.120189e-04  3.267417e-04
## ASV5374     -2.006376e-04 -2.099073e-04 -2.195932e-04 -2.297130e-04
## ASV2927     -2.368336e-05 -2.421523e-05 -2.471944e-05 -2.519022e-05
## ASV3596      1.951564e-04  2.037207e-04  2.126273e-04  2.218870e-04
## ASV1137      1.161176e-04  1.211041e-04  1.262786e-04  1.316458e-04
## ASV4541      3.546806e-06  3.872144e-06  4.226340e-06  4.611820e-06
## ASV9872     -3.546137e-06 -3.871380e-06 -4.225469e-06 -4.610827e-06
## ASV0359     -9.127678e-05 -9.524725e-05 -9.937305e-05 -1.036587e-04
## ASV0720     -1.561960e-04 -1.630863e-04 -1.702547e-04 -1.777102e-04
## ASV10545    -3.560921e-06 -3.887454e-06 -4.242938e-06 -4.629802e-06
## ASV13384    -3.560249e-06 -3.886687e-06 -4.242064e-06 -4.628806e-06
## ASV1456      6.744695e-06  7.023505e-06  7.311973e-06  7.610274e-06
## ASV1751     -3.559957e-06 -3.886333e-06 -4.241637e-06 -4.628294e-06
## ASV18419    -3.559286e-06 -3.885567e-06 -4.240763e-06 -4.627297e-06
## ASV2970      3.558614e-06  3.884801e-06  4.239889e-06  4.626302e-06
## ASV4215      2.043332e-04  2.136665e-04  2.234068e-04  2.335701e-04
## ASV4742      3.307208e-05  3.432721e-05  3.561445e-05  3.693311e-05
## ASV5017      6.396319e-05  6.675369e-05  6.965425e-05  7.266819e-05
## ASV5139     -3.554113e-06 -3.879774e-06 -4.234275e-06 -4.620030e-06
## ASV9133     -3.553443e-06 -3.879010e-06 -4.233403e-06 -4.619036e-06
## ASV9447     -3.552773e-06 -3.878245e-06 -4.232531e-06 -4.618042e-06
## ASV0842     -1.918798e-04 -2.000232e-04 -2.084691e-04 -2.172250e-04
## ASV12293     1.338814e-04  1.394005e-04  1.451089e-04  1.510098e-04
## ASV1965      2.463275e-04  2.577600e-04  2.697091e-04  2.821970e-04
## ASV2005      2.655812e-04  2.768806e-04  2.886005e-04  3.007514e-04
## ASV5335      1.982291e-04  2.068149e-04  2.157335e-04  2.249945e-04
## ASV6438     -3.589196e-06 -3.917862e-06 -4.275603e-06 -4.664853e-06
## ASV7798     -3.588520e-06 -3.917090e-06 -4.274724e-06 -4.663850e-06
## ASV2691     -2.770962e-04 -2.898929e-04 -3.032606e-04 -3.172230e-04
## ASV9958      2.255772e-04  2.357098e-04  2.462695e-04  2.572717e-04
## ASV1512      8.275790e-05  8.671431e-05  9.086066e-05  9.520614e-05
## ASV1226      3.711651e-04  3.880389e-04  4.056437e-04  4.240079e-04
## ASV2130     -6.546687e-04 -6.843876e-04 -7.153885e-04 -7.477207e-04
## ASV0874     -2.035616e-04 -2.127550e-04 -2.223435e-04 -2.323424e-04
## ASV5436     -2.919338e-04 -3.053468e-04 -3.193520e-04 -3.339734e-04
## ASV0383     -3.187006e-04 -3.324406e-04 -3.467085e-04 -3.615189e-04
## ASV1882      3.117745e-04  3.252482e-04  3.392455e-04  3.537818e-04
## ASV2471     -1.774289e-04 -1.854688e-04 -1.938544e-04 -2.025987e-04
## ASV4049     -2.518250e-04 -2.631678e-04 -2.749916e-04 -2.873140e-04
## ASV3014     -1.403650e-04 -1.465013e-04 -1.528812e-04 -1.595120e-04
## ASV0316     -5.052417e-04 -5.281970e-04 -5.521442e-04 -5.771216e-04
## ASV1621     -3.496152e-04 -3.652385e-04 -3.815140e-04 -3.984649e-04
## ASV13266    -2.571576e-04 -2.688051e-04 -2.809527e-04 -2.936192e-04
## ASV1635     -2.549826e-04 -2.665276e-04 -2.785678e-04 -2.911220e-04
## ASV2042      1.873486e-04  1.958471e-04  2.047117e-04  2.139566e-04
## ASV2317     -3.054451e-04 -3.192205e-04 -3.335819e-04 -3.485510e-04
## ASV3697      2.303077e-04  2.405367e-04  2.511871e-04  2.622732e-04
## ASV6404      4.233936e-04  4.420895e-04  4.615474e-04  4.817931e-04
## ASV15616     1.837037e-05  1.943191e-05  2.056016e-05  2.175958e-05
## ASV10783    -2.571042e-04 -2.687468e-04 -2.808890e-04 -2.935496e-04
## ASV6912     -1.926889e-04 -2.013467e-04 -2.103698e-04 -2.197712e-04
## ASV1561      5.198649e-04  5.429485e-04  5.669828e-04  5.920005e-04
## ASV4404      3.552657e-04  3.713099e-04  3.880387e-04  4.054779e-04
## ASV1110      2.605030e-04  2.721496e-04  2.842823e-04  2.969181e-04
## ASV2844     -8.913319e-05 -9.340197e-05 -9.787528e-05 -1.025629e-04
## ASV5224      2.603616e-04  2.721089e-04  2.843557e-04  2.971203e-04
## ASV6300     -2.618728e-04 -2.739561e-04 -2.865786e-04 -2.997623e-04
## ASV8078     -2.618469e-04 -2.739278e-04 -2.865475e-04 -2.997284e-04
## ASV9722      1.861176e-07 -1.037935e-07 -4.337755e-07 -8.079016e-07
## ASV6911     -2.618206e-04 -2.738990e-04 -2.865160e-04 -2.996938e-04
## ASV5474     -5.400646e-05 -5.661838e-05 -5.935766e-05 -6.223052e-05
## ASV2761     -6.118816e-04 -6.395049e-04 -6.683058e-04 -6.983282e-04
## ASV5943     -1.717347e-04 -1.799956e-04 -1.886565e-04 -1.977370e-04
## ASV0600     -4.280498e-05 -4.423689e-05 -4.568508e-05 -4.714625e-05
## ASV0608     -5.485460e-04 -5.731740e-04 -5.988411e-04 -6.255853e-04
## ASV1586      1.316083e-04  1.373518e-04  1.433237e-04  1.495312e-04
## ASV0206     -6.074107e-04 -6.341008e-04 -6.618632e-04 -6.907322e-04
## ASV4042     -2.795036e-04 -2.921877e-04 -3.054185e-04 -3.192167e-04
## ASV5304     -8.596866e-06 -9.066816e-06 -9.563414e-06 -1.008813e-05
## ASV0949     -9.938789e-05 -1.045923e-04 -1.100832e-04 -1.158773e-04
## ASV1856      3.220613e-04  3.367094e-04  3.519912e-04  3.679311e-04
## ASV2584      3.747184e-05  3.900090e-05  4.057855e-05  4.220486e-05
## ASV2287     -1.768440e-05 -1.899696e-05 -2.040882e-05 -2.192711e-05
## ASV2364     -4.564236e-04 -4.770087e-04 -4.984703e-04 -5.208410e-04
## ASV11481    -3.656749e-04 -3.827529e-04 -4.006115e-04 -4.192848e-04
## ASV2906     -1.273532e-04 -1.333378e-04 -1.395989e-04 -1.461487e-04
## ASV0161     -1.512813e-04 -1.580891e-04 -1.651848e-04 -1.725787e-04
## ASV0062     -9.946046e-04 -1.039469e-03 -1.086242e-03 -1.134994e-03
## ASV3811     -2.322958e-04 -2.419670e-04 -2.519829e-04 -2.623512e-04
## ASV0225      3.784315e-05  3.911729e-05  4.040892e-05  4.171574e-05
## ASV4672     -3.181401e-04 -3.322781e-04 -3.469994e-04 -3.623241e-04
## ASV1607     -2.449741e-05 -2.566298e-05 -2.688143e-05 -2.815475e-05
## ASV3060      6.369720e-05  6.677246e-05  6.999758e-05  7.337994e-05
## ASV2275     -4.554810e-05 -4.761283e-05 -4.976618e-05 -5.201149e-05
## ASV5375      1.792797e-04  1.877088e-04  1.965286e-04  2.057565e-04
## ASV0352     -5.345579e-04 -5.592763e-04 -5.851024e-04 -6.120825e-04
## ASV1107      1.548007e-04  1.621697e-04  1.698851e-04  1.779626e-04
## ASV4887      1.373422e-04  1.431901e-04  1.492552e-04  1.555428e-04
## ASV2397     -6.868922e-05 -7.144117e-05 -7.427868e-05 -7.720210e-05
## ASV7541     -1.668871e-04 -1.743598e-04 -1.821450e-04 -1.902536e-04
## ASV7387     -3.659175e-04 -3.825733e-04 -3.999508e-04 -4.180776e-04
## ASV1355      3.360763e-04  3.515325e-04  3.676747e-04  3.845312e-04
## ASV1764     -1.746383e-04 -1.824709e-04 -1.906333e-04 -1.991374e-04
## ASV1960     -3.183679e-04 -3.317577e-04 -3.456352e-04 -3.600121e-04
## ASV0484     -6.183553e-05 -6.464445e-05 -6.757505e-05 -7.063211e-05
## ASV2487      9.829349e-05  1.022472e-04  1.063265e-04  1.105323e-04
## ASV0422      3.101654e-04  3.234352e-04  3.372101e-04  3.515042e-04
## ASV0081     -1.970602e-04 -2.063799e-04 -2.161366e-04 -2.263503e-04
## ASV1341     -1.675794e-04 -1.747864e-04 -1.822686e-04 -1.900333e-04
## ASV1001     -3.970208e-04 -4.142262e-04 -4.321009e-04 -4.506643e-04
## ASV0317     -9.779862e-05 -1.025415e-04 -1.075133e-04 -1.127247e-04
## ASV2728     -2.776103e-04 -2.902060e-04 -3.033450e-04 -3.170482e-04
## ASV0884     -3.590023e-04 -3.761362e-04 -3.940851e-04 -4.128871e-04
## ASV0464      7.875567e-05  8.305798e-05  8.761234e-05  9.243447e-05
## ASV2963      2.422055e-04  2.529377e-04  2.641109e-04  2.757404e-04
## ASV4608      1.097850e-04  1.147560e-04  1.199398e-04  1.253444e-04
## ASV3534      2.697595e-04  2.811820e-04  2.930244e-04  3.052964e-04
## ASV0291     -2.340061e-04 -2.444085e-04 -2.552392e-04 -2.665126e-04
## ASV0635     -3.400278e-04 -3.558487e-04 -3.723879e-04 -3.896764e-04
## ASV0867      2.745714e-04  2.875876e-04  3.012166e-04  3.154867e-04
## ASV1206     -3.106879e-05 -3.231115e-05 -3.359144e-05 -3.490969e-05
## ASV1230     -2.368500e-06 -2.590619e-06 -2.833097e-06 -3.097731e-06
## ASV1265      7.254124e-05  7.582944e-05  7.925935e-05  8.283647e-05
## ASV1291     -2.249657e-04 -2.354511e-04 -2.464139e-04 -2.578747e-04
## ASV1524      4.596095e-04  4.797414e-04  5.006766e-04  5.224404e-04
## ASV2153     -3.546348e-04 -3.701804e-04 -3.863491e-04 -4.031610e-04
## ASV2714      2.332129e-06  2.551002e-06  2.789958e-06  3.050772e-06
## ASV4246     -2.331680e-06 -2.550488e-06 -2.789370e-06 -3.050100e-06
## ASV0945      2.373984e-04  2.481561e-04  2.593753e-04  2.710736e-04
## ASV2380      5.487158e-04  5.728143e-04  5.978821e-04  6.239506e-04
## ASV0214     -7.999871e-05 -8.284905e-05 -8.575445e-05 -8.871140e-05
## ASV10461    -2.371347e-06 -2.593793e-06 -2.836635e-06 -3.101675e-06
## ASV4177      1.593676e-04  1.660428e-04  1.729562e-04  1.801127e-04
## ASV0237     -4.006878e-04 -4.192357e-04 -4.386160e-04 -4.588635e-04
## ASV11323    -4.519114e-04 -4.726467e-04 -4.942975e-04 -5.169010e-04
## ASV2232     -7.733605e-05 -8.068562e-05 -8.416508e-05 -8.777813e-05
## ASV0115     -1.454087e-04 -1.520069e-04 -1.588885e-04 -1.660640e-04
## ASV1171      6.593332e-05  6.846263e-05  7.106008e-05  7.372476e-05
## ASV1942      3.131037e-04  3.274846e-04  3.425022e-04  3.581823e-04
## ASV1889      3.100521e-05  3.232304e-05  3.368915e-05  3.510456e-05
## ASV0920      7.009310e-05  7.347801e-05  7.702738e-05  8.074916e-05
## ASV1805     -4.004745e-04 -4.186041e-04 -4.375113e-04 -4.572258e-04
## ASV1712      2.391479e-04  2.497528e-04  2.607910e-04  2.722770e-04
## ASV1458      3.506707e-04  3.660385e-04  3.820232e-04  3.986450e-04
## ASV1985      3.740521e-04  3.908499e-04  4.083573e-04  4.266005e-04
## ASV2960     -2.361339e-04 -2.459239e-04 -2.560591e-04 -2.665466e-04
## ASV5207     -6.998043e-05 -7.234285e-05 -7.473976e-05 -7.716733e-05
## ASV8548     -2.361086e-04 -2.458967e-04 -2.560296e-04 -2.665148e-04
## ASV0449     -1.447112e-04 -1.516133e-04 -1.588386e-04 -1.664012e-04
## ASV0609     -3.230630e-04 -3.374777e-04 -3.524901e-04 -3.681211e-04
## ASV1038      1.226701e-04  1.277226e-04  1.329471e-04  1.383460e-04
## ASV1145     -7.358650e-05 -7.650696e-05 -7.951708e-05 -8.261730e-05
## ASV15767    -2.361039e-04 -2.458917e-04 -2.560244e-04 -2.665093e-04
## ASV1630      3.350443e-04  3.495295e-04  3.645798e-04  3.802122e-04
## ASV1911      4.212079e-04  4.404006e-04  4.604279e-04  4.813225e-04
## ASV1950      3.015183e-04  3.143848e-04  3.277388e-04  3.415940e-04
## ASV2583      2.360305e-04  2.458120e-04  2.559380e-04  2.664156e-04
## ASV2853     -3.489765e-04 -3.641773e-04 -3.799802e-04 -3.964042e-04
## ASV2948      2.359868e-04  2.457645e-04  2.558864e-04  2.663596e-04
## ASV3116     -3.795283e-04 -3.958011e-04 -4.126953e-04 -4.302285e-04
## ASV3160     -2.023801e-04 -2.106035e-04 -2.191012e-04 -2.278776e-04
## ASV3354      2.534184e-04  2.650097e-04  2.771063e-04  2.897277e-04
## ASV3368      2.359269e-04  2.456997e-04  2.558162e-04  2.662836e-04
## ASV3464     -2.359061e-04 -2.456771e-04 -2.557917e-04 -2.662572e-04
## ASV3577      2.358853e-04  2.456546e-04  2.557673e-04  2.662307e-04
## ASV3746      3.099357e-04  3.231280e-04  3.368141e-04  3.510068e-04
## ASV3942      1.053099e-04  1.106460e-04  1.162609e-04  1.221695e-04
## ASV4000      2.358508e-04  2.456172e-04  2.557268e-04  2.661870e-04
## ASV4207      4.296336e-04  4.496558e-04  4.705885e-04  4.924711e-04
## ASV4261      2.358328e-04  2.455977e-04  2.557058e-04  2.661643e-04
## ASV4466      9.014751e-05  9.503282e-05  1.001948e-04  1.056491e-04
## ASV4487     -2.358192e-04 -2.455832e-04 -2.556903e-04 -2.661476e-04
## ASV4572     -1.791651e-04 -1.867791e-04 -1.946796e-04 -2.028743e-04
## ASV4718      2.357846e-04  2.455457e-04  2.556496e-04  2.661036e-04
## ASV4757     -2.357638e-04 -2.455231e-04 -2.556252e-04 -2.660771e-04
## ASV4929     -2.357430e-04 -2.455006e-04 -2.556008e-04 -2.660507e-04
## ASV5611     -2.357222e-04 -2.454781e-04 -2.555764e-04 -2.660243e-04
## ASV5614     -2.357014e-04 -2.454555e-04 -2.555520e-04 -2.659979e-04
## ASV5898      2.061029e-04  2.151701e-04  2.246022e-04  2.344108e-04
## ASV7627     -4.932983e-05 -5.078929e-05 -5.224735e-05 -5.369906e-05
## ASV3105     -1.288482e-04 -1.339631e-04 -1.392391e-04 -1.446779e-04
## ASV4762     -3.490908e-04 -3.643100e-04 -3.801334e-04 -3.965799e-04
## ASV5622      2.356487e-04  2.453984e-04  2.554902e-04  2.659311e-04
## ASV7129      3.100629e-04  3.238734e-04  3.382568e-04  3.532333e-04
## ASV12138    -2.356201e-04 -2.453674e-04 -2.554566e-04 -2.658947e-04
## ASV1687     -3.554118e-04 -3.712487e-04 -3.877475e-04 -4.049325e-04
## ASV2187      1.745499e-04  1.816802e-04  1.890527e-04  1.966719e-04
## ASV2204      3.594854e-04  3.753816e-04  3.919250e-04  4.091372e-04
## ASV2914      2.763962e-04  2.880397e-04  3.001106e-04  3.126196e-04
## ASV3297     -2.355441e-04 -2.452849e-04 -2.553671e-04 -2.657976e-04
## ASV3310     -3.038020e-04 -3.167458e-04 -3.301778e-04 -3.441112e-04
## ASV3677      2.083581e-05  2.259207e-05  2.449109e-05  2.654346e-05
## ASV4508      2.354996e-04  2.452368e-04  2.553150e-04  2.657414e-04
## ASV6236     -1.128422e-04 -1.170101e-04 -1.212789e-04 -1.256463e-04
## ASV6285      2.354706e-04  2.452055e-04  2.552812e-04  2.657049e-04
## ASV7576     -2.354499e-04 -2.451830e-04 -2.552568e-04 -2.656785e-04
## ASV7917     -2.354291e-04 -2.451605e-04 -2.552325e-04 -2.656522e-04
## ASV9353     -2.354084e-04 -2.451380e-04 -2.552082e-04 -2.656259e-04
## ASV1656      3.937098e-04  4.109986e-04  4.289828e-04  4.476849e-04
## ASV0280     -3.776486e-04 -3.952623e-04 -4.136796e-04 -4.329355e-04
## ASV4747      7.745846e-06  8.479633e-06  9.281249e-06  1.015674e-05
## ASV2108     -4.625809e-04 -4.839825e-04 -5.063456e-04 -5.297107e-04
## ASV0885      1.548618e-04  1.619516e-04  1.693530e-04  1.770786e-04
## ASV2538     -1.249321e-04 -1.303965e-04 -1.360777e-04 -1.419823e-04
## ASV0968      2.846013e-04  2.974175e-04  3.107767e-04  3.246991e-04
## ASV1229     -2.556522e-04 -2.671528e-04 -2.791391e-04 -2.916286e-04
## ASV13306    -2.556276e-04 -2.671259e-04 -2.791097e-04 -2.915966e-04
## ASV13952     1.549848e-04  1.615700e-04  1.683998e-04  1.754801e-04
## ASV14631     1.440302e-04  1.511327e-04  1.585951e-04  1.664362e-04
## ASV2119      2.997768e-04  3.125039e-04  3.257023e-04  3.393836e-04
## ASV2450      2.670165e-04  2.792469e-04  2.920153e-04  3.053435e-04
## ASV2656     -2.556180e-04 -2.671155e-04 -2.790985e-04 -2.915844e-04
## ASV2942     -1.838927e-05 -1.916764e-05 -1.997406e-05 -2.080906e-05
## ASV3302      2.275428e-04  2.376332e-04  2.481364e-04  2.590661e-04
## ASV6515      8.665002e-05  9.014296e-05  9.374820e-05  9.746687e-05
## ASV6674     -2.555978e-04 -2.670934e-04 -2.790743e-04 -2.915580e-04
## ASV7296     -9.516804e-05 -9.959390e-05 -1.042195e-04 -1.090533e-04
## ASV7903      1.394119e-04  1.453886e-04  1.515929e-04  1.580310e-04
## ASV7943     -2.555719e-04 -2.670651e-04 -2.790433e-04 -2.915241e-04
## ASV8864      1.852755e-04  1.927199e-04  2.004010e-04  2.083208e-04
## ASV9389      2.202633e-05  2.240700e-05  2.275053e-05  2.305107e-05
## ASV9869     -2.555544e-04 -2.670458e-04 -2.790221e-04 -2.915008e-04
## ASV1051      2.555297e-04  2.670189e-04  2.789928e-04  2.914688e-04
## ASV13035    -1.095948e-05 -1.135728e-05 -1.176302e-05 -1.217618e-05
## ASV15744     8.341298e-06  9.167162e-06  1.007072e-05  1.105894e-05
## ASV2526      2.615384e-05  2.706633e-05  2.799476e-05  2.893786e-05
## ASV1156      1.334652e-04  1.393812e-04  1.455398e-04  1.519493e-04
## ASV13562    -2.555158e-04 -2.670038e-04 -2.789763e-04 -2.914508e-04
## ASV1438      2.246167e-04  2.350547e-04  2.459665e-04  2.573730e-04
## ASV2268     -2.555033e-04 -2.669901e-04 -2.789614e-04 -2.914347e-04
## ASV2797      1.238479e-04  1.297579e-04  1.359497e-04  1.424370e-04
## ASV3744      2.857347e-04  2.988669e-04  3.125790e-04  3.268942e-04
## ASV8076     -2.753872e-04 -2.877921e-04 -3.007224e-04 -3.141972e-04
## ASV7055      1.197548e-04  1.256307e-04  1.318010e-04  1.382809e-04
## ASV7493     -2.336449e-04 -2.442474e-04 -2.553067e-04 -2.668402e-04
## ASV1201      5.675881e-04  5.930440e-04  6.195699e-04  6.472046e-04
## ASV5736     -4.926234e-04 -5.151891e-04 -5.387459e-04 -5.633334e-04
## ASV0558      2.390475e-04  2.502030e-04  2.618662e-04  2.740590e-04
## ASV14399    -3.402090e-04 -3.554387e-04 -3.713064e-04 -3.878352e-04
## ASV2992     -1.917965e-05 -2.001906e-05 -2.089177e-05 -2.179879e-05
## ASV4303     -2.500659e-04 -2.613039e-04 -2.730155e-04 -2.852178e-04
## ASV0565     -2.852197e-04 -2.981799e-04 -3.117018e-04 -3.258076e-04
## ASV0977     -4.213538e-04 -4.394134e-04 -4.581624e-04 -4.776205e-04
## ASV0140      2.137544e-04  2.233584e-04  2.333675e-04  2.437964e-04
## ASV14421    -2.566836e-04 -2.682869e-04 -2.803861e-04 -2.929999e-04
## ASV16909    -5.759425e-05 -6.034334e-05 -6.322313e-05 -6.623971e-05
## ASV3762     -2.566540e-04 -2.682545e-04 -2.803507e-04 -2.929612e-04
## ASV7141     -2.566291e-04 -2.682273e-04 -2.803210e-04 -2.929288e-04
## ASV3291      4.091024e-04  4.279832e-04  4.477069e-04  4.683085e-04
## ASV10440    -2.566002e-04 -2.681958e-04 -2.802866e-04 -2.928912e-04
## ASV10802     7.809140e-05  8.155480e-05  8.516009e-05  8.891206e-05
## ASV1698      4.335315e-05  4.547198e-05  4.769638e-05  5.003174e-05
## ASV2121      2.565819e-04  2.681758e-04  2.802647e-04  2.928673e-04
## ASV3549     -3.625273e-04 -3.789684e-04 -3.961165e-04 -4.139987e-04
## ASV6379      3.018379e-04  3.150891e-04  3.288720e-04  3.432039e-04
## ASV6824     -2.565271e-04 -2.681159e-04 -2.801994e-04 -2.927960e-04
## ASV8254      2.709980e-05  2.845700e-05  2.988431e-05  3.138546e-05
## ASV9951      1.136728e-04  1.190428e-04  1.246639e-04  1.305473e-04
## ASV1515     -1.065816e-04 -1.111416e-04 -1.158723e-04 -1.207778e-04
## ASV4327      7.831316e-05  8.186580e-05  8.557177e-05  8.943700e-05
## ASV0341     -1.198833e-04 -1.255508e-04 -1.314831e-04 -1.376922e-04
## ASV5562     -2.105690e-04 -2.204219e-04 -2.307274e-04 -2.415057e-04
## ASV1412      5.752128e-04  6.014109e-04  6.287483e-04  6.572697e-04
## ASV0154     -4.636238e-04 -4.849873e-04 -5.073020e-04 -5.306075e-04
## ASV3163     -2.137022e-04 -2.232764e-04 -2.332533e-04 -2.436476e-04
## ASV1782     -3.411394e-04 -3.566045e-04 -3.727332e-04 -3.895505e-04
## ASV3993     -3.623983e-05 -3.765246e-05 -3.910494e-05 -4.059692e-05
## ASV3164      1.632302e-04  1.703497e-04  1.777491e-04  1.854369e-04
## ASV1024      2.148979e-05  2.266383e-05  2.390741e-05  2.522501e-05
## ASV0771     -4.646833e-04 -4.852054e-04 -5.065606e-04 -5.287764e-04
## ASV2223     -2.079636e-04 -2.178448e-04 -2.281900e-04 -2.390200e-04
## ASV1638      7.703513e-04  8.048833e-04  8.408656e-04  8.783503e-04
## ASV0232     -2.262666e-04 -2.364565e-04 -2.470788e-04 -2.581494e-04
## ASV6771     -2.519274e-04 -2.636946e-04 -2.759976e-04 -2.888595e-04
## ASV4243     -9.760081e-05 -1.017040e-04 -1.059590e-04 -1.103701e-04
## ASV0162     -4.624674e-04 -4.834291e-04 -5.052894e-04 -5.280818e-04
## ASV0049      3.203608e-05  3.351563e-05  3.506164e-05  3.667696e-05
## ASV4697     -2.579658e-04 -2.696864e-04 -2.819132e-04 -2.946658e-04
## ASV12326     8.138911e-05  8.482693e-05  8.838983e-05  9.208058e-05
## ASV12586    -2.579445e-04 -2.696631e-04 -2.818877e-04 -2.946379e-04
## ASV1879      2.042875e-04  2.135883e-04  2.232920e-04  2.334140e-04
## ASV2864      5.640127e-04  5.899447e-04  6.170256e-04  6.453022e-04
## ASV3111     -1.499040e-04 -1.566840e-04 -1.637541e-04 -1.711253e-04
## ASV5633     -1.436790e-04 -1.501300e-04 -1.568527e-04 -1.638570e-04
## ASV5864      8.548294e-05  8.878505e-05  9.217834e-05  9.566190e-05
## ASV6364      1.249017e-04  1.308392e-04  1.370579e-04  1.435708e-04
## ASV1598      1.594048e-04  1.666930e-04  1.743020e-04  1.822452e-04
## ASV2649     -9.597704e-05 -1.006847e-04 -1.056272e-04 -1.108164e-04
## ASV4664      2.114672e-04  2.208126e-04  2.305393e-04  2.406602e-04
## ASV2654      3.573816e-04  3.735256e-04  3.903580e-04  4.079045e-04
## ASV6636     -2.621449e-05 -2.780803e-05 -2.950489e-05 -3.131183e-05
## ASV3334      2.680302e-04  2.806620e-04  2.938807e-04  3.077128e-04
## ASV0046     -4.772492e-04 -4.996021e-04 -5.229823e-04 -5.474349e-04
## ASV0661      4.792273e-04  5.005395e-04  5.227323e-04  5.458362e-04
## ASV0774      2.159240e-04  2.257612e-04  2.360252e-04  2.467322e-04
## ASV3815      2.572973e-04  2.688071e-04  2.807973e-04  2.932848e-04
## ASV0575      2.581286e-04  2.693461e-04  2.810039e-04  2.931154e-04
## ASV1953     -3.590429e-04 -3.753336e-04 -3.923249e-04 -4.100436e-04
## ASV0610      1.076134e-04  1.123188e-04  1.172115e-04  1.222977e-04
## ASV0245     -1.313263e-04 -1.373367e-04 -1.436108e-04 -1.501592e-04
## ASV3805     -1.864152e-04 -1.938879e-04 -2.016006e-04 -2.095562e-04
## ASV1182      5.380263e-04  5.630517e-04  5.892126e-04  6.165580e-04
## ASV1941      1.518214e-06  1.662283e-06  1.819782e-06  1.991921e-06
## ASV0080     -6.300470e-04 -6.585085e-04 -6.881841e-04 -7.191190e-04
## ASV1033      1.883631e-04  1.969271e-04  2.058616e-04  2.151810e-04
## ASV5330     -2.259189e-04 -2.360418e-04 -2.465887e-04 -2.575747e-04
## ASV9702     -3.433514e-04 -3.580314e-04 -3.732687e-04 -3.890785e-04
## ASV0358      8.580469e-06  8.759025e-06  8.925899e-06  9.078875e-06
## ASV2225      1.786878e-04  1.867091e-04  1.950678e-04  2.037759e-04
## ASV2606      7.529809e-06  7.673353e-06  7.804376e-06  7.920623e-06
## ASV3510     -2.787981e-04 -2.914576e-04 -3.046632e-04 -3.184360e-04
## ASV3069      9.416792e-05  9.804833e-05  1.020629e-04  1.062142e-04
## ASV3849      1.722945e-04  1.798512e-04  1.877095e-04  1.958787e-04
## ASV1810     -4.328826e-04 -4.516112e-04 -4.710704e-04 -4.912821e-04
## ASV2046      6.407801e-04  6.701158e-04  7.007386e-04  7.326999e-04
## ASV2451     -7.897923e-05 -8.300086e-05 -8.723420e-05 -9.169061e-05
## ASV4047      3.339036e-04  3.489459e-04  3.646272e-04  3.809712e-04
## ASV7402     -2.650929e-04 -2.774534e-04 -2.903750e-04 -3.038816e-04
## ASV8250      3.250904e-04  3.401493e-04  3.558856e-04  3.723275e-04
## ASV3468      2.780382e-04  2.905526e-04  3.035971e-04  3.171912e-04
## ASV3521      5.728469e-04  5.989750e-04  6.262419e-04  6.546925e-04
## ASV6363     -1.955562e-04 -2.047719e-04 -2.144145e-04 -2.245026e-04
## ASV6444      1.308218e-04  1.369994e-04  1.434672e-04  1.502388e-04
## ASV8231      1.499633e-04  1.566239e-04  1.635592e-04  1.707787e-04
## ASV0196     -8.571210e-04 -8.957909e-04 -9.361071e-04 -9.781310e-04
## ASV12801    -2.651056e-04 -2.774671e-04 -2.903899e-04 -3.038977e-04
## ASV12906    -2.650791e-04 -2.774381e-04 -2.903581e-04 -3.038629e-04
## ASV13040    -2.650526e-04 -2.774091e-04 -2.903263e-04 -3.038281e-04
## ASV1313     -2.798757e-05 -2.961885e-05 -3.135275e-05 -3.319604e-05
## ASV14008     7.544638e-05  7.916768e-05  8.307932e-05  8.719170e-05
## ASV1546      1.005179e-04  1.046697e-04  1.089640e-04  1.134032e-04
## ASV1637      4.955470e-04  5.179877e-04  5.413901e-04  5.657905e-04
## ASV17076     2.142471e-04  2.236576e-04  2.334453e-04  2.436221e-04
## ASV2061      7.356503e-04  7.683951e-04  8.024943e-04  8.379948e-04
## ASV2177      3.064369e-04  3.208746e-04  3.359838e-04  3.517945e-04
## ASV2943      4.485539e-04  4.687187e-04  4.897340e-04  5.116307e-04
## ASV3020      3.949254e-04  4.125346e-04  4.308742e-04  4.499694e-04
## ASV30254     1.815349e-05  1.857946e-05  1.898936e-05  1.937972e-05
## ASV3219      5.543085e-04  5.790811e-04  6.048873e-04  6.317639e-04
## ASV3352      4.858263e-04  5.080546e-04  5.312582e-04  5.554760e-04
## ASV3355      2.090376e-04  2.187840e-04  2.289723e-04  2.396211e-04
## ASV3377      3.773152e-04  3.945515e-04  4.125421e-04  4.313171e-04
## ASV3449      2.181784e-04  2.276720e-04  2.375383e-04  2.477885e-04
## ASV3893      2.650237e-04  2.773772e-04  2.902912e-04  3.037893e-04
## ASV4326      1.535336e-04  1.600818e-04  1.668750e-04  1.739194e-04
## ASV5016     -2.650049e-04 -2.773566e-04 -2.902685e-04 -3.037645e-04
## ASV5152      2.030544e-04  2.115184e-04  2.202811e-04  2.293482e-04
## ASV5666     -1.091679e-05 -1.165153e-05 -1.243822e-05 -1.328046e-05
## ASV5802     -2.714354e-04 -2.840633e-04 -2.972620e-04 -3.110555e-04
## ASV6070      1.866327e-04  1.947462e-04  2.031774e-04  2.119359e-04
## ASV6488      1.627017e-04  1.699807e-04  1.775640e-04  1.854626e-04
## ASV6562     -2.649613e-04 -2.773087e-04 -2.902159e-04 -3.037068e-04
## ASV6930      1.915797e-04  1.999212e-04  2.085906e-04  2.175977e-04
## ASV7243      3.478394e-04  3.632886e-04  3.793733e-04  3.961153e-04
## ASV7506      2.207289e-04  2.304189e-04  2.404971e-04  2.509759e-04
## ASV7553     -2.649416e-04 -2.772871e-04 -2.901922e-04 -3.036808e-04
## ASV8064      1.499991e-04  1.565921e-04  1.634494e-04  1.705792e-04
## ASV8434     -1.477756e-04 -1.548202e-04 -1.621977e-04 -1.699232e-04
## ASV8858     -2.649092e-04 -2.772515e-04 -2.901533e-04 -3.036380e-04
## ASV2600      1.524453e-04  1.595445e-04  1.669647e-04  1.747193e-04
## ASV3398      5.721235e-04  5.983099e-04  6.256461e-04  6.541780e-04
## ASV4584     -2.648705e-04 -2.772092e-04 -2.901068e-04 -3.035872e-04
## ASV4864      2.889587e-04  3.020246e-04  3.156495e-04  3.298546e-04
## ASV0082     -1.128830e-03 -1.180001e-03 -1.233373e-03 -1.289031e-03
## ASV9626      2.333580e-04  2.439971e-04  2.550985e-04  2.666803e-04
## ASV1617      1.003096e-04  1.043544e-04  1.085290e-04  1.128347e-04
## ASV2765     -6.123692e-05 -6.431190e-05 -6.754504e-05 -7.094452e-05
## ASV2167     -3.504904e-04 -3.663481e-04 -3.828847e-04 -4.001259e-04
## ASV1628      2.196023e-04  2.287954e-04  2.383184e-04  2.481782e-04
## ASV3260     -5.490755e-05 -5.719211e-05 -5.955610e-05 -6.200086e-05
## ASV3645      3.352510e-05  3.533254e-05  3.724050e-05  3.925443e-05
## ASV6057     -3.344809e-04 -3.496226e-04 -3.654135e-04 -3.818785e-04
## ASV0662     -4.408243e-05 -4.590304e-05 -4.778622e-05 -4.973299e-05
## ASV4267     -4.320762e-05 -4.529659e-05 -4.748605e-05 -4.978063e-05
## ASV1070      3.590135e-04  3.757662e-04  3.932841e-04  4.116007e-04
## ASV0633     -9.197873e-05 -9.596642e-05 -1.001093e-04 -1.044120e-04
## ASV0333      3.675170e-04  3.843837e-04  4.019958e-04  4.203838e-04
## ASV0966      2.792541e-04  2.920193e-04  3.053421e-04  3.192443e-04
## ASV1848      4.041248e-04  4.230635e-04  4.428741e-04  4.635951e-04
## ASV13390    -2.559599e-04 -2.674956e-04 -2.795210e-04 -2.920542e-04
## ASV14901    -2.559352e-04 -2.674686e-04 -2.794915e-04 -2.920220e-04
## ASV1676     -2.930679e-04 -3.059076e-04 -3.192593e-04 -3.331389e-04
## ASV1756     -3.083764e-05 -3.221028e-05 -3.363942e-05 -3.512696e-05
## ASV22537    -3.503912e-05 -3.650019e-05 -3.801276e-05 -3.957782e-05
## ASV3303     -4.589853e-06 -4.908269e-06 -5.249523e-06 -5.615191e-06
## ASV4030     -1.065605e-04 -1.112604e-04 -1.161504e-04 -1.212367e-04
## ASV4871      2.052992e-04  2.147570e-04  2.246358e-04  2.349530e-04
## ASV5536      1.267409e-05  1.325083e-05  1.385301e-05  1.448170e-05
## ASV5700      9.169504e-05  9.585031e-05  1.001836e-04  1.047014e-04
## ASV8957      1.674471e-04  1.742884e-04  1.813582e-04  1.886599e-04
## ASV11210     1.654656e-04  1.734944e-04  1.819177e-04  1.907551e-04
## ASV7585     -2.559258e-04 -2.674583e-04 -2.794803e-04 -2.920098e-04
## ASV8596     -2.559011e-04 -2.674313e-04 -2.794508e-04 -2.919777e-04
## ASV9532     -1.023057e-04 -1.067790e-04 -1.114296e-04 -1.162628e-04
## ASV4254      1.860008e-04  1.945922e-04  2.035675e-04  2.129427e-04
## ASV13299    -2.558793e-04 -2.674076e-04 -2.794250e-04 -2.919495e-04
## ASV15627    -2.558545e-04 -2.673806e-04 -2.793955e-04 -2.919173e-04
## ASV6302     -2.006956e-04 -2.088733e-04 -2.173265e-04 -2.260599e-04
## ASV3040      1.031333e-04  1.078362e-04  1.127436e-04  1.178634e-04
## ASV0632      2.101951e-04  2.198358e-04  2.299020e-04  2.404112e-04
## ASV3694      3.337731e-04  3.489190e-04  3.647173e-04  3.811929e-04
## ASV1592     -6.117554e-05 -6.357211e-05 -6.603914e-05 -6.857662e-05
## ASV0538      1.710152e-04  1.790400e-04  1.874366e-04  1.962220e-04
## ASV0832      3.726333e-04  3.894834e-04  4.070546e-04  4.253744e-04
## ASV0727      2.830002e-04  2.962473e-04  3.101031e-04  3.245947e-04
## ASV1165     -3.622702e-04 -3.788421e-04 -3.961409e-04 -4.141956e-04
## ASV1325      4.316435e-05  4.597705e-05  4.899032e-05  5.221924e-05
## ASV0819      6.499429e-04  6.796299e-04  7.106155e-04  7.429511e-04
## ASV2251      3.435512e-04  3.578512e-04  3.726532e-04  3.879664e-04
## ASV0100     -2.214019e-05 -2.309987e-05 -2.409642e-05 -2.513080e-05
## ASV0444     -1.733124e-04 -1.812431e-04 -1.895237e-04 -1.981686e-04
## ASV0800      8.448857e-04  8.822263e-04  9.210896e-04  9.615266e-04
## ASV2432      1.817628e-05  1.866547e-05  1.914802e-05  1.962160e-05
## ASV2883      2.295051e-05  2.376358e-05  2.459064e-05  2.543032e-05
## ASV3894      2.566288e-05  2.643186e-05  2.719800e-05  2.795798e-05
## ASV2367      5.928798e-04  6.196506e-04  6.475638e-04  6.766624e-04
## ASV3724     -3.520582e-04 -3.678132e-04 -3.842273e-04 -4.013241e-04
## ASV2112     -3.014945e-04 -3.152774e-04 -3.296627e-04 -3.446740e-04
## ASV3661      1.047649e-04  1.096768e-04  1.148152e-04  1.201904e-04
## ASV2096     -2.193464e-04 -2.296792e-04 -2.404891e-04 -2.517969e-04
## ASV3551     -2.513213e-04 -2.623821e-04 -2.738873e-04 -2.858510e-04
## ASV11343    -9.067870e-06 -9.633068e-06 -1.023703e-05 -1.088261e-05
## ASV2051      2.170159e-04  2.270482e-04  2.375326e-04  2.484886e-04
## ASV2617     -2.970136e-04 -3.104230e-04 -3.244040e-04 -3.389779e-04
## ASV0125     -1.317454e-04 -1.377716e-04 -1.440609e-04 -1.506234e-04
## ASV0372      4.526727e-04  4.731112e-04  4.944211e-04  5.166352e-04
## ASV6751     -3.376086e-04 -3.526616e-04 -3.683398e-04 -3.846650e-04
## ASV10810     7.586117e-05  7.932568e-05  8.294276e-05  8.671874e-05
## ASV0461     -1.938890e-04 -2.028692e-04 -2.122531e-04 -2.220578e-04
## ASV1945     -1.153179e-04 -1.207527e-04 -1.264403e-04 -1.323920e-04
## ASV0882     -9.993671e-05 -1.050277e-04 -1.103882e-04 -1.160330e-04
## ASV4040     -4.926415e-05 -5.149776e-05 -5.382570e-05 -5.625119e-05
## ASV0109     -3.224399e-06 -3.330517e-06 -3.437197e-06 -3.544053e-06
## ASV0174      1.499337e-04  1.560827e-04  1.624366e-04  1.689979e-04
## ASV2851      2.584021e-04  2.695283e-04  2.810794e-04  2.930668e-04
## ASV5312      4.397236e-05  4.595197e-05  4.801837e-05  5.017540e-05
## ASV9402     -3.621682e-04 -3.783977e-04 -3.953079e-04 -4.129231e-04
## ASV4870     -2.922580e-04 -3.052578e-04 -3.187944e-04 -3.328865e-04
## ASV0589      3.503678e-04  3.662475e-04  3.828099e-04  4.000811e-04
## ASV1221      9.624247e-07  1.046903e-06  1.138360e-06  1.237314e-06
## ASV6028     -3.388239e-04 -3.541270e-04 -3.700840e-04 -3.867195e-04
## ASV5106     -1.268265e-04 -1.323570e-04 -1.381059e-04 -1.440796e-04
## ASV4977     -4.776270e-05 -5.043468e-05 -5.326637e-05 -5.626770e-05
## ASV5715     -2.226717e-04 -2.327474e-04 -2.432552e-04 -2.542114e-04
## ASV4182      8.545715e-05  8.973295e-05  9.423056e-05  9.896203e-05
## ASV2383     -2.001227e-05 -2.138755e-05 -2.286620e-05 -2.445635e-05
## ASV3985      4.016256e-04  4.202858e-04  4.397909e-04  4.601770e-04
## ASV2787     -2.989122e-04 -3.119871e-04 -3.255837e-04 -3.397185e-04
## ASV6756     -2.592480e-04 -2.711525e-04 -2.835820e-04 -2.965574e-04
## ASV1634     -4.125136e-04 -4.307960e-04 -4.498272e-04 -4.696324e-04
## ASV0649     -1.269590e-04 -1.327660e-04 -1.388264e-04 -1.451501e-04
## ASV1591     -9.351732e-06 -1.018706e-05 -1.109353e-05 -1.207674e-05
## ASV1854      4.317255e-04  4.518566e-04  4.729045e-04  4.949088e-04
## ASV4205      2.878934e-04  3.013204e-04  3.153596e-04  3.300376e-04
## ASV3293     -1.649379e-04 -1.722322e-04 -1.798240e-04 -1.877235e-04
## ASV1631      1.947797e-04  2.036351e-04  2.128749e-04  2.225141e-04
## ASV1747     -1.118293e-04 -1.172098e-04 -1.228501e-04 -1.287625e-04
## ASV5634      8.818336e-05  9.217621e-05  9.634120e-05  1.006850e-04
## ASV0965     -1.386093e-04 -1.448173e-04 -1.512860e-04 -1.580248e-04
## ASV1094      2.392250e-04  2.499497e-04  2.611258e-04  2.727697e-04
## ASV2744     -9.525282e-06 -1.037553e-05 -1.129810e-05 -1.229869e-05
## ASV7212     -3.643703e-04 -3.812183e-04 -3.988191e-04 -4.172035e-04
## ASV0344     -2.407138e-04 -2.516488e-04 -2.630564e-04 -2.749549e-04
## ASV11812    -2.611993e-04 -2.732099e-04 -2.857516e-04 -2.988457e-04
## ASV7867     -3.832778e-05 -4.021177e-05 -4.218924e-05 -4.426476e-05
## ASV6670      2.347091e-04  2.448252e-04  2.553317e-04  2.662401e-04
## ASV10991     2.145329e-06  1.609836e-06  9.957359e-07  2.953306e-07
## ASV1281      4.685750e-04  4.906133e-04  5.136726e-04  5.377987e-04
## ASV12845    -2.611768e-04 -2.731852e-04 -2.857245e-04 -2.988160e-04
## ASV1833     -2.611511e-04 -2.731571e-04 -2.856937e-04 -2.987823e-04
## ASV2211      1.678816e-04  1.750961e-04  1.825861e-04  1.903592e-04
## ASV3920      3.654747e-04  3.816359e-04  3.984546e-04  4.159527e-04
## ASV4545     -2.968215e-04 -3.104960e-04 -3.247775e-04 -3.396910e-04
## ASV4710     -3.239378e-04 -3.388175e-04 -3.543540e-04 -3.705735e-04
## ASV4978      5.169439e-05  5.409381e-05  5.660166e-05  5.922255e-05
## ASV9630     -9.198164e-06 -9.653631e-06 -1.013196e-05 -1.063430e-05
## ASV9797     -1.058492e-05 -1.145366e-05 -1.239447e-05 -1.341311e-05
## ASV13469    -2.610819e-04 -2.730812e-04 -2.856106e-04 -2.986913e-04
## ASV14961    -9.522973e-05 -9.959078e-05 -1.041428e-04 -1.088934e-04
## ASV6259      1.454030e-04  1.517540e-04  1.583563e-04  1.652174e-04
## ASV6294     -1.859204e-04 -1.944720e-04 -2.034016e-04 -2.127246e-04
## ASV6883     -8.765444e-05 -9.182767e-05 -9.619779e-05 -1.007738e-04
## ASV7041     -2.166048e-04 -2.267882e-04 -2.374412e-04 -2.485842e-04
## ASV4363     -2.514902e-04 -2.626243e-04 -2.742138e-04 -2.862739e-04
## ASV1784     -3.680746e-04 -3.847732e-04 -4.021914e-04 -4.203568e-04
## ASV2140      3.303247e-05  3.459770e-05  3.623513e-05  3.794778e-05
## ASV3202      2.514513e-04  2.625819e-04  2.741675e-04  2.862234e-04
## ASV6017     -2.514274e-04 -2.625559e-04 -2.741391e-04 -2.861925e-04
## ASV9129      1.259962e-04  1.314564e-04  1.371283e-04  1.430177e-04
## ASV0917      2.579768e-04  2.694151e-04  2.813228e-04  2.937159e-04
## ASV10584    -2.393394e-06 -2.160865e-06 -1.889029e-06 -1.573991e-06
## ASV11218     1.631491e-04  1.702483e-04  1.776255e-04  1.852890e-04
## ASV11229     2.525984e-05  2.674209e-05  2.831698e-05  2.999040e-05
## ASV11604    -2.956758e-05 -3.106772e-05 -3.264652e-05 -3.430818e-05
## ASV2103     -2.958767e-04 -3.091300e-04 -3.229400e-04 -3.373267e-04
## ASV2165     -2.513604e-04 -2.624828e-04 -2.740595e-04 -2.861057e-04
## ASV2340      2.774320e-04  2.892735e-04  3.015592e-04  3.143007e-04
## ASV3738     -2.513326e-04 -2.624524e-04 -2.740264e-04 -2.860697e-04
## ASV4012      7.626891e-05  7.963528e-05  8.313779e-05  8.678083e-05
## ASV4094     -2.513126e-04 -2.624307e-04 -2.740027e-04 -2.860439e-04
## ASV4454     -2.512888e-04 -2.624047e-04 -2.739744e-04 -2.860130e-04
## ASV7031      6.049303e-05  6.343821e-05  6.652830e-05  6.977041e-05
## ASV7087     -9.508496e-05 -9.905241e-05 -1.031608e-04 -1.074130e-04
## ASV4159      1.453120e-05  1.510926e-05  1.570464e-05  1.631731e-05
## ASV5084     -2.512621e-04 -2.623757e-04 -2.739428e-04 -2.859788e-04
## ASV6584     -2.512383e-04 -2.623497e-04 -2.739145e-04 -2.859479e-04
## ASV9614     -2.512145e-04 -2.623238e-04 -2.738862e-04 -2.859171e-04
## ASV16068    -2.511907e-04 -2.622978e-04 -2.738580e-04 -2.858863e-04
## ASV2141     -3.318917e-04 -3.460259e-04 -3.606922e-04 -3.759052e-04
## ASV0395     -2.407804e-05 -2.525499e-05 -2.649091e-05 -2.778888e-05
## ASV5640     -5.948351e-05 -6.235120e-05 -6.535683e-05 -6.850686e-05
## ASV2854     -2.821065e-04 -2.944823e-04 -3.073546e-04 -3.207396e-04
## ASV3825     -4.995994e-04 -5.221379e-04 -5.456368e-04 -5.701322e-04
## ASV0481      5.414905e-04  5.651775e-04  5.898104e-04  6.154194e-04
## ASV3304      2.564351e-05  2.685924e-05  2.813254e-05  2.946613e-05
## ASV0445      3.307886e-04  3.455668e-04  3.609611e-04  3.769933e-04
## ASV1845     -1.751683e-04 -1.833374e-04 -1.918782e-04 -2.008064e-04
## ASV3110     -1.916778e-04 -2.002521e-04 -2.091883e-04 -2.185004e-04

Stats::glm - Client needs p-values for each bacteria

3226

R documentation: https://www.rdocumentation.org/packages/stats/versions/3.6.2/topics/glm

278 x 3226 ASVs

library(stats)

logreg <- stats::glm(as.factor(Clade) ~ . ,
                     data = lr_clr_df[,-1],
                     family = "binomial")
summary(logreg)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_df[, -1])
## 
## Coefficients: (2949 not defined because of singularities)
##               Estimate Std. Error    z value Pr(>|z|)    
## (Intercept) -2.880e+31  4.028e+22 -7.149e+08   <2e-16 ***
## ASV1236     -4.149e+34  1.535e+38  0.000e+00    1.000    
## ASV0421     -7.219e+33  1.502e+37  0.000e+00    1.000    
## ASV0691     -1.816e+35  4.601e+38  0.000e+00    1.000    
## ASV0899      2.866e+34  6.424e+37  0.000e+00    1.000    
## ASV1004      8.578e+32  1.052e+37  0.000e+00    1.000    
## ASV1041      3.840e+34  6.224e+37  1.000e-03    1.000    
## ASV1058      6.163e+34  1.644e+38  0.000e+00    1.000    
## ASV12542    -9.556e+34  1.808e+38 -1.000e-03    1.000    
## ASV1294      5.553e+34  1.377e+38  0.000e+00    1.000    
## ASV13113     1.161e+33  4.798e+36  0.000e+00    1.000    
## ASV1318      1.158e+34  1.613e+37  1.000e-03    0.999    
## ASV2269      1.568e+35  3.485e+38  0.000e+00    1.000    
## ASV2542     -8.830e+32  1.637e+36 -1.000e-03    1.000    
## ASV2660     -1.285e+35  3.058e+38  0.000e+00    1.000    
## ASV2737     -5.775e+34  1.922e+38  0.000e+00    1.000    
## ASV2840      1.919e+33  6.876e+36  0.000e+00    1.000    
## ASV3053      1.422e+34  2.018e+38  0.000e+00    1.000    
## ASV3077     -1.166e+35  3.957e+38  0.000e+00    1.000    
## ASV3134     -8.330e+31  3.634e+36  0.000e+00    1.000    
## ASV3140     -1.154e+34  1.880e+37 -1.000e-03    1.000    
## ASV3579     -6.390e+33  1.505e+37  0.000e+00    1.000    
## ASV6119             NA         NA         NA       NA    
## ASV7557             NA         NA         NA       NA    
## ASV8422             NA         NA         NA       NA    
## ASV1086             NA         NA         NA       NA    
## ASV1310      2.802e+34  3.158e+37  1.000e-03    0.999    
## ASV15750     1.307e+35  3.444e+38  0.000e+00    1.000    
## ASV16905            NA         NA         NA       NA    
## ASV2033     -1.608e+34  1.242e+37 -1.000e-03    0.999    
## ASV2089             NA         NA         NA       NA    
## ASV2127     -1.090e+34  4.184e+37  0.000e+00    1.000    
## ASV2725      2.892e+34  8.052e+37  0.000e+00    1.000    
## ASV2804             NA         NA         NA       NA    
## ASV3075      1.043e+34  2.681e+37  0.000e+00    1.000    
## ASV3327      2.417e+34  9.291e+37  0.000e+00    1.000    
## ASV3342     -9.806e+33  3.121e+37  0.000e+00    1.000    
## ASV3532     -1.473e+34  3.186e+37  0.000e+00    1.000    
## ASV3600     -7.428e+33  1.552e+37  0.000e+00    1.000    
## ASV4013      2.677e+34  2.153e+37  1.000e-03    0.999    
## ASV4136     -2.299e+34  8.747e+37  0.000e+00    1.000    
## ASV4195             NA         NA         NA       NA    
## ASV4407             NA         NA         NA       NA    
## ASV4717             NA         NA         NA       NA    
## ASV6794             NA         NA         NA       NA    
## ASV8324             NA         NA         NA       NA    
## ASV8981     -4.567e+33  1.680e+37  0.000e+00    1.000    
## ASV9859     -2.192e+33  2.132e+37  0.000e+00    1.000    
## ASV0936      1.234e+34  1.426e+37  1.000e-03    0.999    
## ASV12683            NA         NA         NA       NA    
## ASV1293      1.416e+34  3.309e+37  0.000e+00    1.000    
## ASV13055            NA         NA         NA       NA    
## ASV17063            NA         NA         NA       NA    
## ASV2228             NA         NA         NA       NA    
## ASV2769     -7.899e+34  1.269e+38 -1.000e-03    1.000    
## ASV2803     -8.155e+33  8.833e+37  0.000e+00    1.000    
## ASV2896     -1.485e+33  2.748e+36 -1.000e-03    1.000    
## ASV3062             NA         NA         NA       NA    
## ASV3107     -4.028e+31  1.982e+36  0.000e+00    1.000    
## ASV3265     -5.383e+31  2.193e+37  0.000e+00    1.000    
## ASV3666             NA         NA         NA       NA    
## ASV4497      9.538e+34  2.124e+38  0.000e+00    1.000    
## ASV6914             NA         NA         NA       NA    
## ASV0576      1.539e+35  3.360e+38  0.000e+00    1.000    
## ASV0673     -6.677e+34  1.355e+38  0.000e+00    1.000    
## ASV0772     -6.733e+34  7.108e+37 -1.000e-03    0.999    
## ASV0862             NA         NA         NA       NA    
## ASV0898             NA         NA         NA       NA    
## ASV0910     -4.105e+33  4.223e+36 -1.000e-03    0.999    
## ASV0964             NA         NA         NA       NA    
## ASV10059    -9.224e+32  5.249e+35 -2.000e-03    0.999    
## ASV10263            NA         NA         NA       NA    
## ASV1088     -9.203e+33  9.383e+36 -1.000e-03    0.999    
## ASV1101             NA         NA         NA       NA    
## ASV1183      8.080e+33  2.922e+37  0.000e+00    1.000    
## ASV11956            NA         NA         NA       NA    
## ASV12774            NA         NA         NA       NA    
## ASV1321             NA         NA         NA       NA    
## ASV13793            NA         NA         NA       NA    
## ASV14482            NA         NA         NA       NA    
## ASV15483            NA         NA         NA       NA    
## ASV2062             NA         NA         NA       NA    
## ASV2132      2.636e+33  7.287e+36  0.000e+00    1.000    
## ASV2413             NA         NA         NA       NA    
## ASV2490             NA         NA         NA       NA    
## ASV2594     -3.671e+33  3.510e+36 -1.000e-03    0.999    
## ASV2822             NA         NA         NA       NA    
## ASV2863             NA         NA         NA       NA    
## ASV2910             NA         NA         NA       NA    
## ASV2980     -1.018e+34  1.300e+37 -1.000e-03    0.999    
## ASV3307             NA         NA         NA       NA    
## ASV3474             NA         NA         NA       NA    
## ASV3502      1.174e+33  3.275e+37  0.000e+00    1.000    
## ASV4236             NA         NA         NA       NA    
## ASV4842             NA         NA         NA       NA    
## ASV4894             NA         NA         NA       NA    
## ASV5290             NA         NA         NA       NA    
## ASV5501      6.076e+33  5.417e+37  0.000e+00    1.000    
## ASV5795             NA         NA         NA       NA    
## ASV5987             NA         NA         NA       NA    
## ASV6267             NA         NA         NA       NA    
## ASV6862             NA         NA         NA       NA    
## ASV7145             NA         NA         NA       NA    
## ASV7673             NA         NA         NA       NA    
## ASV7789             NA         NA         NA       NA    
## ASV7809             NA         NA         NA       NA    
## ASV8002             NA         NA         NA       NA    
## ASV8205      1.721e+33  1.992e+36  1.000e-03    0.999    
## ASV9155             NA         NA         NA       NA    
## ASV9221     -4.034e+33  1.323e+37  0.000e+00    1.000    
## ASV9311             NA         NA         NA       NA    
## ASV9557             NA         NA         NA       NA    
## ASV9936             NA         NA         NA       NA    
## ASV1445      3.537e+33  1.047e+37  0.000e+00    1.000    
## ASV4232      2.474e+32  5.699e+36  0.000e+00    1.000    
## ASV6479     -3.591e+33  1.755e+37  0.000e+00    1.000    
## ASV0142     -6.407e+34  8.205e+37 -1.000e-03    0.999    
## ASV0378      4.944e+33  2.274e+37  0.000e+00    1.000    
## ASV1122      9.844e+33  5.743e+36  2.000e-03    0.999    
## ASV0123      1.174e+35  2.298e+38  1.000e-03    1.000    
## ASV2064      2.971e+34  2.632e+37  1.000e-03    0.999    
## ASV4459     -4.566e+33  3.147e+37  0.000e+00    1.000    
## ASV0448      8.855e+32  4.021e+36  0.000e+00    1.000    
## ASV0397      5.454e+33  3.225e+36  2.000e-03    0.999    
## ASV0485     -6.123e+32  8.358e+35 -1.000e-03    0.999    
## ASV1566             NA         NA         NA       NA    
## ASV1365      1.345e+34  1.281e+37  1.000e-03    0.999    
## ASV1065     -6.132e+33  1.217e+37 -1.000e-03    1.000    
## ASV0722      1.223e+34  5.077e+37  0.000e+00    1.000    
## ASV12660            NA         NA         NA       NA    
## ASV0223      9.326e+31  2.937e+36  0.000e+00    1.000    
## ASV0229      2.406e+32  2.545e+37  0.000e+00    1.000    
## ASV0877      1.559e+34  2.751e+37  1.000e-03    1.000    
## ASV0983      3.222e+33  4.074e+37  0.000e+00    1.000    
## ASV0626             NA         NA         NA       NA    
## ASV4146      1.191e+33  1.873e+37  0.000e+00    1.000    
## ASV4175     -1.192e+34  6.769e+37  0.000e+00    1.000    
## ASV2082     -1.738e+33  4.065e+37  0.000e+00    1.000    
## ASV2272      1.819e+33  2.927e+36  1.000e-03    1.000    
## ASV2245      4.247e+34  1.112e+38  0.000e+00    1.000    
## ASV0590             NA         NA         NA       NA    
## ASV0217      9.857e+33  1.205e+37  1.000e-03    0.999    
## ASV0416     -5.675e+33  5.779e+36 -1.000e-03    0.999    
## ASV1056     -6.651e+33  1.592e+37  0.000e+00    1.000    
## ASV7777      1.979e+32  3.526e+35  1.000e-03    1.000    
## ASV0455      1.312e+33  1.582e+36  1.000e-03    0.999    
## ASV0604             NA         NA         NA       NA    
## ASV6100      5.758e+32  1.493e+36  0.000e+00    1.000    
## ASV11359    -1.696e+34  2.293e+37 -1.000e-03    0.999    
## ASV6604      8.731e+33  2.177e+37  0.000e+00    1.000    
## ASV5004     -5.365e+33  2.712e+37  0.000e+00    1.000    
## ASV1483      6.759e+33  2.523e+37  0.000e+00    1.000    
## ASV9773     -2.517e+32  8.033e+35  0.000e+00    1.000    
## ASV4059      3.719e+33  7.644e+36  0.000e+00    1.000    
## ASV1193      2.993e+32  6.384e+36  0.000e+00    1.000    
## ASV4610             NA         NA         NA       NA    
## ASV0742             NA         NA         NA       NA    
## ASV1502     -1.217e+34  3.605e+37  0.000e+00    1.000    
## ASV0195      3.770e+33  1.284e+37  0.000e+00    1.000    
## ASV1213      1.528e+34  3.933e+37  0.000e+00    1.000    
## ASV1648     -3.924e+33  1.206e+37  0.000e+00    1.000    
## ASV6984     -1.787e+33  3.578e+36  0.000e+00    1.000    
## ASV0396     -6.942e+33  4.986e+36 -1.000e-03    0.999    
## ASV4297             NA         NA         NA       NA    
## ASV2622     -4.331e+33  1.160e+37  0.000e+00    1.000    
## ASV3512      1.858e+33  7.366e+36  0.000e+00    1.000    
## ASV2411             NA         NA         NA       NA    
## ASV2291             NA         NA         NA       NA    
## ASV0807     -4.121e+33  3.065e+36 -1.000e-03    0.999    
## ASV1292      6.169e+33  2.642e+37  0.000e+00    1.000    
## ASV1035             NA         NA         NA       NA    
## ASV0070     -2.231e+33  3.194e+36 -1.000e-03    0.999    
## ASV0255      5.166e+32  1.279e+37  0.000e+00    1.000    
## ASV0057      1.611e+33  3.419e+36  0.000e+00    1.000    
## ASV0077     -9.392e+32  9.182e+35 -1.000e-03    0.999    
## ASV0625      6.430e+33  2.133e+37  0.000e+00    1.000    
## ASV2464             NA         NA         NA       NA    
## ASV1315      1.155e+34  3.160e+37  0.000e+00    1.000    
## ASV2673      1.270e+33  3.223e+36  0.000e+00    1.000    
## ASV2161     -1.158e+34  3.815e+37  0.000e+00    1.000    
## ASV0337      7.970e+33  2.902e+37  0.000e+00    1.000    
## ASV7680     -2.264e+33  9.480e+36  0.000e+00    1.000    
## ASV0611     -9.620e+32  5.105e+35 -2.000e-03    0.998    
## ASV3118     -4.495e+33  2.661e+37  0.000e+00    1.000    
## ASV1284      3.493e+33  1.980e+37  0.000e+00    1.000    
## ASV0889             NA         NA         NA       NA    
## ASV4649     -1.280e+34  3.889e+37  0.000e+00    1.000    
## ASV1108      1.812e+32  3.438e+36  0.000e+00    1.000    
## ASV0738     -4.827e+33  1.311e+37  0.000e+00    1.000    
## ASV0473     -4.647e+32  5.244e+36  0.000e+00    1.000    
## ASV0598             NA         NA         NA       NA    
## ASV0429      1.390e+34  3.535e+37  0.000e+00    1.000    
## ASV1549     -1.292e+33  7.928e+36  0.000e+00    1.000    
## ASV1203      3.030e+33  9.238e+36  0.000e+00    1.000    
## ASV4532      5.620e+33  5.879e+36  1.000e-03    0.999    
## ASV0274      6.311e+33  5.906e+36  1.000e-03    0.999    
## ASV0163      9.020e+33  2.429e+37  0.000e+00    1.000    
## ASV1298     -1.716e+33  2.629e+36 -1.000e-03    0.999    
## ASV9424      1.117e+34  3.245e+37  0.000e+00    1.000    
## ASV0412      1.676e+33  1.091e+37  0.000e+00    1.000    
## ASV0284     -2.095e+33  1.114e+37  0.000e+00    1.000    
## ASV0620             NA         NA         NA       NA    
## ASV0153     -1.081e+33  2.380e+36  0.000e+00    1.000    
## ASV0498      2.773e+32  3.417e+36  0.000e+00    1.000    
## ASV0097     -1.844e+32  9.372e+36  0.000e+00    1.000    
## ASV0104      9.679e+32  1.261e+37  0.000e+00    1.000    
## ASV1282      2.504e+33  2.191e+37  0.000e+00    1.000    
## ASV3883     -1.801e+33  1.147e+37  0.000e+00    1.000    
## ASV0801      1.600e+33  6.103e+36  0.000e+00    1.000    
## ASV1611      4.351e+33  2.600e+37  0.000e+00    1.000    
## ASV0227      2.934e+33  1.486e+37  0.000e+00    1.000    
## ASV0833             NA         NA         NA       NA    
## ASV0718      2.498e+33  1.003e+37  0.000e+00    1.000    
## ASV1139             NA         NA         NA       NA    
## ASV0766     -1.056e+34  2.123e+37  0.000e+00    1.000    
## ASV2091     -5.558e+33  3.367e+37  0.000e+00    1.000    
## ASV1238      8.848e+33  1.400e+37  1.000e-03    0.999    
## ASV9193             NA         NA         NA       NA    
## ASV0290     -9.339e+33  3.123e+37  0.000e+00    1.000    
## ASV0231     -2.711e+33  6.415e+36  0.000e+00    1.000    
## ASV0185      2.305e+32  5.670e+35  0.000e+00    1.000    
## ASV2330             NA         NA         NA       NA    
## ASV3119      1.692e+33  1.477e+36  1.000e-03    0.999    
## ASV2368      2.026e+32  6.353e+35  0.000e+00    1.000    
## ASV0122     -4.592e+33  7.572e+36 -1.000e-03    1.000    
## ASV1044     -1.369e+33  2.475e+36 -1.000e-03    1.000    
## ASV0160     -1.445e+33  3.484e+36  0.000e+00    1.000    
## ASV0326     -1.080e+33  3.289e+36  0.000e+00    1.000    
## ASV1388      2.024e+33  2.040e+36  1.000e-03    0.999    
## ASV0792             NA         NA         NA       NA    
## ASV0036     -3.690e+33  1.838e+36 -2.000e-03    0.998    
## ASV2125     -3.618e+32  3.351e+36  0.000e+00    1.000    
## ASV1075      3.311e+33  3.863e+36  1.000e-03    0.999    
## ASV0390     -3.747e+32  1.204e+36  0.000e+00    1.000    
## ASV3790      1.588e+33  5.729e+36  0.000e+00    1.000    
## ASV1535     -6.395e+33  1.860e+37  0.000e+00    1.000    
## ASV0263             NA         NA         NA       NA    
## ASV0675     -5.435e+32  5.894e+36  0.000e+00    1.000    
## ASV3348     -2.178e+33  6.196e+36  0.000e+00    1.000    
## ASV0058     -1.205e+33  1.569e+36 -1.000e-03    0.999    
## ASV4142             NA         NA         NA       NA    
## ASV0059      7.130e+32  8.228e+35  1.000e-03    0.999    
## ASV0013     -7.786e+32  1.535e+37  0.000e+00    1.000    
## ASV0033      5.192e+33  8.043e+36  1.000e-03    0.999    
## ASV4354             NA         NA         NA       NA    
## ASV0022     -1.866e+33  1.244e+37  0.000e+00    1.000    
## ASV0134      6.838e+32  2.711e+36  0.000e+00    1.000    
## ASV0415     -2.899e+33  9.763e+36  0.000e+00    1.000    
## ASV10103            NA         NA         NA       NA    
## ASV1613     -2.181e+32  5.743e+36  0.000e+00    1.000    
## ASV0135      1.180e+31  4.180e+35  0.000e+00    1.000    
## ASV0469             NA         NA         NA       NA    
## ASV0471     -3.078e+33  1.214e+37  0.000e+00    1.000    
## ASV0451      8.272e+32  3.247e+36  0.000e+00    1.000    
## ASV0747      2.441e+32  8.929e+35  0.000e+00    1.000    
## ASV1314     -3.204e+33  1.057e+37  0.000e+00    1.000    
## ASV0425             NA         NA         NA       NA    
## ASV0559     -1.133e+34  2.062e+37 -1.000e-03    1.000    
## ASV0148      2.372e+33  6.980e+36  0.000e+00    1.000    
## ASV0129     -1.963e+33  6.923e+36  0.000e+00    1.000    
## ASV1072     -5.392e+33  1.062e+37 -1.000e-03    1.000    
## ASV2390             NA         NA         NA       NA    
## ASV0548     -4.313e+33  7.294e+36 -1.000e-03    1.000    
## ASV0168     -5.128e+32  4.090e+35 -1.000e-03    0.999    
## ASV0066      1.635e+32  1.353e+36  0.000e+00    1.000    
## ASV0468      1.984e+33  7.011e+36  0.000e+00    1.000    
## ASV0172      8.945e+32  1.315e+36  1.000e-03    0.999    
## ASV0236     -2.539e+32  4.912e+36  0.000e+00    1.000    
## ASV0250     -1.591e+33  7.658e+36  0.000e+00    1.000    
## ASV0338      2.069e+33  1.067e+37  0.000e+00    1.000    
## ASV0450     -6.260e+33  1.353e+37  0.000e+00    1.000    
## ASV0377             NA         NA         NA       NA    
## ASV1022     -1.757e+32  5.718e+35  0.000e+00    1.000    
## ASV6174             NA         NA         NA       NA    
## ASV0786             NA         NA         NA       NA    
## ASV0053     -2.458e+32  6.897e+35  0.000e+00    1.000    
## ASV0697      5.065e+32  6.094e+36  0.000e+00    1.000    
## ASV0785     -1.641e+33  5.283e+36  0.000e+00    1.000    
## ASV1967     -6.916e+33  1.717e+37  0.000e+00    1.000    
## ASV0385     -1.327e+32  1.278e+36  0.000e+00    1.000    
## ASV0295      2.275e+32  7.441e+35  0.000e+00    1.000    
## ASV0072      1.094e+33  6.490e+35  2.000e-03    0.999    
## ASV0157      1.506e+33  3.159e+36  0.000e+00    1.000    
## ASV0501     -6.608e+33  6.836e+36 -1.000e-03    0.999    
## ASV10729    -1.330e+33  1.838e+36 -1.000e-03    0.999    
## ASV1470             NA         NA         NA       NA    
## ASV0050     -2.124e+33  2.917e+37  0.000e+00    1.000    
## ASV0411     -4.211e+32  5.668e+36  0.000e+00    1.000    
## ASV0549      8.365e+32  9.417e+36  0.000e+00    1.000    
## ASV0184      3.552e+30  3.283e+33  1.000e-03    0.999    
## ASV0705     -1.760e+33  8.082e+36  0.000e+00    1.000    
## ASV1715     -1.248e+33  6.190e+36  0.000e+00    1.000    
## ASV0603     -9.083e+32  1.139e+37  0.000e+00    1.000    
## ASV0826             NA         NA         NA       NA    
## ASV0034     -1.386e+33  1.969e+36 -1.000e-03    0.999    
## ASV0838      2.176e+33  6.071e+36  0.000e+00    1.000    
## ASV0614     -7.819e+30  4.586e+36  0.000e+00    1.000    
## ASV0014     -5.161e+33  1.300e+37  0.000e+00    1.000    
## ASV0585             NA         NA         NA       NA    
## ASV0016      3.864e+33  1.236e+37  0.000e+00    1.000    
## ASV5394      4.902e+31  4.740e+35  0.000e+00    1.000    
## ASV0666             NA         NA         NA       NA    
## ASV2085             NA         NA         NA       NA    
## ASV0003      3.287e+33  3.029e+37  0.000e+00    1.000    
## ASV0346      9.616e+32  7.383e+36  0.000e+00    1.000    
## ASV0267     -1.085e+33  2.773e+36  0.000e+00    1.000    
## ASV0353      1.676e+33  8.754e+35  2.000e-03    0.998    
## ASV2419     -2.316e+33  5.407e+36  0.000e+00    1.000    
## ASV0447             NA         NA         NA       NA    
## ASV0654             NA         NA         NA       NA    
## ASV0151     -2.449e+33  6.167e+36  0.000e+00    1.000    
## ASV0065      1.032e+33  1.086e+36  1.000e-03    0.999    
## ASV0527      6.130e+32  3.240e+36  0.000e+00    1.000    
## ASV4055             NA         NA         NA       NA    
## ASV0166             NA         NA         NA       NA    
## ASV0417     -6.496e+32  5.489e+35 -1.000e-03    0.999    
## ASV0078      7.887e+31  3.304e+36  0.000e+00    1.000    
## ASV0322             NA         NA         NA       NA    
## ASV0156     -2.074e+33  3.486e+36 -1.000e-03    1.000    
## ASV0648             NA         NA         NA       NA    
## ASV0407     -1.864e+32  1.218e+36  0.000e+00    1.000    
## ASV2030             NA         NA         NA       NA    
## ASV0300      9.106e+32  2.310e+36  0.000e+00    1.000    
## ASV1150     -2.376e+32  3.940e+36  0.000e+00    1.000    
## ASV0958     -2.550e+32  1.401e+36  0.000e+00    1.000    
## ASV0216             NA         NA         NA       NA    
## ASV0446      4.933e+32  2.747e+36  0.000e+00    1.000    
## ASV0367             NA         NA         NA       NA    
## ASV0200             NA         NA         NA       NA    
## ASV0334             NA         NA         NA       NA    
## ASV1311             NA         NA         NA       NA    
## ASV0458             NA         NA         NA       NA    
## ASV1371             NA         NA         NA       NA    
## ASV0418             NA         NA         NA       NA    
## ASV0004      1.822e+32  7.542e+36  0.000e+00    1.000    
## ASV1943             NA         NA         NA       NA    
## ASV1495     -3.254e+31  3.057e+35  0.000e+00    1.000    
## ASV0901             NA         NA         NA       NA    
## ASV0628             NA         NA         NA       NA    
## ASV0400             NA         NA         NA       NA    
## ASV0116             NA         NA         NA       NA    
## ASV0788     -3.770e+33  4.419e+36 -1.000e-03    0.999    
## ASV0117      1.331e+31  1.230e+36  0.000e+00    1.000    
## ASV3137             NA         NA         NA       NA    
## ASV0001             NA         NA         NA       NA    
## ASV1651     -4.041e+32  6.179e+35 -1.000e-03    0.999    
## ASV1692             NA         NA         NA       NA    
## ASV0660             NA         NA         NA       NA    
## ASV0508             NA         NA         NA       NA    
## ASV1660             NA         NA         NA       NA    
## ASV0233             NA         NA         NA       NA    
## ASV1343             NA         NA         NA       NA    
## ASV0209             NA         NA         NA       NA    
## ASV0193             NA         NA         NA       NA    
## ASV0357     -3.118e+33  1.580e+37  0.000e+00    1.000    
## ASV0198             NA         NA         NA       NA    
## ASV0007             NA         NA         NA       NA    
## ASV1772             NA         NA         NA       NA    
## ASV0009             NA         NA         NA       NA    
## ASV0006             NA         NA         NA       NA    
## ASV0011             NA         NA         NA       NA    
## ASV0015             NA         NA         NA       NA    
## ASV0017             NA         NA         NA       NA    
## ASV0235             NA         NA         NA       NA    
## ASV0382     -7.891e+32  2.685e+36  0.000e+00    1.000    
## ASV2357             NA         NA         NA       NA    
## ASV0567             NA         NA         NA       NA    
## ASV0165             NA         NA         NA       NA    
## ASV0005             NA         NA         NA       NA    
## ASV0384             NA         NA         NA       NA    
## ASV0002             NA         NA         NA       NA    
## ASV3017             NA         NA         NA       NA    
## ASV0091      1.698e+33  1.597e+36  1.000e-03    0.999    
## ASV0186             NA         NA         NA       NA    
## ASV0370             NA         NA         NA       NA    
## ASV0018             NA         NA         NA       NA    
## ASV1377             NA         NA         NA       NA    
## ASV0019             NA         NA         NA       NA    
## ASV0023             NA         NA         NA       NA    
## ASV2194             NA         NA         NA       NA    
## ASV1155             NA         NA         NA       NA    
## ASV0510             NA         NA         NA       NA    
## ASV2371             NA         NA         NA       NA    
## ASV0024             NA         NA         NA       NA    
## ASV2452             NA         NA         NA       NA    
## ASV2332             NA         NA         NA       NA    
## ASV2591             NA         NA         NA       NA    
## ASV0521             NA         NA         NA       NA    
## ASV5542             NA         NA         NA       NA    
## ASV0336             NA         NA         NA       NA    
## ASV10102            NA         NA         NA       NA    
## ASV16823            NA         NA         NA       NA    
## ASV3104             NA         NA         NA       NA    
## ASV0781             NA         NA         NA       NA    
## ASV10899            NA         NA         NA       NA    
## ASV11222            NA         NA         NA       NA    
## ASV11327            NA         NA         NA       NA    
## ASV12458            NA         NA         NA       NA    
## ASV1636             NA         NA         NA       NA    
## ASV1890             NA         NA         NA       NA    
## ASV2898             NA         NA         NA       NA    
## ASV8328             NA         NA         NA       NA    
## ASV0709             NA         NA         NA       NA    
## ASV0856             NA         NA         NA       NA    
## ASV0909             NA         NA         NA       NA    
## ASV0937             NA         NA         NA       NA    
## ASV11390            NA         NA         NA       NA    
## ASV11966            NA         NA         NA       NA    
## ASV12990            NA         NA         NA       NA    
## ASV14797            NA         NA         NA       NA    
## ASV14904            NA         NA         NA       NA    
## ASV15304            NA         NA         NA       NA    
## ASV16696            NA         NA         NA       NA    
## ASV1690             NA         NA         NA       NA    
## ASV2029             NA         NA         NA       NA    
## ASV2834             NA         NA         NA       NA    
## ASV4003             NA         NA         NA       NA    
## ASV4064             NA         NA         NA       NA    
## ASV4294             NA         NA         NA       NA    
## ASV4609             NA         NA         NA       NA    
## ASV6283             NA         NA         NA       NA    
## ASV6491             NA         NA         NA       NA    
## ASV7453             NA         NA         NA       NA    
## ASV7959             NA         NA         NA       NA    
## ASV8219             NA         NA         NA       NA    
## ASV8547             NA         NA         NA       NA    
## ASV9319             NA         NA         NA       NA    
## ASV9382             NA         NA         NA       NA    
## ASV11516            NA         NA         NA       NA    
## ASV14377            NA         NA         NA       NA    
## ASV1867             NA         NA         NA       NA    
## ASV1895             NA         NA         NA       NA    
## ASV3168             NA         NA         NA       NA    
## ASV4449             NA         NA         NA       NA    
## ASV6596             NA         NA         NA       NA    
## ASV7492             NA         NA         NA       NA    
## ASV9854             NA         NA         NA       NA    
## ASV6296             NA         NA         NA       NA    
## ASV4201             NA         NA         NA       NA    
## ASV0552             NA         NA         NA       NA    
## ASV3671             NA         NA         NA       NA    
## ASV3529             NA         NA         NA       NA    
## ASV1060             NA         NA         NA       NA    
## ASV0239             NA         NA         NA       NA    
## ASV5711             NA         NA         NA       NA    
## ASV4152             NA         NA         NA       NA    
## ASV1461             NA         NA         NA       NA    
## ASV2877             NA         NA         NA       NA    
## ASV0012             NA         NA         NA       NA    
## ASV9823             NA         NA         NA       NA    
## ASV0008             NA         NA         NA       NA    
## ASV7832             NA         NA         NA       NA    
## ASV1915             NA         NA         NA       NA    
## ASV0055             NA         NA         NA       NA    
## ASV0032             NA         NA         NA       NA    
## ASV2977             NA         NA         NA       NA    
## ASV0466             NA         NA         NA       NA    
## ASV3866             NA         NA         NA       NA    
## ASV0040             NA         NA         NA       NA    
## ASV0496             NA         NA         NA       NA    
## ASV0052             NA         NA         NA       NA    
## ASV3828             NA         NA         NA       NA    
## ASV1930             NA         NA         NA       NA    
## ASV2126             NA         NA         NA       NA    
## ASV0793             NA         NA         NA       NA    
## ASV0299             NA         NA         NA       NA    
## ASV0208             NA         NA         NA       NA    
## ASV0511             NA         NA         NA       NA    
## ASV1123             NA         NA         NA       NA    
## ASV0099             NA         NA         NA       NA    
## ASV0752             NA         NA         NA       NA    
## ASV0883             NA         NA         NA       NA    
## ASV0683             NA         NA         NA       NA    
## ASV4117             NA         NA         NA       NA    
## ASV2172             NA         NA         NA       NA    
## ASV0330             NA         NA         NA       NA    
## ASV0728             NA         NA         NA       NA    
## ASV0499             NA         NA         NA       NA    
## ASV0120             NA         NA         NA       NA    
## ASV1446             NA         NA         NA       NA    
## ASV17171            NA         NA         NA       NA    
## ASV0533             NA         NA         NA       NA    
## ASV2495             NA         NA         NA       NA    
## ASV5582             NA         NA         NA       NA    
## ASV1488             NA         NA         NA       NA    
## ASV0682             NA         NA         NA       NA    
## ASV0068             NA         NA         NA       NA    
## ASV1987             NA         NA         NA       NA    
## ASV0035             NA         NA         NA       NA    
## ASV7192             NA         NA         NA       NA    
## ASV0873             NA         NA         NA       NA    
## ASV4749             NA         NA         NA       NA    
## ASV2174             NA         NA         NA       NA    
## ASV1476             NA         NA         NA       NA    
## ASV0740             NA         NA         NA       NA    
## ASV0170             NA         NA         NA       NA    
## ASV2466             NA         NA         NA       NA    
## ASV1709             NA         NA         NA       NA    
## ASV6170             NA         NA         NA       NA    
## ASV3673             NA         NA         NA       NA    
## ASV1745             NA         NA         NA       NA    
## ASV0380      2.198e+33  9.375e+36  0.000e+00    1.000    
## ASV0426             NA         NA         NA       NA    
## ASV0202             NA         NA         NA       NA    
## ASV6350             NA         NA         NA       NA    
## ASV0713             NA         NA         NA       NA    
## ASV1822             NA         NA         NA       NA    
## ASV4569             NA         NA         NA       NA    
## ASV0030             NA         NA         NA       NA    
## ASV0331             NA         NA         NA       NA    
## ASV2981             NA         NA         NA       NA    
## ASV0828             NA         NA         NA       NA    
## ASV2440             NA         NA         NA       NA    
## ASV3006             NA         NA         NA       NA    
## ASV3875             NA         NA         NA       NA    
## ASV4511             NA         NA         NA       NA    
## ASV4700             NA         NA         NA       NA    
## ASV5804             NA         NA         NA       NA    
## ASV6826             NA         NA         NA       NA    
## ASV7280             NA         NA         NA       NA    
## ASV7535             NA         NA         NA       NA    
## ASV0651             NA         NA         NA       NA    
## ASV0913             NA         NA         NA       NA    
## ASV10832            NA         NA         NA       NA    
## ASV1117             NA         NA         NA       NA    
## ASV11329            NA         NA         NA       NA    
## ASV13209            NA         NA         NA       NA    
## ASV1345             NA         NA         NA       NA    
## ASV1719             NA         NA         NA       NA    
## ASV1886             NA         NA         NA       NA    
## ASV2158             NA         NA         NA       NA    
## ASV2189             NA         NA         NA       NA    
## ASV2257             NA         NA         NA       NA    
## ASV2283             NA         NA         NA       NA    
## ASV2328             NA         NA         NA       NA    
## ASV2434             NA         NA         NA       NA    
## ASV2648             NA         NA         NA       NA    
## ASV2698             NA         NA         NA       NA    
## ASV2775             NA         NA         NA       NA    
## ASV3171             NA         NA         NA       NA    
## ASV3227             NA         NA         NA       NA    
## ASV3397             NA         NA         NA       NA    
## ASV3444             NA         NA         NA       NA    
## ASV3556             NA         NA         NA       NA    
## ASV3606             NA         NA         NA       NA    
## ASV4190             NA         NA         NA       NA    
## ASV4197             NA         NA         NA       NA    
## ASV4722             NA         NA         NA       NA    
## ASV4765             NA         NA         NA       NA    
## ASV4809             NA         NA         NA       NA    
## ASV4846             NA         NA         NA       NA    
## ASV4903             NA         NA         NA       NA    
## ASV4944             NA         NA         NA       NA    
## ASV5151             NA         NA         NA       NA    
## ASV5413             NA         NA         NA       NA    
## ASV5537             NA         NA         NA       NA    
## ASV5688             NA         NA         NA       NA    
## ASV5752             NA         NA         NA       NA    
## ASV6122             NA         NA         NA       NA    
## ASV6135             NA         NA         NA       NA    
## ASV6188             NA         NA         NA       NA    
## ASV6216             NA         NA         NA       NA    
## ASV6242             NA         NA         NA       NA    
## ASV6383             NA         NA         NA       NA    
## ASV6781             NA         NA         NA       NA    
## ASV6799             NA         NA         NA       NA    
## ASV7374             NA         NA         NA       NA    
## ASV7539             NA         NA         NA       NA    
## ASV8591             NA         NA         NA       NA    
## ASV8637             NA         NA         NA       NA    
## ASV12796            NA         NA         NA       NA    
## ASV1934             NA         NA         NA       NA    
## ASV22549            NA         NA         NA       NA    
## ASV29857            NA         NA         NA       NA    
## ASV3215             NA         NA         NA       NA    
## ASV3236             NA         NA         NA       NA    
## ASV3954             NA         NA         NA       NA    
## ASV4850             NA         NA         NA       NA    
## ASV5225             NA         NA         NA       NA    
## ASV5532             NA         NA         NA       NA    
## ASV7258             NA         NA         NA       NA    
## ASV9474             NA         NA         NA       NA    
## ASV11857            NA         NA         NA       NA    
## ASV1202             NA         NA         NA       NA    
## ASV14742            NA         NA         NA       NA    
## ASV16652            NA         NA         NA       NA    
## ASV2019             NA         NA         NA       NA    
## ASV2410             NA         NA         NA       NA    
## ASV2718             NA         NA         NA       NA    
## ASV2738             NA         NA         NA       NA    
## ASV2876             NA         NA         NA       NA    
## ASV3177             NA         NA         NA       NA    
## ASV4367             NA         NA         NA       NA    
## ASV4635             NA         NA         NA       NA    
## ASV4896             NA         NA         NA       NA    
## ASV4907             NA         NA         NA       NA    
## ASV5230             NA         NA         NA       NA    
## ASV6509             NA         NA         NA       NA    
## ASV7376             NA         NA         NA       NA    
## ASV8163             NA         NA         NA       NA    
## ASV8195             NA         NA         NA       NA    
## ASV8923             NA         NA         NA       NA    
## ASV9666             NA         NA         NA       NA    
## ASV1482             NA         NA         NA       NA    
## ASV2726             NA         NA         NA       NA    
## ASV3281             NA         NA         NA       NA    
## ASV4235             NA         NA         NA       NA    
## ASV4808             NA         NA         NA       NA    
## ASV4861             NA         NA         NA       NA    
## ASV5276             NA         NA         NA       NA    
## ASV5837             NA         NA         NA       NA    
## ASV7098             NA         NA         NA       NA    
## ASV8451             NA         NA         NA       NA    
## ASV8694             NA         NA         NA       NA    
## ASV0905             NA         NA         NA       NA    
## ASV2900             NA         NA         NA       NA    
## ASV3963             NA         NA         NA       NA    
## ASV0041             NA         NA         NA       NA    
## ASV1865             NA         NA         NA       NA    
## ASV1140             NA         NA         NA       NA    
## ASV1179             NA         NA         NA       NA    
## ASV0279             NA         NA         NA       NA    
## ASV0043             NA         NA         NA       NA    
## ASV2097             NA         NA         NA       NA    
## ASV0309             NA         NA         NA       NA    
## ASV0607             NA         NA         NA       NA    
## ASV0025             NA         NA         NA       NA    
## ASV2284             NA         NA         NA       NA    
## ASV0556             NA         NA         NA       NA    
## ASV5040             NA         NA         NA       NA    
## ASV2924             NA         NA         NA       NA    
## ASV1331             NA         NA         NA       NA    
## ASV0506             NA         NA         NA       NA    
## ASV1514             NA         NA         NA       NA    
## ASV2144             NA         NA         NA       NA    
## ASV2265             NA         NA         NA       NA    
## ASV5156             NA         NA         NA       NA    
## ASV5534             NA         NA         NA       NA    
## ASV5747             NA         NA         NA       NA    
## ASV6657             NA         NA         NA       NA    
## ASV0658             NA         NA         NA       NA    
## ASV0716             NA         NA         NA       NA    
## ASV1657             NA         NA         NA       NA    
## ASV1885             NA         NA         NA       NA    
## ASV2333             NA         NA         NA       NA    
## ASV3375             NA         NA         NA       NA    
## ASV4317             NA         NA         NA       NA    
## ASV9599             NA         NA         NA       NA    
## ASV0175     -3.581e+31  5.063e+36  0.000e+00    1.000    
## ASV1032             NA         NA         NA       NA    
## ASV1235             NA         NA         NA       NA    
## ASV1262             NA         NA         NA       NA    
## ASV1320             NA         NA         NA       NA    
## ASV13797            NA         NA         NA       NA    
## ASV1491             NA         NA         NA       NA    
## ASV15014            NA         NA         NA       NA    
## ASV1510             NA         NA         NA       NA    
## ASV1551             NA         NA         NA       NA    
## ASV1919             NA         NA         NA       NA    
## ASV2114             NA         NA         NA       NA    
## ASV21486            NA         NA         NA       NA    
## ASV2448             NA         NA         NA       NA    
## ASV2589             NA         NA         NA       NA    
## ASV2608             NA         NA         NA       NA    
## ASV2786             NA         NA         NA       NA    
## ASV2827             NA         NA         NA       NA    
## ASV2872             NA         NA         NA       NA    
## ASV3125             NA         NA         NA       NA    
## ASV3247             NA         NA         NA       NA    
## ASV3451             NA         NA         NA       NA    
## ASV3465             NA         NA         NA       NA    
## ASV3809             NA         NA         NA       NA    
## ASV4006             NA         NA         NA       NA    
## ASV4046             NA         NA         NA       NA    
## ASV4938             NA         NA         NA       NA    
## ASV5435             NA         NA         NA       NA    
## ASV5605             NA         NA         NA       NA    
## ASV5635             NA         NA         NA       NA    
## ASV5743             NA         NA         NA       NA    
## ASV6627             NA         NA         NA       NA    
## ASV6785             NA         NA         NA       NA    
## ASV7368             NA         NA         NA       NA    
## ASV9118             NA         NA         NA       NA    
## ASV9135             NA         NA         NA       NA    
## ASV9435             NA         NA         NA       NA    
## ASV9671             NA         NA         NA       NA    
## ASV0387             NA         NA         NA       NA    
## ASV0454             NA         NA         NA       NA    
## ASV0751             NA         NA         NA       NA    
## ASV1081             NA         NA         NA       NA    
## ASV1332             NA         NA         NA       NA    
## ASV2659             NA         NA         NA       NA    
## ASV2979             NA         NA         NA       NA    
## ASV4184             NA         NA         NA       NA    
## ASV6198             NA         NA         NA       NA    
## ASV7454             NA         NA         NA       NA    
## ASV8198             NA         NA         NA       NA    
## ASV0855             NA         NA         NA       NA    
## ASV10092            NA         NA         NA       NA    
## ASV1532             NA         NA         NA       NA    
## ASV2553             NA         NA         NA       NA    
## ASV2741             NA         NA         NA       NA    
## ASV4095             NA         NA         NA       NA    
## ASV5295             NA         NA         NA       NA    
## ASV5787             NA         NA         NA       NA    
## ASV9455             NA         NA         NA       NA    
## ASV10879            NA         NA         NA       NA    
## ASV3997             NA         NA         NA       NA    
## ASV6760             NA         NA         NA       NA    
## ASV6990             NA         NA         NA       NA    
## ASV9560             NA         NA         NA       NA    
## ASV0220             NA         NA         NA       NA    
## ASV2518             NA         NA         NA       NA    
## ASV3615             NA         NA         NA       NA    
## ASV0075             NA         NA         NA       NA    
## ASV8070             NA         NA         NA       NA    
## ASV1658             NA         NA         NA       NA    
## ASV0773             NA         NA         NA       NA    
## ASV0799             NA         NA         NA       NA    
## ASV1839             NA         NA         NA       NA    
## ASV0265             NA         NA         NA       NA    
## ASV3741             NA         NA         NA       NA    
## ASV0847      5.919e+33  1.280e+37  0.000e+00    1.000    
## ASV1026             NA         NA         NA       NA    
## ASV1222             NA         NA         NA       NA    
## ASV0729             NA         NA         NA       NA    
## ASV0143             NA         NA         NA       NA    
## ASV1328             NA         NA         NA       NA    
## ASV9078             NA         NA         NA       NA    
## ASV0027             NA         NA         NA       NA    
## ASV0546             NA         NA         NA       NA    
## ASV1136             NA         NA         NA       NA    
## ASV3081             NA         NA         NA       NA    
## ASV0531             NA         NA         NA       NA    
## ASV2525             NA         NA         NA       NA    
## ASV1083             NA         NA         NA       NA    
## ASV0424             NA         NA         NA       NA    
## ASV0644             NA         NA         NA       NA    
## ASV6007             NA         NA         NA       NA    
## ASV0564             NA         NA         NA       NA    
## ASV1938             NA         NA         NA       NA    
## ASV6516             NA         NA         NA       NA    
## ASV0503             NA         NA         NA       NA    
## ASV6913             NA         NA         NA       NA    
## ASV0164             NA         NA         NA       NA    
## ASV1576             NA         NA         NA       NA    
## ASV1725             NA         NA         NA       NA    
## ASV4501             NA         NA         NA       NA    
## ASV10678            NA         NA         NA       NA    
## ASV0944             NA         NA         NA       NA    
## ASV2292             NA         NA         NA       NA    
## ASV1090             NA         NA         NA       NA    
## ASV9117             NA         NA         NA       NA    
## ASV0285             NA         NA         NA       NA    
## ASV0463             NA         NA         NA       NA    
## ASV3199             NA         NA         NA       NA    
## ASV0150             NA         NA         NA       NA    
## ASV6583             NA         NA         NA       NA    
## ASV0392             NA         NA         NA       NA    
## ASV14007            NA         NA         NA       NA    
## ASV0177             NA         NA         NA       NA    
## ASV6448             NA         NA         NA       NA    
## ASV5399             NA         NA         NA       NA    
## ASV0277             NA         NA         NA       NA    
## ASV2599             NA         NA         NA       NA    
## ASV13465            NA         NA         NA       NA    
## ASV2412             NA         NA         NA       NA    
## ASV0423             NA         NA         NA       NA    
## ASV5187             NA         NA         NA       NA    
## ASV0701             NA         NA         NA       NA    
## ASV4248             NA         NA         NA       NA    
## ASV0519             NA         NA         NA       NA    
## ASV0764             NA         NA         NA       NA    
## ASV5385             NA         NA         NA       NA    
## ASV3021             NA         NA         NA       NA    
## ASV4119             NA         NA         NA       NA    
## ASV2534             NA         NA         NA       NA    
## ASV1061             NA         NA         NA       NA    
## ASV0670             NA         NA         NA       NA    
## ASV1384             NA         NA         NA       NA    
## ASV1981             NA         NA         NA       NA    
## ASV9632             NA         NA         NA       NA    
## ASV4564             NA         NA         NA       NA    
## ASV5289             NA         NA         NA       NA    
## ASV0516             NA         NA         NA       NA    
## ASV1463             NA         NA         NA       NA    
## ASV0969             NA         NA         NA       NA    
## ASV1113             NA         NA         NA       NA    
## ASV1234             NA         NA         NA       NA    
## ASV3814             NA         NA         NA       NA    
## ASV1000     -6.810e+33  1.279e+37 -1.000e-03    1.000    
## ASV0079             NA         NA         NA       NA    
## ASV0145     -9.941e+32  3.969e+36  0.000e+00    1.000    
## ASV0457             NA         NA         NA       NA    
## ASV1485             NA         NA         NA       NA    
## ASV0535             NA         NA         NA       NA    
## ASV0259             NA         NA         NA       NA    
## ASV0570             NA         NA         NA       NA    
## ASV0906             NA         NA         NA       NA    
## ASV1748             NA         NA         NA       NA    
## ASV5520             NA         NA         NA       NA    
## ASV2288             NA         NA         NA       NA    
## ASV1887             NA         NA         NA       NA    
## ASV0374             NA         NA         NA       NA    
## ASV0823             NA         NA         NA       NA    
## ASV0717             NA         NA         NA       NA    
## ASV0431             NA         NA         NA       NA    
## ASV1030             NA         NA         NA       NA    
## ASV1082             NA         NA         NA       NA    
## ASV2684             NA         NA         NA       NA    
## ASV0051             NA         NA         NA       NA    
## ASV0513             NA         NA         NA       NA    
## ASV0581             NA         NA         NA       NA    
## ASV7282             NA         NA         NA       NA    
## ASV3009             NA         NA         NA       NA    
## ASV2106             NA         NA         NA       NA    
## ASV1012             NA         NA         NA       NA    
## ASV0921             NA         NA         NA       NA    
## ASV0010             NA         NA         NA       NA    
## ASV1178             NA         NA         NA       NA    
## ASV2848             NA         NA         NA       NA    
## ASV0586      4.507e+33  4.181e+36  1.000e-03    0.999    
## ASV4225             NA         NA         NA       NA    
## ASV2156             NA         NA         NA       NA    
## ASV9778             NA         NA         NA       NA    
## ASV0493             NA         NA         NA       NA    
## ASV3770             NA         NA         NA       NA    
## ASV0470             NA         NA         NA       NA    
## ASV0262             NA         NA         NA       NA    
## ASV0998             NA         NA         NA       NA    
## ASV7708             NA         NA         NA       NA    
## ASV0453             NA         NA         NA       NA    
## ASV0044             NA         NA         NA       NA    
## ASV5490             NA         NA         NA       NA    
## ASV2638             NA         NA         NA       NA    
## ASV0829             NA         NA         NA       NA    
## ASV0601             NA         NA         NA       NA    
## ASV0234             NA         NA         NA       NA    
## ASV0133             NA         NA         NA       NA    
## ASV0323             NA         NA         NA       NA    
## ASV0854             NA         NA         NA       NA    
## ASV0110             NA         NA         NA       NA    
## ASV0816             NA         NA         NA       NA    
## ASV1031             NA         NA         NA       NA    
## ASV0144      6.521e+32  5.367e+35  1.000e-03    0.999    
## ASV0020             NA         NA         NA       NA    
## ASV0962             NA         NA         NA       NA    
## ASV0794             NA         NA         NA       NA    
## ASV7117             NA         NA         NA       NA    
## ASV1008             NA         NA         NA       NA    
## ASV0096             NA         NA         NA       NA    
## ASV0128             NA         NA         NA       NA    
## ASV5232             NA         NA         NA       NA    
## ASV0031             NA         NA         NA       NA    
## ASV1744             NA         NA         NA       NA    
## ASV0289     -1.078e+33  4.590e+36  0.000e+00    1.000    
## ASV7413             NA         NA         NA       NA    
## ASV0822             NA         NA         NA       NA    
## ASV8111             NA         NA         NA       NA    
## ASV0687             NA         NA         NA       NA    
## ASV0112             NA         NA         NA       NA    
## ASV0987             NA         NA         NA       NA    
## ASV5332             NA         NA         NA       NA    
## ASV1129             NA         NA         NA       NA    
## ASV1274             NA         NA         NA       NA    
## ASV0119             NA         NA         NA       NA    
## ASV0890             NA         NA         NA       NA    
## ASV0848     -3.263e+33  6.580e+36  0.000e+00    1.000    
## ASV5944             NA         NA         NA       NA    
## ASV19741            NA         NA         NA       NA    
## ASV0504             NA         NA         NA       NA    
## ASV2146             NA         NA         NA       NA    
## ASV0089             NA         NA         NA       NA    
## ASV2301             NA         NA         NA       NA    
## ASV2982             NA         NA         NA       NA    
## ASV0891             NA         NA         NA       NA    
## ASV0093             NA         NA         NA       NA    
## ASV0042             NA         NA         NA       NA    
## ASV0980             NA         NA         NA       NA    
## ASV0069             NA         NA         NA       NA    
## ASV1364             NA         NA         NA       NA    
## ASV0524             NA         NA         NA       NA    
## ASV0435             NA         NA         NA       NA    
## ASV0517             NA         NA         NA       NA    
## ASV3167             NA         NA         NA       NA    
## ASV4280             NA         NA         NA       NA    
## ASV1158             NA         NA         NA       NA    
## ASV2214             NA         NA         NA       NA    
## ASV0544             NA         NA         NA       NA    
## ASV5326             NA         NA         NA       NA    
## ASV3765             NA         NA         NA       NA    
## ASV4646             NA         NA         NA       NA    
## ASV0090             NA         NA         NA       NA    
## ASV3680             NA         NA         NA       NA    
## ASV0111      1.611e+33  6.472e+36  0.000e+00    1.000    
## ASV0768             NA         NA         NA       NA    
## ASV4862             NA         NA         NA       NA    
## ASV1742             NA         NA         NA       NA    
## ASV3701             NA         NA         NA       NA    
## ASV2386             NA         NA         NA       NA    
## ASV0375             NA         NA         NA       NA    
## ASV2796             NA         NA         NA       NA    
## ASV1369             NA         NA         NA       NA    
## ASV10272            NA         NA         NA       NA    
## ASV10354            NA         NA         NA       NA    
## ASV1067             NA         NA         NA       NA    
## ASV1900             NA         NA         NA       NA    
## ASV4079             NA         NA         NA       NA    
## ASV4149             NA         NA         NA       NA    
## ASV5140             NA         NA         NA       NA    
## ASV10782            NA         NA         NA       NA    
## ASV4273             NA         NA         NA       NA    
## ASV8121             NA         NA         NA       NA    
## ASV8438             NA         NA         NA       NA    
## ASV9390             NA         NA         NA       NA    
## ASV1340             NA         NA         NA       NA    
## ASV2650             NA         NA         NA       NA    
## ASV4674             NA         NA         NA       NA    
## ASV10492            NA         NA         NA       NA    
## ASV11430            NA         NA         NA       NA    
## ASV12135            NA         NA         NA       NA    
## ASV14970            NA         NA         NA       NA    
## ASV1954             NA         NA         NA       NA    
## ASV2613             NA         NA         NA       NA    
## ASV2757             NA         NA         NA       NA    
## ASV2909             NA         NA         NA       NA    
## ASV2954             NA         NA         NA       NA    
## ASV2969             NA         NA         NA       NA    
## ASV3410             NA         NA         NA       NA    
## ASV3575             NA         NA         NA       NA    
## ASV4275             NA         NA         NA       NA    
## ASV4652             NA         NA         NA       NA    
## ASV4761             NA         NA         NA       NA    
## ASV6003             NA         NA         NA       NA    
## ASV6110             NA         NA         NA       NA    
## ASV7427             NA         NA         NA       NA    
## ASV8092             NA         NA         NA       NA    
## ASV8169             NA         NA         NA       NA    
## ASV9693             NA         NA         NA       NA    
## ASV10913            NA         NA         NA       NA    
## ASV1979             NA         NA         NA       NA    
## ASV3772             NA         NA         NA       NA    
## ASV0113             NA         NA         NA       NA    
## ASV1800     -7.688e+32  1.585e+36  0.000e+00    1.000    
## ASV2335             NA         NA         NA       NA    
## ASV0692             NA         NA         NA       NA    
## ASV1120             NA         NA         NA       NA    
## ASV1434             NA         NA         NA       NA    
## ASV0076             NA         NA         NA       NA    
## ASV0361             NA         NA         NA       NA    
## ASV2231     -8.934e+32  5.177e+36  0.000e+00    1.000    
## ASV2018             NA         NA         NA       NA    
## ASV1529             NA         NA         NA       NA    
## ASV0841             NA         NA         NA       NA    
## ASV2556             NA         NA         NA       NA    
## ASV2777             NA         NA         NA       NA    
## ASV0355             NA         NA         NA       NA    
## ASV5169             NA         NA         NA       NA    
## ASV3091             NA         NA         NA       NA    
## ASV2435             NA         NA         NA       NA    
## ASV6822             NA         NA         NA       NA    
## ASV12605            NA         NA         NA       NA    
## ASV0286             NA         NA         NA       NA    
## ASV0074             NA         NA         NA       NA    
## ASV2485             NA         NA         NA       NA    
## ASV1233             NA         NA         NA       NA    
## ASV0356             NA         NA         NA       NA    
## ASV2918             NA         NA         NA       NA    
## ASV1427             NA         NA         NA       NA    
## ASV1409             NA         NA         NA       NA    
## ASV0770             NA         NA         NA       NA    
## ASV1403             NA         NA         NA       NA    
## ASV0314             NA         NA         NA       NA    
## ASV0187             NA         NA         NA       NA    
## ASV0313             NA         NA         NA       NA    
## ASV1087             NA         NA         NA       NA    
## ASV1970             NA         NA         NA       NA    
## ASV0754             NA         NA         NA       NA    
## ASV3775             NA         NA         NA       NA    
## ASV0132             NA         NA         NA       NA    
## ASV2329             NA         NA         NA       NA    
## ASV0561             NA         NA         NA       NA    
## ASV0130             NA         NA         NA       NA    
## ASV0226             NA         NA         NA       NA    
## ASV12648            NA         NA         NA       NA    
## ASV0204     -2.008e+33  8.502e+36  0.000e+00    1.000    
## ASV0767             NA         NA         NA       NA    
## ASV0335             NA         NA         NA       NA    
## ASV5901     -6.731e+33  2.253e+37  0.000e+00    1.000    
## ASV0596             NA         NA         NA       NA    
## ASV9271             NA         NA         NA       NA    
## ASV0904             NA         NA         NA       NA    
## ASV15270            NA         NA         NA       NA    
## ASV0990             NA         NA         NA       NA    
## ASV0155             NA         NA         NA       NA    
## ASV0086             NA         NA         NA       NA    
## ASV2581     -1.695e+32  3.090e+36  0.000e+00    1.000    
## ASV1579             NA         NA         NA       NA    
## ASV7730             NA         NA         NA       NA    
## ASV0897             NA         NA         NA       NA    
## ASV1975             NA         NA         NA       NA    
## ASV0759             NA         NA         NA       NA    
## ASV3082             NA         NA         NA       NA    
## ASV3195             NA         NA         NA       NA    
## ASV0427             NA         NA         NA       NA    
## ASV2674             NA         NA         NA       NA    
## ASV1500             NA         NA         NA       NA    
## ASV0102     -3.954e+33  2.600e+37  0.000e+00    1.000    
## ASV1217             NA         NA         NA       NA    
## ASV4998             NA         NA         NA       NA    
## ASV2890             NA         NA         NA       NA    
## ASV0672     -2.250e+33  3.765e+36 -1.000e-03    1.000    
## ASV6960             NA         NA         NA       NA    
## ASV0821             NA         NA         NA       NA    
## ASV1995             NA         NA         NA       NA    
## ASV0211             NA         NA         NA       NA    
## ASV0364             NA         NA         NA       NA    
## ASV3616             NA         NA         NA       NA    
## ASV1996             NA         NA         NA       NA    
## ASV1881             NA         NA         NA       NA    
## ASV1089             NA         NA         NA       NA    
## ASV1450             NA         NA         NA       NA    
## ASV4643             NA         NA         NA       NA    
## ASV3458             NA         NA         NA       NA    
## ASV2543             NA         NA         NA       NA    
## ASV3306             NA         NA         NA       NA    
## ASV0218             NA         NA         NA       NA    
## ASV3727             NA         NA         NA       NA    
## ASV4394             NA         NA         NA       NA    
## ASV2636             NA         NA         NA       NA    
## ASV5116             NA         NA         NA       NA    
## ASV1394             NA         NA         NA       NA    
## ASV0656             NA         NA         NA       NA    
## ASV0475             NA         NA         NA       NA    
## ASV1042             NA         NA         NA       NA    
## ASV1199             NA         NA         NA       NA    
## ASV12962            NA         NA         NA       NA    
## ASV0853             NA         NA         NA       NA    
## ASV5069             NA         NA         NA       NA    
## ASV7825             NA         NA         NA       NA    
## ASV0339             NA         NA         NA       NA    
## ASV2965             NA         NA         NA       NA    
## ASV2347             NA         NA         NA       NA    
## ASV0541             NA         NA         NA       NA    
## ASV0369     -2.789e+33  1.253e+36 -2.000e-03    0.998    
## ASV0171             NA         NA         NA       NA    
## ASV2235             NA         NA         NA       NA    
## ASV5809             NA         NA         NA       NA    
## ASV1267             NA         NA         NA       NA    
## ASV0207             NA         NA         NA       NA    
## ASV3126             NA         NA         NA       NA    
## ASV0183             NA         NA         NA       NA    
## ASV1792             NA         NA         NA       NA    
## ASV2001             NA         NA         NA       NA    
## ASV5732             NA         NA         NA       NA    
## ASV2857             NA         NA         NA       NA    
## ASV1052             NA         NA         NA       NA    
## ASV3226             NA         NA         NA       NA    
## ASV3766             NA         NA         NA       NA    
## ASV0982             NA         NA         NA       NA    
## ASV0489             NA         NA         NA       NA    
## ASV3990             NA         NA         NA       NA    
## ASV0433             NA         NA         NA       NA    
## ASV0684             NA         NA         NA       NA    
## ASV0063     -5.928e+32  2.858e+36  0.000e+00    1.000    
## ASV1399             NA         NA         NA       NA    
## ASV3093             NA         NA         NA       NA    
## ASV1771             NA         NA         NA       NA    
## ASV7910             NA         NA         NA       NA    
## ASV3718             NA         NA         NA       NA    
## ASV0039             NA         NA         NA       NA    
## ASV6469             NA         NA         NA       NA    
## ASV8186             NA         NA         NA       NA    
## ASV1091             NA         NA         NA       NA    
## ASV16930            NA         NA         NA       NA    
## ASV7234             NA         NA         NA       NA    
## ASV1560             NA         NA         NA       NA    
## ASV2968             NA         NA         NA       NA    
## ASV3824             NA         NA         NA       NA    
## ASV0442             NA         NA         NA       NA    
## ASV0677             NA         NA         NA       NA    
## ASV4796             NA         NA         NA       NA    
## ASV2206             NA         NA         NA       NA    
## ASV2884             NA         NA         NA       NA    
## ASV0482             NA         NA         NA       NA    
## ASV1273             NA         NA         NA       NA    
## ASV1910             NA         NA         NA       NA    
## ASV0105             NA         NA         NA       NA    
## ASV0149             NA         NA         NA       NA    
## ASV5007             NA         NA         NA       NA    
## ASV0757             NA         NA         NA       NA    
## ASV11952            NA         NA         NA       NA    
## ASV4102      2.853e+33  7.504e+36  0.000e+00    1.000    
## ASV1034             NA         NA         NA       NA    
## ASV0753             NA         NA         NA       NA    
## ASV2323             NA         NA         NA       NA    
## ASV0881             NA         NA         NA       NA    
## ASV3730             NA         NA         NA       NA    
## ASV2685             NA         NA         NA       NA    
## ASV3826             NA         NA         NA       NA    
## ASV0689             NA         NA         NA       NA    
## ASV4315             NA         NA         NA       NA    
## ASV1239             NA         NA         NA       NA    
## ASV3147             NA         NA         NA       NA    
## ASV3454             NA         NA         NA       NA    
## ASV4411             NA         NA         NA       NA    
## ASV3007             NA         NA         NA       NA    
## ASV6151             NA         NA         NA       NA    
## ASV0834             NA         NA         NA       NA    
## ASV1231             NA         NA         NA       NA    
## ASV0643             NA         NA         NA       NA    
## ASV0924             NA         NA         NA       NA    
## ASV3238             NA         NA         NA       NA    
## ASV1276             NA         NA         NA       NA    
## ASV5503             NA         NA         NA       NA    
## ASV0404             NA         NA         NA       NA    
## ASV3430             NA         NA         NA       NA    
## ASV5401             NA         NA         NA       NA    
## ASV3426     -1.044e+33  1.557e+36 -1.000e-03    0.999    
## ASV0777             NA         NA         NA       NA    
## ASV11093            NA         NA         NA       NA    
## ASV2170             NA         NA         NA       NA    
## ASV3861             NA         NA         NA       NA    
## ASV1723             NA         NA         NA       NA    
## ASV2460             NA         NA         NA       NA    
## ASV1218             NA         NA         NA       NA    
## ASV0436             NA         NA         NA       NA    
## ASV0919             NA         NA         NA       NA    
## ASV0577             NA         NA         NA       NA    
## ASV2517             NA         NA         NA       NA    
## ASV2628             NA         NA         NA       NA    
## ASV1743             NA         NA         NA       NA    
## ASV1678             NA         NA         NA       NA    
## ASV0315             NA         NA         NA       NA    
## ASV0253             NA         NA         NA       NA    
## ASV1363             NA         NA         NA       NA    
## ASV0995             NA         NA         NA       NA    
## ASV4185             NA         NA         NA       NA    
## ASV0782             NA         NA         NA       NA    
## ASV3240             NA         NA         NA       NA    
## ASV1392             NA         NA         NA       NA    
## ASV8488             NA         NA         NA       NA    
## ASV2814             NA         NA         NA       NA    
## ASV0678             NA         NA         NA       NA    
## ASV1295             NA         NA         NA       NA    
## ASV7517             NA         NA         NA       NA    
## ASV2996             NA         NA         NA       NA    
## ASV2882             NA         NA         NA       NA    
## ASV1317             NA         NA         NA       NA    
## ASV9106             NA         NA         NA       NA    
## ASV9688             NA         NA         NA       NA    
## ASV6181             NA         NA         NA       NA    
## ASV2936      1.559e+33  2.228e+36  1.000e-03    0.999    
## ASV0192             NA         NA         NA       NA    
## ASV2509             NA         NA         NA       NA    
## ASV0863             NA         NA         NA       NA    
## ASV2762             NA         NA         NA       NA    
## ASV4904             NA         NA         NA       NA    
## ASV0571             NA         NA         NA       NA    
## ASV13304            NA         NA         NA       NA    
## ASV6863             NA         NA         NA       NA    
## ASV4844             NA         NA         NA       NA    
## ASV10779            NA         NA         NA       NA    
## ASV7921             NA         NA         NA       NA    
## ASV8458             NA         NA         NA       NA    
## ASV2593             NA         NA         NA       NA    
## ASV4410             NA         NA         NA       NA    
## ASV0593             NA         NA         NA       NA    
## ASV2669             NA         NA         NA       NA    
## ASV0868             NA         NA         NA       NA    
## ASV3123             NA         NA         NA       NA    
## ASV3482             NA         NA         NA       NA    
## ASV2552             NA         NA         NA       NA    
## ASV0723             NA         NA         NA       NA    
## ASV0526             NA         NA         NA       NA    
## ASV4623             NA         NA         NA       NA    
## ASV2070             NA         NA         NA       NA    
## ASV1198             NA         NA         NA       NA    
## ASV3034             NA         NA         NA       NA    
## ASV1208             NA         NA         NA       NA    
## ASV4860             NA         NA         NA       NA    
## ASV2493             NA         NA         NA       NA    
## ASV4217             NA         NA         NA       NA    
## ASV1516             NA         NA         NA       NA    
## ASV1186             NA         NA         NA       NA    
## ASV1906             NA         NA         NA       NA    
## ASV8220             NA         NA         NA       NA    
## ASV4227             NA         NA         NA       NA    
## ASV1013             NA         NA         NA       NA    
## ASV7952             NA         NA         NA       NA    
## ASV5923             NA         NA         NA       NA    
## ASV0190             NA         NA         NA       NA    
## ASV0491     -5.012e+32  1.469e+36  0.000e+00    1.000    
## ASV9535             NA         NA         NA       NA    
## ASV9947             NA         NA         NA       NA    
## ASV6518             NA         NA         NA       NA    
## ASV1741             NA         NA         NA       NA    
## ASV1874             NA         NA         NA       NA    
## ASV2150             NA         NA         NA       NA    
## ASV5262             NA         NA         NA       NA    
## ASV1729             NA         NA         NA       NA    
## ASV1522             NA         NA         NA       NA    
## ASV3250             NA         NA         NA       NA    
## ASV4338             NA         NA         NA       NA    
## ASV1386             NA         NA         NA       NA    
## ASV0694             NA         NA         NA       NA    
## ASV2026             NA         NA         NA       NA    
## ASV0191             NA         NA         NA       NA    
## ASV1641             NA         NA         NA       NA    
## ASV1326             NA         NA         NA       NA    
## ASV4786             NA         NA         NA       NA    
## ASV0342             NA         NA         NA       NA    
## ASV3025             NA         NA         NA       NA    
## ASV6533             NA         NA         NA       NA    
## ASV1898             NA         NA         NA       NA    
## ASV1940             NA         NA         NA       NA    
## ASV4968             NA         NA         NA       NA    
## ASV3401             NA         NA         NA       NA    
## ASV3211             NA         NA         NA       NA    
## ASV1489             NA         NA         NA       NA    
## ASV4139             NA         NA         NA       NA    
## ASV6059             NA         NA         NA       NA    
## ASV0918             NA         NA         NA       NA    
## ASV1449      1.445e+33  2.907e+36  0.000e+00    1.000    
## ASV5652             NA         NA         NA       NA    
## ASV4091             NA         NA         NA       NA    
## ASV7638             NA         NA         NA       NA    
## ASV6525             NA         NA         NA       NA    
## ASV8959             NA         NA         NA       NA    
## ASV0699             NA         NA         NA       NA    
## ASV2925             NA         NA         NA       NA    
## ASV0618             NA         NA         NA       NA    
## ASV2083      2.631e+33  7.032e+36  0.000e+00    1.000    
## ASV6192             NA         NA         NA       NA    
## ASV8640             NA         NA         NA       NA    
## ASV1103             NA         NA         NA       NA    
## ASV4240             NA         NA         NA       NA    
## ASV2180             NA         NA         NA       NA    
## ASV9157             NA         NA         NA       NA    
## ASV1307             NA         NA         NA       NA    
## ASV4960             NA         NA         NA       NA    
## ASV3930             NA         NA         NA       NA    
## ASV1200             NA         NA         NA       NA    
## ASV4676             NA         NA         NA       NA    
## ASV6993             NA         NA         NA       NA    
## ASV4813             NA         NA         NA       NA    
## ASV4364             NA         NA         NA       NA    
## ASV0141             NA         NA         NA       NA    
## ASV3509             NA         NA         NA       NA    
## ASV2751             NA         NA         NA       NA    
## ASV4913             NA         NA         NA       NA    
## ASV0138             NA         NA         NA       NA    
## ASV7697             NA         NA         NA       NA    
## ASV1602             NA         NA         NA       NA    
## ASV5976             NA         NA         NA       NA    
## ASV7525             NA         NA         NA       NA    
## ASV4961             NA         NA         NA       NA    
## ASV2546             NA         NA         NA       NA    
## ASV0721             NA         NA         NA       NA    
## ASV0542             NA         NA         NA       NA    
## ASV3865             NA         NA         NA       NA    
## ASV5571             NA         NA         NA       NA    
## ASV6804             NA         NA         NA       NA    
## ASV4424             NA         NA         NA       NA    
## ASV3395             NA         NA         NA       NA    
## ASV2394             NA         NA         NA       NA    
## ASV8629             NA         NA         NA       NA    
## ASV1018             NA         NA         NA       NA    
## ASV6139             NA         NA         NA       NA    
## ASV10411            NA         NA         NA       NA    
## ASV3992             NA         NA         NA       NA    
## ASV7131             NA         NA         NA       NA    
## ASV3729      2.053e+33  5.986e+36  0.000e+00    1.000    
## ASV2197             NA         NA         NA       NA    
## ASV2426             NA         NA         NA       NA    
## ASV3669             NA         NA         NA       NA    
## ASV1820             NA         NA         NA       NA    
## ASV7081             NA         NA         NA       NA    
## ASV7872             NA         NA         NA       NA    
## ASV1670             NA         NA         NA       NA    
## ASV0712             NA         NA         NA       NA    
## ASV0474             NA         NA         NA       NA    
## ASV1196             NA         NA         NA       NA    
## ASV0845             NA         NA         NA       NA    
## ASV12393            NA         NA         NA       NA    
## ASV5867             NA         NA         NA       NA    
## ASV17619            NA         NA         NA       NA    
## ASV4686             NA         NA         NA       NA    
## ASV3520             NA         NA         NA       NA    
## ASV10800            NA         NA         NA       NA    
## ASV2706             NA         NA         NA       NA    
## ASV1227             NA         NA         NA       NA    
## ASV2621             NA         NA         NA       NA    
## ASV0460             NA         NA         NA       NA    
## ASV1069             NA         NA         NA       NA    
## ASV6939             NA         NA         NA       NA    
## ASV2862             NA         NA         NA       NA    
## ASV1021             NA         NA         NA       NA    
## ASV3845             NA         NA         NA       NA    
## ASV0732             NA         NA         NA       NA    
## ASV10731            NA         NA         NA       NA    
## ASV3378             NA         NA         NA       NA    
## ASV7154             NA         NA         NA       NA    
## ASV9876             NA         NA         NA       NA    
## ASV0631             NA         NA         NA       NA    
## ASV13027            NA         NA         NA       NA    
## ASV2497             NA         NA         NA       NA    
## ASV3966             NA         NA         NA       NA    
## ASV2574             NA         NA         NA       NA    
## ASV0545             NA         NA         NA       NA    
## ASV8453             NA         NA         NA       NA    
## ASV0221             NA         NA         NA       NA    
## ASV3305             NA         NA         NA       NA    
## ASV2647             NA         NA         NA       NA    
## ASV5789             NA         NA         NA       NA    
## ASV1731             NA         NA         NA       NA    
## ASV3857             NA         NA         NA       NA    
## ASV0405             NA         NA         NA       NA    
## ASV0094             NA         NA         NA       NA    
## ASV0158             NA         NA         NA       NA    
## ASV5507             NA         NA         NA       NA    
## ASV1023             NA         NA         NA       NA    
## ASV0488             NA         NA         NA       NA    
## ASV1459             NA         NA         NA       NA    
## ASV4349             NA         NA         NA       NA    
## ASV1172             NA         NA         NA       NA    
## ASV10187            NA         NA         NA       NA    
## ASV7227             NA         NA         NA       NA    
## ASV10340            NA         NA         NA       NA    
## ASV10821            NA         NA         NA       NA    
## ASV13810            NA         NA         NA       NA    
## ASV3230             NA         NA         NA       NA    
## ASV5524             NA         NA         NA       NA    
## ASV8742             NA         NA         NA       NA    
## ASV9188             NA         NA         NA       NA    
## ASV4658             NA         NA         NA       NA    
## ASV7889             NA         NA         NA       NA    
## ASV1466             NA         NA         NA       NA    
## ASV1424             NA         NA         NA       NA    
## ASV0098             NA         NA         NA       NA    
## ASV0067             NA         NA         NA       NA    
## ASV9434             NA         NA         NA       NA    
## ASV3270             NA         NA         NA       NA    
## ASV4518             NA         NA         NA       NA    
## ASV7661             NA         NA         NA       NA    
## ASV4223             NA         NA         NA       NA    
## ASV3481             NA         NA         NA       NA    
## ASV7819             NA         NA         NA       NA    
## ASV3095             NA         NA         NA       NA    
## ASV4476             NA         NA         NA       NA    
## ASV1713             NA         NA         NA       NA    
## ASV11165            NA         NA         NA       NA    
## ASV2179             NA         NA         NA       NA    
## ASV3747      3.623e+32  7.290e+36  0.000e+00    1.000    
## ASV1410             NA         NA         NA       NA    
## ASV6069             NA         NA         NA       NA    
## ASV1939             NA         NA         NA       NA    
## ASV7865             NA         NA         NA       NA    
## ASV4488             NA         NA         NA       NA    
## ASV0938             NA         NA         NA       NA    
## ASV7852             NA         NA         NA       NA    
## ASV2503             NA         NA         NA       NA    
## ASV2993             NA         NA         NA       NA    
## ASV3752             NA         NA         NA       NA    
## ASV2557             NA         NA         NA       NA    
## ASV6522             NA         NA         NA       NA    
## ASV0088             NA         NA         NA       NA    
## ASV7935             NA         NA         NA       NA    
## ASV0942             NA         NA         NA       NA    
## ASV7709             NA         NA         NA       NA    
## ASV4588             NA         NA         NA       NA    
## ASV5765             NA         NA         NA       NA    
## ASV3562             NA         NA         NA       NA    
## ASV9076             NA         NA         NA       NA    
## ASV4707             NA         NA         NA       NA    
## ASV2188             NA         NA         NA       NA    
## ASV0613             NA         NA         NA       NA    
## ASV0663             NA         NA         NA       NA    
## ASV3361             NA         NA         NA       NA    
## ASV1478             NA         NA         NA       NA    
## ASV0213             NA         NA         NA       NA    
## ASV7674             NA         NA         NA       NA    
## ASV2137     -3.418e+32  6.469e+35 -1.000e-03    1.000    
## ASV8246             NA         NA         NA       NA    
## ASV0047             NA         NA         NA       NA    
## ASV6117             NA         NA         NA       NA    
## ASV3349             NA         NA         NA       NA    
## ASV10881            NA         NA         NA       NA    
## ASV6979             NA         NA         NA       NA    
## ASV7930             NA         NA         NA       NA    
## ASV7322             NA         NA         NA       NA    
## ASV4927             NA         NA         NA       NA    
## ASV9054             NA         NA         NA       NA    
## ASV2692             NA         NA         NA       NA    
## ASV1666             NA         NA         NA       NA    
## ASV4728             NA         NA         NA       NA    
## ASV3097             NA         NA         NA       NA    
## ASV4962             NA         NA         NA       NA    
## ASV5057             NA         NA         NA       NA    
## ASV2639             NA         NA         NA       NA    
## ASV1808             NA         NA         NA       NA    
## ASV6333             NA         NA         NA       NA    
## ASV4328             NA         NA         NA       NA    
## ASV7707             NA         NA         NA       NA    
## ASV11022            NA         NA         NA       NA    
## ASV1469             NA         NA         NA       NA    
## ASV3919             NA         NA         NA       NA    
## ASV4038             NA         NA         NA       NA    
## ASV4048             NA         NA         NA       NA    
## ASV0634             NA         NA         NA       NA    
## ASV1852             NA         NA         NA       NA    
## ASV2505             NA         NA         NA       NA    
## ASV1762             NA         NA         NA       NA    
## ASV3761             NA         NA         NA       NA    
## ASV0775             NA         NA         NA       NA    
## ASV10911            NA         NA         NA       NA    
## ASV1339             NA         NA         NA       NA    
## ASV5214             NA         NA         NA       NA    
## ASV4945             NA         NA         NA       NA    
## ASV5624             NA         NA         NA       NA    
## ASV3429             NA         NA         NA       NA    
## ASV8416             NA         NA         NA       NA    
## ASV2400             NA         NA         NA       NA    
## ASV3388             NA         NA         NA       NA    
## ASV7089             NA         NA         NA       NA    
## ASV3396             NA         NA         NA       NA    
## ASV0343             NA         NA         NA       NA    
## ASV5505             NA         NA         NA       NA    
## ASV6721             NA         NA         NA       NA    
## ASV0537     -6.942e+32  1.508e+36  0.000e+00    1.000    
## ASV7753             NA         NA         NA       NA    
## ASV5022             NA         NA         NA       NA    
## ASV1073             NA         NA         NA       NA    
## ASV1347             NA         NA         NA       NA    
## ASV15032            NA         NA         NA       NA    
## ASV18213            NA         NA         NA       NA    
## ASV20691            NA         NA         NA       NA    
## ASV4260             NA         NA         NA       NA    
## ASV4923             NA         NA         NA       NA    
## ASV7995             NA         NA         NA       NA    
## ASV8960             NA         NA         NA       NA    
## ASV10682            NA         NA         NA       NA    
## ASV11911            NA         NA         NA       NA    
## ASV14296            NA         NA         NA       NA    
## ASV2314             NA         NA         NA       NA    
## ASV3819             NA         NA         NA       NA    
## ASV4517             NA         NA         NA       NA    
## ASV8941             NA         NA         NA       NA    
## ASV1444             NA         NA         NA       NA    
## ASV5959             NA         NA         NA       NA    
## ASV3623             NA         NA         NA       NA    
## ASV0260             NA         NA         NA       NA    
## ASV4401             NA         NA         NA       NA    
## ASV2891             NA         NA         NA       NA    
## ASV2778             NA         NA         NA       NA    
## ASV8744             NA         NA         NA       NA    
## ASV1079             NA         NA         NA       NA    
## ASV19688            NA         NA         NA       NA    
## ASV4039      8.792e+32  1.892e+36  0.000e+00    1.000    
## ASV4982             NA         NA         NA       NA    
## ASV1071             NA         NA         NA       NA    
## ASV7666             NA         NA         NA       NA    
## ASV0502             NA         NA         NA       NA    
## ASV3624             NA         NA         NA       NA    
## ASV0403      1.420e+32  4.705e+36  0.000e+00    1.000    
## ASV4939             NA         NA         NA       NA    
## ASV6297             NA         NA         NA       NA    
## ASV6343             NA         NA         NA       NA    
## ASV0954             NA         NA         NA       NA    
## ASV10225            NA         NA         NA       NA    
## ASV1584             NA         NA         NA       NA    
## ASV1803             NA         NA         NA       NA    
## ASV2576             NA         NA         NA       NA    
## ASV3252             NA         NA         NA       NA    
## ASV3463             NA         NA         NA       NA    
## ASV3822             NA         NA         NA       NA    
## ASV4926             NA         NA         NA       NA    
## ASV5564             NA         NA         NA       NA    
## ASV5595             NA         NA         NA       NA    
## ASV16463            NA         NA         NA       NA    
## ASV6277             NA         NA         NA       NA    
## ASV1344             NA         NA         NA       NA    
## ASV1869             NA         NA         NA       NA    
## ASV8155             NA         NA         NA       NA    
## ASV2502             NA         NA         NA       NA    
## ASV6742             NA         NA         NA       NA    
## ASV3124             NA         NA         NA       NA    
## ASV17042            NA         NA         NA       NA    
## ASV0248             NA         NA         NA       NA    
## ASV4557             NA         NA         NA       NA    
## ASV3507             NA         NA         NA       NA    
## ASV1870             NA         NA         NA       NA    
## ASV2447             NA         NA         NA       NA    
## ASV0347             NA         NA         NA       NA    
## ASV1855             NA         NA         NA       NA    
## ASV0568             NA         NA         NA       NA    
## ASV1620             NA         NA         NA       NA    
## ASV0101             NA         NA         NA       NA    
## ASV7751             NA         NA         NA       NA    
## ASV9033             NA         NA         NA       NA    
## ASV3438             NA         NA         NA       NA    
## ASV0637             NA         NA         NA       NA    
## ASV1181             NA         NA         NA       NA    
## ASV13480            NA         NA         NA       NA    
## ASV14220            NA         NA         NA       NA    
## ASV1448             NA         NA         NA       NA    
## ASV1457             NA         NA         NA       NA    
## ASV1645             NA         NA         NA       NA    
## ASV2300             NA         NA         NA       NA    
## ASV2533             NA         NA         NA       NA    
## ASV5059             NA         NA         NA       NA    
## ASV8871             NA         NA         NA       NA    
## ASV1289             NA         NA         NA       NA    
## ASV3983             NA         NA         NA       NA    
## ASV10323            NA         NA         NA       NA    
## ASV13279            NA         NA         NA       NA    
## ASV7149             NA         NA         NA       NA    
## ASV1691             NA         NA         NA       NA    
## ASV1649             NA         NA         NA       NA    
## ASV10120     1.943e+33  1.290e+36  2.000e-03    0.999    
## ASV8285             NA         NA         NA       NA    
## ASV0037             NA         NA         NA       NA    
## ASV1770             NA         NA         NA       NA    
## ASV2252             NA         NA         NA       NA    
## ASV7580             NA         NA         NA       NA    
## ASV5643             NA         NA         NA       NA    
## ASV2722             NA         NA         NA       NA    
## ASV2662             NA         NA         NA       NA    
## ASV0479             NA         NA         NA       NA    
## ASV2009             NA         NA         NA       NA    
## ASV3731             NA         NA         NA       NA    
## ASV5497             NA         NA         NA       NA    
## ASV6647             NA         NA         NA       NA    
## ASV8974             NA         NA         NA       NA    
## ASV15527            NA         NA         NA       NA    
## ASV6705      3.039e+33  9.068e+36  0.000e+00    1.000    
## ASV0354             NA         NA         NA       NA    
## ASV2707             NA         NA         NA       NA    
## ASV11167            NA         NA         NA       NA    
## ASV6393             NA         NA         NA       NA    
## ASV3808             NA         NA         NA       NA    
## ASV9337             NA         NA         NA       NA    
## ASV5043      3.768e+32  1.984e+36  0.000e+00    1.000    
## ASV4189             NA         NA         NA       NA    
## ASV1304             NA         NA         NA       NA    
## ASV2105             NA         NA         NA       NA    
## ASV2421             NA         NA         NA       NA    
## ASV3170             NA         NA         NA       NA    
## ASV5036             NA         NA         NA       NA    
## ASV2286             NA         NA         NA       NA    
## ASV3363             NA         NA         NA       NA    
## ASV5759             NA         NA         NA       NA    
## ASV5440             NA         NA         NA       NA    
## ASV2050             NA         NA         NA       NA    
## ASV4478             NA         NA         NA       NA    
## ASV5725             NA         NA         NA       NA    
## ASV1600             NA         NA         NA       NA    
## ASV1654             NA         NA         NA       NA    
## ASV3781             NA         NA         NA       NA    
## ASV7144             NA         NA         NA       NA    
## ASV12710            NA         NA         NA       NA    
## ASV3317             NA         NA         NA       NA    
## ASV3249             NA         NA         NA       NA    
## ASV0669             NA         NA         NA       NA    
## ASV0893             NA         NA         NA       NA    
## ASV11060            NA         NA         NA       NA    
## ASV3207             NA         NA         NA       NA    
## ASV3498             NA         NA         NA       NA    
## ASV4358             NA         NA         NA       NA    
## ASV4806             NA         NA         NA       NA    
## ASV4941             NA         NA         NA       NA    
## ASV6998             NA         NA         NA       NA    
## ASV7327             NA         NA         NA       NA    
## ASV5112             NA         NA         NA       NA    
## ASV5345             NA         NA         NA       NA    
## ASV8911             NA         NA         NA       NA    
## ASV5061             NA         NA         NA       NA    
## ASV1968             NA         NA         NA       NA    
## ASV4669             NA         NA         NA       NA    
## ASV6209             NA         NA         NA       NA    
## ASV6938             NA         NA         NA       NA    
## ASV6987             NA         NA         NA       NA    
## ASV7842             NA         NA         NA       NA    
## ASV17950            NA         NA         NA       NA    
## ASV3380             NA         NA         NA       NA    
## ASV13740            NA         NA         NA       NA    
## ASV4313             NA         NA         NA       NA    
## ASV3891             NA         NA         NA       NA    
## ASV3322      1.794e+33  2.673e+36  1.000e-03    0.999    
## ASV1668             NA         NA         NA       NA    
## ASV1739             NA         NA         NA       NA    
## ASV3194             NA         NA         NA       NA    
## ASV0071             NA         NA         NA       NA    
## ASV0695             NA         NA         NA       NA    
## ASV3835             NA         NA         NA       NA    
## ASV1876             NA         NA         NA       NA    
## ASV4892             NA         NA         NA       NA    
## ASV1212             NA         NA         NA       NA    
## ASV2640             NA         NA         NA       NA    
## ASV7236             NA         NA         NA       NA    
## ASV2353             NA         NA         NA       NA    
## ASV0276             NA         NA         NA       NA    
## ASV2262             NA         NA         NA       NA    
## ASV11201            NA         NA         NA       NA    
## ASV0665             NA         NA         NA       NA    
## ASV5238             NA         NA         NA       NA    
## ASV6885             NA         NA         NA       NA    
## ASV1844             NA         NA         NA       NA    
## ASV0379             NA         NA         NA       NA    
## ASV1040             NA         NA         NA       NA    
## ASV7913             NA         NA         NA       NA    
## ASV1197             NA         NA         NA       NA    
## ASV5918             NA         NA         NA       NA    
## ASV8045             NA         NA         NA       NA    
## ASV16458            NA         NA         NA       NA    
## ASV10827            NA         NA         NA       NA    
## ASV3658             NA         NA         NA       NA    
## ASV0073             NA         NA         NA       NA    
## ASV1951             NA         NA         NA       NA    
## ASV7630             NA         NA         NA       NA    
## ASV9449             NA         NA         NA       NA    
## ASV3944     -1.164e+33  5.862e+36  0.000e+00    1.000    
## ASV1520             NA         NA         NA       NA    
## ASV0307             NA         NA         NA       NA    
## ASV12731            NA         NA         NA       NA    
## ASV0282             NA         NA         NA       NA    
## ASV2646             NA         NA         NA       NA    
## ASV3536             NA         NA         NA       NA    
## ASV10089            NA         NA         NA       NA    
## ASV1185             NA         NA         NA       NA    
## ASV1452             NA         NA         NA       NA    
## ASV1700             NA         NA         NA       NA    
## ASV6948             NA         NA         NA       NA    
## ASV0389             NA         NA         NA       NA    
## ASV11884            NA         NA         NA       NA    
## ASV23165            NA         NA         NA       NA    
## ASV2841             NA         NA         NA       NA    
## ASV2949             NA         NA         NA       NA    
## ASV4037             NA         NA         NA       NA    
## ASV4477             NA         NA         NA       NA    
## ASV4496             NA         NA         NA       NA    
## ASV5784             NA         NA         NA       NA    
## ASV6035             NA         NA         NA       NA    
## ASV6232             NA         NA         NA       NA    
## ASV1818             NA         NA         NA       NA    
## ASV2595             NA         NA         NA       NA    
## ASV2788             NA         NA         NA       NA    
## ASV5018             NA         NA         NA       NA    
## ASV0127             NA         NA         NA       NA    
## ASV1527             NA         NA         NA       NA    
## ASV1055             NA         NA         NA       NA    
## ASV4791             NA         NA         NA       NA    
## ASV0859             NA         NA         NA       NA    
## ASV12971            NA         NA         NA       NA    
## ASV16856            NA         NA         NA       NA    
## ASV7321             NA         NA         NA       NA    
## ASV8780             NA         NA         NA       NA    
## ASV1569             NA         NA         NA       NA    
## ASV3696             NA         NA         NA       NA    
## ASV0624             NA         NA         NA       NA    
## ASV0495             NA         NA         NA       NA    
## ASV16971            NA         NA         NA       NA    
## ASV6535             NA         NA         NA       NA    
## ASV1897             NA         NA         NA       NA    
## ASV2631             NA         NA         NA       NA    
## ASV6204             NA         NA         NA       NA    
## ASV3312             NA         NA         NA       NA    
## ASV3360             NA         NA         NA       NA    
## ASV3907             NA         NA         NA       NA    
## ASV6090             NA         NA         NA       NA    
## ASV8652             NA         NA         NA       NA    
## ASV11129            NA         NA         NA       NA    
## ASV11073            NA         NA         NA       NA    
## ASV1840             NA         NA         NA       NA    
## ASV2298             NA         NA         NA       NA    
## ASV2420             NA         NA         NA       NA    
## ASV6474             NA         NA         NA       NA    
## ASV8475             NA         NA         NA       NA    
## ASV8679             NA         NA         NA       NA    
## ASV6527             NA         NA         NA       NA    
## ASV2504             NA         NA         NA       NA    
## ASV1093             NA         NA         NA       NA    
## ASV0994             NA         NA         NA       NA    
## ASV0092             NA         NA         NA       NA    
## ASV2619             NA         NA         NA       NA    
## ASV0121             NA         NA         NA       NA    
## ASV0932             NA         NA         NA       NA    
## ASV5229             NA         NA         NA       NA    
## ASV6737             NA         NA         NA       NA    
## ASV11213            NA         NA         NA       NA    
## ASV1151             NA         NA         NA       NA    
## ASV3813             NA         NA         NA       NA    
## ASV5566             NA         NA         NA       NA    
## ASV7529             NA         NA         NA       NA    
## ASV2193             NA         NA         NA       NA    
## ASV2349             NA         NA         NA       NA    
## ASV2387             NA         NA         NA       NA    
## ASV2699             NA         NA         NA       NA    
## ASV3353             NA         NA         NA       NA    
## ASV3621             NA         NA         NA       NA    
## ASV3848             NA         NA         NA       NA    
## ASV4440             NA         NA         NA       NA    
## ASV4751             NA         NA         NA       NA    
## ASV5115             NA         NA         NA       NA    
## ASV5850             NA         NA         NA       NA    
## ASV6293             NA         NA         NA       NA    
## ASV6513             NA         NA         NA       NA    
## ASV7628             NA         NA         NA       NA    
## ASV7658             NA         NA         NA       NA    
## ASV0776             NA         NA         NA       NA    
## ASV10227            NA         NA         NA       NA    
## ASV11965            NA         NA         NA       NA    
## ASV1270             NA         NA         NA       NA    
## ASV13123            NA         NA         NA       NA    
## ASV5828             NA         NA         NA       NA    
## ASV5920             NA         NA         NA       NA    
## ASV6071             NA         NA         NA       NA    
## ASV6723             NA         NA         NA       NA    
## ASV6727             NA         NA         NA       NA    
## ASV7759             NA         NA         NA       NA    
## ASV0733             NA         NA         NA       NA    
## ASV1655             NA         NA         NA       NA    
## ASV0755             NA         NA         NA       NA    
## ASV0796             NA         NA         NA       NA    
## ASV0878             NA         NA         NA       NA    
## ASV4988             NA         NA         NA       NA    
## ASV0083             NA         NA         NA       NA    
## ASV0273             NA         NA         NA       NA    
## ASV3076             NA         NA         NA       NA    
## ASV1513             NA         NA         NA       NA    
## ASV5159             NA         NA         NA       NA    
## ASV3422             NA         NA         NA       NA    
## ASV12230            NA         NA         NA       NA    
## ASV1694             NA         NA         NA       NA    
## ASV1249             NA         NA         NA       NA    
## ASV1697             NA         NA         NA       NA    
## ASV4408             NA         NA         NA       NA    
## ASV0095      4.185e+33  2.057e+37  0.000e+00    1.000    
## ASV0410             NA         NA         NA       NA    
## ASV4642             NA         NA         NA       NA    
## ASV4560             NA         NA         NA       NA    
## ASV7586      1.563e+33  7.193e+36  0.000e+00    1.000    
## ASV4144             NA         NA         NA       NA    
## ASV0327             NA         NA         NA       NA    
## ASV0946             NA         NA         NA       NA    
## ASV3254             NA         NA         NA       NA    
## ASV0349             NA         NA         NA       NA    
## ASV0472             NA         NA         NA       NA    
## ASV1330             NA         NA         NA       NA    
## ASV2605             NA         NA         NA       NA    
## ASV2846             NA         NA         NA       NA    
## ASV3982             NA         NA         NA       NA    
## ASV4116             NA         NA         NA       NA    
## ASV6048             NA         NA         NA       NA    
## ASV1146             NA         NA         NA       NA    
## ASV13362            NA         NA         NA       NA    
## ASV1422             NA         NA         NA       NA    
## ASV3640             NA         NA         NA       NA    
## ASV5404             NA         NA         NA       NA    
## ASV6118             NA         NA         NA       NA    
## ASV1115             NA         NA         NA       NA    
## ASV0888             NA         NA         NA       NA    
## ASV4620             NA         NA         NA       NA    
## ASV3099             NA         NA         NA       NA    
## ASV7099             NA         NA         NA       NA    
## ASV5892             NA         NA         NA       NA    
## ASV6978             NA         NA         NA       NA    
## ASV6555             NA         NA         NA       NA    
## ASV0539             NA         NA         NA       NA    
## ASV4665             NA         NA         NA       NA    
## ASV2210             NA         NA         NA       NA    
## ASV1329             NA         NA         NA       NA    
## ASV7123             NA         NA         NA       NA    
## ASV1260             NA         NA         NA       NA    
## ASV1011             NA         NA         NA       NA    
## ASV4233      2.550e+33  1.286e+37  0.000e+00    1.000    
## ASV1475             NA         NA         NA       NA    
## ASV6099             NA         NA         NA       NA    
## ASV1428             NA         NA         NA       NA    
## ASV5101             NA         NA         NA       NA    
## ASV11827            NA         NA         NA       NA    
## ASV13899            NA         NA         NA       NA    
## ASV21259            NA         NA         NA       NA    
## ASV6635             NA         NA         NA       NA    
## ASV9922             NA         NA         NA       NA    
## ASV2869             NA         NA         NA       NA    
## ASV1740             NA         NA         NA       NA    
## ASV4406             NA         NA         NA       NA    
## ASV5586             NA         NA         NA       NA    
## ASV3255             NA         NA         NA       NA    
## ASV12281            NA         NA         NA       NA    
## ASV5388             NA         NA         NA       NA    
## ASV17660            NA         NA         NA       NA    
## ASV0159             NA         NA         NA       NA    
## ASV2734             NA         NA         NA       NA    
## ASV2049             NA         NA         NA       NA    
## ASV2465             NA         NA         NA       NA    
## ASV2147             NA         NA         NA       NA    
## ASV3113             NA         NA         NA       NA    
## ASV0622             NA         NA         NA       NA    
## ASV0437             NA         NA         NA       NA    
## ASV6385             NA         NA         NA       NA    
## ASV3699      3.631e+33  1.523e+37  0.000e+00    1.000    
## ASV2208      5.399e+33  1.989e+37  0.000e+00    1.000    
## ASV1053             NA         NA         NA       NA    
## ASV8468             NA         NA         NA       NA    
## ASV0951             NA         NA         NA       NA    
## ASV0278             NA         NA         NA       NA    
## ASV0914             NA         NA         NA       NA    
## ASV0737             NA         NA         NA       NA    
## ASV2038             NA         NA         NA       NA    
## ASV2171             NA         NA         NA       NA    
## ASV2607             NA         NA         NA       NA    
## ASV3143             NA         NA         NA       NA    
## ASV3187             NA         NA         NA       NA    
## ASV3810             NA         NA         NA       NA    
## ASV5060             NA         NA         NA       NA    
## ASV5325             NA         NA         NA       NA    
## ASV6905             NA         NA         NA       NA    
## ASV7597             NA         NA         NA       NA    
## ASV9652             NA         NA         NA       NA    
## ASV2634             NA         NA         NA       NA    
## ASV3065             NA         NA         NA       NA    
## ASV3331             NA         NA         NA       NA    
## ASV7434             NA         NA         NA       NA    
## ASV7720             NA         NA         NA       NA    
## ASV8414             NA         NA         NA       NA    
## ASV12139            NA         NA         NA       NA    
## ASV1824             NA         NA         NA       NA    
## ASV2094             NA         NA         NA       NA    
## ASV2770             NA         NA         NA       NA    
## ASV3505             NA         NA         NA       NA    
## ASV1935             NA         NA         NA       NA    
## ASV5764             NA         NA         NA       NA    
## ASV6806             NA         NA         NA       NA    
## ASV6942             NA         NA         NA       NA    
## ASV1166             NA         NA         NA       NA    
## ASV1664             NA         NA         NA       NA    
## ASV2568             NA         NA         NA       NA    
## ASV3525             NA         NA         NA       NA    
## ASV4965             NA         NA         NA       NA    
## ASV6607             NA         NA         NA       NA    
## ASV7187             NA         NA         NA       NA    
## ASV0388             NA         NA         NA       NA    
## ASV1420             NA         NA         NA       NA    
## ASV14293            NA         NA         NA       NA    
## ASV17785            NA         NA         NA       NA    
## ASV7678             NA         NA         NA       NA    
## ASV2253             NA         NA         NA       NA    
## ASV4150             NA         NA         NA       NA    
## ASV3836             NA         NA         NA       NA    
## ASV16231            NA         NA         NA       NA    
## ASV2730             NA         NA         NA       NA    
## ASV2072             NA         NA         NA       NA    
## ASV2160             NA         NA         NA       NA    
## ASV5013             NA         NA         NA       NA    
## ASV2586             NA         NA         NA       NA    
## ASV1442             NA         NA         NA       NA    
## ASV3101             NA         NA         NA       NA    
## ASV3323             NA         NA         NA       NA    
## ASV1812             NA         NA         NA       NA    
## ASV6120             NA         NA         NA       NA    
## ASV2565             NA         NA         NA       NA    
## ASV6687             NA         NA         NA       NA    
## ASV5357             NA         NA         NA       NA    
## ASV9383             NA         NA         NA       NA    
## ASV11753            NA         NA         NA       NA    
## ASV11512            NA         NA         NA       NA    
## ASV2791             NA         NA         NA       NA    
## ASV0664             NA         NA         NA       NA    
## ASV3436             NA         NA         NA       NA    
## ASV5755             NA         NA         NA       NA    
## ASV10970            NA         NA         NA       NA    
## ASV11798            NA         NA         NA       NA    
## ASV18193            NA         NA         NA       NA    
## ASV2548             NA         NA         NA       NA    
## ASV3901             NA         NA         NA       NA    
## ASV5197             NA         NA         NA       NA    
## ASV5859             NA         NA         NA       NA    
## ASV6240             NA         NA         NA       NA    
## ASV7281             NA         NA         NA       NA    
## ASV7635             NA         NA         NA       NA    
## ASV8822             NA         NA         NA       NA    
## ASV4810             NA         NA         NA       NA    
## ASV5308             NA         NA         NA       NA    
## ASV2749             NA         NA         NA       NA    
## ASV0298             NA         NA         NA       NA    
## ASV2597             NA         NA         NA       NA    
## ASV5758             NA         NA         NA       NA    
## ASV9987             NA         NA         NA       NA    
## ASV0971             NA         NA         NA       NA    
## ASV0627             NA         NA         NA       NA    
## ASV1758             NA         NA         NA       NA    
## ASV4559             NA         NA         NA       NA    
## ASV11400            NA         NA         NA       NA    
## ASV11559            NA         NA         NA       NA    
## ASV3943             NA         NA         NA       NA    
## ASV10389            NA         NA         NA       NA    
## ASV5168             NA         NA         NA       NA    
## ASV5724             NA         NA         NA       NA    
## ASV6337             NA         NA         NA       NA    
## ASV11063            NA         NA         NA       NA    
## ASV4279             NA         NA         NA       NA    
## ASV7660             NA         NA         NA       NA    
## ASV8218             NA         NA         NA       NA    
## ASV3574             NA         NA         NA       NA    
## ASV12050            NA         NA         NA       NA    
## ASV3897             NA         NA         NA       NA    
## ASV3856             NA         NA         NA       NA    
## ASV3024             NA         NA         NA       NA    
## ASV8715             NA         NA         NA       NA    
## ASV6917             NA         NA         NA       NA    
## ASV1132             NA         NA         NA       NA    
## ASV3583             NA         NA         NA       NA    
## ASV0328             NA         NA         NA       NA    
## ASV0915             NA         NA         NA       NA    
## ASV2677             NA         NA         NA       NA    
## ASV0599             NA         NA         NA       NA    
## ASV0283             NA         NA         NA       NA    
## ASV1028             NA         NA         NA       NA    
## ASV0523             NA         NA         NA       NA    
## ASV8201             NA         NA         NA       NA    
## ASV2795             NA         NA         NA       NA    
## ASV3563             NA         NA         NA       NA    
## ASV1553             NA         NA         NA       NA    
## ASV7155             NA         NA         NA       NA    
## ASV0365             NA         NA         NA       NA    
## ASV8583             NA         NA         NA       NA    
## ASV5400             NA         NA         NA       NA    
## ASV5908             NA         NA         NA       NA    
## ASV2075             NA         NA         NA       NA    
## ASV2520             NA         NA         NA       NA    
## ASV9596             NA         NA         NA       NA    
## ASV1131             NA         NA         NA       NA    
## ASV0579             NA         NA         NA       NA    
## ASV0288             NA         NA         NA       NA    
## ASV4053             NA         NA         NA       NA    
## ASV1736             NA         NA         NA       NA    
## ASV1254             NA         NA         NA       NA    
## ASV9038             NA         NA         NA       NA    
## ASV4746             NA         NA         NA       NA    
## ASV5803             NA         NA         NA       NA    
## ASV0525             NA         NA         NA       NA    
## ASV1974             NA         NA         NA       NA    
## ASV1827             NA         NA         NA       NA    
## ASV30780            NA         NA         NA       NA    
## ASV9342             NA         NA         NA       NA    
## ASV21626            NA         NA         NA       NA    
## ASV1232             NA         NA         NA       NA    
## ASV5578             NA         NA         NA       NA    
## ASV5868             NA         NA         NA       NA    
## ASV13625            NA         NA         NA       NA    
## ASV3614             NA         NA         NA       NA    
## ASV2128             NA         NA         NA       NA    
## ASV5086             NA         NA         NA       NA    
## ASV6614             NA         NA         NA       NA    
## ASV9451             NA         NA         NA       NA    
## ASV9533             NA         NA         NA       NA    
## ASV10697            NA         NA         NA       NA    
## ASV1473             NA         NA         NA       NA    
## ASV1414             NA         NA         NA       NA    
## ASV1567             NA         NA         NA       NA    
## ASV6395             NA         NA         NA       NA    
## ASV2366             NA         NA         NA       NA    
## ASV2537             NA         NA         NA       NA    
## ASV5378             NA         NA         NA       NA    
## ASV5929             NA         NA         NA       NA    
## ASV6360             NA         NA         NA       NA    
## ASV7916             NA         NA         NA       NA    
## ASV13322            NA         NA         NA       NA    
## ASV6207             NA         NA         NA       NA    
## ASV8823             NA         NA         NA       NA    
## ASV1379             NA         NA         NA       NA    
## ASV3259             NA         NA         NA       NA    
## ASV18748            NA         NA         NA       NA    
## ASV3570             NA         NA         NA       NA    
## ASV0790             NA         NA         NA       NA    
## ASV5149             NA         NA         NA       NA    
## ASV1730             NA         NA         NA       NA    
## ASV3488             NA         NA         NA       NA    
## ASV5486             NA         NA         NA       NA    
## ASV1319             NA         NA         NA       NA    
## ASV15328            NA         NA         NA       NA    
## ASV5994             NA         NA         NA       NA    
## ASV4992             NA         NA         NA       NA    
## ASV1788             NA         NA         NA       NA    
## ASV3264             NA         NA         NA       NA    
## ASV4895             NA         NA         NA       NA    
## ASV9218             NA         NA         NA       NA    
## ASV0736             NA         NA         NA       NA    
## ASV0916             NA         NA         NA       NA    
## ASV15761            NA         NA         NA       NA    
## ASV4191             NA         NA         NA       NA    
## ASV3268             NA         NA         NA       NA    
## ASV15321            NA         NA         NA       NA    
## ASV0708             NA         NA         NA       NA    
## ASV4100             NA         NA         NA       NA    
## ASV1627             NA         NA         NA       NA    
## ASV7045             NA         NA         NA       NA    
## ASV3271             NA         NA         NA       NA    
## ASV6200             NA         NA         NA       NA    
## ASV2727             NA         NA         NA       NA    
## ASV3523             NA         NA         NA       NA    
## ASV2259             NA         NA         NA       NA    
## ASV0181             NA         NA         NA       NA    
## ASV1680             NA         NA         NA       NA    
## ASV0176             NA         NA         NA       NA    
## ASV10458            NA         NA         NA       NA    
## ASV10658            NA         NA         NA       NA    
## ASV16807            NA         NA         NA       NA    
## ASV2113             NA         NA         NA       NA    
## ASV2403             NA         NA         NA       NA    
## ASV2484             NA         NA         NA       NA    
## ASV8876             NA         NA         NA       NA    
## ASV0386             NA         NA         NA       NA    
## ASV0351             NA         NA         NA       NA    
## ASV4942             NA         NA         NA       NA    
## ASV5128             NA         NA         NA       NA    
## ASV3496             NA         NA         NA       NA    
## ASV3329             NA         NA         NA       NA    
## ASV7878             NA         NA         NA       NA    
## ASV8251             NA         NA         NA       NA    
## ASV15958            NA         NA         NA       NA    
## ASV7972             NA         NA         NA       NA    
## ASV2088             NA         NA         NA       NA    
## ASV3054             NA         NA         NA       NA    
## ASV4494             NA         NA         NA       NA    
## ASV0087             NA         NA         NA       NA    
## ASV1614             NA         NA         NA       NA    
## ASV3037             NA         NA         NA       NA    
## ASV6615             NA         NA         NA       NA    
## ASV1027             NA         NA         NA       NA    
## ASV2754             NA         NA         NA       NA    
## ASV0536             NA         NA         NA       NA    
## ASV2318             NA         NA         NA       NA    
## ASV5954             NA         NA         NA       NA    
## ASV9028             NA         NA         NA       NA    
## ASV6600             NA         NA         NA       NA    
## ASV1923             NA         NA         NA       NA    
## ASV4034             NA         NA         NA       NA    
## ASV9933             NA         NA         NA       NA    
## ASV1575             NA         NA         NA       NA    
## ASV7812             NA         NA         NA       NA    
## ASV0515             NA         NA         NA       NA    
## ASV1149             NA         NA         NA       NA    
## ASV3791             NA         NA         NA       NA    
## ASV4065             NA         NA         NA       NA    
## ASV10631            NA         NA         NA       NA    
## ASV2359             NA         NA         NA       NA    
## ASV3206             NA         NA         NA       NA    
## ASV4415             NA         NA         NA       NA    
## ASV4467             NA         NA         NA       NA    
## ASV5598             NA         NA         NA       NA    
## ASV5910             NA         NA         NA       NA    
## ASV9494             NA         NA         NA       NA    
## ASV6548             NA         NA         NA       NA    
## ASV8669             NA         NA         NA       NA    
## ASV0674             NA         NA         NA       NA    
## ASV0061             NA         NA         NA       NA    
## ASV0310             NA         NA         NA       NA    
## ASV0582             NA         NA         NA       NA    
## ASV0739             NA         NA         NA       NA    
## ASV1557             NA         NA         NA       NA    
## ASV0146             NA         NA         NA       NA    
## ASV3832             NA         NA         NA       NA    
## ASV0734             NA         NA         NA       NA    
## ASV3036             NA         NA         NA       NA    
## ASV0240             NA         NA         NA       NA    
## ASV2513             NA         NA         NA       NA    
## ASV1118             NA         NA         NA       NA    
## ASV7286             NA         NA         NA       NA    
## ASV1077             NA         NA         NA       NA    
## ASV1255             NA         NA         NA       NA    
## ASV1794             NA         NA         NA       NA    
## ASV2439             NA         NA         NA       NA    
## ASV2467             NA         NA         NA       NA    
## ASV3346             NA         NA         NA       NA    
## ASV3973             NA         NA         NA       NA    
## ASV4521             NA         NA         NA       NA    
## ASV1909             NA         NA         NA       NA    
## ASV3855             NA         NA         NA       NA    
## ASV0810             NA         NA         NA       NA    
## ASV1765             NA         NA         NA       NA    
## ASV0763             NA         NA         NA       NA    
## ASV0302             NA         NA         NA       NA    
## ASV2643             NA         NA         NA       NA    
## ASV0440             NA         NA         NA       NA    
## ASV4899             NA         NA         NA       NA    
## ASV0287             NA         NA         NA       NA    
## ASV3220             NA         NA         NA       NA    
## ASV1007             NA         NA         NA       NA    
## ASV2929             NA         NA         NA       NA    
## ASV1496             NA         NA         NA       NA    
## ASV4975             NA         NA         NA       NA    
## ASV4392             NA         NA         NA       NA    
## ASV4653             NA         NA         NA       NA    
## ASV0230             NA         NA         NA       NA    
## ASV0840             NA         NA         NA       NA    
## ASV4132             NA         NA         NA       NA    
## ASV3344             NA         NA         NA       NA    
## ASV12096            NA         NA         NA       NA    
## ASV1550             NA         NA         NA       NA    
## ASV3542             NA         NA         NA       NA    
## ASV8795             NA         NA         NA       NA    
## ASV2532             NA         NA         NA       NA    
## ASV3087             NA         NA         NA       NA    
## ASV9476             NA         NA         NA       NA    
## ASV13721            NA         NA         NA       NA    
## ASV3842             NA         NA         NA       NA    
## ASV1663             NA         NA         NA       NA    
## ASV0432             NA         NA         NA       NA    
## ASV4356             NA         NA         NA       NA    
## ASV4524             NA         NA         NA       NA    
## ASV0169             NA         NA         NA       NA    
## ASV0368             NA         NA         NA       NA    
## ASV2603             NA         NA         NA       NA    
## ASV3777             NA         NA         NA       NA    
## ASV3978             NA         NA         NA       NA    
## ASV0413             NA         NA         NA       NA    
## ASV0997             NA         NA         NA       NA    
## ASV1195             NA         NA         NA       NA    
## ASV2522             NA         NA         NA       NA    
## ASV4733             NA         NA         NA       NA    
## ASV1063             NA         NA         NA       NA    
## ASV0612             NA         NA         NA       NA    
## ASV1903             NA         NA         NA       NA    
## ASV3576             NA         NA         NA       NA    
## ASV4285             NA         NA         NA       NA    
## ASV3406             NA         NA         NA       NA    
## ASV2379             NA         NA         NA       NA    
## ASV0528             NA         NA         NA       NA    
## ASV6190             NA         NA         NA       NA    
## ASV1537             NA         NA         NA       NA    
## ASV16780            NA         NA         NA       NA    
## ASV0477             NA         NA         NA       NA    
## ASV1499             NA         NA         NA       NA    
## ASV14736            NA         NA         NA       NA    
## ASV0179             NA         NA         NA       NA    
## ASV3153             NA         NA         NA       NA    
## ASV0266             NA         NA         NA       NA    
## ASV0761             NA         NA         NA       NA    
## ASV0269             NA         NA         NA       NA    
## ASV7259             NA         NA         NA       NA    
## ASV2067             NA         NA         NA       NA    
## ASV2985             NA         NA         NA       NA    
## ASV0975             NA         NA         NA       NA    
## ASV2240             NA         NA         NA       NA    
## ASV2297             NA         NA         NA       NA    
## ASV2657             NA         NA         NA       NA    
## ASV3784             NA         NA         NA       NA    
## ASV4333             NA         NA         NA       NA    
## ASV5547             NA         NA         NA       NA    
## ASV5813             NA         NA         NA       NA    
## ASV8049             NA         NA         NA       NA    
## ASV8661             NA         NA         NA       NA    
## ASV9510             NA         NA         NA       NA    
## ASV1401             NA         NA         NA       NA    
## ASV1417             NA         NA         NA       NA    
## ASV2169             NA         NA         NA       NA    
## ASV5354             NA         NA         NA       NA    
## ASV5379             NA         NA         NA       NA    
## ASV6078             NA         NA         NA       NA    
## ASV6417             NA         NA         NA       NA    
## ASV8304             NA         NA         NA       NA    
## ASV8766             NA         NA         NA       NA    
## ASV10861            NA         NA         NA       NA    
## ASV2057             NA         NA         NA       NA    
## ASV4499             NA         NA         NA       NA    
## ASV7415             NA         NA         NA       NA    
## ASV2475             NA         NA         NA       NA    
## ASV3517             NA         NA         NA       NA    
## ASV1864             NA         NA         NA       NA    
## ASV2756             NA         NA         NA       NA    
## ASV0778             NA         NA         NA       NA    
## ASV3201             NA         NA         NA       NA    
## ASV3358             NA         NA         NA       NA    
## ASV5681             NA         NA         NA       NA    
## ASV7256             NA         NA         NA       NA    
## ASV1704             NA         NA         NA       NA    
## ASV4445             NA         NA         NA       NA    
## ASV8649             NA         NA         NA       NA    
## ASV0597             NA         NA         NA       NA    
## ASV0861             NA         NA         NA       NA    
## ASV2423             NA         NA         NA       NA    
## ASV1548             NA         NA         NA       NA    
## ASV2564             NA         NA         NA       NA    
## ASV2999             NA         NA         NA       NA    
## ASV4543             NA         NA         NA       NA    
## ASV8452             NA         NA         NA       NA    
## ASV17287            NA         NA         NA       NA    
## ASV3503             NA         NA         NA       NA    
## ASV4727             NA         NA         NA       NA    
## ASV5995             NA         NA         NA       NA    
## ASV1665             NA         NA         NA       NA    
## ASV2690             NA         NA         NA       NA    
## ASV2823             NA         NA         NA       NA    
## ASV5241             NA         NA         NA       NA    
## ASV5473             NA         NA         NA       NA    
## ASV2785             NA         NA         NA       NA    
## ASV6645             NA         NA         NA       NA    
## ASV0562             NA         NA         NA       NA    
## ASV1163             NA         NA         NA       NA    
## ASV1825             NA         NA         NA       NA    
## ASV3795             NA         NA         NA       NA    
## ASV3869             NA         NA         NA       NA    
## ASV4330             NA         NA         NA       NA    
## ASV6754             NA         NA         NA       NA    
## ASV4598             NA         NA         NA       NA    
## ASV2100             NA         NA         NA       NA    
## ASV3518             NA         NA         NA       NA    
## ASV3823             NA         NA         NA       NA    
## ASV7357             NA         NA         NA       NA    
## ASV7403             NA         NA         NA       NA    
## ASV2934             NA         NA         NA       NA    
## ASV5277             NA         NA         NA       NA    
## ASV0281             NA         NA         NA       NA    
## ASV11181            NA         NA         NA       NA    
## ASV0254             NA         NA         NA       NA    
## ASV0201             NA         NA         NA       NA    
## ASV3656             NA         NA         NA       NA    
## ASV7994             NA         NA         NA       NA    
## ASV3584             NA         NA         NA       NA    
## ASV2157             NA         NA         NA       NA    
## ASV2935             NA         NA         NA       NA    
## ASV9024             NA         NA         NA       NA    
## ASV7711             NA         NA         NA       NA    
## ASV11330            NA         NA         NA       NA    
## ASV1875             NA         NA         NA       NA    
## ASV5861             NA         NA         NA       NA    
## ASV11562            NA         NA         NA       NA    
## ASV18559            NA         NA         NA       NA    
## ASV4384             NA         NA         NA       NA    
## ASV1302             NA         NA         NA       NA    
## ASV4673             NA         NA         NA       NA    
## ASV1956             NA         NA         NA       NA    
## ASV3286             NA         NA         NA       NA    
## ASV4866             NA         NA         NA       NA    
## ASV3129             NA         NA         NA       NA    
## ASV4104             NA         NA         NA       NA    
## ASV8983             NA         NA         NA       NA    
## ASV2201             NA         NA         NA       NA    
## ASV3055             NA         NA         NA       NA    
## ASV0534             NA         NA         NA       NA    
## ASV1019             NA         NA         NA       NA    
## ASV18482            NA         NA         NA       NA    
## ASV2694             NA         NA         NA       NA    
## ASV3412             NA         NA         NA       NA    
## ASV4174             NA         NA         NA       NA    
## ASV4281             NA         NA         NA       NA    
## ASV4949             NA         NA         NA       NA    
## ASV5881             NA         NA         NA       NA    
## ASV6299             NA         NA         NA       NA    
## ASV0676             NA         NA         NA       NA    
## ASV1066             NA         NA         NA       NA    
## ASV1300             NA         NA         NA       NA    
## ASV6455             NA         NA         NA       NA    
## ASV3455             NA         NA         NA       NA    
## ASV6531             NA         NA         NA       NA    
## ASV0490             NA         NA         NA       NA    
## ASV2588             NA         NA         NA       NA    
## ASV5364             NA         NA         NA       NA    
## ASV0981             NA         NA         NA       NA    
## ASV1563             NA         NA         NA       NA    
## ASV0376             NA         NA         NA       NA    
## ASV7308             NA         NA         NA       NA    
## ASV4817             NA         NA         NA       NA    
## ASV8716             NA         NA         NA       NA    
## ASV1849             NA         NA         NA       NA    
## ASV9423             NA         NA         NA       NA    
## ASV7690             NA         NA         NA       NA    
## ASV4901             NA         NA         NA       NA    
## ASV1830             NA         NA         NA       NA    
## ASV2316             NA         NA         NA       NA    
## ASV0693             NA         NA         NA       NA    
## ASV1243             NA         NA         NA       NA    
## ASV3867             NA         NA         NA       NA    
## ASV7932             NA         NA         NA       NA    
## ASV12608            NA         NA         NA       NA    
## ASV1661             NA         NA         NA       NA    
## ASV3957             NA         NA         NA       NA    
## ASV0830             NA         NA         NA       NA    
## ASV2078             NA         NA         NA       NA    
## ASV13932            NA         NA         NA       NA    
## ASV5300             NA         NA         NA       NA    
## ASV1014             NA         NA         NA       NA    
## ASV13059            NA         NA         NA       NA    
## ASV4340             NA         NA         NA       NA    
## ASV5591             NA         NA         NA       NA    
## ASV6040             NA         NA         NA       NA    
## ASV3904             NA         NA         NA       NA    
## ASV2267             NA         NA         NA       NA    
## ASV0573             NA         NA         NA       NA    
## ASV0851             NA         NA         NA       NA    
## ASV7805             NA         NA         NA       NA    
## ASV3379             NA         NA         NA       NA    
## ASV0825             NA         NA         NA       NA    
## ASV2461             NA         NA         NA       NA    
## ASV2783             NA         NA         NA       NA    
## ASV0925             NA         NA         NA       NA    
## ASV7023             NA         NA         NA       NA    
## ASV5319             NA         NA         NA       NA    
## ASV3213             NA         NA         NA       NA    
## ASV3748             NA         NA         NA       NA    
## ASV5491             NA         NA         NA       NA    
## ASV7931             NA         NA         NA       NA    
## ASV12767            NA         NA         NA       NA    
## ASV6389             NA         NA         NA       NA    
## ASV14867            NA         NA         NA       NA    
## ASV5105             NA         NA         NA       NA    
## ASV15927            NA         NA         NA       NA    
## ASV2004             NA         NA         NA       NA    
## ASV5554             NA         NA         NA       NA    
## ASV10929            NA         NA         NA       NA    
## ASV12778            NA         NA         NA       NA    
## ASV14006            NA         NA         NA       NA    
## ASV1603             NA         NA         NA       NA    
## ASV11948            NA         NA         NA       NA    
## ASV12912            NA         NA         NA       NA    
## ASV13147            NA         NA         NA       NA    
## ASV14761            NA         NA         NA       NA    
## ASV8521             NA         NA         NA       NA    
## ASV8581             NA         NA         NA       NA    
## ASV9875             NA         NA         NA       NA    
## ASV9986             NA         NA         NA       NA    
## ASV2376             NA         NA         NA       NA    
## ASV17535            NA         NA         NA       NA    
## ASV14330            NA         NA         NA       NA    
## ASV1333             NA         NA         NA       NA    
## ASV2498             NA         NA         NA       NA    
## ASV6352             NA         NA         NA       NA    
## ASV8601             NA         NA         NA       NA    
## ASV9776             NA         NA         NA       NA    
## ASV1916             NA         NA         NA       NA    
## ASV1555             NA         NA         NA       NA    
## ASV2499             NA         NA         NA       NA    
## ASV0703             NA         NA         NA       NA    
## ASV2047             NA         NA         NA       NA    
## ASV5492             NA         NA         NA       NA    
## ASV6549             NA         NA         NA       NA    
## ASV7757             NA         NA         NA       NA    
## ASV0173             NA         NA         NA       NA    
## ASV1248             NA         NA         NA       NA    
## ASV6502             NA         NA         NA       NA    
## ASV9844             NA         NA         NA       NA    
## ASV3903             NA         NA         NA       NA    
## ASV8199             NA         NA         NA       NA    
## ASV3309             NA         NA         NA       NA    
## ASV5826             NA         NA         NA       NA    
## ASV1480             NA         NA         NA       NA    
## ASV3090             NA         NA         NA       NA    
## ASV0758             NA         NA         NA       NA    
## ASV0811             NA         NA         NA       NA    
## ASV2653             NA         NA         NA       NA    
## ASV0978             NA         NA         NA       NA    
## ASV6640             NA         NA         NA       NA    
## ASV3423             NA         NA         NA       NA    
## ASV0617             NA         NA         NA       NA    
## ASV14947            NA         NA         NA       NA    
## ASV18367            NA         NA         NA       NA    
## ASV4574             NA         NA         NA       NA    
## ASV10514            NA         NA         NA       NA    
## ASV11779            NA         NA         NA       NA    
## ASV7528             NA         NA         NA       NA    
## ASV13153            NA         NA         NA       NA    
## ASV7858             NA         NA         NA       NA    
## ASV8722             NA         NA         NA       NA    
## ASV6585             NA         NA         NA       NA    
## ASV3311             NA         NA         NA       NA    
## ASV2469             NA         NA         NA       NA    
## ASV11340            NA         NA         NA       NA    
## ASV1718             NA         NA         NA       NA    
## ASV2117             NA         NA         NA       NA    
## ASV8252             NA         NA         NA       NA    
## ASV8533             NA         NA         NA       NA    
## ASV9507             NA         NA         NA       NA    
## ASV0706             NA         NA         NA       NA    
## ASV10312            NA         NA         NA       NA    
## ASV10696            NA         NA         NA       NA    
## ASV11203            NA         NA         NA       NA    
## ASV12147            NA         NA         NA       NA    
## ASV4602             NA         NA         NA       NA    
## ASV5568             NA         NA         NA       NA    
## ASV6777             NA         NA         NA       NA    
## ASV8749             NA         NA         NA       NA    
## ASV4780             NA         NA         NA       NA    
## ASV10116            NA         NA         NA       NA    
## ASV2907             NA         NA         NA       NA    
## ASV5165             NA         NA         NA       NA    
## ASV6061             NA         NA         NA       NA    
## ASV8082             NA         NA         NA       NA    
## ASV7696             NA         NA         NA       NA    
## ASV0550             NA         NA         NA       NA    
## ASV7745             NA         NA         NA       NA    
## ASV3607             NA         NA         NA       NA    
## ASV3877             NA         NA         NA       NA    
## ASV7667             NA         NA         NA       NA    
## ASV9293             NA         NA         NA       NA    
## ASV11653            NA         NA         NA       NA    
## ASV12850            NA         NA         NA       NA    
## ASV13104            NA         NA         NA       NA    
## ASV14208            NA         NA         NA       NA    
## ASV1552             NA         NA         NA       NA    
## ASV2501             NA         NA         NA       NA    
## ASV2893             NA         NA         NA       NA    
## ASV3084             NA         NA         NA       NA    
## ASV3599             NA         NA         NA       NA    
## ASV3868             NA         NA         NA       NA    
## ASV3917             NA         NA         NA       NA    
## ASV5695             NA         NA         NA       NA    
## ASV0131             NA         NA         NA       NA    
## ASV2847             NA         NA         NA       NA    
## ASV6875             NA         NA         NA       NA    
## ASV1547             NA         NA         NA       NA    
## ASV1501             NA         NA         NA       NA    
## ASV3876             NA         NA         NA       NA    
## ASV3456             NA         NA         NA       NA    
## ASV1194             NA         NA         NA       NA    
## ASV2135             NA         NA         NA       NA    
## ASV1352             NA         NA         NA       NA    
## ASV3208             NA         NA         NA       NA    
## ASV1164             NA         NA         NA       NA    
## ASV3492             NA         NA         NA       NA    
## ASV1601             NA         NA         NA       NA    
## ASV5347             NA         NA         NA       NA    
## ASV0293             NA         NA         NA       NA    
## ASV1509             NA         NA         NA       NA    
## ASV2801             NA         NA         NA       NA    
## ASV2873             NA         NA         NA       NA    
## ASV2162             NA         NA         NA       NA    
## ASV0462             NA         NA         NA       NA    
## ASV5367             NA         NA         NA       NA    
## ASV2715             NA         NA         NA       NA    
## ASV0371             NA         NA         NA       NA    
## ASV8090             NA         NA         NA       NA    
## ASV6320             NA         NA         NA       NA    
## ASV2562             NA         NA         NA       NA    
## ASV1505             NA         NA         NA       NA    
## ASV4924             NA         NA         NA       NA    
## ASV1437             NA         NA         NA       NA    
## ASV3816             NA         NA         NA       NA    
## ASV1969             NA         NA         NA       NA    
## ASV3146             NA         NA         NA       NA    
## ASV0321             NA         NA         NA       NA    
## ASV1020             NA         NA         NA       NA    
## ASV4138             NA         NA         NA       NA    
## ASV0329             NA         NA         NA       NA    
## ASV10647            NA         NA         NA       NA    
## ASV3389             NA         NA         NA       NA    
## ASV6880             NA         NA         NA       NA    
## ASV2624             NA         NA         NA       NA    
## ASV3686             NA         NA         NA       NA    
## ASV12302            NA         NA         NA       NA    
## ASV1184             NA         NA         NA       NA    
## ASV3533             NA         NA         NA       NA    
## ASV1735             NA         NA         NA       NA    
## ASV0483             NA         NA         NA       NA    
## ASV0928             NA         NA         NA       NA    
## ASV12254            NA         NA         NA       NA    
## ASV16025            NA         NA         NA       NA    
## ASV3070             NA         NA         NA       NA    
## ASV1850             NA         NA         NA       NA    
## ASV8946             NA         NA         NA       NA    
## ASV1536             NA         NA         NA       NA    
## ASV4151             NA         NA         NA       NA    
## ASV4585             NA         NA         NA       NA    
## ASV4921             NA         NA         NA       NA    
## ASV6172             NA         NA         NA       NA    
## ASV6375             NA         NA         NA       NA    
## ASV6501             NA         NA         NA       NA    
## ASV17095            NA         NA         NA       NA    
## ASV3679             NA         NA         NA       NA    
## ASV5750             NA         NA         NA       NA    
## ASV5922             NA         NA         NA       NA    
## ASV7323             NA         NA         NA       NA    
## ASV8515             NA         NA         NA       NA    
## ASV8753             NA         NA         NA       NA    
## ASV9197             NA         NA         NA       NA    
## ASV1778             NA         NA         NA       NA    
## ASV1241             NA         NA         NA       NA    
## ASV1717             NA         NA         NA       NA    
## ASV1112             NA         NA         NA       NA    
## ASV3994             NA         NA         NA       NA    
## ASV5511             NA         NA         NA       NA    
## ASV8706             NA         NA         NA       NA    
## ASV3049             NA         NA         NA       NA    
## ASV4332             NA         NA         NA       NA    
## ASV7411             NA         NA         NA       NA    
## ASV7475             NA         NA         NA       NA    
## ASV8988             NA         NA         NA       NA    
## ASV0688             NA         NA         NA       NA    
## ASV1946             NA         NA         NA       NA    
## ASV3150             NA         NA         NA       NA    
## ASV3508             NA         NA         NA       NA    
## ASV3863             NA         NA         NA       NA    
## ASV4544             NA         NA         NA       NA    
## ASV4567             NA         NA         NA       NA    
## ASV4855             NA         NA         NA       NA    
## ASV4872             NA         NA         NA       NA    
## ASV4881             NA         NA         NA       NA    
## ASV5283             NA         NA         NA       NA    
## ASV5302             NA         NA         NA       NA    
## ASV5909             NA         NA         NA       NA    
## ASV5933             NA         NA         NA       NA    
## ASV6019             NA         NA         NA       NA    
## ASV6043             NA         NA         NA       NA    
## ASV6908             NA         NA         NA       NA    
## ASV7245             NA         NA         NA       NA    
## ASV7249             NA         NA         NA       NA    
## ASV8349             NA         NA         NA       NA    
## ASV7310             NA         NA         NA       NA    
## ASV1893             NA         NA         NA       NA    
## ASV2354             NA         NA         NA       NA    
## ASV3435             NA         NA         NA       NA    
## ASV0480             NA         NA         NA       NA    
## ASV0955             NA         NA         NA       NA    
## ASV10000            NA         NA         NA       NA    
## ASV7215             NA         NA         NA       NA    
## ASV10423            NA         NA         NA       NA    
## ASV6008             NA         NA         NA       NA    
## ASV9330             NA         NA         NA       NA    
## ASV6051             NA         NA         NA       NA    
## ASV1675             NA         NA         NA       NA    
## ASV2043             NA         NA         NA       NA    
## ASV3634             NA         NA         NA       NA    
## ASV4077             NA         NA         NA       NA    
## ASV4754             NA         NA         NA       NA    
## ASV6095             NA         NA         NA       NA    
## ASV6288             NA         NA         NA       NA    
## ASV6507             NA         NA         NA       NA    
## ASV8905             NA         NA         NA       NA    
## ASV9728             NA         NA         NA       NA    
## ASV11144            NA         NA         NA       NA    
## ASV1615             NA         NA         NA       NA    
## ASV2709             NA         NA         NA       NA    
## ASV3003             NA         NA         NA       NA    
## ASV5163             NA         NA         NA       NA    
## ASV6622             NA         NA         NA       NA    
## ASV1076             NA         NA         NA       NA    
## ASV7895             NA         NA         NA       NA    
## ASV10577            NA         NA         NA       NA    
## ASV1272             NA         NA         NA       NA    
## ASV2492             NA         NA         NA       NA    
## ASV5195             NA         NA         NA       NA    
## ASV5267             NA         NA         NA       NA    
## ASV6317             NA         NA         NA       NA    
## ASV2296             NA         NA         NA       NA    
## ASV2290             NA         NA         NA       NA    
## ASV3726             NA         NA         NA       NA    
## ASV1169             NA         NA         NA       NA    
## ASV0189             NA         NA         NA       NA    
## ASV2729             NA         NA         NA       NA    
## ASV3469             NA         NA         NA       NA    
## ASV0762             NA         NA         NA       NA    
## ASV9001             NA         NA         NA       NA    
## ASV14604            NA         NA         NA       NA    
## ASV7439             NA         NA         NA       NA    
## ASV8625             NA         NA         NA       NA    
## ASV11553            NA         NA         NA       NA    
## ASV14440            NA         NA         NA       NA    
## ASV16106            NA         NA         NA       NA    
## ASV16110            NA         NA         NA       NA    
## ASV2229             NA         NA         NA       NA    
## ASV3854             NA         NA         NA       NA    
## ASV5512             NA         NA         NA       NA    
## ASV5939             NA         NA         NA       NA    
## ASV6676             NA         NA         NA       NA    
## ASV8381             NA         NA         NA       NA    
## ASV2735             NA         NA         NA       NA    
## ASV9816             NA         NA         NA       NA    
## ASV1382             NA         NA         NA       NA    
## ASV1408             NA         NA         NA       NA    
## ASV4902             NA         NA         NA       NA    
## ASV5600             NA         NA         NA       NA    
## ASV0815             NA         NA         NA       NA    
## ASV11867            NA         NA         NA       NA    
## ASV16064            NA         NA         NA       NA    
## ASV2250             NA         NA         NA       NA    
## ASV2417             NA         NA         NA       NA    
## ASV2807             NA         NA         NA       NA    
## ASV3224             NA         NA         NA       NA    
## ASV4115             NA         NA         NA       NA    
## ASV4876             NA         NA         NA       NA    
## ASV5291             NA         NA         NA       NA    
## ASV5834             NA         NA         NA       NA    
## ASV6896             NA         NA         NA       NA    
## ASV7292             NA         NA         NA       NA    
## ASV7924             NA         NA         NA       NA    
## ASV0710             NA         NA         NA       NA    
## ASV1925             NA         NA         NA       NA    
## ASV4247             NA         NA         NA       NA    
## ASV4549             NA         NA         NA       NA    
## ASV4076             NA         NA         NA       NA    
## ASV7063             NA         NA         NA       NA    
## ASV1487             NA         NA         NA       NA    
## ASV1405             NA         NA         NA       NA    
## ASV3851             NA         NA         NA       NA    
## ASV0896             NA         NA         NA       NA    
## ASV5581             NA         NA         NA       NA    
## ASV7053             NA         NA         NA       NA    
## ASV7171             NA         NA         NA       NA    
## ASV4017             NA         NA         NA       NA    
## ASV5846             NA         NA         NA       NA    
## ASV0203             NA         NA         NA       NA    
## ASV13271            NA         NA         NA       NA    
## ASV9487             NA         NA         NA       NA    
## ASV2056             NA         NA         NA       NA    
## ASV16933            NA         NA         NA       NA    
## ASV0360             NA         NA         NA       NA    
## ASV1798             NA         NA         NA       NA    
## ASV17286            NA         NA         NA       NA    
## ASV8175             NA         NA         NA       NA    
## ASV6679             NA         NA         NA       NA    
## ASV6776             NA         NA         NA       NA    
## ASV9062             NA         NA         NA       NA    
## ASV9564             NA         NA         NA       NA    
## ASV6431             NA         NA         NA       NA    
## ASV9940             NA         NA         NA       NA    
## ASV7001             NA         NA         NA       NA    
## ASV3044             NA         NA         NA       NA    
## ASV6684             NA         NA         NA       NA    
## ASV12278            NA         NA         NA       NA    
## ASV3543             NA         NA         NA       NA    
## ASV6397             NA         NA         NA       NA    
## ASV9939             NA         NA         NA       NA    
## ASV9432             NA         NA         NA       NA    
## ASV2630             NA         NA         NA       NA    
## ASV2175             NA         NA         NA       NA    
## ASV4107             NA         NA         NA       NA    
## ASV9172             NA         NA         NA       NA    
## ASV3141             NA         NA         NA       NA    
## ASV9010             NA         NA         NA       NA    
## ASV2550             NA         NA         NA       NA    
## ASV5845             NA         NA         NA       NA    
## ASV3998             NA         NA         NA       NA    
## ASV1389             NA         NA         NA       NA    
## ASV0615             NA         NA         NA       NA    
## ASV9127             NA         NA         NA       NA    
## ASV1190             NA         NA         NA       NA    
## ASV1211             NA         NA         NA       NA    
## ASV1766             NA         NA         NA       NA    
## ASV2337             NA         NA         NA       NA    
## ASV2463             NA         NA         NA       NA    
## ASV2806             NA         NA         NA       NA    
## ASV0439             NA         NA         NA       NA    
## ASV0839             NA         NA         NA       NA    
## ASV14975            NA         NA         NA       NA    
## ASV17712            NA         NA         NA       NA    
## ASV2010             NA         NA         NA       NA    
## ASV2041             NA         NA         NA       NA    
## ASV2124             NA         NA         NA       NA    
## ASV2585             NA         NA         NA       NA    
## ASV3314             NA         NA         NA       NA    
## ASV5051             NA         NA         NA       NA    
## ASV10784            NA         NA         NA       NA    
## ASV3279             NA         NA         NA       NA    
## ASV9498             NA         NA         NA       NA    
## ASV1059             NA         NA         NA       NA    
## ASV13008            NA         NA         NA       NA    
## ASV15803            NA         NA         NA       NA    
## ASV2559             NA         NA         NA       NA    
## ASV2623             NA         NA         NA       NA    
## ASV2802             NA         NA         NA       NA    
## ASV3799             NA         NA         NA       NA    
## ASV5274             NA         NA         NA       NA    
## ASV5835             NA         NA         NA       NA    
## ASV7251             NA         NA         NA       NA    
## ASV7616             NA         NA         NA       NA    
## ASV9576             NA         NA         NA       NA    
## ASV2870             NA         NA         NA       NA    
## ASV3668             NA         NA         NA       NA    
## ASV1633             NA         NA         NA       NA    
## ASV6060             NA         NA         NA       NA    
## ASV6305             NA         NA         NA       NA    
## ASV5164             NA         NA         NA       NA    
## ASV7252             NA         NA         NA       NA    
## ASV9343             NA         NA         NA       NA    
## ASV6835             NA         NA         NA       NA    
## ASV1264             NA         NA         NA       NA    
## ASV0591             NA         NA         NA       NA    
## ASV1351             NA         NA         NA       NA    
## ASV14224            NA         NA         NA       NA    
## ASV1432             NA         NA         NA       NA    
## ASV1559             NA         NA         NA       NA    
## ASV2182             NA         NA         NA       NA    
## ASV2304             NA         NA         NA       NA    
## ASV6838             NA         NA         NA       NA    
## ASV1125             NA         NA         NA       NA    
## ASV17948            NA         NA         NA       NA    
## ASV2609             NA         NA         NA       NA    
## ASV6128             NA         NA         NA       NA    
## ASV1338             NA         NA         NA       NA    
## ASV2136             NA         NA         NA       NA    
## ASV0929             NA         NA         NA       NA    
## ASV3479             NA         NA         NA       NA    
## ASV0886             NA         NA         NA       NA    
## ASV1652             NA         NA         NA       NA    
## ASV1160             NA         NA         NA       NA    
## ASV5260             NA         NA         NA       NA    
## ASV2352             NA         NA         NA       NA    
## ASV0986             NA         NA         NA       NA    
## ASV2021             NA         NA         NA       NA    
## ASV16599            NA         NA         NA       NA    
## ASV3497             NA         NA         NA       NA    
## ASV1305             NA         NA         NA       NA    
## ASV0927             NA         NA         NA       NA    
## ASV0647             NA         NA         NA       NA    
## ASV1832             NA         NA         NA       NA    
## ASV1277             NA         NA         NA       NA    
## ASV22332            NA         NA         NA       NA    
## ASV10080            NA         NA         NA       NA    
## ASV14157            NA         NA         NA       NA    
## ASV15829            NA         NA         NA       NA    
## ASV3609             NA         NA         NA       NA    
## ASV5737             NA         NA         NA       NA    
## ASV1474             NA         NA         NA       NA    
## ASV2028             NA         NA         NA       NA    
## ASV0818             NA         NA         NA       NA    
## ASV0505             NA         NA         NA       NA    
## ASV1813             NA         NA         NA       NA    
## ASV0512             NA         NA         NA       NA    
## ASV5374             NA         NA         NA       NA    
## ASV2927             NA         NA         NA       NA    
## ASV3596             NA         NA         NA       NA    
## ASV1137             NA         NA         NA       NA    
## ASV4541             NA         NA         NA       NA    
## ASV9872             NA         NA         NA       NA    
## ASV0359             NA         NA         NA       NA    
## ASV0720             NA         NA         NA       NA    
## ASV10545            NA         NA         NA       NA    
## ASV13384            NA         NA         NA       NA    
## ASV1456             NA         NA         NA       NA    
## ASV1751             NA         NA         NA       NA    
## ASV18419            NA         NA         NA       NA    
## ASV2970             NA         NA         NA       NA    
## ASV4215             NA         NA         NA       NA    
## ASV4742             NA         NA         NA       NA    
## ASV5017             NA         NA         NA       NA    
## ASV5139             NA         NA         NA       NA    
## ASV9133             NA         NA         NA       NA    
## ASV9447             NA         NA         NA       NA    
## ASV0842             NA         NA         NA       NA    
## ASV12293            NA         NA         NA       NA    
## ASV1965             NA         NA         NA       NA    
## ASV2005             NA         NA         NA       NA    
## ASV5335             NA         NA         NA       NA    
## ASV6438             NA         NA         NA       NA    
## ASV7798             NA         NA         NA       NA    
## ASV2691             NA         NA         NA       NA    
## ASV9958             NA         NA         NA       NA    
## ASV1512             NA         NA         NA       NA    
## ASV1226             NA         NA         NA       NA    
## ASV2130             NA         NA         NA       NA    
## ASV0874             NA         NA         NA       NA    
## ASV5436             NA         NA         NA       NA    
## ASV0383             NA         NA         NA       NA    
## ASV1882             NA         NA         NA       NA    
## ASV2471             NA         NA         NA       NA    
## ASV4049             NA         NA         NA       NA    
## ASV3014             NA         NA         NA       NA    
## ASV0316             NA         NA         NA       NA    
## ASV1621             NA         NA         NA       NA    
## ASV13266            NA         NA         NA       NA    
## ASV1635             NA         NA         NA       NA    
## ASV2042             NA         NA         NA       NA    
## ASV2317             NA         NA         NA       NA    
## ASV3697             NA         NA         NA       NA    
## ASV6404             NA         NA         NA       NA    
## ASV15616            NA         NA         NA       NA    
## ASV10783            NA         NA         NA       NA    
## ASV6912             NA         NA         NA       NA    
## ASV1561             NA         NA         NA       NA    
## ASV4404             NA         NA         NA       NA    
## ASV1110             NA         NA         NA       NA    
## ASV2844             NA         NA         NA       NA    
## ASV5224             NA         NA         NA       NA    
## ASV6300             NA         NA         NA       NA    
## ASV8078             NA         NA         NA       NA    
## ASV9722             NA         NA         NA       NA    
## ASV6911             NA         NA         NA       NA    
## ASV5474             NA         NA         NA       NA    
## ASV2761             NA         NA         NA       NA    
## ASV5943             NA         NA         NA       NA    
## ASV0600             NA         NA         NA       NA    
## ASV0608             NA         NA         NA       NA    
## ASV1586             NA         NA         NA       NA    
## ASV0206             NA         NA         NA       NA    
## ASV4042             NA         NA         NA       NA    
## ASV5304             NA         NA         NA       NA    
## ASV0949             NA         NA         NA       NA    
## ASV1856             NA         NA         NA       NA    
## ASV2584             NA         NA         NA       NA    
## ASV2287             NA         NA         NA       NA    
## ASV2364             NA         NA         NA       NA    
## ASV11481            NA         NA         NA       NA    
## ASV2906             NA         NA         NA       NA    
## ASV0161             NA         NA         NA       NA    
## ASV0062             NA         NA         NA       NA    
## ASV3811             NA         NA         NA       NA    
## ASV0225             NA         NA         NA       NA    
## ASV4672             NA         NA         NA       NA    
## ASV1607             NA         NA         NA       NA    
## ASV3060             NA         NA         NA       NA    
## ASV2275             NA         NA         NA       NA    
## ASV5375             NA         NA         NA       NA    
## ASV0352             NA         NA         NA       NA    
## ASV1107             NA         NA         NA       NA    
## ASV4887             NA         NA         NA       NA    
## ASV2397             NA         NA         NA       NA    
## ASV7541             NA         NA         NA       NA    
## ASV7387             NA         NA         NA       NA    
## ASV1355             NA         NA         NA       NA    
## ASV1764             NA         NA         NA       NA    
## ASV1960             NA         NA         NA       NA    
## ASV0484             NA         NA         NA       NA    
## ASV2487             NA         NA         NA       NA    
## ASV0422             NA         NA         NA       NA    
## ASV0081             NA         NA         NA       NA    
## ASV1341             NA         NA         NA       NA    
## ASV1001             NA         NA         NA       NA    
## ASV0317             NA         NA         NA       NA    
## ASV2728             NA         NA         NA       NA    
## ASV0884             NA         NA         NA       NA    
## ASV0464             NA         NA         NA       NA    
## ASV2963             NA         NA         NA       NA    
## ASV4608             NA         NA         NA       NA    
## ASV3534             NA         NA         NA       NA    
## ASV0291             NA         NA         NA       NA    
## ASV0635             NA         NA         NA       NA    
## ASV0867             NA         NA         NA       NA    
## ASV1206             NA         NA         NA       NA    
## ASV1230             NA         NA         NA       NA    
## ASV1265             NA         NA         NA       NA    
## ASV1291             NA         NA         NA       NA    
## ASV1524             NA         NA         NA       NA    
## ASV2153             NA         NA         NA       NA    
## ASV2714             NA         NA         NA       NA    
## ASV4246             NA         NA         NA       NA    
## ASV0945             NA         NA         NA       NA    
## ASV2380             NA         NA         NA       NA    
## ASV0214             NA         NA         NA       NA    
## ASV10461            NA         NA         NA       NA    
## ASV4177             NA         NA         NA       NA    
## ASV0237             NA         NA         NA       NA    
## ASV11323            NA         NA         NA       NA    
## ASV2232             NA         NA         NA       NA    
## ASV0115             NA         NA         NA       NA    
## ASV1171             NA         NA         NA       NA    
## ASV1942             NA         NA         NA       NA    
## ASV1889             NA         NA         NA       NA    
## ASV0920             NA         NA         NA       NA    
## ASV1805             NA         NA         NA       NA    
## ASV1712             NA         NA         NA       NA    
## ASV1458             NA         NA         NA       NA    
## ASV1985             NA         NA         NA       NA    
## ASV2960             NA         NA         NA       NA    
## ASV5207             NA         NA         NA       NA    
## ASV8548             NA         NA         NA       NA    
## ASV0449             NA         NA         NA       NA    
## ASV0609             NA         NA         NA       NA    
## ASV1038             NA         NA         NA       NA    
## ASV1145             NA         NA         NA       NA    
## ASV15767            NA         NA         NA       NA    
## ASV1630             NA         NA         NA       NA    
## ASV1911             NA         NA         NA       NA    
## ASV1950             NA         NA         NA       NA    
## ASV2583             NA         NA         NA       NA    
## ASV2853             NA         NA         NA       NA    
## ASV2948             NA         NA         NA       NA    
## ASV3116             NA         NA         NA       NA    
## ASV3160             NA         NA         NA       NA    
## ASV3354             NA         NA         NA       NA    
## ASV3368             NA         NA         NA       NA    
## ASV3464             NA         NA         NA       NA    
## ASV3577             NA         NA         NA       NA    
## ASV3746             NA         NA         NA       NA    
## ASV3942             NA         NA         NA       NA    
## ASV4000             NA         NA         NA       NA    
## ASV4207             NA         NA         NA       NA    
## ASV4261             NA         NA         NA       NA    
## ASV4466             NA         NA         NA       NA    
## ASV4487             NA         NA         NA       NA    
## ASV4572             NA         NA         NA       NA    
## ASV4718             NA         NA         NA       NA    
## ASV4757             NA         NA         NA       NA    
## ASV4929             NA         NA         NA       NA    
## ASV5611             NA         NA         NA       NA    
## ASV5614             NA         NA         NA       NA    
## ASV5898             NA         NA         NA       NA    
## ASV7627             NA         NA         NA       NA    
## ASV3105             NA         NA         NA       NA    
## ASV4762             NA         NA         NA       NA    
## ASV5622             NA         NA         NA       NA    
## ASV7129             NA         NA         NA       NA    
## ASV12138            NA         NA         NA       NA    
## ASV1687             NA         NA         NA       NA    
## ASV2187             NA         NA         NA       NA    
## ASV2204             NA         NA         NA       NA    
## ASV2914             NA         NA         NA       NA    
## ASV3297             NA         NA         NA       NA    
## ASV3310             NA         NA         NA       NA    
## ASV3677             NA         NA         NA       NA    
## ASV4508             NA         NA         NA       NA    
## ASV6236             NA         NA         NA       NA    
## ASV6285             NA         NA         NA       NA    
## ASV7576             NA         NA         NA       NA    
## ASV7917             NA         NA         NA       NA    
## ASV9353             NA         NA         NA       NA    
## ASV1656             NA         NA         NA       NA    
## ASV0280             NA         NA         NA       NA    
## ASV4747             NA         NA         NA       NA    
## ASV2108             NA         NA         NA       NA    
## ASV0885             NA         NA         NA       NA    
## ASV2538             NA         NA         NA       NA    
## ASV0968             NA         NA         NA       NA    
## ASV1229             NA         NA         NA       NA    
## ASV13306            NA         NA         NA       NA    
## ASV13952            NA         NA         NA       NA    
## ASV14631            NA         NA         NA       NA    
## ASV2119             NA         NA         NA       NA    
## ASV2450             NA         NA         NA       NA    
## ASV2656             NA         NA         NA       NA    
## ASV2942             NA         NA         NA       NA    
## ASV3302             NA         NA         NA       NA    
## ASV6515             NA         NA         NA       NA    
## ASV6674             NA         NA         NA       NA    
## ASV7296             NA         NA         NA       NA    
## ASV7903             NA         NA         NA       NA    
## ASV7943             NA         NA         NA       NA    
## ASV8864             NA         NA         NA       NA    
## ASV9389             NA         NA         NA       NA    
## ASV9869             NA         NA         NA       NA    
## ASV1051             NA         NA         NA       NA    
## ASV13035            NA         NA         NA       NA    
## ASV15744            NA         NA         NA       NA    
## ASV2526             NA         NA         NA       NA    
## ASV1156             NA         NA         NA       NA    
## ASV13562            NA         NA         NA       NA    
## ASV1438             NA         NA         NA       NA    
## ASV2268             NA         NA         NA       NA    
## ASV2797             NA         NA         NA       NA    
## ASV3744             NA         NA         NA       NA    
## ASV8076             NA         NA         NA       NA    
## ASV7055             NA         NA         NA       NA    
## ASV7493             NA         NA         NA       NA    
## ASV1201             NA         NA         NA       NA    
## ASV5736             NA         NA         NA       NA    
## ASV0558             NA         NA         NA       NA    
## ASV14399            NA         NA         NA       NA    
## ASV2992             NA         NA         NA       NA    
## ASV4303             NA         NA         NA       NA    
## ASV0565             NA         NA         NA       NA    
## ASV0977             NA         NA         NA       NA    
## ASV0140             NA         NA         NA       NA    
## ASV14421            NA         NA         NA       NA    
## ASV16909            NA         NA         NA       NA    
## ASV3762             NA         NA         NA       NA    
## ASV7141             NA         NA         NA       NA    
## ASV3291             NA         NA         NA       NA    
## ASV10440            NA         NA         NA       NA    
## ASV10802            NA         NA         NA       NA    
## ASV1698             NA         NA         NA       NA    
## ASV2121             NA         NA         NA       NA    
## ASV3549             NA         NA         NA       NA    
## ASV6379             NA         NA         NA       NA    
## ASV6824             NA         NA         NA       NA    
## ASV8254             NA         NA         NA       NA    
## ASV9951             NA         NA         NA       NA    
## ASV1515             NA         NA         NA       NA    
## ASV4327             NA         NA         NA       NA    
## ASV0341             NA         NA         NA       NA    
## ASV5562             NA         NA         NA       NA    
## ASV1412             NA         NA         NA       NA    
## ASV0154             NA         NA         NA       NA    
## ASV3163             NA         NA         NA       NA    
## ASV1782             NA         NA         NA       NA    
## ASV3993             NA         NA         NA       NA    
## ASV3164             NA         NA         NA       NA    
## ASV1024             NA         NA         NA       NA    
## ASV0771             NA         NA         NA       NA    
## ASV2223             NA         NA         NA       NA    
## ASV1638             NA         NA         NA       NA    
## ASV0232             NA         NA         NA       NA    
## ASV6771             NA         NA         NA       NA    
## ASV4243             NA         NA         NA       NA    
## ASV0162             NA         NA         NA       NA    
## ASV0049             NA         NA         NA       NA    
## ASV4697             NA         NA         NA       NA    
## ASV12326            NA         NA         NA       NA    
## ASV12586            NA         NA         NA       NA    
## ASV1879             NA         NA         NA       NA    
## ASV2864             NA         NA         NA       NA    
## ASV3111             NA         NA         NA       NA    
## ASV5633             NA         NA         NA       NA    
## ASV5864             NA         NA         NA       NA    
## ASV6364             NA         NA         NA       NA    
## ASV1598             NA         NA         NA       NA    
## ASV2649             NA         NA         NA       NA    
## ASV4664             NA         NA         NA       NA    
## ASV2654             NA         NA         NA       NA    
## ASV6636             NA         NA         NA       NA    
## ASV3334             NA         NA         NA       NA    
## ASV0046             NA         NA         NA       NA    
## ASV0661             NA         NA         NA       NA    
## ASV0774             NA         NA         NA       NA    
## ASV3815             NA         NA         NA       NA    
## ASV0575             NA         NA         NA       NA    
## ASV1953             NA         NA         NA       NA    
## ASV0610             NA         NA         NA       NA    
## ASV0245             NA         NA         NA       NA    
## ASV3805             NA         NA         NA       NA    
## ASV1182             NA         NA         NA       NA    
## ASV1941             NA         NA         NA       NA    
## ASV0080             NA         NA         NA       NA    
## ASV1033             NA         NA         NA       NA    
## ASV5330             NA         NA         NA       NA    
## ASV9702             NA         NA         NA       NA    
## ASV0358             NA         NA         NA       NA    
## ASV2225             NA         NA         NA       NA    
## ASV2606             NA         NA         NA       NA    
## ASV3510             NA         NA         NA       NA    
## ASV3069             NA         NA         NA       NA    
## ASV3849             NA         NA         NA       NA    
## ASV1810             NA         NA         NA       NA    
## ASV2046             NA         NA         NA       NA    
## ASV2451             NA         NA         NA       NA    
## ASV4047             NA         NA         NA       NA    
## ASV7402             NA         NA         NA       NA    
## ASV8250             NA         NA         NA       NA    
## ASV3468             NA         NA         NA       NA    
## ASV3521             NA         NA         NA       NA    
## ASV6363             NA         NA         NA       NA    
## ASV6444             NA         NA         NA       NA    
## ASV8231             NA         NA         NA       NA    
## ASV0196             NA         NA         NA       NA    
## ASV12801            NA         NA         NA       NA    
## ASV12906            NA         NA         NA       NA    
## ASV13040            NA         NA         NA       NA    
## ASV1313             NA         NA         NA       NA    
## ASV14008            NA         NA         NA       NA    
## ASV1546             NA         NA         NA       NA    
## ASV1637             NA         NA         NA       NA    
## ASV17076            NA         NA         NA       NA    
## ASV2061             NA         NA         NA       NA    
## ASV2177             NA         NA         NA       NA    
## ASV2943             NA         NA         NA       NA    
## ASV3020             NA         NA         NA       NA    
## ASV30254            NA         NA         NA       NA    
## ASV3219             NA         NA         NA       NA    
## ASV3352             NA         NA         NA       NA    
## ASV3355             NA         NA         NA       NA    
## ASV3377             NA         NA         NA       NA    
## ASV3449             NA         NA         NA       NA    
## ASV3893             NA         NA         NA       NA    
## ASV4326             NA         NA         NA       NA    
## ASV5016             NA         NA         NA       NA    
## ASV5152             NA         NA         NA       NA    
## ASV5666             NA         NA         NA       NA    
## ASV5802             NA         NA         NA       NA    
## ASV6070             NA         NA         NA       NA    
## ASV6488             NA         NA         NA       NA    
## ASV6562             NA         NA         NA       NA    
## ASV6930             NA         NA         NA       NA    
## ASV7243             NA         NA         NA       NA    
## ASV7506             NA         NA         NA       NA    
## ASV7553             NA         NA         NA       NA    
## ASV8064             NA         NA         NA       NA    
## ASV8434             NA         NA         NA       NA    
## ASV8858             NA         NA         NA       NA    
## ASV2600             NA         NA         NA       NA    
## ASV3398             NA         NA         NA       NA    
## ASV4584             NA         NA         NA       NA    
## ASV4864             NA         NA         NA       NA    
## ASV0082             NA         NA         NA       NA    
## ASV9626             NA         NA         NA       NA    
## ASV1617             NA         NA         NA       NA    
## ASV2765             NA         NA         NA       NA    
## ASV2167             NA         NA         NA       NA    
## ASV1628             NA         NA         NA       NA    
## ASV3260             NA         NA         NA       NA    
## ASV3645             NA         NA         NA       NA    
## ASV6057             NA         NA         NA       NA    
## ASV0662             NA         NA         NA       NA    
## ASV4267             NA         NA         NA       NA    
## ASV1070             NA         NA         NA       NA    
## ASV0633             NA         NA         NA       NA    
## ASV0333             NA         NA         NA       NA    
## ASV0966             NA         NA         NA       NA    
## ASV1848             NA         NA         NA       NA    
## ASV13390            NA         NA         NA       NA    
## ASV14901            NA         NA         NA       NA    
## ASV1676             NA         NA         NA       NA    
## ASV1756             NA         NA         NA       NA    
## ASV22537            NA         NA         NA       NA    
## ASV3303             NA         NA         NA       NA    
## ASV4030             NA         NA         NA       NA    
## ASV4871             NA         NA         NA       NA    
## ASV5536             NA         NA         NA       NA    
## ASV5700             NA         NA         NA       NA    
## ASV8957             NA         NA         NA       NA    
## ASV11210            NA         NA         NA       NA    
## ASV7585             NA         NA         NA       NA    
## ASV8596             NA         NA         NA       NA    
## ASV9532             NA         NA         NA       NA    
## ASV4254             NA         NA         NA       NA    
## ASV13299            NA         NA         NA       NA    
## ASV15627            NA         NA         NA       NA    
## ASV6302             NA         NA         NA       NA    
## ASV3040             NA         NA         NA       NA    
## ASV0632             NA         NA         NA       NA    
## ASV3694             NA         NA         NA       NA    
## ASV1592             NA         NA         NA       NA    
## ASV0538             NA         NA         NA       NA    
## ASV0832             NA         NA         NA       NA    
## ASV0727             NA         NA         NA       NA    
## ASV1165             NA         NA         NA       NA    
## ASV1325             NA         NA         NA       NA    
## ASV0819             NA         NA         NA       NA    
## ASV2251             NA         NA         NA       NA    
## ASV0100             NA         NA         NA       NA    
## ASV0444             NA         NA         NA       NA    
## ASV0800             NA         NA         NA       NA    
## ASV2432             NA         NA         NA       NA    
## ASV2883             NA         NA         NA       NA    
## ASV3894             NA         NA         NA       NA    
## ASV2367             NA         NA         NA       NA    
## ASV3724             NA         NA         NA       NA    
## ASV2112             NA         NA         NA       NA    
## ASV3661             NA         NA         NA       NA    
## ASV2096             NA         NA         NA       NA    
## ASV3551             NA         NA         NA       NA    
## ASV11343            NA         NA         NA       NA    
## ASV2051             NA         NA         NA       NA    
## ASV2617             NA         NA         NA       NA    
## ASV0125             NA         NA         NA       NA    
## ASV0372             NA         NA         NA       NA    
## ASV6751             NA         NA         NA       NA    
## ASV10810            NA         NA         NA       NA    
## ASV0461             NA         NA         NA       NA    
## ASV1945             NA         NA         NA       NA    
## ASV0882             NA         NA         NA       NA    
## ASV4040             NA         NA         NA       NA    
## ASV0109             NA         NA         NA       NA    
## ASV0174             NA         NA         NA       NA    
## ASV2851             NA         NA         NA       NA    
## ASV5312             NA         NA         NA       NA    
## ASV9402             NA         NA         NA       NA    
## ASV4870             NA         NA         NA       NA    
## ASV0589             NA         NA         NA       NA    
## ASV1221             NA         NA         NA       NA    
## ASV6028             NA         NA         NA       NA    
## ASV5106             NA         NA         NA       NA    
## ASV4977             NA         NA         NA       NA    
## ASV5715             NA         NA         NA       NA    
## ASV4182             NA         NA         NA       NA    
## ASV2383             NA         NA         NA       NA    
## ASV3985             NA         NA         NA       NA    
## ASV2787             NA         NA         NA       NA    
## ASV6756             NA         NA         NA       NA    
## ASV1634             NA         NA         NA       NA    
## ASV0649             NA         NA         NA       NA    
## ASV1591             NA         NA         NA       NA    
## ASV1854             NA         NA         NA       NA    
## ASV4205             NA         NA         NA       NA    
## ASV3293             NA         NA         NA       NA    
## ASV1631             NA         NA         NA       NA    
## ASV1747             NA         NA         NA       NA    
## ASV5634             NA         NA         NA       NA    
## ASV0965             NA         NA         NA       NA    
## ASV1094             NA         NA         NA       NA    
## ASV2744             NA         NA         NA       NA    
## ASV7212             NA         NA         NA       NA    
## ASV0344             NA         NA         NA       NA    
## ASV11812            NA         NA         NA       NA    
## ASV7867             NA         NA         NA       NA    
## ASV6670             NA         NA         NA       NA    
## ASV10991            NA         NA         NA       NA    
## ASV1281             NA         NA         NA       NA    
## ASV12845            NA         NA         NA       NA    
## ASV1833             NA         NA         NA       NA    
## ASV2211             NA         NA         NA       NA    
## ASV3920             NA         NA         NA       NA    
## ASV4545             NA         NA         NA       NA    
## ASV4710             NA         NA         NA       NA    
## ASV4978             NA         NA         NA       NA    
## ASV9630             NA         NA         NA       NA    
## ASV9797             NA         NA         NA       NA    
## ASV13469            NA         NA         NA       NA    
## ASV14961            NA         NA         NA       NA    
## ASV6259             NA         NA         NA       NA    
## ASV6294             NA         NA         NA       NA    
## ASV6883             NA         NA         NA       NA    
## ASV7041             NA         NA         NA       NA    
## ASV4363             NA         NA         NA       NA    
## ASV1784             NA         NA         NA       NA    
## ASV2140             NA         NA         NA       NA    
## ASV3202             NA         NA         NA       NA    
## ASV6017             NA         NA         NA       NA    
## ASV9129             NA         NA         NA       NA    
## ASV0917             NA         NA         NA       NA    
## ASV10584            NA         NA         NA       NA    
## ASV11218            NA         NA         NA       NA    
## ASV11229            NA         NA         NA       NA    
## ASV11604            NA         NA         NA       NA    
## ASV2103             NA         NA         NA       NA    
## ASV2165             NA         NA         NA       NA    
## ASV2340             NA         NA         NA       NA    
## ASV3738             NA         NA         NA       NA    
## ASV4012             NA         NA         NA       NA    
## ASV4094             NA         NA         NA       NA    
## ASV4454             NA         NA         NA       NA    
## ASV7031             NA         NA         NA       NA    
## ASV7087             NA         NA         NA       NA    
## ASV4159             NA         NA         NA       NA    
## ASV5084             NA         NA         NA       NA    
## ASV6584             NA         NA         NA       NA    
## ASV9614             NA         NA         NA       NA    
## ASV16068            NA         NA         NA       NA    
## ASV2141             NA         NA         NA       NA    
## ASV0395             NA         NA         NA       NA    
## ASV5640             NA         NA         NA       NA    
## ASV2854             NA         NA         NA       NA    
## ASV3825             NA         NA         NA       NA    
## ASV0481             NA         NA         NA       NA    
## ASV3304             NA         NA         NA       NA    
## ASV0445             NA         NA         NA       NA    
## ASV1845             NA         NA         NA       NA    
## ASV3110             NA         NA         NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:   385.39  on 277  degrees of freedom
## Residual deviance: 11750.23  on   0  degrees of freedom
## AIC: 12306
## 
## Number of Fisher Scoring iterations: 8

Recall from Adv ML: - The n << p here is an underdetermined system. There is not a unique solution. - If standard errors of coefficients are very large, which in this case they are, this is not a stable model.

Recall from Regression Classes and Other Course Notes: - Null Deviance is for a model with no predictors; just the intercept. - Null Deviance measures the goodness of fit of a model with no predictors. - ‘$df.null’ is the degrees of freedom for the null model: n-1 observations

pchisq(logreg$null.deviance, logreg$df.null, lower.tail = FALSE)
## [1] 1.735332e-05
# Bad fit in notes had a p-value of 0.9995629 from Ressler
# good fit would be the opposite
pchisq(logreg$deviance, logreg$df.residual, lower.tail = FALSE)
## [1] 0

1000 from the PCA results in Dim 1 to see if it helps some of the issues in modeling

Start with balanced dataset first because will need to be retransformed after first 1000 are subset.

  • They are in order so can simply take first 1000
  • Redo transformation based on relative first 1000
# lr_clr_df %>%
#   select(1:1002) -> lr_clr_df_1000 # because of id column and response column

lr_data[,1:1002] -> lr_data_1000
 
  
bind_cols(lr_data_1000[,1:2], # sample id and Clade columns
          lr_data_1000[,-c(1,2)] %>% clr() # re-do CLR transformation on relative first 1000 PCA
            ) -> lr_clr_df_1000

Logistic with Reduced 1000 ASVs

glmnet::glmnet

1000

Ridge L2 regularization

Make sure to re-do with model.matrix

# y = as.factor(lr_clr_df_1000$Clade)
# x = as.matrix(lr_clr_df_1000[,-c(1,2)])
# 
# #glimpse(y)
# #dim(x)
# 
# library(glmnet)
# lr_model_1000 <- glmnet(x, y, 
#                         family = "binomial", 
#                         #alpha = 1 ,# lasso L1 norm
#                         alpha = 0 # ridge L2 norm
#                 )


library(glmnet)


# Create a formula for model.matrix
formula <- as.formula(paste("Clade ~ .", sep = "", collapse = ""), env = environment(lr_clr_df_1000))

# Create the design matrix
x_matrix <- model.matrix(formula, data = lr_clr_df_1000[,-1])

# Convert the response variable to a numerical vector
y_vector <- as.numeric(lr_clr_df_1000$Clade) - 1  # glmnet expects 0/1 coding for binary response

# Fit the RIDGE model
RR <- glmnet(x_matrix, 
                      y_vector, 
                      alpha = 0,  # RIDGE
                      family = "binomial")
RR
## 
## Call:  glmnet(x = x_matrix, y = y_vector, family = "binomial", alpha = 0) 
## 
##       Df  %Dev  Lambda
## 1   1000  0.00 166.200
## 2   1000  1.13 158.700
## 3   1000  1.18 151.400
## 4   1000  1.23 144.600
## 5   1000  1.29 138.000
## 6   1000  1.35 131.700
## 7   1000  1.41 125.700
## 8   1000  1.47 120.000
## 9   1000  1.54 114.600
## 10  1000  1.61 109.400
## 11  1000  1.68 104.400
## 12  1000  1.75  99.640
## 13  1000  1.83  95.110
## 14  1000  1.91  90.790
## 15  1000  2.00  86.660
## 16  1000  2.09  82.720
## 17  1000  2.18  78.960
## 18  1000  2.28  75.370
## 19  1000  2.38  71.950
## 20  1000  2.48  68.680
## 21  1000  2.59  65.560
## 22  1000  2.70  62.580
## 23  1000  2.82  59.730
## 24  1000  2.94  57.020
## 25  1000  3.07  54.420
## 26  1000  3.20  51.950
## 27  1000  3.33  49.590
## 28  1000  3.47  47.340
## 29  1000  3.62  45.180
## 30  1000  3.77  43.130
## 31  1000  3.93  41.170
## 32  1000  4.09  39.300
## 33  1000  4.26  37.510
## 34  1000  4.44  35.810
## 35  1000  4.62  34.180
## 36  1000  4.81  32.630
## 37  1000  5.00  31.140
## 38  1000  5.21  29.730
## 39  1000  5.41  28.380
## 40  1000  5.63  27.090
## 41  1000  5.85  25.860
## 42  1000  6.08  24.680
## 43  1000  6.32  23.560
## 44  1000  6.56  22.490
## 45  1000  6.82  21.470
## 46  1000  7.08  20.490
## 47  1000  7.35  19.560
## 48  1000  7.62  18.670
## 49  1000  7.91  17.820
## 50  1000  8.20  17.010
## 51  1000  8.50  16.240
## 52  1000  8.81  15.500
## 53  1000  9.13  14.800
## 54  1000  9.46  14.120
## 55  1000  9.79  13.480
## 56  1000 10.14  12.870
## 57  1000 10.49  12.280
## 58  1000 10.86  11.730
## 59  1000 11.23  11.190
## 60  1000 11.61  10.680
## 61  1000 12.00  10.200
## 62  1000 12.40   9.735
## 63  1000 12.81   9.292
## 64  1000 13.23   8.870
## 65  1000 13.65   8.467
## 66  1000 14.09   8.082
## 67  1000 14.50   7.715
## 68  1000 14.95   7.364
## 69  1000 15.41   7.029
## 70  1000 15.88   6.710
## 71  1000 16.36   6.405
## 72  1000 16.85   6.114
## 73  1000 17.34   5.836
## 74  1000 17.85   5.571
## 75  1000 18.36   5.317
## 76  1000 18.88   5.076
## 77  1000 19.41   4.845
## 78  1000 19.95   4.625
## 79  1000 20.50   4.415
## 80  1000 21.05   4.214
## 81  1000 21.61   4.022
## 82  1000 22.18   3.840
## 83  1000 22.75   3.665
## 84  1000 23.34   3.498
## 85  1000 23.93   3.339
## 86  1000 24.52   3.188
## 87  1000 25.12   3.043
## 88  1000 25.73   2.904
## 89  1000 26.35   2.772
## 90  1000 26.96   2.646
## 91  1000 27.59   2.526
## 92  1000 28.22   2.411
## 93  1000 28.85   2.302
## 94  1000 29.49   2.197
## 95  1000 30.14   2.097
## 96  1000 30.78   2.002
## 97  1000 31.43   1.911
## 98  1000 32.09   1.824
## 99  1000 32.74   1.741
## 100 1000 33.40   1.662
summary(RR)
##            Length Class     Mode     
## a0            100 -none-    numeric  
## beta       100100 dgCMatrix S4       
## df            100 -none-    numeric  
## dim             2 -none-    numeric  
## lambda        100 -none-    numeric  
## dev.ratio     100 -none-    numeric  
## nulldev         1 -none-    numeric  
## npasses         1 -none-    numeric  
## jerr            1 -none-    numeric  
## offset          1 -none-    logical  
## classnames      2 -none-    character
## call            5 -none-    call     
## nobs            1 -none-    numeric
#plot(RR)
plot(RR, 
     #xlim = c(0, .1), ylim = c(-0.02, 0.02)
     )

Cross-Validation

RR_cv_results <- cv.glmnet(x_matrix, 
                        y_vector, 
                        family = "binomial",
                        nfolds = 10)
plot(RR_cv_results)

best_RRlambda_1000 <- RR_cv_results$lambda.min

# Refit the model with the selected lambda
best_RRmodel_1000 <- glmnet(x_matrix, y_vector, family = "binomial", 
                            alpha = 0, lambda = best_RRlambda_1000)

coef(best_RRmodel_1000)
## 1002 x 1 sparse Matrix of class "dgCMatrix"
##                        s0
## (Intercept)  1.2206003147
## (Intercept)  .           
## ASV1236      0.1186687767
## ASV0421      0.0413238590
## ASV0691     -0.0059674090
## ASV0899      0.0939806638
## ASV1004      0.2395127350
## ASV1041     -0.0822949898
## ASV1058      0.1696821591
## ASV12542     0.0737439549
## ASV1294      0.1655737768
## ASV13113     0.3966897141
## ASV1318      0.1644354031
## ASV2269     -0.2731736907
## ASV2542      0.2862818247
## ASV2660     -0.1177988544
## ASV2737      0.0121151055
## ASV2840      0.0505992831
## ASV3053      1.2210747441
## ASV3077      0.0544891036
## ASV3134      0.4217794116
## ASV3140      0.0941785101
## ASV3579      0.0949830326
## ASV6119     -0.0320072339
## ASV7557     -0.0644864240
## ASV8422      0.0488106408
## ASV1086     -0.0224396040
## ASV1310      0.0076659514
## ASV15750     0.0297125267
## ASV16905    -0.0129455326
## ASV2033      0.2185553220
## ASV2089      0.0152859587
## ASV2127      0.1855550141
## ASV2725      0.1426344453
## ASV2804     -0.0235440491
## ASV3075      0.2355360063
## ASV3327      0.4795303396
## ASV3342      0.2196093826
## ASV3532     -0.3260831747
## ASV3600      0.1709835322
## ASV4013      0.1393910694
## ASV4136      0.1532576897
## ASV4195      0.2114264503
## ASV4407     -0.0724925175
## ASV4717      0.0674232758
## ASV6794      0.1381027442
## ASV8324     -0.0141779553
## ASV8981      0.0434281427
## ASV9859      0.4002721708
## ASV0936     -0.0378772264
## ASV12683     0.0549649029
## ASV1293      0.0480247320
## ASV13055     0.1045608919
## ASV17063     0.0408175603
## ASV2228     -0.0399750336
## ASV2769      0.0474997935
## ASV2803      0.0947384924
## ASV2896      0.2341363243
## ASV3062      0.1775399084
## ASV3107      0.1749580065
## ASV3265      0.1106353328
## ASV3666      0.0484662304
## ASV4497      0.0898235512
## ASV6914      0.0381858809
## ASV0576     -0.1528774555
## ASV0673      0.1850020766
## ASV0772      0.1632312410
## ASV0862     -0.0594898032
## ASV0898      0.0795157764
## ASV0910      0.1561484392
## ASV0964     -0.1221292070
## ASV10059     0.2821216518
## ASV10263     0.0718085900
## ASV1088      0.4298075425
## ASV1101      0.0502837113
## ASV1183      0.0616025838
## ASV11956     0.0893004126
## ASV12774     0.0258567794
## ASV1321      0.3096918839
## ASV13793     0.0362898336
## ASV14482     0.0419950348
## ASV15483     0.1087900204
## ASV2062      0.1942433712
## ASV2132      0.3611145732
## ASV2413      0.1225415332
## ASV2490      0.1792055446
## ASV2594      0.1662406300
## ASV2822      0.0747440189
## ASV2863      0.1012350799
## ASV2910      0.0697972096
## ASV2980      0.0185915303
## ASV3307     -0.0214167277
## ASV3474      0.1911747692
## ASV3502      0.2659652308
## ASV4236      0.1159399010
## ASV4842      0.0746271135
## ASV4894     -0.0021371537
## ASV5290      0.1092639497
## ASV5501      0.1062661236
## ASV5795      0.0812790864
## ASV5987     -0.0395055999
## ASV6267     -0.0652824315
## ASV6862      0.0670529819
## ASV7145      0.0797773840
## ASV7673     -0.0294443003
## ASV7789      0.1176532884
## ASV7809      0.0338241347
## ASV8002     -0.0561575616
## ASV8205      0.0638233938
## ASV9155      0.0055171087
## ASV9221     -0.0303807231
## ASV9311     -0.1356197187
## ASV9557     -0.1009594682
## ASV9936     -0.2168200841
## ASV1445      0.2179341031
## ASV4232      0.1522465916
## ASV6479      0.2131069795
## ASV0142     -0.0766631408
## ASV0378      0.1045933777
## ASV1122      0.2878568131
## ASV0123     -0.0660661463
## ASV2064      0.0420980214
## ASV4459     -0.0854746287
## ASV0448      0.0653138996
## ASV0397      0.0988328016
## ASV0485      0.1298238946
## ASV1566      0.1602724474
## ASV1365      0.0704644019
## ASV1065      0.2640245788
## ASV0722     -0.0735366682
## ASV12660    -0.0774895244
## ASV0223     -0.0147395319
## ASV0229      0.0835299491
## ASV0877     -0.0465801568
## ASV0983      0.0383241701
## ASV0626      0.0319861346
## ASV4146     -0.1443806489
## ASV4175     -0.1844796290
## ASV2082     -0.2557280638
## ASV2272      0.0542870031
## ASV2245     -0.1380464979
## ASV0590     -0.3972419710
## ASV0217      0.1483468612
## ASV0416     -0.0443419314
## ASV1056      0.1365453625
## ASV7777     -0.9977825658
## ASV0455     -0.0061565577
## ASV0604      0.1053972081
## ASV6100     -0.4326759666
## ASV11359    -0.1735512236
## ASV6604      0.0353158120
## ASV5004     -0.1087614321
## ASV1483     -0.0556421227
## ASV9773     -0.1578516186
## ASV4059      0.0881385563
## ASV1193      0.1023377632
## ASV4610     -0.0344848908
## ASV0742     -0.0159817381
## ASV1502     -0.0536543373
## ASV0195      0.0023362217
## ASV1213      0.0045208430
## ASV1648     -0.1624671322
## ASV6984     -0.1879423388
## ASV0396     -0.0430524508
## ASV4297      0.0751454064
## ASV2622      0.1168289027
## ASV3512      0.2491925227
## ASV2411      0.1020034047
## ASV2291     -0.1857658432
## ASV0807      0.1982171092
## ASV1292      0.0768683654
## ASV1035      0.0812274806
## ASV0070      0.0438479414
## ASV0255     -0.0912719583
## ASV0057      0.0098396357
## ASV0077     -0.0327408434
## ASV0625      0.0183126215
## ASV2464      0.3056183286
## ASV1315      0.2285999171
## ASV2673      0.4224048993
## ASV2161      0.1662407265
## ASV0337     -0.0801760474
## ASV7680     -0.3465680642
## ASV0611      0.2303892554
## ASV3118     -0.2332239693
## ASV1284     -0.3406011570
## ASV0889      0.1117136460
## ASV4649     -0.0840830308
## ASV1108     -0.2709585392
## ASV0738      0.4208984224
## ASV0473     -0.0081221733
## ASV0598     -0.0641315351
## ASV0429      0.0221701857
## ASV1549      0.1515421355
## ASV1203      0.0719387093
## ASV4532      0.0157333648
## ASV0274      0.0120618127
## ASV0163     -0.0918662968
## ASV1298      0.2820986047
## ASV9424     -0.4855932468
## ASV0412      0.1115698794
## ASV0284     -0.0363146611
## ASV0620     -0.1463983030
## ASV0153     -0.1945967437
## ASV0498      0.0019756543
## ASV0097      0.0857647374
## ASV0104     -0.2075907930
## ASV1282      0.0328112600
## ASV3883      0.0093734017
## ASV0801      0.1381658669
## ASV1611     -0.2656601396
## ASV0227     -0.1003476213
## ASV0833      0.0548850636
## ASV0718      0.4125962114
## ASV1139     -0.0701131801
## ASV0766     -0.1005284643
## ASV2091      0.1026260585
## ASV1238     -0.3274436018
## ASV9193     -0.0957254326
## ASV0290      0.0092153763
## ASV0231      0.0557236645
## ASV0185      0.2044127204
## ASV2330     -0.0074506138
## ASV3119     -0.2240893921
## ASV2368     -0.2330046521
## ASV0122     -0.0220710905
## ASV1044      0.3709976315
## ASV0160     -0.0117286671
## ASV0326     -0.0146104445
## ASV1388      0.2174449925
## ASV0792      0.0855975222
## ASV0036     -0.0381771972
## ASV2125      0.0129555094
## ASV1075      0.0553514601
## ASV0390      0.3025648651
## ASV3790     -0.2146192050
## ASV1535     -0.1164613251
## ASV0263      0.1242076929
## ASV0675      0.3693168717
## ASV3348      0.0225346765
## ASV0058     -0.0788106865
## ASV4142      0.0762033818
## ASV0059     -0.0220491396
## ASV0013     -0.1195337831
## ASV0033     -0.0306496901
## ASV4354     -0.0916515437
## ASV0022     -0.0506910714
## ASV0134     -0.1581220216
## ASV0415      0.0634032113
## ASV10103    -0.3726225002
## ASV1613      0.0442617843
## ASV0135      0.0692920460
## ASV0469     -0.2132659683
## ASV0471      0.2041529571
## ASV0451     -0.1278303661
## ASV0747      0.0849129460
## ASV1314     -0.2331897668
## ASV0425     -0.1233524025
## ASV0559     -0.1620371045
## ASV0148      0.0259006315
## ASV0129      0.2047185320
## ASV1072     -0.0184568775
## ASV2390     -0.1008906899
## ASV0548      0.1414431178
## ASV0168     -0.0622076855
## ASV0066     -0.0014703429
## ASV0468     -0.1213015500
## ASV0172      0.0586004565
## ASV0236      0.0565346957
## ASV0250      0.2988950266
## ASV0338      0.0809565749
## ASV0450     -0.0495410039
## ASV0377      0.0727920138
## ASV1022      0.1155437965
## ASV6174      0.0170303510
## ASV0786     -0.1202076098
## ASV0053     -0.0859783218
## ASV0697     -0.1170138922
## ASV0785      0.1770971623
## ASV1967     -0.0514724126
## ASV0385     -0.0352645544
## ASV0295      0.1061706781
## ASV0072     -0.0188276927
## ASV0157      0.1418458552
## ASV0501      0.0543780097
## ASV10729    -0.4524878122
## ASV1470     -0.1576626799
## ASV0050     -0.1195124341
## ASV0411     -0.1002204785
## ASV0549      0.1567515269
## ASV0184      0.0483558960
## ASV0705      0.0294787203
## ASV1715      0.0945674606
## ASV0603      0.1014432921
## ASV0826      0.1500421118
## ASV0034     -0.0191754037
## ASV0838     -0.0048367685
## ASV0614     -0.0469921414
## ASV0014     -0.0987169014
## ASV0585      0.0045041127
## ASV0016     -0.1087915026
## ASV5394      0.0033409768
## ASV0666      0.0341515952
## ASV2085     -0.2668839173
## ASV0003     -0.0721238135
## ASV0346      0.0877723199
## ASV0267     -0.0426398777
## ASV0353      0.1144339348
## ASV2419     -0.0285795561
## ASV0447      0.0842404746
## ASV0654      0.1308031399
## ASV0151      0.0887824895
## ASV0065     -0.0542880277
## ASV0527      0.0554577115
## ASV4055     -0.2895307992
## ASV0166      0.0054297638
## ASV0417      0.0498074239
## ASV0078     -0.0217237860
## ASV0322      0.0184425021
## ASV0156     -0.1753951075
## ASV0648     -0.5480688086
## ASV0407     -0.0410408534
## ASV2030     -0.1416447423
## ASV0300      0.0275618093
## ASV1150     -0.0425521929
## ASV0958      0.2621018870
## ASV0216     -0.0918757420
## ASV0446      0.1939395856
## ASV0367     -0.1308744776
## ASV0200     -0.0202338668
## ASV0334     -0.0506410950
## ASV1311      0.0466802919
## ASV0458     -0.0621099617
## ASV1371     -0.0163789171
## ASV0418     -0.0400322086
## ASV0004      0.0035527939
## ASV1943      0.2105031320
## ASV1495     -0.1794426238
## ASV0901     -0.2108253189
## ASV0628     -0.0711952733
## ASV0400      0.0107112974
## ASV0116     -0.0607881092
## ASV0788      0.7681824450
## ASV0117      0.0130025534
## ASV3137      0.2311155280
## ASV0001      0.0069320148
## ASV1651      0.0562924451
## ASV1692      0.4811199270
## ASV0660     -0.0975325917
## ASV0508     -0.0744721709
## ASV1660     -0.0305645070
## ASV0233      0.0922846133
## ASV1343     -0.3296359431
## ASV0209     -0.0003868909
## ASV0193      0.0164955781
## ASV0357      0.0154987897
## ASV0198      0.0805360734
## ASV0007      0.0057122784
## ASV1772      0.5842968064
## ASV0009      0.0088244961
## ASV0006     -0.0033947085
## ASV0011     -0.0568832941
## ASV0015     -0.0112903315
## ASV0017     -0.0073536256
## ASV0235     -0.1364127420
## ASV0382     -0.0278614952
## ASV2357      0.1553479629
## ASV0567     -0.0166795052
## ASV0165      0.0245863280
## ASV0005      0.0086612566
## ASV0384      0.0892177682
## ASV0002      0.0124806797
## ASV3017      0.1303881548
## ASV0091     -0.0465345072
## ASV0186     -0.0385597659
## ASV0370      0.1289064907
## ASV0018      0.0249925569
## ASV1377      0.3724281175
## ASV0019      0.0322763236
## ASV0023     -0.0117402879
## ASV2194      0.0682218127
## ASV1155      0.1254270270
## ASV0510     -0.0656299358
## ASV2371     -0.0388672503
## ASV0024     -0.0151124288
## ASV2452      0.0446909007
## ASV2332     -0.0443995105
## ASV2591      0.2749063497
## ASV0521      0.1277422969
## ASV5542      0.0488911643
## ASV0336     -0.0375676667
## ASV10102     0.1120600397
## ASV16823    -0.0571882271
## ASV3104      0.3158167702
## ASV0781      0.2350119483
## ASV10899     0.1324174224
## ASV11222    -0.1000570316
## ASV11327    -0.0900704864
## ASV12458    -0.1002243141
## ASV1636     -0.0151378593
## ASV1890     -0.0332609932
## ASV2898      0.2039353046
## ASV8328      0.2406756749
## ASV0709     -0.2187717344
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## ASV2435     -0.0041539202
## ASV6822     -0.1937388856
## ASV12605    -0.3784556663
## ASV0286     -0.1329463531
## ASV0074     -0.0779901406
## ASV2485     -0.0946759819
## ASV1233     -0.5214656342
## ASV0356     -0.1084268217
## ASV2918     -0.2729912739
## ASV1427     -0.1679404815
## ASV1409      0.0813307242
## ASV0770     -0.1202093695
## ASV1403     -0.1569668903
## ASV0314      0.0938741138
## ASV0187      0.0476170696
## ASV0313      0.1003301367
## ASV1087      0.1989419311
## ASV1970      0.0212993801
## ASV0754      0.4067883100
## ASV3775     -0.1095950033
## ASV0132     -0.0255283570
## ASV2329     -0.0614842712
## ASV0561     -0.1808162639
## ASV0130     -0.0626227105
## ASV0226     -0.0070530922
## ASV12648    -0.2344604069
## ASV0204     -0.0006228678
## ASV0767     -0.3566546724
## ASV0335      0.0114535916
## ASV5901     -0.0255887461
## ASV0596      0.0042876241
## ASV9271      0.0910807369
## ASV0904      0.1655626963
## ASV15270    -0.0149605307
## ASV0990     -0.1026491247
## ASV0155     -0.1023483383
## ASV0086     -0.0674630355
## ASV2581      0.1347537701
## ASV1579     -0.1570611337
## ASV7730      0.1274894395
## ASV0897      0.1121293733
## ASV1975      0.4060080649

stats:glm

1000

library(stats)

logreg_1000 <- stats::glm(as.factor(Clade) ~ . ,
                          data = lr_clr_df_1000[,-1],
                          family = "binomial")
summary(logreg_1000)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_df_1000[, -1])
## 
## Coefficients: (765 not defined because of singularities)
##               Estimate Std. Error    z value Pr(>|z|)    
## (Intercept) -1.288e+34  8.363e+18 -1.540e+15   <2e-16 ***
## ASV1236      1.024e+38  4.426e+22  2.314e+15   <2e-16 ***
## ASV0421      7.110e+37  1.895e+21  3.752e+16   <2e-16 ***
## ASV0691     -1.214e+39  1.057e+23 -1.148e+16   <2e-16 ***
## ASV0899      2.877e+37  2.571e+22  1.119e+15   <2e-16 ***
## ASV1004      3.517e+38  4.225e+22  8.324e+15   <2e-16 ***
## ASV1041      1.338e+38  3.947e+22  3.390e+15   <2e-16 ***
## ASV1058      2.498e+38  3.593e+22  6.952e+15   <2e-16 ***
## ASV12542    -4.340e+37  1.551e+23 -2.798e+14   <2e-16 ***
## ASV1294      2.494e+38  2.047e+22  1.218e+16   <2e-16 ***
## ASV13113     8.339e+36  5.073e+20  1.644e+16   <2e-16 ***
## ASV1318      2.471e+37  3.732e+21  6.619e+15   <2e-16 ***
## ASV2269      5.895e+39  3.584e+23  1.645e+16   <2e-16 ***
## ASV2542     -4.536e+37  3.407e+21 -1.331e+16   <2e-16 ***
## ASV2660     -4.874e+38  1.161e+23 -4.200e+15   <2e-16 ***
## ASV2737     -5.395e+38  1.727e+23 -3.125e+15   <2e-16 ***
## ASV2840      1.762e+37  1.291e+22  1.365e+15   <2e-16 ***
## ASV3053      2.135e+39  1.677e+24  1.273e+15   <2e-16 ***
## ASV3077     -6.557e+38  9.289e+22 -7.059e+15   <2e-16 ***
## ASV3134     -1.019e+37  7.464e+20 -1.366e+16   <2e-16 ***
## ASV3140     -2.041e+38  1.943e+22 -1.050e+16   <2e-16 ***
## ASV3579     -2.615e+36  1.838e+21 -1.423e+15   <2e-16 ***
## ASV6119             NA         NA         NA       NA    
## ASV7557             NA         NA         NA       NA    
## ASV8422             NA         NA         NA       NA    
## ASV1086             NA         NA         NA       NA    
## ASV1310     -2.838e+38  1.477e+22 -1.922e+16   <2e-16 ***
## ASV15750     1.277e+38  4.382e+22  2.914e+15   <2e-16 ***
## ASV16905            NA         NA         NA       NA    
## ASV2033      2.173e+38  8.651e+21  2.512e+16   <2e-16 ***
## ASV2089             NA         NA         NA       NA    
## ASV2127      1.934e+37  1.415e+22  1.367e+15   <2e-16 ***
## ASV2725     -4.149e+37  2.119e+22 -1.958e+15   <2e-16 ***
## ASV2804             NA         NA         NA       NA    
## ASV3075     -1.411e+38  6.252e+21 -2.256e+16   <2e-16 ***
## ASV3327      3.796e+37  1.624e+22  2.338e+15   <2e-16 ***
## ASV3342      8.216e+37  4.341e+21  1.893e+16   <2e-16 ***
## ASV3532      1.945e+38  2.131e+22  9.129e+15   <2e-16 ***
## ASV3600     -2.793e+37  9.223e+21 -3.028e+15   <2e-16 ***
## ASV4013     -4.767e+38  1.679e+23 -2.839e+15   <2e-16 ***
## ASV4136      1.909e+36  6.303e+22  3.029e+13   <2e-16 ***
## ASV4195             NA         NA         NA       NA    
## ASV4407             NA         NA         NA       NA    
## ASV4717             NA         NA         NA       NA    
## ASV6794             NA         NA         NA       NA    
## ASV8324             NA         NA         NA       NA    
## ASV8981      6.958e+37  3.856e+21  1.805e+16   <2e-16 ***
## ASV9859     -5.776e+37  4.555e+21 -1.268e+16   <2e-16 ***
## ASV0936     -2.450e+38  1.675e+22 -1.463e+16   <2e-16 ***
## ASV12683            NA         NA         NA       NA    
## ASV1293      3.468e+37  6.409e+21  5.412e+15   <2e-16 ***
## ASV13055            NA         NA         NA       NA    
## ASV17063            NA         NA         NA       NA    
## ASV2228             NA         NA         NA       NA    
## ASV2769      1.648e+37  1.082e+23  1.523e+14   <2e-16 ***
## ASV2803     -6.102e+38  2.216e+22 -2.753e+16   <2e-16 ***
## ASV2896     -1.307e+36  6.667e+20 -1.960e+15   <2e-16 ***
## ASV3062             NA         NA         NA       NA    
## ASV3107      4.930e+36  6.459e+20  7.632e+15   <2e-16 ***
## ASV3265      2.195e+38  2.259e+22  9.714e+15   <2e-16 ***
## ASV3666             NA         NA         NA       NA    
## ASV4497      7.858e+38  7.320e+22  1.073e+16   <2e-16 ***
## ASV6914             NA         NA         NA       NA    
## ASV0576      1.416e+38  1.171e+22  1.209e+16   <2e-16 ***
## ASV0673      6.569e+37  3.161e+22  2.078e+15   <2e-16 ***
## ASV0772     -9.348e+37  2.127e+22 -4.395e+15   <2e-16 ***
## ASV0862      9.086e+38  6.182e+22  1.470e+16   <2e-16 ***
## ASV0898             NA         NA         NA       NA    
## ASV0910     -8.264e+36  1.216e+21 -6.798e+15   <2e-16 ***
## ASV0964             NA         NA         NA       NA    
## ASV10059    -2.008e+37  9.305e+20 -2.158e+16   <2e-16 ***
## ASV10263            NA         NA         NA       NA    
## ASV1088     -1.309e+38  5.357e+21 -2.443e+16   <2e-16 ***
## ASV1101             NA         NA         NA       NA    
## ASV1183     -4.149e+37  2.163e+21 -1.919e+16   <2e-16 ***
## ASV11956            NA         NA         NA       NA    
## ASV12774            NA         NA         NA       NA    
## ASV1321             NA         NA         NA       NA    
## ASV13793            NA         NA         NA       NA    
## ASV14482            NA         NA         NA       NA    
## ASV15483            NA         NA         NA       NA    
## ASV2062             NA         NA         NA       NA    
## ASV2132      1.803e+36  5.881e+20  3.065e+15   <2e-16 ***
## ASV2413             NA         NA         NA       NA    
## ASV2490             NA         NA         NA       NA    
## ASV2594      3.563e+37  1.596e+21  2.232e+16   <2e-16 ***
## ASV2822             NA         NA         NA       NA    
## ASV2863             NA         NA         NA       NA    
## ASV2910             NA         NA         NA       NA    
## ASV2980     -9.393e+38  6.143e+22 -1.529e+16   <2e-16 ***
## ASV3307             NA         NA         NA       NA    
## ASV3474             NA         NA         NA       NA    
## ASV3502      6.558e+37  5.077e+21  1.292e+16   <2e-16 ***
## ASV4236             NA         NA         NA       NA    
## ASV4842             NA         NA         NA       NA    
## ASV4894             NA         NA         NA       NA    
## ASV5290             NA         NA         NA       NA    
## ASV5501     -1.991e+38  4.168e+22 -4.777e+15   <2e-16 ***
## ASV5795             NA         NA         NA       NA    
## ASV5987             NA         NA         NA       NA    
## ASV6267             NA         NA         NA       NA    
## ASV6862             NA         NA         NA       NA    
## ASV7145             NA         NA         NA       NA    
## ASV7673             NA         NA         NA       NA    
## ASV7789             NA         NA         NA       NA    
## ASV7809             NA         NA         NA       NA    
## ASV8002             NA         NA         NA       NA    
## ASV8205      5.085e+37  2.745e+21  1.853e+16   <2e-16 ***
## ASV9155             NA         NA         NA       NA    
## ASV9221     -5.699e+37  5.216e+21 -1.093e+16   <2e-16 ***
## ASV9311             NA         NA         NA       NA    
## ASV9557             NA         NA         NA       NA    
## ASV9936             NA         NA         NA       NA    
## ASV1445     -3.061e+37  1.052e+22 -2.910e+15   <2e-16 ***
## ASV4232      3.577e+36  4.082e+20  8.763e+15   <2e-16 ***
## ASV6479     -2.869e+37  1.937e+21 -1.481e+16   <2e-16 ***
## ASV0142      1.095e+38  1.157e+22  9.463e+15   <2e-16 ***
## ASV0378     -1.451e+38  7.674e+21 -1.891e+16   <2e-16 ***
## ASV1122     -3.809e+37  1.168e+22 -3.260e+15   <2e-16 ***
## ASV0123      3.023e+37  1.271e+22  2.379e+15   <2e-16 ***
## ASV2064      2.134e+38  1.434e+22  1.488e+16   <2e-16 ***
## ASV4459     -1.091e+38  5.030e+21 -2.170e+16   <2e-16 ***
## ASV0448      5.514e+36  4.265e+20  1.293e+16   <2e-16 ***
## ASV0397      2.975e+37  7.627e+20  3.901e+16   <2e-16 ***
## ASV0485      2.182e+37  1.937e+21  1.126e+16   <2e-16 ***
## ASV1566             NA         NA         NA       NA    
## ASV1365     -1.280e+38  8.600e+21 -1.489e+16   <2e-16 ***
## ASV1065      9.217e+37  7.106e+21  1.297e+16   <2e-16 ***
## ASV0722      5.134e+36  3.956e+21  1.298e+15   <2e-16 ***
## ASV12660            NA         NA         NA       NA    
## ASV0223      8.402e+36  4.058e+20  2.071e+16   <2e-16 ***
## ASV0229      4.373e+37  9.283e+21  4.711e+15   <2e-16 ***
## ASV0877     -8.335e+36  4.455e+21 -1.871e+15   <2e-16 ***
## ASV0983     -7.332e+37  4.541e+21 -1.615e+16   <2e-16 ***
## ASV0626             NA         NA         NA       NA    
## ASV4146     -9.667e+37  7.302e+21 -1.324e+16   <2e-16 ***
## ASV4175      2.547e+37  7.547e+21  3.375e+15   <2e-16 ***
## ASV2082      1.194e+38  1.287e+22  9.275e+15   <2e-16 ***
## ASV2272     -4.011e+36  9.680e+20 -4.143e+15   <2e-16 ***
## ASV2245     -8.718e+37  7.061e+21 -1.235e+16   <2e-16 ***
## ASV0590             NA         NA         NA       NA    
## ASV0217      1.332e+37  5.036e+20  2.644e+16   <2e-16 ***
## ASV0416      9.422e+37  4.921e+21  1.915e+16   <2e-16 ***
## ASV1056     -6.089e+36  1.899e+21 -3.206e+15   <2e-16 ***
## ASV7777     -2.828e+35  3.524e+19 -8.027e+15   <2e-16 ***
## ASV0455      1.360e+37  9.123e+20  1.491e+16   <2e-16 ***
## ASV0604             NA         NA         NA       NA    
## ASV6100      2.054e+36  2.570e+20  7.994e+15   <2e-16 ***
## ASV11359            NA         NA         NA       NA    
## ASV6604     -1.088e+37  6.176e+20 -1.762e+16   <2e-16 ***
## ASV5004     -2.397e+37  5.634e+21 -4.255e+15   <2e-16 ***
## ASV1483      2.367e+37  4.211e+21  5.621e+15   <2e-16 ***
## ASV9773     -3.750e+34  2.983e+18 -1.257e+16   <2e-16 ***
## ASV4059      2.837e+37  3.643e+21  7.787e+15   <2e-16 ***
## ASV1193      2.533e+37  1.265e+21  2.003e+16   <2e-16 ***
## ASV4610             NA         NA         NA       NA    
## ASV0742             NA         NA         NA       NA    
## ASV1502     -7.507e+37  5.530e+21 -1.357e+16   <2e-16 ***
## ASV0195      1.767e+37  1.937e+21  9.122e+15   <2e-16 ***
## ASV1213     -5.878e+37  5.089e+21 -1.155e+16   <2e-16 ***
## ASV1648     -7.475e+36  2.926e+21 -2.555e+15   <2e-16 ***
## ASV6984     -4.045e+37  1.520e+21 -2.661e+16   <2e-16 ***
## ASV0396      1.781e+35  7.231e+20  2.463e+14   <2e-16 ***
## ASV4297             NA         NA         NA       NA    
## ASV2622     -2.489e+37  1.719e+21 -1.448e+16   <2e-16 ***
## ASV3512     -2.045e+36  4.062e+20 -5.036e+15   <2e-16 ***
## ASV2411             NA         NA         NA       NA    
## ASV2291             NA         NA         NA       NA    
## ASV0807     -2.261e+37  1.502e+21 -1.505e+16   <2e-16 ***
## ASV1292     -1.988e+37  1.213e+21 -1.639e+16   <2e-16 ***
## ASV1035             NA         NA         NA       NA    
## ASV0070      1.059e+35  1.539e+19  6.882e+15   <2e-16 ***
## ASV0255      4.556e+36  3.898e+20  1.169e+16   <2e-16 ***
## ASV0057      4.126e+36  2.372e+20  1.739e+16   <2e-16 ***
## ASV0077     -5.617e+35  1.191e+20 -4.716e+15   <2e-16 ***
## ASV0625      3.369e+37  1.629e+21  2.068e+16   <2e-16 ***
## ASV2464             NA         NA         NA       NA    
## ASV1315     -1.959e+37  1.566e+21 -1.251e+16   <2e-16 ***
## ASV2673     -6.098e+36  5.105e+20 -1.195e+16   <2e-16 ***
## ASV2161      2.883e+37  1.812e+21  1.591e+16   <2e-16 ***
## ASV0337     -5.602e+36  3.933e+20 -1.424e+16   <2e-16 ***
## ASV7680     -5.037e+37  2.606e+21 -1.933e+16   <2e-16 ***
## ASV0611     -4.503e+36  4.314e+20 -1.044e+16   <2e-16 ***
## ASV3118     -1.223e+38  1.074e+22 -1.138e+16   <2e-16 ***
## ASV1284      3.351e+36  2.997e+20  1.118e+16   <2e-16 ***
## ASV0889             NA         NA         NA       NA    
## ASV4649     -4.528e+37  2.587e+21 -1.750e+16   <2e-16 ***
## ASV1108      7.837e+36  2.367e+21  3.311e+15   <2e-16 ***
## ASV0738     -7.993e+36  5.564e+20 -1.436e+16   <2e-16 ***
## ASV0473      1.898e+36  1.918e+20  9.896e+15   <2e-16 ***
## ASV0598             NA         NA         NA       NA    
## ASV0429     -3.054e+37  2.478e+21 -1.233e+16   <2e-16 ***
## ASV1549     -1.529e+36  2.122e+20 -7.204e+15   <2e-16 ***
## ASV1203     -1.640e+37  1.353e+21 -1.212e+16   <2e-16 ***
## ASV4532      6.531e+36  4.831e+20  1.352e+16   <2e-16 ***
## ASV0274      1.609e+37  6.816e+20  2.360e+16   <2e-16 ***
## ASV0163      1.761e+37  1.836e+21  9.591e+15   <2e-16 ***
## ASV1298      1.728e+35  8.059e+20  2.145e+14   <2e-16 ***
## ASV9424      7.313e+37  4.239e+21  1.725e+16   <2e-16 ***
## ASV0412     -6.623e+37  8.254e+21 -8.024e+15   <2e-16 ***
## ASV0284      3.522e+37  1.627e+21  2.164e+16   <2e-16 ***
## ASV0620             NA         NA         NA       NA    
## ASV0153     -3.630e+36  4.115e+20 -8.822e+15   <2e-16 ***
## ASV0498     -1.296e+37  1.091e+21 -1.189e+16   <2e-16 ***
## ASV0097      2.914e+36  4.176e+20  6.976e+15   <2e-16 ***
## ASV0104     -9.662e+36  6.073e+20 -1.591e+16   <2e-16 ***
## ASV1282      5.958e+37  3.199e+21  1.862e+16   <2e-16 ***
## ASV3883     -2.974e+37  1.546e+21 -1.924e+16   <2e-16 ***
## ASV0801      7.240e+37  4.005e+21  1.808e+16   <2e-16 ***
## ASV1611     -4.028e+37  2.238e+21 -1.800e+16   <2e-16 ***
## ASV0227     -1.018e+37  7.162e+20 -1.422e+16   <2e-16 ***
## ASV0833             NA         NA         NA       NA    
## ASV0718     -2.274e+37  6.617e+20 -3.437e+16   <2e-16 ***
## ASV1139             NA         NA         NA       NA    
## ASV0766      1.680e+37  3.541e+21  4.745e+15   <2e-16 ***
## ASV2091      2.604e+37  1.827e+21  1.425e+16   <2e-16 ***
## ASV1238      5.942e+37  4.569e+21  1.301e+16   <2e-16 ***
## ASV9193             NA         NA         NA       NA    
## ASV0290      3.269e+37  1.295e+21  2.524e+16   <2e-16 ***
## ASV0231     -1.859e+37  1.643e+21 -1.131e+16   <2e-16 ***
## ASV0185     -9.323e+35  1.175e+20 -7.938e+15   <2e-16 ***
## ASV2330             NA         NA         NA       NA    
## ASV3119     -1.786e+35  6.412e+19 -2.786e+15   <2e-16 ***
## ASV2368      1.453e+36  2.313e+20  6.284e+15   <2e-16 ***
## ASV0122     -2.332e+36  2.666e+20 -8.749e+15   <2e-16 ***
## ASV1044      2.267e+36  4.767e+20  4.755e+15   <2e-16 ***
## ASV0160     -1.036e+36  1.387e+20 -7.467e+15   <2e-16 ***
## ASV0326     -4.935e+34  8.651e+18 -5.705e+15   <2e-16 ***
## ASV1388      1.098e+37  5.467e+20  2.008e+16   <2e-16 ***
## ASV0792             NA         NA         NA       NA    
## ASV0036      2.466e+36  2.958e+20  8.337e+15   <2e-16 ***
## ASV2125     -3.381e+37  2.364e+20 -1.430e+17   <2e-16 ***
## ASV1075      3.328e+35  5.454e+19  6.103e+15   <2e-16 ***
## ASV0390      1.123e+36  1.404e+20  7.997e+15   <2e-16 ***
## ASV3790     -2.602e+35  1.913e+20 -1.360e+15   <2e-16 ***
## ASV1535      4.452e+36  5.559e+20  8.009e+15   <2e-16 ***
## ASV0263             NA         NA         NA       NA    
## ASV0675      1.084e+36  1.176e+20  9.213e+15   <2e-16 ***
## ASV3348     -3.341e+35  3.274e+20 -1.021e+15   <2e-16 ***
## ASV0058     -8.929e+35  9.675e+19 -9.228e+15   <2e-16 ***
## ASV4142             NA         NA         NA       NA    
## ASV0059      8.725e+35  8.087e+19  1.079e+16   <2e-16 ***
## ASV0013     -1.483e+36  1.227e+20 -1.209e+16   <2e-16 ***
## ASV0033      1.438e+36  5.005e+20  2.873e+15   <2e-16 ***
## ASV4354             NA         NA         NA       NA    
## ASV0022     -2.846e+36  1.822e+20 -1.562e+16   <2e-16 ***
## ASV0134     -2.484e+37  9.924e+20 -2.503e+16   <2e-16 ***
## ASV0415      3.102e+37  1.030e+21  3.013e+16   <2e-16 ***
## ASV10103            NA         NA         NA       NA    
## ASV1613     -9.886e+36  1.415e+21 -6.988e+15   <2e-16 ***
## ASV0135     -3.503e+35  4.439e+19 -7.893e+15   <2e-16 ***
## ASV0469             NA         NA         NA       NA    
## ASV0471     -1.199e+37  1.023e+21 -1.172e+16   <2e-16 ***
## ASV0451      6.160e+35  8.455e+19  7.286e+15   <2e-16 ***
## ASV0747      9.397e+36  7.406e+20  1.269e+16   <2e-16 ***
## ASV1314     -2.326e+35  2.861e+19 -8.129e+15   <2e-16 ***
## ASV0425             NA         NA         NA       NA    
## ASV0559      4.886e+37  1.982e+21  2.465e+16   <2e-16 ***
## ASV0148      8.356e+34  1.598e+19  5.228e+15   <2e-16 ***
## ASV0129      5.785e+35  4.789e+19  1.208e+16   <2e-16 ***
## ASV1072      1.438e+36  1.612e+20  8.924e+15   <2e-16 ***
## ASV2390             NA         NA         NA       NA    
## ASV0548      8.543e+36  7.800e+20  1.095e+16   <2e-16 ***
## ASV0168      8.974e+34  1.148e+19  7.819e+15   <2e-16 ***
## ASV0066      1.351e+33  8.744e+17  1.545e+15   <2e-16 ***
## ASV0468     -8.917e+33  5.606e+18 -1.591e+15   <2e-16 ***
## ASV0172      1.147e+36  9.969e+19  1.151e+16   <2e-16 ***
## ASV0236      2.468e+37  4.424e+20  5.578e+16   <2e-16 ***
## ASV0250      1.872e+35  2.488e+19  7.527e+15   <2e-16 ***
## ASV0338     -4.599e+36  4.192e+20 -1.097e+16   <2e-16 ***
## ASV0450     -2.960e+35  4.399e+19 -6.730e+15   <2e-16 ***
## ASV0377             NA         NA         NA       NA    
## ASV1022      1.599e+35  1.427e+19  1.120e+16   <2e-16 ***
## ASV6174             NA         NA         NA       NA    
## ASV0786             NA         NA         NA       NA    
## ASV0053     -5.722e+35  7.946e+19 -7.200e+15   <2e-16 ***
## ASV0697     -1.742e+36  1.421e+20 -1.226e+16   <2e-16 ***
## ASV0785     -7.239e+35  9.908e+19 -7.307e+15   <2e-16 ***
## ASV1967     -1.044e+35  1.347e+19 -7.748e+15   <2e-16 ***
## ASV0385     -3.900e+36  5.089e+20 -7.662e+15   <2e-16 ***
## ASV0295     -1.183e+35  1.142e+19 -1.036e+16   <2e-16 ***
## ASV0072     -1.392e+35  1.934e+19 -7.198e+15   <2e-16 ***
## ASV0157      1.076e+36  1.069e+20  1.006e+16   <2e-16 ***
## ASV0501      6.524e+36  5.663e+20  1.152e+16   <2e-16 ***
## ASV10729     7.784e+36  4.460e+20  1.745e+16   <2e-16 ***
## ASV1470             NA         NA         NA       NA    
## ASV0050      1.041e+37  4.694e+20  2.218e+16   <2e-16 ***
## ASV0411     -1.631e+35  2.094e+19 -7.790e+15   <2e-16 ***
## ASV0549     -3.438e+36  4.081e+20 -8.426e+15   <2e-16 ***
## ASV0184      1.117e+34  6.522e+18  1.713e+15   <2e-16 ***
## ASV0705      9.729e+35  1.192e+20  8.162e+15   <2e-16 ***
## ASV1715      3.131e+36  4.839e+20  6.469e+15   <2e-16 ***
## ASV0603      5.862e+34  1.673e+19  3.503e+15   <2e-16 ***
## ASV0826     -2.826e+37  8.451e+20 -3.344e+16   <2e-16 ***
## ASV0034      1.855e+35  2.101e+19  8.827e+15   <2e-16 ***
## ASV0838      1.286e+37  1.051e+21  1.224e+16   <2e-16 ***
## ASV0614     -1.232e+36  1.062e+20 -1.160e+16   <2e-16 ***
## ASV0014     -1.937e+36  5.937e+20 -3.262e+15   <2e-16 ***
## ASV0585             NA         NA         NA       NA    
## ASV0016      1.934e+36  7.272e+20  2.660e+15   <2e-16 ***
## ASV5394      3.265e+35  1.180e+20  2.767e+15   <2e-16 ***
## ASV0666             NA         NA         NA       NA    
## ASV2085             NA         NA         NA       NA    
## ASV0003      1.679e+36  2.203e+20  7.623e+15   <2e-16 ***
## ASV0346      2.786e+36  5.059e+20  5.506e+15   <2e-16 ***
## ASV0267     -5.355e+36  5.906e+20 -9.068e+15   <2e-16 ***
## ASV0353     -1.281e+36  1.280e+20 -1.001e+16   <2e-16 ***
## ASV2419      1.590e+37  1.395e+21  1.139e+16   <2e-16 ***
## ASV0447             NA         NA         NA       NA    
## ASV0654             NA         NA         NA       NA    
## ASV0151      1.600e+36  2.598e+20  6.159e+15   <2e-16 ***
## ASV0065      2.256e+35  3.067e+19  7.356e+15   <2e-16 ***
## ASV0527      3.114e+36  9.700e+19  3.210e+16   <2e-16 ***
## ASV4055             NA         NA         NA       NA    
## ASV0166             NA         NA         NA       NA    
## ASV0417      4.866e+35  5.229e+19  9.306e+15   <2e-16 ***
## ASV0078     -5.905e+33  3.820e+18 -1.546e+15   <2e-16 ***
## ASV0322             NA         NA         NA       NA    
## ASV0156     -4.705e+34  1.548e+19 -3.040e+15   <2e-16 ***
## ASV0648             NA         NA         NA       NA    
## ASV0407     -7.655e+34  1.024e+19 -7.477e+15   <2e-16 ***
## ASV2030             NA         NA         NA       NA    
## ASV0300      3.354e+33  3.515e+18  9.541e+14   <2e-16 ***
## ASV1150     -2.182e+35  3.140e+19 -6.949e+15   <2e-16 ***
## ASV0958     -2.016e+37  6.862e+19 -2.938e+17   <2e-16 ***
## ASV0216             NA         NA         NA       NA    
## ASV0446      6.844e+34  8.616e+19  7.944e+14   <2e-16 ***
## ASV0367             NA         NA         NA       NA    
## ASV0200             NA         NA         NA       NA    
## ASV0334             NA         NA         NA       NA    
## ASV1311             NA         NA         NA       NA    
## ASV0458             NA         NA         NA       NA    
## ASV1371             NA         NA         NA       NA    
## ASV0418             NA         NA         NA       NA    
## ASV0004      4.799e+33  3.094e+18  1.551e+15   <2e-16 ***
## ASV1943             NA         NA         NA       NA    
## ASV1495             NA         NA         NA       NA    
## ASV0901             NA         NA         NA       NA    
## ASV0628             NA         NA         NA       NA    
## ASV0400             NA         NA         NA       NA    
## ASV0116             NA         NA         NA       NA    
## ASV0788             NA         NA         NA       NA    
## ASV0117             NA         NA         NA       NA    
## ASV3137             NA         NA         NA       NA    
## ASV0001             NA         NA         NA       NA    
## ASV1651             NA         NA         NA       NA    
## ASV1692             NA         NA         NA       NA    
## ASV0660             NA         NA         NA       NA    
## ASV0508             NA         NA         NA       NA    
## ASV1660             NA         NA         NA       NA    
## ASV0233             NA         NA         NA       NA    
## ASV1343             NA         NA         NA       NA    
## ASV0209             NA         NA         NA       NA    
## ASV0193             NA         NA         NA       NA    
## ASV0357             NA         NA         NA       NA    
## ASV0198             NA         NA         NA       NA    
## ASV0007             NA         NA         NA       NA    
## ASV1772             NA         NA         NA       NA    
## ASV0009             NA         NA         NA       NA    
## ASV0006             NA         NA         NA       NA    
## ASV0011             NA         NA         NA       NA    
## ASV0015             NA         NA         NA       NA    
## ASV0017             NA         NA         NA       NA    
## ASV0235             NA         NA         NA       NA    
## ASV0382             NA         NA         NA       NA    
## ASV2357             NA         NA         NA       NA    
## ASV0567             NA         NA         NA       NA    
## ASV0165             NA         NA         NA       NA    
## ASV0005             NA         NA         NA       NA    
## ASV0384             NA         NA         NA       NA    
## ASV0002             NA         NA         NA       NA    
## ASV3017             NA         NA         NA       NA    
## ASV0091             NA         NA         NA       NA    
## ASV0186             NA         NA         NA       NA    
## ASV0370             NA         NA         NA       NA    
## ASV0018             NA         NA         NA       NA    
## ASV1377             NA         NA         NA       NA    
## ASV0019             NA         NA         NA       NA    
## ASV0023             NA         NA         NA       NA    
## ASV2194             NA         NA         NA       NA    
## ASV1155             NA         NA         NA       NA    
## ASV0510             NA         NA         NA       NA    
## ASV2371             NA         NA         NA       NA    
## ASV0024             NA         NA         NA       NA    
## ASV2452             NA         NA         NA       NA    
## ASV2332             NA         NA         NA       NA    
## ASV2591             NA         NA         NA       NA    
## ASV0521             NA         NA         NA       NA    
## ASV5542             NA         NA         NA       NA    
## ASV0336             NA         NA         NA       NA    
## ASV10102            NA         NA         NA       NA    
## ASV16823            NA         NA         NA       NA    
## ASV3104             NA         NA         NA       NA    
## ASV0781             NA         NA         NA       NA    
## ASV10899            NA         NA         NA       NA    
## ASV11222            NA         NA         NA       NA    
## ASV11327            NA         NA         NA       NA    
## ASV12458            NA         NA         NA       NA    
## ASV1636             NA         NA         NA       NA    
## ASV1890             NA         NA         NA       NA    
## ASV2898             NA         NA         NA       NA    
## ASV8328             NA         NA         NA       NA    
## ASV0709             NA         NA         NA       NA    
## ASV0856             NA         NA         NA       NA    
## ASV0909             NA         NA         NA       NA    
## ASV0937             NA         NA         NA       NA    
## ASV11390            NA         NA         NA       NA    
## ASV11966            NA         NA         NA       NA    
## ASV12990            NA         NA         NA       NA    
## ASV14797            NA         NA         NA       NA    
## ASV14904            NA         NA         NA       NA    
## ASV15304            NA         NA         NA       NA    
## ASV16696            NA         NA         NA       NA    
## ASV1690             NA         NA         NA       NA    
## ASV2029             NA         NA         NA       NA    
## ASV2834             NA         NA         NA       NA    
## ASV4003             NA         NA         NA       NA    
## ASV4064             NA         NA         NA       NA    
## ASV4294             NA         NA         NA       NA    
## ASV4609             NA         NA         NA       NA    
## ASV6283             NA         NA         NA       NA    
## ASV6491             NA         NA         NA       NA    
## ASV7453             NA         NA         NA       NA    
## ASV7959             NA         NA         NA       NA    
## ASV8219             NA         NA         NA       NA    
## ASV8547             NA         NA         NA       NA    
## ASV9319             NA         NA         NA       NA    
## ASV9382             NA         NA         NA       NA    
## ASV11516            NA         NA         NA       NA    
## ASV14377            NA         NA         NA       NA    
## ASV1867             NA         NA         NA       NA    
## ASV1895             NA         NA         NA       NA    
## ASV3168             NA         NA         NA       NA    
## ASV4449             NA         NA         NA       NA    
## ASV6596             NA         NA         NA       NA    
## ASV7492             NA         NA         NA       NA    
## ASV9854             NA         NA         NA       NA    
## ASV6296             NA         NA         NA       NA    
## ASV4201             NA         NA         NA       NA    
## ASV0552             NA         NA         NA       NA    
## ASV3671             NA         NA         NA       NA    
## ASV3529             NA         NA         NA       NA    
## ASV1060             NA         NA         NA       NA    
## ASV0239             NA         NA         NA       NA    
## ASV5711             NA         NA         NA       NA    
## ASV4152             NA         NA         NA       NA    
## ASV1461             NA         NA         NA       NA    
## ASV2877             NA         NA         NA       NA    
## ASV0012             NA         NA         NA       NA    
## ASV9823             NA         NA         NA       NA    
## ASV0008             NA         NA         NA       NA    
## ASV7832             NA         NA         NA       NA    
## ASV1915             NA         NA         NA       NA    
## ASV0055             NA         NA         NA       NA    
## ASV0032             NA         NA         NA       NA    
## ASV2977             NA         NA         NA       NA    
## ASV0466             NA         NA         NA       NA    
## ASV3866             NA         NA         NA       NA    
## ASV0040             NA         NA         NA       NA    
## ASV0496             NA         NA         NA       NA    
## ASV0052             NA         NA         NA       NA    
## ASV3828      6.303e+33  5.110e+18  1.233e+15   <2e-16 ***
## ASV1930             NA         NA         NA       NA    
## ASV2126             NA         NA         NA       NA    
## ASV0793             NA         NA         NA       NA    
## ASV0299             NA         NA         NA       NA    
## ASV0208             NA         NA         NA       NA    
## ASV0511             NA         NA         NA       NA    
## ASV1123             NA         NA         NA       NA    
## ASV0099             NA         NA         NA       NA    
## ASV0752             NA         NA         NA       NA    
## ASV0883             NA         NA         NA       NA    
## ASV0683      1.498e+37  1.117e+21  1.341e+16   <2e-16 ***
## ASV4117             NA         NA         NA       NA    
## ASV2172             NA         NA         NA       NA    
## ASV0330             NA         NA         NA       NA    
## ASV0728             NA         NA         NA       NA    
## ASV0499             NA         NA         NA       NA    
## ASV0120             NA         NA         NA       NA    
## ASV1446             NA         NA         NA       NA    
## ASV17171            NA         NA         NA       NA    
## ASV0533             NA         NA         NA       NA    
## ASV2495             NA         NA         NA       NA    
## ASV5582             NA         NA         NA       NA    
## ASV1488             NA         NA         NA       NA    
## ASV0682             NA         NA         NA       NA    
## ASV0068             NA         NA         NA       NA    
## ASV1987             NA         NA         NA       NA    
## ASV0035             NA         NA         NA       NA    
## ASV7192             NA         NA         NA       NA    
## ASV0873             NA         NA         NA       NA    
## ASV4749             NA         NA         NA       NA    
## ASV2174             NA         NA         NA       NA    
## ASV1476             NA         NA         NA       NA    
## ASV0740             NA         NA         NA       NA    
## ASV0170             NA         NA         NA       NA    
## ASV2466             NA         NA         NA       NA    
## ASV1709             NA         NA         NA       NA    
## ASV6170             NA         NA         NA       NA    
## ASV3673             NA         NA         NA       NA    
## ASV1745             NA         NA         NA       NA    
## ASV0380             NA         NA         NA       NA    
## ASV0426             NA         NA         NA       NA    
## ASV0202             NA         NA         NA       NA    
## ASV6350             NA         NA         NA       NA    
## ASV0713             NA         NA         NA       NA    
## ASV1822             NA         NA         NA       NA    
## ASV4569             NA         NA         NA       NA    
## ASV0030             NA         NA         NA       NA    
## ASV0331             NA         NA         NA       NA    
## ASV2981             NA         NA         NA       NA    
## ASV0828             NA         NA         NA       NA    
## ASV2440             NA         NA         NA       NA    
## ASV3006             NA         NA         NA       NA    
## ASV3875             NA         NA         NA       NA    
## ASV4511             NA         NA         NA       NA    
## ASV4700             NA         NA         NA       NA    
## ASV5804             NA         NA         NA       NA    
## ASV6826             NA         NA         NA       NA    
## ASV7280             NA         NA         NA       NA    
## ASV7535             NA         NA         NA       NA    
## ASV0651             NA         NA         NA       NA    
## ASV0913             NA         NA         NA       NA    
## ASV10832            NA         NA         NA       NA    
## ASV1117             NA         NA         NA       NA    
## ASV11329            NA         NA         NA       NA    
## ASV13209            NA         NA         NA       NA    
## ASV1345             NA         NA         NA       NA    
## ASV1719             NA         NA         NA       NA    
## ASV1886             NA         NA         NA       NA    
## ASV2158             NA         NA         NA       NA    
## ASV2189             NA         NA         NA       NA    
## ASV2257             NA         NA         NA       NA    
## ASV2283             NA         NA         NA       NA    
## ASV2328             NA         NA         NA       NA    
## ASV2434             NA         NA         NA       NA    
## ASV2648             NA         NA         NA       NA    
## ASV2698             NA         NA         NA       NA    
## ASV2775             NA         NA         NA       NA    
## ASV3171             NA         NA         NA       NA    
## ASV3227             NA         NA         NA       NA    
## ASV3397             NA         NA         NA       NA    
## ASV3444             NA         NA         NA       NA    
## ASV3556             NA         NA         NA       NA    
## ASV3606             NA         NA         NA       NA    
## ASV4190             NA         NA         NA       NA    
## ASV4197             NA         NA         NA       NA    
## ASV4722             NA         NA         NA       NA    
## ASV4765             NA         NA         NA       NA    
## ASV4809             NA         NA         NA       NA    
## ASV4846             NA         NA         NA       NA    
## ASV4903             NA         NA         NA       NA    
## ASV4944             NA         NA         NA       NA    
## ASV5151             NA         NA         NA       NA    
## ASV5413             NA         NA         NA       NA    
## ASV5537             NA         NA         NA       NA    
## ASV5688             NA         NA         NA       NA    
## ASV5752             NA         NA         NA       NA    
## ASV6122             NA         NA         NA       NA    
## ASV6135             NA         NA         NA       NA    
## ASV6188             NA         NA         NA       NA    
## ASV6216             NA         NA         NA       NA    
## ASV6242             NA         NA         NA       NA    
## ASV6383             NA         NA         NA       NA    
## ASV6781             NA         NA         NA       NA    
## ASV6799             NA         NA         NA       NA    
## ASV7374             NA         NA         NA       NA    
## ASV7539             NA         NA         NA       NA    
## ASV8591             NA         NA         NA       NA    
## ASV8637             NA         NA         NA       NA    
## ASV12796            NA         NA         NA       NA    
## ASV1934             NA         NA         NA       NA    
## ASV22549            NA         NA         NA       NA    
## ASV29857            NA         NA         NA       NA    
## ASV3215             NA         NA         NA       NA    
## ASV3236             NA         NA         NA       NA    
## ASV3954             NA         NA         NA       NA    
## ASV4850             NA         NA         NA       NA    
## ASV5225             NA         NA         NA       NA    
## ASV5532             NA         NA         NA       NA    
## ASV7258             NA         NA         NA       NA    
## ASV9474             NA         NA         NA       NA    
## ASV11857            NA         NA         NA       NA    
## ASV1202             NA         NA         NA       NA    
## ASV14742            NA         NA         NA       NA    
## ASV16652            NA         NA         NA       NA    
## ASV2019             NA         NA         NA       NA    
## ASV2410             NA         NA         NA       NA    
## ASV2718             NA         NA         NA       NA    
## ASV2738             NA         NA         NA       NA    
## ASV2876             NA         NA         NA       NA    
## ASV3177             NA         NA         NA       NA    
## ASV4367             NA         NA         NA       NA    
## ASV4635             NA         NA         NA       NA    
## ASV4896             NA         NA         NA       NA    
## ASV4907             NA         NA         NA       NA    
## ASV5230             NA         NA         NA       NA    
## ASV6509             NA         NA         NA       NA    
## ASV7376             NA         NA         NA       NA    
## ASV8163             NA         NA         NA       NA    
## ASV8195             NA         NA         NA       NA    
## ASV8923             NA         NA         NA       NA    
## ASV9666             NA         NA         NA       NA    
## ASV1482             NA         NA         NA       NA    
## ASV2726             NA         NA         NA       NA    
## ASV3281             NA         NA         NA       NA    
## ASV4235             NA         NA         NA       NA    
## ASV4808             NA         NA         NA       NA    
## ASV4861             NA         NA         NA       NA    
## ASV5276             NA         NA         NA       NA    
## ASV5837             NA         NA         NA       NA    
## ASV7098             NA         NA         NA       NA    
## ASV8451             NA         NA         NA       NA    
## ASV8694             NA         NA         NA       NA    
## ASV0905             NA         NA         NA       NA    
## ASV2900             NA         NA         NA       NA    
## ASV3963             NA         NA         NA       NA    
## ASV0041             NA         NA         NA       NA    
## ASV1865             NA         NA         NA       NA    
## ASV1140             NA         NA         NA       NA    
## ASV1179             NA         NA         NA       NA    
## ASV0279             NA         NA         NA       NA    
## ASV0043             NA         NA         NA       NA    
## ASV2097             NA         NA         NA       NA    
## ASV0309             NA         NA         NA       NA    
## ASV0607             NA         NA         NA       NA    
## ASV0025             NA         NA         NA       NA    
## ASV2284             NA         NA         NA       NA    
## ASV0556             NA         NA         NA       NA    
## ASV5040             NA         NA         NA       NA    
## ASV2924             NA         NA         NA       NA    
## ASV1331             NA         NA         NA       NA    
## ASV0506             NA         NA         NA       NA    
## ASV1514             NA         NA         NA       NA    
## ASV2144             NA         NA         NA       NA    
## ASV2265             NA         NA         NA       NA    
## ASV5156             NA         NA         NA       NA    
## ASV5534             NA         NA         NA       NA    
## ASV5747             NA         NA         NA       NA    
## ASV6657             NA         NA         NA       NA    
## ASV0658             NA         NA         NA       NA    
## ASV0716             NA         NA         NA       NA    
## ASV1657             NA         NA         NA       NA    
## ASV1885             NA         NA         NA       NA    
## ASV2333             NA         NA         NA       NA    
## ASV3375             NA         NA         NA       NA    
## ASV4317             NA         NA         NA       NA    
## ASV9599             NA         NA         NA       NA    
## ASV0175             NA         NA         NA       NA    
## ASV1032             NA         NA         NA       NA    
## ASV1235             NA         NA         NA       NA    
## ASV1262             NA         NA         NA       NA    
## ASV1320             NA         NA         NA       NA    
## ASV13797            NA         NA         NA       NA    
## ASV1491             NA         NA         NA       NA    
## ASV15014            NA         NA         NA       NA    
## ASV1510             NA         NA         NA       NA    
## ASV1551             NA         NA         NA       NA    
## ASV1919             NA         NA         NA       NA    
## ASV2114      1.923e+37  1.314e+21  1.463e+16   <2e-16 ***
## ASV21486            NA         NA         NA       NA    
## ASV2448             NA         NA         NA       NA    
## ASV2589             NA         NA         NA       NA    
## ASV2608             NA         NA         NA       NA    
## ASV2786             NA         NA         NA       NA    
## ASV2827             NA         NA         NA       NA    
## ASV2872             NA         NA         NA       NA    
## ASV3125             NA         NA         NA       NA    
## ASV3247             NA         NA         NA       NA    
## ASV3451             NA         NA         NA       NA    
## ASV3465             NA         NA         NA       NA    
## ASV3809             NA         NA         NA       NA    
## ASV4006             NA         NA         NA       NA    
## ASV4046             NA         NA         NA       NA    
## ASV4938             NA         NA         NA       NA    
## ASV5435             NA         NA         NA       NA    
## ASV5605             NA         NA         NA       NA    
## ASV5635             NA         NA         NA       NA    
## ASV5743             NA         NA         NA       NA    
## ASV6627             NA         NA         NA       NA    
## ASV6785             NA         NA         NA       NA    
## ASV7368             NA         NA         NA       NA    
## ASV9118             NA         NA         NA       NA    
## ASV9135             NA         NA         NA       NA    
## ASV9435             NA         NA         NA       NA    
## ASV9671             NA         NA         NA       NA    
## ASV0387             NA         NA         NA       NA    
## ASV0454             NA         NA         NA       NA    
## ASV0751             NA         NA         NA       NA    
## ASV1081             NA         NA         NA       NA    
## ASV1332             NA         NA         NA       NA    
## ASV2659             NA         NA         NA       NA    
## ASV2979             NA         NA         NA       NA    
## ASV4184             NA         NA         NA       NA    
## ASV6198             NA         NA         NA       NA    
## ASV7454             NA         NA         NA       NA    
## ASV8198             NA         NA         NA       NA    
## ASV0855             NA         NA         NA       NA    
## ASV10092            NA         NA         NA       NA    
## ASV1532             NA         NA         NA       NA    
## ASV2553             NA         NA         NA       NA    
## ASV2741             NA         NA         NA       NA    
## ASV4095             NA         NA         NA       NA    
## ASV5295             NA         NA         NA       NA    
## ASV5787             NA         NA         NA       NA    
## ASV9455             NA         NA         NA       NA    
## ASV10879            NA         NA         NA       NA    
## ASV3997             NA         NA         NA       NA    
## ASV6760             NA         NA         NA       NA    
## ASV6990             NA         NA         NA       NA    
## ASV9560             NA         NA         NA       NA    
## ASV0220             NA         NA         NA       NA    
## ASV2518             NA         NA         NA       NA    
## ASV3615             NA         NA         NA       NA    
## ASV0075             NA         NA         NA       NA    
## ASV8070             NA         NA         NA       NA    
## ASV1658             NA         NA         NA       NA    
## ASV0773             NA         NA         NA       NA    
## ASV0799             NA         NA         NA       NA    
## ASV1839             NA         NA         NA       NA    
## ASV0265             NA         NA         NA       NA    
## ASV3741             NA         NA         NA       NA    
## ASV0847             NA         NA         NA       NA    
## ASV1026             NA         NA         NA       NA    
## ASV1222             NA         NA         NA       NA    
## ASV0729             NA         NA         NA       NA    
## ASV0143             NA         NA         NA       NA    
## ASV1328             NA         NA         NA       NA    
## ASV9078             NA         NA         NA       NA    
## ASV0027             NA         NA         NA       NA    
## ASV0546             NA         NA         NA       NA    
## ASV1136             NA         NA         NA       NA    
## ASV3081             NA         NA         NA       NA    
## ASV0531             NA         NA         NA       NA    
## ASV2525             NA         NA         NA       NA    
## ASV1083             NA         NA         NA       NA    
## ASV0424             NA         NA         NA       NA    
## ASV0644             NA         NA         NA       NA    
## ASV6007             NA         NA         NA       NA    
## ASV0564             NA         NA         NA       NA    
## ASV1938             NA         NA         NA       NA    
## ASV6516             NA         NA         NA       NA    
## ASV0503             NA         NA         NA       NA    
## ASV6913             NA         NA         NA       NA    
## ASV0164             NA         NA         NA       NA    
## ASV1576             NA         NA         NA       NA    
## ASV1725             NA         NA         NA       NA    
## ASV4501             NA         NA         NA       NA    
## ASV10678            NA         NA         NA       NA    
## ASV0944             NA         NA         NA       NA    
## ASV2292             NA         NA         NA       NA    
## ASV1090             NA         NA         NA       NA    
## ASV9117             NA         NA         NA       NA    
## ASV0285             NA         NA         NA       NA    
## ASV0463             NA         NA         NA       NA    
## ASV3199             NA         NA         NA       NA    
## ASV0150             NA         NA         NA       NA    
## ASV6583             NA         NA         NA       NA    
## ASV0392             NA         NA         NA       NA    
## ASV14007            NA         NA         NA       NA    
## ASV0177             NA         NA         NA       NA    
## ASV6448             NA         NA         NA       NA    
## ASV5399             NA         NA         NA       NA    
## ASV0277             NA         NA         NA       NA    
## ASV2599             NA         NA         NA       NA    
## ASV13465            NA         NA         NA       NA    
## ASV2412             NA         NA         NA       NA    
## ASV0423             NA         NA         NA       NA    
## ASV5187             NA         NA         NA       NA    
## ASV0701             NA         NA         NA       NA    
## ASV4248             NA         NA         NA       NA    
## ASV0519     -3.661e+37  1.749e+21 -2.093e+16   <2e-16 ***
## ASV0764             NA         NA         NA       NA    
## ASV5385             NA         NA         NA       NA    
## ASV3021             NA         NA         NA       NA    
## ASV4119             NA         NA         NA       NA    
## ASV2534             NA         NA         NA       NA    
## ASV1061             NA         NA         NA       NA    
## ASV0670             NA         NA         NA       NA    
## ASV1384             NA         NA         NA       NA    
## ASV1981             NA         NA         NA       NA    
## ASV9632             NA         NA         NA       NA    
## ASV4564             NA         NA         NA       NA    
## ASV5289             NA         NA         NA       NA    
## ASV0516             NA         NA         NA       NA    
## ASV1463             NA         NA         NA       NA    
## ASV0969             NA         NA         NA       NA    
## ASV1113             NA         NA         NA       NA    
## ASV1234             NA         NA         NA       NA    
## ASV3814             NA         NA         NA       NA    
## ASV1000             NA         NA         NA       NA    
## ASV0079             NA         NA         NA       NA    
## ASV0145             NA         NA         NA       NA    
## ASV0457             NA         NA         NA       NA    
## ASV1485             NA         NA         NA       NA    
## ASV0535             NA         NA         NA       NA    
## ASV0259             NA         NA         NA       NA    
## ASV0570             NA         NA         NA       NA    
## ASV0906             NA         NA         NA       NA    
## ASV1748             NA         NA         NA       NA    
## ASV5520             NA         NA         NA       NA    
## ASV2288             NA         NA         NA       NA    
## ASV1887             NA         NA         NA       NA    
## ASV0374             NA         NA         NA       NA    
## ASV0823             NA         NA         NA       NA    
## ASV0717             NA         NA         NA       NA    
## ASV0431             NA         NA         NA       NA    
## ASV1030             NA         NA         NA       NA    
## ASV1082             NA         NA         NA       NA    
## ASV2684             NA         NA         NA       NA    
## ASV0051             NA         NA         NA       NA    
## ASV0513             NA         NA         NA       NA    
## ASV0581             NA         NA         NA       NA    
## ASV7282             NA         NA         NA       NA    
## ASV3009     -2.263e+36  2.047e+20 -1.106e+16   <2e-16 ***
## ASV2106             NA         NA         NA       NA    
## ASV1012             NA         NA         NA       NA    
## ASV0921             NA         NA         NA       NA    
## ASV0010             NA         NA         NA       NA    
## ASV1178             NA         NA         NA       NA    
## ASV2848             NA         NA         NA       NA    
## ASV0586             NA         NA         NA       NA    
## ASV4225             NA         NA         NA       NA    
## ASV2156             NA         NA         NA       NA    
## ASV9778             NA         NA         NA       NA    
## ASV0493             NA         NA         NA       NA    
## ASV3770             NA         NA         NA       NA    
## ASV0470             NA         NA         NA       NA    
## ASV0262             NA         NA         NA       NA    
## ASV0998             NA         NA         NA       NA    
## ASV7708             NA         NA         NA       NA    
## ASV0453             NA         NA         NA       NA    
## ASV0044             NA         NA         NA       NA    
## ASV5490             NA         NA         NA       NA    
## ASV2638             NA         NA         NA       NA    
## ASV0829             NA         NA         NA       NA    
## ASV0601             NA         NA         NA       NA    
## ASV0234             NA         NA         NA       NA    
## ASV0133             NA         NA         NA       NA    
## ASV0323             NA         NA         NA       NA    
## ASV0854             NA         NA         NA       NA    
## ASV0110             NA         NA         NA       NA    
## ASV0816             NA         NA         NA       NA    
## ASV1031             NA         NA         NA       NA    
## ASV0144             NA         NA         NA       NA    
## ASV0020             NA         NA         NA       NA    
## ASV0962             NA         NA         NA       NA    
## ASV0794             NA         NA         NA       NA    
## ASV7117             NA         NA         NA       NA    
## ASV1008             NA         NA         NA       NA    
## ASV0096             NA         NA         NA       NA    
## ASV0128             NA         NA         NA       NA    
## ASV5232             NA         NA         NA       NA    
## ASV0031             NA         NA         NA       NA    
## ASV1744             NA         NA         NA       NA    
## ASV0289             NA         NA         NA       NA    
## ASV7413             NA         NA         NA       NA    
## ASV0822             NA         NA         NA       NA    
## ASV8111             NA         NA         NA       NA    
## ASV0687             NA         NA         NA       NA    
## ASV0112             NA         NA         NA       NA    
## ASV0987             NA         NA         NA       NA    
## ASV5332             NA         NA         NA       NA    
## ASV1129             NA         NA         NA       NA    
## ASV1274             NA         NA         NA       NA    
## ASV0119             NA         NA         NA       NA    
## ASV0890             NA         NA         NA       NA    
## ASV0848             NA         NA         NA       NA    
## ASV5944             NA         NA         NA       NA    
## ASV19741            NA         NA         NA       NA    
## ASV0504             NA         NA         NA       NA    
## ASV2146             NA         NA         NA       NA    
## ASV0089             NA         NA         NA       NA    
## ASV2301             NA         NA         NA       NA    
## ASV2982             NA         NA         NA       NA    
## ASV0891             NA         NA         NA       NA    
## ASV0093             NA         NA         NA       NA    
## ASV0042             NA         NA         NA       NA    
## ASV0980             NA         NA         NA       NA    
## ASV0069             NA         NA         NA       NA    
## ASV1364             NA         NA         NA       NA    
## ASV0524             NA         NA         NA       NA    
## ASV0435             NA         NA         NA       NA    
## ASV0517             NA         NA         NA       NA    
## ASV3167             NA         NA         NA       NA    
## ASV4280             NA         NA         NA       NA    
## ASV1158             NA         NA         NA       NA    
## ASV2214             NA         NA         NA       NA    
## ASV0544             NA         NA         NA       NA    
## ASV5326             NA         NA         NA       NA    
## ASV3765             NA         NA         NA       NA    
## ASV4646             NA         NA         NA       NA    
## ASV0090             NA         NA         NA       NA    
## ASV3680             NA         NA         NA       NA    
## ASV0111             NA         NA         NA       NA    
## ASV0768             NA         NA         NA       NA    
## ASV4862             NA         NA         NA       NA    
## ASV1742             NA         NA         NA       NA    
## ASV3701             NA         NA         NA       NA    
## ASV2386             NA         NA         NA       NA    
## ASV0375             NA         NA         NA       NA    
## ASV2796             NA         NA         NA       NA    
## ASV1369             NA         NA         NA       NA    
## ASV10272            NA         NA         NA       NA    
## ASV10354            NA         NA         NA       NA    
## ASV1067             NA         NA         NA       NA    
## ASV1900             NA         NA         NA       NA    
## ASV4079             NA         NA         NA       NA    
## ASV4149             NA         NA         NA       NA    
## ASV5140             NA         NA         NA       NA    
## ASV10782            NA         NA         NA       NA    
## ASV4273             NA         NA         NA       NA    
## ASV8121             NA         NA         NA       NA    
## ASV8438             NA         NA         NA       NA    
## ASV9390             NA         NA         NA       NA    
## ASV1340             NA         NA         NA       NA    
## ASV2650             NA         NA         NA       NA    
## ASV4674             NA         NA         NA       NA    
## ASV10492            NA         NA         NA       NA    
## ASV11430            NA         NA         NA       NA    
## ASV12135            NA         NA         NA       NA    
## ASV14970            NA         NA         NA       NA    
## ASV1954             NA         NA         NA       NA    
## ASV2613             NA         NA         NA       NA    
## ASV2757             NA         NA         NA       NA    
## ASV2909             NA         NA         NA       NA    
## ASV2954             NA         NA         NA       NA    
## ASV2969             NA         NA         NA       NA    
## ASV3410             NA         NA         NA       NA    
## ASV3575             NA         NA         NA       NA    
## ASV4275             NA         NA         NA       NA    
## ASV4652             NA         NA         NA       NA    
## ASV4761             NA         NA         NA       NA    
## ASV6003             NA         NA         NA       NA    
## ASV6110             NA         NA         NA       NA    
## ASV7427             NA         NA         NA       NA    
## ASV8092             NA         NA         NA       NA    
## ASV8169             NA         NA         NA       NA    
## ASV9693             NA         NA         NA       NA    
## ASV10913            NA         NA         NA       NA    
## ASV1979             NA         NA         NA       NA    
## ASV3772             NA         NA         NA       NA    
## ASV0113             NA         NA         NA       NA    
## ASV1800             NA         NA         NA       NA    
## ASV2335             NA         NA         NA       NA    
## ASV0692             NA         NA         NA       NA    
## ASV1120             NA         NA         NA       NA    
## ASV1434             NA         NA         NA       NA    
## ASV0076             NA         NA         NA       NA    
## ASV0361             NA         NA         NA       NA    
## ASV2231             NA         NA         NA       NA    
## ASV2018             NA         NA         NA       NA    
## ASV1529             NA         NA         NA       NA    
## ASV0841             NA         NA         NA       NA    
## ASV2556             NA         NA         NA       NA    
## ASV2777             NA         NA         NA       NA    
## ASV0355             NA         NA         NA       NA    
## ASV5169             NA         NA         NA       NA    
## ASV3091             NA         NA         NA       NA    
## ASV2435             NA         NA         NA       NA    
## ASV6822             NA         NA         NA       NA    
## ASV12605            NA         NA         NA       NA    
## ASV0286             NA         NA         NA       NA    
## ASV0074             NA         NA         NA       NA    
## ASV2485             NA         NA         NA       NA    
## ASV1233             NA         NA         NA       NA    
## ASV0356             NA         NA         NA       NA    
## ASV2918             NA         NA         NA       NA    
## ASV1427             NA         NA         NA       NA    
## ASV1409             NA         NA         NA       NA    
## ASV0770             NA         NA         NA       NA    
## ASV1403             NA         NA         NA       NA    
## ASV0314             NA         NA         NA       NA    
## ASV0187             NA         NA         NA       NA    
## ASV0313             NA         NA         NA       NA    
## ASV1087             NA         NA         NA       NA    
## ASV1970             NA         NA         NA       NA    
## ASV0754             NA         NA         NA       NA    
## ASV3775             NA         NA         NA       NA    
## ASV0132             NA         NA         NA       NA    
## ASV2329             NA         NA         NA       NA    
## ASV0561             NA         NA         NA       NA    
## ASV0130             NA         NA         NA       NA    
## ASV0226             NA         NA         NA       NA    
## ASV12648            NA         NA         NA       NA    
## ASV0204             NA         NA         NA       NA    
## ASV0767             NA         NA         NA       NA    
## ASV0335             NA         NA         NA       NA    
## ASV5901             NA         NA         NA       NA    
## ASV0596             NA         NA         NA       NA    
## ASV9271             NA         NA         NA       NA    
## ASV0904             NA         NA         NA       NA    
## ASV15270            NA         NA         NA       NA    
## ASV0990             NA         NA         NA       NA    
## ASV0155             NA         NA         NA       NA    
## ASV0086             NA         NA         NA       NA    
## ASV2581             NA         NA         NA       NA    
## ASV1579             NA         NA         NA       NA    
## ASV7730             NA         NA         NA       NA    
## ASV0897             NA         NA         NA       NA    
## ASV1975             NA         NA         NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:  385.39  on 277  degrees of freedom
## Residual deviance: 9443.44  on  42  degrees of freedom
## AIC: 9915.4
## 
## Number of Fisher Scoring iterations: 5
pchisq(logreg_1000$null.deviance, logreg_1000$df.null, lower.tail = FALSE)
## [1] 1.735332e-05
  • The above statistical test indicates that there is evidence for the alternative hypothesis that the model with predictors is much better than the null model with the intercept.
# Bad fit in notes example had a p-value of 0.9995629 from Ressler
# good fit would be the opposite
pchisq(logreg_1000$deviance, logreg_1000$df.residual, lower.tail = FALSE)
## [1] 0

Using top 500 ASVs to see if the model improves

# lr_clr_df %>% 
#   select(1:502) -> lr_clr_df_500 # because of id column and response column


lr_data[,1:502] -> lr_data_500
 
  
bind_cols(lr_data_500[,1:2], 
          lr_data_500[,-c(1,2)] %>% clr()
            ) -> lr_clr_df_500

dim(lr_clr_df_500)
## [1] 278 502
head(lr_clr_df_500)
## # A tibble: 6 × 502
##   sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##   <chr>      <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
## 1 SKAU-R2-23     1    0      0       0       0      0        0       0    
## 2 SWAJ-R4-3      0    0      0       0       0      0        0       0    
## 3 SYAN-R3-19     1    0      0       0       0      0        0       0    
## 4 PMAQ-R2-19     0    0      0       0       0      0        0       0    
## 5 SDOG-R3-6      0    0      0       0       0      0        0       0    
## 6 PDOG-R2-22     0    1.38   0.912   0.421   0.556  0.0158  -0.341  -0.187
## # ℹ 493 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …

Logistic with Reduced 500 ASVs

glmnet::glmnet

re-do with model.matrix

y = as.factor(lr_clr_df_500$Clade)
x = as.matrix(lr_clr_df_500[,-c(1,2)])

glimpse(y)
##  Factor w/ 2 levels "0","1": 2 1 2 1 1 1 1 1 2 1 ...
dim(x)
## [1] 278 500
library(glmnet)
lr_model_500 <- glmnet(x, y, 
                        family = "binomial", 
                        #alpha = 1 ,# lasso L1 norm
                        alpha = 0 # ridge L2 norm
                )
lr_model_500
## 
## Call:  glmnet(x = x, y = y, family = "binomial", alpha = 0) 
## 
##      Df  %Dev  Lambda
## 1   500  0.00 171.800
## 2   500  0.65 164.000
## 3   500  0.68 156.500
## 4   500  0.72 149.400
## 5   500  0.75 142.600
## 6   500  0.78 136.200
## 7   500  0.82 130.000
## 8   500  0.86 124.100
## 9   500  0.90 118.400
## 10  500  0.94 113.000
## 11  500  0.98 107.900
## 12  500  1.03 103.000
## 13  500  1.07  98.320
## 14  500  1.12  93.850
## 15  500  1.17  89.580
## 16  500  1.23  85.510
## 17  500  1.28  81.620
## 18  500  1.34  77.910
## 19  500  1.40  74.370
## 20  500  1.46  70.990
## 21  500  1.53  67.770
## 22  500  1.60  64.690
## 23  500  1.67  61.750
## 24  500  1.74  58.940
## 25  500  1.82  56.260
## 26  500  1.90  53.700
## 27  500  1.98  51.260
## 28  500  2.07  48.930
## 29  500  2.16  46.710
## 30  500  2.26  44.580
## 31  500  2.35  42.560
## 32  500  2.46  40.620
## 33  500  2.56  38.780
## 34  500  2.67  37.020
## 35  500  2.79  35.330
## 36  500  2.91  33.730
## 37  500  3.03  32.190
## 38  500  3.16  30.730
## 39  500  3.29  29.330
## 40  500  3.43  28.000
## 41  500  3.57  26.730
## 42  500  3.71  25.510
## 43  500  3.87  24.350
## 44  500  4.03  23.250
## 45  500  4.19  22.190
## 46  500  4.36  21.180
## 47  500  4.53  20.220
## 48  500  4.71  19.300
## 49  500  4.90  18.420
## 50  500  5.09  17.590
## 51  500  5.29  16.790
## 52  500  5.49  16.020
## 53  500  5.70  15.290
## 54  500  5.92  14.600
## 55  500  6.15  13.940
## 56  500  6.38  13.300
## 57  500  6.61  12.700
## 58  500  6.86  12.120
## 59  500  7.11  11.570
## 60  500  7.36  11.040
## 61  500  7.63  10.540
## 62  500  7.90  10.060
## 63  500  8.16   9.606
## 64  500  8.44   9.169
## 65  500  8.74   8.752
## 66  500  9.03   8.354
## 67  500  9.34   7.975
## 68  500  9.65   7.612
## 69  500  9.97   7.266
## 70  500 10.30   6.936
## 71  500 10.64   6.621
## 72  500 10.98   6.320
## 73  500 11.33   6.033
## 74  500 11.68   5.758
## 75  500 12.05   5.497
## 76  500 12.42   5.247
## 77  500 12.80   5.008
## 78  500 13.18   4.781
## 79  500 13.57   4.563
## 80  500 13.97   4.356
## 81  500 14.38   4.158
## 82  500 14.79   3.969
## 83  500 15.21   3.789
## 84  500 15.64   3.616
## 85  500 16.07   3.452
## 86  500 16.51   3.295
## 87  500 16.96   3.145
## 88  500 17.41   3.002
## 89  500 17.87   2.866
## 90  500 18.34   2.736
## 91  500 18.81   2.611
## 92  500 19.29   2.493
## 93  500 19.77   2.379
## 94  500 20.26   2.271
## 95  500 20.75   2.168
## 96  500 21.25   2.069
## 97  500 21.76   1.975
## 98  500 22.27   1.886
## 99  500 22.79   1.800
## 100 500 23.31   1.718
summary(lr_model_500)
##            Length Class     Mode     
## a0           100  -none-    numeric  
## beta       50000  dgCMatrix S4       
## df           100  -none-    numeric  
## dim            2  -none-    numeric  
## lambda       100  -none-    numeric  
## dev.ratio    100  -none-    numeric  
## nulldev        1  -none-    numeric  
## npasses        1  -none-    numeric  
## jerr           1  -none-    numeric  
## offset         1  -none-    logical  
## classnames     2  -none-    character
## call           5  -none-    call     
## nobs           1  -none-    numeric
plot(lr_model_500)

#plot(lr_model_500, xlim = c(0, 50), ylim = c(-0.02, 0.02))

Cross-Validation

cv_results_500 <- cv.glmnet(x, y,
                        family = "binomial",
                        nfolds = 10)
plot(cv_results_500)

best_lambda_500 <- lr_model_500$lambda.min

# Refit the model with the selected lambda
best_model_500 <- glmnet(x, y, family = "binomial", alpha = 0, lambda = best_lambda_500)

coef(best_model_500)
## 501 x 100 sparse Matrix of class "dgCMatrix"
##   [[ suppressing 100 column names 's0', 's1', 's2' ... ]]
##                                                                    
## (Intercept) -1.249001e-16  7.230358e-03  7.573680e-03  7.929354e-03
## ASV1236      2.487736e-37  1.463110e-03  1.532663e-03  1.603685e-03
## ASV0421      2.256405e-38  1.443794e-04  1.512077e-04  1.588388e-04
## ASV0691     -2.053902e-37 -1.184307e-03 -1.240601e-03 -1.296807e-03
## ASV0899      2.141697e-37  1.262958e-03  1.323022e-03  1.384483e-03
## ASV1004      4.960527e-37  2.922185e-03  3.061099e-03  3.203124e-03
## ASV1041     -2.046369e-37 -1.204711e-03 -1.261847e-03 -1.320366e-03
## ASV1058      3.102249e-37  1.826193e-03  1.912922e-03  2.001604e-03
## ASV12542     1.226446e-37  7.171132e-04  7.512680e-04  7.858314e-04
## ASV1294      2.883128e-37  1.698038e-03  1.778655e-03  1.861164e-03
## ASV13113     8.911866e-38  5.392071e-04  5.648677e-04  5.918199e-04
## ASV1318      2.876637e-37  1.693994e-03  1.774347e-03  1.856655e-03
## ASV2269     -4.993241e-37 -2.938835e-03 -3.077379e-03 -3.220177e-03
## ASV2542      2.317035e-37  1.386484e-03  1.452256e-03  1.520778e-03
## ASV2660     -1.997156e-37 -1.173354e-03 -1.228690e-03 -1.285566e-03
## ASV2737      7.166447e-38  4.155459e-04  4.355030e-04  4.553414e-04
## ASV2840      2.714301e-37  1.584306e-03  1.659334e-03  1.735538e-03
## ASV3053      1.377147e-36  8.061227e-03  8.442035e-03  8.830942e-03
## ASV3077      8.757045e-38  5.130382e-04  5.373373e-04  5.621007e-04
## ASV3134      1.443337e-37  8.688657e-04  9.101903e-04  9.533946e-04
## ASV3140      2.022261e-37  1.203838e-03  1.260835e-03  1.320019e-03
## ASV3579      6.644802e-38  4.061470e-04  4.255919e-04  4.460977e-04
## ASV6119     -1.366643e-37 -8.043544e-04 -8.422099e-04 -8.812870e-04
## ASV7557     -2.777344e-37 -1.634640e-03 -1.711449e-03 -1.790852e-03
## ASV8422      7.020134e-38  4.107460e-04  4.304933e-04  4.503067e-04
## ASV1086     -1.179996e-38 -6.733132e-05 -7.055854e-05 -7.369918e-05
## ASV1310      1.328433e-37  7.820533e-04  8.191971e-04  8.571729e-04
## ASV15750    -1.897072e-38 -1.100230e-04 -1.150947e-04 -1.203567e-04
## ASV16905    -5.711172e-38 -3.361378e-04 -3.519328e-04 -3.682600e-04
## ASV2033      2.302796e-37  1.382955e-03  1.448850e-03  1.517448e-03
## ASV2089      1.203196e-37  7.083884e-04  7.416680e-04  7.760912e-04
## ASV2127      3.905460e-37  2.298912e-03  2.407907e-03  2.519534e-03
## ASV2725      3.164200e-37  1.854292e-03  1.942307e-03  2.031907e-03
## ASV2804     -1.182307e-37 -6.958605e-04 -7.285275e-04 -7.623248e-04
## ASV3075      2.531982e-37  1.501481e-03  1.572816e-03  1.646310e-03
## ASV3327      3.424690e-37  2.047582e-03  2.145166e-03  2.246269e-03
## ASV3342      2.961100e-37  1.766850e-03  1.850597e-03  1.937666e-03
## ASV3532     -3.300146e-37 -1.962344e-03 -2.054883e-03 -2.151232e-03
## ASV3600      1.527807e-37  9.094804e-04  9.527511e-04  9.974474e-04
## ASV4013      2.900367e-37  1.716052e-03  1.797531e-03  1.881309e-03
## ASV4136      3.172587e-37  1.860046e-03  1.947995e-03  2.037938e-03
## ASV4195      1.206964e-36  7.103729e-03  7.436558e-03  7.781518e-03
## ASV4407     -4.663522e-37 -2.744770e-03 -2.873165e-03 -3.006434e-03
## ASV4717      8.506359e-38  4.915469e-04  5.154315e-04  5.388225e-04
## ASV6794      1.975909e-37  1.152569e-03  1.207509e-03  1.262924e-03
## ASV8324     -2.392925e-37 -1.408383e-03 -1.474284e-03 -1.542664e-03
## ASV8981     -8.352057e-39 -4.426868e-05 -4.614359e-05 -4.803271e-05
## ASV9859      7.364704e-38  4.523909e-04  4.741369e-04  4.971056e-04
## ASV0936      2.228490e-37  1.330932e-03  1.393841e-03  1.459488e-03
## ASV12683     6.041569e-40  1.425662e-06  1.778646e-06  1.737172e-06
## ASV1293      1.555205e-37  9.143034e-04  9.575095e-04  1.001843e-03
## ASV13055    -5.436579e-39 -2.863881e-05 -2.958808e-05 -3.079128e-05
## ASV17063    -1.241828e-37 -7.308914e-04 -7.648828e-04 -8.003506e-04
## ASV2228      1.012776e-37  5.960806e-04  6.237582e-04  6.526799e-04
## ASV2769      1.316397e-38  8.300106e-05  8.731841e-05  9.164733e-05
## ASV2803      1.125761e-37  6.553723e-04  6.867086e-04  7.181488e-04
## ASV2896      8.363712e-38  5.000113e-04  5.238930e-04  5.485832e-04
## ASV3062      9.679797e-38  5.878085e-04  6.162170e-04  6.457210e-04
## ASV3107      1.568591e-37  9.359311e-04  9.804783e-04  1.026589e-03
## ASV3265      2.228976e-37  1.309662e-03  1.371569e-03  1.435018e-03
## ASV3666      2.400919e-39  1.334049e-05  1.432574e-05  1.493994e-05
## ASV4497      7.580134e-38  4.467574e-04  4.681643e-04  4.898883e-04
## ASV6914     -9.734870e-39 -6.102543e-05 -6.366593e-05 -6.682414e-05
## ASV0576     -2.743255e-37 -1.593636e-03 -1.669158e-03 -1.745420e-03
## ASV0673      2.900369e-37  1.714445e-03  1.795632e-03  1.879238e-03
## ASV0772      1.338351e-37  7.925904e-04  8.302808e-04  8.690117e-04
## ASV0862      6.088647e-39  5.090383e-05  5.333672e-05  5.662393e-05
## ASV0898      9.946095e-38  5.989665e-04  6.274025e-04  6.572056e-04
## ASV0910      1.169851e-37  6.994155e-04  7.326333e-04  7.671623e-04
## ASV0964     -1.025694e-37 -5.982967e-04 -6.267623e-04 -6.555049e-04
## ASV10059     8.090263e-38  4.887691e-04  5.121472e-04  5.365449e-04
## ASV10263    -1.890019e-37 -1.112391e-03 -1.164591e-03 -1.218597e-03
## ASV1088      2.104846e-37  1.253932e-03  1.313475e-03  1.375157e-03
## ASV1101      2.708230e-37  1.592160e-03  1.667505e-03  1.744687e-03
## ASV1183      6.943282e-38  4.128824e-04  4.323342e-04  4.526033e-04
## ASV11956     7.183437e-38  4.166133e-04  4.365471e-04  4.564495e-04
## ASV12774     6.039882e-39  3.109980e-05  3.268507e-05  3.395460e-05
## ASV1321      2.999660e-37  1.797893e-03  1.883460e-03  1.972451e-03
## ASV13793    -1.303199e-37 -7.670116e-04 -8.029863e-04 -8.402204e-04
## ASV14482     9.146381e-39  5.177452e-05  5.435880e-05  5.676294e-05
## ASV15483     5.138747e-38  3.069552e-04  3.216649e-04  3.368064e-04
## ASV2062      2.465653e-37  1.457710e-03  1.526585e-03  1.597681e-03
## ASV2132      1.960660e-37  1.170330e-03  1.226003e-03  1.283687e-03
## ASV2413      1.928046e-37  1.135153e-03  1.188761e-03  1.243870e-03
## ASV2490      6.044612e-37  3.535343e-03  3.702192e-03  3.872612e-03
## ASV2594      7.224511e-38  4.293504e-04  4.497035e-04  4.707606e-04
## ASV2822     -3.438221e-37 -2.023601e-03 -2.118813e-03 -2.217071e-03
## ASV2863      3.691454e-37  2.165241e-03  2.266918e-03  2.371611e-03
## ASV2910      1.341449e-37  7.886411e-04  8.260423e-04  8.642782e-04
## ASV2980      1.470464e-37  8.703498e-04  9.113833e-04  9.538976e-04
## ASV3307      2.736224e-37  1.610433e-03  1.685972e-03  1.764146e-03
## ASV3474      1.702363e-37  1.023809e-03  1.072548e-03  1.123404e-03
## ASV3502      1.850029e-37  1.098767e-03  1.150861e-03  1.204721e-03
## ASV4236      2.853685e-37  1.667402e-03  1.745495e-03  1.825714e-03
## ASV4842     -2.808639e-38 -1.696588e-04 -1.777450e-04 -1.862407e-04
## ASV4894     -1.303199e-37 -7.670113e-04 -8.030663e-04 -8.403055e-04
## ASV5290      9.977313e-38  5.949107e-04  6.232675e-04  6.525590e-04
## ASV5501      6.181106e-38  3.667380e-04  3.840667e-04  4.020066e-04
## ASV5795      6.687574e-38  3.991943e-04  4.181489e-04  4.378147e-04
## ASV5987     -3.639689e-37 -2.142177e-03 -2.242998e-03 -2.347014e-03
## ASV6267     -4.101457e-37 -2.413954e-03 -2.527386e-03 -2.644584e-03
## ASV6862      1.673295e-37  9.787335e-04  1.024940e-03  1.072122e-03
## ASV7145      7.508590e-38  4.365964e-04  4.570309e-04  4.779158e-04
## ASV7673     -1.303199e-37 -7.670111e-04 -8.030433e-04 -8.402803e-04
## ASV7789      5.783507e-38  3.543060e-04  3.713142e-04  3.892490e-04
## ASV7809      1.757340e-39  1.580454e-05  1.673353e-05  1.778828e-05
## ASV8002     -1.645936e-37 -9.687325e-04 -1.014213e-03 -1.061242e-03
## ASV8205      6.668736e-38  3.969001e-04  4.158856e-04  4.353895e-04
## ASV9155     -4.257445e-38 -2.491214e-04 -2.607313e-04 -2.727482e-04
## ASV9221      1.231155e-38  8.180940e-05  8.599872e-05  9.047087e-05
## ASV9311     -2.640533e-37 -1.554112e-03 -1.626993e-03 -1.702434e-03
## ASV9557     -1.804719e-37 -1.062186e-03 -1.111918e-03 -1.163472e-03
## ASV9936     -3.639689e-37 -2.142176e-03 -2.242314e-03 -2.346273e-03
## ASV1445      2.135517e-37  1.272034e-03  1.332463e-03  1.395013e-03
## ASV4232      7.778344e-38  4.695706e-04  4.919761e-04  5.153997e-04
## ASV6479      2.320402e-38  1.500966e-04  1.575118e-04  1.655191e-04
## ASV0142     -1.578646e-37 -9.267364e-04 -9.704482e-04 -1.015296e-03
## ASV0378      6.612904e-38  3.996131e-04  4.186946e-04  4.386577e-04
## ASV1122      2.054769e-37  1.226596e-03  1.284824e-03  1.345276e-03
## ASV0123     -1.396268e-37 -8.192738e-04 -8.578535e-04 -8.974746e-04
## ASV2064      7.388904e-38  4.285596e-04  4.487405e-04  4.691962e-04
## ASV4459     -1.114934e-38 -6.308509e-05 -6.590210e-05 -6.883594e-05
## ASV0448      5.279280e-38  3.192338e-04  3.344890e-04  3.504475e-04
## ASV0397      1.231244e-37  7.299771e-04  7.645961e-04  8.003188e-04
## ASV0485      1.447589e-37  8.547848e-04  8.951634e-04  9.368023e-04
## ASV1566      2.112454e-37  1.251630e-03  1.310918e-03  1.372107e-03
## ASV1365      1.784911e-37  1.061585e-03  1.111986e-03  1.164099e-03
## ASV1065      2.543300e-37  1.511342e-03  1.582767e-03  1.656884e-03
## ASV0722     -1.286640e-38 -7.719078e-05 -8.094111e-05 -8.476776e-05
## ASV12660    -1.520279e-37 -8.903256e-04 -9.322547e-04 -9.752425e-04
## ASV0223      3.987436e-38  2.356668e-04  2.467827e-04  2.582761e-04
## ASV0229      5.909607e-38  3.529198e-04  3.696309e-04  3.870359e-04
## ASV0877      2.709244e-38  1.568353e-04  1.645104e-04  1.719975e-04
## ASV0983      1.443019e-37  8.509497e-04  8.910979e-04  9.324839e-04
## ASV0626      1.069392e-38  7.289410e-05  7.678054e-05  8.086968e-05
## ASV4146      7.018615e-39  4.151662e-05  4.374779e-05  4.578268e-05
## ASV4175     -1.721376e-37 -1.027050e-03 -1.075432e-03 -1.126010e-03
## ASV2082     -6.886168e-38 -4.283149e-04 -4.492945e-04 -4.713425e-04
## ASV2272      8.243704e-38  4.905654e-04  5.138670e-04  5.379655e-04
## ASV2245     -1.222952e-37 -7.311238e-04 -7.655222e-04 -8.015989e-04
## ASV0590     -6.226416e-38 -3.938630e-04 -4.131619e-04 -4.337626e-04
## ASV0217     -2.467240e-41  1.339699e-05  1.435210e-05  1.573859e-05
## ASV0416      1.022443e-37  5.911662e-04  6.187600e-04  6.468749e-04
## ASV1056      1.166672e-37  7.004618e-04  7.339129e-04  7.686572e-04
## ASV7777     -1.685134e-37 -1.003358e-03 -1.050450e-03 -1.099744e-03
## ASV0455      3.043615e-38  1.808809e-04  1.893311e-04  1.981965e-04
## ASV0604      7.589291e-38  4.575182e-04  4.795244e-04  5.023255e-04
## ASV6100     -1.147947e-37 -6.861864e-04 -7.185141e-04 -7.523714e-04
## ASV11359    -2.493585e-37 -1.485498e-03 -1.555238e-03 -1.628250e-03
## ASV6604      3.353780e-38  2.018193e-04  2.115230e-04  2.215616e-04
## ASV5004     -8.938067e-38 -5.310547e-04 -5.558352e-04 -5.818549e-04
## ASV1483     -3.871356e-38 -2.297429e-04 -2.403053e-04 -2.515376e-04
## ASV9773     -1.118380e-37 -6.671445e-04 -6.985275e-04 -7.313681e-04
## ASV4059     -4.627373e-39 -1.756683e-05 -1.792067e-05 -1.823591e-05
## ASV1193      1.371693e-37  8.136857e-04  8.522776e-04  8.921136e-04
## ASV4610     -2.860207e-38 -1.548438e-04 -1.616953e-04 -1.684791e-04
## ASV0742     -1.865581e-38 -9.910372e-05 -1.032411e-04 -1.074527e-04
## ASV1502     -2.642974e-39 -2.329354e-05 -2.429901e-05 -2.583092e-05
## ASV0195      5.522991e-39  2.812831e-05  2.929936e-05  3.042629e-05
## ASV1213      1.021583e-37  5.948943e-04  6.223120e-04  6.508035e-04
## ASV1648     -1.033114e-37 -6.171668e-04 -6.461190e-04 -6.765420e-04
## ASV6984     -9.658686e-38 -5.771515e-04 -6.041988e-04 -6.326545e-04
## ASV0396     -8.034235e-39 -4.236190e-05 -4.432414e-05 -4.612056e-05
## ASV4297      1.458189e-37  8.530452e-04  8.934451e-04  9.345828e-04
## ASV2622      2.222363e-37  1.308347e-03  1.370090e-03  1.433605e-03
## ASV3512      7.742848e-38  4.741364e-04  4.970795e-04  5.211016e-04
## ASV2411      1.429132e-37  8.590270e-04  8.996739e-04  9.423115e-04
## ASV2291     -5.259632e-38 -3.353697e-04 -3.523668e-04 -3.700822e-04
## ASV0807      2.019113e-37  1.197978e-03  1.254793e-03  1.313458e-03
## ASV1292      5.260610e-38  3.041582e-04  3.181740e-04  3.326248e-04
## ASV1035      1.910905e-37  1.121293e-03  1.173809e-03  1.228025e-03
## ASV0070     -6.717654e-40  7.815653e-07  8.764265e-07  1.168480e-06
## ASV0255      1.878239e-38  1.089702e-04  1.139941e-04  1.191901e-04
## ASV0057     -5.375019e-38 -3.130531e-04 -3.277379e-04 -3.427506e-04
## ASV0077     -1.226748e-38 -6.969763e-05 -7.296237e-05 -7.621129e-05
## ASV0625      1.106794e-37  6.482927e-04  6.786492e-04  7.099303e-04
## ASV2464      7.574062e-37  4.425745e-03  4.632815e-03  4.845823e-03
## ASV1315      1.852940e-37  1.115459e-03  1.168617e-03  1.224096e-03
## ASV2673      1.587187e-37  9.559326e-04  1.001518e-03  1.049089e-03
## ASV2161      6.737911e-38  4.051060e-04  4.245017e-04  4.446316e-04
## ASV0337     -3.937361e-38 -2.350015e-04 -2.462519e-04 -2.578392e-04
## ASV7680     -2.563213e-37 -1.532316e-03 -1.604390e-03 -1.679983e-03
## ASV0611      1.429891e-37  8.547201e-04  8.953520e-04  9.375461e-04
## ASV3118     -1.447142e-37 -8.737759e-04 -9.149547e-04 -9.585148e-04
## ASV1284      6.892387e-38  3.779544e-04  3.946359e-04  4.114370e-04
## ASV0889      1.122835e-37  6.619902e-04  6.933899e-04  7.255900e-04
## ASV4649     -5.498583e-38 -3.271355e-04 -3.424530e-04 -3.585053e-04
## ASV1108     -1.069249e-37 -6.484139e-04 -6.791240e-04 -7.116065e-04
## ASV0738      5.575283e-38  3.456115e-04  3.621400e-04  3.798475e-04
## ASV0473     -9.838163e-39 -6.455051e-05 -6.791654e-05 -7.141922e-05
## ASV0598     -2.732378e-38 -1.719092e-04 -1.803882e-04 -1.893474e-04
## ASV0429      8.435277e-38  4.954548e-04  5.187945e-04  5.427815e-04
## ASV1549      1.462435e-37  8.813309e-04  9.232720e-04  9.671513e-04
## ASV1203      1.215512e-37  7.183730e-04  7.520381e-04  7.870386e-04
## ASV4532      6.312191e-39  3.479334e-05  3.647707e-05  3.804723e-05
## ASV0274      1.919434e-38  1.177399e-04  1.233509e-04  1.293179e-04
## ASV0163     -9.654467e-38 -5.646735e-04 -5.910525e-04 -6.182524e-04
## ASV1298      1.163196e-38  6.582687e-05  6.866742e-05  7.170660e-05
## ASV9424     -1.979031e-37 -1.184641e-03 -1.240492e-03 -1.299024e-03
## ASV0412      2.121998e-37  1.250738e-03  1.309651e-03  1.370441e-03
## ASV0284      4.776264e-38  2.743042e-04  2.869733e-04  2.999085e-04
## ASV0620     -3.805121e-38 -2.362331e-04 -2.474398e-04 -2.595529e-04
## ASV0153     -1.955205e-37 -1.178042e-03 -1.234464e-03 -1.293131e-03
## ASV0498      7.037437e-38  4.211623e-04  4.410366e-04  4.618384e-04
## ASV0097      3.845139e-38  2.316478e-04  2.426316e-04  2.541582e-04
## ASV0104     -2.841211e-37 -1.683265e-03 -1.763082e-03 -1.845380e-03
## ASV1282      1.007173e-37  5.906649e-04  6.186857e-04  6.472497e-04
## ASV3883     -7.187674e-38 -4.394211e-04 -4.602827e-04 -4.824736e-04
## ASV0801      3.760145e-38  2.250749e-04  2.354671e-04  2.465699e-04
## ASV1611     -1.758382e-37 -1.056140e-03 -1.106072e-03 -1.158448e-03
## ASV0227     -2.801017e-38 -1.767251e-04 -1.853696e-04 -1.945910e-04
## ASV0833      6.076003e-38  3.627451e-04  3.799307e-04  3.978087e-04
## ASV0718      2.732113e-37  1.627699e-03  1.704635e-03  1.784672e-03
## ASV1139      4.099438e-38  2.315783e-04  2.421104e-04  2.528084e-04
## ASV0766     -3.558707e-38 -2.180584e-04 -2.283344e-04 -2.393652e-04
## ASV2091      2.321535e-37  1.360213e-03  1.424209e-03  1.489886e-03
## ASV1238     -2.004915e-37 -1.200648e-03 -1.257052e-03 -1.316389e-03
## ASV9193     -1.465827e-38 -9.832895e-05 -1.028894e-04 -1.082876e-04
## ASV0290      3.259335e-38  1.858275e-04  1.945680e-04  2.032742e-04
## ASV0231      8.351338e-38  4.924152e-04  5.155187e-04  5.394514e-04
## ASV0185      4.297712e-38  2.658654e-04  2.786276e-04  2.922255e-04
## ASV2330      9.855876e-38  5.747612e-04  6.017663e-04  6.293737e-04
## ASV3119     -3.916122e-38 -2.416953e-04 -2.532771e-04 -2.656079e-04
## ASV2368     -1.010761e-37 -6.093636e-04 -6.381468e-04 -6.684842e-04
## ASV0122     -5.149139e-38 -3.043439e-04 -3.188158e-04 -3.336630e-04
## ASV1044      1.266487e-37  7.605964e-04  7.967528e-04  8.344835e-04
## ASV0160     -5.728985e-38 -3.343060e-04 -3.499582e-04 -3.660236e-04
## ASV0326      1.419877e-38  8.483459e-05  8.892509e-05  9.311489e-05
## ASV1388      2.661082e-37  1.575669e-03  1.650190e-03  1.727169e-03
## ASV0792      2.012867e-37  1.183614e-03  1.239071e-03  1.296425e-03
## ASV0036     -5.858506e-38 -3.531615e-04 -3.700859e-04 -3.876831e-04
## ASV2125      1.892306e-37  1.122677e-03  1.175791e-03  1.230754e-03
## ASV1075     -2.883794e-39 -1.703759e-05 -1.778007e-05 -1.860677e-05
## ASV0390      9.693699e-38  5.840434e-04  6.117017e-04  6.407636e-04
## ASV3790     -1.407895e-37 -8.411432e-04 -8.808344e-04 -9.223117e-04
## ASV1535     -3.762637e-38 -2.315193e-04 -2.425484e-04 -2.543186e-04
## ASV0263      1.743826e-37  1.037556e-03  1.086346e-03  1.137272e-03
## ASV0675      2.570800e-37  1.540279e-03  1.613279e-03  1.689482e-03
## ASV3348      1.987912e-38  1.211834e-04  1.270920e-04  1.332075e-04
## ASV0058     -7.891385e-38 -4.668307e-04 -4.888627e-04 -5.116433e-04
## ASV4142      1.126786e-37  6.625684e-04  6.935596e-04  7.256603e-04
## ASV0059     -6.393267e-38 -3.774386e-04 -3.952055e-04 -4.135802e-04
## ASV0013     -1.114941e-37 -6.628337e-04 -6.942073e-04 -7.267301e-04
## ASV0033     -5.109579e-38 -3.076555e-04 -3.223457e-04 -3.376527e-04
## ASV4354     -6.571066e-38 -3.904904e-04 -4.088786e-04 -4.280248e-04
## ASV0022     -4.319647e-38 -2.600019e-04 -2.723832e-04 -2.853120e-04
## ASV0134     -3.987205e-38 -2.427574e-04 -2.543763e-04 -2.665949e-04
## ASV0415      5.535393e-39  3.589496e-05  3.760332e-05  3.951705e-05
## ASV10103    -2.427975e-37 -1.455483e-03 -1.523921e-03 -1.595922e-03
## ASV1613      1.905729e-37  1.121165e-03  1.173826e-03  1.228191e-03
## ASV0135     -2.519496e-38 -1.467436e-04 -1.535952e-04 -1.606303e-04
## ASV0469     -2.434666e-37 -1.437605e-03 -1.505082e-03 -1.575070e-03
## ASV0471      1.457385e-37  8.658694e-04  9.066789e-04  9.491206e-04
## ASV0451     -1.973660e-38 -1.260963e-04 -1.323736e-04 -1.390394e-04
## ASV0747      8.198660e-38  4.891168e-04  5.122936e-04  5.363826e-04
## ASV1314     -7.984945e-38 -4.817774e-04 -5.046420e-04 -5.286550e-04
## ASV0425     -3.063841e-37 -1.798405e-03 -1.882781e-03 -1.969769e-03
## ASV0559     -7.382613e-38 -4.371852e-04 -4.578798e-04 -4.792479e-04
## ASV0148     -1.931395e-38 -1.088920e-04 -1.139150e-04 -1.189401e-04
## ASV0129      1.191198e-38  8.197871e-05  8.609986e-05  9.072092e-05
## ASV1072      2.141224e-38  1.234709e-04  1.292125e-04  1.350631e-04
## ASV2390      1.593036e-37  9.302376e-04  9.739339e-04  1.018677e-03
## ASV0548      1.005460e-37  5.966859e-04  6.249110e-04  6.541314e-04
## ASV0168     -5.242578e-38 -3.093973e-04 -3.239474e-04 -3.390039e-04
## ASV0066     -5.861555e-38 -3.468855e-04 -3.632677e-04 -3.802021e-04
## ASV0468     -3.053753e-38 -1.818375e-04 -1.903694e-04 -1.993007e-04
## ASV0172     -1.903764e-38 -1.095500e-04 -1.146270e-04 -1.198056e-04
## ASV0236     -9.992333e-39 -4.488775e-05 -4.660596e-05 -4.802511e-05
## ASV0250      7.571720e-38  4.628165e-04  4.849753e-04  5.083625e-04
## ASV0338      3.718700e-38  2.245425e-04  2.352380e-04  2.464362e-04
## ASV0450     -5.731817e-39 -3.734207e-05 -3.920731e-05 -4.121702e-05
## ASV0377      7.345460e-38  4.342218e-04  4.546515e-04  4.758185e-04
## ASV1022     -3.307092e-39 -1.918509e-05 -2.012309e-05 -2.104068e-05
## ASV6174     -9.332835e-40 -6.886196e-06 -7.217684e-06 -7.624210e-06
## ASV0786     -7.141770e-39 -4.892823e-05 -5.140045e-05 -5.414716e-05
## ASV0053     -7.786690e-38 -4.637098e-04 -4.856406e-04 -5.084320e-04
## ASV0697     -4.907666e-38 -2.884571e-04 -3.020043e-04 -3.159803e-04
## ASV0785      1.016768e-37  6.012013e-04  6.295188e-04  6.588368e-04
## ASV1967     -1.019087e-37 -6.003672e-04 -6.287024e-04 -6.578718e-04
## ASV0385      3.188691e-38  1.931104e-04  2.023293e-04  2.119921e-04
## ASV0295      3.862899e-39  2.741194e-05  2.881195e-05  3.039618e-05
## ASV0072     -7.988702e-38 -4.705554e-04 -4.926491e-04 -5.154958e-04
## ASV0157     -1.300473e-38 -7.072020e-05 -7.389205e-05 -7.700492e-05
## ASV0501      1.676473e-37  9.994465e-04  1.046677e-03  1.095848e-03
## ASV10729    -2.094782e-37 -1.251596e-03 -1.310647e-03 -1.372364e-03
## ASV1470      1.144144e-37  6.668228e-04  6.979273e-04  7.299179e-04
## ASV0050     -1.854993e-37 -1.097961e-03 -1.149643e-03 -1.203241e-03
## ASV0411     -4.009871e-38 -2.411076e-04 -2.525557e-04 -2.645307e-04
## ASV0549      6.511330e-38  3.900188e-04  4.085314e-04  4.278235e-04
## ASV0184      2.252827e-38  1.332424e-04  1.394758e-04  1.459728e-04
## ASV0705      4.510978e-38  2.657024e-04  2.781793e-04  2.910781e-04
## ASV1715      9.267972e-38  5.516787e-04  5.776847e-04  6.047799e-04
## ASV0603      1.411258e-38  8.468011e-05  8.865414e-05  9.284869e-05
## ASV0826      1.582171e-37  9.378959e-04  9.820845e-04  1.027947e-03
## ASV0034     -5.148868e-38 -3.035497e-04 -3.177633e-04 -3.325123e-04
## ASV0838      4.178937e-38  2.335519e-04  2.439219e-04  2.545458e-04
## ASV0614     -4.340930e-38 -2.570851e-04 -2.692118e-04 -2.817717e-04
## ASV0014     -1.144131e-37 -6.791490e-04 -7.111195e-04 -7.443738e-04
## ASV0585      1.826093e-38  9.647831e-05  1.006176e-04  1.046908e-04
## ASV0016     -1.195252e-37 -7.095329e-04 -7.428818e-04 -7.776211e-04
## ASV5394     -8.850160e-38 -5.276811e-04 -5.526070e-04 -5.785732e-04
## ASV0666      2.009595e-37  1.181210e-03  1.236316e-03  1.293511e-03
## ASV2085      5.439281e-38  3.028759e-04  3.164214e-04  3.301607e-04
## ASV0003     -8.157635e-38 -4.841364e-04 -5.068479e-04 -5.305414e-04
## ASV0346      3.905374e-38  2.359203e-04  2.471928e-04  2.589691e-04
## ASV0267     -2.173813e-39 -9.116255e-06 -9.356982e-06 -9.591180e-06
## ASV0353      6.309995e-38  3.788903e-04  3.968319e-04  4.156171e-04
## ASV2419      1.769784e-37  1.047329e-03  1.096401e-03  1.147500e-03
## ASV0447      9.216880e-38  5.542351e-04  5.805225e-04  6.080454e-04
## ASV0654      1.412624e-37  8.390911e-04  8.786045e-04  9.197196e-04
## ASV0151      1.665659e-38  1.034543e-04  1.085482e-04  1.138710e-04
## ASV0065     -5.519710e-38 -3.267339e-04 -3.420816e-04 -3.580309e-04
## ASV0527      1.350566e-37  8.009143e-04  8.384945e-04  8.776610e-04
## ASV4055     -1.974189e-38 -1.203416e-04 -1.261262e-04 -1.321956e-04
## ASV0166     -6.955998e-38 -4.089450e-04 -4.279609e-04 -4.477605e-04
## ASV0417     -2.956752e-38 -1.715149e-04 -1.794565e-04 -1.876376e-04
## ASV0078     -4.090211e-38 -2.411236e-04 -2.523936e-04 -2.641067e-04
## ASV0322     -8.960153e-39 -4.992202e-05 -5.219113e-05 -5.445354e-05
## ASV0156     -9.370606e-38 -5.596779e-04 -5.861120e-04 -6.137043e-04
## ASV0648     -2.023777e-37 -1.211286e-03 -1.268517e-03 -1.328362e-03
## ASV0407     -1.479131e-38 -8.934823e-05 -9.358334e-05 -9.804143e-05
## ASV2030     -3.536766e-38 -2.075585e-04 -2.174554e-04 -2.275109e-04
## ASV0300      2.357716e-38  1.423480e-04  1.491425e-04  1.562439e-04
## ASV1150      4.764031e-39  2.995171e-05  3.143174e-05  3.299024e-05
## ASV0958      7.274455e-38  4.393959e-04  4.603056e-04  4.822347e-04
## ASV0216     -8.582464e-38 -5.066608e-04 -5.303022e-04 -5.549537e-04
## ASV0446      1.246175e-37  7.461772e-04  7.814285e-04  8.183083e-04
## ASV0367     -8.263763e-38 -4.926016e-04 -5.158270e-04 -5.400581e-04
## ASV0200     -4.922115e-38 -2.932591e-04 -3.071086e-04 -3.215282e-04
## ASV0334     -3.027654e-38 -1.727622e-04 -1.805530e-04 -1.886264e-04
## ASV1311      3.526997e-38  2.039794e-04  2.132884e-04  2.229713e-04
## ASV0458      5.285389e-38  3.038410e-04  3.179124e-04  3.322596e-04
## ASV1371      7.091460e-39  4.371276e-05  4.582620e-05  4.805383e-05
## ASV0418      1.145543e-37  6.721964e-04  7.033733e-04  7.358468e-04
## ASV0004      1.669304e-38  9.775465e-05  1.023122e-04  1.070265e-04
## ASV1943      3.422200e-37  1.952453e-03  2.045305e-03  2.136935e-03
## ASV1495     -1.685522e-38 -1.112390e-04 -1.169275e-04 -1.229938e-04
## ASV0901     -9.122558e-38 -5.470751e-04 -5.730404e-04 -6.001376e-04
## ASV0628      5.273977e-38  3.072057e-04  3.213758e-04  3.360889e-04
## ASV0400      3.109193e-38  1.830940e-04  1.916298e-04  2.005104e-04
## ASV0116     -2.688359e-38 -1.611194e-04 -1.687463e-04 -1.767198e-04
## ASV0788      2.370229e-37  1.421841e-03  1.489192e-03  1.559622e-03
## ASV0117      1.692961e-38  1.027255e-04  1.076397e-04  1.127914e-04
## ASV3137     -5.849273e-39 -3.444460e-05 -3.604253e-05 -3.771272e-05
## ASV0001      1.801421e-38  1.053356e-04  1.102138e-04  1.152822e-04
## ASV1651      5.087798e-38  2.983952e-04  3.122584e-04  3.266676e-04
## ASV1692      1.977247e-37  1.185435e-03  1.241582e-03  1.300267e-03
## ASV0660      7.736619e-38  4.492691e-04  4.699192e-04  4.913552e-04
## ASV0508      3.992253e-39  2.292393e-05  2.398614e-05  2.506736e-05
## ASV1660     -3.744589e-38 -2.298139e-04 -2.409097e-04 -2.525737e-04
## ASV0233      6.222044e-38  3.705611e-04  3.879957e-04  4.062027e-04
## ASV1343     -1.129694e-37 -6.764917e-04 -7.085014e-04 -7.419475e-04
## ASV0209      6.012786e-38  3.518096e-04  3.681367e-04  3.850787e-04
## ASV0193     -6.970993e-38 -4.089923e-04 -4.278996e-04 -4.476470e-04
## ASV0357      2.289726e-38  1.420846e-04  1.489842e-04  1.562818e-04
## ASV0198      5.180974e-38  3.061923e-04  3.205042e-04  3.354184e-04
## ASV0007      1.612598e-38  9.384932e-05  9.816925e-05  1.026593e-04
## ASV1772     -2.435500e-38 -1.411582e-04 -1.476780e-04 -1.543975e-04
## ASV0009      1.352346e-38  7.830943e-05  8.188994e-05  8.561368e-05
## ASV0006     -1.303931e-38 -7.892340e-05 -8.271296e-05 -8.666274e-05
## ASV0011     -4.678327e-38 -2.797744e-04 -2.929771e-04 -3.067865e-04
## ASV0015      1.022283e-38  5.918028e-05  6.190726e-05  6.472250e-05
## ASV0017      1.150885e-38  6.664414e-05  6.970346e-05  7.287401e-05
## ASV0235     -4.295050e-38 -2.574590e-04 -2.696528e-04 -2.823945e-04
## ASV0382      3.355335e-38  2.013564e-04  2.109169e-04  2.208925e-04
## ASV2357      1.411664e-37  8.436719e-04  8.834541e-04  9.250672e-04
## ASV0567     -2.716272e-38 -1.626457e-04 -1.703384e-04 -1.783808e-04
## ASV0165      2.354019e-38  1.407231e-04  1.473723e-04  1.543154e-04
## ASV0005      3.483563e-38  2.067897e-04  2.164879e-04  2.266101e-04
## ASV0384     -5.354142e-39 -2.849546e-05 -2.970407e-05 -3.091708e-05
## ASV0002      6.720599e-39  3.943301e-05  4.127994e-05  4.318682e-05
## ASV3017      1.904511e-37  1.117894e-03  1.169777e-03  1.223801e-03
## ASV0091     -4.777808e-39 -2.810281e-05 -2.942548e-05 -3.078931e-05
## ASV0186     -6.984215e-38 -4.153868e-04 -4.349010e-04 -4.552776e-04
## ASV0370      3.767172e-38  2.228121e-04  2.331389e-04  2.439929e-04
## ASV0018      4.449896e-38  2.644329e-04  2.768324e-04  2.897905e-04
## ASV1377      4.584658e-37  2.697920e-03  2.823411e-03  2.954170e-03
## ASV0019      4.664424e-38  2.772830e-04  2.902663e-04  3.038576e-04
## ASV0023     -2.842536e-38 -1.704610e-04 -1.785763e-04 -1.870203e-04
## ASV2194      4.524708e-38  2.722966e-04  2.852289e-04  2.987659e-04
## ASV1155      1.928985e-37  1.130853e-03  1.184678e-03  1.239375e-03
## ASV0510     -5.361231e-38 -3.115241e-04 -3.253373e-04 -3.401732e-04
## ASV2371     -1.159767e-37 -6.806846e-04 -7.128385e-04 -7.457802e-04
## ASV0024     -3.550268e-38 -2.126955e-04 -2.227836e-04 -2.333058e-04
## ASV2452      1.193634e-37  6.957898e-04  7.277183e-04  7.610563e-04
## ASV2332     -3.302952e-37 -1.944731e-03 -2.036378e-03 -2.130801e-03
## ASV2591      7.517177e-38  4.679331e-04  4.900016e-04  5.140271e-04
## ASV0521      7.224752e-38  4.326109e-04  4.530586e-04  4.744433e-04
## ASV5542      6.885571e-38  4.136592e-04  4.328314e-04  4.533111e-04
## ASV0336     -6.841714e-39 -4.508153e-05 -4.736662e-05 -4.981735e-05
## ASV10102     1.277817e-37  7.654269e-04  8.014724e-04  8.393075e-04
## ASV16823    -2.126026e-37 -1.238139e-03 -1.296324e-03 -1.355722e-03
## ASV3104      1.100052e-36  6.406398e-03  6.706984e-03  7.014284e-03
## ASV0781      1.459523e-37  8.667192e-04  9.072450e-04  9.496789e-04
## ASV10899     7.610161e-38  4.725408e-04  4.952506e-04  5.195021e-04
## ASV11222    -3.742099e-37 -2.179294e-03 -2.281447e-03 -2.385978e-03
## ASV11327    -3.359744e-37 -1.956621e-03 -2.048190e-03 -2.142029e-03
## ASV12458    -3.742099e-37 -2.179294e-03 -2.281122e-03 -2.385628e-03
## ASV1636      2.047571e-37  1.207908e-03  1.263819e-03  1.322495e-03
## ASV1890     -1.778896e-37 -1.023608e-03 -1.071256e-03 -1.119688e-03
## ASV2898      2.744464e-37  1.618574e-03  1.693954e-03  1.772593e-03
## ASV8328      1.630693e-38  1.300952e-04  1.370880e-04  1.452445e-04
## ASV0709     -3.018119e-37 -1.789316e-03 -1.872633e-03 -1.960042e-03
## ASV0856      2.392674e-37  1.441905e-03  1.510201e-03  1.581953e-03
## ASV0909      5.978058e-38  3.800739e-04  3.991164e-04  4.191287e-04
## ASV0937     -1.730826e-37 -1.033981e-03 -1.083013e-03 -1.134025e-03
## ASV11390    -5.340841e-37 -3.110357e-03 -3.255460e-03 -3.404605e-03
## ASV11966     1.144392e-37  6.959099e-04  7.289987e-04  7.639523e-04
## ASV12990     9.064135e-38  5.343952e-04  5.588719e-04  5.847845e-04
## ASV14797     1.359248e-37  7.971642e-04  8.339242e-04  8.723911e-04
## ASV14904    -7.663994e-37 -4.463297e-03 -4.671413e-03 -4.885431e-03
## ASV15304     6.870890e-38  4.247617e-04  4.450823e-04  4.667712e-04
## ASV16696    -2.648059e-37 -1.542156e-03 -1.613973e-03 -1.687915e-03
## ASV1690      4.046539e-37  2.443585e-03  2.559658e-03  2.681510e-03
## ASV2029      2.982529e-37  1.764179e-03  1.846491e-03  1.932491e-03
## ASV2834      3.638902e-37  2.172698e-03  2.275059e-03  2.382103e-03
## ASV4003      2.850101e-37  1.731167e-03  1.813661e-03  1.900553e-03
## ASV4064      1.713067e-37  1.026027e-03  1.074330e-03  1.125036e-03
## ASV4294      9.553152e-38  5.890072e-04  6.173414e-04  6.473637e-04
## ASV4609      1.010452e-37  5.985321e-04  6.255660e-04  6.547000e-04
## ASV6283     -2.475375e-37 -1.441589e-03 -1.508756e-03 -1.577882e-03
## ASV6491     -3.547982e-37 -2.066246e-03 -2.162363e-03 -2.261430e-03
## ASV7453      1.508363e-37  9.194136e-04  9.631182e-04  1.009401e-03
## ASV7959      4.836774e-38  3.080012e-04  3.229840e-04  3.391742e-04
## ASV8219      3.066233e-36  1.785688e-02  1.868674e-02  1.954285e-02
## ASV8547     -3.176539e-37 -1.849928e-03 -1.935762e-03 -2.024441e-03
## ASV9319      1.259264e-37  7.580346e-04  7.938387e-04  8.315055e-04
## ASV9382     -6.215338e-37 -3.619639e-03 -3.787417e-03 -3.960919e-03
## ASV11516    -4.151348e-37 -2.417629e-03 -2.529513e-03 -2.645383e-03
## ASV14377    -2.997498e-37 -1.745659e-03 -1.826317e-03 -1.909970e-03
## ASV1867      2.145502e-37  1.284238e-03  1.344794e-03  1.408235e-03
## ASV1895      1.164068e-37  6.795162e-04  7.107382e-04  7.433377e-04
## ASV3168      1.438969e-37  8.448594e-04  8.839174e-04  9.247297e-04
## ASV4449      7.679383e-37  4.551731e-03  4.765102e-03  4.987610e-03
## ASV6596      1.469135e-37  8.970217e-04  9.400955e-04  9.853805e-04
## ASV7492     -4.126145e-38 -2.195226e-04 -2.288157e-04 -2.381842e-04
## ASV9854     -6.526089e-38 -3.774400e-04 -3.948614e-04 -4.128207e-04
## ASV6296      5.030017e-36  2.929341e-02  3.064401e-02  3.204754e-02
## ASV4201      1.026169e-38  8.685832e-05  9.205550e-05  9.773181e-05
## ASV0552      1.490937e-37  8.910832e-04  9.330883e-04  9.770376e-04
## ASV3671     -1.031427e-37 -6.079324e-04 -6.363295e-04 -6.658759e-04
## ASV3529     -3.652550e-38 -1.956160e-04 -2.038236e-04 -2.122475e-04
## ASV1060      3.860869e-38  2.327750e-04  2.438620e-04  2.554597e-04
## ASV0239     -5.819015e-38 -3.383358e-04 -3.539004e-04 -3.700723e-04
## ASV5711     -2.531677e-37 -1.491145e-03 -1.560504e-03 -1.632871e-03
## ASV4152     -3.481160e-37 -2.070563e-03 -2.167781e-03 -2.269375e-03
## ASV1461      1.863685e-37  1.086678e-03  1.136580e-03  1.188668e-03
## ASV2877      9.571357e-38  5.602152e-04  5.860947e-04  6.130690e-04
## ASV0012      1.577765e-38  9.374731e-05  9.815665e-05  1.027518e-04
## ASV9823      2.618292e-38  1.481888e-04  1.547834e-04  1.616280e-04
## ASV0008      1.694051e-38  1.004372e-04  1.051412e-04  1.100513e-04
## ASV7832     -2.042507e-37 -1.215887e-03 -1.272950e-03 -1.332673e-03
## ASV1915     -2.742264e-38 -1.599494e-04 -1.672642e-04 -1.749424e-04
## ASV0055     -1.641800e-38 -1.010925e-04 -1.059864e-04 -1.111361e-04
## ASV0032      9.506820e-39  5.425627e-05  5.667882e-05  5.921232e-05
## ASV2977     -2.898514e-37 -1.722051e-03 -1.802712e-03 -1.887086e-03
## ASV0466      2.465106e-37  1.437289e-03  1.503298e-03  1.572196e-03
## ASV3866      1.550424e-37  9.297521e-04  9.737214e-04  1.019752e-03
## ASV0040      5.692295e-38  3.394567e-04  3.554210e-04  3.721224e-04
## ASV0496     -7.945464e-39 -5.877123e-05 -6.206889e-05 -6.559183e-05
## ASV0052      4.771170e-38  2.847273e-04  2.981012e-04  3.121180e-04
## ASV3828     -1.786474e-37 -1.039703e-03 -1.087322e-03 -1.137072e-03
## ASV1930      8.869797e-38  5.223070e-04  5.466210e-04  5.719488e-04
## ASV2126      1.488711e-37  8.809534e-04  9.220631e-04  9.650255e-04
## ASV0793      1.763401e-37  1.056054e-03  1.105941e-03  1.158146e-03
## ASV0299     -3.419418e-39 -2.041398e-05 -2.136851e-05 -2.237839e-05
## ASV0208      1.289910e-37  7.690081e-04  8.051568e-04  8.429800e-04
## ASV0511     -5.723011e-38 -3.328807e-04 -3.481098e-04 -3.640139e-04
## ASV1123     -1.722502e-37 -1.003009e-03 -1.048982e-03 -1.096989e-03
## ASV0099      4.206423e-39  2.626790e-05  2.756051e-05  2.892067e-05
## ASV0752     -8.851137e-38 -5.345677e-04 -5.600220e-04 -5.866925e-04
## ASV0883      1.219672e-37  7.354348e-04  7.703855e-04  8.070123e-04
## ASV0683      1.611531e-37  9.679840e-04  1.013888e-03  1.061901e-03
## ASV4117     -2.629175e-37 -1.565843e-03 -1.639411e-03 -1.716355e-03
## ASV2172      1.953326e-38  1.114450e-04  1.164520e-04  1.216528e-04
## ASV0330     -4.861720e-38 -2.906564e-04 -3.043633e-04 -3.187047e-04
## ASV0728      2.444617e-37  1.453258e-03  1.521328e-03  1.592557e-03
## ASV0499      6.251727e-38  3.758752e-04  3.937051e-04  4.123694e-04
## ASV0120     -1.082089e-37 -6.436764e-04 -6.738477e-04 -7.054201e-04
## ASV1446      9.369347e-38  5.353076e-04  5.594454e-04  5.845024e-04
## ASV17171    -2.104844e-37 -1.248307e-03 -1.306675e-03 -1.367725e-03
## ASV0533      1.439625e-38  8.796235e-05  9.221258e-05  9.665868e-05
## ASV2495     -4.590535e-38 -2.831938e-04 -2.970048e-04 -3.114800e-04
## ASV5582      1.059913e-37  6.115437e-04  6.392715e-04  6.682151e-04
## ASV1488      3.822586e-38  2.248424e-04  2.352144e-04  2.460959e-04
## ASV0682      4.525921e-38  2.727429e-04  2.857058e-04  2.992824e-04
## ASV0068     -8.159729e-38 -4.860482e-04 -5.088733e-04 -5.327535e-04
## ASV1987     -1.945158e-37 -1.176091e-03 -1.232145e-03 -1.290894e-03
## ASV0035     -1.160925e-38 -7.597101e-05 -7.987604e-05 -8.399370e-05
## ASV7192     -1.300117e-37 -7.667848e-04 -8.024248e-04 -8.396821e-04
## ASV0873      5.556373e-38  1.849835e-04  1.868486e-04  1.879830e-04
## ASV4749      7.244538e-39  2.036600e-05  2.019215e-05  1.991972e-05
## ASV2174      9.567079e-38  5.541191e-04  5.793604e-04  6.057076e-04
## ASV1476     -8.748873e-38 -5.259464e-04 -5.508902e-04 -5.770109e-04
## ASV0740     -2.484042e-37 -1.494086e-03 -1.564987e-03 -1.639208e-03
## ASV0170     -5.002364e-38 -2.979915e-04 -3.119876e-04 -3.266305e-04
## ASV2466     -2.282574e-37 -1.358984e-03 -1.422773e-03 -1.489521e-03
## ASV1709      8.767156e-38  5.134136e-04  5.370921e-04  5.618503e-04
## ASV6170     -3.509325e-37 -2.102768e-03 -2.202137e-03 -2.306152e-03
## ASV3673      1.705017e-37  1.025392e-03  1.074025e-03  1.124955e-03
## ASV1745     -4.242094e-38 -2.586888e-04 -2.711346e-04 -2.841809e-04
##                                                                    
## (Intercept)  8.301571e-03  8.690993e-03  9.098390e-03  9.524565e-03
## ASV1236      1.677899e-03  1.755447e-03  1.836467e-03  1.921104e-03
## ASV0421      1.668480e-04  1.752816e-04  1.841623e-04  1.935154e-04
## ASV0691     -1.355487e-03 -1.416672e-03 -1.480457e-03 -1.546936e-03
## ASV0899      1.448726e-03  1.515870e-03  1.586036e-03  1.659352e-03
## ASV1004      3.351604e-03  3.506771e-03  3.668909e-03  3.838310e-03
## ASV1041     -1.381507e-03 -1.445396e-03 -1.512147e-03 -1.581879e-03
## ASV1058      2.094315e-03  2.191194e-03  2.292418e-03  2.398169e-03
## ASV12542     8.219628e-04  8.596917e-04  8.990848e-04  9.402090e-04
## ASV1294      1.947415e-03  2.037549e-03  2.131730e-03  2.230128e-03
## ASV13113     6.200654e-04  6.496611e-04  6.806725e-04  7.131675e-04
## ASV1318      1.942678e-03  2.032574e-03  2.126503e-03  2.224637e-03
## ASV2269     -3.369228e-03 -3.524991e-03 -3.687728e-03 -3.857732e-03
## ASV2542      1.592493e-03  1.667557e-03  1.746122e-03  1.828349e-03
## ASV2660     -1.344956e-03 -1.407007e-03 -1.471824e-03 -1.539522e-03
## ASV2737      4.760918e-04  4.977397e-04  5.203232e-04  5.438779e-04
## ASV2840      1.815140e-03  1.898245e-03  1.984993e-03  2.075529e-03
## ASV3053      9.237311e-03  9.661694e-03  1.010483e-02  1.056748e-02
## ASV3077      5.879968e-04  6.150422e-04  6.432861e-04  6.727773e-04
## ASV3134      9.986508e-04  1.046048e-03  1.095686e-03  1.147672e-03
## ASV3140      1.381905e-03  1.446649e-03  1.514374e-03  1.585214e-03
## ASV3579      4.676198e-04  4.901911e-04  5.138654e-04  5.386978e-04
## ASV6119     -9.220760e-04 -9.647007e-04 -1.009234e-03 -1.055755e-03
## ASV7557     -1.873733e-03 -1.960343e-03 -2.050830e-03 -2.145356e-03
## ASV8422      4.710377e-04  4.926869e-04  5.152939e-04  5.388975e-04
## ASV1086     -7.699646e-05 -8.042909e-05 -8.400358e-05 -8.772467e-05
## ASV1310      8.968751e-04  9.383619e-04  9.817089e-04  1.026994e-03
## ASV15750    -1.258283e-04 -1.315376e-04 -1.374920e-04 -1.437008e-04
## ASV16905    -3.853032e-04 -4.031130e-04 -4.217202e-04 -4.411579e-04
## ASV2033      1.589292e-03  1.664515e-03  1.743275e-03  1.825737e-03
## ASV2089      8.120216e-04  8.495698e-04  8.888001e-04  9.297830e-04
## ASV2127      2.636215e-03  2.758141e-03  2.885534e-03  3.018621e-03
## ASV2725      2.125545e-03  2.223348e-03  2.325487e-03  2.432139e-03
## ASV2804     -7.976039e-04 -8.344699e-04 -8.729860e-04 -9.132212e-04
## ASV3075      1.723202e-03  1.803614e-03  1.887702e-03  1.975626e-03
## ASV3327      2.352117e-03  2.462897e-03  2.578835e-03  2.700165e-03
## ASV3342      2.028752e-03  2.124065e-03  2.223795e-03  2.328139e-03
## ASV3532     -2.251955e-03 -2.357319e-03 -2.467523e-03 -2.582781e-03
## ASV3600      1.044226e-03  1.093164e-03  1.144357e-03  1.197907e-03
## ASV4013      1.968935e-03  2.060546e-03  2.156318e-03  2.256427e-03
## ASV4136      2.131895e-03  2.230038e-03  2.332539e-03  2.439576e-03
## ASV4195      8.141603e-03  8.517878e-03  8.910992e-03  9.321649e-03
## ASV4407     -3.145544e-03 -3.290908e-03 -3.442776e-03 -3.601420e-03
## ASV4717      5.632933e-04  5.888148e-04  6.154300e-04  6.431800e-04
## ASV6794      1.320844e-03  1.381313e-03  1.444434e-03  1.510313e-03
## ASV8324     -1.614045e-03 -1.688635e-03 -1.766562e-03 -1.847966e-03
## ASV8981     -4.996651e-05 -5.196024e-05 -5.401262e-05 -5.612316e-05
## ASV9859      5.212204e-04  5.465244e-04  5.730789e-04  6.009479e-04
## ASV0936      1.528148e-03  1.600001e-03  1.675187e-03  1.753857e-03
## ASV12683     1.714293e-06  1.678857e-06  1.631064e-06  1.569333e-06
## ASV1293      1.048167e-03  1.096566e-03  1.147127e-03  1.199941e-03
## ASV13055    -3.200385e-05 -3.325190e-05 -3.453340e-05 -3.584762e-05
## ASV17063    -8.373735e-04 -8.760592e-04 -9.164748e-04 -9.586924e-04
## ASV2228      6.828695e-04  7.144147e-04  7.473704e-04  7.817951e-04
## ASV2769      9.622185e-05  1.010322e-04  1.060927e-04  1.114170e-04
## ASV2803      7.510109e-04  7.853108e-04  8.211070e-04  8.584580e-04
## ASV2896      5.744400e-04  6.015025e-04  6.298266e-04  6.594699e-04
## ASV3062      6.766757e-04  7.091216e-04  7.431329e-04  7.787858e-04
## ASV3107      1.074858e-03  1.125367e-03  1.178217e-03  1.233514e-03
## ASV3265      1.501325e-03  1.570599e-03  1.642963e-03  1.718544e-03
## ASV3666      1.560353e-05  1.629269e-05  1.700939e-05  1.775439e-05
## ASV4497      5.126186e-04  5.363738e-04  5.611983e-04  5.871373e-04
## ASV6914     -7.011746e-05 -7.357941e-05 -7.721775e-05 -8.104195e-05
## ASV0576     -1.825064e-03 -1.908175e-03 -1.994888e-03 -2.085343e-03
## ASV0673      1.966663e-03  2.058055e-03  2.153586e-03  2.253433e-03
## ASV0772      9.095347e-04  9.519054e-04  9.962050e-04  1.042517e-03
## ASV0862      6.009915e-05  6.381431e-05  6.778587e-05  7.203328e-05
## ASV0898      6.884056e-04  7.210823e-04  7.553043e-04  7.911439e-04
## ASV0910      8.033070e-04  8.411359e-04  8.807261e-04  9.221575e-04
## ASV0964     -6.855565e-04 -7.169275e-04 -7.496724e-04 -7.838456e-04
## ASV10059     5.621160e-04  5.889059e-04  6.169732e-04  6.463789e-04
## ASV10263    -1.274993e-03 -1.333923e-03 -1.395490e-03 -1.459805e-03
## ASV1088      1.439707e-03  1.507242e-03  1.577899e-03  1.651815e-03
## ASV1101      1.825358e-03  1.909642e-03  1.997691e-03  2.089661e-03
## ASV1183      4.737944e-04  4.959611e-04  5.191461e-04  5.433943e-04
## ASV11956     4.772485e-04  4.989491e-04  5.215871e-04  5.451984e-04
## ASV12774     3.527923e-05  3.663838e-05  3.803210e-05  3.945925e-05
## ASV1321      2.065642e-03  2.163199e-03  2.265325e-03  2.372229e-03
## ASV13793    -8.791040e-04 -9.197345e-04 -9.621835e-04 -1.006527e-03
## ASV14482     5.928580e-05  6.191135e-05  6.464388e-05  6.748689e-05
## ASV15483     3.526652e-04  3.692614e-04  3.866291e-04  4.048032e-04
## ASV2062      1.672020e-03  1.749735e-03  1.830971e-03  1.915879e-03
## ASV2132      1.344062e-03  1.407241e-03  1.473349e-03  1.542519e-03
## ASV2413      1.301480e-03  1.361681e-03  1.424582e-03  1.490296e-03
## ASV2490      4.050642e-03  4.236551e-03  4.430657e-03  4.633291e-03
## ASV2594      4.927999e-04  5.158531e-04  5.399656e-04  5.651844e-04
## ASV2822     -2.319689e-03 -2.426919e-03 -2.538949e-03 -2.655982e-03
## ASV2863      2.480970e-03  2.595202e-03  2.714508e-03  2.839095e-03
## ASV2910      9.042481e-04  9.460089e-04  9.896360e-04  1.035207e-03
## ASV2980      9.983319e-04  1.044790e-03  1.093358e-03  1.144127e-03
## ASV3307      1.845788e-03  1.931098e-03  2.020225e-03  2.113331e-03
## ASV3474      1.176672e-03  1.232454e-03  1.290868e-03  1.352037e-03
## ASV3502      1.261066e-03  1.319997e-03  1.381628e-03  1.446079e-03
## ASV4236      1.909509e-03  1.996997e-03  2.088328e-03  2.183655e-03
## ASV4842     -1.951028e-04 -2.043867e-04 -2.141107e-04 -2.242953e-04
## ASV4894     -8.791979e-04 -9.198377e-04 -9.622969e-04 -1.006652e-03
## ASV5290      6.832169e-04  7.152947e-04  7.488565e-04  7.839688e-04
## ASV5501      4.207898e-04  4.404331e-04  4.609751e-04  4.824552e-04
## ASV5795      4.584045e-04  4.799496e-04  5.024935e-04  5.260814e-04
## ASV5987     -2.455650e-03 -2.569167e-03 -2.687766e-03 -2.811662e-03
## ASV6267     -2.766984e-03 -2.894882e-03 -3.028507e-03 -3.168096e-03
## ASV6862      1.121417e-03  1.172893e-03  1.226641e-03  1.282751e-03
## ASV7145      4.997413e-04  5.225186e-04  5.462862e-04  5.710826e-04
## ASV7673     -8.791707e-04 -9.198080e-04 -9.622645e-04 -1.006616e-03
## ASV7789      4.080752e-04  4.278245e-04  4.485439e-04  4.702822e-04
## ASV7809      1.892925e-05  2.015151e-05  2.146179e-05  2.286698e-05
## ASV8002     -1.110358e-03 -1.161680e-03 -1.215300e-03 -1.271313e-03
## ASV8205      4.558090e-04  4.771708e-04  4.995173e-04  5.228925e-04
## ASV9155     -2.852844e-04 -2.983754e-04 -3.120433e-04 -3.263113e-04
## ASV9221      9.520716e-05  1.002087e-04  1.054922e-04  1.110751e-04
## ASV9311     -1.781221e-03 -1.863547e-03 -1.949558e-03 -2.039408e-03
## ASV9557     -1.217313e-03 -1.273571e-03 -1.332347e-03 -1.393746e-03
## ASV9936     -2.454841e-03 -2.568282e-03 -2.686800e-03 -2.810605e-03
## ASV1445      1.460472e-03  1.528955e-03  1.600599e-03  1.675543e-03
## ASV4232      5.399460e-04  5.656615e-04  5.926022e-04  6.208265e-04
## ASV6479      1.739644e-04  1.828642e-04  1.922452e-04  2.021353e-04
## ASV0142     -1.062162e-03 -1.111121e-03 -1.162258e-03 -1.215664e-03
## ASV0378      4.595680e-04  4.814759e-04  5.044290e-04  5.284772e-04
## ASV1122      1.408548e-03  1.474758e-03  1.544038e-03  1.616527e-03
## ASV0123     -9.388763e-04 -9.821237e-04 -1.027293e-03 -1.074463e-03
## ASV2064      4.905549e-04  5.128377e-04  5.360803e-04  5.603191e-04
## ASV4459     -7.187421e-05 -7.503529e-05 -7.832275e-05 -8.174044e-05
## ASV0448      3.671641e-04  3.846792e-04  4.030310e-04  4.222593e-04
## ASV0397      8.376788e-04  8.767469e-04  9.175977e-04  9.603089e-04
## ASV0485      9.803331e-04  1.025835e-03  1.073393e-03  1.123094e-03
## ASV1566      1.436107e-03  1.503027e-03  1.572996e-03  1.646144e-03
## ASV1365      1.218627e-03  1.275664e-03  1.335323e-03  1.397719e-03
## ASV1065      1.734410e-03  1.815498e-03  1.900304e-03  1.988994e-03
## ASV0722     -8.878193e-05 -9.298512e-05 -9.738626e-05 -1.019946e-04
## ASV12660    -1.020145e-03 -1.067042e-03 -1.116015e-03 -1.167148e-03
## ASV0223      2.702904e-04  2.828501e-04  2.959787e-04  3.097008e-04
## ASV0229      4.052476e-04  4.243059e-04  4.442492e-04  4.651175e-04
## ASV0877      1.798192e-04  1.879778e-04  1.964863e-04  2.053575e-04
## ASV0983      9.757436e-04  1.020955e-03  1.068201e-03  1.117568e-03
## ASV0626      8.519757e-05  8.977576e-05  9.462018e-05  9.974784e-05
## ASV4146      4.792089e-05  5.015610e-05  5.249252e-05  5.493436e-05
## ASV4175     -1.178921e-03 -1.234284e-03 -1.292209e-03 -1.352812e-03
## ASV2082     -4.945172e-04 -5.188640e-04 -5.444455e-04 -5.713274e-04
## ASV2272      5.631855e-04  5.895690e-04  6.171681e-04  6.460368e-04
## ASV2245     -8.393434e-04 -8.788444e-04 -9.201817e-04 -9.634384e-04
## ASV0590     -4.554364e-04 -4.782376e-04 -5.022287e-04 -5.274757e-04
## ASV0217      1.724989e-05  1.890435e-05  2.071523e-05  2.269700e-05
## ASV0416      6.762066e-04  7.067968e-04  7.386928e-04  7.719428e-04
## ASV1056      8.050423e-04  8.431387e-04  8.830259e-04  9.247867e-04
## ASV7777     -1.151300e-03 -1.205236e-03 -1.261655e-03 -1.320670e-03
## ASV0455      2.074659e-04  2.171607e-04  2.272996e-04  2.379022e-04
## ASV0604      5.262144e-04  5.512372e-04  5.774476e-04  6.049017e-04
## ASV6100     -7.878001e-04 -8.248782e-04 -8.636808e-04 -9.042862e-04
## ASV11359    -1.704619e-03 -1.784514e-03 -1.868092e-03 -1.955517e-03
## ASV6604      2.320782e-04  2.430922e-04  2.546268e-04  2.667066e-04
## ASV5004     -6.090616e-04 -6.375166e-04 -6.672750e-04 -6.983942e-04
## ASV1483     -2.632744e-04 -2.755474e-04 -2.883799e-04 -3.017961e-04
## ASV9773     -7.657274e-04 -8.016786e-04 -8.392935e-04 -8.786465e-04
## ASV4059     -1.850781e-05 -1.873680e-05 -1.891574e-05 -1.903668e-05
## ASV1193      9.337816e-04  9.773567e-04  1.022922e-03  1.070566e-03
## ASV4610     -1.755059e-04 -1.827750e-04 -1.902902e-04 -1.980540e-04
## ASV0742     -1.117961e-04 -1.162743e-04 -1.208870e-04 -1.256335e-04
## ASV1502     -2.746038e-05 -2.920483e-05 -3.107314e-05 -3.307492e-05
## ASV0195      3.158219e-05  3.276593e-05  3.397646e-05  3.521240e-05
## ASV1213      6.805403e-04  7.115755e-04  7.439602e-04  7.777468e-04
## ASV1648     -7.083737e-04 -7.416849e-04 -7.765429e-04 -8.130176e-04
## ASV6984     -6.624295e-04 -6.935894e-04 -7.261971e-04 -7.603183e-04
## ASV0396     -4.797821e-05 -4.989295e-05 -5.186465e-05 -5.389297e-05
## ASV4297      9.775618e-04  1.022444e-03  1.069306e-03  1.118228e-03
## ASV2622      1.499993e-03  1.569365e-03  1.641847e-03  1.717569e-03
## ASV3512      5.463058e-04  5.727468e-04  6.004870e-04  6.295919e-04
## ASV2411      9.869559e-04  1.033704e-03  1.082654e-03  1.133909e-03
## ASV2291     -3.887378e-04 -4.083782e-04 -4.290589e-04 -4.508390e-04
## ASV0807      1.374821e-03  1.438993e-03  1.506099e-03  1.576266e-03
## ASV1292      3.477000e-04  3.634215e-04  3.798137e-04  3.969012e-04
## ASV1035      1.284676e-03  1.343853e-03  1.405661e-03  1.470210e-03
## ASV0070      1.495790e-06  1.864277e-06  2.278292e-06  2.742581e-06
## ASV0255      1.246108e-04  1.302654e-04  1.361628e-04  1.423123e-04
## ASV0057     -3.584258e-04 -3.747867e-04 -3.918601e-04 -4.096739e-04
## ASV0077     -7.959570e-05 -8.311827e-05 -8.678343e-05 -9.059567e-05
## ASV0625      7.426074e-04  7.767341e-04  8.123699e-04  8.495758e-04
## ASV2464      5.068327e-03  5.300654e-03  5.543206e-03  5.796391e-03
## ASV1315      1.282202e-03  1.343058e-03  1.406791e-03  1.473538e-03
## ASV2673      1.098916e-03  1.151102e-03  1.205760e-03  1.263004e-03
## ASV2161      4.657163e-04  4.877966e-04  5.109191e-04  5.351326e-04
## ASV0337     -2.699682e-04 -2.826604e-04 -2.959415e-04 -3.098379e-04
## ASV7680     -1.759088e-03 -1.841875e-03 -1.928510e-03 -2.019169e-03
## ASV0611      9.817116e-04  1.027935e-03  1.076309e-03  1.126933e-03
## ASV3118     -1.004135e-03 -1.051924e-03 -1.101985e-03 -1.154426e-03
## ASV1284      4.288515e-04  4.468907e-04  4.655656e-04  4.848860e-04
## ASV0889      7.592570e-04  7.944441e-04  8.312160e-04  8.696397e-04
## ASV4649     -3.752951e-04 -3.928579e-04 -4.112278e-04 -4.304406e-04
## ASV1108     -7.456424e-04 -7.813128e-04 -8.186970e-04 -8.578778e-04
## ASV0738      3.984376e-04  4.179600e-04  4.384634e-04  4.599992e-04
## ASV0473     -7.511292e-05 -7.900937e-05 -8.312049e-05 -8.745906e-05
## ASV0598     -1.987660e-04 -2.086710e-04 -2.190891e-04 -2.300487e-04
## ASV0429      5.678454e-04  5.940287e-04  6.213778e-04  6.499405e-04
## ASV1549      1.013112e-03  1.061251e-03  1.111673e-03  1.164484e-03
## ASV1203      8.236281e-04  8.618760e-04  9.018533e-04  9.436340e-04
## ASV4532      3.968088e-05  4.137597e-05  4.313398e-05  4.495634e-05
## ASV0274      1.355758e-04  1.421407e-04  1.490280e-04  1.562540e-04
## ASV0163     -6.466617e-04 -6.763271e-04 -7.072995e-04 -7.396314e-04
## ASV1298      7.486872e-05  7.815824e-05  8.157925e-05  8.513578e-05
## ASV9424     -1.360289e-03 -1.424415e-03 -1.491534e-03 -1.561782e-03
## ASV0412      1.433986e-03  1.500396e-03  1.569792e-03  1.642301e-03
## ASV0284      3.133943e-04  3.274477e-04  3.420888e-04  3.573382e-04
## ASV0620     -2.722679e-04 -2.856216e-04 -2.996472e-04 -3.143801e-04
## ASV0153     -1.354584e-03 -1.418950e-03 -1.486368e-03 -1.556980e-03
## ASV0498      4.836094e-04  5.063955e-04  5.302431e-04  5.552004e-04
## ASV0097      2.662307e-04  2.788750e-04  2.921182e-04  3.059885e-04
## ASV0104     -1.931449e-03 -2.021446e-03 -2.115541e-03 -2.213912e-03
## ASV1282      6.770957e-04  7.082703e-04  7.408284e-04  7.748262e-04
## ASV3883     -5.057419e-04 -5.301450e-04 -5.557393e-04 -5.825841e-04
## ASV0801      2.581840e-04  2.703389e-04  2.830592e-04  2.963703e-04
## ASV1611     -1.213287e-03 -1.270706e-03 -1.330825e-03 -1.393769e-03
## ASV0227     -2.042853e-04 -2.144810e-04 -2.252055e-04 -2.364878e-04
## ASV0833      4.165167e-04  4.360930e-04  4.565767e-04  4.780087e-04
## ASV0718      1.868418e-03  1.956035e-03  2.047695e-03  2.143581e-03
## ASV1139      2.639387e-04  2.755135e-04  2.875461e-04  3.000496e-04
## ASV0766     -2.509301e-04 -2.630609e-04 -2.757857e-04 -2.891342e-04
## ASV2091      1.558500e-03  1.630160e-03  1.704993e-03  1.783126e-03
## ASV1238     -1.378498e-03 -1.443511e-03 -1.511560e-03 -1.582785e-03
## ASV9193     -1.139840e-04 -1.200026e-04 -1.263634e-04 -1.330879e-04
## ASV0290      2.123471e-04  2.217954e-04  2.316318e-04  2.418694e-04
## ASV0231      5.644681e-04  5.906127e-04  6.179331e-04  6.464787e-04
## ASV0185      3.065003e-04  3.214886e-04  3.372274e-04  3.537558e-04
## ASV2330      6.582021e-04  6.882957e-04  7.197049e-04  7.524815e-04
## ASV3119     -2.785499e-04 -2.921356e-04 -3.063981e-04 -3.213725e-04
## ASV2368     -7.002598e-04 -7.335433e-04 -7.684062e-04 -8.049230e-04
## ASV0122     -3.491884e-04 -3.654188e-04 -3.823847e-04 -4.001174e-04
## ASV1044      8.739917e-04  9.153593e-04  9.586727e-04  1.004022e-03
## ASV0160     -3.827994e-04 -4.003125e-04 -4.185924e-04 -4.376694e-04
## ASV0326      9.750052e-05  1.020902e-04  1.068933e-04  1.119193e-04
## ASV1388      1.807665e-03  1.891829e-03  1.979819e-03  2.071800e-03
## ASV0792      1.356358e-03  1.418976e-03  1.484390e-03  1.552716e-03
## ASV0036     -4.061160e-04 -4.254237e-04 -4.456473e-04 -4.668300e-04
## ASV2125      1.288241e-03  1.348359e-03  1.411224e-03  1.476955e-03
## ASV1075     -1.947045e-05 -2.037334e-05 -2.131714e-05 -2.230365e-05
## ASV0390      6.712021e-04  7.030830e-04  7.364743e-04  7.714472e-04
## ASV3790     -9.657192e-04 -1.011145e-03 -1.058681e-03 -1.108422e-03
## ASV1535     -2.666695e-04 -2.796310e-04 -2.932341e-04 -3.075118e-04
## ASV0263      1.190547e-03  1.246275e-03  1.304566e-03  1.365532e-03
## ASV0675      1.769255e-03  1.852763e-03  1.940176e-03  2.031674e-03
## ASV3348      1.396208e-04  1.463460e-04  1.533983e-04  1.607941e-04
## ASV0058     -5.354625e-04 -5.603645e-04 -5.863958e-04 -6.136050e-04
## ASV4142      7.591955e-04  7.942308e-04  8.308283e-04  8.690526e-04
## ASV0059     -4.327884e-04 -4.528652e-04 -4.738478e-04 -4.957747e-04
## ASV0013     -7.607525e-04 -7.963398e-04 -8.335610e-04 -8.724884e-04
## ASV0033     -3.536846e-04 -3.704752e-04 -3.880602e-04 -4.064767e-04
## ASV4354     -4.480561e-04 -4.690086e-04 -4.909232e-04 -5.138426e-04
## ASV0022     -2.988524e-04 -3.130330e-04 -3.278838e-04 -3.434363e-04
## ASV0134     -2.794035e-04 -2.928325e-04 -3.069124e-04 -3.216751e-04
## ASV0415      4.153173e-05  4.365443e-05  4.589135e-05  4.824907e-05
## ASV10103    -1.671292e-03 -1.750191e-03 -1.832782e-03 -1.919234e-03
## ASV1613      1.285004e-03  1.344364e-03  1.406378e-03  1.471156e-03
## ASV0135     -1.679742e-04 -1.756390e-04 -1.836374e-04 -1.919822e-04
## ASV0469     -1.648234e-03 -1.724709e-03 -1.804637e-03 -1.888163e-03
## ASV0471      9.935132e-04  1.039943e-03  1.088501e-03  1.139280e-03
## ASV0451     -1.460559e-04 -1.534434e-04 -1.612229e-04 -1.694167e-04
## ASV0747      5.615896e-04  5.879648e-04  6.155609e-04  6.444328e-04
## ASV1314     -5.538089e-04 -5.801587e-04 -6.077611e-04 -6.366756e-04
## ASV0425     -2.060655e-03 -2.155595e-03 -2.254756e-03 -2.358311e-03
## ASV0559     -5.015963e-04 -5.249649e-04 -5.493983e-04 -5.749428e-04
## ASV0148     -1.241670e-04 -1.296017e-04 -1.352501e-04 -1.411182e-04
## ASV0129      9.561099e-05  1.007876e-04  1.062694e-04  1.120764e-04
## ASV1072      1.411646e-04  1.475255e-04  1.541550e-04  1.610630e-04
## ASV2390      1.065401e-03  1.114181e-03  1.165099e-03  1.218240e-03
## ASV0548      6.846942e-04  7.166568e-04  7.500807e-04  7.850296e-04
## ASV0168     -3.547425e-04 -3.711925e-04 -3.883840e-04 -4.063486e-04
## ASV0066     -3.979093e-04 -4.164220e-04 -4.357748e-04 -4.560041e-04
## ASV0468     -2.086446e-04 -2.184196e-04 -2.286449e-04 -2.393406e-04
## ASV0172     -1.252041e-04 -1.308309e-04 -1.366940e-04 -1.428017e-04
## ASV0236     -4.943609e-05 -5.083203e-05 -5.220460e-05 -5.354443e-05
## ASV0250      5.328918e-04  5.586192e-04  5.856047e-04  6.139112e-04
## ASV0338      2.581662e-04  2.704535e-04  2.833245e-04  2.968067e-04
## ASV0450     -4.333452e-05 -4.556730e-05 -4.792215e-05 -5.040630e-05
## ASV0377      4.979499e-04  5.210854e-04  5.452682e-04  5.705431e-04
## ASV1022     -2.199809e-05 -2.299665e-05 -2.403786e-05 -2.512328e-05
## ASV6174     -8.060284e-06 -8.524194e-06 -9.018097e-06 -9.544198e-06
## ASV0786     -5.704847e-05 -6.011776e-05 -6.336562e-05 -6.680344e-05
## ASV0053     -5.322774e-04 -5.572236e-04 -5.833195e-04 -6.106165e-04
## ASV0697     -3.305844e-04 -3.458424e-04 -3.617817e-04 -3.784303e-04
## ASV0785      6.894900e-04  7.215347e-04  7.550309e-04  7.900408e-04
## ASV1967     -6.883678e-04 -7.202381e-04 -7.535412e-04 -7.883377e-04
## ASV0385      2.221174e-04  2.327272e-04  2.438448e-04  2.554946e-04
## ASV0295      3.207547e-05  3.385656e-05  3.574632e-05  3.775212e-05
## ASV0072     -5.393724e-04 -5.643225e-04 -5.903911e-04 -6.176252e-04
## ASV0157     -8.022816e-05 -8.356298e-05 -8.701079e-05 -9.057272e-05
## ASV0501      1.147304e-03  1.201141e-03  1.257465e-03  1.316389e-03
## ASV10729    -1.436955e-03 -1.504550e-03 -1.575283e-03 -1.649299e-03
## ASV1470      7.633158e-04  7.981759e-04  8.345560e-04  8.725156e-04
## ASV0050     -1.259283e-03 -1.317875e-03 -1.379128e-03 -1.443154e-03
## ASV0411     -2.770695e-04 -2.901998e-04 -3.039491e-04 -3.183462e-04
## ASV0549      4.480193e-04  4.691599e-04  4.912886e-04  5.144508e-04
## ASV0184      1.527666e-04  1.598692e-04  1.672940e-04  1.750550e-04
## ASV0705      3.045599e-04  3.186477e-04  3.333671e-04  3.487445e-04
## ASV1715      6.331264e-04  6.627797e-04  6.937980e-04  7.262419e-04
## ASV0603      9.724035e-05  1.018385e-04  1.066529e-04  1.116935e-04
## ASV0826      1.075910e-03  1.126064e-03  1.178504e-03  1.233329e-03
## ASV0034     -3.479271e-04 -3.640363e-04 -3.808692e-04 -3.984563e-04
## ASV0838      2.655819e-04  2.770408e-04  2.889328e-04  3.012681e-04
## ASV0614     -2.949073e-04 -3.086419e-04 -3.230015e-04 -3.380132e-04
## ASV0014     -7.791543e-04 -8.155278e-04 -8.535643e-04 -8.933366e-04
## ASV0585      1.088923e-04  1.132203e-04  1.176742e-04  1.222526e-04
## ASV0016     -8.139544e-04 -8.519519e-04 -8.916865e-04 -9.332344e-04
## ASV5394     -6.057433e-04 -6.341709e-04 -6.639126e-04 -6.950271e-04
## ASV0666      1.353272e-03  1.415706e-03  1.480924e-03  1.549041e-03
## ASV2085      3.444301e-04  3.592429e-04  3.746126e-04  3.905520e-04
## ASV0003     -5.553211e-04 -5.812350e-04 -6.083327e-04 -6.366659e-04
## ASV0346      2.713066e-04  2.842317e-04  2.977722e-04  3.119575e-04
## ASV0267     -9.814350e-06 -1.002610e-05 -1.022381e-05 -1.040455e-05
## ASV0353      4.352868e-04  4.558815e-04  4.774440e-04  5.000192e-04
## ASV2419      1.200926e-03  1.256782e-03  1.315171e-03  1.376204e-03
## ASV0447      6.368663e-04  6.670464e-04  6.986492e-04  7.317409e-04
## ASV0654      9.627250e-04  1.007703e-03  1.054741e-03  1.103929e-03
## ASV0151      1.194635e-04  1.253384e-04  1.315105e-04  1.379958e-04
## ASV0065     -3.747070e-04 -3.921419e-04 -4.103685e-04 -4.294208e-04
## ASV0527      9.186209e-04  9.614523e-04  1.006237e-03  1.053060e-03
## ASV4055     -1.385603e-04 -1.452349e-04 -1.522348e-04 -1.595763e-04
## ASV0166     -4.684480e-04 -4.900610e-04 -5.126377e-04 -5.362181e-04
## ASV0417     -1.961738e-04 -2.050789e-04 -2.143670e-04 -2.240527e-04
## ASV0078     -2.763479e-04 -2.891402e-04 -3.025070e-04 -3.164722e-04
## ASV0322     -5.680309e-05 -5.924092e-05 -6.176897e-05 -6.438905e-05
## ASV0156     -6.425812e-04 -6.728004e-04 -7.044228e-04 -7.375119e-04
## ASV0648     -1.391005e-03 -1.456571e-03 -1.525196e-03 -1.597019e-03
## ASV0407     -1.027118e-04 -1.076047e-04 -1.127308e-04 -1.181011e-04
## ASV2030     -2.380289e-04 -2.490190e-04 -2.605017e-04 -2.724976e-04
## ASV0300      1.636840e-04  1.714782e-04  1.796433e-04  1.881970e-04
## ASV1150      3.462869e-05  3.635139e-05  3.816291e-05  4.006808e-05
## ASV0958      5.052090e-04  5.292783e-04  5.544947e-04  5.809129e-04
## ASV0216     -5.807225e-04 -6.076570e-04 -6.358070e-04 -6.652241e-04
## ASV0446      8.569114e-04  8.973178e-04  9.396098e-04  9.838736e-04
## ASV0367     -5.654115e-04 -5.919378e-04 -6.196894e-04 -6.487213e-04
## ASV0200     -3.366150e-04 -3.523990e-04 -3.689113e-04 -3.861844e-04
## ASV0334     -1.970351e-04 -2.057907e-04 -2.149048e-04 -2.243892e-04
## ASV1311      2.330719e-04  2.436048e-04  2.545861e-04  2.660322e-04
## ASV0458      3.472231e-04  3.628188e-04  3.790697e-04  3.959991e-04
## ASV1371      5.039140e-05  5.284470e-05  5.541961e-05  5.812233e-05
## ASV0418      7.697709e-04  8.052054e-04  8.422127e-04  8.808571e-04
## ASV0004      1.119504e-04  1.170925e-04  1.224618e-04  1.280674e-04
## ASV1943      2.232515e-03  2.332076e-03  2.435756e-03  2.543698e-03
## ASV1495     -1.293953e-04 -1.361528e-04 -1.432880e-04 -1.508239e-04
## ASV0901     -6.285070e-04 -6.582076e-04 -6.893010e-04 -7.218515e-04
## ASV0628      3.514472e-04  3.674758e-04  3.842011e-04  4.016500e-04
## ASV0400      2.097910e-04  2.194881e-04  2.296192e-04  2.402022e-04
## ASV0116     -1.850666e-04 -1.938045e-04 -2.029514e-04 -2.125260e-04
## ASV0788      1.633363e-03  1.710564e-03  1.791387e-03  1.875999e-03
## ASV0117      1.181914e-04  1.238513e-04  1.297835e-04  1.360013e-04
## ASV3137     -3.945820e-05 -4.128204e-05 -4.318755e-05 -4.517813e-05
## ASV0001      1.205752e-04  1.261017e-04  1.318711e-04  1.378932e-04
## ASV1651      3.417196e-04  3.574410e-04  3.738591e-04  3.910026e-04
## ASV1692      1.361705e-03  1.426023e-03  1.493354e-03  1.563836e-03
## ASV0660      5.137240e-04  5.370607e-04  5.614023e-04  5.867870e-04
## ASV0508      2.619495e-05  2.737008e-05  2.859446e-05  2.986982e-05
## ASV1660     -2.648101e-04 -2.776482e-04 -2.911184e-04 -3.052524e-04
## ASV0233      4.252519e-04  4.451803e-04  4.660273e-04  4.878337e-04
## ASV1343     -7.769589e-04 -8.136072e-04 -8.519674e-04 -8.921181e-04
## ASV0209      4.027732e-04  4.212498e-04  4.405401e-04  4.606768e-04
## ASV0193     -4.682757e-04 -4.898219e-04 -5.123233e-04 -5.358187e-04
## ASV0357      1.639462e-04  1.719968e-04  1.804538e-04  1.893387e-04
## ASV0198      3.510105e-04  3.673091e-04  3.843447e-04  4.021486e-04
## ASV0007      1.073460e-04  1.122370e-04  1.173401e-04  1.226635e-04
## ASV1772     -1.614067e-04 -1.687169e-04 -1.763390e-04 -1.842845e-04
## ASV0009      8.949844e-05  9.355015e-05  9.777510e-05  1.021797e-04
## ASV0006     -9.080197e-05 -9.513942e-05 -9.968464e-05 -1.044476e-04
## ASV0011     -3.212396e-04 -3.363662e-04 -3.521967e-04 -3.687634e-04
## ASV0015      6.765923e-05  7.072214e-05  7.391596e-05  7.724557e-05
## ASV0017      7.618138e-05  7.963096e-05  8.322811e-05  8.697832e-05
## ASV0235     -2.957335e-04 -3.096972e-04 -3.243144e-04 -3.396149e-04
## ASV0382      2.313368e-04  2.422709e-04  2.537173e-04  2.656995e-04
## ASV2357      9.686186e-04  1.014197e-03  1.061893e-03  1.111804e-03
## ASV0567     -1.868002e-04 -1.956137e-04 -2.048394e-04 -2.144963e-04
## ASV0165      1.615824e-04  1.691877e-04  1.771466e-04  1.854752e-04
## ASV0005      2.371963e-04  2.482672e-04  2.598439e-04  2.719486e-04
## ASV0384     -3.216869e-05 -3.345907e-05 -3.478813e-05 -3.615559e-05
## ASV0002      4.517896e-05  4.725994e-05  4.943346e-05  5.170331e-05
## ASV3017      1.280235e-03  1.339183e-03  1.400748e-03  1.465037e-03
## ASV0091     -3.221452e-05 -3.370385e-05 -3.526001e-05 -3.688581e-05
## ASV0186     -4.765925e-04 -4.988876e-04 -5.222063e-04 -5.465939e-04
## ASV0370      2.553382e-04  2.671977e-04  2.795936e-04  2.925487e-04
## ASV0018      3.033439e-04  3.175194e-04  3.323443e-04  3.478471e-04
## ASV1377      3.090808e-03  3.233572e-03  3.382718e-03  3.538512e-03
## ASV0019      3.180738e-04  3.329428e-04  3.484936e-04  3.647561e-04
## ASV0023     -1.958610e-04 -2.051165e-04 -2.148058e-04 -2.249489e-04
## ASV2194      3.129435e-04  3.277916e-04  3.433418e-04  3.596269e-04
## ASV1155      1.296554e-03  1.356284e-03  1.418673e-03  1.483830e-03
## ASV0510     -3.556404e-04 -3.717751e-04 -3.886023e-04 -4.061480e-04
## ASV2371     -7.802117e-04 -8.161818e-04 -8.537548e-04 -8.929971e-04
## ASV0024     -2.443210e-04 -2.558516e-04 -2.679214e-04 -2.805550e-04
## ASV2452      7.958546e-04  8.321738e-04  8.700737e-04  9.096159e-04
## ASV2332     -2.229512e-03 -2.332667e-03 -2.440453e-03 -2.553066e-03
## ASV2591      5.392359e-04  5.657105e-04  5.935164e-04  6.227228e-04
## ASV0521      4.968282e-04  5.202594e-04  5.447846e-04  5.704540e-04
## ASV5542      4.747422e-04  4.971779e-04  5.206644e-04  5.452497e-04
## ASV0336     -5.240307e-05 -5.513169e-05 -5.801182e-05 -6.105261e-05
## ASV10102     8.789102e-04  9.203634e-04  9.637519e-04  1.009164e-03
## ASV16823    -1.417759e-03 -1.482515e-03 -1.550101e-03 -1.620626e-03
## ASV3104      7.335229e-03  7.670242e-03  8.019884e-03  8.384734e-03
## ASV0781      9.940573e-04  1.040469e-03  1.089003e-03  1.139752e-03
## ASV10899     5.449618e-04  5.717004e-04  5.997845e-04  6.292848e-04
## ASV11222    -2.495145e-03 -2.609098e-03 -2.728027e-03 -2.852127e-03
## ASV11327    -2.240028e-03 -2.342322e-03 -2.449081e-03 -2.560482e-03
## ASV12458    -2.494763e-03 -2.608680e-03 -2.727570e-03 -2.851628e-03
## ASV1636      1.383811e-03  1.447888e-03  1.514846e-03  1.584803e-03
## ASV1890     -1.170212e-03 -1.222883e-03 -1.277781e-03 -1.334986e-03
## ASV2898      1.854785e-03  1.940682e-03  2.030441e-03  2.124223e-03
## ASV8328      1.539283e-04  1.631894e-04  1.730700e-04  1.836155e-04
## ASV0709     -2.051437e-03 -2.146999e-03 -2.246908e-03 -2.351354e-03
## ASV0856      1.657099e-03  1.735804e-03  1.818236e-03  1.904569e-03
## ASV0909      4.401909e-04  4.623591e-04  4.856954e-04  5.102656e-04
## ASV0937     -1.187418e-03 -1.243298e-03 -1.301777e-03 -1.362974e-03
## ASV11390    -3.560344e-03 -3.722907e-03 -3.892564e-03 -4.069596e-03
## ASV11966     8.005860e-04  8.389863e-04  8.792390e-04  9.214340e-04
## ASV12990     6.118550e-04  6.401401e-04  6.696906e-04  7.005591e-04
## ASV14797     9.125693e-04  9.545321e-04  9.983526e-04  1.044106e-03
## ASV14904    -5.108904e-03 -5.342167e-03 -5.585611e-03 -5.839636e-03
## ASV15304     4.895329e-04  5.134268e-04  5.385109e-04  5.648462e-04
## ASV16696    -1.765120e-03 -1.845707e-03 -1.929811e-03 -2.017571e-03
## ASV1690      2.809146e-03  2.942848e-03  3.082902e-03  3.229608e-03
## ASV2029      2.022404e-03  2.116399e-03  2.214653e-03  2.317348e-03
## ASV2834      2.494122e-03  2.611341e-03  2.733994e-03  2.862327e-03
## ASV4003      1.991625e-03  2.087086e-03  2.187148e-03  2.292038e-03
## ASV4064      1.178111e-03  1.233665e-03  1.291811e-03  1.352668e-03
## ASV4294      6.788699e-04  7.119388e-04  7.466505e-04  7.830891e-04
## ASV4609      6.851466e-04  7.169731e-04  7.502383e-04  7.850037e-04
## ASV6283     -1.650057e-03 -1.725393e-03 -1.804018e-03 -1.886060e-03
## ASV6491     -2.364863e-03 -2.472828e-03 -2.585503e-03 -2.703074e-03
## ASV7453      1.057921e-03  1.108791e-03  1.162127e-03  1.218050e-03
## ASV7959      3.562068e-04  3.741315e-04  3.929978e-04  4.128584e-04
## ASV8219      2.043667e-02  2.136963e-02  2.234330e-02  2.335928e-02
## ASV8547     -2.117025e-03 -2.213662e-03 -2.314516e-03 -2.419751e-03
## ASV9319      8.709508e-04  9.122592e-04  9.555177e-04  1.000817e-03
## ASV9382     -4.142054e-03 -4.331121e-03 -4.528435e-03 -4.734320e-03
## ASV11516    -2.766349e-03 -2.892611e-03 -3.024379e-03 -3.161870e-03
## ASV14377    -1.997301e-03 -2.088454e-03 -2.183583e-03 -2.282842e-03
## ASV1867      1.474639e-03  1.544142e-03  1.616886e-03  1.693019e-03
## ASV1895      7.773706e-04  8.128941e-04  8.499671e-04  8.886500e-04
## ASV3168      9.673626e-04  1.011892e-03  1.058396e-03  1.106954e-03
## ASV4449      5.220303e-03  5.463629e-03  5.718051e-03  5.984054e-03
## ASV6596      1.032870e-03  1.082673e-03  1.134904e-03  1.189685e-03
## ASV7492     -2.478579e-04 -2.578382e-04 -2.681259e-04 -2.787205e-04
## ASV9854     -4.315582e-04 -4.511036e-04 -4.714880e-04 -4.927431e-04
## ASV6296      3.351272e-02  3.504204e-02  3.663802e-02  3.830329e-02
## ASV4201      1.037986e-04  1.102851e-04  1.172231e-04  1.246469e-04
## ASV0552      1.023034e-03  1.071169e-03  1.121542e-03  1.174252e-03
## ASV3671     -6.967598e-04 -7.290388e-04 -7.627727e-04 -7.980235e-04
## ASV3529     -2.209543e-04 -2.299474e-04 -2.392290e-04 -2.488008e-04
## ASV1060      2.676085e-04  2.803343e-04  2.936647e-04  3.076282e-04
## ASV0239     -3.869501e-04 -4.045618e-04 -4.229359e-04 -4.421017e-04
## ASV5711     -1.708501e-03 -1.787535e-03 -1.870118e-03 -1.956397e-03
## ASV4152     -2.375652e-03 -2.486823e-03 -2.603104e-03 -2.724722e-03
## ASV1461      1.243043e-03  1.299799e-03  1.359028e-03  1.420827e-03
## ASV2877      6.412393e-04  6.706541e-04  7.013638e-04  7.334203e-04
## ASV0012      1.075583e-04  1.125855e-04  1.178431e-04  1.233415e-04
## ASV9823      1.687485e-04  1.761535e-04  1.838513e-04  1.918504e-04
## ASV0008      1.151861e-04  1.205555e-04  1.261697e-04  1.320394e-04
## ASV7832     -1.395156e-03 -1.460524e-03 -1.528907e-03 -1.600440e-03
## ASV1915     -1.829600e-04 -1.913313e-04 -2.000705e-04 -2.091927e-04
## ASV0055     -1.165407e-04 -1.222131e-04 -1.281670e-04 -1.344169e-04
## ASV0032      6.185089e-05  6.459819e-05  6.745785e-05  7.043354e-05
## ASV2977     -1.975341e-03 -2.067646e-03 -2.164183e-03 -2.265136e-03
## ASV0466      1.644122e-03  1.719196e-03  1.797545e-03  1.879295e-03
## ASV3866      1.067942e-03  1.118391e-03  1.171204e-03  1.226489e-03
## ASV0040      3.895978e-04  4.078821e-04  4.270118e-04  4.470246e-04
## ASV0496     -6.933581e-05 -7.331605e-05 -7.754910e-05 -8.205276e-05
## ASV0052      3.267852e-04  3.421322e-04  3.581897e-04  3.749895e-04
## ASV3828     -1.189002e-03 -1.243200e-03 -1.299755e-03 -1.358758e-03
## ASV1930      5.984157e-04  6.260697e-04  6.549604e-04  6.851392e-04
## ASV2126      1.009944e-03  1.056904e-03  1.105993e-03  1.157303e-03
## ASV0793      1.212794e-03  1.269995e-03  1.329867e-03  1.392533e-03
## ASV0299     -2.343605e-05 -2.454389e-05 -2.570434e-05 -2.692002e-05
## ASV0208      8.825554e-04  9.239617e-04  9.672811e-04  1.012599e-03
## ASV0511     -3.806117e-04 -3.979303e-04 -4.159974e-04 -4.348418e-04
## ASV1123     -1.147100e-03 -1.199398e-03 -1.253969e-03 -1.310901e-03
## ASV0099      3.035020e-05  3.185291e-05  3.343278e-05  3.509402e-05
## ASV0752     -6.146325e-04 -6.439022e-04 -6.745649e-04 -7.066866e-04
## ASV0883      8.453767e-04  8.855609e-04  9.276506e-04  9.717356e-04
## ASV0683      1.112174e-03  1.164813e-03  1.219926e-03  1.277630e-03
## ASV4117     -1.796857e-03 -1.881078e-03 -1.969185e-03 -2.061350e-03
## ASV2172      1.270687e-04  1.327067e-04  1.385741e-04  1.446783e-04
## ASV0330     -3.337146e-04 -3.494233e-04 -3.658629e-04 -3.830663e-04
## ASV0728      1.667061e-03  1.744985e-03  1.826481e-03  1.911705e-03
## ASV0499      4.319145e-04  4.523814e-04  4.738132e-04  4.962550e-04
## ASV0120     -7.384467e-04 -7.729921e-04 -8.091235e-04 -8.469109e-04
## ASV1446      6.106046e-04  6.377888e-04  6.660917e-04  6.955508e-04
## ASV17171    -1.431573e-03 -1.498342e-03 -1.568160e-03 -1.641162e-03
## ASV0533      1.013217e-04  1.062122e-04  1.113417e-04  1.167220e-04
## ASV2495     -3.266766e-04 -3.426322e-04 -3.593862e-04 -3.769805e-04
## ASV5582      6.983959e-04  7.298601e-04  7.626546e-04  7.968276e-04
## ASV1488      2.574652e-04  2.693426e-04  2.817494e-04  2.947071e-04
## ASV0682      3.135028e-04  3.283970e-04  3.439970e-04  3.603360e-04
## ASV0068     -5.577372e-04 -5.838739e-04 -6.112150e-04 -6.398140e-04
## ASV1987     -1.352447e-03 -1.416936e-03 -1.484503e-03 -1.555293e-03
## ASV0035     -8.833732e-05 -9.292043e-05 -9.775747e-05 -1.028639e-04
## ASV7192     -8.786240e-04 -9.193226e-04 -9.618527e-04 -1.006292e-03
## ASV0873      1.884542e-04  1.881706e-04  1.870273e-04  1.849089e-04
## ASV4749      1.951806e-05  1.897068e-05  1.825901e-05  1.736260e-05
## ASV2174      6.331926e-04  6.618586e-04  6.917503e-04  7.229131e-04
## ASV1476     -6.043654e-04 -6.330115e-04 -6.630099e-04 -6.944240e-04
## ASV0740     -1.716934e-03 -1.798330e-03 -1.883566e-03 -1.972822e-03
## ASV0170     -3.419503e-04 -3.579775e-04 -3.747435e-04 -3.922815e-04
## ASV2466     -1.559354e-03 -1.632409e-03 -1.708831e-03 -1.788770e-03
## ASV1709      5.877123e-04  6.147244e-04  6.429342e-04  6.723909e-04
## ASV6170     -2.415039e-03 -2.529022e-03 -2.648337e-03 -2.773226e-03
## ASV3673      1.178289e-03  1.234139e-03  1.292624e-03  1.353867e-03
## ASV1745     -2.978610e-04 -3.122063e-04 -3.272495e-04 -3.430253e-04
##                                                                    
## (Intercept)  9.970352e-03  1.043662e-02  1.092427e-02  1.143425e-02
## ASV1236      2.009509e-03  2.101836e-03  2.198246e-03  2.298906e-03
## ASV0421      2.033679e-04  2.137484e-04  2.246874e-04  2.362172e-04
## ASV0691     -1.616207e-03 -1.688369e-03 -1.763524e-03 -1.841772e-03
## ASV0899      1.735949e-03  1.815966e-03  1.899542e-03  1.986825e-03
## ASV1004      4.015278e-03  4.200127e-03  4.393183e-03  4.594781e-03
## ASV1041     -1.654716e-03 -1.730786e-03 -1.810219e-03 -1.893153e-03
## ASV1058      2.508636e-03  2.624014e-03  2.744503e-03  2.870314e-03
## ASV12542     9.831337e-04  1.027930e-03  1.074671e-03  1.123434e-03
## ASV1294      2.332919e-03  2.440286e-03  2.552417e-03  2.669507e-03
## ASV13113     7.472172e-04  7.828964e-04  8.202833e-04  8.594599e-04
## ASV1318      2.327149e-03  2.434221e-03  2.546042e-03  2.662804e-03
## ASV2269     -4.035304e-03 -4.220756e-03 -4.414410e-03 -4.616599e-03
## ASV2542      1.914404e-03  2.004462e-03  2.098703e-03  2.197319e-03
## ASV2660     -1.610220e-03 -1.684039e-03 -1.761106e-03 -1.841551e-03
## ASV2737      5.684405e-04  5.940488e-04  6.207415e-04  6.485580e-04
## ASV2840      2.170002e-03  2.268564e-03  2.371374e-03  2.478591e-03
## ASV3053      1.105043e-02  1.155449e-02  1.208049e-02  1.262928e-02
## ASV3077      7.035662e-04  7.357051e-04  7.692475e-04  8.042488e-04
## ASV3134      1.202116e-03  1.259131e-03  1.318840e-03  1.381368e-03
## ASV3140      1.659307e-03  1.736796e-03  1.817830e-03  1.902565e-03
## ASV3579      5.647460e-04  5.920711e-04  6.207370e-04  6.508111e-04
## ASV6119     -1.104347e-03 -1.155095e-03 -1.208086e-03 -1.263413e-03
## ASV7557     -2.244088e-03 -2.347200e-03 -2.454870e-03 -2.567283e-03
## ASV8422      5.635379e-04  5.892565e-04  6.160959e-04  6.441003e-04
## ASV1086     -9.159723e-05 -9.562618e-05 -9.981649e-05 -1.041731e-04
## ASV1310      1.074297e-03  1.123703e-03  1.175297e-03  1.229168e-03
## ASV15750    -1.501735e-04 -1.569197e-04 -1.639492e-04 -1.712721e-04
## ASV16905    -4.614605e-04 -4.826638e-04 -5.048044e-04 -5.279203e-04
## ASV2033      1.912072e-03  2.002458e-03  2.097084e-03  2.196143e-03
## ASV2089      9.725912e-04  1.017300e-03  1.063987e-03  1.112733e-03
## ASV2127      3.157640e-03  3.302835e-03  3.454461e-03  3.612779e-03
## ASV2725      2.543487e-03  2.659719e-03  2.781030e-03  2.907620e-03
## ASV2804     -9.552467e-04 -9.991362e-04 -1.044966e-03 -1.092814e-03
## ASV3075      2.067553e-03  2.163659e-03  2.264123e-03  2.369133e-03
## ASV3327      2.827133e-03  2.959994e-03  3.099013e-03  3.244467e-03
## ASV3342      2.437306e-03  2.551510e-03  2.670977e-03  2.795942e-03
## ASV3532     -2.703318e-03 -2.829364e-03 -2.961161e-03 -3.098959e-03
## ASV3600      1.253919e-03  1.312500e-03  1.373765e-03  1.437831e-03
## ASV4013      2.361061e-03  2.470413e-03  2.584682e-03  2.704076e-03
## ASV4136      2.551333e-03  2.668001e-03  2.789777e-03  2.916862e-03
## ASV4195      9.750573e-03  1.019852e-02  1.066626e-02  1.115460e-02
## ASV4407     -3.767120e-03 -3.940165e-03 -4.120857e-03 -4.309504e-03
## ASV4717      6.721066e-04  7.022527e-04  7.336623e-04  7.663800e-04
## ASV6794      1.579060e-03  1.650786e-03  1.725606e-03  1.803639e-03
## ASV8324     -1.932991e-03 -2.021786e-03 -2.114504e-03 -2.211303e-03
## ASV8981     -5.829098e-05 -6.051485e-05 -6.279313e-05 -6.512372e-05
## ASV9859      6.301983e-04  6.609011e-04  6.931308e-04  7.269661e-04
## ASV0936      1.836168e-03  1.922284e-03  2.012374e-03  2.106615e-03
## ASV12683     1.491981e-06  1.397166e-06  1.282867e-06  1.146879e-06
## ASV1293      1.255099e-03  1.312698e-03  1.372837e-03  1.435618e-03
## ASV13055    -3.719349e-05 -3.856971e-05 -3.997462e-05 -4.140626e-05
## ASV17063    -1.002787e-03 -1.048834e-03 -1.096915e-03 -1.147110e-03
## ASV2228      8.177496e-04  8.552967e-04  8.945012e-04  9.354300e-04
## ASV2769      1.170196e-04  1.229161e-04  1.291227e-04  1.356568e-04
## ASV2803      8.974243e-04  9.380678e-04  9.804522e-04  1.024643e-03
## ASV2896      6.904925e-04  7.229571e-04  7.569292e-04  7.924773e-04
## ASV3062      8.161604e-04  8.553408e-04  8.964151e-04  9.394760e-04
## ASV3107      1.291368e-03  1.351894e-03  1.415211e-03  1.481444e-03
## ASV3265      1.797474e-03  1.879890e-03  1.965932e-03  2.055747e-03
## ASV3666      1.852848e-05  1.933240e-05  2.016690e-05  2.103266e-05
## ASV4497      6.142377e-04  6.425478e-04  6.721180e-04  7.030001e-04
## ASV6914     -8.506203e-05 -8.928855e-05 -9.373269e-05 -9.840630e-05
## ASV0576     -2.179682e-03 -2.278051e-03 -2.380601e-03 -2.487485e-03
## ASV0673      2.357779e-03  2.466814e-03  2.580737e-03  2.699752e-03
## ASV0772      1.090929e-03  1.141530e-03  1.194415e-03  1.249680e-03
## ASV0862      7.657750e-05  8.144118e-05  8.664875e-05  9.222661e-05
## ASV0898      8.286770e-04  8.679827e-04  9.091440e-04  9.522473e-04
## ASV0910      9.655137e-04  1.010882e-03  1.058353e-03  1.108022e-03
## ASV0964     -8.195031e-04 -8.567023e-04 -8.955024e-04 -9.359641e-04
## ASV10059     6.771867e-04  7.094635e-04  7.432793e-04  7.787076e-04
## ASV10263    -1.526982e-03 -1.597139e-03 -1.670396e-03 -1.746880e-03
## ASV1088      1.729137e-03  1.810018e-03  1.894614e-03  1.983092e-03
## ASV1101      2.185712e-03  2.286013e-03  2.390735e-03  2.500057e-03
## ASV1183      5.687526e-04  5.952698e-04  6.229964e-04  6.519852e-04
## ASV11956     5.698199e-04  5.954892e-04  6.222450e-04  6.501269e-04
## ASV12774     4.091839e-05  4.240776e-05  4.392522e-05  4.546824e-05
## ASV1321      2.484132e-03  2.601263e-03  2.723861e-03  2.852176e-03
## ASV13793    -1.052843e-03 -1.101214e-03 -1.151722e-03 -1.204455e-03
## ASV14482     7.044392e-05  7.351856e-05  7.671439e-05  8.003504e-05
## ASV15483     4.238200e-04  4.437177e-04  4.645358e-04  4.863155e-04
## ASV2062      2.004617e-03  2.097346e-03  2.194235e-03  2.295459e-03
## ASV2132      1.614889e-03  1.690603e-03  1.769809e-03  1.852663e-03
## ASV2413      1.558941e-03  1.630637e-03  1.705510e-03  1.783690e-03
## ASV2490      4.844794e-03  5.065517e-03  5.295821e-03  5.536079e-03
## ASV2594      5.915585e-04  6.191386e-04  6.479780e-04  6.781315e-04
## ASV2822     -2.778223e-03 -2.905888e-03 -3.039197e-03 -3.178381e-03
## ASV2863      2.969179e-03  3.104981e-03  3.246730e-03  3.394662e-03
## ASV2910      1.082802e-03  1.132504e-03  1.184399e-03  1.238575e-03
## ASV2980      1.197191e-03  1.252649e-03  1.310603e-03  1.371157e-03
## ASV3307      2.210579e-03  2.312140e-03  2.418190e-03  2.528910e-03
## ASV3474      1.416089e-03  1.483159e-03  1.553386e-03  1.626919e-03
## ASV3502      1.513471e-03  1.583935e-03  1.657603e-03  1.734614e-03
## ASV4236      2.283134e-03  2.386929e-03  2.495206e-03  2.608137e-03
## ASV4842     -2.349619e-04 -2.461329e-04 -2.578318e-04 -2.700828e-04
## ASV4894     -1.052980e-03 -1.101364e-03 -1.151887e-03 -1.204636e-03
## ASV5290      8.207009e-04  8.591251e-04  8.993165e-04  9.413535e-04
## ASV5501      5.049147e-04  5.283961e-04  5.529439e-04  5.786043e-04
## ASV5795      5.507600e-04  5.765782e-04  6.035871e-04  6.318396e-04
## ASV5987     -2.941072e-03 -3.076223e-03 -3.217352e-03 -3.364700e-03
## ASV6267     -3.313898e-03 -3.466167e-03 -3.625169e-03 -3.791177e-03
## ASV6862      1.341319e-03  1.402441e-03  1.466219e-03  1.532755e-03
## ASV7145      5.969477e-04  6.239222e-04  6.520483e-04  6.813690e-04
## ASV7673     -1.052942e-03 -1.101322e-03 -1.151842e-03 -1.204587e-03
## ASV7789      4.930909e-04  5.170241e-04  5.421388e-04  5.684951e-04
## ASV7809      2.437454e-05  2.599252e-05  2.772963e-05  2.959529e-05
## ASV8002     -1.329819e-03 -1.390920e-03 -1.454722e-03 -1.521335e-03
## ASV8205      5.473420e-04  5.729135e-04  5.996563e-04  6.276221e-04
## ASV9155     -3.412032e-04 -3.567436e-04 -3.729579e-04 -3.898720e-04
## ASV9221      1.169760e-04  1.232148e-04  1.298127e-04  1.367925e-04
## ASV9311     -2.133256e-03 -2.231267e-03 -2.333610e-03 -2.440461e-03
## ASV9557     -1.457876e-03 -1.524851e-03 -1.594785e-03 -1.667799e-03
## ASV9936     -2.939917e-03 -3.074963e-03 -3.215975e-03 -3.363196e-03
## ASV1445      1.753936e-03  1.835930e-03  1.921684e-03  2.011364e-03
## ASV4232      6.503957e-04  6.813738e-04  7.138281e-04  7.478290e-04
## ASV6479      2.125647e-04  2.235650e-04  2.351701e-04  2.474161e-04
## ASV0142     -1.271432e-03 -1.329657e-03 -1.390437e-03 -1.453876e-03
## ASV0378      5.536727e-04  5.800704e-04  6.077274e-04  6.367040e-04
## ASV1122      1.692369e-03  1.771716e-03  1.854723e-03  1.941554e-03
## ASV0123     -1.123716e-03 -1.175136e-03 -1.228808e-03 -1.284824e-03
## ASV2064      5.855912e-04  6.119349e-04  6.393890e-04  6.679932e-04
## ASV4459     -8.529222e-05 -8.898191e-05 -9.281334e-05 -9.679027e-05
## ASV0448      4.424063e-04  4.635157e-04  4.856337e-04  5.088083e-04
## ASV0397      1.004961e-03  1.051638e-03  1.100428e-03  1.151419e-03
## ASV0485      1.175029e-03  1.229293e-03  1.285983e-03  1.345200e-03
## ASV1566      1.722610e-03  1.802535e-03  1.886069e-03  1.973364e-03
## ASV1365      1.462973e-03  1.531211e-03  1.602562e-03  1.677163e-03
## ASV1065      2.081736e-03  2.178708e-03  2.280095e-03  2.386088e-03
## ASV0722     -1.068198e-04 -1.118720e-04 -1.171617e-04 -1.227000e-04
## ASV12660    -1.220530e-03 -1.276249e-03 -1.334400e-03 -1.395077e-03
## ASV0223      3.240415e-04  3.390273e-04  3.546854e-04  3.710440e-04
## ASV0229      4.869527e-04  5.097981e-04  5.336994e-04  5.587037e-04
## ASV0877      2.146047e-04  2.242415e-04  2.342814e-04  2.447386e-04
## ASV0983      1.169145e-03  1.223023e-03  1.279299e-03  1.338071e-03
## ASV0626      1.051769e-04  1.109269e-04  1.170185e-04  1.234739e-04
## ASV4146      5.748595e-05  6.015177e-05  6.293639e-05  6.584453e-05
## ASV4175     -1.416213e-03 -1.482536e-03 -1.551911e-03 -1.624475e-03
## ASV2082     -5.995791e-04 -6.292742e-04 -6.604904e-04 -6.933097e-04
## ASV2272      6.762315e-04  7.078109e-04  7.408361e-04  7.753706e-04
## ASV2245     -1.008701e-03 -1.056061e-03 -1.105611e-03 -1.157450e-03
## ASV0590     -5.540489e-04 -5.820225e-04 -6.114754e-04 -6.424913e-04
## ASV0217      2.486548e-05  2.723786e-05  2.983289e-05  3.267094e-05
## ASV0416      8.065962e-04  8.427035e-04  8.803161e-04  9.194863e-04
## ASV1056      9.685081e-04  1.014280e-03  1.062198e-03  1.112361e-03
## ASV7777     -1.382396e-03 -1.446951e-03 -1.514461e-03 -1.585055e-03
## ASV0455      2.489888e-04  2.605804e-04  2.726989e-04  2.853672e-04
## ASV0604      6.336580e-04  6.637781e-04  6.953260e-04  7.283692e-04
## ASV6100     -9.467760e-04 -9.912354e-04 -1.037753e-03 -1.086422e-03
## ASV11359    -2.046960e-03 -2.142598e-03 -2.242617e-03 -2.347209e-03
## ASV6604      2.793569e-04  2.926045e-04  3.064773e-04  3.210045e-04
## ASV5004     -7.309336e-04 -7.649552e-04 -8.005235e-04 -8.377053e-04
## ASV1483     -3.158214e-04 -3.304819e-04 -3.458050e-04 -3.618188e-04
## ASV9773     -9.198158e-04 -9.628822e-04 -1.007930e-03 -1.055048e-03
## ASV4059     -1.909079e-05 -1.906833e-05 -1.895850e-05 -1.874938e-05
## ASV1193      1.120377e-03  1.172449e-03  1.226881e-03  1.283774e-03
## ASV4610     -2.060688e-04 -2.143359e-04 -2.228561e-04 -2.316290e-04
## ASV0742     -1.305124e-04 -1.355216e-04 -1.406582e-04 -1.459183e-04
## ASV1502     -3.522056e-05 -3.752129e-05 -3.998926e-05 -4.263759e-05
## ASV0195      3.647209e-05  3.775354e-05  3.905441e-05  4.037195e-05
## ASV1213      8.129892e-04  8.497430e-04  8.880650e-04  9.280132e-04
## ASV1648     -8.511821e-04 -8.911124e-04 -9.328879e-04 -9.765915e-04
## ASV6984     -7.960213e-04 -8.333777e-04 -8.724618e-04 -9.133514e-04
## ASV0396     -5.597728e-05 -5.811665e-05 -6.030979e-05 -6.255504e-05
## ASV4297      1.169293e-03  1.222585e-03  1.278191e-03  1.336202e-03
## ASV2622      1.796666e-03  1.879278e-03  1.965548e-03  2.055626e-03
## ASV3512      6.601306e-04  6.921756e-04  7.258034e-04  7.610945e-04
## ASV2411      1.187575e-03  1.243765e-03  1.302596e-03  1.364190e-03
## ASV2291     -4.737811e-04 -4.979519e-04 -5.234220e-04 -5.502665e-04
## ASV0807      1.649628e-03  1.726322e-03  1.806494e-03  1.890292e-03
## ASV1292      4.147096e-04  4.332647e-04  4.525929e-04  4.727211e-04
## ASV1035      1.537609e-03  1.607976e-03  1.681430e-03  1.758094e-03
## ASV0070      3.262348e-06  3.843293e-06  4.491659e-06  5.214277e-06
## ASV0255      1.487229e-04  1.554044e-04  1.623663e-04  1.696186e-04
## ASV0057     -4.282568e-04 -4.476380e-04 -4.678476e-04 -4.889166e-04
## ASV0077     -9.455946e-05 -9.867929e-05 -1.029596e-04 -1.074048e-04
## ASV0625      8.884150e-04  9.289526e-04  9.712557e-04  1.015393e-03
## ASV2464      6.060635e-03  6.336373e-03  6.624055e-03  6.924143e-03
## ASV1315      1.543438e-03  1.616641e-03  1.693300e-03  1.773577e-03
## ASV2673      1.322956e-03  1.385745e-03  1.451502e-03  1.520367e-03
## ASV2161      5.604882e-04  5.870390e-04  6.148410e-04  6.439523e-04
## ASV0337     -3.243773e-04 -3.395886e-04 -3.555018e-04 -3.721483e-04
## ASV7680     -2.114034e-03 -2.213294e-03 -2.317147e-03 -2.425800e-03
## ASV0611      1.179908e-03  1.235340e-03  1.293341e-03  1.354026e-03
## ASV3118     -1.209360e-03 -1.266904e-03 -1.327183e-03 -1.390326e-03
## ASV1284      5.048604e-04  5.254955e-04  5.467965e-04  5.687665e-04
## ASV0889      9.097850e-04  9.517239e-04  9.955311e-04  1.041284e-03
## ASV4649     -4.505336e-04 -4.715454e-04 -4.935162e-04 -5.164879e-04
## ASV1108     -8.989422e-04 -9.419815e-04 -9.870914e-04 -1.034372e-03
## ASV0738      4.826217e-04  5.063882e-04  5.313592e-04  5.575985e-04
## ASV0473     -9.203868e-05 -9.687379e-05 -1.019798e-04 -1.073730e-04
## ASV0598     -2.415796e-04 -2.537136e-04 -2.664844e-04 -2.799277e-04
## ASV0429      6.797665e-04  7.109069e-04  7.434145e-04  7.773437e-04
## ASV1549      1.219796e-03  1.277729e-03  1.338405e-03  1.401953e-03
## ASV1203      9.872945e-04  1.032914e-03  1.080575e-03  1.130363e-03
## ASV4532      4.684440e-05  4.879947e-05  5.082274e-05  5.291533e-05
## ASV0274      1.638356e-04  1.717907e-04  1.801383e-04  1.888980e-04
## ASV0163     -7.733770e-04 -8.085923e-04 -8.453346e-04 -8.836632e-04
## ASV1298      8.883191e-05  9.267171e-05  9.665923e-05  1.007985e-04
## ASV9424     -1.635302e-03 -1.712242e-03 -1.792759e-03 -1.877014e-03
## ASV0412      1.718052e-03  1.797181e-03  1.879828e-03  1.966138e-03
## ASV0284      3.732169e-04  3.897458e-04  4.069464e-04  4.248403e-04
## ASV0620     -3.298574e-04 -3.461185e-04 -3.632048e-04 -3.811601e-04
## ASV0153     -1.630937e-03 -1.708396e-03 -1.789523e-03 -1.874488e-03
## ASV0498      5.813176e-04  6.086472e-04  6.372439e-04  6.671648e-04
## ASV0097      3.205154e-04  3.357297e-04  3.516638e-04  3.683514e-04
## ASV0104     -2.316743e-03 -2.424226e-03 -2.536559e-03 -2.653950e-03
## ASV1282      8.103222e-04  8.473763e-04  8.860507e-04  9.264089e-04
## ASV3883     -6.107417e-04 -6.402776e-04 -6.712605e-04 -7.037629e-04
## ASV0801      3.102991e-04  3.248734e-04  3.401223e-04  3.560759e-04
## ASV1611     -1.459670e-03 -1.528664e-03 -1.600893e-03 -1.676508e-03
## ASV0227     -2.483588e-04 -2.608508e-04 -2.739986e-04 -2.878387e-04
## ASV0833      5.004315e-04  5.238894e-04  5.484287e-04  5.740974e-04
## ASV0718      2.243880e-03  2.348788e-03  2.458509e-03  2.573255e-03
## ASV1139      3.130370e-04  3.265213e-04  3.405149e-04  3.550301e-04
## ASV0766     -3.031378e-04 -3.178291e-04 -3.332427e-04 -3.494148e-04
## ASV2091      1.864693e-03  1.949832e-03  2.038683e-03  2.131392e-03
## ASV1238     -1.657333e-03 -1.735353e-03 -1.817006e-03 -1.902455e-03
## ASV9193     -1.401990e-04 -1.477213e-04 -1.556808e-04 -1.641057e-04
## ASV0290      2.525210e-04  2.635998e-04  2.751190e-04  2.870918e-04
## ASV0231      6.763011e-04  7.074533e-04  7.399905e-04  7.739695e-04
## ASV0185      3.711150e-04  3.893487e-04  4.085028e-04  4.286257e-04
## ASV2330      7.866789e-04  8.223519e-04  8.595568e-04  8.983514e-04
## ASV3119     -3.370956e-04 -3.536062e-04 -3.709453e-04 -3.891561e-04
## ASV2368     -8.431722e-04 -8.832354e-04 -9.251986e-04 -9.691514e-04
## ASV0122     -4.186498e-04 -4.380159e-04 -4.582507e-04 -4.793909e-04
## ASV1044      1.051502e-03  1.101212e-03  1.153254e-03  1.207736e-03
## ASV0160     -4.575749e-04 -4.783408e-04 -5.000004e-04 -5.225873e-04
## ASV0326      1.171784e-04  1.226809e-04  1.284379e-04  1.344606e-04
## ASV1388      2.167945e-03  2.268431e-03  2.373444e-03  2.483173e-03
## ASV0792      1.624075e-03  1.698589e-03  1.776388e-03  1.857603e-03
## ASV0036     -4.890171e-04 -5.122559e-04 -5.365959e-04 -5.620888e-04
## ASV2125      1.545677e-03  1.617520e-03  1.692618e-03  1.771110e-03
## ASV1075     -2.333473e-05 -2.441232e-05 -2.553844e-05 -2.671520e-05
## ASV0390      8.080762e-04  8.464393e-04  8.866182e-04  9.286981e-04
## ASV3790     -1.160468e-03 -1.214923e-03 -1.271895e-03 -1.331497e-03
## ASV1535     -3.224985e-04 -3.382305e-04 -3.547463e-04 -3.720862e-04
## ASV0263      1.429292e-03  1.495969e-03  1.565691e-03  1.638591e-03
## ASV0675      2.127444e-03  2.227681e-03  2.332590e-03  2.442384e-03
## ASV3348      1.685503e-04  1.766847e-04  1.852163e-04  1.941645e-04
## ASV0058     -6.420426e-04 -6.717606e-04 -7.028133e-04 -7.352567e-04
## ASV4142      9.089702e-04  9.506500e-04  9.941630e-04  1.039582e-03
## ASV0059     -5.186855e-04 -5.426218e-04 -5.676261e-04 -5.937428e-04
## ASV0013     -9.131971e-04 -9.557651e-04 -1.000274e-03 -1.046807e-03
## ASV0033     -4.257637e-04 -4.459622e-04 -4.671146e-04 -4.892656e-04
## ASV4354     -5.378111e-04 -5.628749e-04 -5.890819e-04 -6.164822e-04
## ASV0022     -3.597232e-04 -3.767789e-04 -3.946394e-04 -4.133421e-04
## ASV0134     -3.371541e-04 -3.533849e-04 -3.704045e-04 -3.882516e-04
## ASV0415      5.073455e-05  5.335522e-05  5.611893e-05  5.903403e-05
## ASV10103    -2.009724e-03 -2.104437e-03 -2.203566e-03 -2.307313e-03
## ASV1613      1.538813e-03  1.609465e-03  1.683236e-03  1.760250e-03
## ASV0135     -2.006869e-04 -2.097650e-04 -2.192307e-04 -2.290982e-04
## ASV0469     -1.975442e-03 -2.066630e-03 -2.161891e-03 -2.261395e-03
## ASV0471      1.192377e-03  1.247893e-03  1.305934e-03  1.366608e-03
## ASV0451     -1.780486e-04 -1.871436e-04 -1.967285e-04 -2.068317e-04
## ASV0747      6.746374e-04  7.062344e-04  7.392856e-04  7.738556e-04
## ASV1314     -6.669644e-04 -6.986927e-04 -7.319287e-04 -7.667440e-04
## ASV0425     -2.466440e-03 -2.579326e-03 -2.697162e-03 -2.820144e-03
## ASV0559     -6.016468e-04 -6.295602e-04 -6.587352e-04 -6.892258e-04
## ASV0148     -1.472121e-04 -1.535374e-04 -1.600998e-04 -1.669048e-04
## ASV0129      1.182299e-04  1.247529e-04  1.316699e-04  1.390073e-04
## ASV1072      1.682591e-04  1.757534e-04  1.835559e-04  1.916769e-04
## ASV2390      1.273692e-03  1.331544e-03  1.391888e-03  1.454819e-03
## ASV0548      8.215700e-04  8.597710e-04  8.997043e-04  9.414442e-04
## ASV0168     -4.251189e-04 -4.447286e-04 -4.652127e-04 -4.866074e-04
## ASV0066     -4.771473e-04 -4.992433e-04 -5.223324e-04 -5.464566e-04
## ASV0468     -2.505276e-04 -2.622276e-04 -2.744633e-04 -2.872581e-04
## ASV0172     -1.491626e-04 -1.557852e-04 -1.626782e-04 -1.698503e-04
## ASV0236     -5.484101e-05 -5.608251e-05 -5.725572e-05 -5.834585e-05
## ASV0250      6.436048e-04  6.747552e-04  7.074356e-04  7.417230e-04
## ASV0338      3.109289e-04  3.257213e-04  3.412153e-04  3.574438e-04
## ASV0450     -5.302746e-05 -5.579385e-05 -5.871419e-05 -6.179781e-05
## ASV0377      5.969566e-04  6.245569e-04  6.533939e-04  6.835196e-04
## ASV1022     -2.625446e-05 -2.743298e-05 -2.866044e-05 -2.993844e-05
## ASV6174     -1.010489e-05 -1.070275e-05 -1.134058e-05 -1.202143e-05
## ASV0786     -7.044337e-05 -7.429841e-05 -7.838247e-05 -8.271040e-05
## ASV0053     -6.391678e-04 -6.690288e-04 -7.002572e-04 -7.329132e-04
## ASV0697     -3.958178e-04 -4.139741e-04 -4.329307e-04 -4.527198e-04
## ASV0785      8.266288e-04  8.648620e-04  9.048096e-04  9.465435e-04
## ASV1967     -8.246902e-04 -8.626637e-04 -9.023254e-04 -9.437450e-04
## ASV0385      2.677021e-04  2.804939e-04  2.938981e-04  3.079440e-04
## ASV0295      3.988188e-05  4.214410e-05  4.454793e-05  4.710319e-05
## ASV0072     -6.460731e-04 -6.757850e-04 -7.068126e-04 -7.392094e-04
## ASV0157     -9.424959e-05 -9.804181e-05 -1.019494e-04 -1.059719e-04
## ASV0501      1.378028e-03  1.442503e-03  1.509939e-03  1.580469e-03
## ASV10729    -1.726745e-03 -1.807775e-03 -1.892550e-03 -1.981238e-03
## ASV1470      9.121159e-04  9.534197e-04  9.964914e-04  1.041397e-03
## ASV0050     -1.510075e-03 -1.580012e-03 -1.653094e-03 -1.729453e-03
## ASV0411     -3.334215e-04 -3.492064e-04 -3.657339e-04 -3.830384e-04
## ASV0549      5.386936e-04  5.640666e-04  5.906211e-04  6.184109e-04
## ASV0184      1.831665e-04  1.916436e-04  2.005018e-04  2.097573e-04
## ASV0705      3.648072e-04  3.815836e-04  3.991027e-04  4.173948e-04
## ASV1715      7.601744e-04  7.956613e-04  8.327708e-04  8.715738e-04
## ASV0603      1.169709e-04  1.224960e-04  1.282805e-04  1.343364e-04
## ASV0826      1.290643e-03  1.350554e-03  1.413171e-03  1.478612e-03
## ASV0034     -4.168292e-04 -4.360203e-04 -4.560634e-04 -4.769935e-04
## ASV0838      3.140565e-04  3.273070e-04  3.410281e-04  3.552273e-04
## ASV0614     -3.537051e-04 -3.701066e-04 -3.872477e-04 -4.051602e-04
## ASV0014     -9.349202e-04 -9.783937e-04 -1.023839e-03 -1.071340e-03
## ASV0585      1.269534e-04  1.317738e-04  1.367101e-04  1.417574e-04
## ASV0016     -9.766743e-04 -1.022089e-03 -1.069562e-03 -1.119184e-03
## ASV5394     -7.275757e-04 -7.616224e-04 -7.972336e-04 -8.344784e-04
## ASV0666      1.620177e-03  1.694455e-03  1.772001e-03  1.852947e-03
## ASV2085      4.070736e-04  4.241889e-04  4.419090e-04  4.602435e-04
## ASV0003     -6.662883e-04 -6.972558e-04 -7.296262e-04 -7.634598e-04
## ASV0346      3.268181e-04  3.423860e-04  3.586949e-04  3.757797e-04
## ASV0267     -1.056510e-05 -1.070184e-05 -1.081076e-05 -1.088739e-05
## ASV0353      5.236540e-04  5.483974e-04  5.743006e-04  6.014169e-04
## ASV2419      1.439994e-03  1.506657e-03  1.576315e-03  1.649095e-03
## ASV0447      7.663908e-04  8.026713e-04  8.406582e-04  8.804306e-04
## ASV0654      1.155361e-03  1.209135e-03  1.265352e-03  1.324117e-03
## ASV0151      1.448108e-04  1.519732e-04  1.595017e-04  1.674159e-04
## ASV0065     -4.493343e-04 -4.701457e-04 -4.918932e-04 -5.146162e-04
## ASV0527      1.102010e-03  1.153179e-03  1.206661e-03  1.262555e-03
## ASV4055     -1.672764e-04 -1.753530e-04 -1.838252e-04 -1.927127e-04
## ASV0166     -5.608435e-04 -5.865564e-04 -6.134008e-04 -6.414220e-04
## ASV0417     -2.341507e-04 -2.446761e-04 -2.556446e-04 -2.670718e-04
## ASV0078     -3.310609e-04 -3.462988e-04 -3.622128e-04 -3.788303e-04
## ASV0322     -6.710281e-05 -6.991170e-05 -7.281698e-05 -7.581962e-05
## ASV0156     -7.721338e-04 -8.083577e-04 -8.462554e-04 -8.859019e-04
## ASV0648     -1.672185e-03 -1.750847e-03 -1.833162e-03 -1.919297e-03
## ASV0407     -1.237274e-04 -1.296218e-04 -1.357971e-04 -1.422667e-04
## ASV2030     -2.850284e-04 -2.981166e-04 -3.117853e-04 -3.260587e-04
## ASV0300      1.971577e-04  2.065447e-04  2.163782e-04  2.266795e-04
## ASV1150      4.207200e-05  4.418010e-05  4.639808e-05  4.873202e-05
## ASV0958      6.085901e-04  6.375865e-04  6.679649e-04  6.997912e-04
## ASV0216     -6.959622e-04 -7.280768e-04 -7.616256e-04 -7.966685e-04
## ASV0446      1.030199e-03  1.078680e-03  1.129414e-03  1.182503e-03
## ASV0367     -6.790906e-04 -7.108566e-04 -7.440815e-04 -7.788295e-04
## ASV0200     -4.042521e-04 -4.231497e-04 -4.429139e-04 -4.635828e-04
## ASV0334     -2.342558e-04 -2.445166e-04 -2.551835e-04 -2.662685e-04
## ASV1311      2.779600e-04  2.903866e-04  3.033294e-04  3.168060e-04
## ASV0458      4.136307e-04  4.319884e-04  4.510967e-04  4.709802e-04
## ASV1371      6.095937e-05  6.393759e-05  6.706421e-05  7.034684e-05
## ASV0418      9.212050e-04  9.633252e-04  1.007288e-03  1.053168e-03
## ASV0004      1.339187e-04  1.400257e-04  1.463982e-04  1.530467e-04
## ASV1943      2.656043e-03  2.772937e-03  2.894525e-03  3.020955e-03
## ASV1495     -1.587852e-04 -1.671982e-04 -1.760911e-04 -1.854937e-04
## ASV0901     -7.559262e-04 -7.915953e-04 -8.289322e-04 -8.680134e-04
## ASV0628      4.198503e-04  4.388305e-04  4.586197e-04  4.792477e-04
## ASV0400      2.512560e-04  2.627998e-04  2.748536e-04  2.874380e-04
## ASV0116     -2.225481e-04 -2.330382e-04 -2.440176e-04 -2.555087e-04
## ASV0788      1.964574e-03  2.057296e-03  2.154354e-03  2.255948e-03
## ASV0117      1.425186e-04  1.493498e-04  1.565104e-04  1.640162e-04
## ASV3137     -4.725731e-05 -4.942874e-05 -5.169619e-05 -5.406357e-05
## ASV0001      1.441780e-04  1.507357e-04  1.575769e-04  1.647126e-04
## ASV1651      4.089007e-04  4.275836e-04  4.470827e-04  4.674301e-04
## ASV1692      1.637614e-03  1.714841e-03  1.795672e-03  1.880275e-03
## ASV0660      6.132537e-04  6.408420e-04  6.695928e-04  6.995475e-04
## ASV0508      3.119795e-05  3.258063e-05  3.401969e-05  3.551696e-05
## ASV1660     -3.200840e-04 -3.356483e-04 -3.519825e-04 -3.691257e-04
## ASV0233      5.106422e-04  5.344970e-04  5.594444e-04  5.855323e-04
## ASV1343     -9.341409e-04 -9.781214e-04 -1.024149e-03 -1.072316e-03
## ASV0209      4.816937e-04  5.036253e-04  5.265073e-04  5.503765e-04
## ASV0193     -5.603483e-04 -5.859538e-04 -6.126777e-04 -6.405642e-04
## ASV0357      1.986744e-04  2.084849e-04  2.187955e-04  2.296331e-04
## ASV0198      4.207535e-04  4.401933e-04  4.605031e-04  4.817190e-04
## ASV0007      1.282158e-04  1.340055e-04  1.400415e-04  1.463329e-04
## ASV1772     -1.925651e-04 -2.011926e-04 -2.101791e-04 -2.195366e-04
## ASV0009      1.067706e-04  1.115545e-04  1.165383e-04  1.217289e-04
## ASV0006     -1.094388e-04 -1.146692e-04 -1.201504e-04 -1.258943e-04
## ASV0011     -3.860994e-04 -4.042397e-04 -4.232205e-04 -4.430796e-04
## ASV0015      8.071592e-05  8.433209e-05  8.809925e-05  9.202266e-05
## ASV0017      9.088722e-05  9.496055e-05  9.920415e-05  1.036240e-04
## ASV0235     -3.556303e-04 -3.723931e-04 -3.899375e-04 -4.082990e-04
## ASV0382      2.782421e-04  2.913707e-04  3.051120e-04  3.194938e-04
## ASV2357      1.164030e-03  1.218675e-03  1.275848e-03  1.335662e-03
## ASV0567     -2.246042e-04 -2.351839e-04 -2.462570e-04 -2.578460e-04
## ASV0165      1.941901e-04  2.033088e-04  2.128494e-04  2.228309e-04
## ASV0005      2.846043e-04  2.978347e-04  3.116647e-04  3.261200e-04
## ASV0384     -3.756099e-05 -3.900364e-05 -4.048258e-05 -4.199657e-05
## ASV0002      5.407343e-05  5.654788e-05  5.913088e-05  6.182675e-05
## ASV3017      1.532160e-03  1.602233e-03  1.675371e-03  1.751698e-03
## ASV0091     -3.858419e-05 -4.035819e-05 -4.221093e-05 -4.414569e-05
## ASV0186     -5.720971e-04 -5.987650e-04 -6.266484e-04 -6.557999e-04
## ASV0370      3.060866e-04  3.202321e-04  3.350105e-04  3.504483e-04
## ASV0018      3.640575e-04  3.810063e-04  3.987256e-04  4.172486e-04
## ASV1377      3.701229e-03  3.871152e-03  4.048574e-03  4.233800e-03
## ASV0019      3.817614e-04  3.995420e-04  4.181317e-04  4.375654e-04
## ASV0023     -2.355668e-04 -2.466813e-04 -2.583152e-04 -2.704922e-04
## ASV2194      3.766814e-04  3.945416e-04  4.132451e-04  4.328314e-04
## ASV1155      1.551870e-03  1.622909e-03  1.697069e-03  1.774477e-03
## ASV0510     -4.244388e-04 -4.435018e-04 -4.633647e-04 -4.840556e-04
## ASV2371     -9.339774e-04 -9.767665e-04 -1.021438e-03 -1.068067e-03
## ASV0024     -2.937783e-04 -3.076182e-04 -3.221028e-04 -3.372615e-04
## ASV2452      9.508634e-04  9.938813e-04  1.038736e-03  1.085496e-03
## ASV2332     -2.670709e-03 -2.793590e-03 -2.921926e-03 -3.055943e-03
## ASV2591      6.534026e-04  6.856328e-04  7.194944e-04  7.550729e-04
## ASV0521      5.973198e-04  6.254366e-04  6.548613e-04  6.856531e-04
## ASV5542      5.709841e-04  5.979201e-04  6.261124e-04  6.556179e-04
## ASV0336     -6.426380e-05 -6.765577e-05 -7.123961e-05 -7.502712e-05
## ASV10102     1.056692e-03  1.106432e-03  1.158485e-03  1.212955e-03
## ASV16823    -1.694206e-03 -1.770959e-03 -1.851007e-03 -1.934476e-03
## ASV3104      8.765385e-03  9.162449e-03  9.576556e-03  1.000835e-02
## ASV0781      1.192813e-03  1.248287e-03  1.306277e-03  1.366892e-03
## ASV10899     6.602755e-04  6.928351e-04  7.270465e-04  7.629971e-04
## ASV11222    -2.981602e-03 -3.116659e-03 -3.257512e-03 -3.404381e-03
## ASV11327    -2.676707e-03 -2.797942e-03 -2.924378e-03 -3.056214e-03
## ASV12458    -2.981056e-03 -3.116063e-03 -3.256861e-03 -3.403670e-03
## ASV1636      1.657887e-03  1.734226e-03  1.813955e-03  1.897212e-03
## ASV1890     -1.394582e-03 -1.456652e-03 -1.521283e-03 -1.588561e-03
## ASV2898      2.222199e-03  2.324543e-03  2.431434e-03  2.543060e-03
## ASV8328      1.948749e-04  2.069011e-04  2.197509e-04  2.334857e-04
## ASV0709     -2.460531e-03 -2.574642e-03 -2.693896e-03 -2.818512e-03
## ASV0856      1.994986e-03  2.089679e-03  2.188849e-03  2.292704e-03
## ASV0909      5.361395e-04  5.633913e-04  5.920995e-04  6.223478e-04
## ASV0937     -1.427012e-03 -1.494020e-03 -1.564132e-03 -1.637488e-03
## ASV11390    -4.254290e-03 -4.446943e-03 -4.647859e-03 -4.857351e-03
## ASV11966     9.656659e-04  1.012034e-03  1.060641e-03  1.111597e-03
## ASV12990     7.327997e-04  7.664687e-04  8.016240e-04  8.383253e-04
## ASV14797     1.091871e-03  1.141727e-03  1.193758e-03  1.248048e-03
## ASV14904    -6.104655e-03 -6.381094e-03 -6.669390e-03 -6.969990e-03
## ASV15304     5.924973e-04  6.215318e-04  6.520213e-04  6.840410e-04
## ASV16696    -2.109127e-03 -2.204629e-03 -2.304226e-03 -2.408073e-03
## ASV1690      3.383279e-03  3.544245e-03  3.712847e-03  3.889446e-03
## ASV2029      2.424674e-03  2.536827e-03  2.654012e-03  2.776439e-03
## ASV2834      2.996593e-03  3.137060e-03  3.284004e-03  3.437714e-03
## ASV4003      2.401988e-03  2.517247e-03  2.638073e-03  2.764739e-03
## ASV4064      1.416358e-03  1.483012e-03  1.552762e-03  1.625749e-03
## ASV4294      8.213434e-04  8.615069e-04  9.036781e-04  9.479607e-04
## ASV4609      8.213326e-04  8.592908e-04  8.989464e-04  9.403700e-04
## ASV6283     -1.971653e-03 -2.060934e-03 -2.154044e-03 -2.251128e-03
## ASV6491     -2.825733e-03 -2.953677e-03 -3.087107e-03 -3.226230e-03
## ASV7453      1.276685e-03  1.338167e-03  1.402635e-03  1.470236e-03
## ASV7959      4.337690e-04  4.557887e-04  4.789802e-04  5.034099e-04
## ASV8219      2.441922e-02  2.552482e-02  2.667783e-02  2.788003e-02
## ASV8547     -2.529538e-03 -2.644054e-03 -2.763479e-03 -2.887998e-03
## ASV9319      1.048254e-03  1.097926e-03  1.149938e-03  1.204400e-03
## ASV9382     -4.949111e-03 -5.173152e-03 -5.406796e-03 -5.650407e-03
## ASV11516    -3.305308e-03 -3.454922e-03 -3.610947e-03 -3.773626e-03
## ASV14377    -2.386393e-03 -2.494402e-03 -2.607039e-03 -2.724478e-03
## ASV1867      1.772694e-03  1.856073e-03  1.943323e-03  2.034620e-03
## ASV1895      9.290050e-04  9.710956e-04  1.014987e-03  1.060747e-03
## ASV3168      1.157650e-03  1.210569e-03  1.265799e-03  1.323430e-03
## ASV4449      6.262141e-03  6.552834e-03  6.856677e-03  7.174233e-03
## ASV6596      1.247141e-03  1.307407e-03  1.370623e-03  1.436935e-03
## ASV7492     -2.896206e-04 -3.008230e-04 -3.123230e-04 -3.241143e-04
## ASV9854     -5.149018e-04 -5.379976e-04 -5.620648e-04 -5.871386e-04
## ASV6296      4.004055e-02  4.185258e-02  4.374223e-02  4.571242e-02
## ASV4201      1.325935e-04  1.411028e-04  1.502179e-04  1.599852e-04
## ASV0552      1.229406e-03  1.287114e-03  1.347490e-03  1.410654e-03
## ASV3671     -8.348556e-04 -8.733358e-04 -9.135335e-04 -9.555205e-04
## ASV3529     -2.586631e-04 -2.688155e-04 -2.792562e-04 -2.899821e-04
## ASV1060      3.222549e-04  3.375761e-04  3.536249e-04  3.704357e-04
## ASV0239     -4.620893e-04 -4.829297e-04 -5.046544e-04 -5.272958e-04
## ASV5711     -2.046529e-03 -2.140674e-03 -2.238998e-03 -2.341672e-03
## ASV4152     -2.851912e-03 -2.984921e-03 -3.124003e-03 -3.269424e-03
## ASV1461      1.485296e-03  1.552537e-03  1.622655e-03  1.695757e-03
## ASV2877      7.668769e-04  8.017886e-04  8.382120e-04  8.762053e-04
## ASV0012      1.290909e-04  1.351026e-04  1.413878e-04  1.479585e-04
## ASV9823      2.001591e-04  2.087853e-04  2.177371e-04  2.270221e-04
## ASV0008      1.381756e-04  1.445899e-04  1.512942e-04  1.583009e-04
## ASV7832     -1.675261e-03 -1.753519e-03 -1.835365e-03 -1.920958e-03
## ASV1915     -2.187132e-04 -2.286480e-04 -2.390135e-04 -2.498268e-04
## ASV0055     -1.409779e-04 -1.478661e-04 -1.550984e-04 -1.626925e-04
## ASV0032      7.352896e-05  7.674782e-05  8.009385e-05  8.357075e-05
## ASV2977     -2.370700e-03 -2.481077e-03 -2.596475e-03 -2.717114e-03
## ASV0466      1.964579e-03  2.053532e-03  2.146294e-03  2.243007e-03
## ASV3866      1.284361e-03  1.344937e-03  1.408342e-03  1.474705e-03
## ASV0040      4.679601e-04  4.898593e-04  5.127651e-04  5.367221e-04
## ASV0496     -8.684615e-05 -9.194986e-05 -9.738604e-05 -1.031785e-04
## ASV0052      3.925649e-04  4.109506e-04  4.301827e-04  4.502986e-04
## ASV3828     -1.420306e-03 -1.484494e-03 -1.551424e-03 -1.621198e-03
## ASV1930      7.166592e-04  7.495752e-04  7.839439e-04  8.198238e-04
## ASV2126      1.210928e-03  1.266968e-03  1.325523e-03  1.386701e-03
## ASV0793      1.458120e-03  1.526760e-03  1.598594e-03  1.673764e-03
## ASV0299     -2.819363e-05 -2.952809e-05 -3.092643e-05 -3.239191e-05
## ASV0208      1.060005e-03  1.109593e-03  1.161458e-03  1.215701e-03
## ASV0511     -4.544927e-04 -4.749801e-04 -4.963348e-04 -5.185880e-04
## ASV1123     -1.370286e-03 -1.432217e-03 -1.496789e-03 -1.564100e-03
## ASV0099      3.684111e-05  3.867878e-05  4.061207e-05  4.264632e-05
## ASV0752     -7.403365e-04 -7.755870e-04 -8.125139e-04 -8.511967e-04
## ASV0883      1.017910e-03  1.066272e-03  1.116924e-03  1.169974e-03
## ASV0683      1.338044e-03  1.401292e-03  1.467507e-03  1.536824e-03
## ASV4117     -2.157755e-03 -2.258589e-03 -2.364047e-03 -2.474334e-03
## ASV2172      1.510266e-04  1.576262e-04  1.644844e-04  1.716085e-04
## ASV0330     -4.010682e-04 -4.199048e-04 -4.396135e-04 -4.602338e-04
## ASV0728      2.000820e-03  2.093996e-03  2.191409e-03  2.293242e-03
## ASV0499      5.197538e-04  5.443588e-04  5.701215e-04  5.970955e-04
## ASV0120     -8.864269e-04 -9.277473e-04 -9.709507e-04 -1.016119e-03
## ASV1446      7.262040e-04  7.580893e-04  7.912451e-04  8.257098e-04
## ASV17171    -1.717485e-03 -1.797274e-03 -1.880680e-03 -1.967857e-03
## ASV0533      1.223656e-04  1.282857e-04  1.344962e-04  1.410116e-04
## ASV2495     -3.954591e-04 -4.148685e-04 -4.352581e-04 -4.566796e-04
## ASV5582      8.324277e-04  8.695049e-04  9.081097e-04  9.482933e-04
## ASV1488      3.082384e-04  3.223666e-04  3.371155e-04  3.525100e-04
## ASV0682      3.774487e-04  3.953715e-04  4.141424e-04  4.338013e-04
## ASV0068     -6.697266e-04 -7.010110e-04 -7.337274e-04 -7.679386e-04
## ASV1987     -1.629461e-03 -1.707167e-03 -1.788580e-03 -1.873877e-03
## ASV0035     -1.082561e-04 -1.139517e-04 -1.199695e-04 -1.263294e-04
## ASV7192     -1.052720e-03 -1.101221e-03 -1.151880e-03 -1.204788e-03
## ASV0873      1.816885e-04  1.772263e-04  1.713688e-04  1.639479e-04
## ASV4749      1.625891e-05  1.492311e-05  1.332791e-05  1.144329e-05
## ASV2174      7.553936e-04  7.892393e-04  8.244989e-04  8.612216e-04
## ASV1476     -7.273201e-04 -7.617676e-04 -7.978392e-04 -8.356107e-04
## ASV0740     -2.066287e-03 -2.164155e-03 -2.266632e-03 -2.373933e-03
## ASV0170     -4.106255e-04 -4.298114e-04 -4.498762e-04 -4.708587e-04
## ASV2466     -1.872382e-03 -1.959830e-03 -2.051284e-03 -2.146919e-03
## ASV1709      7.031455e-04  7.352509e-04  7.687614e-04  8.037336e-04
## ASV6170     -2.903947e-03 -3.040766e-03 -3.183960e-03 -3.333821e-03
## ASV3673      1.417996e-03  1.485146e-03  1.555457e-03  1.629077e-03
## ASV1745     -3.595700e-04 -3.769218e-04 -3.951207e-04 -4.142090e-04
##                                                                    
## (Intercept)  1.196753e-02  1.252513e-02  1.310810e-02  1.371755e-02
## ASV1236      2.403986e-03  2.513664e-03  2.628122e-03  2.747547e-03
## ASV0421      2.483719e-04  2.611882e-04  2.747046e-04  2.889624e-04
## ASV0691     -1.923220e-03 -2.007971e-03 -2.096133e-03 -2.187813e-03
## ASV0899      2.077965e-03  2.173119e-03  2.272447e-03  2.376116e-03
## ASV1004      4.805268e-03  5.025004e-03  5.254357e-03  5.493709e-03
## ASV1041     -1.979728e-03 -2.070088e-03 -2.164383e-03 -2.262765e-03
## ASV1058      3.001662e-03  3.138768e-03  3.281862e-03  3.431180e-03
## ASV12542     1.174294e-03  1.227333e-03  1.282632e-03  1.340274e-03
## ASV1294      2.791758e-03  2.919377e-03  3.052580e-03  3.191586e-03
## ASV13113     9.005123e-04  9.435306e-04  9.886093e-04  1.035848e-03
## ASV1318      2.784709e-03  2.911962e-03  3.044778e-03  3.183376e-03
## ASV2269     -4.827665e-03 -5.047963e-03 -5.277859e-03 -5.517727e-03
## ASV2542      2.300505e-03  2.408469e-03  2.521426e-03  2.639598e-03
## ASV2660     -1.925508e-03 -2.013115e-03 -2.104516e-03 -2.199855e-03
## ASV2737      6.775387e-04  7.077247e-04  7.391580e-04  7.718813e-04
## ASV2840      2.590382e-03  2.706917e-03  2.828367e-03  2.954911e-03
## ASV3053      1.320175e-02  1.379881e-02  1.442138e-02  1.507042e-02
## ASV3077      8.407660e-04  8.788578e-04  9.185845e-04  9.600079e-04
## ASV3134      1.446848e-03  1.515416e-03  1.587218e-03  1.662405e-03
## ASV3140      1.991163e-03  2.083790e-03  2.180622e-03  2.281840e-03
## ASV3579      6.823641e-04  7.154706e-04  7.502090e-04  7.866617e-04
## ASV6119     -1.321168e-03 -1.381449e-03 -1.444355e-03 -1.509990e-03
## ASV7557     -2.684630e-03 -2.807108e-03 -2.934918e-03 -3.068270e-03
## ASV8422      6.733148e-04  7.037860e-04  7.355617e-04  7.686911e-04
## ASV1086     -1.087012e-04 -1.134056e-04 -1.182914e-04 -1.233635e-04
## ASV1310      1.285409e-03  1.344113e-03  1.405380e-03  1.469309e-03
## ASV15750    -1.788984e-04 -1.868387e-04 -1.951033e-04 -2.037027e-04
## ASV16905    -5.520507e-04 -5.772361e-04 -6.035181e-04 -6.309397e-04
## ASV2033      2.299842e-03  2.408392e-03  2.522017e-03  2.640947e-03
## ASV2089      1.163621e-03  1.216735e-03  1.272166e-03  1.330002e-03
## ASV2127      3.778059e-03  3.950581e-03  4.130632e-03  4.318508e-03
## ASV2725      3.039695e-03  3.177467e-03  3.321154e-03  3.470980e-03
## ASV2804     -1.142762e-03 -1.194893e-03 -1.249294e-03 -1.306053e-03
## ASV3075      2.478885e-03  2.593581e-03  2.713432e-03  2.838656e-03
## ASV3327      3.396647e-03  3.555853e-03  3.722400e-03  3.896614e-03
## ASV3342      2.926647e-03  3.063348e-03  3.206308e-03  3.355803e-03
## ASV3532     -3.243019e-03 -3.393613e-03 -3.551020e-03 -3.715534e-03
## ASV3600      1.504822e-03  1.574864e-03  1.648092e-03  1.724641e-03
## ASV4013      2.828810e-03  2.959106e-03  3.095195e-03  3.237316e-03
## ASV4136      3.049466e-03  3.187804e-03  3.332096e-03  3.482571e-03
## ASV4195      1.166436e-02  1.219640e-02  1.275159e-02  1.333085e-02
## ASV4407     -4.506425e-03 -4.711950e-03 -4.926419e-03 -5.150179e-03
## ASV4717      8.004513e-04  8.359225e-04  8.728406e-04  9.112530e-04
## ASV6794      1.885006e-03  1.969833e-03  2.058247e-03  2.150380e-03
## ASV8324     -2.312349e-03 -2.417810e-03 -2.527860e-03 -2.642678e-03
## ASV8981     -6.750403e-05 -6.993088e-05 -7.240046e-05 -7.490828e-05
## ASV9859      7.624899e-04  7.997896e-04  8.389573e-04  8.800904e-04
## ASV0936      2.205194e-03  2.308300e-03  2.416136e-03  2.528908e-03
## ASV12683     9.867904e-07  7.999712e-07  5.835566e-07  3.344292e-07
## ASV1293      1.501148e-03  1.569534e-03  1.640889e-03  1.715329e-03
## ASV13055    -4.286224e-05 -4.433976e-05 -4.583554e-05 -4.734579e-05
## ASV17063    -1.199506e-03 -1.254189e-03 -1.311249e-03 -1.370780e-03
## ASV2228      9.781521e-04  1.022739e-03  1.069264e-03  1.117802e-03
## ASV2769      1.425367e-04  1.497819e-04  1.574129e-04  1.654517e-04
## ASV2803      1.070706e-03  1.118711e-03  1.168728e-03  1.220827e-03
## ASV2896      8.296726e-04  8.685895e-04  9.093056e-04  9.519018e-04
## ASV3062      9.846205e-04  1.031951e-03  1.081573e-03  1.133601e-03
## ASV3107      1.550723e-03  1.623182e-03  1.698962e-03  1.778210e-03
## ASV3265      2.149484e-03  2.247298e-03  2.349346e-03  2.455794e-03
## ASV3666      2.193036e-05  2.286061e-05  2.382396e-05  2.482090e-05
## ASV4497      7.352478e-04  7.689165e-04  8.040635e-04  8.407479e-04
## ASV6914     -1.033219e-04 -1.084927e-04 -1.139328e-04 -1.196570e-04
## ASV0576     -2.598861e-03 -2.714888e-03 -2.835730e-03 -2.961554e-03
## ASV0673      2.824070e-03  2.953912e-03  3.089503e-03  3.231077e-03
## ASV0772      1.307426e-03  1.367758e-03  1.430783e-03  1.496614e-03
## ASV0862      9.820325e-05  1.046094e-04  1.114782e-04  1.188456e-04
## ASV0898      9.973832e-04  1.044646e-03  1.094136e-03  1.145955e-03
## ASV0910      1.159987e-03  1.214352e-03  1.271223e-03  1.330713e-03
## ASV0964     -9.781496e-04 -1.022123e-03 -1.067948e-03 -1.115693e-03
## ASV10059     8.158250e-04  8.547122e-04  8.954533e-04  9.381367e-04
## ASV10263    -1.826721e-03 -1.910052e-03 -1.997010e-03 -2.087739e-03
## ASV1088      2.075621e-03  2.172382e-03  2.273559e-03  2.379346e-03
## ASV1101      2.614162e-03  2.733239e-03  2.857483e-03  2.987094e-03
## ASV1183      6.822909e-04  7.139705e-04  7.470829e-04  7.816895e-04
## ASV11956     6.791751e-04  7.094309e-04  7.409359e-04  7.737329e-04
## ASV12774     4.703380e-05  4.861839e-05  5.021796e-05  5.182782e-05
## ASV1321      2.986469e-03  3.127012e-03  3.274089e-03  3.427997e-03
## ASV13793    -1.259501e-03 -1.316954e-03 -1.376908e-03 -1.439460e-03
## ASV14482     8.348411e-05  8.706523e-05  9.078197e-05  9.463792e-05
## ASV15483     5.091000e-04  5.329339e-04  5.578639e-04  5.839386e-04
## ASV2062      2.401200e-03  2.511643e-03  2.626984e-03  2.747423e-03
## ASV2132      1.939328e-03  2.029973e-03  2.124773e-03  2.223911e-03
## ASV2413      1.865311e-03  1.950512e-03  2.039434e-03  2.132226e-03
## ASV2490      5.786671e-03  6.047992e-03  6.320444e-03  6.604439e-03
## ASV2594      7.096567e-04  7.426130e-04  7.770627e-04  8.130700e-04
## ASV2822     -3.323675e-03 -3.475324e-03 -3.633577e-03 -3.798694e-03
## ASV2863      3.549021e-03  3.710058e-03  3.878029e-03  4.053200e-03
## ASV2910      1.295123e-03  1.354138e-03  1.415717e-03  1.479960e-03
## ASV2980      1.434420e-03  1.500507e-03  1.569534e-03  1.641622e-03
## ASV3307      2.644490e-03  2.765121e-03  2.891004e-03  3.022345e-03
## ASV3474      1.703910e-03  1.784521e-03  1.868917e-03  1.957276e-03
## ASV3502      1.815112e-03  1.899246e-03  1.987171e-03  2.079049e-03
## ASV4236      2.725898e-03  2.848669e-03  2.976635e-03  3.109985e-03
## ASV4842     -2.829113e-04 -2.963439e-04 -3.104081e-04 -3.251327e-04
## ASV4894     -1.259701e-03 -1.317173e-03 -1.377149e-03 -1.439725e-03
## ASV5290      9.853174e-04  1.031293e-03  1.079369e-03  1.129636e-03
## ASV5501      6.054253e-04  6.334567e-04  6.627503e-04  6.933598e-04
## ASV5795      6.613909e-04  6.922987e-04  7.246226e-04  7.584250e-04
## ASV5987     -3.518517e-03 -3.679062e-03 -3.846600e-03 -4.021406e-03
## ASV6267     -3.964471e-03 -4.145343e-03 -4.334092e-03 -4.531026e-03
## ASV6862      1.602156e-03  1.674530e-03  1.749990e-03  1.828652e-03
## ASV7145      7.119284e-04  7.437718e-04  7.769454e-04  8.114966e-04
## ASV7673     -1.259647e-03 -1.317115e-03 -1.377085e-03 -1.439656e-03
## ASV7789      5.961561e-04  6.251883e-04  6.556618e-04  6.876504e-04
## ASV7809      3.159968e-05  3.375381e-05  3.606957e-05  3.855980e-05
## ASV8002     -1.590871e-03 -1.663449e-03 -1.739186e-03 -1.818208e-03
## ASV8205      6.568644e-04  6.874390e-04  7.194037e-04  7.528189e-04
## ASV9155     -4.075128e-04 -4.259076e-04 -4.450847e-04 -4.650726e-04
## ASV9221      1.441784e-04  1.519963e-04  1.602740e-04  1.690411e-04
## ASV9311     -2.552001e-03 -2.668418e-03 -2.789904e-03 -2.916657e-03
## ASV9557     -1.744016e-03 -1.823565e-03 -1.906577e-03 -1.993188e-03
## ASV9936     -3.516876e-03 -3.677271e-03 -3.844646e-03 -4.019275e-03
## ASV1445      2.105142e-03  2.203197e-03  2.305715e-03  2.412891e-03
## ASV4232      7.834504e-04  8.207697e-04  8.598678e-04  9.008297e-04
## ASV6479      2.603413e-04  2.739866e-04  2.883955e-04  3.036144e-04
## ASV0142     -1.520078e-03 -1.589152e-03 -1.661208e-03 -1.736362e-03
## ASV0378      6.670631e-04  6.988706e-04  7.321956e-04  7.671103e-04
## ASV1122      2.032379e-03  2.127374e-03  2.226726e-03  2.330624e-03
## ASV0123     -1.343274e-03 -1.404255e-03 -1.467864e-03 -1.534200e-03
## ASV2064      6.977882e-04  7.288150e-04  7.611154e-04  7.947318e-04
## ASV4459     -1.009164e-04 -1.051953e-04 -1.096305e-04 -1.142254e-04
## ASV0448      5.330903e-04  5.585323e-04  5.851900e-04  6.131213e-04
## ASV0397      1.204707e-03  1.260388e-03  1.318563e-03  1.379337e-03
## ASV0485      1.407048e-03  1.471637e-03  1.539078e-03  1.609486e-03
## ASV1566      2.064579e-03  2.159881e-03  2.259438e-03  2.363429e-03
## ASV1365      1.755154e-03  1.836682e-03  1.921898e-03  2.010960e-03
## ASV1065      2.496885e-03  2.612693e-03  2.733725e-03  2.860206e-03
## ASV0722     -1.284986e-04 -1.345694e-04 -1.409253e-04 -1.475793e-04
## ASV12660    -1.458379e-03 -1.524408e-03 -1.593268e-03 -1.665066e-03
## ASV0223      3.881326e-04  4.059813e-04  4.246216e-04  4.440861e-04
## ASV0229      5.848604e-04  6.122208e-04  6.408384e-04  6.707689e-04
## ASV0877      2.556271e-04  2.669612e-04  2.787551e-04  2.910235e-04
## ASV0983      1.399441e-03  1.463514e-03  1.530399e-03  1.600209e-03
## ASV0626      1.303171e-04  1.375734e-04  1.452700e-04  1.534361e-04
## ASV4146      6.888097e-05  7.205065e-05  7.535854e-05  7.880972e-05
## ASV4175     -1.700367e-03 -1.779735e-03 -1.862732e-03 -1.949515e-03
## ASV2082     -7.278193e-04 -7.641112e-04 -8.022827e-04 -8.424371e-04
## ASV2272      8.114806e-04  8.492348e-04  8.887049e-04  9.299650e-04
## ASV2245     -1.211681e-03 -1.268410e-03 -1.327748e-03 -1.389810e-03
## ASV0590     -6.751591e-04 -7.095728e-04 -7.458325e-04 -7.840444e-04
## ASV0217      3.577423e-05  3.916687e-05  4.287513e-05  4.692751e-05
## ASV0416      9.602671e-04  1.002712e-03  1.046876e-03  1.092814e-03
## ASV1056      1.164871e-03  1.219836e-03  1.277369e-03  1.337588e-03
## ASV7777     -1.658869e-03 -1.736043e-03 -1.816722e-03 -1.901059e-03
## ASV0455      2.986088e-04  3.124483e-04  3.269111e-04  3.420237e-04
## ASV0604      7.629778e-04  7.992255e-04  8.371891e-04  8.769492e-04
## ASV6100     -1.137339e-03 -1.190603e-03 -1.246321e-03 -1.304601e-03
## ASV11359    -2.456573e-03 -2.570919e-03 -2.690461e-03 -2.815425e-03
## ASV6604      3.362166e-04  3.521455e-04  3.688244e-04  3.862883e-04
## ASV5004     -8.765702e-04 -9.171904e-04 -9.596408e-04 -1.003999e-03
## ASV1483     -3.785528e-04 -3.960371e-04 -4.143035e-04 -4.333844e-04
## ASV9773     -1.104328e-03 -1.155863e-03 -1.209755e-03 -1.266106e-03
## ASV4059     -1.842780e-05 -1.797928e-05 -1.738785e-05 -1.663596e-05
## ASV1193      1.343231e-03  1.405364e-03  1.470283e-03  1.538107e-03
## ASV4610     -2.406535e-04 -2.499270e-04 -2.594461e-04 -2.692056e-04
## ASV0742     -1.512971e-04 -1.567885e-04 -1.623853e-04 -1.680789e-04
## ASV1502     -4.548049e-05 -4.853328e-05 -5.181254e-05 -5.533618e-05
## ASV0195      4.170300e-05  4.304391e-05  4.439051e-05  4.573806e-05
## ASV1213      9.696473e-04  1.013028e-03  1.058218e-03  1.105280e-03
## ASV1648     -1.022309e-03 -1.070131e-03 -1.120150e-03 -1.172465e-03
## ASV6984     -9.561274e-04 -1.000874e-03 -1.047679e-03 -1.096635e-03
## ASV0396     -6.485032e-05 -6.719306e-05 -6.958018e-05 -7.200806e-05
## ASV4297      1.396711e-03  1.459810e-03  1.525599e-03  1.594177e-03
## ASV2622      2.149666e-03  2.247826e-03  2.350271e-03  2.457169e-03
## ASV3512      7.981339e-04  8.370107e-04  8.778191e-04  9.206582e-04
## ASV2411      1.428675e-03  1.496184e-03  1.566857e-03  1.640841e-03
## ASV2291     -5.785652e-04 -6.084029e-04 -6.398696e-04 -6.730612e-04
## ASV0807      1.977871e-03  2.069393e-03  2.165023e-03  2.264934e-03
## ASV1292      4.936767e-04  5.154873e-04  5.381809e-04  5.617858e-04
## ASV1035      1.838095e-03  1.921564e-03  2.008635e-03  2.099448e-03
## ASV0070      6.018618e-06  6.912852e-06  7.905906e-06  9.007529e-06
## ASV0255      1.771712e-04  1.850344e-04  1.932184e-04  2.017336e-04
## ASV0057     -5.108764e-04 -5.337593e-04 -5.575982e-04 -5.824267e-04
## ASV0077     -1.120193e-04 -1.168072e-04 -1.217726e-04 -1.269196e-04
## ASV0625      1.061436e-03  1.109458e-03  1.159533e-03  1.211738e-03
## ASV2464      7.237113e-03  7.563454e-03  7.903667e-03  8.258266e-03
## ASV1315      1.857641e-03  1.945668e-03  2.037845e-03  2.134363e-03
## ASV2673      1.592486e-03  1.668011e-03  1.747101e-03  1.829923e-03
## ASV2161      6.744341e-04  7.063501e-04  7.397669e-04  7.747542e-04
## ASV0337     -3.895606e-04 -4.077728e-04 -4.268200e-04 -4.467392e-04
## ASV7680     -2.539467e-03 -2.658372e-03 -2.782749e-03 -2.912841e-03
## ASV0611      1.417516e-03  1.483936e-03  1.553419e-03  1.626099e-03
## ASV3118     -1.456468e-03 -1.525750e-03 -1.598322e-03 -1.674339e-03
## ASV1284      5.914061e-04  6.147134e-04  6.386835e-04  6.633080e-04
## ASV0889      1.089062e-03  1.138948e-03  1.191028e-03  1.245389e-03
## ASV4649     -5.405040e-04 -5.656097e-04 -5.918520e-04 -6.192795e-04
## ASV1108     -1.083930e-03 -1.135874e-03 -1.190321e-03 -1.247392e-03
## ASV0738      5.851737e-04  6.141560e-04  6.446208e-04  6.766477e-04
## ASV0473     -1.130709e-04 -1.190921e-04 -1.254561e-04 -1.321840e-04
## ASV0598     -2.940813e-04 -3.089855e-04 -3.246829e-04 -3.412188e-04
## ASV0429      8.127507e-04  8.496932e-04  8.882304e-04  9.284233e-04
## ASV1549      1.468507e-03  1.538210e-03  1.611209e-03  1.687658e-03
## ASV1203      1.182366e-03  1.236674e-03  1.293383e-03  1.352589e-03
## ASV4532      5.507822e-05  5.731226e-05  5.961816e-05  6.199646e-05
## ASV0274      1.980907e-04  2.077383e-04  2.178639e-04  2.284915e-04
## ASV0163     -9.236390e-04 -9.653242e-04 -1.008783e-03 -1.054081e-03
## ASV1298      1.050935e-04  1.095482e-04  1.141664e-04  1.189519e-04
## ASV9424     -1.965177e-03 -2.057424e-03 -2.153939e-03 -2.254915e-03
## ASV0412      2.056260e-03  2.150348e-03  2.248564e-03  2.351070e-03
## ASV0284      4.434491e-04  4.627947e-04  4.828986e-04  5.037827e-04
## ASV0620     -4.000308e-04 -4.198656e-04 -4.407161e-04 -4.626370e-04
## ASV0153     -1.963474e-03 -2.056667e-03 -2.154265e-03 -2.256475e-03
## ASV0498      6.984691e-04  7.312187e-04  7.654780e-04  8.013141e-04
## ASV0097      3.858280e-04  4.041306e-04  4.232977e-04  4.433700e-04
## ASV0104     -2.776611e-03 -2.904764e-03 -3.038639e-03 -3.178472e-03
## ASV1282      9.685169e-04  1.012442e-03  1.058253e-03  1.106022e-03
## ASV3883     -7.378608e-04 -7.736341e-04 -8.111669e-04 -8.505475e-04
## ASV0801      3.727659e-04  3.902250e-04  4.084874e-04  4.275886e-04
## ASV1611     -1.755665e-03 -1.838526e-03 -1.925262e-03 -2.016050e-03
## ASV0227     -3.024098e-04 -3.177530e-04 -3.339119e-04 -3.509325e-04
## ASV0833      6.009457e-04  6.290255e-04  6.583912e-04  6.890990e-04
## ASV0718      2.693247e-03  2.818716e-03  2.949900e-03  3.087047e-03
## ASV1139      3.700784e-04  3.856711e-04  4.018185e-04  4.185301e-04
## ASV0766     -3.663837e-04 -3.841895e-04 -4.028742e-04 -4.224822e-04
## ASV2091      2.228109e-03  2.328988e-03  2.434187e-03  2.543868e-03
## ASV1238     -1.991875e-03 -2.085445e-03 -2.183353e-03 -2.285795e-03
## ASV9193     -1.730261e-04 -1.824740e-04 -1.924838e-04 -2.030925e-04
## ASV0290      2.995313e-04  3.124506e-04  3.258628e-04  3.397805e-04
## ASV0231      8.094491e-04  8.464902e-04  8.851555e-04  9.255096e-04
## ASV0185      4.497687e-04  4.719859e-04  4.953345e-04  5.198747e-04
## ASV2330      9.387948e-04  9.809477e-04  1.024872e-03  1.070631e-03
## ASV3119     -4.082843e-04 -4.283778e-04 -4.494875e-04 -4.716670e-04
## ASV2368     -1.015188e-03 -1.063407e-03 -1.113910e-03 -1.166807e-03
## ASV0122     -5.014742e-04 -5.245397e-04 -5.486278e-04 -5.737805e-04
## ASV1044      1.264771e-03  1.324476e-03  1.386974e-03  1.452394e-03
## ASV0160     -5.461366e-04 -5.706836e-04 -5.962649e-04 -6.229177e-04
## ASV0326      1.407609e-04  1.473511e-04  1.542440e-04  1.614530e-04
## ASV1388      2.597819e-03  2.717587e-03  2.842689e-03  2.973346e-03
## ASV0792      1.942372e-03  2.030833e-03  2.123133e-03  2.219421e-03
## ASV0036     -5.887890e-04 -6.167530e-04 -6.460401e-04 -6.767123e-04
## ASV2125      1.853142e-03  1.938864e-03  2.028431e-03  2.122006e-03
## ASV1075     -2.794480e-05 -2.922954e-05 -3.057181e-05 -3.197410e-05
## ASV0390      9.727685e-04  1.018923e-03  1.067259e-03  1.117880e-03
## ASV3790     -1.393846e-03 -1.459065e-03 -1.527281e-03 -1.598627e-03
## ASV1535     -3.902929e-04 -4.094111e-04 -4.294882e-04 -4.505742e-04
## ASV0263      1.714806e-03  1.794481e-03  1.877765e-03  1.964811e-03
## ASV0675      2.557283e-03  2.677521e-03  2.803339e-03  2.934989e-03
## ASV3348      2.035503e-04  2.133954e-04  2.237227e-04  2.345562e-04
## ASV0058     -7.691491e-04 -8.045506e-04 -8.415234e-04 -8.801320e-04
## ASV4142      1.086984e-03  1.136445e-03  1.188045e-03  1.241867e-03
## ASV0059     -6.210177e-04 -6.494980e-04 -6.792326e-04 -7.102721e-04
## ASV0013     -1.095453e-03 -1.146302e-03 -1.199450e-03 -1.254994e-03
## ASV0033     -5.124618e-04 -5.367521e-04 -5.621872e-04 -5.888206e-04
## ASV4354     -6.451277e-04 -6.750724e-04 -7.063726e-04 -7.390865e-04
## ASV0022     -4.329264e-04 -4.534333e-04 -4.749058e-04 -4.973885e-04
## ASV0134     -4.069674e-04 -4.265946e-04 -4.471783e-04 -4.687661e-04
## ASV0415      6.210936e-05  6.535434e-05  6.877892e-05  7.239371e-05
## ASV10103    -2.415888e-03 -2.529509e-03 -2.648406e-03 -2.772817e-03
## ASV1613      1.840638e-03  1.924533e-03  2.012074e-03  2.103401e-03
## ASV0135     -2.393823e-04 -2.500979e-04 -2.612604e-04 -2.728853e-04
## ASV0469     -2.365317e-03 -2.473838e-03 -2.587146e-03 -2.705435e-03
## ASV0471      1.430029e-03  1.496314e-03  1.565586e-03  1.637971e-03
## ASV0451     -2.174834e-04 -2.287155e-04 -2.405622e-04 -2.530597e-04
## ASV0747      8.100115e-04  8.478232e-04  8.873634e-04  9.287075e-04
## ASV1314     -8.032134e-04 -8.414152e-04 -8.814316e-04 -9.233484e-04
## ASV0425     -2.948474e-03 -3.082361e-03 -3.222020e-03 -3.367671e-03
## ASV0559     -7.210880e-04 -7.543803e-04 -7.891629e-04 -8.254987e-04
## ASV0148     -1.739575e-04 -1.812628e-04 -1.888252e-04 -1.966487e-04
## ASV0129      1.467933e-04  1.550584e-04  1.638351e-04  1.731583e-04
## ASV1072      2.001265e-04  2.089153e-04  2.180534e-04  2.275514e-04
## ASV2390      1.520433e-03  1.588830e-03  1.660111e-03  1.734380e-03
## ASV0548      9.850681e-04  1.030656e-03  1.078291e-03  1.128060e-03
## ASV0168     -5.089502e-04 -5.322798e-04 -5.566361e-04 -5.820605e-04
## ASV0066     -5.716590e-04 -5.979845e-04 -6.254795e-04 -6.541920e-04
## ASV0468     -3.006365e-04 -3.146241e-04 -3.292472e-04 -3.445333e-04
## ASV0172     -1.773104e-04 -1.850674e-04 -1.931300e-04 -2.015071e-04
## ASV0236     -5.933642e-05 -6.020910e-05 -6.094350e-05 -6.151706e-05
## ASV0250      7.776985e-04  8.154474e-04  8.550595e-04  8.966294e-04
## ASV0338      3.744414e-04  3.922439e-04  4.108890e-04  4.304158e-04
## ASV0450     -6.505464e-05 -6.849525e-05 -7.213092e-05 -7.597367e-05
## ASV0377      7.149873e-04  7.478526e-04  7.821729e-04  8.180074e-04
## ASV1022     -3.126858e-05 -3.265247e-05 -3.409169e-05 -3.558780e-05
## ASV6174     -1.274858e-05 -1.352560e-05 -1.435637e-05 -1.524507e-05
## ASV0786     -8.729808e-05 -9.216249e-05 -9.732180e-05 -1.027954e-04
## ASV0053     -7.670590e-04 -8.027596e-04 -8.400825e-04 -8.790976e-04
## ASV0697     -4.733746e-04 -4.949295e-04 -5.174200e-04 -5.408824e-04
## ASV0785      9.901382e-04  1.035671e-03  1.083220e-03  1.132870e-03
## ASV1967     -9.869944e-04 -1.032148e-03 -1.079283e-03 -1.128478e-03
## ASV0385      3.226622e-04  3.380850e-04  3.542460e-04  3.711804e-04
## ASV0295      4.982043e-05  5.271102e-05  5.578716e-05  5.906198e-05
## ASV0072     -7.730307e-04 -8.083334e-04 -8.451763e-04 -8.836198e-04
## ASV0157     -1.101082e-04 -1.143567e-04 -1.187151e-04 -1.231801e-04
## ASV0501      1.654228e-03  1.731357e-03  1.812004e-03  1.896323e-03
## ASV10729    -2.074014e-03 -2.171060e-03 -2.272565e-03 -2.378728e-03
## ASV1470      1.088204e-03  1.136982e-03  1.187801e-03  1.240733e-03
## ASV0050     -1.809227e-03 -1.892558e-03 -1.979593e-03 -2.070484e-03
## ASV0411     -4.011561e-04 -4.201245e-04 -4.399830e-04 -4.607726e-04
## ASV0549      6.474920e-04  6.779230e-04  7.097647e-04  7.430808e-04
## ASV0184      2.194267e-04  2.295275e-04  2.400776e-04  2.510956e-04
## ASV0705      4.364912e-04  4.564238e-04  4.772259e-04  4.989316e-04
## ASV1715      9.121442e-04  9.545587e-04  9.988970e-04  1.045242e-03
## ASV0603      1.406762e-04  1.473133e-04  1.542615e-04  1.615351e-04
## ASV0826      1.546996e-03  1.618446e-03  1.693093e-03  1.771069e-03
## ASV0034     -4.988465e-04 -5.216596e-04 -5.454713e-04 -5.703210e-04
## ASV0838      3.699113e-04  3.850856e-04  4.007544e-04  4.169205e-04
## ASV0614     -4.238765e-04 -4.434304e-04 -4.638572e-04 -4.851929e-04
## ASV0014     -1.120986e-03 -1.172867e-03 -1.227078e-03 -1.283717e-03
## ASV0585      1.469100e-04  1.521608e-04  1.575012e-04  1.629213e-04
## ASV0016     -1.171045e-03 -1.225242e-03 -1.281872e-03 -1.341040e-03
## ASV5394     -8.734290e-04 -9.141601e-04 -9.567498e-04 -1.001279e-03
## ASV0666      1.937428e-03  2.025584e-03  2.117557e-03  2.213496e-03
## ASV2085      4.792012e-04  4.987894e-04  5.190140e-04  5.398789e-04
## ASV0003     -7.988191e-04 -8.357687e-04 -8.743759e-04 -9.147103e-04
## ASV0346      3.936771e-04  4.124258e-04  4.320657e-04  4.526390e-04
## ASV0267     -1.092678e-05 -1.092346e-05 -1.087136e-05 -1.076380e-05
## ASV0353      6.298023e-04  6.595149e-04  6.906157e-04  7.231683e-04
## ASV2419      1.725128e-03  1.804548e-03  1.887496e-03  1.974118e-03
## ASV0447      9.220711e-04  9.656660e-04  1.011306e-03  1.059084e-03
## ASV0654      1.385541e-03  1.449737e-03  1.516822e-03  1.586919e-03
## ASV0151      1.757367e-04  1.844861e-04  1.936876e-04  2.033657e-04
## ASV0065     -5.383556e-04 -5.631538e-04 -5.890548e-04 -6.161039e-04
## ASV0527      1.320965e-03  1.381996e-03  1.445758e-03  1.512366e-03
## ASV4055     -2.020366e-04 -2.118188e-04 -2.220827e-04 -2.328527e-04
## ASV0166     -6.706669e-04 -7.011837e-04 -7.330221e-04 -7.662330e-04
## ASV0417     -2.789738e-04 -2.913671e-04 -3.042682e-04 -3.176938e-04
## ASV0078     -3.961800e-04 -4.142911e-04 -4.331940e-04 -4.529201e-04
## ASV0322     -7.892033e-05 -8.211945e-05 -8.541694e-05 -8.881228e-05
## ASV0156     -9.273755e-04 -9.707575e-04 -1.016133e-03 -1.063590e-03
## ASV0648     -2.009424e-03 -2.103722e-03 -2.202379e-03 -2.305590e-03
## ASV0407     -1.490446e-04 -1.561455e-04 -1.635849e-04 -1.713789e-04
## ASV2030     -3.409618e-04 -3.565206e-04 -3.727619e-04 -3.897135e-04
## ASV0300      2.374706e-04  2.487748e-04  2.606164e-04  2.730207e-04
## ASV1150      5.118832e-05  5.377377e-05  5.649557e-05  5.936133e-05
## ASV0958      7.331343e-04  7.680665e-04  8.046636e-04  8.430049e-04
## ASV0216     -8.332672e-04 -8.714858e-04 -9.113905e-04 -9.530498e-04
## ASV0446      1.238054e-03  1.296177e-03  1.356989e-03  1.420608e-03
## ASV0367     -8.151679e-04 -8.531664e-04 -8.928975e-04 -9.344367e-04
## ASV0200     -4.851962e-04 -5.077952e-04 -5.314228e-04 -5.561235e-04
## ASV0334     -2.777835e-04 -2.897404e-04 -3.021507e-04 -3.150261e-04
## ASV1311      3.308346e-04  3.454331e-04  3.606200e-04  3.764136e-04
## ASV0458      4.916639e-04  5.131728e-04  5.355321e-04  5.587670e-04
## ASV1371      7.379345e-05  7.741248e-05  8.121276e-05  8.520361e-05
## ASV0418      1.101038e-03  1.150977e-03  1.203064e-03  1.257381e-03
## ASV0004      1.599818e-04  1.672145e-04  1.747559e-04  1.826177e-04
## ASV1943      3.152376e-03  3.288935e-03  3.430782e-03  3.578064e-03
## ASV1495     -1.954383e-04 -2.059590e-04 -2.170924e-04 -2.288777e-04
## ASV0901     -9.089189e-04 -9.517321e-04 -9.965403e-04 -1.043434e-03
## ASV0628      5.007451e-04  5.231430e-04  5.464731e-04  5.707677e-04
## ASV0400      3.005742e-04  3.142841e-04  3.285903e-04  3.435159e-04
## ASV0116     -2.675349e-04 -2.801206e-04 -2.932910e-04 -3.070728e-04
## ASV0788      2.362286e-03  2.473585e-03  2.590072e-03  2.711984e-03
## ASV0117      1.718841e-04  1.801317e-04  1.887775e-04  1.978408e-04
## ASV3137     -5.653488e-05 -5.911429e-05 -6.180607e-05 -6.461463e-05
## ASV0001      1.721539e-04  1.799122e-04  1.879994e-04  1.964274e-04
## ASV1651      4.886588e-04  5.108030e-04  5.338976e-04  5.579785e-04
## ASV1692      1.968820e-03  2.061487e-03  2.158465e-03  2.259947e-03
## ASV0660      7.307483e-04  7.632380e-04  7.970603e-04  8.322591e-04
## ASV0508      3.707432e-05  3.869363e-05  4.037678e-05  4.212564e-05
## ASV1660     -3.871190e-04 -4.060056e-04 -4.258312e-04 -4.466435e-04
## ASV0233      6.128107e-04  6.413314e-04  6.711485e-04  7.023181e-04
## ASV1343     -1.122720e-03 -1.175462e-03 -1.230648e-03 -1.288388e-03
## ASV0209      5.752706e-04  6.012282e-04  6.282890e-04  6.564937e-04
## ASV0193     -6.696585e-04 -7.000073e-04 -7.316584e-04 -7.646609e-04
## ASV0357      2.410262e-04  2.530047e-04  2.656006e-04  2.788475e-04
## ASV0198      5.038788e-04  5.270212e-04  5.511867e-04  5.764167e-04
## ASV0007      1.528888e-04  1.597188e-04  1.668325e-04  1.742396e-04
## ASV1772     -2.292775e-04 -2.394142e-04 -2.499590e-04 -2.609244e-04
## ASV0009      1.271335e-04  1.327592e-04  1.386133e-04  1.447033e-04
## ASV0006     -1.319137e-04 -1.382219e-04 -1.448326e-04 -1.517606e-04
## ASV0011     -4.638566e-04 -4.855925e-04 -5.083301e-04 -5.321140e-04
## ASV0015      9.610766e-05  1.003597e-04  1.047842e-04  1.093867e-04
## ASV0017      1.082262e-04  1.130168e-04  1.180021e-04  1.231884e-04
## ASV0235     -4.275150e-04 -4.476240e-04 -4.686666e-04 -4.906848e-04
## ASV0382      3.345452e-04  3.502964e-04  3.667791e-04  3.840260e-04
## ASV2357      1.398236e-03  1.463694e-03  1.532163e-03  1.603777e-03
## ASV0567     -2.699746e-04 -2.826674e-04 -2.959503e-04 -3.098499e-04
## ASV0165      2.332729e-04  2.441961e-04  2.556218e-04  2.675723e-04
## ASV0005      3.412272e-04  3.570141e-04  3.735093e-04  3.907426e-04
## ASV0384     -4.354406e-05 -4.512312e-05 -4.673144e-05 -4.836625e-05
## ASV0002      6.463996e-05  6.757511e-05  7.063696e-05  7.383037e-05
## ASV3017      1.831337e-03  1.914417e-03  2.001071e-03  2.091433e-03
## ASV0091     -4.616583e-05 -4.827486e-05 -5.047637e-05 -5.277413e-05
## ASV0186     -6.862744e-04 -7.181289e-04 -7.514224e-04 -7.862163e-04
## ASV0370      3.665726e-04  3.834118e-04  4.009949e-04  4.193522e-04
## ASV0018      4.366099e-04  4.568453e-04  4.779921e-04  5.000888e-04
## ASV1377      4.427140e-03  4.628919e-03  4.839468e-03  5.059129e-03
## ASV0019      4.578794e-04  4.791116e-04  5.013011e-04  5.244884e-04
## ASV0023     -2.832371e-04 -2.965759e-04 -3.105355e-04 -3.251442e-04
## ASV2194      4.533420e-04  4.748199e-04  4.973104e-04  5.208609e-04
## ASV1155      1.855260e-03  1.939554e-03  2.027495e-03  2.119226e-03
## ASV0510     -5.056032e-04 -5.280366e-04 -5.513852e-04 -5.756788e-04
## ASV2371     -1.116733e-03 -1.167516e-03 -1.220498e-03 -1.275766e-03
## ASV0024     -3.531248e-04 -3.697247e-04 -3.870945e-04 -4.052689e-04
## ASV2452      1.134230e-03  1.185009e-03  1.237907e-03  1.292997e-03
## ASV2332     -3.195871e-03 -3.341951e-03 -3.494430e-03 -3.653564e-03
## ASV2591      7.924581e-04  8.317450e-04  8.730333e-04  9.164284e-04
## ASV0521      7.178742e-04  7.515889e-04  7.868647e-04  8.237718e-04
## ASV5542      6.864962e-04  7.188091e-04  7.526212e-04  7.879998e-04
## ASV0336     -7.903088e-05 -8.326431e-05 -8.774172e-05 -9.247839e-05
## ASV10102     1.269952e-03  1.329588e-03  1.391984e-03  1.457262e-03
## ASV16823    -2.021492e-03 -2.112189e-03 -2.206699e-03 -2.305162e-03
## ASV3104      1.045850e-02  1.092768e-02  1.141658e-02  1.192592e-02
## ASV0781      1.430244e-03  1.496449e-03  1.565629e-03  1.637910e-03
## ASV10899     8.007792e-04  8.404902e-04  8.822330e-04  9.261164e-04
## ASV11222    -3.557492e-03 -3.717074e-03 -3.883366e-03 -4.056609e-03
## ASV11327    -3.193651e-03 -3.336896e-03 -3.486162e-03 -3.641666e-03
## ASV12458    -3.556716e-03 -3.716227e-03 -3.882442e-03 -4.055601e-03
## ASV1636      1.984142e-03  2.074891e-03  2.169614e-03  2.268467e-03
## ASV1890     -1.658576e-03 -1.731417e-03 -1.807175e-03 -1.885940e-03
## ASV2898      2.659614e-03  2.781295e-03  2.908309e-03  3.040868e-03
## ASV8328      2.481714e-04  2.638794e-04  2.806862e-04  2.986744e-04
## ASV0709     -2.948715e-03 -3.084739e-03 -3.226826e-03 -3.375226e-03
## ASV0856      2.401464e-03  2.515358e-03  2.634625e-03  2.759515e-03
## ASV0909      6.542247e-04  6.878246e-04  7.232474e-04  7.605995e-04
## ASV0937     -1.714236e-03 -1.794526e-03 -1.878518e-03 -1.966377e-03
## ASV11390    -5.075740e-03 -5.303356e-03 -5.540534e-03 -5.787619e-03
## ASV11966     1.165017e-03  1.221019e-03  1.279729e-03  1.341280e-03
## ASV12990     8.766343e-04  9.166143e-04  9.583308e-04  1.001851e-03
## ASV14797     1.304685e-03  1.363760e-03  1.425364e-03  1.489594e-03
## ASV14904    -7.283357e-03 -7.609961e-03 -7.950286e-03 -8.304826e-03
## ASV15304     7.176701e-04  7.529923e-04  7.900954e-04  8.290721e-04
## ASV16696    -2.516330e-03 -2.629160e-03 -2.746728e-03 -2.869207e-03
## ASV1690      4.074417e-03  4.268152e-03  4.471061e-03  4.683573e-03
## ASV2029      2.904327e-03  3.037904e-03  3.177402e-03  3.323066e-03
## ASV2834      3.598490e-03  3.766645e-03  3.942505e-03  4.126408e-03
## ASV4003      2.897528e-03  3.036741e-03  3.182692e-03  3.335711e-03
## ASV4064      1.702118e-03  1.782023e-03  1.865621e-03  1.953077e-03
## ASV4294      9.944643e-04  1.043304e-03  1.094602e-03  1.148486e-03
## ASV4609      9.836345e-04  1.028815e-03  1.075990e-03  1.125239e-03
## ASV6283     -2.352336e-03 -2.457818e-03 -2.567732e-03 -2.682238e-03
## ASV6491     -3.371261e-03 -3.522417e-03 -3.679921e-03 -3.844003e-03
## ASV7453      1.541123e-03  1.615459e-03  1.693413e-03  1.775162e-03
## ASV7959      5.291484e-04  5.562701e-04  5.848545e-04  6.149854e-04
## ASV8219      2.913327e-02  3.043943e-02  3.180045e-02  3.321830e-02
## ASV8547     -3.017803e-03 -3.153088e-03 -3.294054e-03 -3.440904e-03
## ASV9319      1.261424e-03  1.321129e-03  1.383640e-03  1.449086e-03
## ASV9382     -5.904356e-03 -6.169025e-03 -6.444806e-03 -6.732098e-03
## ASV11516    -3.943207e-03 -4.119946e-03 -4.304102e-03 -4.495944e-03
## ASV14377    -2.846899e-03 -2.974485e-03 -3.107425e-03 -3.245911e-03
## ASV1867      2.130145e-03  2.230090e-03  2.334651e-03  2.444035e-03
## ASV1895      1.108443e-03  1.158144e-03  1.209923e-03  1.263851e-03
## ASV3168      1.383556e-03  1.446272e-03  1.511677e-03  1.579870e-03
## ASV4449      7.506089e-03  7.852851e-03  8.215150e-03  8.593640e-03
## ASV6596      1.506500e-03  1.579479e-03  1.656044e-03  1.736375e-03
## ASV7492     -3.361882e-04 -3.485342e-04 -3.611391e-04 -3.739870e-04
## ASV9854     -6.132551e-04 -6.404509e-04 -6.687636e-04 -6.982313e-04
## ASV6296      4.776617e-02  4.990656e-02  5.213673e-02  5.445991e-02
## ASV4201      1.704551e-04  1.816816e-04  1.937230e-04  2.066425e-04
## ASV0552      1.476731e-03  1.545850e-03  1.618147e-03  1.693762e-03
## ASV3671     -9.993714e-04 -1.045163e-03 -1.092976e-03 -1.142893e-03
## ASV3529     -3.009888e-04 -3.122700e-04 -3.238177e-04 -3.356220e-04
## ASV1060      3.880445e-04  4.064893e-04  4.258096e-04  4.460470e-04
## ASV0239     -5.508869e-04 -5.754615e-04 -6.010539e-04 -6.276991e-04
## ASV5711     -2.448875e-03 -2.560790e-03 -2.677607e-03 -2.799523e-03
## ASV4152     -3.421461e-03 -3.580399e-03 -3.746537e-03 -3.920185e-03
## ASV1461      1.771953e-03  1.851355e-03  1.934079e-03  2.020241e-03
## ASV2877      9.158281e-04  9.571416e-04  1.000208e-03  1.045093e-03
## ASV0012      1.548269e-04  1.620059e-04  1.695087e-04  1.773492e-04
## ASV9823      2.366474e-04  2.466201e-04  2.569465e-04  2.676322e-04
## ASV0008      1.656229e-04  1.732735e-04  1.812666e-04  1.896165e-04
## ASV7832     -2.010463e-03 -2.104053e-03 -2.201905e-03 -2.304207e-03
## ASV1915     -2.611053e-04 -2.728672e-04 -2.851312e-04 -2.979166e-04
## ASV0055     -1.706673e-04 -1.790425e-04 -1.878390e-04 -1.970788e-04
## ASV0032      8.718223e-05  9.093193e-05  9.482346e-05  9.886032e-05
## ASV2977     -2.843218e-03 -2.975024e-03 -3.112776e-03 -3.256726e-03
## ASV0466      2.343817e-03  2.448874e-03  2.558330e-03  2.672341e-03
## ASV3866      1.544162e-03  1.616852e-03  1.692924e-03  1.772531e-03
## ASV0040      5.617765e-04  5.879768e-04  6.153730e-04  6.440175e-04
## ASV0496     -1.093530e-04 -1.159370e-04 -1.229602e-04 -1.304547e-04
## ASV0052      4.713376e-04  4.933404e-04  5.163492e-04  5.404082e-04
## ASV3828     -1.693921e-03 -1.769701e-03 -1.848648e-03 -1.930874e-03
## ASV1930      8.572753e-04  8.963603e-04  9.371429e-04  9.796888e-04
## ASV2126      1.450611e-03  1.517366e-03  1.587083e-03  1.659885e-03
## ASV0793      1.752424e-03  1.834729e-03  1.920846e-03  2.010943e-03
## ASV0299     -3.392795e-05 -3.553821e-05 -3.722655e-05 -3.899711e-05
## ASV0208      1.272428e-03  1.331747e-03  1.393772e-03  1.458621e-03
## ASV0511     -5.417719e-04 -5.659190e-04 -5.910623e-04 -6.172354e-04
## ASV1123     -1.634252e-03 -1.707346e-03 -1.783488e-03 -1.862783e-03
## ASV0099      4.478720e-05  4.704073e-05  4.941330e-05  5.191174e-05
## ASV0752     -8.917183e-04 -9.341657e-04 -9.786299e-04 -1.025206e-03
## ASV0883      1.225535e-03  1.283724e-03  1.344664e-03  1.408485e-03
## ASV0683      1.609388e-03  1.685345e-03  1.764854e-03  1.848075e-03
## ASV4117     -2.589662e-03 -2.710253e-03 -2.836337e-03 -2.968154e-03
## ASV2172      1.790055e-04  1.866824e-04  1.946459e-04  2.029025e-04
## ASV0330     -4.818064e-04 -5.043739e-04 -5.279809e-04 -5.526734e-04
## ASV0728      2.399685e-03  2.510936e-03  2.627198e-03  2.748683e-03
## ASV0499      6.253373e-04  6.549053e-04  6.858612e-04  7.182689e-04
## ASV0120     -1.063337e-03 -1.112692e-03 -1.164277e-03 -1.218186e-03
## ASV1446      8.615219e-04  8.987195e-04  9.373406e-04  9.774226e-04
## ASV17171    -2.058969e-03 -2.154182e-03 -2.253673e-03 -2.357620e-03
## ASV0533      1.478472e-04  1.550190e-04  1.625441e-04  1.704402e-04
## ASV2495     -4.791881e-04 -5.028417e-04 -5.277019e-04 -5.538336e-04
## ASV5582      9.901075e-04  1.033605e-03  1.078837e-03  1.125859e-03
## ASV1488      3.685755e-04  3.853382e-04  4.028251e-04  4.210638e-04
## ASV0682      4.543899e-04  4.759517e-04  4.985322e-04  5.221792e-04
## ASV0068     -8.037100e-04 -8.411094e-04 -8.802071e-04 -9.210766e-04
## ASV1987     -1.963243e-03 -2.056870e-03 -2.154963e-03 -2.257732e-03
## ASV0035     -1.330530e-04 -1.401631e-04 -1.476842e-04 -1.556425e-04
## ASV7192     -1.260035e-03 -1.317718e-03 -1.377935e-03 -1.440788e-03
## ASV0873      1.547792e-04  1.436610e-04  1.303725e-04  1.146731e-04
## ASV4749      9.236319e-06  6.670836e-06  3.707204e-06  3.020069e-07
## ASV2174      8.994575e-04  9.392575e-04  9.806730e-04  1.023756e-03
## ASV1476     -8.751618e-04 -9.165756e-04 -9.599391e-04 -1.005343e-03
## ASV0740     -2.486282e-03 -2.603914e-03 -2.727072e-03 -2.856014e-03
## ASV0170     -4.927989e-04 -5.157387e-04 -5.397216e-04 -5.647926e-04
## ASV2466     -2.246919e-03 -2.351475e-03 -2.460786e-03 -2.575058e-03
## ASV1709      8.402255e-04  8.782975e-04  9.180113e-04  9.594312e-04
## ASV6170     -3.490652e-03 -3.654770e-03 -3.826503e-03 -4.006197e-03
## ASV3673      1.706158e-03  1.786862e-03  1.871357e-03  1.959817e-03
## ASV1745     -4.342308e-04 -4.552329e-04 -4.772642e-04 -5.003762e-04
##                                                                    
## (Intercept)  1.435460e-02  1.502044e-02  1.571630e-02  1.644345e-02
## ASV1236      2.872135e-03  3.002082e-03  3.137596e-03  3.278884e-03
## ASV0421      3.040053e-04  3.198799e-04  3.366354e-04  3.543245e-04
## ASV0691     -2.283118e-03 -2.382156e-03 -2.485035e-03 -2.591863e-03
## ASV0899      2.484296e-03  2.597164e-03  2.714900e-03  2.837690e-03
## ASV1004      5.743453e-03  6.003993e-03  6.275744e-03  6.559135e-03
## ASV1041     -2.365394e-03 -2.472429e-03 -2.584038e-03 -2.700390e-03
## ASV1058      3.586967e-03  3.749471e-03  3.918952e-03  4.095673e-03
## ASV12542     1.400347e-03  1.462937e-03  1.528134e-03  1.596030e-03
## ASV1294      3.336626e-03  3.487932e-03  3.645746e-03  3.810317e-03
## ASV13113     1.085349e-03  1.137223e-03  1.191583e-03  1.248548e-03
## ASV1318      3.327982e-03  3.478830e-03  3.636159e-03  3.800215e-03
## ASV2269     -5.767954e-03 -6.028939e-03 -6.301088e-03 -6.584820e-03
## ASV2542      2.763221e-03  2.892536e-03  3.027798e-03  3.169270e-03
## ASV2660     -2.299283e-03 -2.402955e-03 -2.511029e-03 -2.623667e-03
## ASV2737      8.059378e-04  8.413715e-04  8.782266e-04  9.165480e-04
## ASV2840      3.086729e-03  3.224005e-03  3.366925e-03  3.515679e-03
## ASV3053      1.574691e-02  1.645185e-02  1.718625e-02  1.795117e-02
## ASV3077      1.003192e-03  1.048201e-03  1.095102e-03  1.143963e-03
## ASV3134      1.741134e-03  1.823570e-03  1.909886e-03  2.000263e-03
## ASV3140      2.387631e-03  2.498192e-03  2.613723e-03  2.734435e-03
## ASV3579      8.249156e-04  8.650619e-04  9.071967e-04  9.514211e-04
## ASV6119     -1.578458e-03 -1.649869e-03 -1.724334e-03 -1.801967e-03
## ASV7557     -3.207378e-03 -3.352462e-03 -3.503749e-03 -3.661472e-03
## ASV8422      8.032243e-04  8.392130e-04  8.767100e-04  9.157690e-04
## ASV1086     -1.286269e-04 -1.340864e-04 -1.397468e-04 -1.456126e-04
## ASV1310      1.536005e-03  1.605575e-03  1.678127e-03  1.753774e-03
## ASV15750    -2.126478e-04 -2.219491e-04 -2.316175e-04 -2.416635e-04
## ASV16905    -6.595448e-04 -6.893790e-04 -7.204886e-04 -7.529215e-04
## ASV2033      2.765427e-03  2.895709e-03  3.032056e-03  3.174744e-03
## ASV2089      1.390338e-03  1.453270e-03  1.518896e-03  1.587317e-03
## ASV2127      4.514516e-03  4.718969e-03  4.932190e-03  5.154510e-03
## ASV2725      3.627173e-03  3.789970e-03  3.959610e-03  4.136339e-03
## ASV2804     -1.365262e-03 -1.427015e-03 -1.491407e-03 -1.558538e-03
## ASV3075      2.969479e-03  3.106135e-03  3.248868e-03  3.397930e-03
## ASV3327      4.078835e-03  4.269418e-03  4.468733e-03  4.677161e-03
## ASV3342      3.512118e-03  3.675551e-03  3.846411e-03  4.025020e-03
## ASV3532     -3.887457e-03 -4.067104e-03 -4.254801e-03 -4.450886e-03
## ASV3600      1.804657e-03  1.888287e-03  1.975686e-03  2.067015e-03
## ASV4013      3.385713e-03  3.540643e-03  3.702367e-03  3.871158e-03
## ASV4136      3.639460e-03  3.803004e-03  3.973447e-03  4.151041e-03
## ASV4195      1.393510e-02  1.456530e-02  1.522243e-02  1.590750e-02
## ASV4407     -5.383592e-03 -5.627025e-03 -5.880858e-03 -6.145479e-03
## ASV4717      9.512078e-04  9.927535e-04  1.035939e-03  1.080813e-03
## ASV6794      2.246364e-03  2.346336e-03  2.450437e-03  2.558807e-03
## ASV8324     -2.762449e-03 -2.887361e-03 -3.017610e-03 -3.153395e-03
## ASV8981     -7.744905e-05 -8.001667e-05 -8.260406e-05 -8.520312e-05
## ASV9859      9.232914e-04  9.686684e-04  1.016336e-03  1.066414e-03
## ASV0936      2.646834e-03  2.770137e-03  2.899052e-03  3.033822e-03
## ASV12683     4.920164e-08 -2.758021e-07 -6.445657e-07 -1.061400e-06
## ASV1293      1.792972e-03  1.873940e-03  1.958358e-03  2.046355e-03
## ASV13055    -4.886610e-05 -5.039147e-05 -5.191617e-05 -5.343370e-05
## ASV17063    -1.432875e-03 -1.497634e-03 -1.565157e-03 -1.635546e-03
## ASV2228      1.168431e-03  1.221231e-03  1.276283e-03  1.333672e-03
## ASV2769      1.739212e-04  1.828460e-04  1.922521e-04  2.021669e-04
## ASV2803      1.275082e-03  1.331565e-03  1.390353e-03  1.451522e-03
## ASV2896      9.964626e-04  1.043076e-03  1.091833e-03  1.142831e-03
## ASV3062      1.188151e-03  1.245348e-03  1.305322e-03  1.368208e-03
## ASV3107      1.861079e-03  1.947725e-03  2.038315e-03  2.133020e-03
## ASV3265      2.566809e-03  2.682562e-03  2.803232e-03  2.928998e-03
## ASV3666      2.585185e-05  2.691711e-05  2.801690e-05  2.915130e-05
## ASV4497      8.790304e-04  9.189739e-04  9.606430e-04  1.004104e-03
## ASV6914     -1.256810e-04 -1.320214e-04 -1.386959e-04 -1.457231e-04
## ASV0576     -3.092528e-03 -3.228823e-03 -3.370614e-03 -3.518074e-03
## ASV0673      3.378878e-03  3.533154e-03  3.694162e-03  3.862169e-03
## ASV0772      1.565368e-03  1.637162e-03  1.712123e-03  1.790378e-03
## ASV0862      1.267500e-04  1.352332e-04  1.443400e-04  1.541189e-04
## ASV0898      1.200211e-03  1.257017e-03  1.316491e-03  1.378756e-03
## ASV0910      1.392939e-03  1.458020e-03  1.526084e-03  1.597262e-03
## ASV0964     -1.165425e-03 -1.217213e-03 -1.271128e-03 -1.327241e-03
## ASV10059     9.828548e-04  1.029704e-03  1.078787e-03  1.130208e-03
## ASV10263    -2.182383e-03 -2.281094e-03 -2.384024e-03 -2.491332e-03
## ASV1088      2.489945e-03  2.605563e-03  2.726420e-03  2.852740e-03
## ASV1101      3.122279e-03  3.263248e-03  3.410219e-03  3.563414e-03
## ASV1183      8.178540e-04  8.556423e-04  8.951228e-04  9.363666e-04
## ASV11956     8.078651e-04  8.433760e-04  8.803100e-04  9.187115e-04
## ASV12774     5.344261e-05  5.505625e-05  5.666183e-05  5.825157e-05
## ASV1321      3.589044e-03  3.757553e-03  3.933859e-03  4.118314e-03
## ASV13793    -1.504712e-03 -1.572766e-03 -1.643730e-03 -1.717711e-03
## ASV14482     9.863657e-05  1.027814e-04  1.070758e-04  1.115231e-04
## ASV15483     6.112085e-04  6.397261e-04  6.695462e-04  7.007255e-04
## ASV2062      2.873166e-03  3.004429e-03  3.141431e-03  3.284401e-03
## ASV2132      2.327578e-03  2.435970e-03  2.549295e-03  2.667765e-03
## ASV2413      2.229038e-03  2.330027e-03  2.435354e-03  2.545182e-03
## ASV2490      6.900400e-03  7.208758e-03  7.529955e-03  7.864440e-03
## ASV2594      8.507020e-04  8.900283e-04  9.311211e-04  9.740556e-04
## ASV2822     -3.970942e-03 -4.150592e-03 -4.337928e-03 -4.533235e-03
## ASV2863      4.235843e-03  4.426236e-03  4.624666e-03  4.831424e-03
## ASV2910      1.546968e-03  1.616848e-03  1.689709e-03  1.765660e-03
## ASV2980      1.716897e-03  1.795487e-03  1.877528e-03  1.963156e-03
## ASV3307      3.159353e-03  3.302247e-03  3.451249e-03  3.606589e-03
## ASV3474      2.049779e-03  2.146617e-03  2.247992e-03  2.354110e-03
## ASV3502      2.175046e-03  2.275336e-03  2.380096e-03  2.489514e-03
## ASV4236      3.248911e-03  3.393610e-03  3.544282e-03  3.701130e-03
## ASV4842     -3.405474e-04 -3.566833e-04 -3.735725e-04 -3.912486e-04
## ASV4894     -1.505003e-03 -1.573087e-03 -1.644082e-03 -1.718099e-03
## ASV5290      1.182190e-03  1.237130e-03  1.294558e-03  1.354582e-03
## ASV5501      7.253411e-04  7.587521e-04  7.936530e-04  8.301061e-04
## ASV5795      7.937706e-04  8.307267e-04  8.693633e-04  9.097531e-04
## ASV5987     -4.203761e-03 -4.393955e-03 -4.592287e-03 -4.799060e-03
## ASV6267     -4.736463e-03 -4.950729e-03 -5.174159e-03 -5.407097e-03
## ASV6862      1.910631e-03  1.996050e-03  2.085030e-03  2.177697e-03
## ASV7145      8.474734e-04  8.849251e-04  9.239018e-04  9.644542e-04
## ASV7673     -1.504928e-03 -1.573006e-03 -1.643994e-03 -1.718003e-03
## ASV7789      7.212318e-04  7.564879e-04  7.935050e-04  8.323739e-04
## ASV7809      4.123839e-05  4.412033e-05  4.722179e-05  5.056024e-05
## ASV8002     -1.900642e-03 -1.986617e-03 -2.076270e-03 -2.169737e-03
## ASV8205      7.877470e-04  8.242531e-04  8.624045e-04  9.022714e-04
## ASV9155     -4.859010e-04 -5.075997e-04 -5.301994e-04 -5.537313e-04
## ASV9221      1.783294e-04  1.881728e-04  1.986075e-04  2.096724e-04
## ASV9311     -3.048882e-03 -3.186788e-03 -3.330591e-03 -3.480512e-03
## ASV9557     -2.083535e-03 -2.177764e-03 -2.276021e-03 -2.378457e-03
## ASV9936     -4.201438e-03 -4.391423e-03 -4.589528e-03 -4.796055e-03
## ASV1445      2.524924e-03  2.642025e-03  2.764409e-03  2.892302e-03
## ASV4232      9.437446e-04  9.887056e-04  1.035811e-03  1.085162e-03
## ASV6479      3.196926e-04  3.366827e-04  3.546409e-04  3.736268e-04
## ASV0142     -1.814730e-03 -1.896434e-03 -1.981597e-03 -2.070347e-03
## ASV0378      8.036906e-04  8.420157e-04  8.821687e-04  9.242365e-04
## ASV1122      2.439269e-03  2.552868e-03  2.671636e-03  2.795799e-03
## ASV0123     -1.603368e-03 -1.675472e-03 -1.750621e-03 -1.828925e-03
## ASV2064      8.297069e-04  8.660837e-04  9.039057e-04  9.432162e-04
## ASV4459     -1.189832e-04 -1.239069e-04 -1.289993e-04 -1.342629e-04
## ASV0448      6.423871e-04  6.730509e-04  7.051796e-04  7.388429e-04
## ASV0397      1.442817e-03  1.509116e-03  1.578348e-03  1.650635e-03
## ASV0485      1.682981e-03  1.759686e-03  1.839729e-03  1.923240e-03
## ASV1566      2.472036e-03  2.585448e-03  2.703863e-03  2.827480e-03
## ASV1365      2.104032e-03  2.201282e-03  2.302888e-03  2.409029e-03
## ASV1065      2.992364e-03  3.130439e-03  3.274678e-03  3.425338e-03
## ASV0722     -1.545455e-04 -1.618384e-04 -1.694730e-04 -1.774654e-04
## ASV12660    -1.739911e-03 -1.817917e-03 -1.899197e-03 -1.983871e-03
## ASV0223      4.644082e-04  4.856228e-04  5.077657e-04  5.308739e-04
## ASV0229      7.020704e-04  7.348032e-04  7.690300e-04  8.048162e-04
## ASV0877      3.037805e-04  3.170406e-04  3.308179e-04  3.451266e-04
## ASV0983      1.673059e-03  1.749068e-03  1.828359e-03  1.911059e-03
## ASV0626      1.621028e-04  1.713033e-04  1.810734e-04  1.914511e-04
## ASV4146      8.240931e-05  8.616247e-05  9.007437e-05  9.415018e-05
## ASV4175     -2.040251e-03 -2.135111e-03 -2.234273e-03 -2.337921e-03
## ASV2082     -8.846835e-04 -9.291376e-04 -9.759220e-04 -1.025166e-03
## ASV2272      9.730925e-04  1.018168e-03  1.065273e-03  1.114497e-03
## ASV2245     -1.454717e-03 -1.522594e-03 -1.593572e-03 -1.667784e-03
## ASV0590     -8.243213e-04 -8.667829e-04 -9.115565e-04 -9.587770e-04
## ASV0217      5.135499e-05  5.619120e-05  6.147260e-05  6.723876e-05
## ASV0416      1.140581e-03  1.190232e-03  1.241822e-03  1.295407e-03
## ASV1056      1.400614e-03  1.466576e-03  1.535606e-03  1.607845e-03
## ASV7777     -1.989210e-03 -2.081340e-03 -2.177617e-03 -2.278218e-03
## ASV0455      3.578133e-04  3.743084e-04  3.915382e-04  4.095331e-04
## ASV0604      9.185898e-04  9.621990e-04  1.007869e-03  1.055695e-03
## ASV6100     -1.365557e-03 -1.429308e-03 -1.495977e-03 -1.565691e-03
## ASV11359    -2.946044e-03 -3.082559e-03 -3.225222e-03 -3.374293e-03
## ASV6604      4.045735e-04  4.237181e-04  4.437617e-04  4.647459e-04
## ASV5004     -1.050346e-03 -1.098765e-03 -1.149342e-03 -1.202168e-03
## ASV1483     -4.533136e-04 -4.741260e-04 -4.958577e-04 -5.185461e-04
## ASV9773     -1.325024e-03 -1.386619e-03 -1.451008e-03 -1.518312e-03
## ASV4059     -1.570434e-05 -1.457183e-05 -1.321523e-05 -1.160917e-05
## ASV1193      1.608956e-03  1.682956e-03  1.760238e-03  1.840934e-03
## ASV4610     -2.791988e-04 -2.894176e-04 -2.998517e-04 -3.104889e-04
## ASV0742     -1.738590e-04 -1.797139e-04 -1.856300e-04 -1.915914e-04
## ASV1502     -5.912354e-05 -6.319551e-05 -6.757462e-05 -7.228522e-05
## ASV0195      4.708120e-05  4.841389e-05  4.972934e-05  5.101996e-05
## ASV1213      1.154278e-03  1.205278e-03  1.258346e-03  1.313549e-03
## ASV1648     -1.227176e-03 -1.284389e-03 -1.344215e-03 -1.406767e-03
## ASV6984     -1.147836e-03 -1.201381e-03 -1.257376e-03 -1.315926e-03
## ASV0396     -7.447242e-05 -7.696831e-05 -7.949005e-05 -8.203114e-05
## ASV4297      1.665645e-03  1.740109e-03  1.817673e-03  1.898448e-03
## ASV2622      2.568695e-03  2.685027e-03  2.806349e-03  2.932850e-03
## ASV3512      9.656325e-04  1.012852e-03  1.062433e-03  1.114498e-03
## ASV2411      1.718286e-03  1.799352e-03  1.884205e-03  1.973019e-03
## ASV2291     -7.080794e-04 -7.450325e-04 -7.840356e-04 -8.252110e-04
## ASV0807      2.369306e-03  2.478324e-03  2.592179e-03  2.711070e-03
## ASV1292      5.863306e-04  6.118437e-04  6.383540e-04  6.658900e-04
## ASV1035      2.194144e-03  2.292871e-03  2.395778e-03  2.503018e-03
## ASV0070      1.022836e-05  1.158002e-05  1.307516e-05  1.472757e-05
## ASV0255      2.105904e-04  2.197994e-04  2.293708e-04  2.393152e-04
## ASV0057     -6.082789e-04 -6.351892e-04 -6.631930e-04 -6.923255e-04
## ASV0077     -1.322519e-04 -1.377729e-04 -1.434861e-04 -1.493943e-04
## ASV0625      1.266153e-03  1.322857e-03  1.381933e-03  1.443465e-03
## ASV2464      8.627777e-03  9.012738e-03  9.413699e-03  9.831222e-03
## ASV1315      2.235424e-03  2.341240e-03  2.452031e-03  2.568027e-03
## ASV2673      1.916650e-03  2.007465e-03  2.102558e-03  2.202128e-03
## ASV2161      8.113849e-04  8.497351e-04  8.898844e-04  9.319158e-04
## ASV0337     -4.675686e-04 -4.893478e-04 -5.121184e-04 -5.359231e-04
## ASV7680     -3.048899e-03 -3.191188e-03 -3.339981e-03 -3.495563e-03
## ASV0611      1.702119e-03  1.781628e-03  1.864779e-03  1.951733e-03
## ASV3118     -1.753962e-03 -1.837362e-03 -1.924717e-03 -2.016213e-03
## ASV1284      6.885748e-04  7.144679e-04  7.409662e-04  7.680436e-04
## ASV0889      1.302124e-03  1.361324e-03  1.423088e-03  1.487515e-03
## ASV4649     -6.479430e-04 -6.778948e-04 -7.091895e-04 -7.418835e-04
## ASV1108     -1.307215e-03 -1.369924e-03 -1.435659e-03 -1.504567e-03
## ASV0738      7.103210e-04  7.457294e-04  7.829673e-04  8.221338e-04
## ASV0473     -1.392982e-04 -1.468223e-04 -1.547817e-04 -1.632031e-04
## ASV0598     -3.586412e-04 -3.770013e-04 -3.963532e-04 -4.167546e-04
## ASV0429      9.703346e-04  1.014028e-03  1.059570e-03  1.107027e-03
## ASV1549      1.767718e-03  1.851559e-03  1.939358e-03  2.031298e-03
## ASV1203      1.414393e-03  1.478900e-03  1.546215e-03  1.616449e-03
## ASV4532      6.444749e-05  6.697139e-05  6.956805e-05  7.223712e-05
## ASV0274      2.396468e-04  2.513564e-04  2.636484e-04  2.765525e-04
## ASV0163     -1.101286e-03 -1.150466e-03 -1.201691e-03 -1.255033e-03
## ASV1298      1.239083e-04  1.290391e-04  1.343478e-04  1.398374e-04
## ASV9424     -2.360550e-03 -2.471054e-03 -2.586643e-03 -2.707544e-03
## ASV0412      2.458037e-03  2.569640e-03  2.686059e-03  2.807479e-03
## ASV0284      5.254682e-04  5.479765e-04  5.713282e-04  5.955437e-04
## ASV0620     -4.856859e-04 -5.099236e-04 -5.354146e-04 -5.622268e-04
## ASV0153     -2.363512e-03 -2.475601e-03 -2.592978e-03 -2.715890e-03
## ASV0498      8.387966e-04  8.779981e-04  9.189940e-04  9.618628e-04
## ASV0097      4.643897e-04  4.864012e-04  5.094506e-04  5.335865e-04
## ASV0104     -3.324511e-03 -3.477009e-03 -3.636227e-03 -3.802439e-03
## ASV1282      1.155821e-03  1.207725e-03  1.261810e-03  1.318153e-03
## ASV3883     -8.918689e-04 -9.352286e-04 -9.807292e-04 -1.028479e-03
## ASV0801      4.475658e-04  4.684574e-04  4.903034e-04  5.131455e-04
## ASV1611     -2.111076e-03 -2.210534e-03 -2.314626e-03 -2.423563e-03
## ASV0227     -3.688638e-04 -3.877578e-04 -4.076692e-04 -4.286566e-04
## ASV0833      7.212076e-04  7.547779e-04  7.898731e-04  8.265590e-04
## ASV0718      3.230417e-03  3.380276e-03  3.536904e-03  3.700590e-03
## ASV1139      4.358145e-04  4.536793e-04  4.721304e-04  4.911725e-04
## ASV0766     -4.430602e-04 -4.646572e-04 -4.873246e-04 -5.111166e-04
## ASV2091      2.658197e-03  2.777344e-03  2.901483e-03  3.030791e-03
## ASV1238     -2.392975e-03 -2.505108e-03 -2.622416e-03 -2.745130e-03
## ASV9193     -2.143394e-04 -2.262669e-04 -2.389204e-04 -2.523482e-04
## ASV0290      3.542163e-04  3.691824e-04  3.846904e-04  4.007518e-04
## ASV0231      9.676192e-04  1.011553e-03  1.057382e-03  1.105178e-03
## ASV0185      5.456704e-04  5.727889e-04  6.013015e-04  6.312833e-04
## ASV2330      1.118289e-03  1.167911e-03  1.219565e-03  1.273317e-03
## ASV3119     -4.949728e-04 -5.194645e-04 -5.452051e-04 -5.722612e-04
## ASV2368     -1.222210e-03 -1.280237e-03 -1.341012e-03 -1.404665e-03
## ASV0122     -6.000410e-04 -6.274539e-04 -6.560653e-04 -6.859228e-04
## ASV1044      1.520869e-03  1.592539e-03  1.667551e-03  1.746056e-03
## ASV0160     -6.506799e-04 -6.795903e-04 -7.096882e-04 -7.410135e-04
## ASV0326      1.689917e-04  1.768747e-04  1.851169e-04  1.937336e-04
## ASV1388      3.109786e-03  3.252244e-03  3.400963e-03  3.556194e-03
## ASV0792      2.319849e-03  2.424575e-03  2.533760e-03  2.647570e-03
## ASV0036     -7.088344e-04 -7.424741e-04 -7.777023e-04 -8.145930e-04
## ASV2125      2.219754e-03  2.321850e-03  2.428472e-03  2.539806e-03
## ASV1075     -3.343904e-05 -3.496934e-05 -3.656786e-05 -3.823759e-05
## ASV0390      1.170891e-03  1.226406e-03  1.284542e-03  1.345421e-03
## ASV3790     -1.673241e-03 -1.751267e-03 -1.832854e-03 -1.918158e-03
## ASV1535     -4.727215e-04 -4.959856e-04 -5.204251e-04 -5.461016e-04
## ASV0263      2.055782e-03  2.150844e-03  2.250169e-03  2.353937e-03
## ASV0675      3.072734e-03  3.216847e-03  3.367615e-03  3.525335e-03
## ASV3348      2.459212e-04  2.578442e-04  2.703533e-04  2.834775e-04
## ASV0058     -9.204428e-04 -9.625246e-04 -1.006448e-03 -1.052287e-03
## ASV4142      1.297995e-03  1.356516e-03  1.417517e-03  1.481089e-03
## ASV0059     -7.426683e-04 -7.764750e-04 -8.117474e-04 -8.485423e-04
## ASV0013     -1.313036e-03 -1.373681e-03 -1.437040e-03 -1.503224e-03
## ASV0033     -6.167078e-04 -6.459071e-04 -6.764791e-04 -7.084874e-04
## ASV4354     -7.732749e-04 -8.090007e-04 -8.463293e-04 -8.853287e-04
## ASV0022     -5.209285e-04 -5.455745e-04 -5.713779e-04 -5.983919e-04
## ASV0134     -4.914075e-04 -5.151549e-04 -5.400632e-04 -5.661902e-04
## ASV0415      7.620992e-05  8.023946e-05  8.449497e-05  8.898982e-05
## ASV10103    -2.902991e-03 -3.039188e-03 -3.181677e-03 -3.330740e-03
## ASV1613      2.198662e-03  2.298004e-03  2.401583e-03  2.509555e-03
## ASV0135     -2.849883e-04 -2.975856e-04 -3.106933e-04 -3.243279e-04
## ASV0469     -2.828905e-03 -2.957761e-03 -3.092217e-03 -3.232492e-03
## ASV0471      1.713601e-03  1.792611e-03  1.875143e-03  1.961342e-03
## ASV0451     -2.662465e-04 -2.801635e-04 -2.948544e-04 -3.103653e-04
## ASV0747      9.719342e-04  1.017125e-03  1.064365e-03  1.113742e-03
## ASV1314     -9.672557e-04 -1.013248e-03 -1.061423e-03 -1.111885e-03
## ASV0425     -3.519540e-03 -3.677859e-03 -3.842867e-03 -4.014805e-03
## ASV0559     -8.634527e-04 -9.030922e-04 -9.444871e-04 -9.877098e-04
## ASV0148     -2.047369e-04 -2.130927e-04 -2.217185e-04 -2.306155e-04
## ASV0129      1.830656e-04  1.935972e-04  2.047963e-04  2.167095e-04
## ASV1072      2.374195e-04  2.476678e-04  2.583066e-04  2.693455e-04
## ASV2390      1.811743e-03  1.892306e-03  1.976178e-03  2.063472e-03
## ASV0548      1.180051e-03  1.234357e-03  1.291074e-03  1.350300e-03
## ASV0168     -6.085954e-04 -6.362849e-04 -6.651742e-04 -6.953098e-04
## ASV0066     -6.841715e-04 -7.154692e-04 -7.481379e-04 -7.822320e-04
## ASV0468     -3.605111e-04 -3.772102e-04 -3.946614e-04 -4.128967e-04
## ASV0172     -2.102074e-04 -2.192395e-04 -2.286119e-04 -2.383328e-04
## ASV0236     -6.190475e-05 -6.207895e-05 -6.200914e-05 -6.166170e-05
## ASV0250      9.402565e-04  9.860456e-04  1.034107e-03  1.084557e-03
## ASV0338      4.508656e-04  4.722809e-04  4.947066e-04  5.181892e-04
## ASV0450     -8.003634e-05 -8.433259e-05 -8.887701e-05 -9.368514e-05
## ASV0377      8.554172e-04  8.944657e-04  9.352179e-04  9.777411e-04
## ASV1022     -3.714233e-05 -3.875676e-05 -4.043250e-05 -4.217088e-05
## ASV6174     -1.619628e-05 -1.721493e-05 -1.830641e-05 -1.947653e-05
## ASV0786     -1.086040e-04 -1.147699e-04 -1.213167e-04 -1.282697e-04
## ASV0053     -9.198777e-04 -9.624983e-04 -1.007038e-03 -1.053577e-03
## ASV0697     -5.653542e-04 -5.908739e-04 -6.174812e-04 -6.452165e-04
## ASV0785      1.184704e-03  1.238811e-03  1.295281e-03  1.354208e-03
## ASV1967     -1.179816e-03 -1.233380e-03 -1.289259e-03 -1.347541e-03
## ASV0385      3.889252e-04  4.075189e-04  4.270020e-04  4.474167e-04
## ASV0295      6.254959e-05  6.626518e-05  7.022506e-05  7.444681e-05
## ASV0072     -9.237262e-04 -9.655595e-04 -1.009185e-03 -1.054671e-03
## ASV0157     -1.277479e-04 -1.324133e-04 -1.371704e-04 -1.420119e-04
## ASV0501      1.984472e-03  2.076617e-03  2.172929e-03  2.273587e-03
## ASV10729    -2.489752e-03 -2.605853e-03 -2.727252e-03 -2.854180e-03
## ASV1470      1.295852e-03  1.353231e-03  1.412946e-03  1.475073e-03
## ASV0050     -2.165389e-03 -2.264470e-03 -2.367896e-03 -2.475838e-03
## ASV0411     -4.825363e-04 -5.053188e-04 -5.291671e-04 -5.541299e-04
## ASV0549      7.779374e-04  8.144037e-04  8.525515e-04  8.924557e-04
## ASV0184      2.626008e-04  2.746132e-04  2.871535e-04  3.002429e-04
## ASV0705      5.215760e-04  5.451950e-04  5.698259e-04  5.955065e-04
## ASV1715      1.093679e-03  1.144298e-03  1.197191e-03  1.252454e-03
## ASV0603      1.691494e-04  1.771201e-04  1.854640e-04  1.941983e-04
## ASV0826      1.852511e-03  1.937565e-03  2.026376e-03  2.119097e-03
## ASV0034     -5.962495e-04 -6.232988e-04 -6.515118e-04 -6.809330e-04
## ASV0838      4.335849e-04  4.507466e-04  4.684027e-04  4.865476e-04
## ASV0614     -5.074752e-04 -5.307430e-04 -5.550365e-04 -5.803970e-04
## ASV0014     -1.342886e-03 -1.404690e-03 -1.469238e-03 -1.536643e-03
## ASV0585      1.684096e-04  1.739525e-04  1.795346e-04  1.851381e-04
## ASV0016     -1.402849e-03 -1.467411e-03 -1.534840e-03 -1.605252e-03
## ASV5394     -1.047832e-03 -1.096496e-03 -1.147362e-03 -1.200524e-03
## ASV0666      2.313552e-03  2.417881e-03  2.526643e-03  2.640001e-03
## ASV2085      5.613863e-04  5.835360e-04  6.063252e-04  6.297485e-04
## ASV0003     -9.568439e-04 -1.000851e-03 -1.046810e-03 -1.094799e-03
## ASV0346      4.741897e-04  4.967637e-04  5.204092e-04  5.451765e-04
## ASV0267     -1.059339e-05 -1.035201e-05 -1.003071e-05 -9.619673e-06
## ASV0353      7.572388e-04  7.928966e-04  8.302139e-04  8.692660e-04
## ASV2419      2.064561e-03  2.158983e-03  2.257542e-03  2.360403e-03
## ASV0447      1.109100e-03  1.161455e-03  1.216258e-03  1.273619e-03
## ASV0654      1.660155e-03  1.736660e-03  1.816570e-03  1.900027e-03
## ASV0151      2.135466e-04  2.242580e-04  2.355293e-04  2.473914e-04
## ASV0065     -6.443480e-04 -6.738357e-04 -7.046169e-04 -7.367434e-04
## ASV0527      1.581939e-03  1.654597e-03  1.730468e-03  1.809683e-03
## ASV4055     -2.441545e-04 -2.560155e-04 -2.684642e-04 -2.815308e-04
## ASV0166     -8.008690e-04 -8.369838e-04 -8.746329e-04 -9.138726e-04
## ASV0417     -3.316611e-04 -3.461870e-04 -3.612888e-04 -3.769837e-04
## ASV0078     -4.735013e-04 -4.949708e-04 -5.173626e-04 -5.407116e-04
## ASV0322     -9.230446e-05 -9.589187e-05 -9.957224e-05 -1.033425e-04
## ASV0156     -1.113220e-03 -1.165119e-03 -1.219388e-03 -1.276128e-03
## ASV0648     -2.413559e-03 -2.526498e-03 -2.644627e-03 -2.768176e-03
## ASV0407     -1.795443e-04 -1.880989e-04 -1.970613e-04 -2.064508e-04
## ASV2030     -4.074045e-04 -4.258646e-04 -4.451250e-04 -4.652177e-04
## ASV0300      2.860143e-04  2.996251e-04  3.138822e-04  3.288160e-04
## ASV1150      6.237910e-05  6.555742e-05  6.890533e-05  7.243238e-05
## ASV0958      8.831735e-04  9.252564e-04  9.693446e-04  1.015534e-03
## ASV0216     -9.965344e-04 -1.041917e-03 -1.089274e-03 -1.138683e-03
## ASV0446      1.487161e-03  1.556779e-03  1.629596e-03  1.705756e-03
## ASV0367     -9.778624e-04 -1.023256e-03 -1.070702e-03 -1.120289e-03
## ASV0200     -5.819438e-04 -6.089316e-04 -6.371370e-04 -6.666116e-04
## ASV0334     -3.283776e-04 -3.422161e-04 -3.565520e-04 -3.713951e-04
## ASV1311      3.928323e-04  4.098947e-04  4.276192e-04  4.460239e-04
## ASV0458      5.829026e-04  6.079639e-04  6.339756e-04  6.609620e-04
## ASV1371      8.939484e-05  9.379673e-05  9.842015e-05  1.032765e-04
## ASV0418      1.314011e-03  1.373041e-03  1.434559e-03  1.498654e-03
## ASV0004      1.908115e-04  1.993495e-04  2.082439e-04  2.175073e-04
## ASV1943      3.730929e-03  3.889521e-03  4.053983e-03  4.224456e-03
## ASV1495     -2.413567e-04 -2.545741e-04 -2.685778e-04 -2.834188e-04
## ASV0901     -1.092509e-03 -1.143864e-03 -1.197603e-03 -1.253832e-03
## ASV0628      5.960594e-04  6.223815e-04  6.497675e-04  6.782512e-04
## ASV0400      3.590848e-04  3.753214e-04  3.922508e-04  4.098988e-04
## ASV0116     -3.214936e-04 -3.365822e-04 -3.523687e-04 -3.688845e-04
## ASV0788      2.839567e-03  2.973079e-03  3.112789e-03  3.258977e-03
## ASV0117      2.073420e-04  2.173024e-04  2.277444e-04  2.386915e-04
## ASV3137     -6.754449e-05 -7.060033e-05 -7.378692e-05 -7.710917e-05
## ASV0001      2.052085e-04  2.143551e-04  2.238802e-04  2.337965e-04
## ASV1651      5.830827e-04  6.092477e-04  6.365123e-04  6.649158e-04
## ASV1692      2.366140e-03  2.477254e-03  2.593513e-03  2.715147e-03
## ASV0660      8.688787e-04  9.069640e-04  9.465597e-04  9.877107e-04
## ASV0508      4.394209e-05  4.582801e-05  4.778523e-05  4.981558e-05
## ASV1660     -4.684930e-04 -4.914328e-04 -5.155186e-04 -5.408092e-04
## ASV0233      7.348983e-04  7.689496e-04  8.045350e-04  8.417193e-04
## ASV1343     -1.348796e-03 -1.411993e-03 -1.478102e-03 -1.547255e-03
## ASV0209      6.858836e-04  7.165013e-04  7.483899e-04  7.815934e-04
## ASV0193     -7.990652e-04 -8.349228e-04 -8.722863e-04 -9.112097e-04
## ASV0357      2.927810e-04  3.074391e-04  3.228615e-04  3.390909e-04
## ASV0198      6.027541e-04  6.302433e-04  6.589300e-04  6.888613e-04
## ASV0007      1.819501e-04  1.899741e-04  1.983218e-04  2.070034e-04
## ASV1772     -2.723227e-04 -2.841661e-04 -2.964667e-04 -3.092363e-04
## ASV0009      1.510364e-04  1.576202e-04  1.644622e-04  1.715696e-04
## ASV0006     -1.590210e-04 -1.666299e-04 -1.746041e-04 -1.829612e-04
## ASV0011     -5.569907e-04 -5.830085e-04 -6.102177e-04 -6.386707e-04
## ASV0015      1.141728e-04  1.191481e-04  1.243181e-04  1.296884e-04
## ASV0017      1.285820e-04  1.341892e-04  1.400166e-04  1.460703e-04
## ASV0235     -5.137226e-04 -5.378257e-04 -5.630419e-04 -5.894208e-04
## ASV0382      4.020712e-04  4.209504e-04  4.407006e-04  4.613601e-04
## ASV2357      1.678676e-03  1.757003e-03  1.838911e-03  1.924556e-03
## ASV0567     -3.243945e-04 -3.396134e-04 -3.555372e-04 -3.721978e-04
## ASV0165      2.800707e-04  2.931412e-04  3.068087e-04  3.210994e-04
## ASV0005      4.087447e-04  4.275475e-04  4.471839e-04  4.676880e-04
## ASV0384     -5.002432e-05 -5.170185e-05 -5.339445e-05 -5.509708e-05
## ASV0002      7.716036e-05  8.063210e-05  8.425085e-05  8.802205e-05
## ASV3017      2.185643e-03  2.283842e-03  2.386178e-03  2.492798e-03
## ASV0091     -5.517199e-05 -5.767397e-05 -6.028419e-05 -6.300695e-05
## ASV0186     -8.225741e-04 -8.605617e-04 -9.002474e-04 -9.417018e-04
## ASV0370      4.385145e-04  4.585141e-04  4.793839e-04  5.011579e-04
## ASV0018      5.231753e-04  5.472932e-04  5.724853e-04  5.987959e-04
## ASV1377      5.288253e-03  5.527202e-03  5.776347e-03  6.036069e-03
## ASV0019      5.487159e-04  5.740269e-04  6.004669e-04  6.280825e-04
## ASV0023     -3.404314e-04 -3.564278e-04 -3.731652e-04 -3.906771e-04
## ASV2194      5.455209e-04  5.713420e-04  5.983784e-04  6.266867e-04
## ASV1155      2.214893e-03  2.314647e-03  2.418641e-03  2.527036e-03
## ASV0510     -6.009473e-04 -6.272208e-04 -6.545295e-04 -6.829036e-04
## ASV2371     -1.333408e-03 -1.393514e-03 -1.456177e-03 -1.521494e-03
## ASV0024     -4.242841e-04 -4.441777e-04 -4.649890e-04 -4.867590e-04
## ASV2452      1.350354e-03  1.410053e-03  1.472172e-03  1.536789e-03
## ASV2332     -3.819618e-03 -3.992863e-03 -4.173579e-03 -4.362056e-03
## ASV2591      9.620410e-04  1.009988e-03  1.060392e-03  1.113382e-03
## ASV0521      8.623833e-04  9.027754e-04  9.450277e-04  9.892228e-04
## ASV5542      8.250147e-04  8.637387e-04  9.042476e-04  9.466201e-04
## ASV0336     -9.749057e-05 -1.027956e-04 -1.084121e-04 -1.143596e-04
## ASV10102     1.525551e-03  1.596985e-03  1.671703e-03  1.749851e-03
## ASV16823    -2.407717e-03 -2.514509e-03 -2.625684e-03 -2.741391e-03
## ASV3104      1.245643e-02  1.300885e-02  1.358393e-02  1.418245e-02
## ASV0781      1.713420e-03  1.792294e-03  1.874672e-03  1.960697e-03
## ASV10899     9.722549e-04  1.020770e-03  1.071789e-03  1.125448e-03
## ASV11222    -4.237051e-03 -4.424943e-03 -4.620543e-03 -4.824113e-03
## ASV11327    -3.803629e-03 -3.972279e-03 -4.147845e-03 -4.330562e-03
## ASV12458    -4.235951e-03 -4.423743e-03 -4.619236e-03 -4.822688e-03
## ASV1636      2.371612e-03  2.479217e-03  2.591453e-03  2.708497e-03
## ASV1890     -1.967807e-03 -2.052867e-03 -2.141212e-03 -2.232936e-03
## ASV2898      3.179191e-03  3.323503e-03  3.474036e-03  3.631028e-03
## ASV8328      3.179328e-04  3.385571e-04  3.606504e-04  3.843234e-04
## ASV0709     -3.530199e-03 -3.692012e-03 -3.860940e-03 -4.037269e-03
## ASV0856      2.890290e-03  3.027222e-03  3.170599e-03  3.320716e-03
## ASV0909      7.999937e-04  8.415500e-04  8.853960e-04  9.316672e-04
## ASV0937     -2.058277e-03 -2.154398e-03 -2.254926e-03 -2.360058e-03
## ASV11390    -6.044963e-03 -6.312926e-03 -6.591872e-03 -6.882175e-03
## ASV11966     1.405809e-03  1.473461e-03  1.544387e-03  1.618747e-03
## ASV12990     1.047243e-03  1.094579e-03  1.143930e-03  1.195370e-03
## ASV14797     1.556547e-03  1.626321e-03  1.699020e-03  1.774747e-03
## ASV14904    -8.674087e-03 -9.058582e-03 -9.458838e-03 -9.875387e-03
## ASV15304     8.700199e-04  9.130417e-04  9.582456e-04  1.005746e-03
## ASV16696    -2.996769e-03 -3.129594e-03 -3.267862e-03 -3.411758e-03
## ASV1690      4.906136e-03  5.139217e-03  5.383305e-03  5.638910e-03
## ASV2029      3.475145e-03  3.633898e-03  3.799593e-03  3.972504e-03
## ASV2834      4.318707e-03  4.519767e-03  4.729969e-03  4.949709e-03
## ASV4003      3.496143e-03  3.664352e-03  3.840720e-03  4.025646e-03
## ASV4064      2.044563e-03  2.140258e-03  2.240348e-03  2.345027e-03
## ASV4294      1.205090e-03  1.264559e-03  1.327041e-03  1.392694e-03
## ASV4609      1.176645e-03  1.230293e-03  1.286273e-03  1.344673e-03
## ASV6283     -2.801497e-03 -2.925678e-03 -3.054949e-03 -3.189482e-03
## ASV6491     -4.014896e-03 -4.192838e-03 -4.378072e-03 -4.570845e-03
## ASV7453      1.860893e-03  1.950802e-03  2.045095e-03  2.143986e-03
## ASV7959      6.467521e-04  6.802490e-04  7.155764e-04  7.528406e-04
## ASV8219      3.469500e-02  3.623261e-02  3.783322e-02  3.949897e-02
## ASV8547     -3.593847e-03 -3.753097e-03 -3.918870e-03 -4.091388e-03
## ASV9319      1.517603e-03  1.589331e-03  1.664419e-03  1.743021e-03
## ASV9382     -7.031309e-03 -7.342855e-03 -7.667162e-03 -8.004661e-03
## ASV11516    -4.695742e-03 -4.903775e-03 -5.120326e-03 -5.345683e-03
## ASV14377    -3.390140e-03 -3.540311e-03 -3.696630e-03 -3.859303e-03
## ASV1867      2.558458e-03  2.678143e-03  2.803324e-03  2.934242e-03
## ASV1895      1.320001e-03  1.378448e-03  1.439267e-03  1.502533e-03
## ASV3168      1.650956e-03  1.725039e-03  1.802227e-03  1.882628e-03
## ASV4449      8.988999e-03  9.401929e-03  9.833156e-03  1.028343e-02
## ASV6596      1.820662e-03  1.909103e-03  2.001909e-03  2.099300e-03
## ASV7492     -3.870592e-04 -4.003335e-04 -4.137844e-04 -4.273823e-04
## ASV9854     -7.288928e-04 -7.607877e-04 -7.939561e-04 -8.284384e-04
## ASV6296      5.687940e-02  5.939855e-02  6.202078e-02  6.474957e-02
## ASV4201      2.205078e-04  2.353922e-04  2.513745e-04  2.685396e-04
## ASV0552      1.772841e-03  1.855537e-03  1.942007e-03  2.032418e-03
## ASV3671     -1.195000e-03 -1.249385e-03 -1.306140e-03 -1.365361e-03
## ASV3529     -3.476708e-04 -3.599495e-04 -3.724409e-04 -3.851251e-04
## ASV1060      4.672447e-04  4.894485e-04  5.127058e-04  5.370666e-04
## ASV0239     -6.554325e-04 -6.842900e-04 -7.143081e-04 -7.455234e-04
## ASV5711     -2.926739e-03 -3.059465e-03 -3.197915e-03 -3.342312e-03
## ASV4152     -4.101666e-03 -4.291311e-03 -4.489469e-03 -4.696499e-03
## ASV1461      2.109961e-03  2.203359e-03  2.300557e-03  2.401681e-03
## ASV2877      1.091860e-03  1.140577e-03  1.191312e-03  1.244134e-03
## ASV0012      1.855416e-04  1.941008e-04  2.030422e-04  2.123817e-04
## ASV9823      2.786825e-04  2.901015e-04  3.018925e-04  3.140578e-04
## ASV0008      1.983381e-04  2.074468e-04  2.169586e-04  2.268898e-04
## ASV7832     -2.411152e-03 -2.522943e-03 -2.639787e-03 -2.761904e-03
## ASV1915     -3.112431e-04 -3.251314e-04 -3.396025e-04 -3.546781e-04
## ASV0055     -2.067851e-04 -2.169824e-04 -2.276965e-04 -2.389546e-04
## ASV0032      1.030459e-04  1.073836e-04  1.118765e-04  1.165275e-04
## ASV2977     -3.407138e-03 -3.564284e-03 -3.728447e-03 -3.899920e-03
## ASV0466      2.791067e-03  2.914667e-03  3.043305e-03  3.177148e-03
## ASV3866      1.855833e-03  1.942996e-03  2.034196e-03  2.129613e-03
## ASV0040      6.739644e-04  7.052703e-04  7.379936e-04  7.721952e-04
## ASV0496     -1.384547e-04 -1.469973e-04 -1.561223e-04 -1.658725e-04
## ASV0052      5.655633e-04  5.918618e-04  6.193535e-04  6.480895e-04
## ASV3828     -2.016496e-03 -2.105629e-03 -2.198392e-03 -2.294908e-03
## ASV1930      1.024065e-03  1.070342e-03  1.118589e-03  1.168881e-03
## ASV2126      1.735896e-03  1.815247e-03  1.898072e-03  1.984508e-03
## ASV0793      2.105201e-03  2.203804e-03  2.306947e-03  2.414830e-03
## ASV0299     -4.085428e-05 -4.280277e-05 -4.484760e-05 -4.699415e-05
## ASV0208      1.526417e-03  1.597287e-03  1.671363e-03  1.748784e-03
## ASV0511     -6.444724e-04 -6.728074e-04 -7.022751e-04 -7.329102e-04
## ASV1123     -1.945342e-03 -2.031273e-03 -2.120690e-03 -2.213706e-03
## ASV0099      5.454326e-05  5.731558e-05  6.023689e-05  6.331592e-05
## ASV0752     -1.073994e-03 -1.125097e-03 -1.178625e-03 -1.234691e-03
## ASV0883      1.475319e-03  1.545309e-03  1.618600e-03  1.695347e-03
## ASV0683      1.935179e-03  2.026342e-03  2.121750e-03  2.221594e-03
## ASV4117     -3.105951e-03 -3.249990e-03 -3.400537e-03 -3.557874e-03
## ASV2172      2.114583e-04  2.203191e-04  2.294904e-04  2.389769e-04
## ASV0330     -5.784997e-04 -6.055099e-04 -6.337562e-04 -6.632929e-04
## ASV0728      2.875613e-03  3.008213e-03  3.146720e-03  3.291377e-03
## ASV0499      7.521954e-04  7.877108e-04  8.248881e-04  8.638036e-04
## ASV0120     -1.274517e-03 -1.333373e-03 -1.394859e-03 -1.459085e-03
## ASV1446      1.019002e-03  1.062115e-03  1.106796e-03  1.153078e-03
## ASV17171    -2.466214e-03 -2.579648e-03 -2.698125e-03 -2.821854e-03
## ASV0533      1.787260e-04  1.874212e-04  1.965466e-04  2.061238e-04
## ASV2495     -5.813057e-04 -6.101909e-04 -6.405664e-04 -6.725138e-04
## ASV5582      1.174721e-03  1.225477e-03  1.278180e-03  1.332880e-03
## ASV1488      4.400826e-04  4.599107e-04  4.805778e-04  5.021141e-04
## ASV0682      5.469423e-04  5.728738e-04  6.000280e-04  6.284618e-04
## ASV0068     -9.637936e-04 -1.008437e-03 -1.055089e-03 -1.103834e-03
## ASV1987     -2.365401e-03 -2.478201e-03 -2.596377e-03 -2.720182e-03
## ASV0035     -1.640661e-04 -1.729848e-04 -1.824309e-04 -1.924386e-04
## ASV7192     -1.506381e-03 -1.574824e-03 -1.646227e-03 -1.720705e-03
## ASV0873      9.630001e-05  7.496700e-05  5.036257e-05  2.214805e-05
## ASV4749     -3.592283e-06 -8.027645e-06 -1.306088e-05 -1.875403e-05
## ASV2174      1.068559e-03  1.115134e-03  1.163533e-03  1.213810e-03
## ASV1476     -1.052884e-03 -1.102660e-03 -1.154776e-03 -1.209340e-03
## ASV0740     -2.991006e-03 -3.132328e-03 -3.280272e-03 -3.435143e-03
## ASV0170     -5.909987e-04 -6.183886e-04 -6.470128e-04 -6.769237e-04
## ASV2466     -2.694505e-03 -2.819352e-03 -2.949828e-03 -3.086175e-03
## ASV1709      1.002623e-03  1.047655e-03  1.094597e-03  1.143522e-03
## ASV6170     -4.194210e-03 -4.390916e-03 -4.596705e-03 -4.811984e-03
## ASV3673      2.052426e-03  2.149376e-03  2.250866e-03  2.357106e-03
## ASV1745     -5.246229e-04 -5.500613e-04 -5.767512e-04 -6.047554e-04
##                                                                    
## (Intercept)  1.720319e-02  1.799690e-02  1.882599e-02  1.969190e-02
## ASV1236      3.426164e-03  3.579656e-03  3.739587e-03  3.906188e-03
## ASV0421      3.730031e-04  3.927303e-04  4.135694e-04  4.355873e-04
## ASV0691     -2.702747e-03 -2.817791e-03 -2.937098e-03 -3.060771e-03
## ASV0899      2.965725e-03  3.099201e-03  3.238317e-03  3.383277e-03
## ASV1004      6.854603e-03  7.162598e-03  7.483580e-03  7.818021e-03
## ASV1041     -2.821659e-03 -2.948023e-03 -3.079663e-03 -3.216763e-03
## ASV1058      4.279906e-03  4.471928e-03  4.672026e-03  4.880491e-03
## ASV12542     1.666718e-03  1.740293e-03  1.816850e-03  1.896488e-03
## ASV1294      3.981898e-03  4.160752e-03  4.347146e-03  4.541353e-03
## ASV13113     1.308245e-03  1.370805e-03  1.436364e-03  1.505069e-03
## ASV1318      3.971251e-03  4.149525e-03  4.335303e-03  4.528855e-03
## ASV2269     -6.880564e-03 -7.188759e-03 -7.509852e-03 -7.844303e-03
## ASV2542      3.317226e-03  3.471953e-03  3.633749e-03  3.802922e-03
## ASV2660     -2.741035e-03 -2.863301e-03 -2.990640e-03 -3.123226e-03
## ASV2737      9.563808e-04  9.977704e-04  1.040762e-03  1.085402e-03
## ASV2840      3.670459e-03  3.831459e-03  3.998875e-03  4.172904e-03
## ASV3053      1.874767e-02  1.957683e-02  2.043975e-02  2.133755e-02
## ASV3077      1.194854e-03  1.247845e-03  1.303010e-03  1.360422e-03
## ASV3134      2.094888e-03  2.193960e-03  2.297683e-03  2.406274e-03
## ASV3140      2.860545e-03  2.992279e-03  3.129869e-03  3.273557e-03
## ASV3579      9.978414e-04  1.046570e-03  1.097724e-03  1.151428e-03
## ASV6119     -1.882886e-03 -1.967210e-03 -2.055063e-03 -2.146568e-03
## ASV7557     -3.825867e-03 -3.997179e-03 -4.175655e-03 -4.361551e-03
## ASV8422      9.564451e-04  9.987944e-04  1.042874e-03  1.088742e-03
## ASV1086     -1.516885e-04 -1.579786e-04 -1.644871e-04 -1.712179e-04
## ASV1310      1.832633e-03  1.914821e-03  2.000458e-03  2.089669e-03
## ASV15750    -2.520979e-04 -2.629313e-04 -2.741739e-04 -2.858360e-04
## ASV16905    -7.867266e-04 -8.219538e-04 -8.586544e-04 -8.968805e-04
## ASV2033      3.324060e-03  3.480303e-03  3.643784e-03  3.814828e-03
## ASV2089      1.658638e-03  1.732964e-03  1.810404e-03  1.891068e-03
## ASV2127      5.386268e-03  5.627815e-03  5.879505e-03  6.141704e-03
## ASV2725      4.320407e-03  4.512070e-03  4.711588e-03  4.919225e-03
## ASV2804     -1.628508e-03 -1.701422e-03 -1.777385e-03 -1.856505e-03
## ASV3075      3.553582e-03  3.716093e-03  3.885744e-03  4.062822e-03
## ASV3327      4.895104e-03  5.122974e-03  5.361204e-03  5.610242e-03
## ASV3342      4.211710e-03  4.406830e-03  4.610737e-03  4.823807e-03
## ASV3532     -4.655711e-03 -4.869637e-03 -5.093040e-03 -5.326310e-03
## ASV3600      2.162439e-03  2.262131e-03  2.366270e-03  2.475041e-03
## ASV4013      4.047293e-03  4.231062e-03  4.422760e-03  4.622694e-03
## ASV4136      4.336042e-03  4.528712e-03  4.729317e-03  4.938131e-03
## ASV4195      1.662154e-02  1.736560e-02  1.814077e-02  1.894814e-02
## ASV4407     -6.421286e-03 -6.708687e-03 -7.008098e-03 -7.319942e-03
## ASV4717      1.127424e-03  1.175821e-03  1.226053e-03  1.278167e-03
## ASV6794      2.671590e-03  2.788935e-03  2.910987e-03  3.037899e-03
## ASV8324     -3.294920e-03 -3.442394e-03 -3.596030e-03 -3.756047e-03
## ASV8981     -8.780462e-05 -9.039810e-05 -9.297171e-05 -9.551213e-05
## ASV9859      1.119030e-03  1.174319e-03  1.232422e-03  1.293489e-03
## ASV0936      3.174699e-03  3.321945e-03  3.475831e-03  3.636639e-03
## ASV12683    -1.530964e-06 -2.058284e-06 -2.648774e-06 -3.308256e-06
## ASV1293      2.138061e-03  2.233612e-03  2.333143e-03  2.436797e-03
## ASV13055    -5.493672e-05 -5.641697e-05 -5.786518e-05 -5.927098e-05
## ASV17063    -1.708907e-03 -1.785348e-03 -1.864979e-03 -1.947913e-03
## ASV2228      1.393483e-03  1.455805e-03  1.520727e-03  1.588340e-03
## ASV2769      2.126197e-04  2.236413e-04  2.352644e-04  2.475237e-04
## ASV2803      1.515147e-03  1.581308e-03  1.650081e-03  1.721547e-03
## ASV2896      1.196168e-03  1.251948e-03  1.310280e-03  1.371276e-03
## ASV3062      1.434149e-03  1.503296e-03  1.575806e-03  1.651845e-03
## ASV3107      2.232017e-03  2.335493e-03  2.443638e-03  2.556653e-03
## ASV3265      3.060047e-03  3.196567e-03  3.338750e-03  3.486795e-03
## ASV3666      3.032024e-05  3.152353e-05  3.276074e-05  3.403128e-05
## ASV4497      1.049425e-03  1.096677e-03  1.145930e-03  1.197260e-03
## ASV6914     -1.531228e-04 -1.609158e-04 -1.691242e-04 -1.777715e-04
## ASV0576     -3.671381e-03 -3.830711e-03 -3.996243e-03 -4.168155e-03
## ASV0673      4.037447e-03  4.220278e-03  4.410951e-03  4.609762e-03
## ASV0772      1.872059e-03  1.957304e-03  2.046252e-03  2.139050e-03
## ASV0862      1.646219e-04  1.759051e-04  1.880290e-04  2.010586e-04
## ASV0898      1.443940e-03  1.512176e-03  1.583605e-03  1.658372e-03
## ASV0910      1.671690e-03  1.749511e-03  1.830873e-03  1.915929e-03
## ASV0964     -1.385623e-03 -1.446348e-03 -1.509490e-03 -1.575123e-03
## ASV10059     1.184080e-03  1.240518e-03  1.299644e-03  1.361585e-03
## ASV10263    -2.603180e-03 -2.719733e-03 -2.841161e-03 -2.967637e-03
## ASV1088      2.984758e-03  3.122719e-03  3.266876e-03  3.417492e-03
## ASV1101      3.723060e-03  3.889391e-03  4.062642e-03  4.243058e-03
## ASV1183      9.794470e-04  1.024440e-03  1.071425e-03  1.120482e-03
## ASV11956     9.586255e-04  1.000097e-03  1.043171e-03  1.087892e-03
## ASV12774     5.981671e-05  6.134744e-05  6.283281e-05  6.426064e-05
## ASV1321      4.311281e-03  4.513142e-03  4.724291e-03  4.945143e-03
## ASV13793    -1.794822e-03 -1.875176e-03 -1.958890e-03 -2.046083e-03
## ASV14482     1.161266e-04  1.208892e-04  1.258140e-04  1.309039e-04
## ASV15483     7.333233e-04  7.674007e-04  8.030217e-04  8.402524e-04
## ASV2062      3.433574e-03  3.589192e-03  3.751503e-03  3.920764e-03
## ASV2132      2.791602e-03  2.921037e-03  3.056309e-03  3.197666e-03
## ASV2413      2.659682e-03  2.779027e-03  2.903396e-03  3.032969e-03
## ASV2490      8.212671e-03  8.575112e-03  8.952236e-03  9.344520e-03
## ASV2594      1.018910e-03  1.065764e-03  1.114703e-03  1.165814e-03
## ASV2822     -4.736810e-03 -4.948955e-03 -5.169979e-03 -5.400196e-03
## ASV2863      5.046810e-03  5.271129e-03  5.504693e-03  5.747819e-03
## ASV2910      1.844816e-03  1.927293e-03  2.013210e-03  2.102689e-03
## ASV2980      2.052514e-03  2.145749e-03  2.243011e-03  2.344456e-03
## ASV3307      3.768500e-03  3.937222e-03  4.113000e-03  4.296084e-03
## ASV3474      2.465189e-03  2.581457e-03  2.703150e-03  2.830516e-03
## ASV3502      2.603780e-03  2.723093e-03  2.847660e-03  2.977691e-03
## ASV4236      3.864361e-03  4.034184e-03  4.210809e-03  4.394450e-03
## ASV4842     -4.097462e-04 -4.291011e-04 -4.493504e-04 -4.705326e-04
## ASV4894     -1.795248e-03 -1.875644e-03 -1.959405e-03 -2.046649e-03
## ASV5290      1.417311e-03  1.482861e-03  1.551351e-03  1.622904e-03
## ASV5501      8.681759e-04  9.079297e-04  9.494367e-04  9.927691e-04
## ASV5795      9.519715e-04  9.960971e-04  1.042211e-03  1.090398e-03
## ASV5987     -5.014588e-03 -5.239191e-03 -5.473196e-03 -5.716938e-03
## ASV6267     -5.649893e-03 -5.902910e-03 -6.166514e-03 -6.441082e-03
## ASV6862      2.274179e-03  2.374606e-03  2.479111e-03  2.587827e-03
## ASV7145      1.006634e-03  1.050494e-03  1.096086e-03  1.143465e-03
## ASV7673     -1.795145e-03 -1.875533e-03 -1.959285e-03 -2.046520e-03
## ASV7789      8.731904e-04  9.160554e-04  9.610752e-04  1.008362e-03
## ASV7809      5.415450e-05  5.802490e-05  6.219331e-05  6.668331e-05
## ASV8002     -2.267160e-03 -2.368684e-03 -2.474455e-03 -2.584626e-03
## ASV8205      9.439263e-04  9.874446e-04  1.032904e-03  1.080386e-03
## ASV9155     -5.782269e-04 -6.037185e-04 -6.302384e-04 -6.578194e-04
## ASV9221      2.214090e-04  2.338617e-04  2.470782e-04  2.611091e-04
## ASV9311     -3.636777e-03 -3.799618e-03 -3.969273e-03 -4.145982e-03
## ASV9557     -2.485226e-03 -2.596486e-03 -2.712401e-03 -2.833133e-03
## ASV9936     -5.011316e-03 -5.235629e-03 -5.469321e-03 -5.712724e-03
## ASV1445      3.025937e-03  3.165556e-03  3.311409e-03  3.463756e-03
## ASV4232      1.136868e-03  1.191040e-03  1.247797e-03  1.307262e-03
## ASV6479      3.937041e-04  4.149407e-04  4.374089e-04  4.611857e-04
## ASV0142     -2.162811e-03 -2.259124e-03 -2.359419e-03 -2.463834e-03
## ASV0378      9.683101e-04  1.014485e-03  1.062860e-03  1.113541e-03
## ASV1122      2.925589e-03  3.061247e-03  3.203025e-03  3.351183e-03
## ASV0123     -1.910498e-03 -1.995456e-03 -2.083915e-03 -2.175995e-03
## ASV2064      9.840587e-04  1.026476e-03  1.070512e-03  1.116207e-03
## ASV4459     -1.397000e-04 -1.453126e-04 -1.511021e-04 -1.570699e-04
## ASV0448      7.741139e-04  8.110691e-04  8.497886e-04  8.903562e-04
## ASV0397      1.726099e-03  1.804868e-03  1.887074e-03  1.972853e-03
## ASV0485      2.010354e-03  2.101209e-03  2.195949e-03  2.294720e-03
## ASV1566      2.956510e-03  3.091168e-03  3.231674e-03  3.378259e-03
## ASV1365      2.519896e-03  2.635683e-03  2.756590e-03  2.882826e-03
## ASV1065      3.582684e-03  3.746990e-03  3.918541e-03  4.097629e-03
## ASV0722     -1.858321e-04 -1.945906e-04 -2.037592e-04 -2.133568e-04
## ASV12660    -2.072058e-03 -2.163881e-03 -2.259465e-03 -2.358937e-03
## ASV0223      5.549855e-04  5.801401e-04  6.063782e-04  6.337414e-04
## ASV0229      8.422298e-04  8.813413e-04  9.222242e-04  9.649548e-04
## ASV0877      3.599801e-04  3.753919e-04  3.913746e-04  4.079404e-04
## ASV0983      1.997296e-03  2.087203e-03  2.180918e-03  2.278579e-03
## ASV0626      2.024770e-04  2.141946e-04  2.266505e-04  2.398943e-04
## ASV4146      9.839500e-05  1.028138e-04  1.074116e-04  1.121930e-04
## ASV4175     -2.446249e-03 -2.559456e-03 -2.677748e-03 -2.801340e-03
## ASV2082     -1.077008e-03 -1.131594e-03 -1.189077e-03 -1.249623e-03
## ASV2272      1.165928e-03  1.219659e-03  1.275787e-03  1.334412e-03
## ASV2245     -1.745372e-03 -1.826483e-03 -1.911267e-03 -1.999881e-03
## ASV0590     -1.008588e-03 -1.061142e-03 -1.116601e-03 -1.175137e-03
## ASV0217      7.353255e-05  8.040041e-05  8.789258e-05  9.606343e-05
## ASV0416      1.351042e-03  1.408781e-03  1.468676e-03  1.530781e-03
## ASV1056      1.683435e-03  1.762530e-03  1.845285e-03  1.931866e-03
## ASV7777     -2.383326e-03 -2.493131e-03 -2.607827e-03 -2.727620e-03
## ASV0455      4.283245e-04  4.479448e-04  4.684275e-04  4.898073e-04
## ASV0604      1.105778e-03  1.158222e-03  1.213138e-03  1.270640e-03
## ASV6100     -1.638585e-03 -1.714798e-03 -1.794474e-03 -1.877763e-03
## ASV11359    -3.530042e-03 -3.692749e-03 -3.862703e-03 -4.040204e-03
## ASV6604      4.867140e-04  5.097110e-04  5.337844e-04  5.589832e-04
## ASV5004     -1.257335e-03 -1.314939e-03 -1.375080e-03 -1.437861e-03
## ASV1483     -5.422297e-04 -5.669482e-04 -5.927426e-04 -6.196552e-04
## ASV9773     -1.588655e-03 -1.662168e-03 -1.738986e-03 -1.819247e-03
## ASV4059     -9.725853e-06 -7.534930e-06 -5.003258e-06 -2.094691e-06
## ASV1193      1.925185e-03  2.013133e-03  2.104927e-03  2.200718e-03
## ASV4610     -3.213146e-04 -3.323119e-04 -3.434612e-04 -3.547400e-04
## ASV0742     -1.975805e-04 -2.035769e-04 -2.095577e-04 -2.154974e-04
## ASV1502     -7.735354e-05 -8.280788e-05 -8.867875e-05 -9.499901e-05
## ASV0195      5.227729e-05  5.349191e-05  5.465339e-05  5.575018e-05
## ASV1213      1.370955e-03  1.430631e-03  1.492647e-03  1.557070e-03
## ASV1648     -1.472165e-03 -1.540532e-03 -1.611998e-03 -1.686696e-03
## ASV6984     -1.377144e-03 -1.441146e-03 -1.508055e-03 -1.577996e-03
## ASV0396     -8.458421e-05 -8.714094e-05 -8.969199e-05 -9.222692e-05
## ASV4297      1.982542e-03  2.070069e-03  2.161141e-03  2.255874e-03
## ASV2622      3.064725e-03  3.202171e-03  3.345392e-03  3.494597e-03
## ASV3512      1.169175e-03  1.226601e-03  1.286918e-03  1.350279e-03
## ASV2411      2.065973e-03  2.163257e-03  2.265067e-03  2.371608e-03
## ASV2291     -8.686888e-04 -9.146074e-04 -9.631140e-04 -1.014365e-03
## ASV0807      2.835202e-03  2.964786e-03  3.100040e-03  3.241191e-03
## ASV1292      6.944801e-04  7.241525e-04  7.549351e-04  7.868550e-04
## ASV1035      2.614751e-03  2.731135e-03  2.852337e-03  2.978524e-03
## ASV0070      1.655229e-05  1.856565e-05  2.078545e-05  2.323103e-05
## ASV0255      2.496428e-04  2.603637e-04  2.714879e-04  2.830251e-04
## ASV0057     -7.226226e-04 -7.541203e-04 -7.868547e-04 -8.208620e-04
## ASV0077     -1.555001e-04 -1.618057e-04 -1.683128e-04 -1.750225e-04
## ASV0625      1.507538e-03  1.574240e-03  1.643660e-03  1.715886e-03
## ASV2464      1.026588e-02  1.071825e-02  1.118893e-02  1.167851e-02
## ASV1315      2.689469e-03  2.816608e-03  2.949707e-03  3.089040e-03
## ASV2673      2.306382e-03  2.415539e-03  2.529823e-03  2.649473e-03
## ASV2161      9.759162e-04  1.021976e-03  1.070191e-03  1.120659e-03
## ASV0337     -5.608067e-04 -5.868155e-04 -6.139975e-04 -6.424027e-04
## ASV7680     -3.658229e-03 -3.828289e-03 -4.006060e-03 -4.191877e-03
## ASV0611      2.042657e-03  2.137723e-03  2.237113e-03  2.341015e-03
## ASV3118     -2.112043e-03 -2.212412e-03 -2.317532e-03 -2.427625e-03
## ASV1284      7.956684e-04  8.238025e-04  8.524008e-04  8.814105e-04
## ASV0889      1.554707e-03  1.624770e-03  1.697813e-03  1.773945e-03
## ASV4649     -7.760353e-04 -8.117056e-04 -8.489569e-04 -8.878544e-04
## ASV1108     -1.576803e-03 -1.652529e-03 -1.731915e-03 -1.815139e-03
## ASV0738      8.633344e-04  9.066801e-04  9.522886e-04  1.000284e-03
## ASV0473     -1.721151e-04 -1.815481e-04 -1.915342e-04 -2.021077e-04
## ASV0598     -4.382667e-04 -4.609546e-04 -4.848873e-04 -5.101385e-04
## ASV0429      1.156467e-03  1.207961e-03  1.261579e-03  1.317394e-03
## ASV1549      2.127574e-03  2.228386e-03  2.333945e-03  2.444473e-03
## ASV1203      1.689715e-03  1.766131e-03  1.845815e-03  1.928892e-03
## ASV4532      7.497795e-05  7.778960e-05  8.067078e-05  8.361984e-05
## ASV0274      2.900996e-04  3.043225e-04  3.192553e-04  3.349340e-04
## ASV0163     -1.310565e-03 -1.368360e-03 -1.428495e-03 -1.491044e-03
## ASV1298      1.455109e-04  1.513711e-04  1.574205e-04  1.636613e-04
## ASV9424     -2.833992e-03 -2.966233e-03 -3.104523e-03 -3.249125e-03
## ASV0412      2.934090e-03  3.066089e-03  3.203676e-03  3.347056e-03
## ASV0284      6.206424e-04  6.466432e-04  6.735639e-04  7.014211e-04
## ASV0620     -5.904321e-04 -6.201065e-04 -6.513303e-04 -6.841884e-04
## ASV0153     -2.844593e-03 -2.979356e-03 -3.120461e-03 -3.268200e-03
## ASV0498      1.006686e-03  1.053547e-03  1.102536e-03  1.153741e-03
## ASV0097      5.588594e-04  5.853221e-04  6.130301e-04  6.420409e-04
## ASV0104     -3.975923e-03 -4.156967e-03 -4.345870e-03 -4.542937e-03
## ASV1282      1.376833e-03  1.437931e-03  1.501529e-03  1.567708e-03
## ASV3883     -1.078590e-03 -1.131184e-03 -1.186383e-03 -1.244321e-03
## ASV0801      5.370270e-04  5.619928e-04  5.880896e-04  6.153658e-04
## ASV1611     -2.537565e-03 -2.656861e-03 -2.781691e-03 -2.912305e-03
## ASV0227     -4.507816e-04 -4.741099e-04 -4.987109e-04 -5.246583e-04
## ASV0833      8.649037e-04  9.049780e-04  9.468552e-04  9.906114e-04
## ASV0718      3.871633e-03  4.050346e-03  4.237050e-03  4.432081e-03
## ASV1139      5.108085e-04  5.310395e-04  5.518641e-04  5.732788e-04
## ASV0766     -5.360902e-04 -5.623050e-04 -5.898241e-04 -6.187134e-04
## ASV2091      3.165449e-03  3.305641e-03  3.451554e-03  3.603377e-03
## ASV1238     -2.873493e-03 -3.007756e-03 -3.148183e-03 -3.295047e-03
## ASV9193     -2.666026e-04 -2.817393e-04 -2.978180e-04 -3.149028e-04
## ASV0290      4.173771e-04  4.345763e-04  4.523587e-04  4.707325e-04
## ASV0231      1.155016e-03  1.206973e-03  1.261127e-03  1.317559e-03
## ASV0185      6.628139e-04  6.959774e-04  7.308627e-04  7.675638e-04
## ASV2330      1.329236e-03  1.387391e-03  1.447851e-03  1.510687e-03
## ASV3119     -6.007029e-04 -6.306045e-04 -6.620440e-04 -6.951043e-04
## ASV2368     -1.471331e-03 -1.541152e-03 -1.614278e-03 -1.690862e-03
## ASV0122     -7.170754e-04 -7.495736e-04 -7.834693e-04 -8.188160e-04
## ASV1044      1.828213e-03  1.914189e-03  2.004156e-03  2.098294e-03
## ASV0160     -7.736069e-04 -8.075092e-04 -8.427619e-04 -8.794067e-04
## ASV0326      2.027411e-04  2.121559e-04  2.219953e-04  2.322772e-04
## ASV1388      3.718197e-03  3.887237e-03  4.063589e-03  4.247537e-03
## ASV0792      2.766173e-03  2.889745e-03  3.018460e-03  3.152500e-03
## ASV0036     -8.532234e-04 -8.936744e-04 -9.360303e-04 -9.803792e-04
## ASV2125      2.656042e-03  2.777378e-03  2.904019e-03  3.036174e-03
## ASV1075     -3.998165e-05 -4.180332e-05 -4.370605e-05 -4.569345e-05
## ASV0390      1.409172e-03  1.475928e-03  1.545830e-03  1.619024e-03
## ASV3790     -2.007340e-03 -2.100569e-03 -2.198019e-03 -2.299871e-03
## ASV1535     -5.730802e-04 -6.014295e-04 -6.312218e-04 -6.625335e-04
## ASV0263      2.462333e-03  2.575551e-03  2.693789e-03  2.817252e-03
## ASV0675      3.690316e-03  3.862881e-03  4.043367e-03  4.232124e-03
## ASV3348      2.972479e-04  3.116967e-04  3.268579e-04  3.427673e-04
## ASV0058     -1.100115e-03 -1.150012e-03 -1.202056e-03 -1.256330e-03
## ASV4142      1.547325e-03  1.616319e-03  1.688167e-03  1.762967e-03
## ASV0059     -8.869183e-04 -9.269352e-04 -9.686548e-04 -1.012140e-03
## ASV0013     -1.572352e-03 -1.644545e-03 -1.719929e-03 -1.798633e-03
## ASV0033     -7.419982e-04 -7.770808e-04 -8.138072e-04 -8.522529e-04
## ASV4354     -9.260692e-04 -9.686239e-04 -1.013069e-03 -1.059482e-03
## ASV0022     -6.266724e-04 -6.562776e-04 -6.872682e-04 -7.197076e-04
## ASV0134     -5.935963e-04 -6.223453e-04 -6.525040e-04 -6.841426e-04
## ASV0415      9.373821e-05  9.875516e-05  1.040566e-04  1.096593e-04
## ASV10103    -3.486671e-03 -3.649775e-03 -3.820371e-03 -3.998790e-03
## ASV1613      2.622082e-03  2.739327e-03  2.861461e-03  2.988653e-03
## ASV0135     -3.385057e-04 -3.532435e-04 -3.685577e-04 -3.844650e-04
## ASV0469     -3.378811e-03 -3.531408e-03 -3.690520e-03 -3.856393e-03
## ASV0471      2.051359e-03  2.145350e-03  2.243476e-03  2.345905e-03
## ASV0451     -3.267455e-04 -3.440474e-04 -3.623266e-04 -3.816424e-04
## ASV0747      1.165347e-03  1.219275e-03  1.275624e-03  1.334496e-03
## ASV1314     -1.164741e-03 -1.220105e-03 -1.278095e-03 -1.338836e-03
## ASV0425     -4.193923e-03 -4.380474e-03 -4.574716e-03 -4.776912e-03
## ASV0559     -1.032835e-03 -1.079941e-03 -1.129107e-03 -1.180418e-03
## ASV0148     -2.397847e-04 -2.492254e-04 -2.589363e-04 -2.689146e-04
## ASV0129      2.293866e-04  2.428810e-04  2.572503e-04  2.725561e-04
## ASV1072      2.807942e-04  2.926618e-04  3.049572e-04  3.176886e-04
## ASV2390      2.154297e-03  2.248768e-03  2.346997e-03  2.449100e-03
## ASV0548      1.412138e-03  1.476693e-03  1.544075e-03  1.614395e-03
## ASV0168     -7.267395e-04 -7.595127e-04 -7.936799e-04 -8.292928e-04
## ASV0066     -8.178077e-04 -8.549226e-04 -8.936362e-04 -9.340095e-04
## ASV0468     -4.319493e-04 -4.518535e-04 -4.726450e-04 -4.943608e-04
## ASV0172     -2.484102e-04 -2.588516e-04 -2.696643e-04 -2.808551e-04
## ASV0236     -6.099964e-05 -5.998228e-05 -5.856498e-05 -5.669882e-05
## ASV0250      1.137517e-03  1.193117e-03  1.251491e-03  1.312784e-03
## ASV0338      5.427774e-04  5.685217e-04  5.954750e-04  6.236923e-04
## ASV0450     -9.877359e-05 -1.041600e-04 -1.098634e-04 -1.159037e-04
## ASV0377      1.022104e-03  1.068379e-03  1.116638e-03  1.166956e-03
## ASV1022     -4.397314e-05 -4.584040e-05 -4.777362e-05 -4.977361e-05
## ASV6174     -2.073165e-05 -2.207863e-05 -2.352495e-05 -2.507874e-05
## ASV0786     -1.356559e-04 -1.435043e-04 -1.518457e-04 -1.607129e-04
## ASV0053     -1.102201e-03 -1.152996e-03 -1.206054e-03 -1.261466e-03
## ASV0697     -6.741216e-04 -7.042391e-04 -7.356124e-04 -7.682863e-04
## ASV0785      1.415687e-03  1.479818e-03  1.546703e-03  1.616445e-03
## ASV1967     -1.408318e-03 -1.471687e-03 -1.537743e-03 -1.606588e-03
## ASV0385      4.688073e-04  4.912200e-04  5.147032e-04  5.393074e-04
## ASV0295      7.894928e-05  8.375279e-05  8.887917e-05  9.435186e-05
## ASV0072     -1.102086e-03 -1.151500e-03 -1.202986e-03 -1.256618e-03
## ASV0157     -1.469292e-04 -1.519123e-04 -1.569495e-04 -1.620274e-04
## ASV0501      2.378775e-03  2.488686e-03  2.603518e-03  2.723476e-03
## ASV10729    -2.986878e-03 -3.125596e-03 -3.270592e-03 -3.422136e-03
## ASV1470      1.539689e-03  1.606872e-03  1.676699e-03  1.749249e-03
## ASV0050     -2.588477e-03 -2.705994e-03 -2.828580e-03 -2.956429e-03
## ASV0411     -5.802582e-04 -6.076053e-04 -6.362267e-04 -6.661803e-04
## ASV0549      9.341944e-04  9.778488e-04  1.023503e-03  1.071246e-03
## ASV0184      3.139036e-04  3.281584e-04  3.430308e-04  3.585452e-04
## ASV0705      6.222757e-04  6.501734e-04  6.792403e-04  7.095178e-04
## ASV1715      1.310187e-03  1.370491e-03  1.433474e-03  1.499246e-03
## ASV0603      2.033412e-04  2.129118e-04  2.229300e-04  2.334169e-04
## ASV0826      2.215887e-03  2.316909e-03  2.422329e-03  2.532322e-03
## ASV0034     -7.116076e-04 -7.435823e-04 -7.769047e-04 -8.116235e-04
## ASV0838      5.051730e-04  5.242675e-04  5.438163e-04  5.638009e-04
## ASV0614     -6.068677e-04 -6.344926e-04 -6.633174e-04 -6.933893e-04
## ASV0014     -1.607020e-03 -1.680491e-03 -1.757179e-03 -1.837213e-03
## ASV0585      1.907431e-04  1.963266e-04  2.018632e-04  2.073240e-04
## ASV0016     -1.678770e-03 -1.755518e-03 -1.835628e-03 -1.919232e-03
## ASV5394     -1.256080e-03 -1.314131e-03 -1.374784e-03 -1.438146e-03
## ASV0666      2.758123e-03  2.881180e-03  3.009347e-03  3.142802e-03
## ASV2085      6.537970e-04  6.784586e-04  7.037172e-04  7.295523e-04
## ASV0003     -1.144902e-03 -1.197204e-03 -1.251792e-03 -1.308758e-03
## ASV0346      5.711180e-04  5.982886e-04  6.267457e-04  6.565491e-04
## ASV0267     -9.108116e-06 -8.484224e-06 -7.735062e-06 -6.846488e-06
## ASV0353      9.101314e-04  9.528922e-04  9.976336e-04  1.044445e-03
## ASV2419      2.467736e-03  2.579716e-03  2.696525e-03  2.818347e-03
## ASV0447      1.333656e-03  1.396491e-03  1.462249e-03  1.531064e-03
## ASV0654      1.987175e-03  2.078164e-03  2.173150e-03  2.272293e-03
## ASV0151      2.598772e-04  2.730215e-04  2.868612e-04  3.014355e-04
## ASV0065     -7.702684e-04 -8.052468e-04 -8.417351e-04 -8.797915e-04
## ASV0527      1.892376e-03  1.978688e-03  2.068761e-03  2.162745e-03
## ASV4055     -2.952473e-04 -3.096473e-04 -3.247664e-04 -3.406419e-04
## ASV0166     -9.547609e-04 -9.973570e-04 -1.041721e-03 -1.087915e-03
## ASV0417     -3.932889e-04 -4.102215e-04 -4.277984e-04 -4.460365e-04
## ASV0078     -5.650534e-04 -5.904247e-04 -6.168630e-04 -6.444064e-04
## ASV0322     -1.071989e-04 -1.111364e-04 -1.151493e-04 -1.192303e-04
## ASV0156     -1.335449e-03 -1.397461e-03 -1.462282e-03 -1.530032e-03
## ASV0648     -2.897385e-03 -3.032502e-03 -3.173786e-03 -3.321506e-03
## ASV0407     -2.162878e-04 -2.265937e-04 -2.373909e-04 -2.487026e-04
## ASV2030     -4.861761e-04 -5.080348e-04 -5.308295e-04 -5.545974e-04
## ASV0300      3.444583e-04  3.608424e-04  3.780032e-04  3.959771e-04
## ASV1150      7.614872e-05  8.006505e-05  8.419273e-05  8.854377e-05
## ASV0958      1.063924e-03  1.114620e-03  1.167731e-03  1.223372e-03
## ASV0216     -1.190223e-03 -1.243978e-03 -1.300032e-03 -1.358474e-03
## ASV0446      1.785404e-03  1.868695e-03  1.955787e-03  2.046845e-03
## ASV0367     -1.172108e-03 -1.226252e-03 -1.282821e-03 -1.341915e-03
## ASV0200     -6.974093e-04 -7.295856e-04 -7.631984e-04 -7.983072e-04
## ASV0334     -3.867547e-04 -4.026394e-04 -4.190570e-04 -4.360142e-04
## ASV1311      4.651270e-04  4.849460e-04  5.054982e-04  5.268002e-04
## ASV0458      6.889470e-04  7.179536e-04  7.480044e-04  7.791206e-04
## ASV1371      1.083777e-04  1.137363e-04  1.193656e-04  1.252795e-04
## ASV0418      1.565419e-03  1.634947e-03  1.707334e-03  1.782678e-03
## ASV0004      2.271525e-04  2.371926e-04  2.476406e-04  2.585101e-04
## ASV1943      4.401074e-03  4.583971e-03  4.773271e-03  4.969095e-03
## ASV1495     -2.991518e-04 -3.158354e-04 -3.335320e-04 -3.523085e-04
## ASV0901     -1.312665e-03 -1.374220e-03 -1.438618e-03 -1.505987e-03
## ASV0628      7.078667e-04  7.386479e-04  7.706291e-04  8.038442e-04
## ASV0400      4.282915e-04  4.474558e-04  4.674191e-04  4.882093e-04
## ASV0116     -3.861621e-04 -4.042357e-04 -4.231408e-04 -4.429142e-04
## ASV0788      3.411937e-03  3.571972e-03  3.739402e-03  3.914557e-03
## ASV0117      2.501683e-04  2.622006e-04  2.748154e-04  2.880413e-04
## ASV3137     -8.057213e-05 -8.418094e-05 -8.794087e-05 -9.185729e-05
## ASV0001      2.441174e-04  2.548561e-04  2.660262e-04  2.776412e-04
## ASV1651      6.944986e-04  7.253016e-04  7.573665e-04  7.907359e-04
## ASV1692      2.842398e-03  2.975517e-03  3.114765e-03  3.260415e-03
## ASV0660      1.030462e-03  1.074857e-03  1.120941e-03  1.168757e-03
## ASV0508      5.192084e-05  5.410275e-05  5.636300e-05  5.870319e-05
## ASV1660     -5.673663e-04 -5.952548e-04 -6.245432e-04 -6.553031e-04
## ASV0233      8.805703e-04  9.211578e-04  9.635546e-04  1.007836e-03
## ASV1343     -1.619585e-03 -1.695235e-03 -1.774350e-03 -1.857083e-03
## ASV0209      8.161566e-04  8.521249e-04  8.895441e-04  9.284609e-04
## ASV0193     -9.517476e-04 -9.939559e-04 -1.037891e-03 -1.083611e-03
## ASV0357      3.561720e-04  3.741525e-04  3.930829e-04  4.130167e-04
## ASV0198      7.200858e-04  7.526533e-04  7.866153e-04  8.220246e-04
## ASV0007      2.160292e-04  2.254098e-04  2.351554e-04  2.452764e-04
## ASV1772     -3.224861e-04 -3.362273e-04 -3.504701e-04 -3.652243e-04
## ASV0009      1.789500e-04  1.866107e-04  1.945589e-04  2.028017e-04
## ASV0006     -1.917196e-04 -2.008986e-04 -2.105184e-04 -2.206003e-04
## ASV0011     -6.684219e-04 -6.995280e-04 -7.320477e-04 -7.660423e-04
## ASV0015      1.352645e-04  1.410519e-04  1.470559e-04  1.532818e-04
## ASV0017      1.523569e-04  1.588825e-04  1.656533e-04  1.726756e-04
## ASV0235     -6.170141e-04 -6.458758e-04 -6.760617e-04 -7.076302e-04
## ASV0382      4.829690e-04  5.055687e-04  5.292022e-04  5.539141e-04
## ASV2357      2.014101e-03  2.107715e-03  2.205575e-03  2.307865e-03
## ASV0567     -3.896286e-04 -4.078645e-04 -4.269419e-04 -4.468988e-04
## ASV0165      3.360404e-04  3.516597e-04  3.679866e-04  3.850514e-04
## ASV0005      4.890951e-04  5.114414e-04  5.347645e-04  5.591030e-04
## ASV0384     -5.680396e-05 -5.850853e-05 -6.020334e-05 -6.188000e-05
## ASV0002      9.195124e-05  9.604411e-05  1.003065e-04  1.047443e-04
## ASV3017      2.603855e-03  2.719504e-03  2.839901e-03  2.965208e-03
## ASV0091     -6.584666e-05 -6.880790e-05 -7.189539e-05 -7.511403e-05
## ASV0186     -9.849981e-04 -1.030212e-03 -1.077421e-03 -1.126707e-03
## ASV0370      5.238710e-04  5.475592e-04  5.722595e-04  5.980095e-04
## ASV0018      6.262709e-04  6.549578e-04  6.849055e-04  7.161647e-04
## ASV1377      6.306756e-03  6.588809e-03  6.882634e-03  7.188647e-03
## ASV0019      6.569221e-04  6.870358e-04  7.184752e-04  7.512938e-04
## ASV0023     -4.089981e-04 -4.281644e-04 -4.482136e-04 -4.691850e-04
## ASV2194      6.563260e-04  6.873584e-04  7.198484e-04  7.538637e-04
## ASV1155      2.639993e-03  2.757680e-03  2.880270e-03  3.007936e-03
## ASV0510     -7.123731e-04 -7.429676e-04 -7.747164e-04 -8.076485e-04
## ASV2371     -1.589561e-03 -1.660480e-03 -1.734353e-03 -1.811285e-03
## ASV0024     -5.095302e-04 -5.333470e-04 -5.582555e-04 -5.843037e-04
## ASV2452      1.603981e-03  1.673828e-03  1.746407e-03  1.821798e-03
## ASV2332     -4.558591e-03 -4.763488e-03 -4.977063e-03 -5.199638e-03
## ASV2591      1.169095e-03  1.227673e-03  1.289267e-03  1.354035e-03
## ASV0521      1.035447e-03  1.083789e-03  1.134344e-03  1.187208e-03
## ASV5542      9.909380e-04  1.037286e-03  1.085753e-03  1.136431e-03
## ASV0336     -1.206594e-04 -1.273337e-04 -1.344065e-04 -1.419033e-04
## ASV10102     1.831580e-03  1.917047e-03  2.006414e-03  2.099851e-03
## ASV16823    -2.861780e-03 -2.987007e-03 -3.117226e-03 -3.252595e-03
## ASV3104      1.480519e-02  1.545293e-02  1.612649e-02  1.682668e-02
## ASV0781      2.050519e-03  2.144292e-03  2.242174e-03  2.344329e-03
## ASV10899     1.181889e-03  1.241262e-03  1.303728e-03  1.369454e-03
## ASV11222    -5.035919e-03 -5.256231e-03 -5.485321e-03 -5.723467e-03
## ASV11327    -4.520669e-03 -4.718407e-03 -4.924022e-03 -5.137763e-03
## ASV12458    -5.034366e-03 -5.254539e-03 -5.483480e-03 -5.721463e-03
## ASV1636      2.830529e-03  2.957735e-03  3.090305e-03  3.228434e-03
## ASV1890     -2.328131e-03 -2.426888e-03 -2.529298e-03 -2.635450e-03
## ASV2898      3.794724e-03  3.965375e-03  4.143238e-03  4.328578e-03
## ASV8328      4.096954e-04  4.368944e-04  4.660582e-04  4.973348e-04
## ASV0709     -4.221293e-03 -4.413314e-03 -4.613643e-03 -4.822602e-03
## ASV0856      3.477886e-03  3.642433e-03  3.814697e-03  3.995032e-03
## ASV0909      9.805076e-04  1.032070e-03  1.086518e-03  1.144023e-03
## ASV0937     -2.469997e-03 -2.584955e-03 -2.705153e-03 -2.830821e-03
## ASV11390    -7.184213e-03 -7.498368e-03 -7.825031e-03 -8.164594e-03
## ASV11966     1.696706e-03  1.778440e-03  1.864131e-03  1.953970e-03
## ASV12990     1.248976e-03  1.304824e-03  1.362993e-03  1.423564e-03
## ASV14797     1.853607e-03  1.935710e-03  2.021165e-03  2.110082e-03
## ASV14904    -1.030877e-02 -1.075955e-02 -1.122827e-02 -1.171549e-02
## ASV15304     1.055662e-03  1.108120e-03  1.163254e-03  1.221203e-03
## ASV16696    -3.561468e-03 -3.717184e-03 -3.879098e-03 -4.047404e-03
## ASV1690      5.906564e-03  6.186821e-03  6.480262e-03  6.787489e-03
## ASV2029      4.152917e-03  4.341124e-03  4.537426e-03  4.742133e-03
## ASV2834      5.179397e-03  5.419460e-03  5.670339e-03  5.932494e-03
## ASV4003      4.219551e-03  4.422875e-03  4.636082e-03  4.859657e-03
## ASV4064      2.454497e-03  2.568966e-03  2.688651e-03  2.813780e-03
## ASV4294      1.461687e-03  1.534194e-03  1.610402e-03  1.690505e-03
## ASV4609      1.405587e-03  1.469111e-03  1.535343e-03  1.604383e-03
## ASV6283     -3.329454e-03 -3.475042e-03 -3.626427e-03 -3.783791e-03
## ASV6491     -4.771408e-03 -4.980016e-03 -5.196926e-03 -5.422401e-03
## ASV7453      2.247701e-03  2.356477e-03  2.470561e-03  2.590215e-03
## ASV7959      7.921542e-04  8.336369e-04  8.774154e-04  9.236240e-04
## ASV8219      4.123202e-02  4.303458e-02  4.490888e-02  4.685718e-02
## ASV8547     -4.270874e-03 -4.457556e-03 -4.651665e-03 -4.853434e-03
## ASV9319      1.825297e-03  1.911415e-03  2.001551e-03  2.095886e-03
## ASV9382     -8.355790e-03 -8.720996e-03 -9.100728e-03 -9.495442e-03
## ASV11516    -5.580139e-03 -5.823991e-03 -6.077538e-03 -6.341086e-03
## ASV14377    -4.028542e-03 -4.204560e-03 -4.387576e-03 -4.577806e-03
## ASV1867      3.071151e-03  3.214312e-03  3.363998e-03  3.520494e-03
## ASV1895      1.568322e-03  1.636711e-03  1.707774e-03  1.781588e-03
## ASV3168      1.966356e-03  2.053521e-03  2.144240e-03  2.238628e-03
## ASV4449      1.075354e-02  1.124429e-02  1.175651e-02  1.229106e-02
## ASV6596      2.201507e-03  2.308774e-03  2.421357e-03  2.539526e-03
## ASV7492     -4.410933e-04 -4.548792e-04 -4.686964e-04 -4.824960e-04
## ASV9854     -8.642758e-04 -9.015097e-04 -9.401820e-04 -9.803347e-04
## ASV6296      6.758846e-02  7.054104e-02  7.361094e-02  7.680182e-02
## ASV4201      2.869792e-04  3.067915e-04  3.280827e-04  3.509668e-04
## ASV0552      2.126939e-03  2.225749e-03  2.329032e-03  2.436979e-03
## ASV3671     -1.427146e-03 -1.491596e-03 -1.558816e-03 -1.628916e-03
## ASV3529     -3.979789e-04 -4.109760e-04 -4.240863e-04 -4.372760e-04
## ASV1060      5.625833e-04  5.893105e-04  6.173056e-04  6.466287e-04
## ASV0239     -7.779727e-04 -8.116932e-04 -8.467220e-04 -8.830961e-04
## ASV5711     -3.492882e-03 -3.649861e-03 -3.813490e-03 -3.984017e-03
## ASV4152     -4.912773e-03 -5.138678e-03 -5.374613e-03 -5.620994e-03
## ASV1461      2.506855e-03  2.616206e-03  2.729861e-03  2.847946e-03
## ASV2877      1.299113e-03  1.356320e-03  1.415826e-03  1.477705e-03
## ASV0012      2.221358e-04  2.323215e-04  2.429566e-04  2.540594e-04
## ASV9823      3.265985e-04  3.395141e-04  3.528026e-04  3.664605e-04
## ASV0008      2.372575e-04  2.480794e-04  2.593736e-04  2.711590e-04
## ASV7832     -2.889520e-03 -3.022870e-03 -3.162199e-03 -3.307761e-03
## ASV1915     -3.703808e-04 -3.867335e-04 -4.037602e-04 -4.214853e-04
## ASV0055     -2.507855e-04 -2.632194e-04 -2.762883e-04 -2.900260e-04
## ASV0032      1.213395e-04  1.263149e-04  1.314560e-04  1.367646e-04
## ASV2977     -4.079006e-03 -4.266020e-03 -4.461287e-03 -4.665141e-03
## ASV0466      3.316363e-03  3.461120e-03  3.611587e-03  3.767938e-03
## ASV3866      2.229437e-03  2.333864e-03  2.443100e-03  2.557359e-03
## ASV0040      8.079384e-04  8.452885e-04  8.843138e-04  9.250845e-04
## ASV0496     -1.762938e-04 -1.874357e-04 -1.993514e-04 -2.120980e-04
## ASV0052      6.781234e-04  7.095104e-04  7.423080e-04  7.765758e-04
## ASV3828     -2.395297e-03 -2.499686e-03 -2.608198e-03 -2.720962e-03
## ASV1930      1.221290e-03  1.275892e-03  1.332765e-03  1.391988e-03
## ASV2126      2.074698e-03  2.168788e-03  2.266931e-03  2.369281e-03
## ASV0793      2.527664e-03  2.645667e-03  2.769065e-03  2.898096e-03
## ASV0299     -4.924822e-05 -5.161601e-05 -5.410421e-05 -5.672004e-05
## ASV0208      1.829692e-03  1.914235e-03  2.002568e-03  2.094848e-03
## ASV0511     -7.647474e-04 -7.978215e-04 -8.321670e-04 -8.678181e-04
## ASV1123     -2.310434e-03 -2.410992e-03 -2.515495e-03 -2.624059e-03
## ASV0099      6.656196e-05  6.998494e-05  7.359542e-05  7.740468e-05
## ASV0752     -1.293415e-03 -1.354921e-03 -1.419339e-03 -1.486805e-03
## ASV0883      1.775709e-03  1.859854e-03  1.947958e-03  2.040201e-03
## ASV0683      2.326076e-03  2.435405e-03  2.549799e-03  2.669485e-03
## ASV4117     -3.722291e-03 -3.894088e-03 -4.073580e-03 -4.261091e-03
## ASV2172      2.487827e-04  2.589115e-04  2.693660e-04  2.801479e-04
## ASV0330     -6.941764e-04 -7.264655e-04 -7.602213e-04 -7.955072e-04
## ASV0728      3.442437e-03  3.600159e-03  3.764814e-03  3.936678e-03
## ASV0499      9.045371e-04  9.471715e-04  9.917939e-04  1.038495e-03
## ASV0120     -1.526163e-03 -1.596210e-03 -1.669348e-03 -1.745702e-03
## ASV1446      1.200992e-03  1.250569e-03  1.301835e-03  1.354815e-03
## ASV17171    -2.951052e-03 -3.085944e-03 -3.226762e-03 -3.373747e-03
## ASV0533      2.161758e-04  2.267267e-04  2.378018e-04  2.494276e-04
## ASV2495     -7.061195e-04 -7.414751e-04 -7.786776e-04 -8.178299e-04
## ASV5582      1.389629e-03  1.448477e-03  1.509472e-03  1.572660e-03
## ASV1488      5.245507e-04  5.479192e-04  5.722514e-04  5.975801e-04
## ASV0682      6.582348e-04  6.894089e-04  7.220490e-04  7.562231e-04
## ASV0068     -1.154759e-03 -1.207957e-03 -1.263520e-03 -1.321547e-03
## ASV1987     -2.849883e-03 -2.985759e-03 -3.128101e-03 -3.277214e-03
## ASV0035     -2.030448e-04 -2.142888e-04 -2.262128e-04 -2.388621e-04
## ASV7192     -1.798378e-03 -1.879366e-03 -1.963795e-03 -2.051792e-03
## ASV0873     -1.004428e-05 -4.661334e-05 -8.799132e-05 -1.346459e-04
## ASV4749     -2.517476e-05 -3.239685e-05 -4.050067e-05 -4.957369e-05
## ASV2174      1.266015e-03  1.320202e-03  1.376419e-03  1.434717e-03
## ASV1476     -1.266468e-03 -1.326279e-03 -1.388896e-03 -1.454452e-03
## ASV0740     -3.597258e-03 -3.766951e-03 -3.944568e-03 -4.130471e-03
## ASV0170     -7.081758e-04 -7.408254e-04 -7.749310e-04 -8.105531e-04
## ASV2466     -3.228643e-03 -3.377490e-03 -3.532986e-03 -3.695409e-03
## ASV1709      1.194503e-03  1.247617e-03  1.302944e-03  1.360564e-03
## ASV6170     -5.037175e-03 -5.272719e-03 -5.519076e-03 -5.776722e-03
## ASV3673      2.468312e-03  2.584713e-03  2.706546e-03  2.834060e-03
## ASV1745     -6.341400e-04 -6.649746e-04 -6.973322e-04 -7.312896e-04
##                                                                    
## (Intercept)  2.059616e-02  2.154032e-02  2.252598e-02  2.355480e-02
## ASV1236      4.079697e-03  4.260354e-03  4.448405e-03  4.644103e-03
## ASV0421      4.588552e-04  4.834488e-04  5.094483e-04  5.369391e-04
## ASV0691     -3.188907e-03 -3.321600e-03 -3.458942e-03 -3.601018e-03
## ASV0899      3.534291e-03  3.691572e-03  3.855336e-03  4.025804e-03
## ASV1004      8.166402e-03  8.529214e-03  8.906960e-03  9.300149e-03
## ASV1041     -3.359511e-03 -3.508096e-03 -3.662713e-03 -3.823555e-03
## ASV1058      5.097620e-03  5.323718e-03  5.559095e-03  5.804066e-03
## ASV12542     1.979304e-03  2.065399e-03  2.154873e-03  2.247827e-03
## ASV1294      4.743653e-03  4.954334e-03  5.173685e-03  5.402006e-03
## ASV13113     1.577069e-03  1.652523e-03  1.731598e-03  1.814467e-03
## ASV1318      4.730459e-03  4.940398e-03  5.158958e-03  5.386434e-03
## ASV2269     -8.192577e-03 -8.555149e-03 -8.932501e-03 -9.325124e-03
## ASV2542      3.979795e-03  4.164702e-03  4.357992e-03  4.560026e-03
## ASV2660     -3.261239e-03 -3.404860e-03 -3.554275e-03 -3.709670e-03
## ASV2737      1.131734e-03  1.179804e-03  1.229657e-03  1.281336e-03
## ASV2840      4.353742e-03  4.541587e-03  4.736636e-03  4.939085e-03
## ASV3053      2.227136e-02  2.324232e-02  2.425159e-02  2.530033e-02
## ASV3077      1.420155e-03  1.482286e-03  1.546891e-03  1.614049e-03
## ASV3134      2.519956e-03  2.638966e-03  2.763549e-03  2.893960e-03
## ASV3140      3.423592e-03  3.580231e-03  3.743741e-03  3.914396e-03
## ASV3579      1.207812e-03  1.267013e-03  1.329176e-03  1.394454e-03
## ASV6119     -2.241855e-03 -2.341051e-03 -2.444290e-03 -2.551705e-03
## ASV7557     -4.555123e-03 -4.756637e-03 -4.966358e-03 -5.184559e-03
## ASV8422      1.136456e-03  1.186078e-03  1.237667e-03  1.291284e-03
## ASV1086     -1.781747e-04 -1.853607e-04 -1.927789e-04 -2.004321e-04
## ASV1310      2.182580e-03  2.279319e-03  2.380016e-03  2.484806e-03
## ASV15750    -2.979274e-04 -3.104577e-04 -3.234361e-04 -3.368711e-04
## ASV16905    -9.366854e-04 -9.781230e-04 -1.021249e-03 -1.066118e-03
## ASV2033      3.993774e-03  4.180974e-03  4.376795e-03  4.581617e-03
## ASV2089      1.975070e-03  2.062524e-03  2.153548e-03  2.248260e-03
## ASV2127      6.414784e-03  6.699123e-03  6.995110e-03  7.303138e-03
## ASV2725      5.135249e-03  5.359931e-03  5.593544e-03  5.836367e-03
## ASV2804     -1.938892e-03 -2.024659e-03 -2.113918e-03 -2.206785e-03
## ASV3075      4.247628e-03  4.440469e-03  4.641666e-03  4.851547e-03
## ASV3327      5.870553e-03  6.142619e-03  6.426942e-03  6.724042e-03
## ASV3342      5.046424e-03  5.278992e-03  5.521925e-03  5.775655e-03
## ASV3532     -5.569849e-03 -5.824073e-03 -6.089411e-03 -6.366307e-03
## ASV3600      2.588635e-03  2.707252e-03  2.831096e-03  2.960379e-03
## ASV4013      4.831175e-03  5.048526e-03  5.275078e-03  5.511168e-03
## ASV4136      5.155429e-03  5.381493e-03  5.616608e-03  5.861063e-03
## ASV4195      1.978883e-02  2.066399e-02  2.157478e-02  2.252236e-02
## ASV4407     -7.644653e-03 -7.982670e-03 -8.334442e-03 -8.700421e-03
## ASV4717      1.332211e-03  1.388232e-03  1.446274e-03  1.506382e-03
## ASV6794      3.169821e-03  3.306907e-03  3.449310e-03  3.597186e-03
## ASV8324     -3.922666e-03 -4.096112e-03 -4.276617e-03 -4.464411e-03
## ASV8981     -9.800442e-05 -1.004319e-04 -1.027758e-04 -1.050157e-04
## ASV9859      1.357678e-03  1.425156e-03  1.496100e-03  1.570695e-03
## ASV0936      3.804660e-03  3.980197e-03  4.163564e-03  4.355083e-03
## ASV12683    -4.042982e-06 -4.859652e-06 -5.765430e-06 -6.767965e-06
## ASV1293      2.544714e-03  2.657041e-03  2.773924e-03  2.895514e-03
## ASV13055    -6.062280e-05 -6.190778e-05 -6.311162e-05 -6.421853e-05
## ASV17063    -2.034264e-03 -2.124149e-03 -2.217685e-03 -2.314994e-03
## ASV2228      1.658737e-03  1.732015e-03  1.808268e-03  1.887595e-03
## ASV2769      2.604558e-04  2.740996e-04  2.884961e-04  3.036888e-04
## ASV2803      1.795783e-03  1.872868e-03  1.952882e-03  2.035901e-03
## ASV2896      1.435053e-03  1.501735e-03  1.571448e-03  1.644326e-03
## ASV3062      1.731584e-03  1.815207e-03  1.902904e-03  1.994875e-03
## ASV3107      2.674745e-03  2.798129e-03  2.927029e-03  3.061675e-03
## ASV3265      3.640900e-03  3.801269e-03  3.968109e-03  4.141627e-03
## ASV3666      3.533431e-05  3.666874e-05  3.803318e-05  3.942592e-05
## ASV4497      1.250740e-03  1.306449e-03  1.364464e-03  1.424867e-03
## ASV6914     -1.868825e-04 -1.964834e-04 -2.066020e-04 -2.172675e-04
## ASV0576     -4.346623e-03 -4.531824e-03 -4.723932e-03 -4.923118e-03
## ASV0673      4.817016e-03  5.033026e-03  5.258112e-03  5.492600e-03
## ASV0772      2.235847e-03  2.336797e-03  2.442059e-03  2.551795e-03
## ASV0862      2.150637e-04  2.301194e-04  2.463063e-04  2.637110e-04
## ASV0898      1.736629e-03  1.818535e-03  1.904252e-03  1.993955e-03
## ASV0910      2.004839e-03  2.097768e-03  2.194891e-03  2.296384e-03
## ASV0964     -1.643320e-03 -1.714157e-03 -1.787708e-03 -1.864047e-03
## ASV10059     1.426476e-03  1.494455e-03  1.565668e-03  1.640268e-03
## ASV10263    -3.099336e-03 -3.236438e-03 -3.379125e-03 -3.527582e-03
## ASV1088      3.574840e-03  3.739204e-03  3.910877e-03  4.090165e-03
## ASV1101      4.430883e-03  4.626368e-03  4.829767e-03  5.041339e-03
## ASV1183      1.171697e-03  1.225155e-03  1.280948e-03  1.339167e-03
## ASV11956     1.134305e-03  1.182454e-03  1.232383e-03  1.284136e-03
## ASV12774     6.561738e-05  6.688803e-05  6.805605e-05  6.910315e-05
## ASV1321      5.176126e-03  5.417686e-03  5.670290e-03  5.934421e-03
## ASV13793    -2.136876e-03 -2.231393e-03 -2.329760e-03 -2.432103e-03
## ASV14482     1.361614e-04  1.415891e-04  1.471894e-04  1.529643e-04
## ASV15483     8.791615e-04  9.198202e-04  9.623024e-04  1.006685e-03
## ASV2062      4.097238e-03  4.281197e-03  4.472916e-03  4.672681e-03
## ASV2132      3.345366e-03  3.499675e-03  3.660870e-03  3.829236e-03
## ASV2413      3.167934e-03  3.308481e-03  3.454804e-03  3.607101e-03
## ASV2490      9.752449e-03  1.017651e-02  1.061720e-02  1.107500e-02
## ASV2594      1.219186e-03  1.274914e-03  1.333094e-03  1.393828e-03
## ASV2822     -5.639930e-03 -5.889506e-03 -6.149258e-03 -6.419523e-03
## ASV2863      6.000830e-03  6.264053e-03  6.537820e-03  6.822469e-03
## ASV2910      2.195853e-03  2.292829e-03  2.393744e-03  2.498729e-03
## ASV2980      2.450244e-03  2.560539e-03  2.675510e-03  2.795328e-03
## ASV3307      4.486730e-03  4.685197e-03  4.891748e-03  5.106652e-03
## ASV3474      2.963812e-03  3.103309e-03  3.249285e-03  3.402034e-03
## ASV3502      3.113406e-03  3.255031e-03  3.402799e-03  3.556951e-03
## ASV4236      4.585322e-03  4.783638e-03  4.989614e-03  5.203465e-03
## ASV4842     -4.926871e-04 -5.158547e-04 -5.400772e-04 -5.653977e-04
## ASV4894     -2.137499e-03 -2.232079e-03 -2.330514e-03 -2.432933e-03
## ASV5290      1.697648e-03  1.775715e-03  1.857242e-03  1.942370e-03
## ASV5501      1.038001e-03  1.085211e-03  1.134478e-03  1.185885e-03
## ASV5795      1.140745e-03  1.193343e-03  1.248286e-03  1.305671e-03
## ASV5987     -5.970758e-03 -6.235003e-03 -6.510025e-03 -6.796183e-03
## ASV6267     -6.726999e-03 -7.024653e-03 -7.334442e-03 -7.656769e-03
## ASV6862      2.700891e-03  2.818438e-03  2.940609e-03  3.067543e-03
## ASV7145      1.192683e-03  1.243797e-03  1.296861e-03  1.351929e-03
## ASV7673     -2.137359e-03 -2.231928e-03 -2.330352e-03 -2.432759e-03
## ASV7789      1.058034e-03  1.110215e-03  1.165036e-03  1.222636e-03
## ASV7809      7.152030e-05  7.673160e-05  8.234658e-05  8.839682e-05
## ASV8002     -2.699350e-03 -2.818784e-03 -2.943086e-03 -3.072420e-03
## ASV8205      1.129975e-03  1.181756e-03  1.235820e-03  1.292260e-03
## ASV9155     -6.864946e-04 -7.162971e-04 -7.472603e-04 -7.794175e-04
## ASV9221      2.760088e-04  2.918356e-04  3.086514e-04  3.265228e-04
## ASV9311     -4.329994e-03 -4.521559e-03 -4.720933e-03 -4.928375e-03
## ASV9557     -2.958853e-03 -3.089731e-03 -3.225941e-03 -3.367662e-03
## ASV9936     -5.966177e-03 -6.230025e-03 -6.504619e-03 -6.790314e-03
## ASV1445      3.622866e-03  3.789017e-03  3.962497e-03  4.143602e-03
## ASV4232      1.369566e-03  1.434843e-03  1.503238e-03  1.574900e-03
## ASV6479      4.863533e-04  5.129991e-04  5.412164e-04  5.711045e-04
## ASV0142     -2.572509e-03 -2.685586e-03 -2.803209e-03 -2.925524e-03
## ASV0378      1.166636e-03  1.222259e-03  1.280530e-03  1.341574e-03
## ASV1122      3.505992e-03  3.667732e-03  3.836694e-03  4.013177e-03
## ASV0123     -2.271819e-03 -2.371509e-03 -2.475192e-03 -2.582992e-03
## ASV2064      1.163605e-03  1.212744e-03  1.263664e-03  1.316403e-03
## ASV4459     -1.632167e-04 -1.695427e-04 -1.760476e-04 -1.827306e-04
## ASV0448      9.328596e-04  9.773905e-04  1.024045e-03  1.072923e-03
## ASV0397      2.062344e-03  2.155692e-03  2.253044e-03  2.354554e-03
## ASV0485      2.397672e-03  2.504959e-03  2.616740e-03  2.733176e-03
## ASV1566      3.531156e-03  3.690609e-03  3.856866e-03  4.030182e-03
## ASV1365      3.014607e-03  3.152153e-03  3.295693e-03  3.445463e-03
## ASV1065      4.284557e-03  4.479638e-03  4.683195e-03  4.895559e-03
## ASV0722     -2.234036e-04 -2.339204e-04 -2.449293e-04 -2.564532e-04
## ASV12660    -2.462426e-03 -2.570063e-03 -2.681981e-03 -2.798313e-03
## ASV0223      6.622729e-04  6.920168e-04  7.230186e-04  7.553249e-04
## ASV0229      1.009612e-03  1.056279e-03  1.105039e-03  1.155983e-03
## ASV0877      4.251007e-04  4.428660e-04  4.612454e-04  4.802472e-04
## ASV0983      2.380330e-03  2.486317e-03  2.596688e-03  2.711596e-03
## ASV0626      2.539788e-04  2.689606e-04  2.849000e-04  3.018613e-04
## ASV4146      1.171624e-04  1.223241e-04  1.276817e-04  1.332386e-04
## ASV4175     -2.930454e-03 -3.065320e-03 -3.206177e-03 -3.353271e-03
## ASV2082     -1.313404e-03 -1.380604e-03 -1.451419e-03 -1.526056e-03
## ASV2272      1.395638e-03  1.459572e-03  1.526327e-03  1.596016e-03
## ASV2245     -2.092491e-03 -2.189264e-03 -2.290376e-03 -2.396010e-03
## ASV0590     -1.236933e-03 -1.302184e-03 -1.371095e-03 -1.443886e-03
## ASV0217      1.049717e-04  1.146809e-04  1.252594e-04  1.367811e-04
## ASV0416      1.595144e-03  1.661816e-03  1.730842e-03  1.802266e-03
## ASV1056      2.022441e-03  2.117190e-03  2.216297e-03  2.319954e-03
## ASV7777     -2.852719e-03 -2.983343e-03 -3.119717e-03 -3.262075e-03
## ASV0455      5.121197e-04  5.354016e-04  5.596907e-04  5.850260e-04
## ASV0604      1.330847e-03  1.393884e-03  1.459881e-03  1.528973e-03
## ASV6100     -1.964821e-03 -2.055812e-03 -2.150902e-03 -2.250268e-03
## ASV11359    -4.225563e-03 -4.419099e-03 -4.621145e-03 -4.832041e-03
## ASV6604      5.853588e-04  6.129648e-04  6.418570e-04  6.720937e-04
## ASV5004     -1.503387e-03 -1.571768e-03 -1.643117e-03 -1.717551e-03
## ASV1483     -6.477295e-04 -6.770102e-04 -7.075435e-04 -7.393765e-04
## ASV9773     -1.903098e-03 -1.990689e-03 -2.082175e-03 -2.177718e-03
## ASV4059      1.230152e-06  5.014133e-06  9.303857e-06  1.414994e-05
## ASV1193      2.300666e-03  2.404931e-03  2.513681e-03  2.627087e-03
## ASV4610     -3.661226e-04 -3.775800e-04 -3.890797e-04 -4.005850e-04
## ASV0742     -2.213673e-04 -2.271353e-04 -2.327659e-04 -2.382197e-04
## ASV1502     -1.018040e-04 -1.091319e-04 -1.170235e-04 -1.255230e-04
## ASV0195      5.676955e-05  5.769748e-05  5.851858e-05  5.921598e-05
## ASV1213      1.623969e-03  1.693413e-03  1.765467e-03  1.840201e-03
## ASV1648     -1.764765e-03 -1.846350e-03 -1.931601e-03 -2.020674e-03
## ASV6984     -1.651099e-03 -1.727503e-03 -1.807348e-03 -1.890782e-03
## ASV0396     -9.473409e-05 -9.720062e-05 -9.961228e-05 -1.019534e-04
## ASV4297      2.354384e-03  2.456789e-03  2.563205e-03  2.673751e-03
## ASV2622      3.649998e-03  3.811812e-03  3.980261e-03  4.155568e-03
## ASV3512      1.416841e-03  1.486775e-03  1.560256e-03  1.637471e-03
## ASV2411      2.483096e-03  2.599751e-03  2.721808e-03  2.849509e-03
## ASV2291     -1.068527e-03 -1.125776e-03 -1.186300e-03 -1.250300e-03
## ASV0807      3.388469e-03  3.542115e-03  3.702374e-03  3.869500e-03
## ASV1292      8.199389e-04  8.542125e-04  8.897006e-04  9.264268e-04
## ASV1035      3.109868e-03  3.246542e-03  3.388724e-03  3.536593e-03
## ASV0070      2.592338e-05  2.888531e-05  3.214154e-05  3.571889e-05
## ASV0255      2.949844e-04  3.073748e-04  3.202046e-04  3.334815e-04
## ASV0057     -8.561783e-04 -8.928395e-04 -9.308809e-04 -9.703377e-04
## ASV0077     -1.819354e-04 -1.890515e-04 -1.963698e-04 -2.038887e-04
## ASV0625      1.791010e-03  1.869123e-03  1.950318e-03  2.034689e-03
## ASV2464      1.218761e-02  1.271684e-02  1.326681e-02  1.383816e-02
## ASV1315      3.234892e-03  3.387562e-03  3.547362e-03  3.714616e-03
## ASV2673      2.774736e-03  2.905870e-03  3.043145e-03  3.186841e-03
## ASV2161      1.173485e-03  1.228775e-03  1.286642e-03  1.347205e-03
## ASV0337     -6.720828e-04 -7.030914e-04 -7.354841e-04 -7.693186e-04
## ASV7680     -4.386083e-03 -4.589037e-03 -4.801111e-03 -5.022689e-03
## ASV0611      2.449623e-03  2.563140e-03  2.681776e-03  2.805751e-03
## ASV3118     -2.542923e-03 -2.663670e-03 -2.790119e-03 -2.922534e-03
## ASV1284      9.107706e-04  9.404108e-04  9.702509e-04  1.000200e-03
## ASV0889      1.853281e-03  1.935939e-03  2.022038e-03  2.111700e-03
## ASV4649     -9.284650e-04 -9.708583e-04 -1.015106e-03 -1.061282e-03
## ASV1108     -1.902387e-03 -1.993857e-03 -2.089753e-03 -2.190291e-03
## ASV0738      1.050799e-03  1.103971e-03  1.159949e-03  1.218887e-03
## ASV0473     -2.133049e-04 -2.251642e-04 -2.377266e-04 -2.510353e-04
## ASV0598     -5.367863e-04 -5.649136e-04 -5.946089e-04 -6.259659e-04
## ASV0429      1.375479e-03  1.435909e-03  1.498757e-03  1.564101e-03
## ASV1549      2.560198e-03  2.681362e-03  2.808215e-03  2.941019e-03
## ASV1203      2.015487e-03  2.105729e-03  2.199752e-03  2.297689e-03
## ASV4532      8.663477e-05  8.971311e-05  9.285198e-05  9.604802e-05
## ASV0274      3.513964e-04  3.686822e-04  3.868328e-04  4.058918e-04
## ASV0163     -1.556086e-03 -1.623698e-03 -1.693959e-03 -1.766948e-03
## ASV1298      1.700955e-04  1.767247e-04  1.835503e-04  1.905732e-04
## ASV9424     -3.400319e-03 -3.558390e-03 -3.723639e-03 -3.896377e-03
## ASV0412      3.496440e-03  3.652044e-03  3.814086e-03  3.982793e-03
## ASV0284      7.302303e-04  7.600051e-04  7.907577e-04  8.224980e-04
## ASV0620     -7.187704e-04 -7.551711e-04 -7.934906e-04 -8.338347e-04
## ASV0153     -3.422881e-03 -3.584823e-03 -3.754359e-03 -3.931839e-03
## ASV0498      1.207259e-03  1.263186e-03  1.321623e-03  1.382676e-03
## ASV0097      6.724150e-04  7.042155e-04  7.375081e-04  7.723616e-04
## ASV0104     -4.748483e-03 -4.962832e-03 -5.186316e-03 -5.419277e-03
## ASV1282      1.636553e-03  1.708147e-03  1.782576e-03  1.859923e-03
## ASV3883     -1.305135e-03 -1.368971e-03 -1.435980e-03 -1.506323e-03
## ASV0801      6.438717e-04  6.736594e-04  7.047831e-04  7.372987e-04
## ASV1611     -3.048963e-03 -3.191937e-03 -3.341508e-03 -3.497972e-03
## ASV0227     -5.520301e-04 -5.809091e-04 -6.113831e-04 -6.435449e-04
## ASV0833      1.036325e-03  1.084078e-03  1.133955e-03  1.186043e-03
## ASV0718      4.635785e-03  4.848520e-03  5.070658e-03  5.302583e-03
## ASV1139      5.952772e-04  6.178501e-04  6.409846e-04  6.646645e-04
## ASV0766     -6.490422e-04 -6.808834e-04 -7.143135e-04 -7.494127e-04
## ASV2091      3.761302e-03  3.925523e-03  4.096236e-03  4.273637e-03
## ASV1238     -3.448634e-03 -3.609241e-03 -3.777178e-03 -3.952768e-03
## ASV9193     -3.330625e-04 -3.523705e-04 -3.729059e-04 -3.947531e-04
## ASV0290      4.897049e-04  5.092820e-04  5.294687e-04  5.502684e-04
## ASV0231      1.376350e-03  1.437585e-03  1.501350e-03  1.567731e-03
## ASV0185      8.061799e-04  8.468161e-04  8.895834e-04  9.345992e-04
## ASV2330      1.575969e-03  1.643765e-03  1.714147e-03  1.787184e-03
## ASV3119     -7.298725e-04 -7.664407e-04 -8.049062e-04 -8.453717e-04
## ASV2368     -1.771070e-03 -1.855071e-03 -1.943043e-03 -2.035174e-03
## ASV0122     -8.556685e-04 -8.940832e-04 -9.341179e-04 -9.758318e-04
## ASV1044      2.196792e-03  2.299846e-03  2.407659e-03  2.520446e-03
## ASV0160     -9.174855e-04 -9.570404e-04 -9.981133e-04 -1.040746e-03
## ASV0326      2.430200e-04  2.542429e-04  2.659655e-04  2.782082e-04
## ASV1388      4.439370e-03  4.639387e-03  4.847895e-03  5.065207e-03
## ASV0792      3.292049e-03  3.437293e-03  3.588422e-03  3.745630e-03
## ASV0036     -1.026813e-03 -1.075428e-03 -1.126324e-03 -1.179605e-03
## ASV2125      3.174060e-03  3.317900e-03  3.467924e-03  3.624368e-03
## ASV1075     -4.776934e-05 -4.993771e-05 -5.220281e-05 -5.456911e-05
## ASV0390      1.695665e-03  1.775912e-03  1.859933e-03  1.947903e-03
## ASV3790     -2.406315e-03 -2.517544e-03 -2.633762e-03 -2.755179e-03
## ASV1535     -6.954451e-04 -7.300413e-04 -7.664118e-04 -8.046509e-04
## ASV0263      2.946154e-03  3.080716e-03  3.221163e-03  3.367731e-03
## ASV0675      4.429515e-03  4.635918e-03  4.851729e-03  5.077356e-03
## ASV3348      3.594622e-04  3.769822e-04  3.953684e-04  4.146644e-04
## ASV0058     -1.312918e-03 -1.371905e-03 -1.433382e-03 -1.497438e-03
## ASV4142      1.840818e-03  1.921820e-03  2.006076e-03  2.093687e-03
## ASV0059     -1.057456e-03 -1.104668e-03 -1.153845e-03 -1.205055e-03
## ASV0013     -1.880792e-03 -1.966543e-03 -2.056031e-03 -2.149401e-03
## ASV0033     -8.924966e-04 -9.346202e-04 -9.787093e-04 -1.024853e-03
## ASV4354     -1.107946e-03 -1.158544e-03 -1.211365e-03 -1.266498e-03
## ASV0022     -7.536621e-04 -7.892005e-04 -8.263950e-04 -8.653206e-04
## ASV0134     -7.173350e-04 -7.521585e-04 -7.886947e-04 -8.270288e-04
## ASV0415      1.155812e-04  1.218410e-04  1.284587e-04  1.354552e-04
## ASV10103    -4.185376e-03 -4.380488e-03 -4.584500e-03 -4.797799e-03
## ASV1613      3.121078e-03  3.258914e-03  3.402342e-03  3.551542e-03
## ASV0135     -4.009819e-04 -4.181246e-04 -4.359094e-04 -4.543521e-04
## ASV0469     -4.029279e-03 -4.209436e-03 -4.397128e-03 -4.592627e-03
## ASV0471      2.452807e-03  2.564361e-03  2.680749e-03  2.802160e-03
## ASV0451     -4.020577e-04 -4.236393e-04 -4.464585e-04 -4.705908e-04
## ASV0747      1.395997e-03  1.460235e-03  1.527325e-03  1.597381e-03
## ASV1314     -1.402457e-03 -1.469093e-03 -1.538887e-03 -1.611988e-03
## ASV0425     -4.987330e-03 -5.206239e-03 -5.433915e-03 -5.670634e-03
## ASV0559     -1.233957e-03 -1.289816e-03 -1.348085e-03 -1.408859e-03
## ASV0148     -2.791562e-04 -2.896555e-04 -3.004051e-04 -3.113957e-04
## ASV0129      2.888646e-04  3.062468e-04  3.247790e-04  3.445430e-04
## ASV1072      3.308637e-04  3.444894e-04  3.585719e-04  3.731163e-04
## ASV2390      2.555190e-03  2.665381e-03  2.779787e-03  2.898521e-03
## ASV0548      1.687770e-03  1.764319e-03  1.844165e-03  1.927435e-03
## ASV0168     -8.664047e-04 -9.050698e-04 -9.453438e-04 -9.872835e-04
## ASV0066     -9.761051e-04 -1.019987e-03 -1.065722e-03 -1.113376e-03
## ASV0468     -5.170392e-04 -5.407197e-04 -5.654435e-04 -5.912528e-04
## ASV0172     -2.924301e-04 -3.043947e-04 -3.167539e-04 -3.295115e-04
## ASV0236     -5.433021e-05 -5.140058e-05 -4.784595e-05 -4.359654e-05
## ASV0250      1.377144e-03  1.444731e-03  1.515712e-03  1.590261e-03
## ASV0338      6.532307e-04  6.841498e-04  7.165114e-04  7.503798e-04
## ASV0450     -1.223026e-04 -1.290828e-04 -1.362689e-04 -1.438868e-04
## ASV0377      1.219411e-03  1.274082e-03  1.331050e-03  1.390397e-03
## ASV1022     -5.184097e-05 -5.397604e-05 -5.617894e-05 -5.844943e-05
## ASV6174     -2.674879e-05 -2.854469e-05 -3.047683e-05 -3.255650e-05
## ASV0786     -1.701411e-04 -1.801677e-04 -1.908327e-04 -2.021785e-04
## ASV0053     -1.319331e-03 -1.379748e-03 -1.442820e-03 -1.508655e-03
## ASV0697     -8.023062e-04 -8.377183e-04 -8.745700e-04 -9.129092e-04
## ASV0785      1.689154e-03  1.764937e-03  1.843910e-03  1.926186e-03
## ASV1967     -1.678323e-03 -1.753054e-03 -1.830889e-03 -1.911938e-03
## ASV0385      5.650852e-04  5.920920e-04  6.203851e-04  6.500246e-04
## ASV0295      1.001961e-04  1.064390e-04  1.131096e-04  1.202393e-04
## ASV0072     -1.312471e-03 -1.370621e-03 -1.431146e-03 -1.494126e-03
## ASV0157     -1.671307e-04 -1.722417e-04 -1.773408e-04 -1.824056e-04
## ASV0501      2.848775e-03  2.979634e-03  3.116282e-03  3.258954e-03
## ASV10729    -3.580508e-03 -3.745998e-03 -3.918906e-03 -4.099545e-03
## ASV1470      1.824598e-03  1.902825e-03  1.984006e-03  2.068217e-03
## ASV0050     -3.089741e-03 -3.228720e-03 -3.373578e-03 -3.524529e-03
## ASV0411     -6.975267e-04 -7.303287e-04 -7.646522e-04 -8.005656e-04
## ASV0549      1.121168e-03  1.173364e-03  1.227934e-03  1.284980e-03
## ASV0184      3.747267e-04  3.916012e-04  4.091954e-04  4.275368e-04
## ASV0705      7.410482e-04  7.738746e-04  8.080407e-04  8.435907e-04
## ASV1715      1.567921e-03  1.639616e-03  1.714454e-03  1.792559e-03
## ASV0603      2.443942e-04  2.558850e-04  2.679135e-04  2.805048e-04
## ASV0826      2.647066e-03  2.766745e-03  2.891546e-03  3.021666e-03
## ASV0034     -8.477887e-04 -8.854508e-04 -9.246618e-04 -9.654741e-04
## ASV0838      5.841981e-04  6.049806e-04  6.261154e-04  6.475640e-04
## ASV0614     -7.247566e-04 -7.574693e-04 -7.915787e-04 -8.271375e-04
## ASV0014     -1.920725e-03 -2.007850e-03 -2.098729e-03 -2.193506e-03
## ASV0585      2.126767e-04  2.178856e-04  2.229106e-04  2.277075e-04
## ASV0016     -2.006469e-03 -2.097480e-03 -2.192413e-03 -2.291417e-03
## ASV5394     -1.504330e-03 -1.573454e-03 -1.645638e-03 -1.721008e-03
## ASV0666      3.281727e-03  3.426305e-03  3.576726e-03  3.733177e-03
## ASV2085      7.559391e-04  7.828470e-04  8.102404e-04  8.380769e-04
## ASV0003     -1.368194e-03 -1.430197e-03 -1.494867e-03 -1.562305e-03
## ASV0346      6.877613e-04  7.204474e-04  7.546756e-04  7.905165e-04
## ASV0267     -5.803061e-06 -4.587939e-06 -3.182777e-06 -1.567622e-06
## ASV0353      1.093419e-03  1.144651e-03  1.198244e-03  1.254301e-03
## ASV2419      2.945373e-03  3.077798e-03  3.215825e-03  3.359659e-03
## ASV0447      1.603073e-03  1.678420e-03  1.757255e-03  1.839733e-03
## ASV0654      2.375757e-03  2.483714e-03  2.596338e-03  2.713811e-03
## ASV0151      3.167857e-04  3.329556e-04  3.499918e-04  3.679435e-04
## ASV0065     -9.194757e-04 -9.608490e-04 -1.003975e-03 -1.048917e-03
## ASV0527      2.260791e-03  2.363059e-03  2.469708e-03  2.580907e-03
## ASV4055     -3.573135e-04 -3.748230e-04 -3.932146e-04 -4.125351e-04
## ASV0166     -1.136001e-03 -1.186044e-03 -1.238107e-03 -1.292255e-03
## ASV0417     -4.649522e-04 -4.845614e-04 -5.048797e-04 -5.259221e-04
## ASV0078     -6.730939e-04 -7.029654e-04 -7.340610e-04 -7.664219e-04
## ASV0322     -1.233711e-04 -1.275617e-04 -1.317905e-04 -1.360441e-04
## ASV0156     -1.600837e-03 -1.674827e-03 -1.752138e-03 -1.832910e-03
## ASV0648     -3.475943e-03 -3.637386e-03 -3.806138e-03 -3.982513e-03
## ASV0407     -2.605536e-04 -2.729694e-04 -2.859770e-04 -2.996046e-04
## ASV2030     -5.793770e-04 -6.052084e-04 -6.321331e-04 -6.601942e-04
## ASV0300      4.148019e-04  4.345176e-04  4.551655e-04  4.767890e-04
## ASV1150      9.313087e-05  9.796747e-05  1.030678e-04  1.084469e-04
## ASV0958      1.281663e-03  1.342730e-03  1.406706e-03  1.473728e-03
## ASV0216     -1.419393e-03 -1.482881e-03 -1.549035e-03 -1.617952e-03
## ASV0446      2.142042e-03  2.241557e-03  2.345573e-03  2.454285e-03
## ASV0367     -1.403641e-03 -1.468107e-03 -1.535426e-03 -1.605715e-03
## ASV0200     -8.349739e-04 -8.732626e-04 -9.132393e-04 -9.549723e-04
## ASV0334     -4.535170e-04 -4.715699e-04 -4.901764e-04 -5.093383e-04
## ASV1311      5.488682e-04  5.717173e-04  5.953618e-04  6.198149e-04
## ASV0458      8.113225e-04  8.446291e-04  8.790578e-04  9.146241e-04
## ASV1371      1.314925e-04  1.380199e-04  1.448778e-04  1.520828e-04
## ASV0418      1.861076e-03  1.942631e-03  2.027442e-03  2.115612e-03
## ASV0004      2.698145e-04  2.815676e-04  2.937831e-04  3.064749e-04
## ASV1943      5.171555e-03  5.380755e-03  5.596790e-03  5.819745e-03
## ASV1495     -3.722364e-04 -3.933923e-04 -4.158577e-04 -4.397202e-04
## ASV0901     -1.576460e-03 -1.650175e-03 -1.727278e-03 -1.807918e-03
## ASV0628      8.383269e-04  8.741104e-04  9.112276e-04  9.497104e-04
## ASV0400      5.098547e-04  5.323839e-04  5.558262e-04  5.802109e-04
## ASV0116     -4.635945e-04 -4.852218e-04 -5.078377e-04 -5.314856e-04
## ASV0788      4.097782e-03  4.289439e-03  4.489901e-03  4.699560e-03
## ASV0117      3.019078e-04  3.164463e-04  3.316894e-04  3.476713e-04
## ASV3137     -9.593570e-05 -1.001817e-04 -1.046009e-04 -1.091991e-04
## ASV0001      2.897150e-04  3.022612e-04  3.152938e-04  3.288265e-04
## ASV1651      8.254526e-04  8.615604e-04  8.991031e-04  9.381252e-04
## ASV1692      3.412750e-03  3.572067e-03  3.738673e-03  3.912887e-03
## ASV0660      1.218345e-03  1.269748e-03  1.323005e-03  1.378153e-03
## ASV0508      6.112486e-05  6.362945e-05  6.621830e-05  6.889261e-05
## ASV1660     -6.876102e-04 -7.215438e-04 -7.571874e-04 -7.946284e-04
## ASV0233      1.054079e-03  1.102364e-03  1.152776e-03  1.205399e-03
## ASV1343     -1.943594e-03 -2.034047e-03 -2.128614e-03 -2.227475e-03
## ASV0209      9.689220e-04  1.010975e-03  1.054666e-03  1.100044e-03
## ASV0193     -1.131175e-03 -1.180639e-03 -1.232066e-03 -1.285513e-03
## ASV0357      4.340107e-04  4.561251e-04  4.794237e-04  5.039745e-04
## ASV0198      8.589353e-04  8.974031e-04  9.374850e-04  9.792394e-04
## ASV0007      2.557832e-04  2.666859e-04  2.779946e-04  2.897192e-04
## ASV1772     -3.804987e-04 -3.963012e-04 -4.126385e-04 -4.295162e-04
## ASV0009      2.113460e-04  2.201984e-04  2.293653e-04  2.388529e-04
## ASV0006     -2.311664e-04 -2.422401e-04 -2.538456e-04 -2.660086e-04
## ASV0011     -8.015753e-04 -8.387127e-04 -8.775229e-04 -9.180769e-04
## ASV0015      1.597347e-04  1.664195e-04  1.733408e-04  1.805031e-04
## ASV0017      1.799551e-04  1.874976e-04  1.953088e-04  2.033938e-04
## ASV0235     -7.406419e-04 -7.751598e-04 -8.112495e-04 -8.489789e-04
## ASV0382      5.797507e-04  6.067598e-04  6.349910e-04  6.644953e-04
## ASV2357      2.414774e-03  2.526500e-03  2.643249e-03  2.765233e-03
## ASV0567     -4.677749e-04 -4.896116e-04 -5.124521e-04 -5.363419e-04
## ASV0165      4.028855e-04  4.215216e-04  4.409934e-04  4.613360e-04
## ASV0005      5.844966e-04  6.109866e-04  6.386148e-04  6.674248e-04
## ASV0384     -6.352907e-05 -6.513997e-05 -6.670086e-05 -6.819857e-05
## ASV0002      1.093635e-04  1.141705e-04  1.191713e-04  1.243725e-04
## ASV3017      3.095586e-03  3.231200e-03  3.372216e-03  3.518801e-03
## ASV0091     -7.846886e-05 -8.196510e-05 -8.560817e-05 -8.940363e-05
## ASV0186     -1.178153e-03 -1.231844e-03 -1.287869e-03 -1.346320e-03
## ASV0370      6.248481e-04  6.528151e-04  6.819509e-04  7.122970e-04
## ASV0018      7.487874e-04  7.828274e-04  8.183402e-04  8.553826e-04
## ASV1377      7.507272e-03  7.838942e-03  8.184094e-03  8.543174e-03
## ASV0019      7.855467e-04  8.212906e-04  8.585840e-04  8.974874e-04
## ASV0023     -4.911193e-04 -5.140591e-04 -5.380483e-04 -5.631331e-04
## ASV2194      7.894751e-04  8.267565e-04  8.657851e-04  9.066416e-04
## ASV1155      3.140859e-03  3.279223e-03  3.423215e-03  3.573026e-03
## ASV0510     -8.417917e-04 -8.771735e-04 -9.138199e-04 -9.517559e-04
## ASV2371     -1.891384e-03 -1.974761e-03 -2.061525e-03 -2.151792e-03
## ASV0024     -6.115416e-04 -6.400209e-04 -6.697956e-04 -7.009218e-04
## ASV2452      1.900078e-03  1.981325e-03  2.065614e-03  2.153022e-03
## ASV2332     -5.431543e-03 -5.673118e-03 -5.924710e-03 -6.186674e-03
## ASV2591      1.422144e-03  1.493767e-03  1.569088e-03  1.648300e-03
## ASV0521      1.242481e-03  1.300270e-03  1.360682e-03  1.423832e-03
## ASV5542      1.189413e-03  1.244799e-03  1.302691e-03  1.363194e-03
## ASV0336     -1.498512e-04 -1.582792e-04 -1.672179e-04 -1.767002e-04
## ASV10102     2.197535e-03  2.299648e-03  2.406380e-03  2.517928e-03
## ASV16823    -3.393273e-03 -3.539420e-03 -3.691197e-03 -3.848766e-03
## ASV3104      1.755432e-02  1.831024e-02  1.909526e-02  1.991023e-02
## ASV0781      2.450927e-03  2.562142e-03  2.678154e-03  2.799147e-03
## ASV10899     1.438617e-03  1.511405e-03  1.588015e-03  1.668656e-03
## ASV11222    -5.970948e-03 -6.228045e-03 -6.495041e-03 -6.772221e-03
## ASV11327    -5.359878e-03 -5.590620e-03 -5.830243e-03 -6.079001e-03
## ASV12458    -5.968768e-03 -6.225674e-03 -6.492464e-03 -6.769421e-03
## ASV1636      3.372321e-03  3.522168e-03  3.678183e-03  3.840576e-03
## ASV1890     -2.745431e-03 -2.859327e-03 -2.977220e-03 -3.099189e-03
## ASV2898      4.521664e-03  4.722771e-03  4.932181e-03  5.150180e-03
## ASV8328      5.308833e-04  5.668742e-04  6.054906e-04  6.469290e-04
## ASV0709     -5.040518e-03 -5.267731e-03 -5.504586e-03 -5.751439e-03
## ASV0856      4.183806e-03  4.381404e-03  4.588228e-03  4.804697e-03
## ASV0909      1.204769e-03  1.268951e-03  1.336777e-03  1.408466e-03
## ASV0937     -2.962200e-03 -3.099537e-03 -3.243094e-03 -3.393140e-03
## ASV11390    -8.517453e-03 -8.884010e-03 -9.264664e-03 -9.659822e-03
## ASV11966     2.048157e-03  2.146902e-03  2.250423e-03  2.358950e-03
## ASV12990     1.486616e-03  1.552234e-03  1.620500e-03  1.691498e-03
## ASV14797     2.202576e-03  2.298760e-03  2.398748e-03  2.502658e-03
## ASV14904    -1.222180e-02 -1.274776e-02 -1.329395e-02 -1.386094e-02
## ASV15304     1.282114e-03  1.346142e-03  1.413449e-03  1.484207e-03
## ASV16696    -4.222298e-03 -4.403980e-03 -4.592647e-03 -4.788500e-03
## ASV1690      7.109131e-03  7.445843e-03  7.798307e-03  8.167232e-03
## ASV2029      4.955563e-03  5.178044e-03  5.409912e-03  5.651510e-03
## ASV2834      6.206399e-03  6.492548e-03  6.791451e-03  7.103636e-03
## ASV4003      5.094110e-03  5.339976e-03  5.597817e-03  5.868221e-03
## ASV4064      2.944586e-03  3.081313e-03  3.224213e-03  3.373547e-03
## ASV4294      1.774710e-03  1.863234e-03  1.956306e-03  2.054167e-03
## ASV4609      1.676335e-03  1.751303e-03  1.829396e-03  1.910724e-03
## ASV6283     -3.947318e-03 -4.117194e-03 -4.293604e-03 -4.476738e-03
## ASV6491     -5.656702e-03 -5.900096e-03 -6.152850e-03 -6.415232e-03
## ASV7453      2.715710e-03  2.847331e-03  2.985378e-03  3.130162e-03
## ASV7959      9.724051e-04  1.023910e-03  1.078297e-03  1.135737e-03
## ASV8219      4.888174e-02  5.098486e-02  5.316885e-02  5.543602e-02
## ASV8547     -5.063099e-03 -5.280896e-03 -5.507065e-03 -5.741843e-03
## ASV9319      2.194611e-03  2.297924e-03  2.406033e-03  2.519151e-03
## ASV9382     -9.905600e-03 -1.033166e-02 -1.077410e-02 -1.123338e-02
## ASV11516    -6.614941e-03 -6.899412e-03 -7.194811e-03 -7.501449e-03
## ASV14377    -4.775474e-03 -4.980802e-03 -5.194013e-03 -5.415333e-03
## ASV1867      3.684093e-03  3.855102e-03  4.033838e-03  4.220631e-03
## ASV1895      1.858228e-03  1.937767e-03  2.020276e-03  2.105826e-03
## ASV3168      2.336802e-03  2.438880e-03  2.544979e-03  2.655220e-03
## ASV4449      1.284883e-02  1.343074e-02  1.403774e-02  1.467081e-02
## ASV6596      2.663564e-03  2.793769e-03  2.930454e-03  3.073950e-03
## ASV7492     -4.962234e-04 -5.098174e-04 -5.232100e-04 -5.363261e-04
## ASV9854     -1.022010e-03 -1.065251e-03 -1.110099e-03 -1.156597e-03
## ASV6296      8.011740e-02  8.356140e-02  8.713759e-02  9.084972e-02
## ASV4201      3.755662e-04  4.020127e-04  4.304477e-04  4.610232e-04
## ASV0552      2.549790e-03  2.667670e-03  2.790834e-03  2.919503e-03
## ASV3671     -1.702007e-03 -1.778205e-03 -1.857631e-03 -1.940408e-03
## ASV3529     -4.505069e-04 -4.637365e-04 -4.769174e-04 -4.899972e-04
## ASV1060      6.773426e-04  7.095134e-04  7.432101e-04  7.785050e-04
## ASV0239     -9.208525e-04 -9.600277e-04 -1.000658e-03 -1.042778e-03
## ASV5711     -4.161696e-03 -4.346788e-03 -4.539560e-03 -4.740287e-03
## ASV4152     -5.878250e-03 -6.146824e-03 -6.427175e-03 -6.719779e-03
## ASV1461      2.970590e-03  3.097920e-03  3.230060e-03  3.367135e-03
## ASV2877      1.542030e-03  1.608872e-03  1.678307e-03  1.750405e-03
## ASV0012      2.656486e-04  2.777438e-04  2.903652e-04  3.035335e-04
## ASV9823      3.804821e-04  3.948594e-04  4.095823e-04  4.246376e-04
## ASV0008      2.834547e-04  2.962810e-04  3.096582e-04  3.236077e-04
## ASV7832     -3.459819e-03 -3.618648e-03 -3.784531e-03 -3.957764e-03
## ASV1915     -4.399342e-04 -4.591330e-04 -4.791086e-04 -4.998888e-04
## ASV0055     -3.044679e-04 -3.196516e-04 -3.356167e-04 -3.524049e-04
## ASV0032      1.422424e-04  1.478904e-04  1.537095e-04  1.596997e-04
## ASV2977     -4.877933e-03 -5.100019e-03 -5.331772e-03 -5.573573e-03
## ASV0466      3.930341e-03  4.098969e-03  4.273991e-03  4.455575e-03
## ASV3866      2.676863e-03  2.801845e-03  2.932546e-03  3.069216e-03
## ASV0040      9.676739e-04  1.012157e-03  1.058614e-03  1.107124e-03
## ASV0496     -2.257369e-04 -2.403338e-04 -2.559595e-04 -2.726898e-04
## ASV0052      8.123755e-04  8.497711e-04  8.888289e-04  9.296175e-04
## ASV3828     -2.838105e-03 -2.959756e-03 -3.086043e-03 -3.217095e-03
## ASV1930      1.453640e-03  1.517801e-03  1.584555e-03  1.653982e-03
## ASV2126      2.475998e-03  2.587246e-03  2.703193e-03  2.824013e-03
## ASV0793      3.033004e-03  3.174045e-03  3.321484e-03  3.475596e-03
## ASV0299     -5.947131e-05 -6.236647e-05 -6.541469e-05 -6.862591e-05
## ASV0208      2.191243e-03  2.291923e-03  2.397066e-03  2.506854e-03
## ASV0511     -9.048086e-04 -9.431716e-04 -9.829395e-04 -1.024144e-03
## ASV1123     -2.736802e-03 -2.853840e-03 -2.975289e-03 -3.101263e-03
## ASV0099      8.142474e-05  8.566844e-05  9.014950e-05  9.488257e-05
## ASV0752     -1.557461e-03 -1.631456e-03 -1.708945e-03 -1.790089e-03
## ASV0883      2.136775e-03  2.237879e-03  2.343719e-03  2.454512e-03
## ASV0683      2.794702e-03  2.925694e-03  3.062720e-03  3.206046e-03
## ASV4117     -4.456959e-03 -4.661533e-03 -4.875176e-03 -5.098264e-03
## ASV2172      2.912579e-04  3.026958e-04  3.144598e-04  3.265468e-04
## ASV0330     -8.323892e-04 -8.709359e-04 -9.112183e-04 -9.533102e-04
## ASV0728      4.116037e-03  4.303187e-03  4.498431e-03  4.702081e-03
## ASV0499      1.087368e-03  1.138514e-03  1.192033e-03  1.248034e-03
## ASV0120     -1.825399e-03 -1.908573e-03 -1.995361e-03 -2.085904e-03
## ASV1446      1.409531e-03  1.466000e-03  1.524237e-03  1.584252e-03
## ASV17171    -3.527148e-03 -3.687223e-03 -3.854238e-03 -4.028468e-03
## ASV0533      2.616323e-04  2.744451e-04  2.878971e-04  3.020208e-04
## ASV2495     -8.590410e-04 -9.024263e-04 -9.481083e-04 -9.962168e-04
## ASV5582      1.638086e-03  1.705792e-03  1.775817e-03  1.848198e-03
## ASV1488      6.239379e-04  6.513582e-04  6.798745e-04  7.095203e-04
## ASV0682      7.920017e-04  8.294587e-04  8.686714e-04  9.097200e-04
## ASV0068     -1.382137e-03 -1.445396e-03 -1.511430e-03 -1.580349e-03
## ASV1987     -3.433417e-03 -3.597042e-03 -3.768439e-03 -3.947970e-03
## ASV0035     -2.522851e-04 -2.665336e-04 -2.816633e-04 -2.977338e-04
## ASV7192     -2.143489e-03 -2.239022e-03 -2.338528e-03 -2.442147e-03
## ASV0873     -1.870827e-04 -2.458476e-04 -3.115292e-04 -3.847616e-04
## ASV4749     -5.971104e-05 -7.101605e-05 -8.360092e-05 -9.758731e-05
## ASV2174      1.495144e-03  1.557747e-03  1.622569e-03  1.689654e-03
## ASV1476     -1.523082e-03 -1.594929e-03 -1.670143e-03 -1.748880e-03
## ASV0740     -4.325039e-03 -4.528665e-03 -4.741761e-03 -4.964756e-03
## ASV0170     -8.477544e-04 -8.865996e-04 -9.271559e-04 -9.694927e-04
## ASV2466     -3.865049e-03 -4.042204e-03 -4.227186e-03 -4.420316e-03
## ASV1709      1.420560e-03  1.483019e-03  1.548029e-03  1.615681e-03
## ASV6170     -6.046157e-03 -6.327896e-03 -6.622479e-03 -6.930464e-03
## ASV3673      2.967512e-03  3.107172e-03  3.253323e-03  3.406256e-03
## ASV1745     -7.669276e-04 -8.043309e-04 -8.435889e-04 -8.847952e-04
##                                                                    
## (Intercept)  2.462850e-02  2.574882e-02  2.691760e-02  2.813667e-02
## ASV1236      4.847701e-03  5.059458e-03  5.279637e-03  5.508503e-03
## ASV0421      5.660116e-04  5.967619e-04  6.292917e-04  6.637090e-04
## ASV0691     -3.747908e-03 -3.899686e-03 -4.056420e-03 -4.218167e-03
## ASV0899      4.203199e-03  4.387748e-03  4.579680e-03  4.779225e-03
## ASV1004      9.709299e-03  1.013494e-02  1.057760e-02  1.103782e-02
## ASV1041     -3.990819e-03 -4.164702e-03 -4.345402e-03 -4.533117e-03
## ASV1058      6.058952e-03  6.324079e-03  6.599776e-03  6.886379e-03
## ASV12542     2.344361e-03  2.444578e-03  2.548579e-03  2.656465e-03
## ASV1294      5.639597e-03  5.886766e-03  6.143825e-03  6.411090e-03
## ASV13113     1.901313e-03  1.992327e-03  2.087709e-03  2.187668e-03
## ASV1318      5.623123e-03  5.869328e-03  6.125354e-03  6.391512e-03
## ASV2269     -9.733512e-03 -1.015817e-02 -1.059959e-02 -1.105830e-02
## ASV2542      4.771179e-03  4.991843e-03  5.222421e-03  5.463335e-03
## ASV2660     -3.871233e-03 -4.039155e-03 -4.213627e-03 -4.394841e-03
## ASV2737      1.334885e-03  1.390345e-03  1.447758e-03  1.507164e-03
## ASV2840      5.149127e-03  5.366951e-03  5.592746e-03  5.826693e-03
## ASV3053      2.638971e-02  2.752091e-02  2.869509e-02  2.991343e-02
## ASV3077      1.683837e-03  1.756335e-03  1.831623e-03  1.909780e-03
## ASV3134      3.030468e-03  3.173352e-03  3.322905e-03  3.479430e-03
## ASV3140      4.092479e-03  4.278283e-03  4.472108e-03  4.674262e-03
## ASV3579      1.463004e-03  1.534997e-03  1.610608e-03  1.690024e-03
## ASV6119     -2.663432e-03 -2.779607e-03 -2.900368e-03 -3.025854e-03
## ASV7557     -5.411514e-03 -5.647501e-03 -5.892799e-03 -6.147690e-03
## ASV8422      1.346991e-03  1.404849e-03  1.464921e-03  1.527269e-03
## ASV1086     -2.083225e-04 -2.164520e-04 -2.248219e-04 -2.334332e-04
## ASV1310      2.593823e-03  2.707203e-03  2.825085e-03  2.947607e-03
## ASV15750    -3.507708e-04 -3.651426e-04 -3.799930e-04 -3.953279e-04
## ASV16905    -1.112787e-03 -1.161313e-03 -1.211755e-03 -1.264168e-03
## ASV2033      4.795837e-03  5.019868e-03  5.254139e-03  5.499095e-03
## ASV2089      2.346780e-03  2.449230e-03  2.555731e-03  2.666409e-03
## ASV2127      7.623605e-03  7.956917e-03  8.303484e-03  8.663721e-03
## ASV2725      6.088676e-03  6.350751e-03  6.622872e-03  6.905319e-03
## ASV2804     -2.303378e-03 -2.403814e-03 -2.508213e-03 -2.616694e-03
## ASV3075      5.070453e-03  5.298734e-03  5.536754e-03  5.784885e-03
## ASV3327      7.034458e-03  7.358748e-03  7.697491e-03  8.051286e-03
## ASV3342      6.040628e-03  6.317305e-03  6.606163e-03  6.907697e-03
## ASV3532     -6.655219e-03 -6.956621e-03 -7.270998e-03 -7.598855e-03
## ASV3600      3.095322e-03  3.236151e-03  3.383099e-03  3.536410e-03
## ASV4013      5.757143e-03  6.013358e-03  6.280174e-03  6.557961e-03
## ASV4136      6.115148e-03  6.379159e-03  6.653392e-03  6.938145e-03
## ASV4195      2.350794e-02  2.453272e-02  2.559790e-02  2.670471e-02
## ASV4407     -9.081066e-03 -9.476842e-03 -9.888215e-03 -1.031566e-02
## ASV4717      1.568599e-03  1.632964e-03  1.699518e-03  1.768295e-03
## ASV6794      3.750688e-03  3.909971e-03  4.075190e-03  4.246499e-03
## ASV8324     -4.659731e-03 -4.862815e-03 -5.073902e-03 -5.293233e-03
## ASV8981     -1.071283e-04 -1.090884e-04 -1.108679e-04 -1.124358e-04
## ASV9859      1.649139e-03  1.731640e-03  1.818418e-03  1.909703e-03
## ASV0936      4.555090e-03  4.763930e-03  4.981962e-03  5.209553e-03
## ASV12683    -7.875406e-06 -9.096410e-06 -1.044016e-05 -1.191636e-05
## ASV1293      3.021961e-03  3.153419e-03  3.290043e-03  3.431987e-03
## ASV13055    -6.521102e-05 -6.606986e-05 -6.677384e-05 -6.729971e-05
## ASV17063    -2.416195e-03 -2.521413e-03 -2.630770e-03 -2.744391e-03
## ASV2228      1.970094e-03  2.055865e-03  2.145009e-03  2.237627e-03
## ASV2769      3.197237e-04  3.366492e-04  3.545168e-04  3.733806e-04
## ASV2803      2.122003e-03  2.211265e-03  2.303760e-03  2.399561e-03
## ASV2896      1.720505e-03  1.800131e-03  1.883352e-03  1.970326e-03
## ASV3062      2.091329e-03  2.192485e-03  2.298575e-03  2.409839e-03
## ASV3107      3.202307e-03  3.349175e-03  3.502536e-03  3.662656e-03
## ASV3265      4.322034e-03  4.509544e-03  4.704369e-03  4.906725e-03
## ASV3666      4.084489e-05  4.228764e-05  4.375126e-05  4.523237e-05
## ASV4497      1.487738e-03  1.553162e-03  1.621222e-03  1.692004e-03
## ASV6914     -2.285111e-04 -2.403656e-04 -2.528655e-04 -2.660477e-04
## ASV0576     -5.129550e-03 -5.343394e-03 -5.564807e-03 -5.793945e-03
## ASV0673      5.736824e-03  5.991127e-03  6.255856e-03  6.531365e-03
## ASV0772      2.666173e-03  2.785365e-03  2.909548e-03  3.038901e-03
## ASV0862      2.824263e-04  3.025515e-04  3.241931e-04  3.474651e-04
## ASV0898      2.087821e-03  2.186035e-03  2.288792e-03  2.396293e-03
## ASV0910      2.402434e-03  2.513233e-03  2.628981e-03  2.749886e-03
## ASV0964     -1.943246e-03 -2.025379e-03 -2.110515e-03 -2.198725e-03
## ASV10059     1.718415e-03  1.800276e-03  1.886025e-03  1.975844e-03
## ASV10263    -3.681997e-03 -3.842558e-03 -4.009457e-03 -4.182886e-03
## ASV1088      4.277384e-03  4.472862e-03  4.676938e-03  4.889965e-03
## ASV1101      5.261342e-03  5.490040e-03  5.727698e-03  5.974580e-03
## ASV1183      1.399908e-03  1.463269e-03  1.529353e-03  1.598264e-03
## ASV11956     1.337753e-03  1.393276e-03  1.450744e-03  1.510195e-03
## ASV12774     7.000927e-05  7.075237e-05  7.130832e-05  7.165076e-05
## ASV1321      6.210581e-03  6.499294e-03  6.801103e-03  7.116572e-03
## ASV13793    -2.538552e-03 -2.649236e-03 -2.764288e-03 -2.883840e-03
## ASV14482     1.589158e-04  1.650457e-04  1.713553e-04  1.778461e-04
## ASV15483     1.053046e-03  1.101469e-03  1.152038e-03  1.204841e-03
## ASV2062      4.880783e-03  5.097520e-03  5.323196e-03  5.558123e-03
## ASV2132      4.005071e-03  4.188681e-03  4.380382e-03  4.580503e-03
## ASV2413      3.765574e-03  3.930426e-03  4.101866e-03  4.280105e-03
## ASV2490      1.155041e-02  1.204394e-02  1.255606e-02  1.308727e-02
## ASV2594      1.457219e-03  1.523377e-03  1.592413e-03  1.664443e-03
## ASV2822     -6.700644e-03 -6.992967e-03 -7.296841e-03 -7.612617e-03
## ASV2863      7.118339e-03  7.425773e-03  7.745118e-03  8.076720e-03
## ASV2910      2.607916e-03  2.721437e-03  2.839429e-03  2.962025e-03
## ASV2980      2.920171e-03  3.050220e-03  3.185661e-03  3.326681e-03
## ASV3307      5.330179e-03  5.562603e-03  5.804202e-03  6.055254e-03
## ASV3474      3.561860e-03  3.729081e-03  3.904026e-03  4.087041e-03
## ASV3502      3.717733e-03  3.885402e-03  4.060219e-03  4.242454e-03
## ASV4236      5.425403e-03  5.655641e-03  5.894387e-03  6.141846e-03
## ASV4842     -5.918603e-04 -6.195099e-04 -6.483925e-04 -6.785548e-04
## ASV4894     -2.539465e-03 -2.650242e-03 -2.765395e-03 -2.885058e-03
## ASV5290      2.031246e-03  2.124020e-03  2.220849e-03  2.321892e-03
## ASV5501      1.239518e-03  1.295466e-03  1.353820e-03  1.414677e-03
## ASV5795      1.365600e-03  1.428175e-03  1.493505e-03  1.561700e-03
## ASV5987     -7.093840e-03 -7.403363e-03 -7.725124e-03 -8.059496e-03
## ASV6267     -7.992043e-03 -8.340675e-03 -8.703084e-03 -9.079689e-03
## ASV6862      3.199379e-03  3.336259e-03  3.478323e-03  3.625711e-03
## ASV7145      1.409056e-03  1.468299e-03  1.529711e-03  1.593349e-03
## ASV7673     -2.539278e-03 -2.650042e-03 -2.765181e-03 -2.884830e-03
## ASV7789      1.283160e-03  1.346762e-03  1.413603e-03  1.483853e-03
## ASV7809      9.491623e-05  1.019412e-04  1.095108e-04  1.176667e-04
## ASV8002     -3.206948e-03 -3.346836e-03 -3.492253e-03 -3.643366e-03
## ASV8205      1.351171e-03  1.412653e-03  1.476809e-03  1.543745e-03
## ASV9155     -8.128017e-04 -8.474458e-04 -8.833823e-04 -9.206433e-04
## ASV9221      3.455207e-04  3.657211e-04  3.872047e-04  4.100582e-04
## ASV9311     -5.144148e-03 -5.368518e-03 -5.601754e-03 -5.844126e-03
## ASV9557     -3.515071e-03 -3.668350e-03 -3.827683e-03 -3.993253e-03
## ASV9936     -7.087473e-03 -7.396459e-03 -7.717641e-03 -8.051391e-03
## ASV1445      4.332640e-03  4.529928e-03  4.735794e-03  4.950574e-03
## ASV4232      1.649984e-03  1.728657e-03  1.811090e-03  1.897464e-03
## ASV6479      6.027692e-04  6.363231e-04  6.718862e-04  7.095861e-04
## ASV0142     -3.052679e-03 -3.184822e-03 -3.322103e-03 -3.464672e-03
## ASV0378      1.405521e-03  1.472508e-03  1.542676e-03  1.616176e-03
## ASV1122      4.197494e-03  4.389968e-03  4.590931e-03  4.800730e-03
## ASV0123     -2.695039e-03 -2.811461e-03 -2.932387e-03 -3.057947e-03
## ASV2064      1.370997e-03  1.427478e-03  1.485879e-03  1.546228e-03
## ASV4459     -1.895903e-04 -1.966246e-04 -2.038307e-04 -2.112051e-04
## ASV0448      1.124130e-03  1.177775e-03  1.233973e-03  1.292843e-03
## ASV0397      2.460377e-03  2.570675e-03  2.685612e-03  2.805356e-03
## ASV0485      2.854432e-03  2.980676e-03  3.112083e-03  3.248825e-03
## ASV1566      4.210818e-03  4.399044e-03  4.595134e-03  4.799369e-03
## ASV1365      3.601705e-03  3.764668e-03  3.934609e-03  4.111791e-03
## ASV1065      5.117072e-03  5.348087e-03  5.588967e-03  5.840083e-03
## ASV0722     -2.685163e-04 -2.811439e-04 -2.943625e-04 -3.081999e-04
## ASV12660    -2.919195e-03 -3.044763e-03 -3.175154e-03 -3.310503e-03
## ASV0223      7.889835e-04  8.240435e-04  8.605551e-04  8.985699e-04
## ASV0229      1.209202e-03  1.264791e-03  1.322849e-03  1.383478e-03
## ASV0877      4.998778e-04  5.201422e-04  5.410432e-04  5.625815e-04
## ASV0983      2.831195e-03  2.955643e-03  3.085099e-03  3.219726e-03
## ASV0626      3.199129e-04  3.391276e-04  3.595830e-04  3.813616e-04
## ASV4146      1.389973e-04  1.449599e-04  1.511276e-04  1.575004e-04
## ASV4175     -3.506857e-03 -3.667199e-03 -3.834569e-03 -4.009248e-03
## ASV2082     -1.604735e-03 -1.687688e-03 -1.775162e-03 -1.867418e-03
## ASV2272      1.668760e-03  1.744682e-03  1.823909e-03  1.906574e-03
## ASV2245     -2.506354e-03 -2.621604e-03 -2.741960e-03 -2.867632e-03
## ASV0590     -1.520789e-03 -1.602053e-03 -1.687939e-03 -1.778726e-03
## ASV0217      1.493256e-04  1.629785e-04  1.778319e-04  1.939847e-04
## ASV0416      1.876129e-03  1.952469e-03  2.031318e-03  2.112705e-03
## ASV1056      2.428361e-03  2.541726e-03  2.660264e-03  2.784200e-03
## ASV7777     -3.410658e-03 -3.565715e-03 -3.727504e-03 -3.896291e-03
## ASV0455      6.114476e-04  6.389965e-04  6.677149e-04  6.976461e-04
## ASV0604      1.601301e-03  1.677015e-03  1.756265e-03  1.839214e-03
## ASV6100     -2.354090e-03 -2.462559e-03 -2.575869e-03 -2.694224e-03
## ASV11359    -5.052142e-03 -5.281811e-03 -5.521423e-03 -5.771365e-03
## ASV6604      7.037354e-04  7.368454e-04  7.714894e-04  8.077358e-04
## ASV5004     -1.795191e-03 -1.876159e-03 -1.960585e-03 -2.048599e-03
## ASV1483     -7.725579e-04 -8.071375e-04 -8.431662e-04 -8.806962e-04
## ASV9773     -2.277486e-03 -2.381652e-03 -2.490393e-03 -2.603897e-03
## ASV4059      1.960729e-05  2.573544e-05  3.259881e-05  4.026708e-05
## ASV1193      2.745326e-03  2.868580e-03  2.997034e-03  3.130879e-03
## ASV4610     -4.120552e-04 -4.234453e-04 -4.347053e-04 -4.457804e-04
## ASV0742     -2.434533e-04 -2.484189e-04 -2.530639e-04 -2.573308e-04
## ASV1502     -1.346774e-04 -1.445377e-04 -1.551581e-04 -1.665969e-04
## ASV0195      5.977122e-05  6.016418e-05  6.037293e-05  6.037362e-05
## ASV1213      1.917678e-03  1.997963e-03  2.081119e-03  2.167205e-03
## ASV1648     -2.113731e-03 -2.210940e-03 -2.312475e-03 -2.418518e-03
## ASV6984     -1.977957e-03 -2.069034e-03 -2.164177e-03 -2.263558e-03
## ASV0396     -1.042067e-04 -1.063535e-04 -1.083731e-04 -1.102434e-04
## ASV4297      2.788546e-03  2.907707e-03  3.031352e-03  3.159597e-03
## ASV2622      4.337965e-03  4.527681e-03  4.724954e-03  4.930021e-03
## ASV3512      1.718619e-03  1.803906e-03  1.893553e-03  1.987790e-03
## ASV2411      2.983105e-03  3.122861e-03  3.269048e-03  3.421953e-03
## ASV2291     -1.317987e-03 -1.389586e-03 -1.465338e-03 -1.545495e-03
## ASV0807      4.043752e-03  4.225396e-03  4.414708e-03  4.611965e-03
## ASV1292      9.644133e-04  1.003681e-03  1.044248e-03  1.086132e-03
## ASV1035      3.690333e-03  3.850128e-03  4.016164e-03  4.188631e-03
## ASV0070      3.964639e-05  4.395548e-05  4.868013e-05  5.385708e-05
## ASV0255      3.472124e-04  3.614036e-04  3.760601e-04  3.911860e-04
## ASV0057     -1.011244e-03 -1.053634e-03 -1.097539e-03 -1.142991e-03
## ASV0077     -2.116057e-04 -2.195172e-04 -2.276186e-04 -2.359041e-04
## ASV0625      2.122329e-03  2.213331e-03  2.307788e-03  2.405795e-03
## ASV2464      1.443152e-02  1.504751e-02  1.568676e-02  1.634991e-02
## ASV1315      3.889664e-03  4.072858e-03  4.264568e-03  4.465175e-03
## ASV2673      3.337253e-03  3.494687e-03  3.659462e-03  3.831911e-03
## ASV2161      1.410586e-03  1.476912e-03  1.546319e-03  1.618945e-03
## ASV0337     -8.046543e-04 -8.415529e-04 -8.800781e-04 -9.202959e-04
## ASV7680     -5.254172e-03 -5.495973e-03 -5.748521e-03 -6.012261e-03
## ASV0611      2.935290e-03  3.070630e-03  3.212014e-03  3.359696e-03
## ASV3118     -3.061192e-03 -3.206383e-03 -3.358406e-03 -3.517577e-03
## ASV1284      1.030154e-03  1.059999e-03  1.089604e-03  1.118824e-03
## ASV0889      2.205050e-03  2.302217e-03  2.403330e-03  2.508523e-03
## ASV4649     -1.109463e-03 -1.159728e-03 -1.212157e-03 -1.266836e-03
## ASV1108     -2.295697e-03 -2.406208e-03 -2.522071e-03 -2.643548e-03
## ASV0738      1.280950e-03  1.346314e-03  1.415160e-03  1.487685e-03
## ASV0473     -2.651361e-04 -2.800775e-04 -2.959107e-04 -3.126899e-04
## ASV0598     -6.590845e-04 -6.940708e-04 -7.310376e-04 -7.701046e-04
## ASV0429      1.632015e-03  1.702576e-03  1.775861e-03  1.851945e-03
## ASV1549      3.080048e-03  3.225588e-03  3.377936e-03  3.537402e-03
## ASV1203      2.399680e-03  2.505866e-03  2.616390e-03  2.731399e-03
## ASV4532      9.929740e-05  1.025958e-04  1.059382e-04  1.093192e-04
## ASV0274      4.259049e-04  4.469198e-04  4.689867e-04  4.921576e-04
## ASV0163     -1.842743e-03 -1.921425e-03 -2.003073e-03 -2.087765e-03
## ASV1298      1.977941e-04  2.052133e-04  2.128308e-04  2.206462e-04
## ASV9424     -4.076926e-03 -4.265623e-03 -4.462818e-03 -4.668873e-03
## ASV0412      4.158391e-03  4.341116e-03  4.531203e-03  4.728892e-03
## ASV0284      8.552340e-04  8.889708e-04  9.237111e-04  9.594541e-04
## ASV0620     -8.763151e-04 -9.210498e-04 -9.681633e-04 -1.017787e-03
## ASV0153     -4.117625e-03 -4.312097e-03 -4.515650e-03 -4.728695e-03
## ASV0498      1.446453e-03  1.513064e-03  1.582627e-03  1.655259e-03
## ASV0097      8.088477e-04  8.470415e-04  8.870210e-04  9.288679e-04
## ASV0104     -5.662063e-03 -5.915034e-03 -6.178554e-03 -6.452999e-03
## ASV1282      1.940274e-03  2.023714e-03  2.110325e-03  2.200192e-03
## ASV3883     -1.580168e-03 -1.657692e-03 -1.739078e-03 -1.824520e-03
## ASV0801      7.712643e-04  8.067400e-04  8.437880e-04  8.824728e-04
## ASV1611     -3.661635e-03 -3.832816e-03 -4.011849e-03 -4.199078e-03
## ASV0227     -6.774930e-04 -7.133315e-04 -7.511707e-04 -7.911275e-04
## ASV0833      1.240432e-03  1.297216e-03  1.356490e-03  1.418354e-03
## ASV0718      5.544694e-03  5.797399e-03  6.061123e-03  6.336304e-03
## ASV1139      6.888693e-04  7.135742e-04  7.387494e-04  7.643600e-04
## ASV0766     -7.862653e-04 -8.249595e-04 -8.655881e-04 -9.082480e-04
## ASV2091      4.457923e-03  4.649292e-03  4.847940e-03  5.054065e-03
## ASV1238     -4.136346e-03 -4.328263e-03 -4.528883e-03 -4.738586e-03
## ASV9193     -4.180027e-04 -4.427517e-04 -4.691041e-04 -4.971712e-04
## ASV0290      5.716828e-04  5.937122e-04  6.163547e-04  6.396066e-04
## ASV0231      1.636817e-03  1.708699e-03  1.783468e-03  1.861217e-03
## ASV0185      9.819876e-04  1.031880e-03  1.084414e-03  1.139738e-03
## ASV2330      1.862944e-03  1.941495e-03  2.022902e-03  2.107232e-03
## ASV3119     -8.879454e-04 -9.327419e-04 -9.798817e-04 -1.029492e-03
## ASV2368     -2.131659e-03 -2.232703e-03 -2.338521e-03 -2.449336e-03
## ASV0122     -1.019286e-03 -1.064541e-03 -1.111662e-03 -1.160714e-03
## ASV1044      2.638428e-03  2.761835e-03  2.890908e-03  3.025899e-03
## ASV0160     -1.084981e-03 -1.130858e-03 -1.178419e-03 -1.227704e-03
## ASV0326      2.909920e-04  3.043385e-04  3.182699e-04  3.328090e-04
## ASV1388      5.291646e-03  5.527539e-03  5.773225e-03  6.029045e-03
## ASV0792      3.909109e-03  4.079058e-03  4.255674e-03  4.439158e-03
## ASV0036     -1.235380e-03 -1.293763e-03 -1.354873e-03 -1.418831e-03
## ASV2125      3.787474e-03  3.957490e-03  4.134673e-03  4.319282e-03
## ASV1075     -5.704134e-05 -5.962452e-05 -6.232401e-05 -6.514547e-05
## ASV0390      2.040005e-03  2.136432e-03  2.237383e-03  2.343067e-03
## ASV3790     -2.882013e-03 -3.014490e-03 -3.152844e-03 -3.297316e-03
## ASV1535     -8.448580e-04 -8.871381e-04 -9.316017e-04 -9.783651e-04
## ASV0263      3.520663e-03  3.680206e-03  3.846619e-03  4.020166e-03
## ASV0675      5.313224e-03  5.559777e-03  5.817472e-03  6.086788e-03
## ASV3348      4.349156e-04  4.561697e-04  4.784769e-04  5.018897e-04
## ASV0058     -1.564166e-03 -1.633661e-03 -1.706020e-03 -1.781340e-03
## ASV4142      2.184757e-03  2.279390e-03  2.377690e-03  2.479760e-03
## ASV0059     -1.258368e-03 -1.313856e-03 -1.371591e-03 -1.431647e-03
## ASV0013     -2.246807e-03 -2.348404e-03 -2.454353e-03 -2.564820e-03
## ASV0033     -1.073144e-03 -1.123680e-03 -1.176560e-03 -1.231891e-03
## ASV4354     -1.324037e-03 -1.384081e-03 -1.446729e-03 -1.512085e-03
## ASV0022     -9.060553e-04 -9.486807e-04 -9.932816e-04 -1.039946e-03
## ASV0134     -8.672507e-04 -9.094546e-04 -9.537392e-04 -1.000208e-03
## ASV0415      1.428527e-04  1.506746e-04  1.589453e-04  1.676908e-04
## ASV10103    -5.020789e-03 -5.253888e-03 -5.497532e-03 -5.752172e-03
## ASV1613      3.706701e-03  3.868003e-03  4.035636e-03  4.209788e-03
## ASV0135     -4.734680e-04 -4.932723e-04 -5.137792e-04 -5.350027e-04
## ASV0469     -4.796209e-03 -5.008156e-03 -5.228759e-03 -5.458312e-03
## ASV0471      2.928787e-03  3.060830e-03  3.198495e-03  3.341991e-03
## ASV0451     -4.961164e-04 -5.231206e-04 -5.516940e-04 -5.819326e-04
## ASV0747      1.670526e-03  1.746884e-03  1.826584e-03  1.909759e-03
## ASV1314     -1.688551e-03 -1.768740e-03 -1.852724e-03 -1.940681e-03
## ASV0425     -5.916677e-03 -6.172324e-03 -6.437858e-03 -6.713562e-03
## ASV0559     -1.472237e-03 -1.538321e-03 -1.607214e-03 -1.679026e-03
## ASV0148     -3.226159e-04 -3.340523e-04 -3.456887e-04 -3.575063e-04
## ASV0129      3.656265e-04  3.881235e-04  4.121349e-04  4.377687e-04
## ASV1072      3.881269e-04  4.036064e-04  4.195564e-04  4.359770e-04
## ASV2390      3.021692e-03  3.149409e-03  3.281778e-03  3.418902e-03
## ASV0548      2.014259e-03  2.104769e-03  2.199103e-03  2.297401e-03
## ASV0168     -1.030947e-03 -1.076393e-03 -1.123682e-03 -1.172876e-03
## ASV0066     -1.163019e-03 -1.214721e-03 -1.268553e-03 -1.324588e-03
## ASV0468     -6.181918e-04 -6.463056e-04 -6.756412e-04 -7.062470e-04
## ASV0172     -3.426704e-04 -3.562326e-04 -3.701987e-04 -3.845681e-04
## ASV0236     -3.857634e-05 -3.270265e-05 -2.588559e-05 -1.802761e-05
## ASV0250      1.668565e-03  1.750818e-03  1.837225e-03  1.928002e-03
## ASV0338      7.858218e-04  8.229064e-04  8.617054e-04  9.022930e-04
## ASV0450     -1.519644e-04 -1.605311e-04 -1.696186e-04 -1.792604e-04
## ASV0377      1.452208e-03  1.516570e-03  1.583569e-03  1.653297e-03
## ASV1022     -6.078692e-05 -6.319042e-05 -6.565844e-05 -6.818899e-05
## ASV6174     -3.479594e-05 -3.720843e-05 -3.980840e-05 -4.261146e-05
## ASV0786     -2.142503e-04 -2.270964e-04 -2.407679e-04 -2.553192e-04
## ASV0053     -1.577362e-03 -1.649055e-03 -1.723851e-03 -1.801870e-03
## ASV0697     -9.527847e-04 -9.942458e-04 -1.037343e-03 -1.082126e-03
## ASV0785      2.011884e-03  2.101125e-03  2.194032e-03  2.290729e-03
## ASV1967     -1.996313e-03 -2.084130e-03 -2.175506e-03 -2.270561e-03
## ASV0385      6.810732e-04  7.135960e-04  7.476611e-04  7.833392e-04
## ASV0295      1.278615e-04  1.360124e-04  1.447305e-04  1.540575e-04
## ASV0072     -1.559639e-03 -1.627767e-03 -1.698591e-03 -1.772193e-03
## ASV0157     -1.874109e-04 -1.923286e-04 -1.971273e-04 -2.017721e-04
## ASV0501      3.407895e-03  3.563356e-03  3.725596e-03  3.894883e-03
## ASV10729    -4.288238e-03 -4.485319e-03 -4.691135e-03 -4.906046e-03
## ASV1470      2.155532e-03  2.246024e-03  2.339762e-03  2.436816e-03
## ASV0050     -3.681794e-03 -3.845598e-03 -4.016171e-03 -4.193747e-03
## ASV0411     -8.381403e-04 -8.774507e-04 -9.185743e-04 -9.615918e-04
## ASV0549      1.344608e-03  1.406929e-03  1.472058e-03  1.540114e-03
## ASV0184      4.466538e-04  4.665758e-04  4.873327e-04  5.089557e-04
## ASV0705      8.805695e-04  9.190222e-04  9.589944e-04  1.000532e-03
## ASV1715      1.874062e-03  1.959095e-03  2.047796e-03  2.140308e-03
## ASV0603      2.936857e-04  3.074840e-04  3.219290e-04  3.370516e-04
## ASV0826      3.157303e-03  3.298661e-03  3.445951e-03  3.599388e-03
## ASV0034     -1.007941e-03 -1.052117e-03 -1.098057e-03 -1.145816e-03
## ASV0838      6.692816e-04  6.912164e-04  7.133092e-04  7.354922e-04
## ASV0614     -8.641999e-04 -9.028213e-04 -9.430589e-04 -9.849709e-04
## ASV0014     -2.292329e-03 -2.395351e-03 -2.502727e-03 -2.614618e-03
## ASV0585      2.322274e-04  2.364161e-04  2.402143e-04  2.435567e-04
## ASV0016     -2.394647e-03 -2.502263e-03 -2.614428e-03 -2.731308e-03
## ASV5394     -1.799693e-03 -1.881825e-03 -1.967544e-03 -2.056991e-03
## ASV0666      3.895852e-03  4.064944e-03  4.240648e-03  4.423161e-03
## ASV2085      8.663080e-04  8.948774e-04  9.237211e-04  9.527666e-04
## ASV0003     -1.632617e-03 -1.705908e-03 -1.782291e-03 -1.861877e-03
## ASV0346      8.280442e-04  8.673356e-04  9.084707e-04  9.515328e-04
## ASV0267      2.792057e-07  2.381225e-06  4.763913e-06  7.454834e-06
## ASV0353      1.312932e-03  1.374249e-03  1.438372e-03  1.505422e-03
## ASV2419      3.509510e-03  3.665595e-03  3.828135e-03  3.997354e-03
## ASV0447      1.926016e-03  2.016274e-03  2.110681e-03  2.209420e-03
## ASV0654      2.836316e-03  2.964046e-03  3.097195e-03  3.235964e-03
## ASV0151      3.868629e-04  4.068053e-04  4.278292e-04  4.499966e-04
## ASV0065     -1.095742e-03 -1.144517e-03 -1.195312e-03 -1.248197e-03
## ASV0527      2.696825e-03  2.817638e-03  2.943526e-03  3.074673e-03
## ASV4055     -4.328337e-04 -4.541628e-04 -4.765776e-04 -5.001366e-04
## ASV0166     -1.348556e-03 -1.407075e-03 -1.467881e-03 -1.531040e-03
## ASV0417     -5.477027e-04 -5.702350e-04 -5.935313e-04 -6.176029e-04
## ASV0078     -8.000895e-04 -8.351057e-04 -8.715130e-04 -9.093538e-04
## ASV0322     -1.403070e-04 -1.445613e-04 -1.487868e-04 -1.529605e-04
## ASV0156     -1.917290e-03 -2.005427e-03 -2.097479e-03 -2.193608e-03
## ASV0648     -4.166836e-03 -4.359445e-03 -4.560692e-03 -4.770939e-03
## ASV0407     -3.138817e-04 -3.288393e-04 -3.445099e-04 -3.609273e-04
## ASV2030     -6.894368e-04 -7.199074e-04 -7.516547e-04 -7.847296e-04
## ASV0300      4.994333e-04  5.231456e-04  5.479751e-04  5.739732e-04
## ASV1150      1.141205e-04  1.201056e-04  1.264198e-04  1.330817e-04
## ASV0958      1.543940e-03  1.617494e-03  1.694547e-03  1.775266e-03
## ASV0216     -1.689731e-03 -1.764477e-03 -1.842294e-03 -1.923291e-03
## ASV0446      2.567890e-03  2.686596e-03  2.810617e-03  2.940175e-03
## ASV0367     -1.679094e-03 -1.755689e-03 -1.835628e-03 -1.919044e-03
## ASV0200     -9.985323e-04 -1.043992e-03 -1.091427e-03 -1.140914e-03
## ASV0334     -5.290560e-04 -5.493282e-04 -5.701517e-04 -5.915212e-04
## ASV1311      6.450884e-04  6.711928e-04  6.981368e-04  7.259273e-04
## ASV0458      9.513419e-04  9.892225e-04  1.028275e-03  1.068505e-03
## ASV1371      1.596526e-04  1.676056e-04  1.759609e-04  1.847388e-04
## ASV0418      2.207246e-03  2.302447e-03  2.401320e-03  2.503969e-03
## ASV0004      3.196569e-04  3.333429e-04  3.475469e-04  3.622827e-04
## ASV1943      6.049691e-03  6.286690e-03  6.530786e-03  6.782010e-03
## ASV1495     -4.650732e-04 -4.920163e-04 -5.206563e-04 -5.511070e-04
## ASV0901     -1.892253e-03 -1.980446e-03 -2.072666e-03 -2.169090e-03
## ASV0628      9.895899e-04  1.030896e-03  1.073657e-03  1.117901e-03
## ASV0400      6.055676e-04  6.319262e-04  6.593163e-04  6.877680e-04
## ASV0116     -5.562107e-04 -5.820600e-04 -6.090824e-04 -6.373285e-04
## ASV0788      4.918821e-03  5.148109e-03  5.387863e-03  5.638542e-03
## ASV0117      3.644281e-04  3.819971e-04  4.004180e-04  4.197318e-04
## ASV3137     -1.139822e-04 -1.189561e-04 -1.241266e-04 -1.294998e-04
## ASV0001      3.428730e-04  3.574470e-04  3.725621e-04  3.882314e-04
## ASV1651      9.786714e-04  1.020787e-03  1.064516e-03  1.109904e-03
## ASV1692      4.095043e-03  4.285486e-03  4.484575e-03  4.692686e-03
## ASV0660      1.435226e-03  1.494258e-03  1.555278e-03  1.618312e-03
## ASV0508      7.165346e-05  7.450177e-05  7.743829e-05  8.046357e-05
## ASV1660     -8.339589e-04 -8.752755e-04 -9.186796e-04 -9.642774e-04
## ASV0233      1.260323e-03  1.317640e-03  1.377443e-03  1.439832e-03
## ASV1343     -2.330814e-03 -2.438825e-03 -2.551709e-03 -2.669673e-03
## ASV0209      1.147155e-03  1.196046e-03  1.246765e-03  1.299357e-03
## ASV0193     -1.341040e-03 -1.398709e-03 -1.458577e-03 -1.520706e-03
## ASV0357      5.298493e-04  5.571243e-04  5.858807e-04  6.162044e-04
## ASV0198      1.022726e-03  1.068006e-03  1.115141e-03  1.164196e-03
## ASV0007      3.018693e-04  3.144542e-04  3.274828e-04  3.409638e-04
## ASV1772     -4.469381e-04 -4.649062e-04 -4.834208e-04 -5.024797e-04
## ASV0009      2.486668e-04  2.588124e-04  2.692944e-04  2.801170e-04
## ASV0006     -2.787556e-04 -2.921146e-04 -3.061149e-04 -3.207870e-04
## ASV0011     -9.604485e-04 -1.004714e-03 -1.050953e-03 -1.099246e-03
## ASV0015      1.879104e-04  1.955666e-04  2.034750e-04  2.116385e-04
## ASV0017      2.117577e-04  2.204050e-04  2.293399e-04  2.385663e-04
## ASV0235     -8.884187e-04 -9.296423e-04 -9.727257e-04 -1.017748e-03
## ASV0382      6.953256e-04  7.275363e-04  7.611835e-04  7.963248e-04
## ASV2357      2.892673e-03  3.025798e-03  3.164846e-03  3.310062e-03
## ASV0567     -5.613279e-04 -5.874597e-04 -6.147886e-04 -6.433687e-04
## ASV0165      4.825857e-04  5.047798e-04  5.279573e-04  5.521582e-04
## ASV0005      6.974609e-04  7.287689e-04  7.613953e-04  7.953881e-04
## ASV0384     -6.961844e-05 -7.094424e-05 -7.215799e-05 -7.323983e-05
## ASV0002      1.297805e-04  1.354019e-04  1.412434e-04  1.473116e-04
## ASV3017      3.671123e-03  3.829352e-03  3.993656e-03  4.164205e-03
## ASV0091     -9.335730e-05 -9.747515e-05 -1.017634e-04 -1.062285e-04
## ASV0186     -1.407290e-03 -1.470876e-03 -1.537177e-03 -1.606294e-03
## ASV0370      7.438956e-04  7.767898e-04  8.110233e-04  8.466406e-04
## ASV0018      8.940133e-04  9.342925e-04  9.762820e-04  1.020045e-03
## ASV1377      8.916632e-03  9.304926e-03  9.708515e-03  1.012786e-02
## ASV0019      9.380626e-04  9.803734e-04  1.024485e-03  1.070466e-03
## ASV0023     -5.893609e-04 -6.167814e-04 -6.454461e-04 -6.754082e-04
## ASV2194      9.494106e-04  9.941803e-04  1.041043e-03  1.090094e-03
## ASV1155      3.728852e-03  3.890892e-03  4.059347e-03  4.234424e-03
## ASV0510     -9.910050e-04 -1.031589e-03 -1.073529e-03 -1.116841e-03
## ASV2371     -2.245678e-03 -2.343300e-03 -2.444777e-03 -2.550231e-03
## ASV0024     -7.334576e-04 -7.674633e-04 -8.030016e-04 -8.401373e-04
## ASV2452      2.243620e-03  2.337479e-03  2.434667e-03  2.535248e-03
## ASV2332     -6.459376e-03 -6.743185e-03 -7.038483e-03 -7.345655e-03
## ASV2591      1.731602e-03  1.819207e-03  1.911335e-03  2.008218e-03
## ASV0521      1.489838e-03  1.558821e-03  1.630909e-03  1.706233e-03
## ASV5542      1.426417e-03  1.492474e-03  1.561480e-03  1.633557e-03
## ASV0336     -1.867609e-04 -1.974371e-04 -2.087680e-04 -2.207957e-04
## ASV10102     2.634495e-03  2.756293e-03  2.883540e-03  3.016463e-03
## ASV16823    -4.012290e-03 -4.181929e-03 -4.357846e-03 -4.540201e-03
## ASV3104      2.075598e-02  2.163335e-02  2.254317e-02  2.348626e-02
## ASV0781      2.925313e-03  3.056845e-03  3.193947e-03  3.336822e-03
## ASV10899     1.753549e-03  1.842925e-03  1.937030e-03  2.036122e-03
## ASV11222    -7.059869e-03 -7.358268e-03 -7.667703e-03 -7.988454e-03
## ASV11327    -6.337149e-03 -6.604942e-03 -6.882633e-03 -7.170475e-03
## ASV12458    -7.056827e-03 -7.354966e-03 -7.664119e-03 -7.984567e-03
## ASV1636      4.009561e-03  4.185356e-03  4.368181e-03  4.558259e-03
## ASV1890     -3.225310e-03 -3.355656e-03 -3.490293e-03 -3.629285e-03
## ASV2898      5.377061e-03  5.613120e-03  5.858658e-03  6.113981e-03
## ASV8328      6.913996e-04  7.391281e-04  7.903556e-04  8.453405e-04
## ASV0709     -6.008654e-03 -6.276600e-03 -6.555658e-03 -6.846215e-03
## ASV0856      5.031246e-03  5.268328e-03  5.516417e-03  5.776005e-03
## ASV0909      1.484253e-03  1.564384e-03  1.649123e-03  1.738749e-03
## ASV0937     -3.549956e-03 -3.713835e-03 -3.885081e-03 -4.064012e-03
## ASV11390    -1.006988e-02 -1.049526e-02 -1.093634e-02 -1.139353e-02
## ASV11966     2.472721e-03  2.591988e-03  2.717012e-03  2.848064e-03
## ASV12990     1.765313e-03  1.842031e-03  1.921736e-03  2.004514e-03
## ASV14797     2.610606e-03  2.722708e-03  2.839082e-03  2.959844e-03
## ASV14904    -1.444932e-02 -1.505967e-02 -1.569256e-02 -1.634857e-02
## ASV15304     1.558595e-03  1.636800e-03  1.719022e-03  1.805468e-03
## ASV16696    -4.991739e-03 -5.202563e-03 -5.421172e-03 -5.647763e-03
## ASV1690      8.553357e-03  8.957446e-03  9.380298e-03  9.822738e-03
## ASV2029      5.903191e-03  6.165316e-03  6.438253e-03  6.722380e-03
## ASV2834      7.429650e-03  7.770058e-03  8.125444e-03  8.496410e-03
## ASV4003      6.151807e-03  6.449224e-03  6.761152e-03  7.088306e-03
## ASV4064      3.529588e-03  3.692615e-03  3.862920e-03  4.040802e-03
## ASV4294      2.157072e-03  2.265287e-03  2.379095e-03  2.498792e-03
## ASV4609      1.995400e-03  2.083537e-03  2.175252e-03  2.270665e-03
## ASV6283     -4.666781e-03 -4.863922e-03 -5.068348e-03 -5.280244e-03
## ASV6491     -6.687509e-03 -6.969950e-03 -7.262822e-03 -7.566391e-03
## ASV7453      3.282011e-03  3.441267e-03  3.608288e-03  3.783447e-03
## ASV7959      1.196409e-03  1.260503e-03  1.328218e-03  1.399768e-03
## ASV8219      5.778870e-02  6.022919e-02  6.275982e-02  6.538287e-02
## ASV8547     -5.985473e-03 -6.238191e-03 -6.500239e-03 -6.771852e-03
## ASV9319      2.637505e-03  2.761327e-03  2.890861e-03  3.026359e-03
## ASV9382     -1.170997e-02 -1.220434e-02 -1.271695e-02 -1.324827e-02
## ASV11516    -7.819638e-03 -8.149691e-03 -8.491919e-03 -8.846631e-03
## ASV14377    -5.644987e-03 -5.883199e-03 -6.130194e-03 -6.386194e-03
## ASV1867      4.415823e-03  4.619769e-03  4.832836e-03  5.055404e-03
## ASV1895      2.194485e-03  2.286318e-03  2.381385e-03  2.479744e-03
## ASV3168      2.769719e-03  2.888594e-03  3.011963e-03  3.139939e-03
## ASV4449      1.533096e-02  1.601923e-02  1.673669e-02  1.748445e-02
## ASV6596      3.224602e-03  3.382774e-03  3.548849e-03  3.723230e-03
## ASV7492     -5.490825e-04 -5.613877e-04 -5.731411e-04 -5.842326e-04
## ASV9854     -1.204787e-03 -1.254712e-03 -1.306412e-03 -1.359930e-03
## ASV6296      9.470157e-02  9.869690e-02  1.028395e-01  1.071330e-01
## ASV4201      4.939019e-04  5.292585e-04  5.672803e-04  6.081676e-04
## ASV0552      3.053907e-03  3.194282e-03  3.340874e-03  3.493938e-03
## ASV3671     -2.026665e-03 -2.116533e-03 -2.210149e-03 -2.307655e-03
## ASV3529     -5.029181e-04 -5.156164e-04 -5.280226e-04 -5.400605e-04
## ASV1060      8.154739e-04  8.541962e-04  8.947551e-04  9.372378e-04
## ASV0239     -1.086424e-03 -1.131629e-03 -1.178425e-03 -1.226844e-03
## ASV5711     -4.949248e-03 -5.166731e-03 -5.393028e-03 -5.628438e-03
## ASV4152     -7.025125e-03 -7.343720e-03 -7.676086e-03 -8.022763e-03
## ASV1461      3.509268e-03  3.656580e-03  3.809186e-03  3.967200e-03
## ASV2877      1.825240e-03  1.902884e-03  1.983408e-03  2.066880e-03
## ASV0012      3.172702e-04  3.315974e-04  3.465379e-04  3.621151e-04
## ASV9823      4.400094e-04  4.556785e-04  4.716217e-04  4.878123e-04
## ASV0008      3.381513e-04  3.533113e-04  3.691109e-04  3.855739e-04
## ASV7832     -4.138652e-03 -4.327513e-03 -4.524675e-03 -4.730481e-03
## ASV1915     -5.215025e-04 -5.439792e-04 -5.673499e-04 -5.916463e-04
## ASV0055     -3.700602e-04 -3.886290e-04 -4.081602e-04 -4.287052e-04
## ASV0032      1.658607e-04  1.721916e-04  1.786907e-04  1.853556e-04
## ASV2977     -5.825819e-03 -6.088915e-03 -6.363282e-03 -6.649351e-03
## ASV0466      4.643887e-03  4.839091e-03  5.041347e-03  5.250809e-03
## ASV3866      3.212117e-03  3.361521e-03  3.517709e-03  3.680977e-03
## ASV0040      1.157772e-03  1.210644e-03  1.265830e-03  1.323423e-03
## ASV0496     -2.906058e-04 -3.097948e-04 -3.303500e-04 -3.523710e-04
## ASV0052      9.722078e-04  1.016673e-03  1.063090e-03  1.111536e-03
## ASV3828     -3.353041e-03 -3.494009e-03 -3.640127e-03 -3.791521e-03
## ASV1930      1.726167e-03  1.801193e-03  1.879143e-03  1.960102e-03
## ASV2126      2.949882e-03  3.080981e-03  3.217496e-03  3.359615e-03
## ASV0793      3.636667e-03  3.804993e-03  3.980882e-03  4.164653e-03
## ASV0299     -7.201100e-05 -7.558175e-05 -7.935109e-05 -8.333313e-05
## ASV0208      2.621480e-03  2.741139e-03  2.866034e-03  2.996377e-03
## ASV0511     -1.066814e-03 -1.110980e-03 -1.156668e-03 -1.203904e-03
## ASV1123     -3.231878e-03 -3.367243e-03 -3.507469e-03 -3.652661e-03
## ASV0099      9.988330e-05  1.051684e-04  1.107558e-04  1.166647e-04
## ASV0752     -1.875056e-03 -1.964025e-03 -2.057177e-03 -2.154705e-03
## ASV0883      2.570483e-03  2.691867e-03  2.818907e-03  2.951858e-03
## ASV0683      3.355950e-03  3.512722e-03  3.676663e-03  3.848086e-03
## ASV4117     -5.331187e-03 -5.574350e-03 -5.828169e-03 -6.093078e-03
## ASV2172      3.389520e-04  3.516690e-04  3.646894e-04  3.780025e-04
## ASV0330     -9.972884e-04 -1.043232e-03 -1.091224e-03 -1.141350e-03
## ASV0728      4.914460e-03  5.135896e-03  5.366729e-03  5.607306e-03
## ASV0499      1.306629e-03  1.367933e-03  1.432067e-03  1.499159e-03
## ASV0120     -2.180346e-03 -2.278838e-03 -2.381531e-03 -2.488584e-03
## ASV1446      1.646050e-03  1.709629e-03  1.774985e-03  1.842104e-03
## ASV17171    -4.210198e-03 -4.399721e-03 -4.597341e-03 -4.803370e-03
## ASV0533      3.168503e-04  3.324215e-04  3.487721e-04  3.659416e-04
## ASV2495     -1.046889e-03 -1.100272e-03 -1.156519e-03 -1.215795e-03
## ASV5582      1.922967e-03  2.000152e-03  2.079776e-03  2.161858e-03
## ASV1488      7.403293e-04  7.723350e-04  8.055709e-04  8.400700e-04
## ASV0682      9.526885e-04  9.976645e-04  1.044739e-03  1.094007e-03
## ASV0068     -1.652270e-03 -1.727308e-03 -1.805584e-03 -1.887225e-03
## ASV1987     -4.136016e-03 -4.332973e-03 -4.539255e-03 -4.755295e-03
## ASV0035     -3.148088e-04 -3.329568e-04 -3.522511e-04 -3.727701e-04
## ASV7192     -2.550026e-03 -2.662310e-03 -2.779149e-03 -2.900697e-03
## ASV0873     -4.662265e-04 -5.566568e-04 -6.568385e-04 -7.676138e-04
## ASV4749     -1.131071e-04 -1.303030e-04 -1.493293e-04 -1.703529e-04
## ASV2174      1.759040e-03  1.830763e-03  1.904856e-03  1.981348e-03
## ASV1476     -1.831304e-03 -1.917586e-03 -2.007903e-03 -2.102444e-03
## ASV0740     -5.198097e-03 -5.442251e-03 -5.697702e-03 -5.964959e-03
## ASV0170     -1.013682e-03 -1.059796e-03 -1.107914e-03 -1.158112e-03
## ASV2466     -4.621928e-03 -4.832364e-03 -5.051983e-03 -5.281153e-03
## ASV1709      1.686067e-03  1.759286e-03  1.835434e-03  1.914616e-03
## ASV6170     -7.252434e-03 -7.588994e-03 -7.940770e-03 -8.308417e-03
## ASV3673      3.566279e-03  3.733710e-03  3.908880e-03  4.092137e-03
## ASV1745     -9.280483e-04 -9.734517e-04 -1.021114e-03 -1.071150e-03
##                                                                    
## (Intercept)  2.940797e-02  3.073345e-02  3.211512e-02  3.355505e-02
## ASV1236      5.746326e-03  5.993375e-03  6.249925e-03  6.516249e-03
## ASV0421      7.001281e-04  7.386699e-04  7.794626e-04  8.226414e-04
## ASV0691     -4.384980e-03 -4.556897e-03 -4.733950e-03 -4.916158e-03
## ASV0899      4.986616e-03  5.202087e-03  5.425871e-03  5.658202e-03
## ASV1004      1.151615e-02  1.201313e-02  1.252933e-02  1.306528e-02
## ASV1041     -4.728044e-03 -4.930379e-03 -5.140314e-03 -5.358041e-03
## ASV1058      7.184223e-03  7.493651e-03  7.815004e-03  8.148628e-03
## ASV12542     2.768335e-03  2.884289e-03  3.004425e-03  3.128839e-03
## ASV1294      6.688879e-03  6.977515e-03  7.277323e-03  7.588631e-03
## ASV13113     2.292424e-03  2.402207e-03  2.517257e-03  2.637826e-03
## ASV1318      6.668114e-03  6.955475e-03  7.253912e-03  7.563744e-03
## ASV2269     -1.153480e-02 -1.202960e-02 -1.254322e-02 -1.307616e-02
## ASV2542      5.715020e-03  5.977928e-03  6.252530e-03  6.539311e-03
## ASV2660     -4.582990e-03 -4.778265e-03 -4.980859e-03 -5.190960e-03
## ASV2737      1.568601e-03  1.632104e-03  1.697710e-03  1.765450e-03
## ASV2840      6.068969e-03  6.319744e-03  6.579179e-03  6.847427e-03
## ASV3053      3.117708e-02  3.248721e-02  3.384496e-02  3.525146e-02
## ASV3077      1.990887e-03  2.075024e-03  2.162271e-03  2.252707e-03
## ASV3134      3.643246e-03  3.814684e-03  3.994092e-03  4.181830e-03
## ASV3140      4.885065e-03  5.104843e-03  5.333931e-03  5.572674e-03
## ASV3579      1.773440e-03  1.861061e-03  1.953103e-03  2.049793e-03
## ASV6119     -3.156206e-03 -3.291562e-03 -3.432062e-03 -3.577846e-03
## ASV7557     -6.412458e-03 -6.687384e-03 -6.972752e-03 -7.268843e-03
## ASV8422      1.591956e-03  1.659044e-03  1.728594e-03  1.800669e-03
## ASV1086     -2.422864e-04 -2.513813e-04 -2.607173e-04 -2.702933e-04
## ASV1310      3.074912e-03  3.207139e-03  3.344431e-03  3.486929e-03
## ASV15750    -4.111518e-04 -4.274683e-04 -4.442799e-04 -4.615875e-04
## ASV16905    -1.318613e-03 -1.375147e-03 -1.433828e-03 -1.494714e-03
## ASV2033      5.755198e-03  6.022928e-03  6.302783e-03  6.595278e-03
## ASV2089      2.781386e-03  2.900786e-03  3.024735e-03  3.153355e-03
## ASV2127      9.038046e-03  9.426879e-03  9.830645e-03  1.024977e-02
## ASV2725      7.198371e-03  7.502304e-03  7.817393e-03  8.143907e-03
## ASV2804     -2.729377e-03 -2.846383e-03 -2.967833e-03 -3.093846e-03
## ASV3075      6.043513e-03  6.313034e-03  6.593858e-03  6.886405e-03
## ASV3327      8.420752e-03  8.806530e-03  9.209284e-03  9.629697e-03
## ASV3342      7.222416e-03  7.550847e-03  7.893535e-03  8.251040e-03
## ASV3532     -7.940708e-03 -8.297090e-03 -8.668549e-03 -9.055648e-03
## ASV3600      3.696331e-03  3.863120e-03  4.037041e-03  4.218368e-03
## ASV4013      6.847096e-03  7.147962e-03  7.460949e-03  7.786453e-03
## ASV4136      7.233717e-03  7.540407e-03  7.858515e-03  8.188338e-03
## ASV4195      2.785438e-02  2.904813e-02  3.028719e-02  3.157277e-02
## ASV4407     -1.075964e-02 -1.122063e-02 -1.169911e-02 -1.219555e-02
## ASV4717      1.839329e-03  1.912652e-03  1.988292e-03  2.066271e-03
## ASV6794      4.424049e-03  4.607991e-03  4.798473e-03  4.995641e-03
## ASV8324     -5.521052e-03 -5.757600e-03 -6.003120e-03 -6.257853e-03
## ASV8981     -1.137583e-04 -1.147981e-04 -1.155143e-04 -1.158624e-04
## ASV9859      2.005743e-03  2.106796e-03  2.213135e-03  2.325051e-03
## ASV0936      5.447085e-03  5.694948e-03  5.953546e-03  6.223295e-03
## ASV12683    -1.353527e-05 -1.530764e-05 -1.724477e-05 -1.935847e-05
## ASV1293      3.579408e-03  3.732462e-03  3.891307e-03  4.056097e-03
## ASV13055    -6.762199e-05 -6.771280e-05 -6.754169e-05 -6.707551e-05
## ASV17063    -2.862400e-03 -2.984922e-03 -3.112082e-03 -3.244003e-03
## ASV2228      2.333819e-03  2.433688e-03  2.537335e-03  2.644861e-03
## ASV2769      3.932976e-04  4.143283e-04  4.365360e-04  4.599875e-04
## ASV2803      2.498741e-03  2.601366e-03  2.707502e-03  2.817212e-03
## ASV2896      2.061213e-03  2.156184e-03  2.255414e-03  2.359086e-03
## ASV3062      2.526531e-03  2.648913e-03  2.777265e-03  2.911874e-03
## ASV3107      3.829812e-03  4.004290e-03  4.186385e-03  4.376403e-03
## ASV3265      5.116827e-03  5.334889e-03  5.561126e-03  5.795750e-03
## ASV3666      4.672705e-05  4.823079e-05  4.973845e-05  5.124418e-05
## ASV4497      1.765596e-03  1.842084e-03  1.921558e-03  2.004107e-03
## ASV6914     -2.799506e-04 -2.946152e-04 -3.100843e-04 -3.264035e-04
## ASV0576     -6.030953e-03 -6.275970e-03 -6.529128e-03 -6.790547e-03
## ASV0673      6.818014e-03  7.116168e-03  7.426199e-03  7.748481e-03
## ASV0772      3.173609e-03  3.313863e-03  3.459855e-03  3.611782e-03
## ASV0862      3.724889e-04  3.993946e-04  4.283206e-04  4.594144e-04
## ASV0898      2.508745e-03  2.626366e-03  2.749380e-03  2.878021e-03
## ASV0910      2.876162e-03  3.008030e-03  3.145721e-03  3.289474e-03
## ASV0964     -2.290077e-03 -2.384635e-03 -2.482462e-03 -2.583618e-03
## ASV10059     2.069924e-03  2.168464e-03  2.271673e-03  2.379766e-03
## ASV10263    -4.363038e-03 -4.550107e-03 -4.744286e-03 -4.945769e-03
## ASV1088      5.112308e-03  5.344344e-03  5.586464e-03  5.839074e-03
## ASV1101      6.230955e-03  6.497088e-03  6.773244e-03  7.059689e-03
## ASV1183      1.670109e-03  1.744998e-03  1.823047e-03  1.904370e-03
## ASV11956     1.571666e-03  1.635191e-03  1.700801e-03  1.768526e-03
## ASV12774     7.175092e-05  7.157751e-05  7.109653e-05  7.027113e-05
## ASV1321      7.446288e-03  7.790858e-03  8.150913e-03  8.527108e-03
## ASV13793    -3.008025e-03 -3.136975e-03 -3.270824e-03 -3.409705e-03
## ASV14482     1.845191e-04  1.913753e-04  1.984153e-04  2.056397e-04
## ASV15483     1.259968e-03  1.317514e-03  1.377575e-03  1.440250e-03
## ASV2062      5.802619e-03  6.057007e-03  6.321616e-03  6.596781e-03
## ASV2132      4.789381e-03  5.007367e-03  5.234819e-03  5.472110e-03
## ASV2413      4.465356e-03  4.657834e-03  4.857757e-03  5.065344e-03
## ASV2490      1.363807e-02  1.420891e-02  1.480029e-02  1.541266e-02
## ASV2594      1.739587e-03  1.817971e-03  1.899723e-03  1.984978e-03
## ASV2822     -7.940651e-03 -8.281295e-03 -8.634905e-03 -9.001835e-03
## ASV2863      8.420928e-03  8.778091e-03  9.148557e-03  9.532674e-03
## ASV2910      3.089364e-03  3.221581e-03  3.358816e-03  3.501205e-03
## ASV2980      3.473474e-03  3.626236e-03  3.785167e-03  3.950470e-03
## ASV3307      6.316038e-03  6.586835e-03  6.867925e-03  7.159589e-03
## ASV3474      4.278483e-03  4.478724e-03  4.688152e-03  4.907170e-03
## ASV3502      4.432383e-03  4.630291e-03  4.836470e-03  5.051219e-03
## ASV4236      6.398219e-03  6.663699e-03  6.938477e-03  7.222732e-03
## ASV4842     -7.100442e-04 -7.429085e-04 -7.771960e-04 -8.129550e-04
## ASV4894     -3.009365e-03 -3.138451e-03 -3.272450e-03 -3.411495e-03
## ASV5290      2.427316e-03  2.537290e-03  2.651991e-03  2.771598e-03
## ASV5501      1.478135e-03  1.544295e-03  1.613265e-03  1.685153e-03
## ASV5795      1.632877e-03  1.707152e-03  1.784649e-03  1.865493e-03
## ASV5987     -8.406854e-03 -8.767575e-03 -9.142037e-03 -9.530617e-03
## ASV6267     -9.470912e-03 -9.877177e-03 -1.029891e-02 -1.073653e-02
## ASV6862      3.778563e-03  3.937018e-03  4.101213e-03  4.271283e-03
## ASV7145      1.659266e-03  1.727518e-03  1.798158e-03  1.871240e-03
## ASV7673     -3.009122e-03 -3.138193e-03 -3.272175e-03 -3.411205e-03
## ASV7789      1.557692e-03  1.635308e-03  1.716900e-03  1.802678e-03
## ASV7809      1.264538e-04  1.359198e-04  1.461160e-04  1.570968e-04
## ASV8002     -3.800345e-03 -3.963360e-03 -4.132582e-03 -4.308180e-03
## ASV8205      1.613569e-03  1.686395e-03  1.762338e-03  1.841519e-03
## ASV9155     -9.592601e-04 -9.992632e-04 -1.040682e-03 -1.083546e-03
## ASV9221      4.343738e-04  4.602498e-04  4.877912e-04  5.171098e-04
## ASV9311     -6.095906e-03 -6.357368e-03 -6.628785e-03 -6.910429e-03
## ASV9557     -4.165247e-03 -4.343851e-03 -4.529250e-03 -4.721631e-03
## ASV9936     -8.398081e-03 -8.758086e-03 -9.131779e-03 -9.519536e-03
## ASV1445      5.174616e-03  5.408278e-03  5.651929e-03  5.905948e-03
## ASV4232      1.987970e-03  2.082806e-03  2.182181e-03  2.286314e-03
## ASV6479      7.495585e-04  7.919481e-04  8.369082e-04  8.846023e-04
## ASV0142     -3.612680e-03 -3.766278e-03 -3.925617e-03 -4.090846e-03
## ASV0378      1.693161e-03  1.773795e-03  1.858245e-03  1.946689e-03
## ASV1122      5.019719e-03  5.248268e-03  5.486757e-03  5.735577e-03
## ASV0123     -3.188270e-03 -3.323487e-03 -3.463726e-03 -3.609115e-03
## ASV2064      1.608549e-03  1.672863e-03  1.739189e-03  1.807538e-03
## ASV4459     -2.187435e-04 -2.264410e-04 -2.342916e-04 -2.422886e-04
## ASV0448      1.354510e-03  1.419106e-03  1.486764e-03  1.557628e-03
## ASV0397      2.930081e-03  3.059963e-03  3.195182e-03  3.335923e-03
## ASV0485      3.391083e-03  3.539038e-03  3.692875e-03  3.852779e-03
## ASV1566      5.012037e-03  5.233430e-03  5.463848e-03  5.703594e-03
## ASV1365      4.296483e-03  4.488961e-03  4.689509e-03  4.898416e-03
## ASV1065      6.101817e-03  6.374563e-03  6.658722e-03  6.954707e-03
## ASV0722     -3.226854e-04 -3.378498e-04 -3.537253e-04 -3.703458e-04
## ASV12660    -3.450950e-03 -3.596630e-03 -3.747679e-03 -3.904234e-03
## ASV0223      9.381404e-04  9.793204e-04  1.022165e-03  1.066730e-03
## ASV0229      1.446784e-03  1.512877e-03  1.581870e-03  1.653881e-03
## ASV0877      5.847553e-04  6.075598e-04  6.309872e-04  6.550260e-04
## ASV0983      3.359686e-03  3.505145e-03  3.656270e-03  3.813229e-03
## ASV0626      4.045507e-04  4.292434e-04  4.555381e-04  4.835390e-04
## ASV4146      1.640773e-04  1.708560e-04  1.778326e-04  1.850012e-04
## ASV4175     -4.191527e-03 -4.381704e-03 -4.580088e-03 -4.786996e-03
## ASV2082     -1.964734e-03 -2.067404e-03 -2.175740e-03 -2.290071e-03
## ASV2272      1.992813e-03  2.082767e-03  2.176581e-03  2.274406e-03
## ASV2245     -2.998835e-03 -3.135793e-03 -3.278735e-03 -3.427898e-03
## ASV0590     -1.874710e-03 -1.976204e-03 -2.083541e-03 -2.197075e-03
## ASV0217      2.115432e-04  2.306212e-04  2.513407e-04  2.738322e-04
## ASV0416      2.196656e-03  2.283187e-03  2.372312e-03  2.464035e-03
## ASV1056      2.913766e-03  3.049203e-03  3.190762e-03  3.338700e-03
## ASV7777     -4.072350e-03 -4.255965e-03 -4.447427e-03 -4.647037e-03
## ASV0455      7.288342e-04  7.613245e-04  7.951633e-04  8.303976e-04
## ASV0604      1.926027e-03  2.016877e-03  2.111945e-03  2.211418e-03
## ASV6100     -2.817834e-03 -2.946918e-03 -3.081703e-03 -3.222422e-03
## ASV11359    -6.032034e-03 -6.303838e-03 -6.587198e-03 -6.882544e-03
## ASV6604      8.456559e-04  8.853236e-04  9.268160e-04  9.702130e-04
## ASV5004     -2.140335e-03 -2.235935e-03 -2.335539e-03 -2.439294e-03
## ASV1483     -9.197810e-04 -9.604752e-04 -1.002834e-03 -1.046915e-03
## ASV9773     -2.722353e-03 -2.845960e-03 -2.974922e-03 -3.109450e-03
## ASV4059      4.881548e-05  5.832521e-05  6.888372e-05  8.058513e-05
## ASV1193      3.270311e-03  3.415531e-03  3.566741e-03  3.724153e-03
## ASV4610     -4.566103e-04 -4.671292e-04 -4.772655e-04 -4.869413e-04
## ASV0742     -2.611569e-04 -2.644736e-04 -2.672066e-04 -2.692752e-04
## ASV1502     -1.789165e-04 -1.921836e-04 -2.064695e-04 -2.218501e-04
## ASV0195      6.014039e-05  5.964522e-05  5.885784e-05  5.774559e-05
## ASV1213      2.256281e-03  2.348400e-03  2.443615e-03  2.541973e-03
## ASV1648     -2.529257e-03 -2.644885e-03 -2.765606e-03 -2.891629e-03
## ASV6984     -2.367356e-03 -2.475754e-03 -2.588946e-03 -2.707130e-03
## ASV0396     -1.119402e-04 -1.134374e-04 -1.147070e-04 -1.157187e-04
## ASV4297      3.292557e-03  3.430344e-03  3.573069e-03  3.720841e-03
## ASV2622      5.143123e-03  5.364502e-03  5.594403e-03  5.833072e-03
## ASV3512      2.086861e-03  2.191025e-03  2.300551e-03  2.415727e-03
## ASV2411      3.581871e-03  3.749111e-03  3.923993e-03  4.106850e-03
## ASV2291     -1.630329e-03 -1.720123e-03 -1.815183e-03 -1.915828e-03
## ASV0807      4.817456e-03  5.031474e-03  5.254316e-03  5.486288e-03
## ASV1292      1.129348e-03  1.173907e-03  1.219819e-03  1.267090e-03
## ASV1035      4.367717e-03  4.553615e-03  4.746516e-03  4.946613e-03
## ASV0070      5.952596e-05  6.572953e-05  7.251387e-05  7.992857e-05
## ASV0255      4.067842e-04  4.228559e-04  4.394009e-04  4.564172e-04
## ASV0057     -1.190019e-03 -1.238651e-03 -1.288915e-03 -1.340832e-03
## ASV0077     -2.443665e-04 -2.529975e-04 -2.617872e-04 -2.707239e-04
## ASV0625      2.507443e-03  2.612823e-03  2.722026e-03  2.835140e-03
## ASV2464      1.703759e-02  1.775041e-02  1.848899e-02  1.925396e-02
## ASV1315      4.675082e-03  4.894702e-03  5.124470e-03  5.364836e-03
## ASV2673      4.012381e-03  4.201233e-03  4.398845e-03  4.605607e-03
## ASV2161      1.694935e-03  1.774442e-03  1.857623e-03  1.944643e-03
## ASV0337     -9.622744e-04 -1.006084e-03 -1.051796e-03 -1.099487e-03
## ASV7680     -6.287653e-03 -6.575171e-03 -6.875307e-03 -7.188571e-03
## ASV0611      3.513938e-03  3.675012e-03  3.843200e-03  4.018793e-03
## ASV3118     -3.684223e-03 -3.858686e-03 -4.041322e-03 -4.232503e-03
## ASV1284      1.147498e-03  1.175449e-03  1.202478e-03  1.228368e-03
## ASV0889      2.617930e-03  2.731690e-03  2.849942e-03  2.972828e-03
## ASV4649     -1.323850e-03 -1.383288e-03 -1.445241e-03 -1.509803e-03
## ASV1108     -2.770910e-03 -2.904442e-03 -3.044445e-03 -3.191230e-03
## ASV0738      1.564093e-03  1.644602e-03  1.729442e-03  1.818855e-03
## ASV0473     -3.304721e-04 -3.493177e-04 -3.692900e-04 -3.904556e-04
## ASV0598     -8.113993e-04 -8.550571e-04 -9.012216e-04 -9.500457e-04
## ASV0429      1.930904e-03  2.012814e-03  2.097747e-03  2.185776e-03
## ASV1549      3.704312e-03  3.879001e-03  4.061823e-03  4.253143e-03
## ASV1203      2.851040e-03  2.975464e-03  3.104825e-03  3.239276e-03
## ASV4532      1.127329e-04  1.161725e-04  1.196310e-04  1.231004e-04
## ASV0274      5.164874e-04  5.420330e-04  5.688540e-04  5.970123e-04
## ASV0163     -2.175581e-03 -2.266598e-03 -2.360893e-03 -2.458542e-03
## ASV1298      2.286589e-04  2.368679e-04  2.452720e-04  2.538701e-04
## ASV9424     -4.884164e-03 -5.109083e-03 -5.344036e-03 -5.589444e-03
## ASV0412      4.934428e-03  5.148057e-03  5.370029e-03  5.600594e-03
## ASV0284      9.961959e-04  1.033929e-03  1.072640e-03  1.112314e-03
## ASV0620     -1.070060e-03 -1.125128e-03 -1.183146e-03 -1.244277e-03
## ASV0153     -4.951662e-03 -5.184997e-03 -5.429166e-03 -5.684653e-03
## ASV0498      1.731083e-03  1.810225e-03  1.892814e-03  1.978985e-03
## ASV0097      9.726672e-04  1.018508e-03  1.066482e-03  1.116685e-03
## ASV0104     -6.738750e-03 -7.036196e-03 -7.345732e-03 -7.667763e-03
## ASV1282      2.293394e-03  2.390013e-03  2.490124e-03  2.593804e-03
## ASV3883     -1.914223e-03 -2.008398e-03 -2.107268e-03 -2.211067e-03
## ASV0801      9.228608e-04  9.650210e-04  1.009024e-03  1.054945e-03
## ASV1611     -4.394863e-03 -4.599580e-03 -4.813616e-03 -5.037376e-03
## ASV0227     -8.333254e-04 -8.778949e-04 -9.249740e-04 -9.747086e-04
## ASV0833      1.482910e-03  1.550264e-03  1.620523e-03  1.693800e-03
## ASV0718      6.623394e-03  6.922859e-03  7.235178e-03  7.560846e-03
## ASV1139      7.903652e-04  8.167179e-04  8.433645e-04  8.702437e-04
## ASV0766     -9.530410e-04 -1.000074e-03 -1.049457e-03 -1.101309e-03
## ASV2091      5.267860e-03  5.489518e-03  5.719226e-03  5.957171e-03
## ASV1238     -4.957766e-03 -5.186837e-03 -5.426224e-03 -5.676376e-03
## ASV9193     -5.270721e-04 -5.589344e-04 -5.928946e-04 -6.290986e-04
## ASV0290      6.634620e-04  6.879127e-04  7.129481e-04  7.385549e-04
## ASV0231      1.942040e-03  2.026030e-03  2.113284e-03  2.203896e-03
## ASV0185      1.198005e-03  1.259379e-03  1.324034e-03  1.392150e-03
## ASV2330      2.194545e-03  2.284904e-03  2.378365e-03  2.474984e-03
## ASV3119     -1.081708e-03 -1.136670e-03 -1.194529e-03 -1.255440e-03
## ASV2368     -2.565385e-03 -2.686912e-03 -2.814175e-03 -2.947443e-03
## ASV0122     -1.211761e-03 -1.264871e-03 -1.320112e-03 -1.377555e-03
## ASV1044      3.167066e-03  3.314682e-03  3.469028e-03  3.630397e-03
## ASV0160     -1.278751e-03 -1.331600e-03 -1.386286e-03 -1.442845e-03
## ASV0326      3.479793e-04  3.638048e-04  3.803099e-04  3.975198e-04
## ASV1388      6.295350e-03  6.572497e-03  6.860849e-03  7.160772e-03
## ASV0792      4.629708e-03  4.827527e-03  5.032813e-03  5.245767e-03
## ASV0036     -1.485766e-03 -1.555812e-03 -1.629107e-03 -1.705795e-03
## ASV2125      4.511586e-03  4.711858e-03  4.920376e-03  5.137426e-03
## ASV1075     -6.809499e-05 -7.117903e-05 -7.440455e-05 -7.777901e-05
## ASV0390      2.453703e-03  2.569518e-03  2.690753e-03  2.817654e-03
## ASV3790     -3.448159e-03 -3.605630e-03 -3.769998e-03 -3.941541e-03
## ASV1535     -1.027551e-03 -1.079289e-03 -1.133714e-03 -1.190970e-03
## ASV0263      4.201120e-03  4.389760e-03  4.586375e-03  4.791259e-03
## ASV0675      6.368218e-03  6.662277e-03  6.969495e-03  7.290426e-03
## ASV3348      5.264631e-04  5.522547e-04  5.793250e-04  6.077371e-04
## ASV0058     -1.859722e-03 -1.941269e-03 -2.026082e-03 -2.114268e-03
## ASV4142      2.585705e-03  2.695628e-03  2.809631e-03  2.927814e-03
## ASV0059     -1.494100e-03 -1.559023e-03 -1.626494e-03 -1.696589e-03
## ASV0013     -2.679975e-03 -2.799992e-03 -2.925050e-03 -3.055333e-03
## ASV0033     -1.289780e-03 -1.350342e-03 -1.413694e-03 -1.479959e-03
## ASV4354     -1.580257e-03 -1.651356e-03 -1.725498e-03 -1.802801e-03
## ASV0022     -1.088767e-03 -1.139838e-03 -1.193261e-03 -1.249137e-03
## ASV0134     -1.048971e-03 -1.100142e-03 -1.153840e-03 -1.210192e-03
## ASV0415      1.769381e-04  1.867157e-04  1.970535e-04  2.079827e-04
## ASV10103    -6.018278e-03 -6.296337e-03 -6.586853e-03 -6.890349e-03
## ASV1613      4.390647e-03  4.578402e-03  4.773239e-03  4.975344e-03
## ASV0135     -5.569558e-04 -5.796505e-04 -6.030980e-04 -6.273083e-04
## ASV0469     -5.697114e-03 -5.945470e-03 -6.203693e-03 -6.472096e-03
## ASV0471      3.491537e-03  3.647352e-03  3.809665e-03  3.978710e-03
## ASV0451     -6.139383e-04 -6.478194e-04 -6.836902e-04 -7.216723e-04
## ASV0747      1.996544e-03  2.087082e-03  2.181518e-03  2.280000e-03
## ASV1314     -2.032799e-03 -2.129272e-03 -2.230304e-03 -2.336108e-03
## ASV0425     -6.999721e-03 -7.296615e-03 -7.604526e-03 -7.923731e-03
## ASV0559     -1.753869e-03 -1.831858e-03 -1.913112e-03 -1.997757e-03
## ASV0148     -3.694833e-04 -3.815947e-04 -3.938120e-04 -4.061029e-04
## ASV0129      4.651406e-04  4.943744e-04  5.256027e-04  5.589674e-04
## ASV1072      4.528664e-04  4.702210e-04  4.880352e-04  5.063009e-04
## ASV2390      3.560879e-03  3.707803e-03  3.859762e-03  4.016837e-03
## ASV0548      2.399807e-03  2.506467e-03  2.617533e-03  2.733156e-03
## ASV0168     -1.224035e-03 -1.277224e-03 -1.332505e-03 -1.389944e-03
## ASV0066     -1.382901e-03 -1.443566e-03 -1.506660e-03 -1.572259e-03
## ASV0468     -7.381730e-04 -7.714708e-04 -8.061936e-04 -8.423963e-04
## ASV0172     -3.993387e-04 -4.145066e-04 -4.300662e-04 -4.460101e-04
## ASV0236     -9.023003e-06  1.242705e-06  1.289326e-05  2.606228e-05
## ASV0250      2.023376e-03  2.123588e-03  2.228889e-03  2.339545e-03
## ASV0338      9.447460e-04  9.891437e-04  1.035568e-03  1.084103e-03
## ASV0450     -1.894922e-04 -2.003523e-04 -2.118811e-04 -2.241218e-04
## ASV0377      1.725844e-03  1.801301e-03  1.879764e-03  1.961325e-03
## ASV1022     -7.077945e-05 -7.342652e-05 -7.612613e-05 -7.887333e-05
## ASV6174     -4.563455e-05 -4.889598e-05 -5.241559e-05 -5.621485e-05
## ASV0786     -2.708082e-04 -2.872961e-04 -3.048479e-04 -3.235324e-04
## ASV0053     -1.883238e-03 -1.968081e-03 -2.056530e-03 -2.148720e-03
## ASV0697     -1.128647e-03 -1.176957e-03 -1.227108e-03 -1.279152e-03
## ASV0785      2.391345e-03  2.496009e-03  2.604851e-03  2.718006e-03
## ASV1967     -2.369416e-03 -2.472196e-03 -2.579027e-03 -2.690036e-03
## ASV0385      8.207040e-04  8.598319e-04  9.008025e-04  9.436983e-04
## ASV0295      1.640376e-04  1.747187e-04  1.861515e-04  1.983909e-04
## ASV0072     -1.848655e-03 -1.928060e-03 -2.010490e-03 -2.096026e-03
## ASV0157     -2.062241e-04 -2.104405e-04 -2.143738e-04 -2.179718e-04
## ASV0501      4.071492e-03  4.255707e-03  4.447820e-03  4.648131e-03
## ASV10729    -5.130422e-03 -5.364646e-03 -5.609116e-03 -5.864240e-03
## ASV1470      2.537249e-03  2.641123e-03  2.748495e-03  2.859418e-03
## ASV0050     -4.378566e-03 -4.570871e-03 -4.770906e-03 -4.978924e-03
## ASV0411     -1.006587e-03 -1.053648e-03 -1.102864e-03 -1.154332e-03
## ASV0549      1.611220e-03  1.685505e-03  1.763099e-03  1.844141e-03
## ASV0184      5.314766e-04  5.549284e-04  5.793448e-04  6.047608e-04
## ASV0705      1.043680e-03  1.088486e-03  1.134994e-03  1.183249e-03
## ASV1715      2.236775e-03  2.337347e-03  2.442178e-03  2.551426e-03
## ASV0603      3.528842e-04  3.694608e-04  3.868175e-04  4.049922e-04
## ASV0826      3.759192e-03  3.925587e-03  4.098804e-03  4.279077e-03
## ASV0034     -1.195450e-03 -1.247015e-03 -1.300567e-03 -1.356163e-03
## ASV0838      7.576888e-04  7.798126e-04  8.017662e-04  8.234408e-04
## ASV0614     -1.028617e-03 -1.074058e-03 -1.121357e-03 -1.170577e-03
## ASV0014     -2.731187e-03 -2.852603e-03 -2.979036e-03 -3.110662e-03
## ASV0585      2.463717e-04  2.485811e-04  2.500996e-04  2.508342e-04
## ASV0016     -2.853074e-03 -2.979903e-03 -3.111973e-03 -3.249467e-03
## ASV5394     -2.150313e-03 -2.247661e-03 -2.349190e-03 -2.455059e-03
## ASV0666      4.612679e-03  4.809401e-03  5.013523e-03  5.225240e-03
## ASV2085      9.819321e-04  1.011126e-03  1.040246e-03  1.069179e-03
## ASV0003     -1.944784e-03 -2.031128e-03 -2.121031e-03 -2.214617e-03
## ASV0346      9.966086e-04  1.043788e-03  1.093165e-03  1.144835e-03
## ASV0267      1.048376e-05  1.388280e-05  1.768652e-05  2.193209e-05
## ASV0353      1.575528e-03  1.648821e-03  1.725439e-03  1.805526e-03
## ASV2419      4.173483e-03  4.356754e-03  4.547407e-03  4.745683e-03
## ASV0447      2.312679e-03  2.420657e-03  2.533557e-03  2.651591e-03
## ASV0654      3.380560e-03  3.531191e-03  3.688073e-03  3.851426e-03
## ASV0151      4.733731e-04  4.980283e-04  5.240357e-04  5.514732e-04
## ASV0065     -1.303243e-03 -1.360525e-03 -1.420116e-03 -1.482092e-03
## ASV0527      3.211267e-03  3.353502e-03  3.501573e-03  3.655683e-03
## ASV4055     -5.249019e-04 -5.509389e-04 -5.783173e-04 -6.071107e-04
## ASV0166     -1.596619e-03 -1.664687e-03 -1.735311e-03 -1.808558e-03
## ASV0417     -6.424599e-04 -6.681110e-04 -6.945632e-04 -7.218219e-04
## ASV0078     -9.486711e-04 -9.895074e-04 -1.031906e-03 -1.075908e-03
## ASV0322     -1.570563e-04 -1.610445e-04 -1.648922e-04 -1.685620e-04
## ASV0156     -2.293983e-03 -2.398778e-03 -2.508173e-03 -2.622354e-03
## ASV0648     -4.990562e-03 -5.219953e-03 -5.459516e-03 -5.709668e-03
## ASV0407     -3.781273e-04 -3.961470e-04 -4.150256e-04 -4.348039e-04
## ASV2030     -8.191850e-04 -8.550762e-04 -8.924612e-04 -9.314006e-04
## ASV0300      6.011934e-04  6.296914e-04  6.595253e-04  6.907555e-04
## ASV1150      1.401111e-04  1.475288e-04  1.553565e-04  1.636174e-04
## ASV0958      1.859824e-03  1.948402e-03  2.041190e-03  2.138385e-03
## ASV0216     -2.007578e-03 -2.095268e-03 -2.186479e-03 -2.281327e-03
## ASV0446      3.075499e-03  3.216826e-03  3.364403e-03  3.518482e-03
## ASV0367     -2.006074e-03 -2.096861e-03 -2.191550e-03 -2.290291e-03
## ASV0200     -1.192532e-03 -1.246365e-03 -1.302496e-03 -1.361012e-03
## ASV0334     -6.134293e-04 -6.358662e-04 -6.588198e-04 -6.822750e-04
## ASV1311      7.545691e-04  7.840648e-04  8.144142e-04  8.456143e-04
## ASV0458      1.109917e-03  1.152509e-03  1.196279e-03  1.241218e-03
## ASV1371      1.939600e-04  2.036465e-04  2.138210e-04  2.245071e-04
## ASV0418      2.610501e-03  2.721019e-03  2.835627e-03  2.954430e-03
## ASV0004      3.775639e-04  3.934040e-04  4.098163e-04  4.268139e-04
## ASV1943      7.040375e-03  7.305878e-03  7.578494e-03  7.858181e-03
## ASV1495     -5.834900e-04 -6.179349e-04 -6.545803e-04 -6.935737e-04
## ASV0901     -2.269904e-03 -2.375298e-03 -2.485473e-03 -2.600635e-03
## ASV0628      1.163651e-03  1.210932e-03  1.259764e-03  1.310165e-03
## ASV0400      7.173108e-04  7.479743e-04  7.797874e-04  8.127787e-04
## ASV0116     -6.668512e-04 -6.977053e-04 -7.299478e-04 -7.636378e-04
## ASV0788      5.900624e-03  6.174603e-03  6.460997e-03  6.760340e-03
## ASV0117      4.399817e-04  4.612128e-04  4.834724e-04  5.068099e-04
## ASV3137     -1.350817e-04 -1.408784e-04 -1.468957e-04 -1.531398e-04
## ASV0001      4.044679e-04  4.212845e-04  4.386932e-04  4.567060e-04
## ASV1651      1.156996e-03  1.205836e-03  1.256468e-03  1.308936e-03
## ASV1692      4.910205e-03  5.137536e-03  5.375097e-03  5.623323e-03
## ASV0660      1.683382e-03  1.750506e-03  1.819696e-03  1.890960e-03
## ASV0508      8.357796e-05  8.678157e-05  9.007428e-05  9.345567e-05
## ASV1660     -1.012180e-03 -1.062505e-03 -1.115374e-03 -1.170916e-03
## ASV0233      1.504906e-03  1.572769e-03  1.643528e-03  1.717292e-03
## ASV1343     -2.792935e-03 -2.921718e-03 -3.056255e-03 -3.196788e-03
## ASV0209      1.353867e-03  1.410340e-03  1.468819e-03  1.529345e-03
## ASV0193     -1.585153e-03 -1.651976e-03 -1.721233e-03 -1.792978e-03
## ASV0357      6.481867e-04  6.819244e-04  7.175203e-04  7.550835e-04
## ASV0198      1.215234e-03  1.268323e-03  1.323529e-03  1.380921e-03
## ASV0007      3.549052e-04  3.693145e-04  3.841985e-04  3.995635e-04
## ASV1772     -5.220782e-04 -5.422085e-04 -5.628599e-04 -5.840178e-04
## ASV0009      2.912838e-04  3.027979e-04  3.146612e-04  3.268752e-04
## ASV0006     -3.361629e-04 -3.522761e-04 -3.691616e-04 -3.868558e-04
## ASV0011     -1.149680e-03 -1.202342e-03 -1.257322e-03 -1.314716e-03
## ASV0015      2.200595e-04  2.287398e-04  2.376805e-04  2.468823e-04
## ASV0017      2.480874e-04  2.579058e-04  2.680237e-04  2.784423e-04
## ASV0235     -1.064790e-03 -1.113938e-03 -1.165279e-03 -1.218904e-03
## ASV0382      8.330195e-04  8.713282e-04  9.113131e-04  9.530375e-04
## ASV2357      3.461703e-03  3.620031e-03  3.785320e-03  3.957852e-03
## ASV0567     -6.732562e-04 -7.045101e-04 -7.371918e-04 -7.713658e-04
## ASV0165      5.774238e-04  6.037970e-04  6.313216e-04  6.600433e-04
## ASV0005      8.307962e-04  8.676696e-04  9.060590e-04  9.460165e-04
## ASV0384     -7.416790e-05 -7.491814e-05 -7.546414e-05 -7.577698e-05
## ASV0002      1.536136e-04  1.601560e-04  1.669460e-04  1.739905e-04
## ASV3017      4.341165e-03  4.524703e-03  4.714983e-03  4.912167e-03
## ASV0091     -1.108772e-04 -1.157165e-04 -1.207535e-04 -1.259960e-04
## ASV0186     -1.678332e-03 -1.753397e-03 -1.831599e-03 -1.913048e-03
## ASV0370      8.836867e-04  9.222074e-04  9.622486e-04  1.003857e-03
## ASV0018      1.065647e-03  1.113154e-03  1.162634e-03  1.214156e-03
## ASV1377      1.056343e-02  1.101570e-02  1.148512e-02  1.197217e-02
## ASV0019      1.118383e-03  1.168308e-03  1.220313e-03  1.274472e-03
## ASV0023     -7.067232e-04 -7.394485e-04 -7.736436e-04 -8.093700e-04
## ASV2194      1.141435e-03  1.195171e-03  1.251412e-03  1.310272e-03
## ASV1155      4.416331e-03  4.605281e-03  4.801489e-03  5.005172e-03
## ASV0510     -1.161543e-03 -1.207646e-03 -1.255162e-03 -1.304098e-03
## ASV2371     -2.659785e-03 -2.773562e-03 -2.891687e-03 -3.014286e-03
## ASV0024     -8.789378e-04 -9.194726e-04 -9.618141e-04 -1.006037e-03
## ASV2452      2.639284e-03  2.746830e-03  2.857938e-03  2.972653e-03
## ASV2332     -7.665097e-03 -7.997209e-03 -8.342402e-03 -8.701090e-03
## ASV2591      2.110095e-03  2.217219e-03  2.329854e-03  2.448272e-03
## ASV0521      1.784930e-03  1.867142e-03  1.953016e-03  2.042703e-03
## ASV5542      1.708829e-03  1.787423e-03  1.869471e-03  1.955110e-03
## ASV0336     -2.335645e-04 -2.471215e-04 -2.615167e-04 -2.768030e-04
## ASV10102     3.155296e-03  3.300281e-03  3.451668e-03  3.609714e-03
## ASV16823    -4.729152e-03 -4.924857e-03 -5.127470e-03 -5.337144e-03
## ASV3104      2.446346e-02  2.547556e-02  2.652337e-02  2.760767e-02
## ASV0781      3.485684e-03  3.640748e-03  3.802236e-03  3.970375e-03
## ASV10899     2.140473e-03  2.250371e-03  2.366117e-03  2.488030e-03
## ASV11222    -8.320801e-03 -8.665019e-03 -9.021380e-03 -9.390151e-03
## ASV11327    -7.468717e-03 -7.777606e-03 -8.097385e-03 -8.428294e-03
## ASV12458    -8.316587e-03 -8.660453e-03 -9.016436e-03 -9.384799e-03
## ASV1636      4.755817e-03  4.961081e-03  5.174281e-03  5.395647e-03
## ASV1890     -3.772689e-03 -3.920554e-03 -4.072926e-03 -4.229842e-03
## ASV2898      6.379397e-03  6.655220e-03  6.941763e-03  7.239344e-03
## ASV8328      9.043586e-04  9.677049e-04  1.035694e-03  1.108662e-03
## ASV0709     -7.148663e-03 -7.463404e-03 -7.790845e-03 -8.131397e-03
## ASV0856      6.047602e-03  6.331741e-03  6.628975e-03  6.939877e-03
## ASV0909      1.833557e-03  1.933862e-03  2.039994e-03  2.152306e-03
## ASV0937     -4.250957e-03 -4.446260e-03 -4.650275e-03 -4.863376e-03
## ASV11390    -1.186724e-02 -1.235783e-02 -1.286572e-02 -1.339126e-02
## ASV11966     2.985430e-03  3.129406e-03  3.280302e-03  3.438439e-03
## ASV12990     2.090450e-03  2.179630e-03  2.272137e-03  2.368053e-03
## ASV14797     3.085110e-03  3.214996e-03  3.349614e-03  3.489077e-03
## ASV14904    -1.702826e-02 -1.773220e-02 -1.846093e-02 -1.921500e-02
## ASV15304     1.896354e-03  1.991909e-03  2.092372e-03  2.197992e-03
## ASV16696    -5.882533e-03 -6.125675e-03 -6.377380e-03 -6.637835e-03
## ASV1690      1.028562e-02  1.076984e-02  1.127632e-02  1.180600e-02
## ASV2029      7.018081e-03  7.325747e-03  7.645777e-03  7.978578e-03
## ASV2834      8.883578e-03  9.287592e-03  9.709110e-03  1.014881e-02
## ASV4003      7.431436e-03  7.791325e-03  8.168801e-03  8.564725e-03
## ASV4064      4.226573e-03  4.420553e-03  4.623073e-03  4.834475e-03
## ASV4294      2.624691e-03  2.757122e-03  2.896428e-03  3.042976e-03
## ASV4609      2.369895e-03  2.473065e-03  2.580300e-03  2.691725e-03
## ASV6283     -5.499794e-03 -5.727181e-03 -5.962584e-03 -6.206179e-03
## ASV6491     -7.880920e-03 -8.206670e-03 -8.543896e-03 -8.892851e-03
## ASV7453      3.967135e-03  4.159760e-03  4.361746e-03  4.573537e-03
## ASV7959      1.475377e-03  1.555281e-03  1.639731e-03  1.728992e-03
## ASV8219      6.810063e-02  7.091533e-02  7.382921e-02  7.684444e-02
## ASV8547     -7.053266e-03 -7.344713e-03 -7.646423e-03 -7.958621e-03
## ASV9319      3.168085e-03  3.316312e-03  3.471326e-03  3.633421e-03
## ASV9382     -1.379876e-02 -1.436887e-02 -1.495905e-02 -1.556975e-02
## ASV11516    -9.214133e-03 -9.594728e-03 -9.988714e-03 -1.039638e-02
## ASV14377    -6.651420e-03 -6.926090e-03 -7.210418e-03 -7.504615e-03
## ASV1867      5.287868e-03  5.530636e-03  5.784129e-03  6.048783e-03
## ASV1895      2.581446e-03  2.686540e-03  2.795066e-03  2.907057e-03
## ASV3168      3.272637e-03  3.410166e-03  3.552634e-03  3.700145e-03
## ASV4449      1.826363e-02  1.907541e-02  1.992099e-02  2.080161e-02
## ASV6596      3.906338e-03  4.098618e-03  4.300535e-03  4.512580e-03
## ASV7492     -5.945419e-04 -6.039381e-04 -6.122784e-04 -6.194083e-04
## ASV9854     -1.415305e-03 -1.472578e-03 -1.531787e-03 -1.592972e-03
## ASV6296      1.115812e-01  1.161876e-01  1.209560e-01  1.258898e-01
## ASV4201      6.521349e-04  6.994115e-04  7.502424e-04  8.048893e-04
## ASV0552      3.653736e-03  3.820539e-03  3.994626e-03  4.176287e-03
## ASV3671     -2.409198e-03 -2.514927e-03 -2.625001e-03 -2.739582e-03
## ASV3529     -5.516475e-04 -5.626938e-04 -5.731022e-04 -5.827681e-04
## ASV1060      9.817356e-04  1.028344e-03  1.077164e-03  1.128301e-03
## ASV0239     -1.276916e-03 -1.328669e-03 -1.382129e-03 -1.437320e-03
## ASV5711     -5.873267e-03 -6.127825e-03 -6.392429e-03 -6.667402e-03
## ASV4152     -8.384306e-03 -8.761287e-03 -9.154297e-03 -9.563943e-03
## ASV1461      4.130732e-03  4.299885e-03  4.474757e-03  4.655440e-03
## ASV2877      2.153369e-03  2.242940e-03  2.335656e-03  2.431579e-03
## ASV0012      3.783532e-04  3.952769e-04  4.129118e-04  4.312841e-04
## ASV9823      5.042189e-04  5.208055e-04  5.375308e-04  5.543478e-04
## ASV0008      4.027245e-04  4.205878e-04  4.391893e-04  4.585554e-04
## ASV7832     -4.945283e-03 -5.169447e-03 -5.403353e-03 -5.647394e-03
## ASV1915     -6.169017e-04 -6.431504e-04 -6.704281e-04 -6.987723e-04
## ASV0055     -4.503185e-04 -4.730571e-04 -4.969814e-04 -5.221548e-04
## ASV0032      1.921833e-04  1.991696e-04  2.063097e-04  2.135976e-04
## ASV2977     -6.947567e-03 -7.258386e-03 -7.582277e-03 -7.919724e-03
## ASV0466      5.467627e-03  5.691944e-03  5.923897e-03  6.163613e-03
## ASV3866      3.851627e-03  4.029978e-03  4.216358e-03  4.411109e-03
## ASV0040      1.383518e-03  1.446215e-03  1.511614e-03  1.579821e-03
## ASV0496     -3.759648e-04 -4.012453e-04 -4.283343e-04 -4.573618e-04
## ASV0052      1.162092e-03  1.214842e-03  1.269871e-03  1.327270e-03
## ASV3828     -3.948315e-03 -4.110631e-03 -4.278589e-03 -4.452307e-03
## ASV1930      2.044150e-03  2.131373e-03  2.221849e-03  2.315659e-03
## ASV2126      3.507532e-03  3.661443e-03  3.821550e-03  3.988056e-03
## ASV0793      4.356636e-03  4.557173e-03  4.766618e-03  4.985338e-03
## ASV0299     -8.754332e-05 -9.199862e-05 -9.671764e-05 -1.017208e-04
## ASV0208      3.132383e-03  3.274279e-03  3.422295e-03  3.576670e-03
## ASV0511     -1.252711e-03 -1.303110e-03 -1.355119e-03 -1.408755e-03
## ASV1123     -3.802924e-03 -3.958357e-03 -4.119054e-03 -4.285105e-03
## ASV0099      1.229154e-04  1.295298e-04  1.365315e-04  1.439455e-04
## ASV0752     -2.256808e-03 -2.363694e-03 -2.475581e-03 -2.592695e-03
## ASV0883      3.090985e-03  3.236564e-03  3.388879e-03  3.548228e-03
## ASV0683      4.027314e-03  4.214686e-03  4.410551e-03  4.615273e-03
## ASV4117     -6.369526e-03 -6.657977e-03 -6.958910e-03 -7.272823e-03
## ASV2172      3.915955e-04  4.054528e-04  4.195562e-04  4.338845e-04
## ASV0330     -1.193698e-03 -1.248360e-03 -1.305431e-03 -1.365010e-03
## ASV0728      5.857982e-03  6.119122e-03  6.391098e-03  6.674289e-03
## ASV0499      1.569340e-03  1.642747e-03  1.719521e-03  1.799812e-03
## ASV0120     -2.600156e-03 -2.716413e-03 -2.837523e-03 -2.963659e-03
## ASV1446      1.910967e-03  1.981546e-03  2.053804e-03  2.127698e-03
## ASV17171    -5.018132e-03 -5.241959e-03 -5.475195e-03 -5.718195e-03
## ASV0533      3.839717e-04  4.029058e-04  4.227898e-04  4.436716e-04
## ASV2495     -1.278274e-03 -1.344138e-03 -1.413584e-03 -1.486819e-03
## ASV5582      2.246411e-03  2.333440e-03  2.422945e-03  2.514918e-03
## ASV1488      8.758649e-04  9.129873e-04  9.514683e-04  9.913378e-04
## ASV0682      1.145568e-03  1.199525e-03  1.255986e-03  1.315061e-03
## ASV0068     -1.972356e-03 -2.061110e-03 -2.153621e-03 -2.250026e-03
## ASV1987     -4.981544e-03 -5.218471e-03 -5.466566e-03 -5.726341e-03
## ASV0035     -3.945980e-04 -4.178249e-04 -4.425473e-04 -4.688684e-04
## ASV7192     -3.027109e-03 -3.158542e-03 -3.295158e-03 -3.437117e-03
## ASV0873     -8.898839e-04 -1.024612e-03 -1.172825e-03 -1.335619e-03
## ASV4749     -1.935538e-04 -2.191260e-04 -2.472786e-04 -2.782365e-04
## ASV2174      2.060261e-03  2.141615e-03  2.225422e-03  2.311689e-03
## ASV1476     -2.201404e-03 -2.304988e-03 -2.413408e-03 -2.526889e-03
## ASV0740     -6.244548e-03 -6.537019e-03 -6.842944e-03 -7.162918e-03
## ASV0170     -1.210474e-03 -1.265081e-03 -1.322021e-03 -1.381382e-03
## ASV2466     -5.520254e-03 -5.769682e-03 -6.029842e-03 -6.301156e-03
## ASV1709      1.996936e-03  2.082503e-03  2.171429e-03  2.263831e-03
## ASV6170     -8.692610e-03 -9.094052e-03 -9.513473e-03 -9.951628e-03
## ASV3673      4.283839e-03  4.484362e-03  4.694096e-03  4.913446e-03
## ASV1745     -1.123678e-03 -1.178826e-03 -1.236724e-03 -1.297512e-03
##                                                                    
## (Intercept)  3.505534e-02  3.661815e-02  3.824567e-02  3.994015e-02
## ASV1236      6.792624e-03  7.079326e-03  7.376630e-03  7.684813e-03
## ASV0421      8.683494e-04  9.167376e-04  9.679650e-04  1.022199e-03
## ASV0691     -5.103527e-03 -5.296051e-03 -5.493710e-03 -5.696469e-03
## ASV0899      5.899311e-03  6.149431e-03  6.408788e-03  6.677607e-03
## ASV1004      1.362156e-02  1.419872e-02  1.479730e-02  1.541787e-02
## ASV1041     -5.583745e-03 -5.817608e-03 -6.059804e-03 -6.310501e-03
## ASV1058      8.494867e-03  8.854069e-03  9.226577e-03  9.612737e-03
## ASV12542     3.257624e-03  3.390874e-03  3.528677e-03  3.671120e-03
## ASV1294      7.911766e-03  8.247058e-03  8.594836e-03  8.955430e-03
## ASV13113     2.764178e-03  2.896589e-03  3.035348e-03  3.180755e-03
## ASV1318      7.885287e-03  8.218862e-03  8.564785e-03  8.923372e-03
## ASV2269     -1.362893e-02 -1.420202e-02 -1.479593e-02 -1.541115e-02
## ASV2542      6.838774e-03  7.151441e-03  7.477853e-03  7.818569e-03
## ASV2660     -5.408756e-03 -5.634434e-03 -5.868175e-03 -6.110158e-03
## ASV2737      1.835354e-03  1.907450e-03  1.981764e-03  2.058317e-03
## ASV2840      7.124632e-03  7.410924e-03  7.706422e-03  8.011230e-03
## ASV3053      3.670780e-02  3.821508e-02  3.977435e-02  4.138662e-02
## ASV3077      2.346413e-03  2.443466e-03  2.543943e-03  2.647923e-03
## ASV3134      4.378274e-03  4.583818e-03  4.798871e-03  5.023860e-03
## ASV3140      5.821423e-03  6.080539e-03  6.350392e-03  6.631358e-03
## ASV3579      2.151369e-03  2.258080e-03  2.370189e-03  2.487971e-03
## ASV6119     -3.729050e-03 -3.885812e-03 -4.048266e-03 -4.216544e-03
## ASV7557     -7.575937e-03 -7.894310e-03 -8.224234e-03 -8.565977e-03
## ASV8422      1.875329e-03  1.952635e-03  2.032646e-03  2.115422e-03
## ASV1086     -2.801074e-04 -2.901575e-04 -3.004406e-04 -3.109533e-04
## ASV1310      3.634774e-03  3.788108e-03  3.947070e-03  4.111799e-03
## ASV15750    -4.793906e-04 -4.976868e-04 -5.164723e-04 -5.357409e-04
## ASV16905    -1.557862e-03 -1.623330e-03 -1.691173e-03 -1.761447e-03
## ASV2033      6.900948e-03  7.220346e-03  7.554045e-03  7.902637e-03
## ASV2089      3.286770e-03  3.425101e-03  3.568468e-03  3.716990e-03
## ASV2127      1.068467e-02  1.113578e-02  1.160352e-02  1.208831e-02
## ASV2725      8.482114e-03  8.832273e-03  9.194637e-03  9.569453e-03
## ASV2804     -3.224541e-03 -3.360037e-03 -3.500448e-03 -3.645889e-03
## ASV3075      7.191110e-03  7.508419e-03  7.838793e-03  8.182704e-03
## ASV3327      1.006847e-02  1.052635e-02  1.100406e-02  1.150240e-02
## ASV3342      8.623941e-03  9.012835e-03  9.418335e-03  9.841073e-03
## ASV3532     -9.458968e-03 -9.879103e-03 -1.031667e-02 -1.077228e-02
## ASV3600      4.407380e-03  4.604366e-03  4.809622e-03  5.023453e-03
## ASV4013      8.124876e-03  8.476624e-03  8.842107e-03  9.221741e-03
## ASV4136      8.530173e-03  8.884314e-03  9.251052e-03  9.630673e-03
## ASV4195      3.290609e-02  3.428835e-02  3.572072e-02  3.720437e-02
## ASV4407     -1.271041e-02 -1.324415e-02 -1.379722e-02 -1.437008e-02
## ASV4717      2.146612e-03  2.229330e-03  2.314438e-03  2.401945e-03
## ASV6794      5.199639e-03  5.410605e-03  5.628675e-03  5.853980e-03
## ASV8324     -6.522037e-03 -6.795910e-03 -7.079704e-03 -7.373648e-03
## ASV8981     -1.157939e-04 -1.152558e-04 -1.141905e-04 -1.125357e-04
## ASV9859      2.442847e-03  2.566847e-03  2.697392e-03  2.834840e-03
## ASV0936      6.504619e-03  6.797957e-03  7.103757e-03  7.422480e-03
## ASV12683    -2.166102e-05 -2.416516e-05 -2.688405e-05 -2.983122e-05
## ASV1293      4.226989e-03  4.404136e-03  4.587690e-03  4.777802e-03
## ASV13055    -6.627816e-05 -6.511048e-05 -6.352999e-05 -6.149073e-05
## ASV17063    -3.380809e-03 -3.522621e-03 -3.669559e-03 -3.821740e-03
## ASV2228      2.756365e-03  2.871946e-03  2.991701e-03  3.115726e-03
## ASV2769      4.847533e-04  5.109071e-04  5.385263e-04  5.676924e-04
## ASV2803      2.930555e-03  3.047585e-03  3.168354e-03  3.292906e-03
## ASV2896      2.467391e-03  2.580528e-03  2.698702e-03  2.822131e-03
## ASV3062      3.053044e-03  3.201093e-03  3.356350e-03  3.519162e-03
## ASV3107      4.574660e-03  4.781483e-03  4.997210e-03  5.222188e-03
## ASV3265      6.038973e-03  6.291001e-03  6.552039e-03  6.822287e-03
## ASV3666      5.274137e-05  5.422257e-05  5.567944e-05  5.710264e-05
## ASV4497      2.089821e-03  2.178789e-03  2.271104e-03  2.366854e-03
## ASV6914     -3.436204e-04 -3.617853e-04 -3.809510e-04 -4.011729e-04
## ASV0576     -7.060336e-03 -7.338595e-03 -7.625409e-03 -7.920850e-03
## ASV0673      8.083393e-03  8.431319e-03  8.792642e-03  9.167752e-03
## ASV0772      3.769848e-03  3.934257e-03  4.105219e-03  4.282947e-03
## ASV0862      4.928330e-04  5.287431e-04  5.673217e-04  6.087561e-04
## ASV0898      3.012530e-03  3.153157e-03  3.300160e-03  3.453807e-03
## ASV0910      3.439534e-03  3.596157e-03  3.759604e-03  3.930149e-03
## ASV0964     -2.688158e-03 -2.796136e-03 -2.907600e-03 -3.022592e-03
## ASV10059     2.492971e-03  2.611523e-03  2.735670e-03  2.865667e-03
## ASV10263    -5.154746e-03 -5.371409e-03 -5.595945e-03 -5.828537e-03
## ASV1088      6.102593e-03  6.377455e-03  6.664108e-03  6.963018e-03
## ASV1101      7.356683e-03  7.664487e-03  7.983353e-03  8.313531e-03
## ASV1183      1.989088e-03  2.077324e-03  2.169203e-03  2.264854e-03
## ASV11956     1.838393e-03  1.910426e-03  1.984645e-03  2.061067e-03
## ASV12774     6.906142e-05  6.742433e-05  6.531345e-05  6.267885e-05
## ASV1321      8.920122e-03  9.330656e-03  9.759439e-03  1.020722e-02
## ASV13793    -3.553750e-03 -3.703089e-03 -3.857850e-03 -4.018161e-03
## ASV14482     2.130490e-04  2.206434e-04  2.284233e-04  2.363890e-04
## ASV15483     1.505643e-03  1.573859e-03  1.645006e-03  1.719197e-03
## ASV2062      6.882843e-03  7.180147e-03  7.489043e-03  7.809886e-03
## ASV2132      5.719622e-03  5.977749e-03  6.246897e-03  6.527480e-03
## ASV2413      5.280816e-03  5.504395e-03  5.736302e-03  5.976761e-03
## ASV2490      1.604647e-02  1.670215e-02  1.738014e-02  1.808084e-02
## ASV2594      2.073874e-03  2.166555e-03  2.263170e-03  2.363873e-03
## ASV2822     -9.382437e-03 -9.777059e-03 -1.018605e-02 -1.060974e-02
## ASV2863      9.930786e-03  1.034324e-02  1.077036e-02  1.121249e-02
## ASV2910      3.648885e-03  3.801992e-03  3.960663e-03  4.125030e-03
## ASV2980      4.122351e-03  4.301020e-03  4.486687e-03  4.679567e-03
## ASV3307      7.462104e-03  7.775745e-03  8.100784e-03  8.437489e-03
## ASV3474      5.136196e-03  5.375665e-03  5.626027e-03  5.887750e-03
## ASV3502      5.274843e-03  5.507657e-03  5.749980e-03  6.002141e-03
## ASV4236      7.516636e-03  7.820351e-03  8.134030e-03  8.457810e-03
## ASV4842     -8.502338e-04 -8.890805e-04 -9.295423e-04 -9.716659e-04
## ASV4894     -3.555721e-03 -3.705260e-03 -3.860242e-03 -4.020796e-03
## ASV5290      2.896298e-03  3.026279e-03  3.161736e-03  3.302871e-03
## ASV5501      1.760073e-03  1.838143e-03  1.919485e-03  2.004225e-03
## ASV5795      1.949814e-03  2.037746e-03  2.129425e-03  2.224993e-03
## ASV5987     -9.933688e-03 -1.035162e-02 -1.078479e-02 -1.123355e-02
## ASV6267     -1.119046e-02 -1.166111e-02 -1.214890e-02 -1.265424e-02
## ASV6862      4.447360e-03  4.629576e-03  4.818056e-03  5.012925e-03
## ASV7145      1.946817e-03  2.024942e-03  2.105666e-03  2.189041e-03
## ASV7673     -3.555415e-03 -3.704938e-03 -3.859904e-03 -4.020444e-03
## ASV7789      1.892861e-03  1.987680e-03  2.087380e-03  2.192215e-03
## ASV7809      1.689203e-04  1.816486e-04  1.953474e-04  2.100865e-04
## ASV8002     -4.490324e-03 -4.679181e-03 -4.874919e-03 -5.077700e-03
## ASV8205      1.924061e-03  2.010091e-03  2.099739e-03  2.193141e-03
## ASV9155     -1.127880e-03 -1.173712e-03 -1.221065e-03 -1.269960e-03
## ASV9221      5.483244e-04  5.815618e-04  6.169566e-04  6.546517e-04
## ASV9311     -7.202572e-03 -7.505485e-03 -7.819434e-03 -8.144682e-03
## ASV9557     -4.921178e-03 -5.128076e-03 -5.342506e-03 -5.564647e-03
## ASV9936     -9.921727e-03 -1.033872e-02 -1.077089e-02 -1.121858e-02
## ASV1445      6.170723e-03  6.446655e-03  6.734154e-03  7.033640e-03
## ASV4232      2.395435e-03  2.509787e-03  2.629621e-03  2.755203e-03
## ASV6479      9.352037e-04  9.888966e-04  1.045876e-03  1.106350e-03
## ASV0142     -4.262114e-03 -4.439568e-03 -4.623353e-03 -4.813611e-03
## ASV0378      2.039311e-03  2.136300e-03  2.237857e-03  2.344187e-03
## ASV1122      5.995133e-03  6.265842e-03  6.548132e-03  6.842445e-03
## ASV0123     -3.759781e-03 -3.915848e-03 -4.077441e-03 -4.244678e-03
## ASV2064      1.877919e-03  1.950332e-03  2.024775e-03  2.101236e-03
## ASV4459     -2.504246e-04 -2.586912e-04 -2.670794e-04 -2.755792e-04
## ASV0448      1.631846e-03  1.709571e-03  1.790964e-03  1.876191e-03
## ASV0397      3.482371e-03  3.634719e-03  3.793161e-03  3.957892e-03
## ASV0485      4.018942e-03  4.191554e-03  4.370809e-03  4.556903e-03
## ASV1566      5.952979e-03  6.212316e-03  6.481925e-03  6.762129e-03
## ASV1365      5.115976e-03  5.342491e-03  5.578266e-03  5.823613e-03
## ASV1065      7.262939e-03  7.583849e-03  7.917878e-03  8.265475e-03
## ASV0722     -3.877469e-04 -4.059663e-04 -4.250434e-04 -4.450198e-04
## ASV12660    -4.066426e-03 -4.234389e-03 -4.408252e-03 -4.588141e-03
## ASV0223      1.113073e-03  1.161251e-03  1.211325e-03  1.263355e-03
## ASV0229      1.729031e-03  1.807446e-03  1.889256e-03  1.974593e-03
## ASV0877      6.796606e-04  7.048711e-04  7.306325e-04  7.569146e-04
## ASV0983      3.976191e-03  4.145324e-03  4.320797e-03  4.502779e-03
## ASV0626      5.133567e-04  5.451075e-04  5.789147e-04  6.149079e-04
## ASV4146      1.923542e-04  1.998812e-04  2.075693e-04  2.154026e-04
## ASV4175     -5.002754e-03 -5.227699e-03 -5.462176e-03 -5.706539e-03
## ASV2082     -2.410747e-03 -2.538139e-03 -2.672638e-03 -2.814660e-03
## ASV2272      2.376396e-03  2.482711e-03  2.593517e-03  2.708983e-03
## ASV2245     -3.583527e-03 -3.745874e-03 -3.915197e-03 -4.091764e-03
## ASV0590     -2.317177e-03 -2.444245e-03 -2.578698e-03 -2.720977e-03
## ASV0217      2.982350e-04  3.246979e-04  3.533796e-04  3.844486e-04
## ASV0416      2.558356e-03  2.655263e-03  2.754740e-03  2.856757e-03
## ASV1056      3.493287e-03  3.654800e-03  3.823525e-03  3.999759e-03
## ASV7777     -4.855105e-03 -5.071951e-03 -5.297903e-03 -5.533299e-03
## ASV0455      8.670755e-04  9.052457e-04  9.449579e-04  9.862623e-04
## ASV0604      2.315490e-03  2.424363e-03  2.538248e-03  2.657360e-03
## ASV6100     -3.369320e-03 -3.522648e-03 -3.682667e-03 -3.849647e-03
## ASV11359    -7.190318e-03 -7.510972e-03 -7.844969e-03 -8.192784e-03
## ASV6604      1.015598e-03  1.063056e-03  1.112677e-03  1.164554e-03
## ASV5004     -2.547352e-03 -2.659865e-03 -2.776993e-03 -2.898897e-03
## ASV1483     -1.092775e-03 -1.140474e-03 -1.190071e-03 -1.241626e-03
## ASV9773     -3.249761e-03 -3.396079e-03 -3.548637e-03 -3.707672e-03
## ASV4059      9.353058e-05  1.078286e-04  1.235956e-04  1.409560e-04
## ASV1193      3.887978e-03  4.058435e-03  4.235746e-03  4.420136e-03
## ASV4610     -4.960724e-04 -5.045677e-04 -5.123293e-04 -5.192522e-04
## ASV0742     -2.705923e-04 -2.710637e-04 -2.705882e-04 -2.690569e-04
## ASV1502     -2.384067e-04 -2.562254e-04 -2.753981e-04 -2.960223e-04
## ASV0195      5.627328e-05  5.440310e-05  5.209448e-05  4.930399e-05
## ASV1213      2.643520e-03  2.748295e-03  2.856331e-03  2.967659e-03
## ASV1648     -3.023171e-03 -3.160457e-03 -3.303720e-03 -3.453203e-03
## ASV6984     -2.830514e-03 -2.959313e-03 -3.093749e-03 -3.234054e-03
## ASV0396     -1.164405e-04 -1.168378e-04 -1.168742e-04 -1.165111e-04
## ASV4297      3.873762e-03  4.031933e-03  4.195450e-03  4.364404e-03
## ASV2622      6.080755e-03  6.337697e-03  6.604146e-03  6.880347e-03
## ASV3512      2.536853e-03  2.664248e-03  2.798246e-03  2.939201e-03
## ASV2411      4.298027e-03  4.497884e-03  4.706793e-03  4.925141e-03
## ASV2291     -2.022399e-03 -2.135255e-03 -2.254779e-03 -2.381371e-03
## ASV0807      5.727701e-03  5.978870e-03  6.240115e-03  6.511762e-03
## ASV1292      1.315724e-03  1.365720e-03  1.417073e-03  1.469777e-03
## ASV1035      5.154098e-03  5.369164e-03  5.592002e-03  5.822804e-03
## ASV0070      8.802698e-05  9.686639e-05  1.065083e-04  1.170187e-04
## ASV0255      4.739007e-04  4.918451e-04  5.102417e-04  5.290790e-04
## ASV0057     -1.394426e-03 -1.449715e-03 -1.506714e-03 -1.565435e-03
## ASV0077     -2.797945e-04 -2.889841e-04 -2.982757e-04 -3.076503e-04
## ASV0625      2.952250e-03  3.073441e-03  3.198793e-03  3.328384e-03
## ASV2464      2.004589e-02  2.086540e-02  2.171304e-02  2.258938e-02
## ASV1315      5.616269e-03  5.879257e-03  6.154305e-03  6.441939e-03
## ASV2673      4.821929e-03  5.048234e-03  5.284963e-03  5.532576e-03
## ASV2161      2.035674e-03  2.130895e-03  2.230493e-03  2.334661e-03
## ASV0337     -1.149234e-03 -1.201114e-03 -1.255211e-03 -1.311609e-03
## ASV7680     -7.515486e-03 -7.856594e-03 -8.212455e-03 -8.583645e-03
## ASV0611      4.202095e-03  4.393416e-03  4.593080e-03  4.801421e-03
## ASV3118     -4.432614e-03 -4.642058e-03 -4.861253e-03 -5.090634e-03
## ASV1284      1.252881e-03  1.275755e-03  1.296702e-03  1.315411e-03
## ASV0889      3.100492e-03  3.233080e-03  3.370738e-03  3.513617e-03
## ASV4649     -1.577072e-03 -1.647145e-03 -1.720124e-03 -1.796115e-03
## ASV1108     -3.345125e-03 -3.506472e-03 -3.675630e-03 -3.852974e-03
## ASV0738      1.913097e-03  2.012439e-03  2.117165e-03  2.227577e-03
## ASV0473     -4.128847e-04 -4.366505e-04 -4.618301e-04 -4.885039e-04
## ASV0598     -1.001691e-03 -1.056331e-03 -1.114147e-03 -1.175332e-03
## ASV0429      2.276973e-03  2.371406e-03  2.469141e-03  2.570241e-03
## ASV1549      4.453343e-03  4.662820e-03  4.881988e-03  5.111275e-03
## ASV1203      3.378974e-03  3.524074e-03  3.674736e-03  3.831117e-03
## ASV4532      1.265725e-04  1.300383e-04  1.334883e-04  1.369126e-04
## ASV0274      6.265726e-04  6.576018e-04  6.901697e-04  7.243484e-04
## ASV0163     -2.559620e-03 -2.664199e-03 -2.772351e-03 -2.884144e-03
## ASV1298      2.626606e-04  2.716422e-04  2.808136e-04  2.901740e-04
## ASV9424     -5.845743e-03 -6.113387e-03 -6.392845e-03 -6.684604e-03
## ASV0412      5.840008e-03  6.088523e-03  6.346397e-03  6.613886e-03
## ASV0284      1.152930e-03  1.194459e-03  1.236871e-03  1.280126e-03
## ASV0620     -1.308691e-03 -1.376569e-03 -1.448100e-03 -1.523486e-03
## ASV0153     -5.951960e-03 -6.231612e-03 -6.524152e-03 -6.830145e-03
## ASV0498      2.068872e-03  2.162617e-03  2.260361e-03  2.362250e-03
## ASV0097      1.169219e-03  1.224188e-03  1.281700e-03  1.341869e-03
## ASV0104     -8.002695e-03 -8.350944e-03 -8.712928e-03 -9.089070e-03
## ASV1282      2.701122e-03  2.812146e-03  2.926938e-03  3.045557e-03
## ASV3883     -2.320038e-03 -2.434437e-03 -2.554528e-03 -2.680591e-03
## ASV0801      1.102858e-03  1.152842e-03  1.204978e-03  1.259349e-03
## ASV1611     -5.271281e-03 -5.515766e-03 -5.771285e-03 -6.038306e-03
## ASV0227     -1.027253e-03 -1.082769e-03 -1.141428e-03 -1.203411e-03
## ASV0833      1.770209e-03  1.849867e-03  1.932896e-03  2.019418e-03
## ASV0718      7.900372e-03  8.254279e-03  8.623104e-03  9.007402e-03
## ASV1139      8.972866e-04  9.244160e-04  9.515454e-04  9.785787e-04
## ASV0766     -1.155750e-03 -1.212908e-03 -1.272916e-03 -1.335912e-03
## ASV2091      6.203531e-03  6.458483e-03  6.722193e-03  6.994822e-03
## ASV1238     -5.937756e-03 -6.210847e-03 -6.496153e-03 -6.794197e-03
## ASV9193     -6.677025e-04 -7.088730e-04 -7.527885e-04 -7.996391e-04
## ASV0290      7.647170e-04  7.914158e-04  8.186295e-04  8.463331e-04
## ASV0231      2.297962e-03  2.395578e-03  2.496840e-03  2.601842e-03
## ASV0185      1.463922e-03  1.539551e-03  1.619253e-03  1.703253e-03
## ASV2330      2.574812e-03  2.677898e-03  2.784283e-03  2.894009e-03
## ASV3119     -1.319572e-03 -1.387097e-03 -1.458200e-03 -1.533075e-03
## ASV2368     -3.087000e-03 -3.233139e-03 -3.386169e-03 -3.546416e-03
## ASV0122     -1.437269e-03 -1.499325e-03 -1.563797e-03 -1.630756e-03
## ASV1044      3.799094e-03  3.975435e-03  4.159750e-03  4.352379e-03
## ASV0160     -1.501312e-03 -1.561717e-03 -1.624092e-03 -1.688465e-03
## ASV0326      4.154600e-04  4.341565e-04  4.536357e-04  4.739243e-04
## ASV1388      7.472641e-03  7.796834e-03  8.133732e-03  8.483723e-03
## ASV0792      5.466586e-03  5.695466e-03  5.932601e-03  6.178180e-03
## ASV0036     -1.786026e-03 -1.869954e-03 -1.957742e-03 -2.049555e-03
## ASV2125      5.363296e-03  5.598281e-03  5.842681e-03  6.096799e-03
## ASV1075     -8.131042e-05 -8.500744e-05 -8.887940e-05 -9.293641e-05
## ASV0390      2.950484e-03  3.089512e-03  3.235024e-03  3.387314e-03
## ASV3790     -4.120543e-03 -4.307302e-03 -4.502121e-03 -4.705315e-03
## ASV1535     -1.251207e-03 -1.314583e-03 -1.381265e-03 -1.451427e-03
## ASV0263      5.004716e-03  5.227056e-03  5.458598e-03  5.699666e-03
## ASV0675      7.625641e-03  7.975732e-03  8.341311e-03  8.723013e-03
## ASV3348      6.375571e-04  6.688542e-04  7.017005e-04  7.361714e-04
## ASV0058     -2.205931e-03 -2.301179e-03 -2.400119e-03 -2.502860e-03
## ASV4142      3.050277e-03  3.177116e-03  3.308425e-03  3.444297e-03
## ASV0059     -1.769384e-03 -1.844958e-03 -1.923388e-03 -2.004750e-03
## ASV0013     -3.191028e-03 -3.332328e-03 -3.479429e-03 -3.632531e-03
## ASV0033     -1.549264e-03 -1.621741e-03 -1.697527e-03 -1.776763e-03
## ASV4354     -1.883389e-03 -1.967388e-03 -2.054931e-03 -2.146154e-03
## ASV0022     -1.307575e-03 -1.368685e-03 -1.432584e-03 -1.499391e-03
## ASV0134     -1.269329e-03 -1.331390e-03 -1.396520e-03 -1.464869e-03
## ASV0415      2.195359e-04  2.317471e-04  2.446517e-04  2.582867e-04
## ASV10103    -7.207368e-03 -7.538471e-03 -7.884240e-03 -8.245276e-03
## ASV1613      5.184902e-03  5.402091e-03  5.627091e-03  5.860073e-03
## ASV0135     -6.522902e-04 -6.780510e-04 -7.045967e-04 -7.319314e-04
## ASV0469     -6.750999e-03 -7.040727e-03 -7.341609e-03 -7.653975e-03
## ASV0471      4.154723e-03  4.337950e-03  4.528639e-03  4.727044e-03
## ASV0451     -7.618939e-04 -8.044912e-04 -8.496076e-04 -8.973951e-04
## ASV0747      2.382682e-03  2.489720e-03  2.601278e-03  2.717519e-03
## ASV1314     -2.446907e-03 -2.562934e-03 -2.684433e-03 -2.811658e-03
## ASV0425     -8.254506e-03 -8.597119e-03 -8.951837e-03 -9.318916e-03
## ASV0559     -2.085918e-03 -2.177730e-03 -2.273327e-03 -2.372853e-03
## ASV0148     -4.184310e-04 -4.307556e-04 -4.430312e-04 -4.552073e-04
## ASV0129      5.946200e-04  6.327225e-04  6.734477e-04  7.169803e-04
## ASV1072      5.250076e-04  5.441421e-04  5.636881e-04  5.836259e-04
## ASV2390      4.179103e-03  4.346628e-03  4.519468e-03  4.697670e-03
## ASV0548      2.853493e-03  2.978703e-03  3.108948e-03  3.244391e-03
## ASV0168     -1.449606e-03 -1.511556e-03 -1.575860e-03 -1.642585e-03
## ASV0066     -1.640442e-03 -1.711287e-03 -1.784872e-03 -1.861275e-03
## ASV0468     -8.801354e-04 -9.194692e-04 -9.604577e-04 -1.003163e-03
## ASV0172     -4.623285e-04 -4.790094e-04 -4.960383e-04 -5.133979e-04
## ASV0236      4.089384e-05  5.754311e-05  7.617694e-05  9.697453e-05
## ASV0250      2.455835e-03  2.578052e-03  2.706506e-03  2.841520e-03
## ASV0338      1.134836e-03  1.187855e-03  1.243253e-03  1.301123e-03
## ASV0450     -2.371202e-04 -2.509251e-04 -2.655884e-04 -2.811650e-04
## ASV0377      2.046081e-03  2.134127e-03  2.225561e-03  2.320479e-03
## ASV1022     -8.166224e-05 -8.448584e-05 -8.733594e-05 -9.020300e-05
## ASV6174     -6.031691e-05 -6.474680e-05 -6.953150e-05 -7.470006e-05
## ASV0786     -3.434224e-04 -3.645948e-04 -3.871307e-04 -4.111159e-04
## ASV0053     -2.244790e-03 -2.344880e-03 -2.449136e-03 -2.557707e-03
## ASV0697     -1.333142e-03 -1.389129e-03 -1.447167e-03 -1.507307e-03
## ASV0785      2.835608e-03  2.957793e-03  3.084697e-03  3.216459e-03
## ASV1967     -2.805353e-03 -2.925110e-03 -3.049439e-03 -3.178475e-03
## ASV0385      9.886048e-04  1.035611e-03  1.084807e-03  1.136290e-03
## ASV0295      2.114951e-04  2.255266e-04  2.405522e-04  2.566429e-04
## ASV0072     -2.184749e-03 -2.276740e-03 -2.372076e-03 -2.470836e-03
## ASV0157     -2.211770e-04 -2.239265e-04 -2.261513e-04 -2.277761e-04
## ASV0501      4.856946e-03  5.074581e-03  5.301359e-03  5.537610e-03
## ASV10729    -6.130441e-03 -6.408156e-03 -6.697832e-03 -6.999934e-03
## ASV1470      2.973938e-03  3.092098e-03  3.213931e-03  3.339468e-03
## ASV0050     -5.195176e-03 -5.419918e-03 -5.653408e-03 -5.895907e-03
## ASV0411     -1.208149e-03 -1.264417e-03 -1.323243e-03 -1.384738e-03
## ASV0549      1.928773e-03  2.017140e-03  2.109394e-03  2.205692e-03
## ASV0184      6.312122e-04  6.587359e-04  6.873699e-04  7.171535e-04
## ASV0705      1.233297e-03  1.285181e-03  1.338944e-03  1.394628e-03
## ASV1715      2.665252e-03  2.783822e-03  2.907306e-03  3.035877e-03
## ASV0603      4.240247e-04  4.439573e-04  4.648343e-04  4.867030e-04
## ASV0826      4.466645e-03  4.661752e-03  4.864645e-03  5.075576e-03
## ASV0034     -1.413859e-03 -1.473711e-03 -1.535775e-03 -1.600105e-03
## ASV0838      8.447150e-04  8.654535e-04  8.855064e-04  9.047079e-04
## ASV0614     -1.221783e-03 -1.275040e-03 -1.330417e-03 -1.387981e-03
## ASV0014     -3.247660e-03 -3.390211e-03 -3.538501e-03 -3.692718e-03
## ASV0585      2.506838e-04  2.495391e-04  2.472813e-04  2.437825e-04
## ASV0016     -3.392572e-03 -3.541478e-03 -3.696377e-03 -3.857467e-03
## ASV5394     -2.565435e-03 -2.680484e-03 -2.800381e-03 -2.925303e-03
## ASV0666      5.444748e-03  5.672238e-03  5.907901e-03  6.151923e-03
## ASV2085      1.097799e-03  1.125967e-03  1.153532e-03  1.180326e-03
## ASV0003     -2.312011e-03 -2.413341e-03 -2.518739e-03 -2.628335e-03
## ASV0346      1.198901e-03  1.255465e-03  1.314635e-03  1.376522e-03
## ASV0267      2.665938e-05  3.191109e-05  3.773288e-05  4.417344e-05
## ASV0353      1.889228e-03  1.976700e-03  2.068102e-03  2.163597e-03
## ASV2419      4.951828e-03  5.166089e-03  5.388719e-03  5.619972e-03
## ASV0447      2.774978e-03  2.903947e-03  3.038733e-03  3.179579e-03
## ASV0654      4.021473e-03  4.198442e-03  4.382566e-03  4.574080e-03
## ASV0151      5.804230e-04  6.109721e-04  6.432126e-04  6.772415e-04
## ASV0065     -1.546530e-03 -1.613507e-03 -1.683102e-03 -1.755393e-03
## ASV0527      3.816034e-03  3.982835e-03  4.156299e-03  4.336640e-03
## ASV4055     -6.373973e-04 -6.692600e-04 -7.027867e-04 -7.380709e-04
## ASV0166     -1.884494e-03 -1.963184e-03 -2.044693e-03 -2.129083e-03
## ASV0417     -7.498905e-04 -7.787703e-04 -8.084605e-04 -8.389575e-04
## ASV0078     -1.121557e-03 -1.168895e-03 -1.217960e-03 -1.268795e-03
## ASV0322     -1.720122e-04 -1.751962e-04 -1.780623e-04 -1.805527e-04
## ASV0156     -2.741515e-03 -2.865855e-03 -2.995581e-03 -3.130906e-03
## ASV0648     -5.970842e-03 -6.243486e-03 -6.528061e-03 -6.825046e-03
## ASV0407     -4.555248e-04 -4.772333e-04 -4.999763e-04 -5.238032e-04
## ASV2030     -9.719582e-04 -1.014201e-03 -1.058199e-03 -1.104027e-03
## ASV0300      7.234449e-04  7.576587e-04  7.934647e-04  8.309336e-04
## ASV1150      1.723356e-04  1.815364e-04  1.912467e-04  2.014942e-04
## ASV0958      2.240196e-03  2.346839e-03  2.458540e-03  2.575538e-03
## ASV0216     -2.379936e-03 -2.482429e-03 -2.588933e-03 -2.699579e-03
## ASV0446      3.679325e-03  3.847202e-03  4.022391e-03  4.205180e-03
## ASV0367     -2.393239e-03 -2.500552e-03 -2.612395e-03 -2.728935e-03
## ASV0200     -1.422002e-03 -1.485557e-03 -1.551770e-03 -1.620738e-03
## ASV0334     -7.062143e-04 -7.306170e-04 -7.554594e-04 -7.807146e-04
## ASV1311      8.776592e-04  9.105393e-04  9.442413e-04  9.787481e-04
## ASV0458      1.287315e-03  1.334552e-03  1.382908e-03  1.432355e-03
## ASV1371      2.357295e-04  2.475134e-04  2.598852e-04  2.728722e-04
## ASV0418      3.077528e-03  3.205023e-03  3.337013e-03  3.473594e-03
## ASV0004      4.444093e-04  4.626150e-04  4.814428e-04  5.009041e-04
## ASV1943      8.144870e-03  8.438473e-03  8.738877e-03  9.045941e-03
## ASV1495     -7.350725e-04 -7.792443e-04 -8.262675e-04 -8.763321e-04
## ASV0901     -2.721001e-03 -2.846795e-03 -2.978252e-03 -3.115612e-03
## ASV0628      1.362149e-03  1.415729e-03  1.470912e-03  1.527701e-03
## ASV0400      8.469761e-04  8.824066e-04  9.190964e-04  9.570701e-04
## ASV0116     -7.988368e-04 -8.356084e-04 -8.740189e-04 -9.141367e-04
## ASV0788      7.073190e-03  7.400126e-03  7.741749e-03  8.098683e-03
## ASV0117      5.312767e-04  5.569269e-04  5.838167e-04  6.120047e-04
## ASV3137     -1.596165e-04 -1.663317e-04 -1.732912e-04 -1.805004e-04
## ASV0001      4.753341e-04  4.945883e-04  5.144784e-04  5.350136e-04
## ASV1651      1.363283e-03  1.419549e-03  1.477778e-03  1.538007e-03
## ASV1692      5.882664e-03  6.153586e-03  6.436574e-03  6.732129e-03
## ASV0660      1.964299e-03  2.039707e-03  2.117171e-03  2.196669e-03
## ASV0508      9.692504e-05  1.004813e-04  1.041232e-04  1.078490e-04
## ASV1660     -1.229263e-03 -1.290556e-03 -1.354941e-03 -1.422571e-03
## ASV0233      1.794175e-03  1.874292e-03  1.957762e-03  2.044708e-03
## ASV1343     -3.343568e-03 -3.496853e-03 -3.656914e-03 -3.824028e-03
## ASV0209      1.591959e-03  1.656698e-03  1.723598e-03  1.792693e-03
## ASV0193     -1.867266e-03 -1.944147e-03 -2.023673e-03 -2.105889e-03
## ASV0357      7.947298e-04  8.365822e-04  8.807709e-04  9.274344e-04
## ASV0198      1.440567e-03  1.502538e-03  1.566905e-03  1.633740e-03
## ASV0007      4.154147e-04  4.317567e-04  4.485931e-04  4.659263e-04
## ASV1772     -6.056635e-04 -6.277738e-04 -6.503205e-04 -6.732698e-04
## ASV0009      3.394403e-04  3.523557e-04  3.656198e-04  3.792297e-04
## ASV0006     -4.053968e-04 -4.248246e-04 -4.451805e-04 -4.665080e-04
## ASV0011     -1.374619e-03 -1.437133e-03 -1.502360e-03 -1.570408e-03
## ASV0015      2.563449e-04  2.660672e-04  2.760472e-04  2.862820e-04
## ASV0017      2.891623e-04  3.001836e-04  3.115049e-04  3.231244e-04
## ASV0235     -1.274907e-03 -1.333385e-03 -1.394438e-03 -1.458171e-03
## ASV0382      9.965663e-04  1.041965e-03  1.089301e-03  1.138640e-03
## ASV2357      4.137921e-03  4.325829e-03  4.521888e-03  4.726421e-03
## ASV0567     -8.070995e-04 -8.444633e-04 -8.835313e-04 -9.243807e-04
## ASV0165      6.900085e-04  7.212655e-04  7.538635e-04  7.878534e-04
## ASV0005      9.875949e-04  1.030848e-03  1.075829e-03  1.122595e-03
## ASV0384     -7.582498e-05 -7.557359e-05 -7.498510e-05 -7.401847e-05
## ASV0002      1.812965e-04  1.888712e-04  1.967216e-04  2.048550e-04
## ASV3017      5.116413e-03  5.327875e-03  5.546703e-03  5.773040e-03
## ASV0091     -1.314518e-04 -1.371292e-04 -1.430370e-04 -1.491844e-04
## ASV0186     -1.997859e-03 -2.086148e-03 -2.178031e-03 -2.273628e-03
## ASV0370      1.047079e-03  1.091963e-03  1.138555e-03  1.186902e-03
## ASV0018      1.267791e-03  1.323612e-03  1.381691e-03  1.442104e-03
## ASV1377      1.247731e-02  1.300099e-02  1.354369e-02  1.410583e-02
## ASV0019      1.330860e-03  1.389553e-03  1.450631e-03  1.514172e-03
## ASV0023     -8.466915e-04 -8.856740e-04 -9.263857e-04 -9.688968e-04
## ASV2194      1.371871e-03  1.436334e-03  1.503791e-03  1.574379e-03
## ASV1155      5.216550e-03  5.435847e-03  5.663288e-03  5.899099e-03
## ASV0510     -1.354458e-03 -1.406243e-03 -1.459449e-03 -1.514070e-03
## ASV2371     -3.141485e-03 -3.273413e-03 -3.410197e-03 -3.551964e-03
## ASV0024     -1.052218e-03 -1.100437e-03 -1.150776e-03 -1.203321e-03
## ASV2452      3.091015e-03  3.213057e-03  3.338803e-03  3.468270e-03
## ASV2332     -9.073696e-03 -9.460647e-03 -9.862378e-03 -1.027933e-02
## ASV2591      2.572758e-03  2.703609e-03  2.841131e-03  2.985643e-03
## ASV0521      2.136362e-03  2.234155e-03  2.336250e-03  2.442824e-03
## ASV5542      2.044478e-03  2.137720e-03  2.234981e-03  2.336413e-03
## ASV0336     -2.930365e-04 -3.102766e-04 -3.285857e-04 -3.480303e-04
## ASV10102     3.774685e-03  3.946855e-03  4.126506e-03  4.313927e-03
## ASV16823    -5.554027e-03 -5.778264e-03 -6.009994e-03 -6.249354e-03
## ASV3104      2.872922e-02  2.988878e-02  3.108706e-02  3.232477e-02
## ASV0781      4.145398e-03  4.327540e-03  4.517045e-03  4.714158e-03
## ASV10899     2.616445e-03  2.751715e-03  2.894210e-03  3.044320e-03
## ASV11222    -9.771592e-03 -1.016596e-02 -1.057349e-02 -1.099444e-02
## ASV11327    -8.770564e-03 -9.124423e-03 -9.490092e-03 -9.867782e-03
## ASV12458    -9.765803e-03 -1.015970e-02 -1.056673e-02 -1.098713e-02
## ASV1636      5.625411e-03  5.863803e-03  6.111056e-03  6.367400e-03
## ASV1890     -4.391331e-03 -4.557416e-03 -4.728109e-03 -4.903414e-03
## ASV2898      7.548281e-03  7.868895e-03  8.201505e-03  8.546431e-03
## ASV8328      1.186966e-03  1.270988e-03  1.361133e-03  1.457832e-03
## ASV0709     -8.485478e-03 -8.853511e-03 -9.235921e-03 -9.633137e-03
## ASV0856      7.265044e-03  7.605094e-03  7.960669e-03  8.332432e-03
## ASV0909      2.271170e-03  2.396977e-03  2.530144e-03  2.671109e-03
## ASV0937     -5.085947e-03 -5.318389e-03 -5.561121e-03 -5.814576e-03
## ASV11390    -1.393483e-02 -1.449679e-02 -1.507749e-02 -1.567726e-02
## ASV11966     3.604154e-03  3.777793e-03  3.959721e-03  4.150314e-03
## ASV12990     2.467462e-03  2.570442e-03  2.677071e-03  2.787427e-03
## ASV14797     3.633495e-03  3.782976e-03  3.937623e-03  4.097539e-03
## ASV14904    -1.999495e-02 -2.080128e-02 -2.163450e-02 -2.249509e-02
## ASV15304     2.309031e-03  2.425760e-03  2.548466e-03  2.677443e-03
## ASV16696    -6.907223e-03 -7.185722e-03 -7.473505e-03 -7.770740e-03
## ASV1690      1.235987e-02  1.293894e-02  1.354426e-02  1.417692e-02
## ASV2029      8.324562e-03  8.684147e-03  9.057757e-03  9.445823e-03
## ASV2834      1.060741e-02  1.108560e-02  1.158415e-02  1.210379e-02
## ASV4003      8.980006e-03  9.415594e-03  9.872484e-03  1.035172e-02
## ASV4064      5.055111e-03  5.285344e-03  5.525546e-03  5.776101e-03
## ASV4294      3.197145e-03  3.359340e-03  3.529981e-03  3.709513e-03
## ASV4609      2.807469e-03  2.927660e-03  3.052429e-03  3.181908e-03
## ASV6283     -6.458139e-03 -6.718632e-03 -6.987821e-03 -7.265865e-03
## ASV6491     -9.253781e-03 -9.626926e-03 -1.001252e-02 -1.041079e-02
## ASV7453      4.795595e-03  5.028402e-03  5.272457e-03  5.528281e-03
## ASV7959      1.823342e-03  1.923075e-03  2.028500e-03  2.139944e-03
## ASV8219      7.996315e-02  8.318743e-02  8.651928e-02  8.996066e-02
## ASV8547     -8.281526e-03 -8.615353e-03 -8.960312e-03 -9.316601e-03
## ASV9319      3.802906e-03  3.980099e-03  4.165331e-03  4.358948e-03
## ASV9382     -1.620138e-02 -1.685438e-02 -1.752915e-02 -1.822608e-02
## ASV11516    -1.081803e-02 -1.125392e-02 -1.170433e-02 -1.216952e-02
## ASV14377    -7.808888e-03 -8.123438e-03 -8.448459e-03 -8.784140e-03
## ASV1867      6.325050e-03  6.613394e-03  6.914295e-03  7.228249e-03
## ASV1895      3.022540e-03  3.141533e-03  3.264044e-03  3.390069e-03
## ASV3168      3.852797e-03  4.010686e-03  4.173899e-03  4.342520e-03
## ASV4449      2.171853e-02  2.267305e-02  2.366652e-02  2.470030e-02
## ASV6596      4.735267e-03  4.969134e-03  5.214747e-03  5.472701e-03
## ASV7492     -6.251605e-04 -6.293542e-04 -6.317946e-04 -6.322723e-04
## ASV9854     -1.656170e-03 -1.721416e-03 -1.788746e-03 -1.858194e-03
## ASV6296      1.309925e-01  1.362675e-01  1.417179e-01  1.473470e-01
## ASV4201      8.636313e-04  9.267659e-04  9.946100e-04  1.067501e-03
## ASV0552      4.365817e-03  4.563524e-03  4.769721e-03  4.984734e-03
## ASV3671     -2.858837e-03 -2.982940e-03 -3.112074e-03 -3.246426e-03
## ASV3529     -5.915788e-04 -5.994135e-04 -6.061433e-04 -6.116303e-04
## ASV1060      1.181863e-03  1.237968e-03  1.296737e-03  1.358295e-03
## ASV0239     -1.494263e-03 -1.552979e-03 -1.613482e-03 -1.675786e-03
## ASV5711     -6.953072e-03 -7.249771e-03 -7.557838e-03 -7.877615e-03
## ASV4152     -9.990847e-03 -1.043565e-02 -1.089902e-02 -1.138162e-02
## ASV1461      4.842017e-03  5.034567e-03  5.233155e-03  5.437839e-03
## ASV2877      2.530766e-03  2.633269e-03  2.739139e-03  2.848420e-03
## ASV0012      4.504206e-04  4.703491e-04  4.910978e-04  5.126957e-04
## ASV9823      5.712036e-04  5.880383e-04  6.047852e-04  6.213696e-04
## ASV0008      4.787131e-04  4.996898e-04  5.215137e-04  5.442138e-04
## ASV7832     -5.901975e-03 -6.167518e-03 -6.444457e-03 -6.733243e-03
## ASV1915     -7.282219e-04 -7.588176e-04 -7.906022e-04 -8.236207e-04
## ASV0055     -5.486439e-04 -5.765190e-04 -6.058538e-04 -6.367259e-04
## ASV0032      2.210264e-04  2.285881e-04  2.362732e-04  2.440713e-04
## ASV2977     -8.271219e-03 -8.637271e-03 -9.018398e-03 -9.415132e-03
## ASV0466      6.411211e-03  6.666799e-03  6.930474e-03  7.202319e-03
## ASV3866      4.614586e-03  4.827156e-03  5.049201e-03  5.281116e-03
## ASV0040      1.650943e-03  1.725092e-03  1.802382e-03  1.882930e-03
## ASV0496     -4.884663e-04 -5.217954e-04 -5.575061e-04 -5.957652e-04
## ASV0052      1.387128e-03  1.449541e-03  1.514605e-03  1.582419e-03
## ASV3828     -4.631898e-03 -4.817473e-03 -5.009136e-03 -5.206991e-03
## ASV1930      2.412882e-03  2.513593e-03  2.617865e-03  2.725768e-03
## ASV2126      4.161168e-03  4.341099e-03  4.528060e-03  4.722270e-03
## ASV0793      5.213712e-03  5.452132e-03  5.701001e-03  5.960738e-03
## ASV0299     -1.070307e-04 -1.126720e-04 -1.186721e-04 -1.250611e-04
## ASV0208      3.737652e-03  3.905493e-03  4.080457e-03  4.262813e-03
## ASV0511     -1.464028e-03 -1.520949e-03 -1.579523e-03 -1.639752e-03
## ASV1123     -4.456595e-03 -4.633602e-03 -4.816197e-03 -5.004444e-03
## ASV0099      1.517986e-04  1.601196e-04  1.689391e-04  1.782902e-04
## ASV0752     -2.715269e-03 -2.843549e-03 -2.977788e-03 -3.118252e-03
## ASV0883      3.714921e-03  3.889277e-03  4.071627e-03  4.262317e-03
## ASV0683      4.829229e-03  5.052810e-03  5.286419e-03  5.530477e-03
## ASV4117     -7.600229e-03 -7.941658e-03 -8.297659e-03 -8.668800e-03
## ASV2172      4.484130e-04  4.631138e-04  4.779549e-04  4.929004e-04
## ASV0330     -1.427197e-03 -1.492099e-03 -1.559825e-03 -1.630487e-03
## ASV0728      6.969083e-03  7.275875e-03  7.595069e-03  7.927071e-03
## ASV0499      1.883773e-03  1.971565e-03  2.063354e-03  2.159312e-03
## ASV0120     -3.094996e-03 -3.231713e-03 -3.373993e-03 -3.522020e-03
## ASV1446      2.203171e-03  2.280159e-03  2.358585e-03  2.438358e-03
## ASV17171    -5.971323e-03 -6.234956e-03 -6.509482e-03 -6.795301e-03
## ASV0533      4.656015e-04  4.886321e-04  5.128185e-04  5.382186e-04
## ASV2495     -1.564060e-03 -1.645539e-03 -1.731502e-03 -1.822207e-03
## ASV5582      2.609343e-03  2.706195e-03  2.805439e-03  2.907032e-03
## ASV1488      1.032624e-03  1.075355e-03  1.119556e-03  1.165249e-03
## ASV0682      1.376867e-03  1.441525e-03  1.509161e-03  1.579905e-03
## ASV0068     -2.350467e-03 -2.455088e-03 -2.564036e-03 -2.677460e-03
## ASV1987     -5.998327e-03 -6.283078e-03 -6.581170e-03 -6.893202e-03
## ASV0035     -4.968989e-04 -5.267570e-04 -5.585694e-04 -5.924716e-04
## ASV7192     -3.584585e-03 -3.737726e-03 -3.896708e-03 -4.061699e-03
## ASV0873     -1.514157e-03 -1.709677e-03 -1.923490e-03 -2.156987e-03
## ASV4749     -3.122415e-04 -3.495530e-04 -3.904491e-04 -4.352277e-04
## ASV2174      2.400414e-03  2.491591e-03  2.585202e-03  2.681223e-03
## ASV1476     -2.645663e-03 -2.769975e-03 -2.900079e-03 -3.036242e-03
## ASV0740     -7.497560e-03 -7.847516e-03 -8.213455e-03 -8.596074e-03
## ASV0170     -1.443256e-03 -1.507736e-03 -1.574918e-03 -1.644903e-03
## ASV2466     -6.584058e-03 -6.878994e-03 -7.186427e-03 -7.506834e-03
## ASV1709      2.359829e-03  2.459547e-03  2.563117e-03  2.670672e-03
## ASV6170     -1.040930e-02 -1.088730e-02 -1.138648e-02 -1.190769e-02
## ASV3673      5.142835e-03  5.382701e-03  5.633499e-03  5.895703e-03
## ASV1745     -1.361335e-03 -1.428344e-03 -1.498701e-03 -1.572571e-03
##                                                                    
## (Intercept)  4.170387e-02  4.353915e-02  4.544834e-02  4.743384e-02
## ASV1236      8.004150e-03  8.334913e-03  8.677372e-03  9.031796e-03
## ASV0421      1.079617e-03  1.140404e-03  1.204754e-03  1.272872e-03
## ASV0691     -5.904277e-03 -6.117067e-03 -6.334755e-03 -6.557240e-03
## ASV0899      6.956108e-03  7.244507e-03  7.543013e-03  7.851826e-03
## ASV1004      1.606097e-02  1.672713e-02  1.741691e-02  1.813081e-02
## ASV1041     -6.569859e-03 -6.838026e-03 -7.115141e-03 -7.401330e-03
## ASV1058      1.001289e-02  1.042738e-02  1.085654e-02  1.130070e-02
## ASV12542     3.818285e-03  3.970252e-03  4.127096e-03  4.288889e-03
## ASV1294      9.329167e-03  9.716373e-03  1.011737e-02  1.053248e-02
## ASV13113     3.333128e-03  3.492795e-03  3.660103e-03  3.835411e-03
## ASV1318      9.294936e-03  9.679786e-03  1.007823e-02  1.049056e-02
## ASV2269     -1.604813e-02 -1.670736e-02 -1.738926e-02 -1.809426e-02
## ASV2542      8.174166e-03  8.545243e-03  8.932418e-03  9.336330e-03
## ASV2660     -6.360554e-03 -6.619533e-03 -6.887256e-03 -7.163877e-03
## ASV2737      2.137129e-03  2.218215e-03  2.301590e-03  2.387261e-03
## ASV2840      8.325438e-03  8.649117e-03  8.982322e-03  9.325086e-03
## ASV3053      4.305290e-02  4.477412e-02  4.655119e-02  4.838498e-02
## ASV3077      2.755480e-03  2.866688e-03  2.981620e-03  3.100348e-03
## ASV3134      5.259230e-03  5.505444e-03  5.762984e-03  6.032354e-03
## ASV3140      6.923821e-03  7.228173e-03  7.544813e-03  7.874147e-03
## ASV3579      2.611714e-03  2.741720e-03  2.878304e-03  3.021798e-03
## ASV6119     -4.390776e-03 -4.571085e-03 -4.757595e-03 -4.950421e-03
## ASV7557     -8.919800e-03 -9.285955e-03 -9.664688e-03 -1.005623e-02
## ASV8422      2.201019e-03  2.289495e-03  2.380903e-03  2.475298e-03
## ASV1086     -3.216918e-04 -3.326517e-04 -3.438283e-04 -3.552163e-04
## ASV1310      4.282431e-03  4.459100e-03  4.641937e-03  4.831071e-03
## ASV15750    -5.554846e-04 -5.756928e-04 -5.963525e-04 -6.174482e-04
## ASV16905    -1.834205e-03 -1.909499e-03 -1.987379e-03 -2.067895e-03
## ASV2033      8.266734e-03  8.646967e-03  9.043989e-03  9.458469e-03
## ASV2089      3.870780e-03  4.029952e-03  4.194615e-03  4.364871e-03
## ASV2127      1.259057e-02  1.311070e-02  1.364911e-02  1.420620e-02
## ASV2725      9.956958e-03  1.035738e-02  1.077093e-02  1.119782e-02
## ASV2804     -3.796471e-03 -3.952302e-03 -4.113487e-03 -4.280126e-03
## ASV3075      8.540640e-03  8.913104e-03  9.300611e-03  9.703695e-03
## ASV3327      1.202215e-02  1.256414e-02  1.312920e-02  1.371820e-02
## ASV3342      1.028170e-02  1.074089e-02  1.121932e-02  1.171770e-02
## ASV3532     -1.124659e-02 -1.174026e-02 -1.225397e-02 -1.278840e-02
## ASV3600      5.246172e-03  5.478099e-03  5.719563e-03  5.970900e-03
## ASV4013      9.615944e-03  1.002514e-02  1.044974e-02  1.089018e-02
## ASV4136      1.002346e-02  1.042969e-02  1.084963e-02  1.128354e-02
## ASV4195      3.874043e-02  4.032999e-02  4.197412e-02  4.367385e-02
## ASV4407     -1.496316e-02 -1.557688e-02 -1.621164e-02 -1.686785e-02
## ASV4717      2.491852e-03  2.584160e-03  2.678862e-03  2.775947e-03
## ASV6794      6.086648e-03  6.326800e-03  6.574553e-03  6.830017e-03
## ASV8324     -7.677964e-03 -7.992871e-03 -8.318577e-03 -8.655283e-03
## ASV8981     -1.102239e-04 -1.071821e-04 -1.033314e-04 -9.858701e-05
## ASV9859      2.979572e-03  3.131989e-03  3.292512e-03  3.461589e-03
## ASV0936      7.754594e-03  8.100582e-03  8.460933e-03  8.836149e-03
## ASV12683    -3.302049e-05 -3.646593e-05 -4.018171e-05 -4.418208e-05
## ASV1293      4.974617e-03  5.178281e-03  5.388934e-03  5.606709e-03
## ASV13055    -5.894310e-05 -5.583356e-05 -5.210455e-05 -4.769420e-05
## ASV17063    -3.979278e-03 -4.142284e-03 -4.310867e-03 -4.485129e-03
## ASV2228      3.244113e-03  3.376953e-03  3.514333e-03  3.656337e-03
## ASV2769      5.984903e-04  6.310091e-04  6.653415e-04  7.015845e-04
## ASV2803      3.421282e-03  3.553518e-03  3.689642e-03  3.829678e-03
## ASV2896      2.951036e-03  3.085653e-03  3.226223e-03  3.373000e-03
## ASV3062      3.689889e-03  3.868908e-03  4.056610e-03  4.253405e-03
## ASV3107      5.456778e-03  5.701351e-03  5.956289e-03  6.221987e-03
## ASV3265      7.101940e-03  7.391187e-03  7.690212e-03  7.999187e-03
## ASV3666      5.848179e-05  5.980535e-05  6.106054e-05  6.223330e-05
## ASV4497      2.466130e-03  2.569023e-03  2.675621e-03  2.786014e-03
## ASV6914     -4.225095e-04 -4.450217e-04 -4.687735e-04 -4.938318e-04
## ASV0576     -8.224974e-03 -8.537822e-03 -8.859418e-03 -9.189768e-03
## ASV0673      9.557036e-03  9.960884e-03  1.037969e-02  1.081383e-02
## ASV0772      4.467660e-03  4.659576e-03  4.858922e-03  5.065924e-03
## ASV0862      6.532448e-04  7.009972e-04  7.522342e-04  8.071884e-04
## ASV0898      3.614375e-03  3.782146e-03  3.957416e-03  4.140485e-03
## ASV0910      4.108072e-03  4.293663e-03  4.487220e-03  4.689051e-03
## ASV0964     -3.141151e-03 -3.263310e-03 -3.389094e-03 -3.518525e-03
## ASV10059     3.001782e-03  3.144295e-03  3.293493e-03  3.449680e-03
## ASV10263    -6.069367e-03 -6.318611e-03 -6.576440e-03 -6.843018e-03
## ASV1088      7.274664e-03  7.599543e-03  7.938169e-03  8.291074e-03
## ASV1101      8.655266e-03  9.008792e-03  9.374339e-03  9.752125e-03
## ASV1183      2.364409e-03  2.468003e-03  2.575774e-03  2.687862e-03
## ASV11956     2.139707e-03  2.220574e-03  2.303674e-03  2.389009e-03
## ASV12774     5.946692e-05  5.562023e-05  5.107737e-05  4.577280e-05
## ASV1321      1.067479e-02  1.116294e-02  1.167251e-02  1.220436e-02
## ASV13793    -4.184146e-03 -4.355924e-03 -4.533615e-03 -4.717329e-03
## ASV14482     2.445408e-04  2.528792e-04  2.614050e-04  2.701193e-04
## ASV15483     1.796546e-03  1.877172e-03  1.961193e-03  2.048735e-03
## ASV2062      8.143033e-03  8.488848e-03  8.847695e-03  9.219942e-03
## ASV2132      6.819928e-03  7.124679e-03  7.442184e-03  7.772902e-03
## ASV2413      6.225992e-03  6.484219e-03  6.751661e-03  7.028539e-03
## ASV2490      1.880462e-02  1.955185e-02  2.032288e-02  2.111801e-02
## ASV2594      2.468825e-03  2.578191e-03  2.692144e-03  2.810863e-03
## ASV2822     -1.104847e-02 -1.150256e-02 -1.197233e-02 -1.245808e-02
## ASV2863      1.166996e-02  1.214309e-02  1.263219e-02  1.313756e-02
## ASV2910      4.295225e-03  4.471379e-03  4.653618e-03  4.842067e-03
## ASV2980      4.879876e-03  5.087830e-03  5.303649e-03  5.527554e-03
## ASV3307      8.786123e-03  9.146941e-03  9.520190e-03  9.906113e-03
## ASV3474      6.161320e-03  6.447238e-03  6.746026e-03  7.058222e-03
## ASV3502      6.264474e-03  6.537321e-03  6.821029e-03  7.115955e-03
## ASV4236      8.791816e-03  9.136161e-03  9.490938e-03  9.856225e-03
## ASV4842     -1.015496e-03 -1.061077e-03 -1.108450e-03 -1.157655e-03
## ASV4894     -4.187048e-03 -4.359123e-03 -4.537139e-03 -4.721214e-03
## ASV5290      3.449886e-03  3.602991e-03  3.762399e-03  3.928328e-03
## ASV5501      2.092497e-03  2.184435e-03  2.280182e-03  2.379887e-03
## ASV5795      2.324593e-03  2.428376e-03  2.536492e-03  2.649097e-03
## ASV5987     -1.169826e-02 -1.217926e-02 -1.267691e-02 -1.319151e-02
## ASV6267     -1.317753e-02 -1.371915e-02 -1.427949e-02 -1.485891e-02
## ASV6862      5.214302e-03  5.422301e-03  5.637032e-03  5.858599e-03
## ASV7145      2.275119e-03  2.363949e-03  2.455580e-03  2.550064e-03
## ASV7673     -4.186682e-03 -4.358744e-03 -4.536750e-03 -4.720816e-03
## ASV7789      2.302456e-03  2.418384e-03  2.540296e-03  2.668502e-03
## ASV7809      2.259402e-04  2.429867e-04  2.613091e-04  2.809948e-04
## ASV8002     -5.287685e-03 -5.505032e-03 -5.729894e-03 -5.962420e-03
## ASV8205      2.290433e-03  2.391759e-03  2.497263e-03  2.607096e-03
## ASV9155     -1.320418e-03 -1.372456e-03 -1.426090e-03 -1.481330e-03
## ASV9221      6.947992e-04  7.375599e-04  7.831047e-04  8.316143e-04
## ASV9311     -8.481488e-03 -8.830106e-03 -9.190783e-03 -9.563757e-03
## ASV9557     -5.794676e-03 -6.032764e-03 -6.279080e-03 -6.533787e-03
## ASV9936     -1.168216e-02 -1.216196e-02 -1.265833e-02 -1.317159e-02
## ASV1445      7.345544e-03  7.670307e-03  8.008379e-03  8.360220e-03
## ASV4232      2.886814e-03  3.024744e-03  3.169303e-03  3.320812e-03
## ASV6479      1.170538e-03  1.238673e-03  1.311000e-03  1.387782e-03
## ASV0142     -5.010483e-03 -5.214104e-03 -5.424608e-03 -5.642121e-03
## ASV0378      2.455508e-03  2.572040e-03  2.694018e-03  2.821680e-03
## ASV1122      7.149235e-03  7.468969e-03  7.802126e-03  8.149198e-03
## ASV0123     -4.417677e-03 -4.596552e-03 -4.781413e-03 -4.972366e-03
## ASV2064      2.179698e-03  2.260134e-03  2.342511e-03  2.426784e-03
## ASV4459     -2.841802e-04 -2.928710e-04 -3.016400e-04 -3.104751e-04
## ASV0448      1.965427e-03  2.058852e-03  2.156654e-03  2.259027e-03
## ASV0397      4.129113e-03  4.307026e-03  4.491835e-03  4.683747e-03
## ASV0485      4.750031e-03  4.950393e-03  5.158186e-03  5.373611e-03
## ASV1566      7.053254e-03  7.355633e-03  7.669597e-03  7.995483e-03
## ASV1365      6.078849e-03  6.344293e-03  6.620269e-03  6.907105e-03
## ASV1065      8.627100e-03  9.003218e-03  9.394306e-03  9.800845e-03
## ASV0722     -4.659394e-04 -4.878483e-04 -5.107954e-04 -5.348321e-04
## ASV12660    -4.774181e-03 -4.966491e-03 -5.165188e-03 -5.370383e-03
## ASV0223      1.317402e-03  1.373529e-03  1.431798e-03  1.492275e-03
## ASV0229      2.063598e-03  2.156411e-03  2.253181e-03  2.354060e-03
## ASV0877      7.836807e-04  8.108879e-04  8.384856e-04  8.664155e-04
## ASV0983      4.691438e-03  4.886940e-03  5.089450e-03  5.299131e-03
## ASV0626      6.532236e-04  6.940053e-04  7.374036e-04  7.835763e-04
## ASV4146      2.233614e-04  2.314223e-04  2.395573e-04  2.477333e-04
## ASV4175     -5.961151e-03 -6.226384e-03 -6.502621e-03 -6.790252e-03
## ASV2082     -2.964642e-03 -3.123049e-03 -3.290372e-03 -3.467127e-03
## ASV2272      2.829284e-03  2.954602e-03  3.085121e-03  3.221033e-03
## ASV2245     -4.275848e-03 -4.467730e-03 -4.667698e-03 -4.876049e-03
## ASV0590     -2.871553e-03 -3.030921e-03 -3.199604e-03 -3.378153e-03
## ASV0217      4.180845e-04  4.544777e-04  4.938299e-04  5.363547e-04
## ASV0416      2.961277e-03  3.068250e-03  3.177617e-03  3.289305e-03
## ASV1056      4.183807e-03  4.375985e-03  4.576618e-03  4.786040e-03
## ASV7777     -5.778487e-03 -6.033825e-03 -6.299680e-03 -6.576432e-03
## ASV0455      1.029210e-03  1.073852e-03  1.120240e-03  1.168426e-03
## ASV0604      2.781925e-03  2.912176e-03  3.048355e-03  3.190709e-03
## ASV6100     -4.023867e-03 -4.205617e-03 -4.395197e-03 -4.592915e-03
## ASV11359    -8.554899e-03 -8.931808e-03 -9.324013e-03 -9.732025e-03
## ASV6604      1.218782e-03  1.275461e-03  1.334693e-03  1.396584e-03
## ASV5004     -3.025743e-03 -3.157701e-03 -3.294944e-03 -3.437651e-03
## ASV1483     -1.295201e-03 -1.350859e-03 -1.408661e-03 -1.468672e-03
## ASV9773     -3.873430e-03 -4.046163e-03 -4.226132e-03 -4.413605e-03
## ASV4059      1.600429e-04  1.809983e-04  2.039733e-04  2.291288e-04
## ASV1193      4.611835e-03  4.811076e-03  5.018096e-03  5.233133e-03
## ASV4610     -5.252240e-04 -5.301247e-04 -5.338268e-04 -5.361950e-04
## ASV0742     -2.663534e-04 -2.623530e-04 -2.569231e-04 -2.499224e-04
## ASV1502     -3.182013e-04 -3.420447e-04 -3.676681e-04 -3.951939e-04
## ASV0195      4.598518e-05  4.208853e-05  3.756129e-05  3.234742e-05
## ASV1213      3.082301e-03  3.200275e-03  3.321590e-03  3.446249e-03
## ASV1648     -3.609156e-03 -3.771839e-03 -3.941521e-03 -4.118481e-03
## ASV6984     -3.380468e-03 -3.533240e-03 -3.692629e-03 -3.858903e-03
## ASV0396     -1.157075e-04 -1.144207e-04 -1.126058e-04 -1.102160e-04
## ASV4297      4.538879e-03  4.718954e-03  4.904701e-03  5.096184e-03
## ASV2622      7.166543e-03  7.462976e-03  7.769886e-03  8.087508e-03
## ASV3512      3.087484e-03  3.243486e-03  3.407620e-03  3.580319e-03
## ASV2411      5.153329e-03  5.391770e-03  5.640897e-03  5.901152e-03
## ASV2291     -2.515458e-03 -2.657486e-03 -2.807930e-03 -2.967287e-03
## ASV0807      6.794140e-03  7.087580e-03  7.392418e-03  7.708992e-03
## ASV1292      1.523818e-03  1.579178e-03  1.635837e-03  1.693766e-03
## ASV1035      6.061759e-03  6.309056e-03  6.564880e-03  6.829416e-03
## ASV0070      1.284681e-04  1.409320e-04  1.544910e-04  1.692312e-04
## ASV0255      5.483425e-04  5.680145e-04  5.880734e-04  6.084940e-04
## ASV0057     -1.625889e-03 -1.688080e-03 -1.752008e-03 -1.817669e-03
## ASV0077     -3.170870e-04 -3.265626e-04 -3.360514e-04 -3.455257e-04
## ASV0625      3.462288e-03  3.600575e-03  3.743310e-03  3.890553e-03
## ASV2464      2.349495e-02  2.443029e-02  2.539588e-02  2.639220e-02
## ASV1315      6.742706e-03  7.057171e-03  7.385923e-03  7.729568e-03
## ASV2673      5.791549e-03  6.062377e-03  6.345574e-03  6.641671e-03
## ASV2161      2.443602e-03  2.557525e-03  2.676651e-03  2.801207e-03
## ASV0337     -1.370393e-03 -1.431652e-03 -1.495478e-03 -1.561964e-03
## ASV7680     -8.970758e-03 -9.374406e-03 -9.795221e-03 -1.023385e-02
## ASV0611      5.018784e-03  5.245526e-03  5.482015e-03  5.728632e-03
## ASV3118     -5.330654e-03 -5.581782e-03 -5.844505e-03 -6.119329e-03
## ASV1284      1.331540e-03  1.344720e-03  1.354550e-03  1.360596e-03
## ASV0889      3.661867e-03  3.815640e-03  3.975090e-03  4.140371e-03
## ASV4649     -1.875223e-03 -1.957559e-03 -2.043233e-03 -2.132362e-03
## ASV1108     -4.038894e-03 -4.233801e-03 -4.438120e-03 -4.652297e-03
## ASV0738      2.343992e-03  2.466744e-03  2.596184e-03  2.732685e-03
## ASV0473     -5.167557e-04 -5.466731e-04 -5.783467e-04 -6.118711e-04
## ASV0598     -1.240093e-03 -1.308647e-03 -1.381225e-03 -1.458069e-03
## ASV0429      2.674768e-03  2.782778e-03  2.894323e-03  3.009451e-03
## ASV1549      5.351129e-03  5.602013e-03  5.864408e-03  6.138815e-03
## ASV1203      3.993377e-03  4.161674e-03  4.336168e-03  4.517015e-03
## ASV4532      1.403007e-04  1.436417e-04  1.469246e-04  1.501379e-04
## ASV0274      7.602126e-04  7.978397e-04  8.373092e-04  8.787031e-04
## ASV0163     -2.999644e-03 -3.118917e-03 -3.242023e-03 -3.369021e-03
## ASV1298      2.997227e-04  3.094601e-04  3.193873e-04  3.295065e-04
## ASV9424     -6.989169e-03 -7.307062e-03 -7.638824e-03 -7.985016e-03
## ASV0412      6.891244e-03  7.178729e-03  7.476594e-03  7.785092e-03
## ASV0284      1.324180e-03  1.368979e-03  1.414464e-03  1.460567e-03
## ASV0620     -1.602935e-03 -1.686667e-03 -1.774915e-03 -1.867921e-03
## ASV0153     -7.150176e-03 -7.484853e-03 -7.834806e-03 -8.200687e-03
## ASV0498      2.468432e-03  2.579060e-03  2.694285e-03  2.814263e-03
## ASV0097      1.404811e-03  1.470650e-03  1.539512e-03  1.611529e-03
## ASV0104     -9.479797e-03 -9.885540e-03 -1.030673e-02 -1.074380e-02
## ASV1282      3.168054e-03  3.294475e-03  3.424856e-03  3.559226e-03
## ASV3883     -2.812914e-03 -2.951800e-03 -3.097563e-03 -3.250529e-03
## ASV0801      1.316042e-03  1.375146e-03  1.436752e-03  1.500955e-03
## ASV1611     -6.317319e-03 -6.608827e-03 -6.913355e-03 -7.231445e-03
## ASV0227     -1.268907e-03 -1.338118e-03 -1.411253e-03 -1.488532e-03
## ASV0833      2.109561e-03  2.203454e-03  2.301228e-03  2.403020e-03
## ASV0718      9.407738e-03  9.824694e-03  1.025887e-02  1.071087e-02
## ASV1139      1.005410e-03  1.031921e-03  1.057984e-03  1.083457e-03
## ASV0766     -1.402042e-03 -1.471455e-03 -1.544308e-03 -1.620765e-03
## ASV2091      7.276521e-03  7.567434e-03  7.867692e-03  8.177415e-03
## ASV1238     -7.105527e-03 -7.430709e-03 -7.770337e-03 -8.125025e-03
## ASV9193     -8.496279e-04 -9.029715e-04 -9.599006e-04 -1.020661e-03
## ASV0290      8.744988e-04  9.030956e-04  9.320892e-04  9.614423e-04
## ASV0231      2.710678e-03  2.823442e-03  2.940223e-03  3.061113e-03
## ASV0185      1.791790e-03  1.885115e-03  1.983491e-03  2.087197e-03
## ASV2330      3.007108e-03  3.123610e-03  3.243538e-03  3.366910e-03
## ASV3119     -1.611925e-03 -1.694964e-03 -1.782417e-03 -1.874520e-03
## ASV2368     -3.714216e-03 -3.889924e-03 -4.073911e-03 -4.266566e-03
## ASV0122     -1.700277e-03 -1.772435e-03 -1.847303e-03 -1.924957e-03
## ASV1044      4.553677e-03  4.764011e-03  4.983763e-03  5.213328e-03
## ASV0160     -1.754861e-03 -1.823303e-03 -1.893812e-03 -1.966406e-03
## ASV0326      4.950492e-04  5.170377e-04  5.399171e-04  5.637146e-04
## ASV1388      8.847194e-03  9.224536e-03  9.616142e-03  1.002241e-02
## ASV0792      6.432389e-03  6.695408e-03  6.967413e-03  7.248573e-03
## ASV0036     -2.145567e-03 -2.245957e-03 -2.350909e-03 -2.460614e-03
## ASV2125      6.360943e-03  6.635423e-03  6.920554e-03  7.216651e-03
## ASV1075     -9.718943e-05 -1.016504e-04 -1.063321e-04 -1.112488e-04
## ASV0390      3.546692e-03  3.713480e-03  3.888014e-03  4.070647e-03
## ASV3790     -4.917209e-03 -5.138136e-03 -5.368441e-03 -5.608476e-03
## ASV1535     -1.525252e-03 -1.602932e-03 -1.684670e-03 -1.770675e-03
## ASV0263      5.950595e-03  6.211723e-03  6.483398e-03  6.765975e-03
## ASV0675      9.121494e-03  9.537431e-03  9.971524e-03  1.042450e-02
## ASV3348      7.723457e-04  8.103052e-04  8.501354e-04  8.919252e-04
## ASV0058     -2.609509e-03 -2.720177e-03 -2.834972e-03 -2.954002e-03
## ASV4142      3.584819e-03  3.730075e-03  3.880147e-03  4.035109e-03
## ASV0059     -2.089121e-03 -2.176577e-03 -2.267194e-03 -2.361045e-03
## ASV0013     -3.791840e-03 -3.957563e-03 -4.129912e-03 -4.309105e-03
## ASV0033     -1.859596e-03 -1.946179e-03 -2.036668e-03 -2.131225e-03
## ASV4354     -2.241195e-03 -2.340202e-03 -2.443323e-03 -2.550714e-03
## ASV0022     -1.569230e-03 -1.642230e-03 -1.718523e-03 -1.798249e-03
## ASV0134     -1.536599e-03 -1.611874e-03 -1.690871e-03 -1.773770e-03
## ASV0415      2.726901e-04  2.879015e-04  3.039618e-04  3.209131e-04
## ASV10103    -8.622203e-03 -9.015663e-03 -9.426321e-03 -9.854864e-03
## ASV1613      6.101206e-03  6.350650e-03  6.608559e-03  6.875080e-03
## ASV0135     -7.600575e-04 -7.889755e-04 -8.186836e-04 -8.491778e-04
## ASV0469     -7.978161e-03 -8.314507e-03 -8.663353e-03 -9.025044e-03
## ASV0471      4.933425e-03  5.148047e-03  5.371178e-03  5.603092e-03
## ASV0451     -9.480139e-04 -1.001633e-03 -1.058430e-03 -1.118592e-03
## ASV0747      2.838612e-03  2.964731e-03  3.096052e-03  3.232754e-03
## ASV1314     -2.944875e-03 -3.084362e-03 -3.230410e-03 -3.383320e-03
## ASV0425     -9.698609e-03 -1.009116e-02 -1.049680e-02 -1.091575e-02
## ASV0559     -2.476454e-03 -2.584281e-03 -2.696493e-03 -2.813253e-03
## ASV0148     -4.672280e-04 -4.790314e-04 -4.905497e-04 -5.017086e-04
## ASV0129      7.635169e-04  8.132672e-04  8.664544e-04  9.233160e-04
## ASV1072      6.039325e-04  6.245808e-04  6.455399e-04  6.667741e-04
## ASV2390      4.881272e-03  5.070297e-03  5.264756e-03  5.464646e-03
## ASV0548      3.385200e-03  3.531542e-03  3.683589e-03  3.841512e-03
## ASV0168     -1.711797e-03 -1.783563e-03 -1.857950e-03 -1.935024e-03
## ASV0066     -1.940577e-03 -2.022855e-03 -2.108187e-03 -2.196652e-03
## ASV0468     -1.047648e-03 -1.093979e-03 -1.142223e-03 -1.192449e-03
## ASV0172     -5.310681e-04 -5.490256e-04 -5.672435e-04 -5.856918e-04
## ASV0236      1.201280e-04  1.458432e-04  1.743400e-04  2.058534e-04
## ASV0250      2.983437e-03  3.132616e-03  3.289432e-03  3.454283e-03
## ASV0338      1.361561e-03  1.424665e-03  1.490534e-03  1.559269e-03
## ASV0450     -2.977136e-04 -3.152959e-04 -3.339779e-04 -3.538292e-04
## ASV0377      2.418977e-03  2.521153e-03  2.627103e-03  2.736922e-03
## ASV1022     -9.307596e-05 -9.594212e-05 -9.878695e-05 -1.015939e-04
## ASV6174     -8.028375e-05 -8.631615e-05 -9.283330e-05 -9.987380e-05
## ASV0786     -4.366404e-04 -4.637990e-04 -4.926912e-04 -5.234214e-04
## ASV0053     -2.670742e-03 -2.788398e-03 -2.910833e-03 -3.038206e-03
## ASV0697     -1.569602e-03 -1.634104e-03 -1.700864e-03 -1.769932e-03
## ASV0785      3.353218e-03  3.495111e-03  3.642278e-03  3.794859e-03
## ASV1967     -3.312354e-03 -3.451211e-03 -3.595185e-03 -3.744415e-03
## ASV0385      1.190156e-03  1.246506e-03  1.305444e-03  1.367076e-03
## ASV0295      2.738748e-04  2.923288e-04  3.120912e-04  3.332535e-04
## ASV0072     -2.573093e-03 -2.678921e-03 -2.788389e-03 -2.901562e-03
## ASV0157     -2.287186e-04 -2.288895e-04 -2.281916e-04 -2.265194e-04
## ASV0501      5.783673e-03  6.039892e-03  6.306618e-03  6.584208e-03
## ASV10729    -7.314938e-03 -7.643334e-03 -7.985628e-03 -8.342336e-03
## ASV1470      3.468726e-03  3.601719e-03  3.738449e-03  3.878908e-03
## ASV0050     -6.147675e-03 -6.408973e-03 -6.680064e-03 -6.961210e-03
## ASV0411     -1.449015e-03 -1.516195e-03 -1.586401e-03 -1.659761e-03
## ASV0549      2.306194e-03  2.411068e-03  2.520484e-03  2.634618e-03
## ASV0184      7.481270e-04  7.803320e-04  8.138115e-04  8.486098e-04
## ASV0705      1.452273e-03  1.511919e-03  1.573601e-03  1.637354e-03
## ASV1715      3.169712e-03  3.308992e-03  3.453901e-03  3.604626e-03
## ASV0603      5.096129e-04  5.336169e-04  5.587707e-04  5.851334e-04
## ASV0826      5.294801e-03  5.522578e-03  5.759170e-03  6.004842e-03
## ASV0034     -1.666757e-03 -1.735782e-03 -1.807233e-03 -1.881161e-03
## ASV0838      9.228750e-04  9.398063e-04  9.552804e-04  9.690549e-04
## ASV0614     -1.447800e-03 -1.509946e-03 -1.574490e-03 -1.641501e-03
## ASV0014     -3.853052e-03 -4.019697e-03 -4.192849e-03 -4.372706e-03
## ASV0585      2.389045e-04  2.324986e-04  2.244055e-04  2.144540e-04
## ASV0016     -4.024946e-03 -4.199018e-03 -4.379887e-03 -4.567759e-03
## ASV5394     -3.055431e-03 -3.190952e-03 -3.332055e-03 -3.478936e-03
## ASV0666      6.404487e-03  6.665769e-03  6.935942e-03  7.215171e-03
## ASV2085      1.206167e-03  1.230857e-03  1.254182e-03  1.275909e-03
## ASV0003     -2.742265e-03 -2.860665e-03 -2.983672e-03 -3.111426e-03
## ASV0346      1.441242e-03  1.508913e-03  1.579656e-03  1.653598e-03
## ASV0267      5.128460e-05  5.912142e-05  6.774224e-05  7.720870e-05
## ASV0353      2.263357e-03  2.367559e-03  2.476384e-03  2.590024e-03
## ASV2419      5.860103e-03  6.109371e-03  6.368036e-03  6.636358e-03
## ASV0447      3.326738e-03  3.480471e-03  3.641047e-03  3.808743e-03
## ASV0654      4.773222e-03  4.980235e-03  5.195364e-03  5.418854e-03
## ASV0151      7.131612e-04  7.510800e-04  7.911117e-04  8.333766e-04
## ASV0065     -1.830461e-03 -1.908386e-03 -1.989248e-03 -2.073128e-03
## ASV0527      4.524075e-03  4.718826e-03  4.921115e-03  5.131169e-03
## ASV4055     -7.752115e-04 -8.143141e-04 -8.554903e-04 -8.988593e-04
## ASV0166     -2.216416e-03 -2.306752e-03 -2.400148e-03 -2.496657e-03
## ASV0417     -8.702552e-04 -9.023446e-04 -9.352136e-04 -9.688467e-04
## ASV0078     -1.321437e-03 -1.375924e-03 -1.432291e-03 -1.490573e-03
## ASV0322     -1.826033e-04 -1.841435e-04 -1.850948e-04 -1.853710e-04
## ASV0156     -3.272051e-03 -3.419241e-03 -3.572713e-03 -3.732707e-03
## ASV0648     -7.134933e-03 -7.458230e-03 -7.795462e-03 -8.147169e-03
## ASV0407     -5.487655e-04 -5.749173e-04 -6.023153e-04 -6.310187e-04
## ASV2030     -1.151763e-03 -1.201490e-03 -1.253295e-03 -1.307273e-03
## ASV0300      8.701383e-04  9.111545e-04  9.540607e-04  9.989380e-04
## ASV1150      2.123083e-04  2.237196e-04  2.357598e-04  2.484625e-04
## ASV0958      2.698078e-03  2.826421e-03  2.960835e-03  3.101603e-03
## ASV0216     -2.814501e-03 -2.933834e-03 -3.057718e-03 -3.186297e-03
## ASV0446      4.395862e-03  4.594742e-03  4.802130e-03  5.018348e-03
## ASV0367     -2.850345e-03 -2.976801e-03 -3.108485e-03 -3.245582e-03
## ASV0200     -1.692557e-03 -1.767327e-03 -1.845151e-03 -1.926132e-03
## ASV0334     -8.063525e-04 -8.323395e-04 -8.586385e-04 -8.852092e-04
## ASV1311      1.014038e-03  1.050084e-03  1.086856e-03  1.124315e-03
## ASV0458      1.482861e-03  1.534387e-03  1.586888e-03  1.640310e-03
## ASV1371      2.865023e-04  3.008043e-04  3.158079e-04  3.315432e-04
## ASV0418      3.614862e-03  3.760906e-03  3.911814e-03  4.067670e-03
## ASV0004      5.210096e-04  5.417695e-04  5.631934e-04  5.852898e-04
## ASV1943      9.359499e-03  9.679356e-03  1.000529e-02  1.033704e-02
## ASV1495     -9.296401e-04 -9.864063e-04 -1.046858e-03 -1.111239e-03
## ASV0901     -3.259130e-03 -3.409067e-03 -3.565695e-03 -3.729299e-03
## ASV0628      1.586097e-03  1.646094e-03  1.707680e-03  1.770840e-03
## ASV0400      9.963513e-04  1.036962e-03  1.078921e-03  1.122247e-03
## ASV0116     -9.560329e-04 -9.997814e-04 -1.045458e-03 -1.093143e-03
## ASV0788      8.471575e-03  8.861099e-03  9.267951e-03  9.692855e-03
## ASV0117      6.415523e-04  6.725232e-04  7.049840e-04  7.390038e-04
## ASV3137     -1.879649e-04 -1.956898e-04 -2.036803e-04 -2.119408e-04
## ASV0001      5.562024e-04  5.780521e-04  6.005691e-04  6.237587e-04
## ASV1651      1.600275e-03  1.664618e-03  1.731072e-03  1.799669e-03
## ASV1692      7.040771e-03  7.363036e-03  7.699480e-03  8.050679e-03
## ASV0660      2.278172e-03  2.361639e-03  2.447022e-03  2.534257e-03
## ASV0508      1.116564e-04  1.155429e-04  1.195055e-04  1.235406e-04
## ASV1660     -1.493603e-03 -1.568204e-03 -1.646546e-03 -1.728808e-03
## ASV0233      2.135254e-03  2.229529e-03  2.327663e-03  2.429791e-03
## ASV1343     -3.998485e-03 -4.180583e-03 -4.370631e-03 -4.568948e-03
## ASV0209      1.864014e-03  1.937587e-03  2.013438e-03  2.091587e-03
## ASV0193     -2.190838e-03 -2.278562e-03 -2.369097e-03 -2.462473e-03
## ASV0357      9.767194e-04  1.028781e-03  1.083785e-03  1.141906e-03
## ASV0198      1.703116e-03  1.775107e-03  1.849787e-03  1.927231e-03
## ASV0007      4.837577e-04  5.020875e-04  5.209144e-04  5.402359e-04
## ASV1772     -6.965815e-04 -7.202087e-04 -7.440968e-04 -7.681830e-04
## ASV0009      3.931812e-04  4.074690e-04  4.220860e-04  4.370237e-04
## ASV0006     -4.888521e-04 -5.122599e-04 -5.367804e-04 -5.624644e-04
## ASV0011     -1.641386e-03 -1.715409e-03 -1.792593e-03 -1.873058e-03
## ASV0015      2.967676e-04  3.074990e-04  3.184698e-04  3.296725e-04
## ASV0017      3.350388e-04  3.472441e-04  3.597348e-04  3.725046e-04
## ASV0235     -1.524690e-03 -1.594106e-03 -1.666533e-03 -1.742088e-03
## ASV0382      1.190052e-03  1.243604e-03  1.299365e-03  1.357402e-03
## ASV2357      4.939762e-03  5.162256e-03  5.394256e-03  5.636131e-03
## ASV0567     -9.670926e-04 -1.011752e-03 -1.058448e-03 -1.107274e-03
## ASV0165      8.232870e-04  8.602177e-04  8.986999e-04  9.387894e-04
## ASV0005      1.171200e-03  1.221701e-03  1.274154e-03  1.328616e-03
## ASV0384     -7.262910e-05 -7.076857e-05 -6.838442e-05 -6.541988e-05
## ASV0002      2.132785e-04  2.219993e-04  2.310247e-04  2.403618e-04
## ASV3017      6.007023e-03  6.248783e-03  6.498440e-03  6.756110e-03
## ASV0091     -1.555810e-04 -1.622372e-04 -1.691638e-04 -1.763723e-04
## ASV0186     -2.373061e-03 -2.476453e-03 -2.583926e-03 -2.695607e-03
## ASV0370      1.237053e-03  1.289054e-03  1.342952e-03  1.398795e-03
## ASV0018      1.504925e-03  1.570232e-03  1.638101e-03  1.708611e-03
## ASV1377      1.468787e-02  1.529023e-02  1.591332e-02  1.655756e-02
## ASV0019      1.580258e-03  1.648970e-03  1.720392e-03  1.794608e-03
## ASV0023     -1.013280e-03 -1.059610e-03 -1.107965e-03 -1.158422e-03
## ASV2194      1.648241e-03  1.725523e-03  1.806382e-03  1.890978e-03
## ASV1155      6.143510e-03  6.396751e-03  6.659055e-03  6.930656e-03
## ASV0510     -1.570095e-03 -1.627509e-03 -1.686292e-03 -1.746420e-03
## ASV2371     -3.698843e-03 -3.850959e-03 -4.008441e-03 -4.171413e-03
## ASV0024     -1.258158e-03 -1.315379e-03 -1.375075e-03 -1.437342e-03
## ASV2452      3.601464e-03  3.738383e-03  3.879013e-03  4.023329e-03
## ASV2332     -1.071194e-02 -1.116067e-02 -1.162597e-02 -1.210830e-02
## ASV2591      3.137474e-03  3.296966e-03  3.464468e-03  3.640344e-03
## ASV0521      2.554054e-03  2.670129e-03  2.791239e-03  2.917584e-03
## ASV5542      2.442170e-03  2.552411e-03  2.667296e-03  2.786991e-03
## ASV0336     -3.686800e-04 -3.906085e-04 -4.138933e-04 -4.386160e-04
## ASV10102     4.509418e-03  4.713282e-03  4.925834e-03  5.147395e-03
## ASV16823    -6.496474e-03 -6.751476e-03 -7.014479e-03 -7.285594e-03
## ASV3104      3.360256e-02  3.492109e-02  3.628096e-02  3.768272e-02
## ASV0781      4.919130e-03  5.132218e-03  5.353682e-03  5.583786e-03
## ASV10899     3.202454e-03  3.369042e-03  3.544535e-03  3.729406e-03
## ASV11222    -1.142902e-02 -1.187745e-02 -1.233994e-02 -1.281669e-02
## ASV11327    -1.025770e-02 -1.066003e-02 -1.107497e-02 -1.150269e-02
## ASV12458    -1.142114e-02 -1.186895e-02 -1.233078e-02 -1.280682e-02
## ASV1636      6.633065e-03  6.908280e-03  7.193270e-03  7.488259e-03
## ASV1890     -5.083325e-03 -5.267828e-03 -5.456897e-03 -5.650496e-03
## ASV2898      8.903991e-03  9.274502e-03  9.658279e-03  1.005563e-02
## ASV8328      1.561543e-03  1.672752e-03  1.791973e-03  1.919751e-03
## ASV0709     -1.004559e-02 -1.047372e-02 -1.091795e-02 -1.137872e-02
## ASV0856      8.721072e-03  9.127301e-03  9.551855e-03  9.995494e-03
## ASV0909      2.820334e-03  2.978307e-03  3.145541e-03  3.322576e-03
## ASV0937     -6.079205e-03 -6.355477e-03 -6.643882e-03 -6.944925e-03
## ASV11390    -1.629643e-02 -1.693531e-02 -1.759418e-02 -1.827332e-02
## ASV11966     4.349961e-03  4.559068e-03  4.778054e-03  5.007353e-03
## ASV12990     2.901582e-03  3.019607e-03  3.141570e-03  3.267535e-03
## ASV14797     4.262822e-03  4.433564e-03  4.609854e-03  4.791779e-03
## ASV14904    -2.338351e-02 -2.430021e-02 -2.524560e-02 -2.622009e-02
## ASV15304     2.813003e-03  2.955467e-03  3.105169e-03  3.262458e-03
## ASV16696    -8.077585e-03 -8.394194e-03 -8.720711e-03 -9.057273e-03
## ASV1690      1.483802e-02  1.552871e-02  1.625015e-02  1.700354e-02
## ASV2029      9.848778e-03  1.026706e-02  1.070112e-02  1.115140e-02
## ASV2834      1.264532e-02  1.320952e-02  1.379722e-02  1.440924e-02
## ASV4003      1.085440e-02  1.138167e-02  1.193473e-02  1.251485e-02
## ASV4064      6.037404e-03  6.309858e-03  6.593877e-03  6.889888e-03
## ASV4294      3.898399e-03  4.097128e-03  4.306212e-03  4.526187e-03
## ASV4609      3.316232e-03  3.455536e-03  3.599958e-03  3.749635e-03
## ASV6283     -7.552913e-03 -7.849113e-03 -8.154601e-03 -8.469507e-03
## ASV6491     -1.082194e-02 -1.124620e-02 -1.168374e-02 -1.213477e-02
## ASV7453      5.796416e-03  6.077422e-03  6.371882e-03  6.680398e-03
## ASV7959      2.257749e-03  2.382276e-03  2.513903e-03  2.653028e-03
## ASV8219      9.351345e-02  9.717945e-02  1.009603e-01  1.048578e-01
## ASV8547     -9.684417e-03 -1.006394e-02 -1.045535e-02 -1.085882e-02
## ASV9319      4.561305e-03  4.772773e-03  4.993736e-03  5.224591e-03
## ASV9382     -1.894555e-02 -1.968793e-02 -2.045355e-02 -2.124275e-02
## ASV11516    -1.264975e-02 -1.314526e-02 -1.365627e-02 -1.418300e-02
## ASV14377    -9.130662e-03 -9.488197e-03 -9.856911e-03 -1.023696e-02
## ASV1867      7.555766e-03  7.897372e-03  8.253608e-03  8.625030e-03
## ASV1895      3.519597e-03  3.652601e-03  3.789041e-03  3.928865e-03
## ASV3168      4.516623e-03  4.696275e-03  4.881536e-03  5.072455e-03
## ASV4449      2.577581e-02  2.689448e-02  2.805779e-02  2.926727e-02
## ASV6596      5.743617e-03  6.028148e-03  6.326977e-03  6.640819e-03
## ASV7492     -6.305623e-04 -6.264238e-04 -6.195994e-04 -6.098143e-04
## ASV9854     -1.929792e-03 -2.003571e-03 -2.079559e-03 -2.157785e-03
## ASV6296      1.531578e-01  1.591532e-01  1.653360e-01  1.717086e-01
## ASV4201      1.145797e-03  1.229879e-03  1.320152e-03  1.417044e-03
## ASV0552      5.208893e-03  5.442541e-03  5.686026e-03  5.939708e-03
## ASV3671     -3.386192e-03 -3.531574e-03 -3.682786e-03 -3.840048e-03
## ASV3529     -6.157282e-04 -6.182818e-04 -6.191269e-04 -6.180907e-04
## ASV1060      1.422778e-03  1.490323e-03  1.561078e-03  1.635196e-03
## ASV0239     -1.739900e-03 -1.805831e-03 -1.873582e-03 -1.943149e-03
## ASV5711     -8.209452e-03 -8.553700e-03 -8.910715e-03 -9.280859e-03
## ASV4152     -1.188414e-02 -1.240731e-02 -1.295184e-02 -1.351849e-02
## ASV1461      5.648666e-03  5.865673e-03  6.088882e-03  6.318304e-03
## ASV2877      2.961152e-03  3.077369e-03  3.197100e-03  3.320366e-03
## ASV0012      5.351725e-04  5.585588e-04  5.828855e-04  6.081846e-04
## ASV9823      6.377084e-04  6.537097e-04  6.692720e-04  6.842835e-04
## ASV0008      5.678195e-04  5.923609e-04  6.178688e-04  6.443745e-04
## ASV7832     -7.034339e-03 -7.348227e-03 -7.675402e-03 -8.016375e-03
## ASV1915     -8.579201e-04 -8.935503e-04 -9.305639e-04 -9.690165e-04
## ASV0055     -6.692169e-04 -7.034121e-04 -7.394015e-04 -7.772791e-04
## ASV0032      2.519706e-04  2.599578e-04  2.680183e-04  2.761359e-04
## ASV2977     -9.828016e-03 -1.025761e-02 -1.070446e-02 -1.116917e-02
## ASV0466      7.482403e-03  7.770782e-03  8.067493e-03  8.372558e-03
## ASV3866      5.523313e-03  5.776215e-03  6.040264e-03  6.315916e-03
## ASV0040      1.966858e-03  2.054288e-03  2.145349e-03  2.240171e-03
## ASV0496     -6.367500e-04 -6.806484e-04 -7.276596e-04 -7.779941e-04
## ASV0052      1.653086e-03  1.726711e-03  1.803401e-03  1.883268e-03
## ASV3828     -5.411132e-03 -5.621650e-03 -5.838632e-03 -6.062154e-03
## ASV1930      2.837368e-03  2.952729e-03  3.071908e-03  3.194957e-03
## ASV2126      4.923948e-03  5.133316e-03  5.350599e-03  5.576023e-03
## ASV0793      6.231773e-03  6.514551e-03  6.809527e-03  7.117175e-03
## ASV0299     -1.318721e-04 -1.391418e-04 -1.469107e-04 -1.552232e-04
## ASV0208      4.452839e-03  4.650821e-03  4.857053e-03  5.071839e-03
## ASV0511     -1.701632e-03 -1.765158e-03 -1.830316e-03 -1.897093e-03
## ASV1123     -5.198399e-03 -5.398109e-03 -5.603611e-03 -5.814935e-03
## ASV0099      1.882081e-04  1.987303e-04  2.098973e-04  2.217521e-04
## ASV0752     -3.265215e-03 -3.418962e-03 -3.579788e-03 -3.748002e-03
## ASV0883      4.461703e-03  4.670152e-03  4.888046e-03  5.115779e-03
## ASV0683      5.785417e-03  6.051689e-03  6.329755e-03  6.620096e-03
## ASV4117     -9.055664e-03 -9.458858e-03 -9.879004e-03 -1.031675e-02
## ASV2172      5.079099e-04  5.229384e-04  5.379360e-04  5.528472e-04
## ASV0330     -1.704201e-03 -1.781088e-03 -1.861272e-03 -1.944881e-03
## ASV0728      8.272298e-03  8.631171e-03  9.004116e-03  9.391565e-03
## ASV0499      2.259620e-03  2.364463e-03  2.474035e-03  2.588535e-03
## ASV0120     -3.675983e-03 -3.836072e-03 -4.002479e-03 -4.175399e-03
## ASV1446      2.519378e-03  2.601527e-03  2.684675e-03  2.768675e-03
## ASV17171    -7.092823e-03 -7.402473e-03 -7.724687e-03 -8.059916e-03
## ASV0533      5.648927e-04  5.929038e-04  6.223179e-04  6.532038e-04
## ASV2495     -1.917928e-03 -2.018954e-03 -2.125591e-03 -2.238158e-03
## ASV5582      3.010919e-03  3.117032e-03  3.225294e-03  3.335614e-03
## ASV1488      1.212455e-03  1.261193e-03  1.311477e-03  1.363320e-03
## ASV0682      1.653891e-03  1.731261e-03  1.812159e-03  1.896737e-03
## ASV0068     -2.795512e-03 -2.918349e-03 -3.046125e-03 -3.179001e-03
## ASV1987     -7.219797e-03 -7.561601e-03 -7.919287e-03 -8.293551e-03
## ASV0035     -6.286083e-04 -6.671342e-04 -7.082148e-04 -7.520266e-04
## ASV7192     -4.232869e-03 -4.410386e-03 -4.594420e-03 -4.785142e-03
## ASV0873     -2.411635e-03 -2.688984e-03 -2.990666e-03 -3.318399e-03
## ASV4749     -4.842073e-04 -5.377283e-04 -5.961534e-04 -6.598694e-04
## ASV2174      2.779618e-03  2.880343e-03  2.983342e-03  3.088546e-03
## ASV1476     -3.178742e-03 -3.327868e-03 -3.483924e-03 -3.647226e-03
## ASV0740     -8.996098e-03 -9.414277e-03 -9.851394e-03 -1.030826e-02
## ASV0170     -1.717792e-03 -1.793688e-03 -1.872699e-03 -1.954934e-03
## ASV2466     -7.840706e-03 -8.188548e-03 -8.550883e-03 -8.928246e-03
## ASV1709      2.782353e-03  2.898308e-03  3.018691e-03  3.143663e-03
## ASV6170     -1.245184e-02 -1.301987e-02 -1.361273e-02 -1.423142e-02
## ASV3673      6.169804e-03  6.456312e-03  6.755755e-03  7.068680e-03
## ASV1745     -1.650131e-03 -1.731563e-03 -1.817058e-03 -1.906818e-03
##                                                                    
## (Intercept)  4.949806e-02  5.164344e-02  5.387245e-02  5.618758e-02
## ASV1236      9.398448e-03  9.777588e-03  1.016947e-02  1.057435e-02
## ASV0421      1.344972e-03  1.421277e-03  1.502020e-03  1.587444e-03
## ASV0691     -6.784401e-03 -7.016100e-03 -7.252180e-03 -7.492464e-03
## ASV0899      8.171141e-03  8.501139e-03  8.841997e-03  9.193874e-03
## ASV1004      1.886935e-02  1.963304e-02  2.042236e-02  2.123778e-02
## ASV1041     -7.696704e-03 -8.001359e-03 -8.315375e-03 -8.638811e-03
## ASV1058      1.176019e-02  1.223533e-02  1.272643e-02  1.323381e-02
## ASV12542     4.455698e-03  4.627585e-03  4.804606e-03  4.986816e-03
## ASV1294      1.096202e-02  1.140630e-02  1.186563e-02  1.234030e-02
## ASV13113     4.019095e-03  4.211549e-03  4.413182e-03  4.624424e-03
## ASV1318      1.091708e-02  1.135807e-02  1.181381e-02  1.228457e-02
## ASV2269     -1.882277e-02 -1.957517e-02 -2.035181e-02 -2.115304e-02
## ASV2542      9.757638e-03  1.019703e-02  1.065519e-02  1.113287e-02
## ASV2660     -7.449543e-03 -7.744392e-03 -8.048554e-03 -8.362147e-03
## ASV2737      2.475237e-03  2.565520e-03  2.658110e-03  2.753003e-03
## ASV2840      9.677424e-03  1.003932e-02  1.041076e-02  1.079166e-02
## ASV3053      5.027628e-02  5.222585e-02  5.423439e-02  5.630255e-02
## ASV3077      3.222939e-03  3.349463e-03  3.479984e-03  3.614567e-03
## ASV3134      6.314076e-03  6.608695e-03  6.916778e-03  7.238913e-03
## ASV3140      8.216585e-03  8.572545e-03  8.942450e-03  9.326727e-03
## ASV3579      3.172547e-03  3.330912e-03  3.497270e-03  3.672016e-03
## ASV6119     -5.149673e-03 -5.355458e-03 -5.567873e-03 -5.787009e-03
## ASV7557     -1.046082e-02 -1.087865e-02 -1.130993e-02 -1.175484e-02
## ASV8422      2.572733e-03  2.673256e-03  2.776918e-03  2.883766e-03
## ASV1086     -3.668105e-04 -3.786054e-04 -3.905953e-04 -4.027749e-04
## ASV1310      5.026626e-03  5.228722e-03  5.437474e-03  5.652992e-03
## ASV15750    -6.389614e-04 -6.608707e-04 -6.831514e-04 -7.057755e-04
## ASV16905    -2.151092e-03 -2.237014e-03 -2.325701e-03 -2.417192e-03
## ASV2033      9.891101e-03  1.034260e-02  1.081368e-02  1.130512e-02
## ASV2089      4.540822e-03  4.722562e-03  4.910178e-03  5.103754e-03
## ASV2127      1.478236e-02  1.537797e-02  1.599340e-02  1.662900e-02
## ASV2725      1.163823e-02  1.209235e-02  1.256032e-02  1.304231e-02
## ASV2804     -4.452315e-03 -4.630144e-03 -4.813699e-03 -5.003057e-03
## ASV3075      1.012290e-02  1.055880e-02  1.101196e-02  1.148299e-02
## ASV3327      1.433203e-02  1.497161e-02  1.563784e-02  1.633171e-02
## ASV3342      1.223676e-02  1.277723e-02  1.333988e-02  1.392549e-02
## ASV3532     -1.334427e-02 -1.392230e-02 -1.452323e-02 -1.514784e-02
## ASV3600      6.232456e-03  6.504583e-03  6.787642e-03  7.082001e-03
## ASV4013      1.134687e-02  1.182025e-02  1.231073e-02  1.281872e-02
## ASV4136      1.173169e-02  1.219431e-02  1.267165e-02  1.316394e-02
## ASV4195      4.543014e-02  4.724391e-02  4.911604e-02  5.104731e-02
## ASV4407     -1.754588e-02 -1.824607e-02 -1.896876e-02 -1.971426e-02
## ASV4717      2.875397e-03  2.977193e-03  3.081308e-03  3.187711e-03
## ASV6794      7.093298e-03  7.364496e-03  7.643705e-03  7.931010e-03
## ASV8324     -9.003181e-03 -9.362453e-03 -9.733266e-03 -1.011578e-02
## ASV8981     -9.285767e-05 -8.604544e-05 -7.804540e-05 -6.874533e-05
## ASV9859      3.639690e-03  3.827310e-03  4.024972e-03  4.233226e-03
## ASV0936      9.226737e-03  9.633215e-03  1.005611e-02  1.049595e-02
## ASV12683    -4.848117e-05 -5.309290e-05 -5.803077e-05 -6.330776e-05
## ASV1293      5.831739e-03  6.064149e-03  6.304057e-03  6.551575e-03
## ASV13055    -4.253619e-05 -3.655953e-05 -2.968837e-05 -2.184186e-05
## ASV17063    -4.665168e-03 -4.851077e-03 -5.042942e-03 -5.240845e-03
## ASV2228      3.803043e-03  3.954527e-03  4.110860e-03  4.272105e-03
## ASV2769      7.398388e-04  7.802091e-04  8.228041e-04  8.677359e-04
## ASV2803      3.973643e-03  4.121545e-03  4.273388e-03  4.429167e-03
## ASV2896      3.526248e-03  3.686241e-03  3.853265e-03  4.027620e-03
## ASV3062      4.459717e-03  4.675988e-03  4.902678e-03  5.140262e-03
## ASV3107      6.498853e-03  6.787304e-03  7.087774e-03  7.400707e-03
## ASV3265      8.318282e-03  8.647653e-03  8.987448e-03  9.337805e-03
## ASV3666      6.330812e-05  6.426798e-05  6.509429e-05  6.576671e-05
## ASV4497      2.900287e-03  3.018529e-03  3.140822e-03  3.267252e-03
## ASV6914     -5.202666e-04 -5.481507e-04 -5.775602e-04 -6.085742e-04
## ASV0576     -9.528860e-03 -9.876662e-03 -1.023312e-02 -1.059816e-02
## ASV0673      1.126370e-02  1.172969e-02  1.221217e-02  1.271153e-02
## ASV0772      5.280814e-03  5.503826e-03  5.735197e-03  5.975168e-03
## ASV0862      8.661040e-04  9.292374e-04  9.968567e-04  1.069242e-03
## ASV0898      4.331665e-03  4.531273e-03  4.739637e-03  4.957092e-03
## ASV0910      4.899474e-03  5.118815e-03  5.347410e-03  5.585606e-03
## ASV0964     -3.651616e-03 -3.788373e-03 -3.928795e-03 -4.072871e-03
## ASV10059     3.613169e-03  3.784284e-03  3.963365e-03  4.150761e-03
## ASV10263    -7.118503e-03 -7.403046e-03 -7.696789e-03 -7.999865e-03
## ASV1088      8.658807e-03  9.041936e-03  9.441048e-03  9.856750e-03
## ASV1101      1.014236e-02  1.054524e-02  1.096095e-02  1.138966e-02
## ASV1183      2.804412e-03  2.925569e-03  3.051483e-03  3.182306e-03
## ASV11956     2.476578e-03  2.566373e-03  2.658384e-03  2.752596e-03
## ASV12774     3.963673e-05  3.259501e-05  2.456898e-05  1.547541e-05
## ASV1321      1.275937e-02  1.333845e-02  1.394255e-02  1.457264e-02
## ASV13793    -4.907176e-03 -5.103258e-03 -5.305673e-03 -5.514510e-03
## ASV14482     2.790235e-04  2.881197e-04  2.974108e-04  3.069003e-04
## ASV15483     2.139924e-03  2.234887e-03  2.333758e-03  2.436669e-03
## ASV2062      9.605961e-03  1.000612e-02  1.042080e-02  1.085038e-02
## ASV2132      8.117308e-03  8.475882e-03  8.849119e-03  9.237521e-03
## ASV2413      7.315069e-03  7.611467e-03  7.917947e-03  8.234719e-03
## ASV2490      2.193753e-02  2.278171e-02  2.365076e-02  2.454488e-02
## ASV2594      2.934533e-03  3.063347e-03  3.197505e-03  3.337214e-03
## ASV2822     -1.296012e-02 -1.347870e-02 -1.401412e-02 -1.456660e-02
## ASV2863      1.365950e-02  1.419830e-02  1.475423e-02  1.532755e-02
## ASV2910      5.036847e-03  5.238073e-03  5.445860e-03  5.660316e-03
## ASV2980      5.759764e-03  6.000500e-03  6.249985e-03  6.508438e-03
## ASV3307      1.030494e-02  1.071688e-02  1.114216e-02  1.158095e-02
## ASV3474      7.384383e-03  7.725084e-03  8.080921e-03  8.452507e-03
## ASV3502      7.422458e-03  7.740908e-03  8.071677e-03  8.415148e-03
## ASV4236      1.023208e-02  1.061855e-02  1.101565e-02  1.142337e-02
## ASV4842     -1.208727e-03 -1.261699e-03 -1.316601e-03 -1.373457e-03
## ASV4894     -4.911458e-03 -5.107978e-03 -5.310875e-03 -5.520245e-03
## ASV5290      4.101000e-03  4.280640e-03  4.467477e-03  4.661745e-03
## ASV5501      2.483702e-03  2.591788e-03  2.704312e-03  2.821449e-03
## ASV5795      2.766351e-03  2.888416e-03  3.015458e-03  3.147647e-03
## ASV5987     -1.372340e-02 -1.427287e-02 -1.484022e-02 -1.542570e-02
## ASV6267     -1.545776e-02 -1.607639e-02 -1.671512e-02 -1.737425e-02
## ASV6862      6.087101e-03  6.322631e-03  6.565275e-03  6.815112e-03
## ASV7145      2.647449e-03  2.747785e-03  2.851120e-03  2.957505e-03
## ASV7673     -4.911055e-03 -5.107574e-03 -5.310475e-03 -5.519854e-03
## ASV7789      2.803329e-03  2.945119e-03  3.094228e-03  3.251032e-03
## ASV7809      3.021362e-04  3.248300e-04  3.491782e-04  3.752874e-04
## ASV8002     -6.202753e-03 -6.451030e-03 -6.707382e-03 -6.971933e-03
## ASV8205      2.721410e-03  2.840364e-03  2.964117e-03  3.092835e-03
## ASV9155     -1.538187e-03 -1.596666e-03 -1.656771e-03 -1.718499e-03
## ASV9221      8.832797e-04  9.383029e-04  9.968969e-04  1.059287e-03
## ASV9311     -9.949261e-03 -1.034752e-02 -1.075873e-02 -1.118311e-02
## ASV9557     -6.797040e-03 -7.068992e-03 -7.349785e-03 -7.639556e-03
## ASV9936     -1.370205e-02 -1.425003e-02 -1.481580e-02 -1.539963e-02
## ASV1445      8.726301e-03  9.107101e-03  9.503107e-03  9.914815e-03
## ASV4232      3.479610e-03  3.646053e-03  3.820515e-03  4.003387e-03
## ASV6479      1.469293e-03  1.555824e-03  1.647683e-03  1.745193e-03
## ASV0142     -5.866767e-03 -6.098664e-03 -6.337925e-03 -6.584656e-03
## ASV0378      2.955275e-03  3.095061e-03  3.241303e-03  3.394276e-03
## ASV1122      8.510691e-03  8.887120e-03  9.279017e-03  9.686923e-03
## ASV0123     -5.169510e-03 -5.372943e-03 -5.582755e-03 -5.799029e-03
## ASV2064      2.512902e-03  2.600800e-03  2.690404e-03  2.781628e-03
## ASV4459     -3.193640e-04 -3.282942e-04 -3.372535e-04 -3.462303e-04
## ASV0448      2.366173e-03  2.478302e-03  2.595630e-03  2.718382e-03
## ASV0397      4.882969e-03  5.089713e-03  5.304187e-03  5.526604e-03
## ASV0485      5.596866e-03  5.828152e-03  6.067669e-03  6.315614e-03
## ASV1566      8.333629e-03  8.684375e-03  9.048060e-03  9.425026e-03
## ASV1365      7.205130e-03  7.514675e-03  7.836073e-03  8.169657e-03
## ASV1065      1.022333e-02  1.066225e-02  1.111812e-02  1.159144e-02
## ASV0722     -5.600126e-04 -5.863943e-04 -6.140379e-04 -6.430072e-04
## ASV12660    -5.582183e-03 -5.800688e-03 -6.025995e-03 -6.258192e-03
## ASV0223      1.555024e-03  1.620113e-03  1.687608e-03  1.757578e-03
## ASV0229      2.459203e-03  2.568771e-03  2.682932e-03  2.801855e-03
## ASV0877      8.946104e-04  9.229934e-04  9.514773e-04  9.799637e-04
## ASV0983      5.516142e-03  5.740641e-03  5.972781e-03  6.212711e-03
## ASV0626      8.326884e-04  8.849120e-04  9.404269e-04  9.994197e-04
## ASV4146      2.559116e-04  2.640473e-04  2.720881e-04  2.799742e-04
## ASV4175     -7.089674e-03 -7.401297e-03 -7.725534e-03 -8.062811e-03
## ASV2082     -3.653862e-03 -3.851154e-03 -4.059611e-03 -4.279872e-03
## ASV2272      3.362536e-03  3.509832e-03  3.663130e-03  3.822644e-03
## ASV2245     -5.093086e-03 -5.319117e-03 -5.554460e-03 -5.799438e-03
## ASV0590     -3.567152e-03 -3.767213e-03 -3.978982e-03 -4.203139e-03
## ASV0217      5.822778e-04  6.318370e-04  6.852832e-04  7.428797e-04
## ASV0416      3.403228e-03  3.519286e-03  3.637367e-03  3.757342e-03
## ASV1056      5.004595e-03  5.232636e-03  5.470526e-03  5.718636e-03
## ASV7777     -6.864469e-03 -7.164190e-03 -7.476005e-03 -7.800337e-03
## ASV0455      1.218463e-03  1.270402e-03  1.324297e-03  1.380198e-03
## ASV0604      3.339497e-03  3.494983e-03  3.657441e-03  3.827154e-03
## ASV6100     -4.799094e-03 -5.014063e-03 -5.238166e-03 -5.471757e-03
## ASV11359    -1.015636e-02 -1.059756e-02 -1.105614e-02 -1.153265e-02
## ASV6604      1.461243e-03  1.528783e-03  1.599319e-03  1.672972e-03
## ASV5004     -3.586004e-03 -3.740187e-03 -3.900392e-03 -4.066811e-03
## ASV1483     -1.530955e-03 -1.595575e-03 -1.662597e-03 -1.732085e-03
## ASV9773     -4.608856e-03 -4.812168e-03 -5.023832e-03 -5.244147e-03
## ASV4059      2.566355e-04  2.866744e-04  3.194370e-04  3.551254e-04
## ASV1193      5.456432e-03  5.688237e-03  5.928797e-03  6.178363e-03
## ASV4610     -5.370864e-04 -5.363501e-04 -5.338280e-04 -5.293539e-04
## ASV0742     -2.412012e-04 -2.306012e-04 -2.179551e-04 -2.030870e-04
## ASV1502     -4.247508e-04 -4.564745e-04 -4.905072e-04 -5.269983e-04
## ASV0195      2.638746e-05  1.961849e-05  1.197403e-05  3.383992e-06
## ASV1213      3.574246e-03  3.705569e-03  3.840195e-03  3.978093e-03
## ASV1648     -4.303009e-03 -4.495403e-03 -4.695975e-03 -4.905046e-03
## ASV6984     -4.032342e-03 -4.213234e-03 -4.401881e-03 -4.598594e-03
## ASV0396     -1.072028e-04 -1.035161e-04 -9.910463e-05 -9.391593e-05
## ASV4297      5.293459e-03  5.496575e-03  5.705569e-03  5.920471e-03
## ASV2622      8.416076e-03  8.755817e-03  9.106955e-03  9.469708e-03
## ASV3512      3.762041e-03  3.953264e-03  4.154493e-03  4.366258e-03
## ASV2411      6.172997e-03  6.456907e-03  6.753373e-03  7.062902e-03
## ASV2291     -3.136080e-03 -3.314861e-03 -3.504209e-03 -3.704729e-03
## ASV0807      8.037640e-03  8.378702e-03  8.732520e-03  9.099432e-03
## ASV1292      1.752934e-03  1.813302e-03  1.874828e-03  1.937462e-03
## ASV1035      7.102844e-03  7.385343e-03  7.677088e-03  7.978251e-03
## ASV0070      1.852443e-04  2.026278e-04  2.214853e-04  2.419268e-04
## ASV0255      6.292466e-04  6.502968e-04  6.716051e-04  6.931267e-04
## ASV0057     -1.885056e-03 -1.954153e-03 -2.024943e-03 -2.097399e-03
## ASV0077     -3.549550e-04 -3.643064e-04 -3.735446e-04 -3.826315e-04
## ASV0625      4.042359e-03  4.198778e-03  4.359852e-03  4.525618e-03
## ASV2464      2.741970e-02  2.847880e-02  2.956988e-02  3.069329e-02
## ASV1315      8.088737e-03  8.464082e-03  8.856278e-03  9.266019e-03
## ASV2673      6.951222e-03  7.274798e-03  7.612991e-03  7.966414e-03
## ASV2161      2.931429e-03  3.067564e-03  3.209868e-03  3.358607e-03
## ASV0337     -1.631206e-03 -1.703302e-03 -1.778352e-03 -1.856460e-03
## ASV7680     -1.069096e-02 -1.116723e-02 -1.166337e-02 -1.218011e-02
## ASV0611      5.985768e-03  6.253828e-03  6.533229e-03  6.824401e-03
## ASV3118     -6.406779e-03 -6.707397e-03 -7.021746e-03 -7.350406e-03
## ASV1284      1.362388e-03  1.359423e-03  1.351155e-03  1.337002e-03
## ASV0889      4.311639e-03  4.489051e-03  4.672764e-03  4.862939e-03
## ASV4649     -2.225063e-03 -2.321455e-03 -2.421661e-03 -2.525807e-03
## ASV1108     -4.876798e-03 -5.112106e-03 -5.358727e-03 -5.617185e-03
## ASV0738      2.876635e-03  3.028445e-03  3.188546e-03  3.357390e-03
## ASV0473     -6.473436e-04 -6.848650e-04 -7.245391e-04 -7.664721e-04
## ASV0598     -1.539440e-03 -1.625608e-03 -1.716863e-03 -1.813510e-03
## ASV0429      3.128204e-03  3.250621e-03  3.376733e-03  3.506563e-03
## ASV1549      6.425751e-03  6.725754e-03  7.039378e-03  7.367200e-03
## ASV1203      4.704373e-03  4.898397e-03  5.099239e-03  5.307050e-03
## ASV4532      1.532701e-04  1.563099e-04  1.592457e-04  1.620667e-04
## ASV0274      9.221057e-04  9.676032e-04  1.015284e-03  1.065237e-03
## ASV0163     -3.499966e-03 -3.634911e-03 -3.773906e-03 -3.916995e-03
## ASV1298      3.398217e-04  3.503385e-04  3.610651e-04  3.720125e-04
## ASV9424     -8.346218e-03 -8.723031e-03 -9.116076e-03 -9.525996e-03
## ASV0412      8.104472e-03  8.434983e-03  8.776867e-03  9.130365e-03
## ASV0284      1.507210e-03  1.554309e-03  1.601768e-03  1.649481e-03
## ASV0620     -1.965939e-03 -2.069236e-03 -2.178089e-03 -2.292791e-03
## ASV0153     -8.583171e-03 -8.982957e-03 -9.400764e-03 -9.837338e-03
## ASV0498      2.939151e-03  3.069106e-03  3.204287e-03  3.344854e-03
## ASV0097      1.686838e-03  1.765580e-03  1.847902e-03  1.933956e-03
## ASV0104     -1.119718e-02 -1.166730e-02 -1.215460e-02 -1.265950e-02
## ASV1282      3.697608e-03  3.840009e-03  3.986430e-03  4.136857e-03
## ASV3883     -3.411039e-03 -3.579443e-03 -3.756107e-03 -3.941408e-03
## ASV0801      1.567852e-03  1.637545e-03  1.710138e-03  1.785738e-03
## ASV1611     -7.563660e-03 -7.910579e-03 -8.272805e-03 -8.650958e-03
## ASV0227     -1.570190e-03 -1.656467e-03 -1.747620e-03 -1.843914e-03
## ASV0833      2.508966e-03  2.619206e-03  2.733883e-03  2.853141e-03
## ASV0718      1.118132e-02  1.167086e-02  1.218015e-02  1.270984e-02
## ASV1139      1.108187e-03  1.132006e-03  1.154731e-03  1.176168e-03
## ASV0766     -1.700993e-03 -1.785169e-03 -1.873473e-03 -1.966095e-03
## ASV2091      8.496710e-03  8.825672e-03  9.164378e-03  9.512893e-03
## ASV1238     -8.495417e-03 -8.882182e-03 -9.286017e-03 -9.707649e-03
## ASV9193     -1.085515e-03 -1.154741e-03 -1.228634e-03 -1.307509e-03
## ASV0290      9.911143e-04  1.021062e-03  1.051239e-03  1.081597e-03
## ASV0231      3.186197e-03  3.315560e-03  3.449284e-03  3.587446e-03
## ASV0185      2.196526e-03  2.311785e-03  2.433298e-03  2.561403e-03
## ASV2330      3.493736e-03  3.624021e-03  3.757763e-03  3.894951e-03
## ASV3119     -1.971522e-03 -2.073682e-03 -2.181273e-03 -2.294580e-03
## ASV2368     -4.468295e-03 -4.679522e-03 -4.900693e-03 -5.132273e-03
## ASV0122     -2.005472e-03 -2.088925e-03 -2.175390e-03 -2.264943e-03
## ASV1044      5.453115e-03  5.703549e-03  5.965068e-03  6.238128e-03
## ASV0160     -2.041100e-03 -2.117905e-03 -2.196831e-03 -2.277883e-03
## ASV0326      5.884573e-04  6.141724e-04  6.408863e-04  6.686253e-04
## ASV1388      1.044372e-02  1.088047e-02  1.133306e-02  1.180187e-02
## ASV0792      7.539048e-03  7.838992e-03  8.148550e-03  8.467856e-03
## ASV0036     -2.575270e-03 -2.695079e-03 -2.820250e-03 -2.950998e-03
## ASV2125      7.524034e-03  7.843020e-03  8.173932e-03  8.517088e-03
## ASV1075     -1.164158e-04 -1.218499e-04 -1.275694e-04 -1.335944e-04
## ASV0390      4.261743e-03  4.461684e-03  4.670868e-03  4.889710e-03
## ASV3790     -5.858607e-03 -6.119208e-03 -6.390662e-03 -6.673365e-03
## ASV1535     -1.861168e-03 -1.956381e-03 -2.056553e-03 -2.161937e-03
## ASV0263      7.059813e-03  7.365280e-03  7.682750e-03  8.012601e-03
## ASV0675      1.089709e-02  1.139008e-02  1.190426e-02  1.244044e-02
## ASV3348      9.357670e-04  9.817567e-04  1.029994e-03  1.080582e-03
## ASV0058     -3.077376e-03 -3.205199e-03 -3.337579e-03 -3.474618e-03
## ASV4142      4.195032e-03  4.359982e-03  4.530018e-03  4.705194e-03
## ASV0059     -2.458204e-03 -2.558742e-03 -2.662727e-03 -2.770227e-03
## ASV0013     -4.495359e-03 -4.688897e-03 -4.889944e-03 -5.098729e-03
## ASV0033     -2.230017e-03 -2.333217e-03 -2.441003e-03 -2.553557e-03
## ASV4354     -2.662535e-03 -2.778951e-03 -2.900132e-03 -3.026256e-03
## ASV0022     -1.881547e-03 -1.968567e-03 -2.059457e-03 -2.154376e-03
## ASV0134     -1.860764e-03 -1.952051e-03 -2.047842e-03 -2.148355e-03
## ASV0415      3.387987e-04  3.576629e-04  3.775512e-04  3.985098e-04
## ASV10103    -1.030200e-02 -1.076846e-02 -1.125500e-02 -1.176238e-02
## ASV1613      7.150349e-03  7.434493e-03  7.727627e-03  8.029854e-03
## ASV0135     -8.804520e-04 -9.124970e-04 -9.453014e-04 -9.788507e-04
## ASV0469     -9.399927e-03 -9.788350e-03 -1.019066e-02 -1.060722e-02
## ASV0471      5.844069e-03  6.094392e-03  6.354349e-03  6.624231e-03
## ASV0451     -1.182317e-03 -1.249812e-03 -1.321292e-03 -1.396987e-03
## ASV0747      3.375022e-03  3.523040e-03  3.676999e-03  3.837091e-03
## ASV1314     -3.543409e-03 -3.711008e-03 -3.886461e-03 -4.070126e-03
## ASV0425     -1.134822e-02 -1.179441e-02 -1.225451e-02 -1.272869e-02
## ASV0559     -2.934731e-03 -3.061104e-03 -3.192557e-03 -3.329280e-03
## ASV0148     -5.124267e-04 -5.226153e-04 -5.321781e-04 -5.410104e-04
## ASV0129      9.841043e-04  1.049087e-03  1.118550e-03  1.192792e-03
## ASV1072      6.882432e-04  7.099019e-04  7.316994e-04  7.535793e-04
## ASV2390      5.669948e-03  5.880626e-03  6.096626e-03  6.317876e-03
## ASV0548      4.005484e-03  4.175680e-03  4.352276e-03  4.535445e-03
## ASV0168     -2.014853e-03 -2.097500e-03 -2.183034e-03 -2.271518e-03
## ASV0066     -2.288324e-03 -2.383281e-03 -2.481594e-03 -2.583335e-03
## ASV0468     -1.244728e-03 -1.299134e-03 -1.355742e-03 -1.414630e-03
## ASV0172     -6.043362e-04 -6.231388e-04 -6.420570e-04 -6.610440e-04
## ASV0236      2.406337e-04  2.789475e-04  3.210779e-04  3.673252e-04
## ASV0250      3.627582e-03  3.809767e-03  4.001293e-03  4.202641e-03
## ASV0338      1.630972e-03  1.705747e-03  1.783699e-03  1.864931e-03
## ASV0450     -3.749236e-04 -3.973392e-04 -4.211586e-04 -4.464692e-04
## ASV0377      2.850704e-03  2.968542e-03  3.090528e-03  3.216749e-03
## ASV1022     -1.043441e-04 -1.070164e-04 -1.095867e-04 -1.120283e-04
## ASV6174     -1.074789e-04 -1.156927e-04 -1.245622e-04 -1.341371e-04
## ASV0786     -5.560989e-04 -5.908377e-04 -6.277570e-04 -6.669808e-04
## ASV0053     -3.170682e-03 -3.308426e-03 -3.451609e-03 -3.600400e-03
## ASV0697     -1.841361e-03 -1.915200e-03 -1.991498e-03 -2.070304e-03
## ASV0785      3.952990e-03  4.116810e-03  4.286454e-03  4.462058e-03
## ASV1967     -3.899040e-03 -4.059199e-03 -4.225033e-03 -4.396683e-03
## ASV0385      1.431512e-03  1.498862e-03  1.569242e-03  1.642767e-03
## ASV0295      3.559134e-04  3.801744e-04  4.061464e-04  4.339459e-04
## ASV0072     -3.018505e-03 -3.139274e-03 -3.263924e-03 -3.392503e-03
## ASV0157     -2.237589e-04 -2.197867e-04 -2.144695e-04 -2.076641e-04
## ASV0501      6.873026e-03  7.173440e-03  7.485823e-03  7.810553e-03
## ASV10729    -8.713992e-03 -9.101142e-03 -9.504346e-03 -9.924178e-03
## ASV1470      4.023079e-03  4.170932e-03  4.322425e-03  4.477504e-03
## ASV0050     -7.252671e-03 -7.554706e-03 -7.867570e-03 -8.191518e-03
## ASV0411     -1.736409e-03 -1.816483e-03 -1.900125e-03 -1.987485e-03
## ASV0549      2.753653e-03  2.877774e-03  3.007174e-03  3.142048e-03
## ASV0184      8.847727e-04  9.223476e-04  9.613837e-04  1.001932e-03
## ASV0705      1.703211e-03  1.771200e-03  1.841348e-03  1.913676e-03
## ASV1715      3.761359e-03  3.924292e-03  4.093622e-03  4.269549e-03
## ASV0603      6.127678e-04  6.417405e-04  6.721224e-04  7.039886e-04
## ASV0826      6.259863e-03  6.524504e-03  6.799036e-03  7.083735e-03
## ASV0034     -1.957615e-03 -2.036641e-03 -2.118284e-03 -2.202587e-03
## ASV0838      9.808645e-04  9.904195e-04  9.974045e-04  1.001476e-03
## ASV0614     -1.711054e-03 -1.783221e-03 -1.858074e-03 -1.935689e-03
## ASV0014     -4.559468e-03 -4.753336e-03 -4.954513e-03 -5.163202e-03
## ASV0585      2.024612e-04  1.882321e-04  1.715586e-04  1.522200e-04
## ASV0016     -4.762843e-03 -4.965350e-03 -5.175492e-03 -5.393481e-03
## ASV5394     -3.631791e-03 -3.790822e-03 -3.956234e-03 -4.128236e-03
## ASV0666      7.503615e-03  7.801426e-03  8.108745e-03  8.425704e-03
## ASV2085      1.295785e-03  1.313540e-03  1.328883e-03  1.341503e-03
## ASV0003     -3.244066e-03 -3.381735e-03 -3.524574e-03 -3.672726e-03
## ASV0346      1.730866e-03  1.811592e-03  1.895912e-03  1.983963e-03
## ASV0267      8.758577e-05  9.894176e-05  1.113482e-04  1.248799e-04
## ASV0353      2.708671e-03  2.832528e-03  2.961802e-03  3.096707e-03
## ASV2419      6.914597e-03  7.203015e-03  7.501870e-03  7.811423e-03
## ASV0447      3.983846e-03  4.166651e-03  4.357461e-03  4.556588e-03
## ASV0654      5.650956e-03  5.891920e-03  6.141996e-03  6.401436e-03
## ASV0151      8.780009e-04  9.251176e-04  9.748662e-04  1.027393e-03
## ASV0065     -2.160107e-03 -2.250265e-03 -2.343683e-03 -2.440440e-03
## ASV0527      5.349214e-03  5.575479e-03  5.810194e-03  6.053590e-03
## ASV4055     -9.445474e-04 -9.926892e-04 -1.043428e-03 -1.096915e-03
## ASV0166     -2.596334e-03 -2.699226e-03 -2.805379e-03 -2.914836e-03
## ASV0417     -1.003225e-03 -1.038326e-03 -1.074123e-03 -1.110585e-03
## ASV0078     -1.550800e-03 -1.613003e-03 -1.677208e-03 -1.743439e-03
## ASV0322     -1.848769e-04 -1.835083e-04 -1.811505e-04 -1.776784e-04
## ASV0156     -3.899474e-03 -4.073271e-03 -4.254364e-03 -4.443024e-03
## ASV0648     -8.513907e-03 -8.896248e-03 -9.294781e-03 -9.710110e-03
## ASV0407     -6.610897e-04 -6.925935e-04 -7.255980e-04 -7.601746e-04
## ASV2030     -1.363520e-03 -1.422144e-03 -1.483255e-03 -1.546973e-03
## ASV0300      1.045870e-03  1.094944e-03  1.146249e-03  1.199877e-03
## ASV1150      2.618621e-04  2.759947e-04  2.908975e-04  3.066092e-04
## ASV0958      3.249019e-03  3.403390e-03  3.565036e-03  3.734292e-03
## ASV0216     -3.319718e-03 -3.458133e-03 -3.601696e-03 -3.750568e-03
## ASV0446      5.243722e-03  5.478588e-03  5.723292e-03  5.978184e-03
## ASV0367     -3.388281e-03 -3.536778e-03 -3.691270e-03 -3.851961e-03
## ASV0200     -2.010376e-03 -2.097988e-03 -2.189079e-03 -2.283758e-03
## ASV0334     -9.120074e-04 -9.389857e-04 -9.660931e-04 -9.932755e-04
## ASV1311      1.162420e-03  1.201122e-03  1.240364e-03  1.280084e-03
## ASV0458      1.694595e-03  1.749676e-03  1.805478e-03  1.861917e-03
## ASV1371      3.480411e-04  3.653329e-04  3.834505e-04  4.024258e-04
## ASV0418      4.228554e-03  4.394542e-03  4.565703e-03  4.742104e-03
## ASV0004      6.080668e-04  6.315314e-04  6.556897e-04  6.805468e-04
## ASV1943      1.067433e-02  1.101685e-02  1.136423e-02  1.171611e-02
## ASV1495     -1.179804e-03 -1.252826e-03 -1.330592e-03 -1.413407e-03
## ASV0901     -3.900170e-03 -4.078616e-03 -4.264953e-03 -4.459511e-03
## ASV0628      1.835550e-03  1.901781e-03  1.969499e-03  2.038657e-03
## ASV0400      1.166956e-03  1.213059e-03  1.260566e-03  1.309484e-03
## ASV0116     -1.142917e-03 -1.194866e-03 -1.249076e-03 -1.305639e-03
## ASV0788      1.013656e-02  1.059985e-02  1.108352e-02  1.158840e-02
## ASV0117      7.746546e-04  8.120113e-04  8.511514e-04  8.921556e-04
## ASV3137     -2.204760e-04 -2.292896e-04 -2.383854e-04 -2.477662e-04
## ASV0001      6.476250e-04  6.721708e-04  6.973975e-04  7.233052e-04
## ASV1651      1.870441e-03  1.943415e-03  2.018618e-03  2.096074e-03
## ASV1692      8.417225e-03  8.799734e-03  9.198839e-03  9.615193e-03
## ASV0660      2.623273e-03  2.713982e-03  2.806284e-03  2.900065e-03
## ASV0508      1.276443e-04  1.318118e-04  1.360381e-04  1.403172e-04
## ASV1660     -1.815175e-03 -1.905839e-03 -2.001001e-03 -2.100865e-03
## ASV0233      2.536049e-03  2.646578e-03  2.761520e-03  2.881020e-03
## ASV1343     -4.775866e-03 -4.991727e-03 -5.216882e-03 -5.451698e-03
## ASV0209      2.172050e-03  2.254841e-03  2.339966e-03  2.427430e-03
## ASV0193     -2.558720e-03 -2.657858e-03 -2.759904e-03 -2.864868e-03
## ASV0357      1.203330e-03  1.268251e-03  1.336879e-03  1.409434e-03
## ASV0198      2.007515e-03  2.090715e-03  2.176907e-03  2.266170e-03
## ASV0007      5.600480e-04  5.803449e-04  6.011193e-04  6.223623e-04
## ASV1772     -7.923952e-04 -8.166513e-04 -8.408582e-04 -8.649105e-04
## ASV0009      4.522723e-04  4.678199e-04  4.836530e-04  4.997564e-04
## ASV0006     -5.893650e-04 -6.175370e-04 -6.470376e-04 -6.779260e-04
## ASV0011     -1.956928e-03 -2.044331e-03 -2.135397e-03 -2.230260e-03
## ASV0015      3.410982e-04  3.527365e-04  3.645757e-04  3.766024e-04
## ASV0017      3.855454e-04  3.988481e-04  4.124021e-04  4.261953e-04
## ASV0235     -1.820893e-03 -1.903072e-03 -1.988752e-03 -2.078067e-03
## ASV0382      1.417783e-03  1.480574e-03  1.545840e-03  1.613643e-03
## ASV2357      5.888258e-03  6.151026e-03  6.424838e-03  6.710106e-03
## ASV0567     -1.158327e-03 -1.211712e-03 -1.267537e-03 -1.325914e-03
## ASV0165      9.805431e-04  1.024019e-03  1.069276e-03  1.116374e-03
## ASV0005      1.385144e-03  1.443796e-03  1.504628e-03  1.567697e-03
## ASV0384     -6.181359e-05 -5.749937e-05 -5.240588e-05 -4.645640e-05
## ASV0002      2.500179e-04  2.600002e-04  2.703161e-04  2.809729e-04
## ASV3017      7.021893e-03  7.295883e-03  7.578161e-03  7.868794e-03
## ASV0091     -1.838751e-04 -1.916854e-04 -1.998172e-04 -2.082859e-04
## ASV0186     -2.811620e-03 -2.932092e-03 -3.057149e-03 -3.186916e-03
## ASV0370      1.456627e-03  1.516496e-03  1.578445e-03  1.642520e-03
## ASV0018      1.781842e-03  1.857872e-03  1.936781e-03  2.018649e-03
## ASV1377      1.722333e-02  1.791100e-02  1.862092e-02  1.935343e-02
## ASV0019      1.871701e-03  1.951759e-03  2.034867e-03  2.121111e-03
## ASV0023     -1.211065e-03 -1.265976e-03 -1.323242e-03 -1.382951e-03
## ASV2194      1.979481e-03  2.072065e-03  2.168914e-03  2.270218e-03
## ASV1155      7.211788e-03  7.502688e-03  7.803592e-03  8.114739e-03
## ASV0510     -1.807865e-03 -1.870593e-03 -1.934567e-03 -1.999745e-03
## ASV2371     -4.340001e-03 -4.514327e-03 -4.694513e-03 -4.880678e-03
## ASV0024     -1.502279e-03 -1.569985e-03 -1.640565e-03 -1.714123e-03
## ASV2452      4.171294e-03  4.322855e-03  4.477949e-03  4.636495e-03
## ASV2332     -1.260812e-02 -1.312590e-02 -1.366211e-02 -1.421723e-02
## ASV2591      3.824964e-03  4.018710e-03  4.221973e-03  4.435151e-03
## ASV0521      3.049368e-03  3.186801e-03  3.330101e-03  3.479491e-03
## ASV5542      2.911665e-03  3.041489e-03  3.176639e-03  3.317293e-03
## ASV0336     -4.648621e-04 -4.927216e-04 -5.222889e-04 -5.536626e-04
## ASV10102     5.378293e-03  5.618864e-03  5.869450e-03  6.130400e-03
## ASV16823    -7.564923e-03 -7.852562e-03 -8.148597e-03 -8.453106e-03
## ASV3104      3.912693e-02  4.061405e-02  4.214454e-02  4.371881e-02
## ASV0781      5.822800e-03  6.070996e-03  6.328652e-03  6.596050e-03
## ASV10899     3.924150e-03  4.129286e-03  4.345356e-03  4.572929e-03
## ASV11222    -1.330787e-02 -1.381365e-02 -1.433419e-02 -1.486963e-02
## ASV11327    -1.194335e-02 -1.239709e-02 -1.286406e-02 -1.334438e-02
## ASV12458    -1.329725e-02 -1.380224e-02 -1.432192e-02 -1.485645e-02
## ASV1636      7.793468e-03  8.109113e-03  8.435409e-03  8.772563e-03
## ASV1890     -5.848578e-03 -6.051086e-03 -6.257953e-03 -6.469098e-03
## ASV2898      1.046687e-02  1.089229e-02  1.133220e-02  1.178688e-02
## ASV8328      2.056664e-03  2.203320e-03  2.360362e-03  2.528470e-03
## ASV0709     -1.185645e-02 -1.235160e-02 -1.286457e-02 -1.339579e-02
## ASV0856      1.045900e-02  1.094320e-02  1.144890e-02  1.197699e-02
## ASV0909      3.509978e-03  3.708344e-03  3.918297e-03  4.140492e-03
## ASV0937     -7.259135e-03 -7.587061e-03 -7.929272e-03 -8.286363e-03
## ASV11390    -1.897299e-02 -1.969342e-02 -2.043483e-02 -2.119741e-02
## ASV11966     5.247413e-03  5.498697e-03  5.761682e-03  6.036861e-03
## ASV12990     3.397564e-03  3.531712e-03  3.670035e-03  3.812581e-03
## ASV14797     4.979416e-03  5.172840e-03  5.372118e-03  5.577314e-03
## ASV14904    -2.722403e-02 -2.825777e-02 -2.932162e-02 -3.041585e-02
## ASV15304     3.427694e-03  3.601251e-03  3.783516e-03  3.974888e-03
## ASV16696    -9.404006e-03 -9.761029e-03 -1.012845e-02 -1.050636e-02
## ASV1690      1.779012e-02  1.861115e-02  1.946789e-02  2.036165e-02
## ASV2029      1.161834e-02  1.210241e-02  1.260405e-02  1.312373e-02
## ASV2834      1.504643e-02  1.570966e-02  1.639980e-02  1.711775e-02
## ASV4003      1.312333e-02  1.376156e-02  1.443099e-02  1.513312e-02
## ASV4064      7.198323e-03  7.519628e-03  7.854255e-03  8.202667e-03
## ASV4294      4.757613e-03  5.001079e-03  5.257198e-03  5.526614e-03
## ASV4609      3.904709e-03  4.065324e-03  4.231623e-03  4.403755e-03
## ASV6283     -8.793954e-03 -9.128054e-03 -9.471911e-03 -9.825620e-03
## ASV6491     -1.259944e-02 -1.307793e-02 -1.357038e-02 -1.407693e-02
## ASV7453      7.003594e-03  7.342117e-03  7.696631e-03  8.067824e-03
## ASV7959      2.800068e-03  2.955459e-03  3.119660e-03  3.293147e-03
## ASV8219      1.088732e-01  1.130081e-01  1.172637e-01  1.216412e-01
## ASV8547     -1.127449e-02 -1.170251e-02 -1.214302e-02 -1.259613e-02
## ASV9319      5.465751e-03  5.717644e-03  5.980711e-03  6.255410e-03
## ASV9382     -2.205582e-02 -2.289306e-02 -2.375471e-02 -2.464102e-02
## ASV11516    -1.472565e-02 -1.528442e-02 -1.585946e-02 -1.645095e-02
## ASV14377    -1.062848e-02 -1.103162e-02 -1.144649e-02 -1.187322e-02
## ASV1867      9.012212e-03  9.415741e-03  9.836222e-03  1.027427e-02
## ASV1895      4.072001e-03  4.218366e-03  4.367856e-03  4.520348e-03
## ASV3168      5.269071e-03  5.471413e-03  5.679498e-03  5.893332e-03
## ASV4449      3.052445e-02  3.183093e-02  3.318834e-02  3.459833e-02
## ASV6596      6.970424e-03  7.316576e-03  7.680093e-03  8.061832e-03
## ASV7492     -5.967762e-04 -5.801742e-04 -5.596786e-04 -5.349406e-04
## ASV9854     -2.238275e-03 -2.321051e-03 -2.406136e-03 -2.493549e-03
## ASV6296      1.782737e-01  1.850334e-01  1.919897e-01  1.991447e-01
## ASV4201      1.521008e-03  1.632526e-03  1.752106e-03  1.880283e-03
## ASV0552      6.203952e-03  6.479132e-03  6.765632e-03  7.063839e-03
## ASV3671     -4.003591e-03 -4.173658e-03 -4.350500e-03 -4.534384e-03
## ASV3529     -6.149910e-04 -6.096374e-04 -6.018306e-04 -5.913630e-04
## ASV1060      1.712838e-03  1.794173e-03  1.879379e-03  1.968642e-03
## ASV0239     -2.014529e-03 -2.087710e-03 -2.162678e-03 -2.239414e-03
## ASV5711     -9.664496e-03 -1.006199e-02 -1.047372e-02 -1.090006e-02
## ASV4152     -1.410800e-02 -1.472116e-02 -1.535876e-02 -1.602161e-02
## ASV1461      6.553936e-03  6.795760e-03  7.043743e-03  7.297837e-03
## ASV2877      3.447182e-03  3.577553e-03  3.711478e-03  3.848948e-03
## ASV0012      6.344885e-04  6.618306e-04  6.902447e-04  7.197655e-04
## ASV9823      6.986214e-04  7.121513e-04  7.247264e-04  7.361867e-04
## ASV0008      6.719102e-04  7.005085e-04  7.302027e-04  7.610267e-04
## ASV7832     -8.371675e-03 -8.741846e-03 -9.127449e-03 -9.529060e-03
## ASV1915     -1.008967e-03 -1.050478e-03 -1.093616e-03 -1.138452e-03
## ASV0055     -8.171434e-04 -8.590979e-04 -9.032505e-04 -9.497144e-04
## ASV0032      2.842929e-04  2.924701e-04  3.006466e-04  3.087999e-04
## ASV2977     -1.165232e-02 -1.215450e-02 -1.267631e-02 -1.321839e-02
## ASV0466      8.685976e-03  9.007730e-03  9.337780e-03  9.676064e-03
## ASV3866      6.603643e-03  6.903934e-03  7.217296e-03  7.544251e-03
## ASV0040      2.338886e-03  2.441632e-03  2.548548e-03  2.659777e-03
## ASV0496     -8.318746e-04 -8.895359e-04 -9.512257e-04 -1.017204e-03
## ASV0052      1.966424e-03  2.052986e-03  2.143072e-03  2.236803e-03
## ASV3828     -6.292290e-03 -6.529104e-03 -6.772654e-03 -7.022990e-03
## ASV1930      3.321924e-03  3.452850e-03  3.587769e-03  3.726708e-03
## ASV2126      5.809818e-03  6.052214e-03  6.303445e-03  6.563743e-03
## ASV0793      7.437978e-03  7.772433e-03  8.121054e-03  8.484364e-03
## ASV0299     -1.641287e-04 -1.736814e-04 -1.839412e-04 -1.949740e-04
## ASV0208      5.295489e-03  5.528323e-03  5.770671e-03  6.022870e-03
## ASV0511     -1.965465e-03 -2.035407e-03 -2.106889e-03 -2.179873e-03
## ASV1123     -6.032098e-03 -6.255105e-03 -6.483954e-03 -6.718626e-03
## ASV0099      2.343409e-04  2.477129e-04  2.619208e-04  2.770206e-04
## ASV0752     -3.923922e-03 -4.107877e-03 -4.300210e-03 -4.501275e-03
## ASV0883      5.353756e-03  5.602395e-03  5.862128e-03  6.133398e-03
## ASV0683      6.923207e-03  7.239598e-03  7.569798e-03  7.914349e-03
## ASV4117     -1.077275e-02 -1.124771e-02 -1.174231e-02 -1.225730e-02
## ASV2172      5.676112e-04  5.821609e-04  5.964231e-04  6.103179e-04
## ASV0330     -2.032048e-03 -2.122909e-03 -2.217605e-03 -2.316282e-03
## ASV0728      9.793955e-03  1.021172e-02  1.064532e-02  1.109519e-02
## ASV0499      2.708171e-03  2.833158e-03  2.963718e-03  3.100081e-03
## ASV0120     -4.355028e-03 -4.541563e-03 -4.735202e-03 -4.936143e-03
## ASV1446      2.853363e-03  2.938560e-03  3.024065e-03  3.109659e-03
## ASV17171    -8.408622e-03 -8.771281e-03 -9.148385e-03 -9.540440e-03
## ASV0533      6.856334e-04  7.196813e-04  7.554255e-04  7.929470e-04
## ASV2495     -2.356997e-03 -2.482462e-03 -2.614931e-03 -2.754795e-03
## ASV5582      3.447888e-03  3.561999e-03  3.677814e-03  3.795187e-03
## ASV1488      1.416728e-03  1.471705e-03  1.528250e-03  1.586356e-03
## ASV0682      1.985150e-03  2.077559e-03  2.174131e-03  2.275038e-03
## ASV0068     -3.317137e-03 -3.460695e-03 -3.609838e-03 -3.764728e-03
## ASV1987     -8.685116e-03 -9.094730e-03 -9.523169e-03 -9.971233e-03
## ASV0035     -7.987579e-04 -8.486100e-04 -9.017970e-04 -9.585475e-04
## ASV7192     -4.982719e-03 -5.187319e-03 -5.399109e-03 -5.618254e-03
## ASV0873     -3.673985e-03 -4.059311e-03 -4.476353e-03 -4.927172e-03
## ASV4749     -7.292872e-04 -8.048437e-04 -8.870020e-04 -9.762527e-04
## ASV2174      3.195875e-03  3.305237e-03  3.416523e-03  3.529612e-03
## ASV1476     -3.818102e-03 -3.996896e-03 -4.183965e-03 -4.379683e-03
## ASV0740     -1.078571e-02 -1.128463e-02 -1.180592e-02 -1.235051e-02
## ASV0170     -2.040505e-03 -2.129528e-03 -2.222120e-03 -2.318399e-03
## ASV2466     -9.321191e-03 -9.730287e-03 -1.015612e-02 -1.059928e-02
## ASV1709      3.273394e-03  3.408063e-03  3.547861e-03  3.692987e-03
## ASV6170     -1.487697e-02 -1.555043e-02 -1.625290e-02 -1.698552e-02
## ASV3673      7.395655e-03  7.737267e-03  8.094123e-03  8.466853e-03
## ASV1745     -2.001051e-03 -2.099975e-03 -2.203819e-03 -2.312820e-03
##                                                                    
## (Intercept)  5.859132e-02  6.108619e-02  6.367468e-02  6.635932e-02
## ASV1236      1.099246e-02  1.142405e-02  1.186934e-02  1.232855e-02
## ASV0421      1.677802e-03  1.773356e-03  1.874379e-03  1.981151e-03
## ASV0691     -7.736756e-03 -7.984841e-03 -8.236485e-03 -8.491437e-03
## ASV0899      9.556920e-03  9.931270e-03  1.031705e-02  1.071435e-02
## ASV1004      2.207976e-02  2.294874e-02  2.384512e-02  2.476930e-02
## ASV1041     -8.971708e-03 -9.314084e-03 -9.665931e-03 -1.002722e-02
## ASV1058      1.375775e-02  1.429855e-02  1.485649e-02  1.543184e-02
## ASV12542     5.174260e-03  5.366982e-03  5.565019e-03  5.768403e-03
## ASV1294      1.283062e-02  1.333686e-02  1.385930e-02  1.439823e-02
## ASV13113     4.845719e-03  5.077534e-03  5.320352e-03  5.574679e-03
## ASV1318      1.277061e-02  1.327219e-02  1.378954e-02  1.432288e-02
## ASV2269     -2.197915e-02 -2.283041e-02 -2.370705e-02 -2.460928e-02
## ASV2542      1.163080e-02  1.214976e-02  1.269054e-02  1.325396e-02
## ASV2660     -8.685278e-03 -9.018045e-03 -9.360532e-03 -9.712809e-03
## ASV2737      2.850194e-03  2.949674e-03  3.051429e-03  3.155447e-03
## ASV2840      1.118196e-02  1.158154e-02  1.199026e-02  1.240796e-02
## ASV3053      5.843090e-02  6.061995e-02  6.287017e-02  6.518195e-02
## ASV3077      3.753273e-03  3.896162e-03  4.043292e-03  4.194720e-03
## ASV3134      7.575714e-03  7.927816e-03  8.295883e-03  8.680601e-03
## ASV3140      9.725808e-03  1.014013e-02  1.057012e-02  1.101623e-02
## ASV3579      3.855558e-03  4.048324e-03  4.250757e-03  4.463318e-03
## ASV6119     -6.012950e-03 -6.245768e-03 -6.485529e-03 -6.732288e-03
## ASV7557     -1.221354e-02 -1.268620e-02 -1.317292e-02 -1.367383e-02
## ASV8422      2.993846e-03  3.107201e-03  3.223876e-03  3.343910e-03
## ASV1086     -4.151390e-04 -4.276829e-04 -4.404025e-04 -4.532946e-04
## ASV1310      5.875382e-03  6.104740e-03  6.341160e-03  6.584725e-03
## ASV15750    -7.287114e-04 -7.519241e-04 -7.753743e-04 -7.990190e-04
## ASV16905    -2.511521e-03 -2.608719e-03 -2.708812e-03 -2.811823e-03
## ASV2033      1.181767e-02  1.235212e-02  1.290928e-02  1.348998e-02
## ASV2089      5.303363e-03  5.509075e-03  5.720947e-03  5.939031e-03
## ASV2127      1.728513e-02  1.796211e-02  1.866026e-02  1.937989e-02
## ASV2725      1.353843e-02  1.404879e-02  1.457348e-02  1.511257e-02
## ASV2804     -5.198292e-03 -5.399466e-03 -5.606638e-03 -5.819854e-03
## ASV3075      1.197251e-02  1.248114e-02  1.300956e-02  1.355843e-02
## ASV3327      1.705417e-02  1.780622e-02  1.858887e-02  1.940317e-02
## ASV3342      1.453486e-02  1.516879e-02  1.582814e-02  1.651374e-02
## ASV3532     -1.579689e-02 -1.647119e-02 -1.717155e-02 -1.789881e-02
## ASV3600      7.388036e-03  7.706131e-03  8.036677e-03  8.380071e-03
## ASV4013      1.334466e-02  1.388894e-02  1.445197e-02  1.503414e-02
## ASV4136      1.367139e-02  1.419422e-02  1.473261e-02  1.528676e-02
## ASV4195      5.303846e-02  5.509015e-02  5.720293e-02  5.937731e-02
## ASV4407     -2.048284e-02 -2.127476e-02 -2.209022e-02 -2.292943e-02
## ASV4717      3.296366e-03  3.407234e-03  3.520270e-03  3.635427e-03
## ASV6794      8.226496e-03  8.530236e-03  8.842303e-03  9.162761e-03
## ASV8324     -1.051013e-02 -1.091646e-02 -1.133487e-02 -1.176545e-02
## ASV8981     -5.802543e-05 -4.575803e-05 -3.180734e-05 -1.602918e-05
## ASV9859      4.452653e-03  4.683863e-03  4.927499e-03  5.184234e-03
## ASV0936      1.095327e-02  1.142863e-02  1.192256e-02  1.243561e-02
## ASV12683    -6.893606e-05 -7.492687e-05 -8.129017e-05 -8.803444e-05
## ASV1293      6.806810e-03  7.069859e-03  7.340812e-03  7.619750e-03
## ASV13055    -1.293393e-05 -2.873178e-06  8.437310e-06  2.110007e-05
## ASV17063    -5.444858e-03 -5.655046e-03 -5.871467e-03 -6.094170e-03
## ASV2228      4.438322e-03  4.609565e-03  4.785878e-03  4.967300e-03
## ASV2769      9.151208e-04  9.650782e-04  1.017731e-03  1.073205e-03
## ASV2803      4.588870e-03  4.752479e-03  4.919966e-03  5.091297e-03
## ASV2896      4.209614e-03  4.399574e-03  4.597835e-03  4.804750e-03
## ASV3062      5.389235e-03  5.650109e-03  5.923413e-03  6.209692e-03
## ASV3107      7.726560e-03  8.065804e-03  8.418923e-03  8.786415e-03
## ASV3265      9.698849e-03  1.007069e-02  1.045344e-02  1.084718e-02
## ASV3666      6.626315e-05  6.655957e-05  6.662998e-05  6.644630e-05
## ASV4497      3.397898e-03  3.532839e-03  3.672153e-03  3.815914e-03
## ASV6914     -6.412748e-04 -6.757474e-04 -7.120801e-04 -7.503644e-04
## ASV0576     -1.097169e-02 -1.135360e-02 -1.174374e-02 -1.214195e-02
## ASV0673      1.322813e-02  1.376234e-02  1.431451e-02  1.488502e-02
## ASV0772      6.223982e-03  6.481886e-03  6.749128e-03  7.025962e-03
## ASV0862      1.146685e-03  1.229489e-03  1.317969e-03  1.412450e-03
## ASV0898      5.183980e-03  5.420650e-03  5.667460e-03  5.924771e-03
## ASV0910      5.833757e-03  6.092228e-03  6.361395e-03  6.641641e-03
## ASV0964     -4.220585e-03 -4.371911e-03 -4.526814e-03 -4.685250e-03
## ASV10059     4.346837e-03  4.551968e-03  4.766544e-03  4.990967e-03
## ASV10263    -8.312396e-03 -8.634494e-03 -8.966262e-03 -9.307786e-03
## ASV1088      1.028967e-02  1.074045e-02  1.120978e-02  1.169833e-02
## ASV1101      1.183154e-02  1.228671e-02  1.275532e-02  1.323746e-02
## ASV1183      3.318195e-03  3.459306e-03  3.605801e-03  3.757844e-03
## ASV11956     2.848990e-03  2.947543e-03  3.048226e-03  3.151011e-03
## ASV12774     5.226443e-06 -6.270518e-06 -1.911280e-05 -3.340247e-05
## ASV1321      1.522970e-02  1.591477e-02  1.662888e-02  1.737313e-02
## ASV13793    -5.729853e-03 -5.951779e-03 -6.180355e-03 -6.415642e-03
## ASV14482     3.165929e-04  3.264945e-04  3.366122e-04  3.469548e-04
## ASV15483     2.543757e-03  2.655161e-03  2.771021e-03  2.891479e-03
## ASV2062      1.129523e-02  1.175573e-02  1.223225e-02  1.272518e-02
## ASV2132      9.641602e-03  1.006188e-02  1.049890e-02  1.095318e-02
## ASV2413      8.561991e-03  8.899965e-03  9.248844e-03  9.608825e-03
## ASV2490      2.546423e-02  2.640893e-02  2.737907e-02  2.837471e-02
## ASV2594      3.482691e-03  3.634160e-03  3.791855e-03  3.956020e-03
## ASV2822     -1.513639e-02 -1.572370e-02 -1.632872e-02 -1.695162e-02
## ASV2863      1.591852e-02  1.652736e-02  1.715432e-02  1.779959e-02
## ASV2910      5.881544e-03  6.109643e-03  6.344705e-03  6.586819e-03
## ASV2980      6.776080e-03  7.053130e-03  7.339805e-03  7.636322e-03
## ASV3307      1.203346e-02  1.249983e-02  1.298022e-02  1.347475e-02
## ASV3474      8.840472e-03  9.245469e-03  9.668166e-03  1.010925e-02
## ASV3502      8.771705e-03  9.141742e-03  9.525657e-03  9.923853e-03
## ASV4236      1.184170e-02  1.227059e-02  1.270997e-02  1.315974e-02
## ASV4842     -1.432287e-03 -1.493103e-03 -1.555915e-03 -1.620721e-03
## ASV4894     -5.736176e-03 -5.958750e-03 -6.188042e-03 -6.424117e-03
## ASV5290      4.863679e-03  5.073520e-03  5.291508e-03  5.517888e-03
## ASV5501      2.943379e-03  3.070294e-03  3.202393e-03  3.339883e-03
## ASV5795      3.285153e-03  3.428152e-03  3.576823e-03  3.731344e-03
## ASV5987     -1.602958e-02 -1.665209e-02 -1.729345e-02 -1.795385e-02
## ASV6267     -1.805406e-02 -1.875482e-02 -1.947676e-02 -2.022011e-02
## ASV6862      7.072216e-03  7.336650e-03  7.608475e-03  7.887741e-03
## ASV7145      3.066990e-03  3.179627e-03  3.295468e-03  3.414567e-03
## ASV7673     -5.735801e-03 -5.958399e-03 -6.187725e-03 -6.423845e-03
## ASV7789      3.415923e-03  3.589308e-03  3.771615e-03  3.963290e-03
## ASV7809      4.032689e-04  4.332391e-04  4.653190e-04  4.996342e-04
## ASV8002     -7.244798e-03 -7.526085e-03 -7.815894e-03 -8.114312e-03
## ASV8205      3.226686e-03  3.365843e-03  3.510482e-03  3.660783e-03
## ASV9155     -1.781847e-03 -1.846806e-03 -1.913363e-03 -1.981501e-03
## ASV9221      1.125708e-03  1.196410e-03  1.271654e-03  1.351714e-03
## ASV9311     -1.162085e-02 -1.207211e-02 -1.253705e-02 -1.301584e-02
## ASV9557     -7.938431e-03 -8.246531e-03 -8.563963e-03 -8.890827e-03
## ASV9936     -1.600179e-02 -1.662250e-02 -1.726199e-02 -1.792046e-02
## ASV1445      1.034273e-02  1.078737e-02  1.124924e-02  1.172889e-02
## ASV4232      4.195081e-03  4.396030e-03  4.606688e-03  4.827530e-03
## ASV6479      1.848697e-03  1.958553e-03  2.075138e-03  2.198851e-03
## ASV0142     -6.838955e-03 -7.100917e-03 -7.370628e-03 -7.648164e-03
## ASV0378      3.554262e-03  3.721553e-03  3.896446e-03  4.079249e-03
## ASV1122      1.011139e-02  1.055299e-02  1.101230e-02  1.148991e-02
## ASV0123     -6.021843e-03 -6.251269e-03 -6.487372e-03 -6.730207e-03
## ASV2064      2.874373e-03  2.968529e-03  3.063970e-03  3.160556e-03
## ASV4459     -3.552135e-04 -3.641932e-04 -3.731610e-04 -3.821105e-04
## ASV0448      2.846789e-03  2.981091e-03  3.121536e-03  3.268377e-03
## ASV0397      5.757176e-03  5.996115e-03  6.243632e-03  6.499938e-03
## ASV0485      6.572186e-03  6.837582e-03  7.111998e-03  7.395627e-03
## ASV1566      9.815613e-03  1.022016e-02  1.063901e-02  1.107249e-02
## ASV1365      8.515758e-03  8.874706e-03  9.246830e-03  9.632453e-03
## ASV1065      1.208273e-02  1.259251e-02  1.312131e-02  1.366966e-02
## ASV0722     -6.733702e-04 -7.051983e-04 -7.385673e-04 -7.735573e-04
## ASV12660    -6.497363e-03 -6.743581e-03 -6.996917e-03 -7.257429e-03
## ASV0223      1.830092e-03  1.905219e-03  1.983032e-03  2.063604e-03
## ASV0229      2.925717e-03  3.054699e-03  3.188986e-03  3.328770e-03
## ASV0877      1.008342e-03  1.036487e-03  1.064262e-03  1.091512e-03
## ASV0983      6.460576e-03  6.716514e-03  6.980660e-03  7.253140e-03
## ASV0626      1.062084e-03  1.128622e-03  1.199239e-03  1.274151e-03
## ASV4146      2.876369e-04  2.949979e-04  3.019681e-04  3.084468e-04
## ASV4175     -8.413557e-03 -8.778212e-03 -9.157220e-03 -9.551033e-03
## ASV2082     -4.512613e-03 -4.758542e-03 -5.018406e-03 -5.292986e-03
## ASV2272      3.988595e-03  4.161209e-03  4.340720e-03  4.527367e-03
## ASV2245     -6.054380e-03 -6.319623e-03 -6.595508e-03 -6.882382e-03
## ASV0590     -4.440396e-03 -4.691505e-03 -4.957249e-03 -5.238454e-03
## ASV0217      8.049031e-04  8.716430e-04  9.434023e-04  1.020497e-03
## ASV0416      3.879065e-03  4.002377e-03  4.127101e-03  4.253041e-03
## ASV1056      5.977347e-03  6.247046e-03  6.528131e-03  6.821005e-03
## ASV7777     -8.137619e-03 -8.488295e-03 -8.852824e-03 -9.231677e-03
## ASV0455      1.438158e-03  1.498226e-03  1.560454e-03  1.624890e-03
## ASV0604      4.004409e-03  4.189506e-03  4.382749e-03  4.584451e-03
## ASV6100     -5.715204e-03 -5.968885e-03 -6.233193e-03 -6.508533e-03
## ASV11359    -1.202764e-02 -1.254165e-02 -1.307524e-02 -1.362897e-02
## ASV6604      1.749864e-03  1.830121e-03  1.913871e-03  2.001246e-03
## ASV5004     -4.239644e-03 -4.419092e-03 -4.605364e-03 -4.798669e-03
## ASV1483     -1.804106e-03 -1.878723e-03 -1.956003e-03 -2.036011e-03
## ASV9773     -5.473418e-03 -5.711962e-03 -5.960100e-03 -6.218165e-03
## ASV4059      3.939526e-04  4.361427e-04  4.819307e-04  5.315629e-04
## ASV1193      6.437186e-03  6.705522e-03  6.983628e-03  7.271760e-03
## ASV4610     -5.227549e-04 -5.138507e-04 -5.024547e-04 -4.883738e-04
## ASV0742     -1.858126e-04 -1.659385e-04 -1.432636e-04 -1.175781e-04
## ASV1502     -5.661038e-04 -6.079868e-04 -6.528171e-04 -7.007713e-04
## ASV0195     -6.225359e-06 -1.693145e-05 -2.881540e-05 -4.196202e-05
## ASV1213      4.119221e-03  4.263531e-03  4.410960e-03  4.561439e-03
## ASV1648     -5.122952e-03 -5.350037e-03 -5.586662e-03 -5.833200e-03
## ASV6984     -4.803697e-03 -5.017528e-03 -5.240437e-03 -5.472787e-03
## ASV0396     -8.789689e-05 -8.099407e-05 -7.315419e-05 -6.432460e-05
## ASV4297      6.141299e-03  6.368061e-03  6.600755e-03  6.839366e-03
## ASV2622      9.844287e-03  1.023090e-02  1.062974e-02  1.104100e-02
## ASV3512      4.589117e-03  4.823653e-03  5.070480e-03  5.330242e-03
## ASV2411      7.386016e-03  7.723254e-03  8.075170e-03  8.442333e-03
## ASV2291     -3.917057e-03 -4.141859e-03 -4.379828e-03 -4.631689e-03
## ASV0807      9.479776e-03  9.873889e-03  1.028210e-02  1.070475e-02
## ASV1292      2.001148e-03  2.065826e-03  2.131430e-03  2.197885e-03
## ASV1035      8.289000e-03  8.609499e-03  8.939910e-03  9.280389e-03
## ASV0070      2.640689e-04  2.880349e-04  3.139551e-04  3.419669e-04
## ASV0255      7.148106e-04  7.365993e-04  7.584287e-04  7.802269e-04
## ASV0057     -2.171490e-03 -2.247180e-03 -2.324423e-03 -2.403168e-03
## ASV0077     -3.915265e-04 -4.001864e-04 -4.085654e-04 -4.166154e-04
## ASV0625      4.696105e-03  4.871336e-03  5.051324e-03  5.236076e-03
## ASV2464      3.184937e-02  3.303839e-02  3.426060e-02  3.551621e-02
## ASV1315      9.694026e-03  1.014104e-02  1.060782e-02  1.109516e-02
## ASV2673      8.335700e-03  8.721503e-03  9.124498e-03  9.545382e-03
## ASV2161      3.514056e-03  3.676504e-03  3.846246e-03  4.023593e-03
## ASV0337     -1.937731e-03 -2.022272e-03 -2.110194e-03 -2.201608e-03
## ASV7680     -1.271817e-02 -1.327832e-02 -1.386134e-02 -1.446802e-02
## ASV0611      7.127787e-03  7.443842e-03  7.773036e-03  8.115851e-03
## ASV3118     -7.693980e-03 -8.053087e-03 -8.428368e-03 -8.820483e-03
## ASV1284      1.316337e-03  1.288490e-03  1.252745e-03  1.208340e-03
## ASV0889      5.059735e-03  5.263313e-03  5.473836e-03  5.691467e-03
## ASV4649     -2.634020e-03 -2.746430e-03 -2.863172e-03 -2.984381e-03
## ASV1108     -5.888026e-03 -6.171820e-03 -6.469155e-03 -6.780643e-03
## ASV0738      3.535453e-03  3.723233e-03  3.921252e-03  4.130056e-03
## ASV0473     -8.107731e-04 -8.575529e-04 -9.069244e-04 -9.590015e-04
## ASV0598     -1.915868e-03 -2.024278e-03 -2.139095e-03 -2.260695e-03
## ASV0429      3.640130e-03  3.777443e-03  3.918505e-03  4.063309e-03
## ASV1549      7.709814e-03  8.067833e-03  8.441893e-03  8.832646e-03
## ASV1203      5.521979e-03  5.744169e-03  5.973762e-03  6.210894e-03
## ASV4532      1.647625e-04  1.673235e-04  1.697410e-04  1.720078e-04
## ASV0274      1.117555e-03  1.172330e-03  1.229655e-03  1.289624e-03
## ASV0163     -4.064223e-03 -4.215628e-03 -4.371247e-03 -4.531114e-03
## ASV1298      3.831947e-04  3.946300e-04  4.063411e-04  4.183560e-04
## ASV9424     -9.953456e-03 -1.039914e-02 -1.086377e-02 -1.134806e-02
## ASV0412      9.495709e-03  9.873131e-03  1.026285e-02  1.066509e-02
## ASV0284      1.697332e-03  1.745192e-03  1.792924e-03  1.840374e-03
## ASV0620     -2.413644e-03 -2.540967e-03 -2.675088e-03 -2.816352e-03
## ASV0153     -1.029344e-02 -1.076988e-02 -1.126745e-02 -1.178699e-02
## ASV0498      3.490963e-03  3.642773e-03  3.800440e-03  3.964118e-03
## ASV0097      2.023899e-03  2.117893e-03  2.216107e-03  2.318712e-03
## ASV0104     -1.318243e-02 -1.372379e-02 -1.428402e-02 -1.486349e-02
## ASV1282      4.291265e-03  4.449613e-03  4.611845e-03  4.777889e-03
## ASV3883     -4.135737e-03 -4.339496e-03 -4.553101e-03 -4.776978e-03
## ASV0801      1.864456e-03  1.946408e-03  2.031713e-03  2.120494e-03
## ASV1611     -9.045681e-03 -9.457635e-03 -9.887506e-03 -1.033600e-02
## ASV0227     -1.945629e-03 -2.053056e-03 -2.166498e-03 -2.286272e-03
## ASV0833      2.977127e-03  3.105990e-03  3.239880e-03  3.378949e-03
## ASV0718      1.326062e-02  1.383318e-02  1.442823e-02  1.504647e-02
## ASV1139      1.196103e-03  1.214308e-03  1.230539e-03  1.244532e-03
## ASV0766     -2.063227e-03 -2.165071e-03 -2.271833e-03 -2.383725e-03
## ASV2091      9.871261e-03  1.023951e-02  1.061766e-02  1.100568e-02
## ASV1238     -1.014784e-02 -1.060737e-02 -1.108707e-02 -1.158781e-02
## ASV9193     -1.391701e-03 -1.481562e-03 -1.577467e-03 -1.679813e-03
## ASV0290      1.112084e-03  1.142647e-03  1.173232e-03  1.203782e-03
## ASV0231      3.730120e-03  3.877375e-03  4.029277e-03  4.185883e-03
## ASV0185      2.696457e-03  2.838832e-03  2.988920e-03  3.147130e-03
## ASV2330      4.035570e-03  4.179595e-03  4.326994e-03  4.477730e-03
## ASV3119     -2.413902e-03 -2.539551e-03 -2.671854e-03 -2.811151e-03
## ASV2368     -5.374750e-03 -5.628633e-03 -5.894455e-03 -6.172774e-03
## ASV0122     -2.357659e-03 -2.453614e-03 -2.552881e-03 -2.655535e-03
## ASV1044      6.523198e-03  6.820765e-03  7.131331e-03  7.455415e-03
## ASV0160     -2.361063e-03 -2.446371e-03 -2.533803e-03 -2.623354e-03
## ASV0326      6.974146e-04  7.272789e-04  7.582418e-04  7.903255e-04
## ASV1388      1.228729e-02  1.278968e-02  1.330944e-02  1.384691e-02
## ASV0792      8.797033e-03  9.136196e-03  9.485443e-03  9.844863e-03
## ASV0036     -3.087544e-03 -3.230113e-03 -3.378937e-03 -3.534252e-03
## ASV2125      8.872808e-03  9.241409e-03  9.623208e-03  1.001852e-02
## ASV1075     -1.399467e-04 -1.466503e-04 -1.537317e-04 -1.612193e-04
## ASV0390      5.118643e-03  5.358117e-03  5.608600e-03  5.870582e-03
## ASV3790     -6.967722e-03 -7.274148e-03 -7.593069e-03 -7.924922e-03
## ASV1535     -2.272794e-03 -2.389397e-03 -2.512030e-03 -2.640986e-03
## ASV0263      8.355219e-03  8.710994e-03  9.080322e-03  9.463602e-03
## ASV0675      1.299946e-02  1.358218e-02  1.418950e-02  1.482232e-02
## ASV3348      1.133627e-03  1.189240e-03  1.247534e-03  1.308627e-03
## ASV0058     -3.616419e-03 -3.763082e-03 -3.914705e-03 -4.071381e-03
## ASV4142      4.885557e-03  5.071148e-03  5.262001e-03  5.458143e-03
## ASV0059     -2.881306e-03 -2.996027e-03 -3.114447e-03 -3.236623e-03
## ASV0013     -5.315482e-03 -5.540437e-03 -5.773827e-03 -6.015889e-03
## ASV0033     -2.671066e-03 -2.793723e-03 -2.921725e-03 -3.055273e-03
## ASV4354     -3.157504e-03 -3.294064e-03 -3.436132e-03 -3.583907e-03
## ASV0022     -2.253482e-03 -2.356941e-03 -2.464921e-03 -2.577598e-03
## ASV0134     -2.253817e-03 -2.364467e-03 -2.480555e-03 -2.602340e-03
## ASV0415      4.205858e-04  4.438267e-04  4.682808e-04  4.939963e-04
## ASV10103    -1.229142e-02 -1.284294e-02 -1.341777e-02 -1.401678e-02
## ASV1613      8.341263e-03  8.661929e-03  8.991909e-03  9.331245e-03
## ASV0135     -1.013128e-03 -1.048111e-03 -1.083779e-03 -1.120102e-03
## ASV0469     -1.103838e-02 -1.148449e-02 -1.194591e-02 -1.242301e-02
## ASV0471      6.904335e-03  7.194963e-03  7.496418e-03  7.809011e-03
## ASV0451     -1.477132e-03 -1.561978e-03 -1.651783e-03 -1.746817e-03
## ASV0747      4.003508e-03  4.176448e-03  4.356108e-03  4.542687e-03
## ASV1314     -4.262379e-03 -4.463611e-03 -4.674227e-03 -4.894652e-03
## ASV0425     -1.321710e-02 -1.371989e-02 -1.423716e-02 -1.476904e-02
## ASV0559     -3.471474e-03 -3.619347e-03 -3.773118e-03 -3.933016e-03
## ASV0148     -5.489993e-04 -5.560226e-04 -5.619489e-04 -5.666371e-04
## ASV0129      1.272135e-03  1.356915e-03  1.447489e-03  1.544233e-03
## ASV1072      7.754790e-04  7.973297e-04  8.190556e-04  8.405741e-04
## ASV2390      6.544282e-03  6.775731e-03  7.012085e-03  7.253183e-03
## ASV0548      4.725365e-03  4.922210e-03  5.126154e-03  5.337373e-03
## ASV0168     -2.363017e-03 -2.457594e-03 -2.555313e-03 -2.656235e-03
## ASV0066     -2.688575e-03 -2.797379e-03 -2.909812e-03 -3.025934e-03
## ASV0468     -1.475876e-03 -1.539563e-03 -1.605776e-03 -1.674599e-03
## ASV0172     -6.800482e-04 -6.990128e-04 -7.178762e-04 -7.365710e-04
## ASV0236      4.180078e-04  4.734619e-04  5.340428e-04  6.001244e-04
## ASV0250      4.414312e-03  4.636831e-03  4.870749e-03  5.116640e-03
## ASV0338      1.949548e-03  2.037655e-03  2.129354e-03  2.224749e-03
## ASV0450     -4.733633e-04 -5.019382e-04 -5.322965e-04 -5.645466e-04
## ASV0377      3.347292e-03  3.482240e-03  3.621672e-03  3.765666e-03
## ASV1022     -1.143108e-04 -1.164007e-04 -1.182604e-04 -1.198482e-04
## ASV6174     -1.444703e-04 -1.556179e-04 -1.676387e-04 -1.805947e-04
## ASV0786     -7.086380e-04 -7.528622e-04 -7.997917e-04 -8.495693e-04
## ASV0053     -3.754974e-03 -3.915505e-03 -4.082172e-03 -4.255151e-03
## ASV0697     -2.151666e-03 -2.235632e-03 -2.322249e-03 -2.411562e-03
## ASV0785      4.643754e-03  4.831674e-03  5.025945e-03  5.226695e-03
## ASV1967     -4.574288e-03 -4.757990e-03 -4.947929e-03 -5.144244e-03
## ASV0385      1.719556e-03  1.799727e-03  1.883403e-03  1.970704e-03
## ASV0295      4.636961e-04  4.955276e-04  5.295780e-04  5.659928e-04
## ASV0072     -3.525054e-03 -3.661612e-03 -3.802207e-03 -3.946862e-03
## ASV0157     -1.992160e-04 -1.889598e-04 -1.767177e-04 -1.622996e-04
## ASV0501      8.148009e-03  8.498573e-03  8.862632e-03  9.240568e-03
## ASV10729    -1.036122e-02 -1.081609e-02 -1.128938e-02 -1.178173e-02
## ASV1470      4.636101e-03  4.798133e-03  4.963502e-03  5.132094e-03
## ASV0050     -8.526799e-03 -8.873657e-03 -9.232332e-03 -9.603055e-03
## ASV0411     -2.078717e-03 -2.173979e-03 -2.273438e-03 -2.377265e-03
## ASV0549      3.282598e-03  3.429030e-03  3.581555e-03  3.740388e-03
## ASV0184      1.044044e-03  1.087776e-03  1.133185e-03  1.180329e-03
## ASV0705      1.988204e-03  2.064946e-03  2.143910e-03  2.225103e-03
## ASV1715      4.452274e-03  4.642000e-03  4.838934e-03  5.043282e-03
## ASV0603      7.374193e-04  7.724997e-04  8.093206e-04  8.479788e-04
## ASV0826      7.378877e-03  7.684740e-03  8.001602e-03  8.329743e-03
## ASV0034     -2.289590e-03 -2.379329e-03 -2.471838e-03 -2.567148e-03
## ASV0838      1.002261e-03  9.993567e-04  9.923245e-04  9.806921e-04
## ASV0614     -2.016137e-03 -2.099495e-03 -2.185834e-03 -2.275230e-03
## ASV0014     -5.379608e-03 -5.603934e-03 -5.836384e-03 -6.077162e-03
## ASV0585      1.299820e-04  1.045969e-04  7.580302e-05  4.332512e-05
## ASV0016     -5.619530e-03 -5.853853e-03 -6.096663e-03 -6.348172e-03
## ASV5394     -4.307038e-03 -4.492854e-03 -4.685901e-03 -4.886397e-03
## ASV0666      8.752428e-03  9.089028e-03  9.435604e-03  9.792244e-03
## ASV2085      1.351066e-03  1.357217e-03  1.359577e-03  1.357743e-03
## ASV0003     -3.826335e-03 -3.985543e-03 -4.150493e-03 -4.321328e-03
## ASV0346      2.075886e-03  2.171824e-03  2.271921e-03  2.376324e-03
## ASV0267      1.396146e-04  1.556331e-04  1.730185e-04  1.918567e-04
## ASV0353      3.237464e-03  3.384299e-03  3.537445e-03  3.697141e-03
## ASV2419      8.131930e-03  8.463645e-03  8.806820e-03  9.161702e-03
## ASV0447      4.764353e-03  4.981085e-03  5.207122e-03  5.442808e-03
## ASV0654      6.670492e-03  6.949414e-03  7.238451e-03  7.537851e-03
## ASV0151      1.082853e-03  1.141406e-03  1.203220e-03  1.268472e-03
## ASV0065     -2.540615e-03 -2.644286e-03 -2.751530e-03 -2.862423e-03
## ASV0527      6.305899e-03  6.567350e-03  6.838176e-03  7.118605e-03
## ASV4055     -1.153314e-03 -1.212796e-03 -1.275546e-03 -1.341759e-03
## ASV0166     -3.027633e-03 -3.143806e-03 -3.263384e-03 -3.386391e-03
## ASV0417     -1.147677e-03 -1.185360e-03 -1.223589e-03 -1.262316e-03
## ASV0078     -1.811714e-03 -1.882052e-03 -1.954464e-03 -2.028958e-03
## ASV0322     -1.729550e-04 -1.668311e-04 -1.591443e-04 -1.497181e-04
## ASV0156     -4.639534e-03 -4.844182e-03 -5.057268e-03 -5.279096e-03
## ASV0648     -1.014286e-02 -1.059366e-02 -1.106316e-02 -1.155204e-02
## ASV0407     -7.963981e-04 -8.343467e-04 -8.741021e-04 -9.157500e-04
## ASV2030     -1.613425e-03 -1.682748e-03 -1.755085e-03 -1.830593e-03
## ASV0300      1.255922e-03  1.314481e-03  1.375655e-03  1.439546e-03
## ASV1150      3.231697e-04  3.406200e-04  3.590023e-04  3.783599e-04
## ASV0958      3.911506e-03  4.097040e-03  4.291272e-03  4.494595e-03
## ASV0216     -3.904914e-03 -4.064904e-03 -4.230714e-03 -4.402529e-03
## ASV0446      6.243622e-03  6.519973e-03  6.807610e-03  7.106911e-03
## ASV0367     -4.019055e-03 -4.192765e-03 -4.373304e-03 -4.560890e-03
## ASV0200     -2.382136e-03 -2.484326e-03 -2.590439e-03 -2.700590e-03
## ASV0334     -1.020475e-03 -1.047632e-03 -1.074683e-03 -1.101562e-03
## ASV1311      1.320213e-03  1.360671e-03  1.401375e-03  1.442227e-03
## ASV0458      1.918903e-03  1.976334e-03  2.034100e-03  2.092083e-03
## ASV1371      4.222911e-04  4.430784e-04  4.648198e-04  4.875468e-04
## ASV0418      4.923804e-03  5.110856e-03  5.303309e-03  5.501204e-03
## ASV0004      7.061067e-04  7.323724e-04  7.593457e-04  7.870273e-04
## ASV1943      1.207206e-02  1.243165e-02  1.279439e-02  1.315977e-02
## ASV1495     -1.501594e-03 -1.595491e-03 -1.695457e-03 -1.801870e-03
## ASV0901     -4.662630e-03 -4.874667e-03 -5.095987e-03 -5.326974e-03
## ASV0628      2.109206e-03  2.181086e-03  2.254227e-03  2.328553e-03
## ASV0400      1.359815e-03  1.411557e-03  1.464705e-03  1.519246e-03
## ASV0116     -1.364648e-03 -1.426201e-03 -1.490397e-03 -1.557340e-03
## ASV0788      1.211538e-02  1.266532e-02  1.323917e-02  1.383788e-02
## ASV0117      9.351074e-04  9.800933e-04  1.027203e-03  1.076528e-03
## ASV3137     -2.574347e-04 -2.673927e-04 -2.776414e-04 -2.881810e-04
## ASV0001      7.498924e-04  7.771560e-04  8.050913e-04  8.336920e-04
## ASV1651      2.175803e-03  2.257823e-03  2.342149e-03  2.428794e-03
## ASV1692      1.004947e-02  1.050237e-02  1.097460e-02  1.146691e-02
## ASV0660      2.995194e-03  3.091524e-03  3.188890e-03  3.287110e-03
## ASV0508      1.446427e-04  1.490073e-04  1.534029e-04  1.578208e-04
## ASV1660     -2.205645e-03 -2.315559e-03 -2.430834e-03 -2.551701e-03
## ASV0233      3.005226e-03  3.134289e-03  3.268363e-03  3.407601e-03
## ASV1343     -5.696551e-03 -5.951829e-03 -6.217934e-03 -6.495280e-03
## ASV0209      2.517230e-03  2.609357e-03  2.703800e-03  2.800538e-03
## ASV0193     -2.972754e-03 -3.083557e-03 -3.197265e-03 -3.313859e-03
## ASV0357      1.486147e-03  1.567265e-03  1.653049e-03  1.743773e-03
## ASV0198      2.358582e-03  2.454220e-03  2.553165e-03  2.655496e-03
## ASV0007      6.440628e-04  6.662082e-04  6.887836e-04  7.117725e-04
## ASV1772     -8.886899e-04 -9.120634e-04 -9.348824e-04 -9.569813e-04
## ASV0009      5.161129e-04  5.327033e-04  5.495065e-04  5.664993e-04
## ASV0006     -7.102633e-04 -7.441132e-04 -7.795412e-04 -8.166150e-04
## ASV0011     -2.329058e-03 -2.431932e-03 -2.539027e-03 -2.650489e-03
## ASV0015      3.888015e-04  4.011564e-04  4.136485e-04  4.262575e-04
## ASV0017      4.402140e-04  4.544430e-04  4.688654e-04  4.834628e-04
## ASV0235     -2.171151e-03 -2.268144e-03 -2.369188e-03 -2.474430e-03
## ASV0382      1.684044e-03  1.757099e-03  1.832862e-03  1.911380e-03
## ASV2357      7.007256e-03  7.316727e-03  7.638970e-03  7.974447e-03
## ASV0567     -1.386964e-03 -1.450811e-03 -1.517590e-03 -1.587438e-03
## ASV0165      1.165374e-03  1.216338e-03  1.269328e-03  1.324407e-03
## ASV0005      1.633060e-03  1.700773e-03  1.770889e-03  1.843465e-03
## ASV0384     -3.956847e-05 -3.165360e-05 -2.261698e-05 -1.235715e-05
## ASV0002      2.919778e-04  3.033384e-04  3.150619e-04  3.271560e-04
## ASV3017      8.167838e-03  8.475332e-03  8.791301e-03  9.115756e-03
## ASV0091     -2.171078e-04 -2.263004e-04 -2.358830e-04 -2.458763e-04
## ASV0186     -3.321519e-03 -3.461082e-03 -3.605727e-03 -3.755576e-03
## ASV0370      1.708764e-03  1.777220e-03  1.847930e-03  1.920935e-03
## ASV0018      2.103555e-03  2.191581e-03  2.282805e-03  2.377305e-03
## ASV1377      2.010882e-02  2.088739e-02  2.168938e-02  2.251502e-02
## ASV0019      2.210578e-03  2.303355e-03  2.399529e-03  2.499186e-03
## ASV0023     -1.445192e-03 -1.510059e-03 -1.577644e-03 -1.648043e-03
## ASV2194      2.376177e-03  2.486996e-03  2.602892e-03  2.724089e-03
## ASV1155      8.436368e-03  8.768718e-03  9.112028e-03  9.466541e-03
## ASV0510     -2.066081e-03 -2.133524e-03 -2.202021e-03 -2.271514e-03
## ASV2371     -5.072939e-03 -5.271411e-03 -5.476204e-03 -5.687427e-03
## ASV0024     -1.790767e-03 -1.870607e-03 -1.953757e-03 -2.040330e-03
## ASV2452      4.798399e-03  4.963548e-03  5.131815e-03  5.303052e-03
## ASV2332     -1.479172e-02 -1.538609e-02 -1.600079e-02 -1.663633e-02
## ASV2591      4.658650e-03  4.892884e-03  5.138271e-03  5.395234e-03
## ASV0521      3.635201e-03  3.797468e-03  3.966534e-03  4.142649e-03
## ASV5542      3.463632e-03  3.615840e-03  3.774105e-03  3.938616e-03
## ASV0336     -5.869460e-04 -6.222470e-04 -6.596783e-04 -6.993573e-04
## ASV10102     6.402068e-03  6.684815e-03  6.979008e-03  7.285016e-03
## ASV16823    -8.766159e-03 -9.087815e-03 -9.418123e-03 -9.757125e-03
## ASV3104      4.533719e-02  4.700001e-02  4.870751e-02  5.045989e-02
## ASV0781      6.873474e-03  7.161215e-03  7.459565e-03  7.768822e-03
## ASV10899     4.812598e-03  5.064981e-03  5.330724e-03  5.610500e-03
## ASV11222    -1.542007e-02 -1.598563e-02 -1.656641e-02 -1.716246e-02
## ASV11327    -1.383815e-02 -1.434547e-02 -1.486641e-02 -1.540105e-02
## ASV12458    -1.540593e-02 -1.597048e-02 -1.655017e-02 -1.714508e-02
## ASV1636      9.120779e-03  9.480257e-03  9.851189e-03  1.023376e-02
## ASV1890     -6.684432e-03 -6.903854e-03 -7.127255e-03 -7.354513e-03
## ASV2898      1.225662e-02  1.274169e-02  1.324236e-02  1.375889e-02
## ASV8328      2.708356e-03  2.900772e-03  3.106507e-03  3.326390e-03
## ASV0709     -1.394568e-02 -1.451466e-02 -1.510312e-02 -1.571147e-02
## ASV0856      1.252833e-02  1.310384e-02  1.370445e-02  1.433111e-02
## ASV0909      4.375612e-03  4.624373e-03  4.887519e-03  5.165828e-03
## ASV0937     -8.658949e-03 -9.047673e-03 -9.453201e-03 -9.876225e-03
## ASV11390    -2.198134e-02 -2.278676e-02 -2.361379e-02 -2.446254e-02
## ASV11966     6.324738e-03  6.625833e-03  6.940679e-03  7.269822e-03
## ASV12990     3.959395e-03  4.110519e-03  4.265989e-03  4.425839e-03
## ASV14797     5.788483e-03  6.005676e-03  6.228935e-03  6.458299e-03
## ASV14904    -3.154072e-02 -3.269644e-02 -3.388318e-02 -3.510111e-02
## ASV15304     4.175780e-03  4.386616e-03  4.607835e-03  4.839884e-03
## ASV16696    -1.089485e-02 -1.129400e-02 -1.170386e-02 -1.212448e-02
## ASV1690      2.129377e-02  2.226557e-02  2.327843e-02  2.433370e-02
## ASV2029      1.366190e-02  1.421902e-02  1.479555e-02  1.539194e-02
## ASV2834      1.786442e-02  1.864072e-02  1.944759e-02  2.028596e-02
## ASV4003      1.586956e-02  1.664194e-02  1.745200e-02  1.830157e-02
## ASV4064      8.565336e-03  8.942742e-03  9.335371e-03  9.743719e-03
## ASV4294      5.809996e-03  6.108045e-03  6.421491e-03  6.751096e-03
## ASV4609      4.581871e-03  4.766124e-03  4.956673e-03  5.153679e-03
## ASV6283     -1.018926e-02 -1.056292e-02 -1.094665e-02 -1.134050e-02
## ASV6491     -1.459769e-02 -1.513277e-02 -1.568226e-02 -1.624623e-02
## ASV7453      8.456404e-03  8.863099e-03  9.288657e-03  9.733845e-03
## ASV7959      3.476423e-03  3.670007e-03  3.874447e-03  4.090308e-03
## ASV8219      1.261416e-01  1.307659e-01  1.355149e-01  1.403892e-01
## ASV8547     -1.306196e-02 -1.354059e-02 -1.403212e-02 -1.453660e-02
## ASV9319      6.542215e-03  6.841618e-03  7.154125e-03  7.480262e-03
## ASV9382     -2.555221e-02 -2.648845e-02 -2.744990e-02 -2.843671e-02
## ASV11516    -1.705901e-02 -1.768378e-02 -1.832536e-02 -1.898383e-02
## ASV14377    -1.231189e-02 -1.276260e-02 -1.322542e-02 -1.370042e-02
## ASV1867      1.073053e-02  1.120564e-02  1.170028e-02  1.221513e-02
## ASV1895      4.675702e-03  4.833755e-03  4.994323e-03  5.157200e-03
## ASV3168      6.112907e-03  6.338202e-03  6.569183e-03  6.805800e-03
## ASV4449      3.606262e-02  3.758293e-02  3.916105e-02  4.079881e-02
## ASV6596      8.462688e-03  8.883596e-03  9.325528e-03  9.789501e-03
## ASV7492     -5.055915e-04 -4.712424e-04 -4.314842e-04 -3.858872e-04
## ASV9854     -2.583308e-03 -2.675427e-03 -2.769920e-03 -2.866796e-03
## ASV6296      2.064999e-01  2.140568e-01  2.218168e-01  2.297809e-01
## ASV4201      2.017623e-03  2.164724e-03  2.322213e-03  2.490751e-03
## ASV0552      7.374151e-03  7.696971e-03  8.032707e-03  8.381774e-03
## ASV3671     -4.725587e-03 -4.924403e-03 -5.131139e-03 -5.346118e-03
## ASV3529     -5.780190e-04 -5.615756e-04 -5.418025e-04 -5.184628e-04
## ASV1060      2.062156e-03  2.160126e-03  2.262767e-03  2.370304e-03
## ASV0239     -2.317893e-03 -2.398087e-03 -2.479960e-03 -2.563474e-03
## ASV5711     -1.134138e-02 -1.179807e-02 -1.227051e-02 -1.275908e-02
## ASV4152     -1.671052e-02 -1.742633e-02 -1.816990e-02 -1.894207e-02
## ASV1461      7.557977e-03  7.824081e-03  8.096050e-03  8.373768e-03
## ASV2877      3.989943e-03  4.134434e-03  4.282381e-03  4.433735e-03
## ASV0012      7.504283e-04  7.822691e-04  8.153245e-04  8.496320e-04
## ASV9823      7.463584e-04  7.550531e-04  7.620669e-04  7.671797e-04
## ASV0008      7.930152e-04  8.262033e-04  8.606268e-04  8.963224e-04
## ASV7832     -9.947273e-03 -1.038270e-02 -1.083597e-02 -1.130772e-02
## ASV1915     -1.185062e-03 -1.233525e-03 -1.283927e-03 -1.336361e-03
## ASV0055     -9.986074e-04 -1.050053e-03 -1.104180e-03 -1.161121e-03
## ASV0032      3.169059e-04  3.249390e-04  3.328717e-04  3.406753e-04
## ASV2977     -1.378134e-02 -1.436581e-02 -1.497242e-02 -1.560183e-02
## ASV0466      1.002249e-02  1.037696e-02  1.073933e-02  1.110943e-02
## ASV3866      7.885343e-03  8.241130e-03  8.612193e-03  8.999129e-03
## ASV0040      2.775465e-03  2.895760e-03  3.020814e-03  3.150781e-03
## ASV0496     -1.087746e-03 -1.163136e-03 -1.243678e-03 -1.329683e-03
## ASV0052      2.334304e-03  2.435702e-03  2.541126e-03  2.650708e-03
## ASV3828     -7.280154e-03 -7.544180e-03 -7.815093e-03 -8.092911e-03
## ASV1930      3.869685e-03  4.016711e-03  4.167788e-03  4.322909e-03
## ASV2126      6.833347e-03  7.112492e-03  7.401419e-03  7.700367e-03
## ASV0793      8.862902e-03  9.257221e-03  9.667884e-03  1.009547e-02
## ASV0299     -2.068526e-04 -2.196569e-04 -2.334749e-04 -2.484032e-04
## ASV0208      6.285267e-03  6.558219e-03  6.842091e-03  7.137259e-03
## ASV0511     -2.254317e-03 -2.330177e-03 -2.407399e-03 -2.485929e-03
## ASV1123     -6.959092e-03 -7.205311e-03 -7.457226e-03 -7.714769e-03
## ASV0099      2.930724e-04  3.101400e-04  3.282915e-04  3.475995e-04
## ASV0752     -4.711438e-03 -4.931077e-03 -5.160584e-03 -5.400363e-03
## ASV0883      6.416659e-03  6.712378e-03  7.021035e-03  7.343118e-03
## ASV0683      8.273810e-03  8.648757e-03  9.039784e-03  9.447497e-03
## ASV4117     -1.279342e-02 -1.335145e-02 -1.393219e-02 -1.453645e-02
## ASV2172      6.237583e-04  6.366499e-04  6.488908e-04  6.603706e-04
## ASV0330     -2.419090e-03 -2.526183e-03 -2.637721e-03 -2.753869e-03
## ASV0728      1.156177e-02  1.204553e-02  1.254691e-02  1.306637e-02
## ASV0499      3.242484e-03  3.391173e-03  3.546401e-03  3.708430e-03
## ASV0120     -5.144585e-03 -5.360725e-03 -5.584759e-03 -5.816884e-03
## ASV1446      3.195104e-03  3.280138e-03  3.364478e-03  3.447819e-03
## ASV17171    -9.947966e-03 -1.037150e-02 -1.081159e-02 -1.126881e-02
## ASV0533      8.323301e-04  8.736621e-04  9.170339e-04  9.625393e-04
## ASV2495     -2.902470e-03 -3.058389e-03 -3.223004e-03 -3.396790e-03
## ASV5582      3.913955e-03  4.033941e-03  4.154950e-03  4.276772e-03
## ASV1488      1.646011e-03  1.707197e-03  1.769888e-03  1.834052e-03
## ASV0682      2.380458e-03  2.490572e-03  2.605570e-03  2.725644e-03
## ASV0068     -3.925531e-03 -4.092409e-03 -4.265526e-03 -4.445041e-03
## ASV1987     -1.043975e-02 -1.092958e-02 -1.144161e-02 -1.197674e-02
## ASV0035     -1.019105e-03 -1.083728e-03 -1.152692e-03 -1.226290e-03
## ASV7192     -5.844914e-03 -6.079250e-03 -6.321415e-03 -6.571562e-03
## ASV0873     -5.413914e-03 -5.938812e-03 -6.504180e-03 -7.112415e-03
## ASV4749     -1.073114e-03 -1.178134e-03 -1.291890e-03 -1.414988e-03
## ASV2174      3.644367e-03  3.760634e-03  3.878246e-03  3.997014e-03
## ASV1476     -4.584435e-03 -4.798626e-03 -5.022674e-03 -5.257013e-03
## ASV0740     -1.291937e-02 -1.351352e-02 -1.413400e-02 -1.478188e-02
## ASV0170     -2.418491e-03 -2.522519e-03 -2.630611e-03 -2.742899e-03
## ASV2466     -1.106041e-02 -1.154012e-02 -1.203907e-02 -1.255794e-02
## ASV1709      3.843655e-03  4.000091e-03  4.162537e-03  4.331251e-03
## ASV6170     -1.774942e-02 -1.854583e-02 -1.937595e-02 -2.024107e-02
## ASV3673      8.856104e-03  9.262546e-03  9.686871e-03  1.012979e-02
## ASV1745     -2.427225e-03 -2.547290e-03 -2.673284e-03 -2.805484e-03
##                                                                    
## (Intercept)  6.914261e-02  7.202705e-02  7.501512e-02  7.810926e-02
## ASV1236      1.280191e-02  1.328962e-02  1.379187e-02  1.430885e-02
## ASV0421      2.093963e-03  2.213113e-03  2.338907e-03  2.471659e-03
## ASV0691     -8.749426e-03 -9.010165e-03 -9.273351e-03 -9.538666e-03
## ASV0899      1.112328e-02  1.154390e-02  1.197626e-02  1.242039e-02
## ASV1004      2.572166e-02  2.670254e-02  2.771225e-02  2.875111e-02
## ASV1041     -1.039789e-02 -1.077786e-02 -1.116700e-02 -1.156518e-02
## ASV1058      1.602485e-02  1.663578e-02  1.726486e-02  1.791231e-02
## ASV12542     5.977162e-03  6.191320e-03  6.410895e-03  6.635904e-03
## ASV1294      1.495389e-02  1.552655e-02  1.611644e-02  1.672382e-02
## ASV13113     5.841039e-03  6.119981e-03  6.412071e-03  6.717900e-03
## ASV1318      1.487245e-02  1.543843e-02  1.602101e-02  1.662038e-02
## ASV2269     -2.553724e-02 -2.649106e-02 -2.747081e-02 -2.847652e-02
## ASV2542      1.384086e-02  1.445211e-02  1.508860e-02  1.575126e-02
## ASV2660     -1.007493e-02 -1.044695e-02 -1.082889e-02 -1.122077e-02
## ASV2737      3.261711e-03  3.370205e-03  3.480908e-03  3.593803e-03
## ASV2840      1.283443e-02  1.326946e-02  1.371278e-02  1.416411e-02
## ASV3053      6.755561e-02  6.999143e-02  7.248960e-02  7.505028e-02
## ASV3077      4.350500e-03  4.510687e-03  4.675333e-03  4.844489e-03
## ASV3134      9.082683e-03  9.502871e-03  9.941931e-03  1.040066e-02
## ASV3140      1.147890e-02  1.195856e-02  1.245566e-02  1.297064e-02
## ASV3579      4.686486e-03  4.920755e-03  5.166641e-03  5.424671e-03
## ASV6119     -6.986090e-03 -7.246967e-03 -7.514942e-03 -7.790024e-03
## ASV7557     -1.418902e-02 -1.471854e-02 -1.526245e-02 -1.582075e-02
## ASV8422      3.467346e-03  3.594222e-03  3.724577e-03  3.858449e-03
## ASV1086     -4.663572e-04 -4.795897e-04 -4.929930e-04 -5.065703e-04
## ASV1310      6.835513e-03  7.093592e-03  7.359025e-03  7.631863e-03
## ASV15750    -8.228111e-04 -8.466990e-04 -8.706269e-04 -8.945343e-04
## ASV16905    -2.917772e-03 -3.026671e-03 -3.138530e-03 -3.253352e-03
## ASV2033      1.409506e-02  1.472538e-02  1.538181e-02  1.606524e-02
## ASV2089      6.163368e-03  6.393989e-03  6.630916e-03  6.874159e-03
## ASV2127      2.012127e-02  2.088468e-02  2.167036e-02  2.247856e-02
## ASV2725      1.566611e-02  1.623412e-02  1.681662e-02  1.741358e-02
## ASV2804     -6.039153e-03 -6.264566e-03 -6.496113e-03 -6.733802e-03
## ASV3075      1.412846e-02  1.472037e-02  1.533491e-02  1.597284e-02
## ASV3327      2.025016e-02  2.113091e-02  2.204651e-02  2.299805e-02
## ASV3342      1.722648e-02  1.796723e-02  1.873691e-02  1.953643e-02
## ASV3532     -1.865382e-02 -1.943745e-02 -2.025060e-02 -2.109420e-02
## ASV3600      8.736719e-03  9.107034e-03  9.491432e-03  9.890340e-03
## ASV4013      1.563586e-02  1.625750e-02  1.689944e-02  1.756203e-02
## ASV4136      1.585684e-02  1.644302e-02  1.704544e-02  1.766425e-02
## ASV4195      6.161367e-02  6.391232e-02  6.627346e-02  6.869718e-02
## ASV4407     -2.379252e-02 -2.467961e-02 -2.559077e-02 -2.652604e-02
## ASV4717      3.752656e-03  3.871904e-03  3.993118e-03  4.116242e-03
## ASV6794      9.491673e-03  9.829094e-03  1.017508e-02  1.052968e-02
## ASV8324     -1.220828e-02 -1.266343e-02 -1.313093e-02 -1.361079e-02
## ASV8981      1.729233e-06  2.162950e-05  4.384225e-05  6.854725e-05
## ASV9859      5.454781e-03  5.739883e-03  6.040326e-03  6.356930e-03
## ASV0936      1.296834e-02  1.352131e-02  1.409505e-02  1.469012e-02
## ASV12683    -9.516637e-05 -1.026906e-04 -1.106092e-04 -1.189216e-04
## ASV1293      7.906744e-03  8.201858e-03  8.505145e-03  8.816648e-03
## ASV13055     3.522339e-05  5.092138e-05  6.831408e-05  8.752750e-05
## ASV17063    -6.323194e-03 -6.558569e-03 -6.800314e-03 -7.048440e-03
## ASV2228      5.153865e-03  5.345594e-03  5.542504e-03  5.744601e-03
## ASV2769      1.131628e-03  1.193133e-03  1.257851e-03  1.325919e-03
## ASV2803      5.266432e-03  5.445322e-03  5.627911e-03  5.814139e-03
## ASV2896      5.020687e-03  5.246028e-03  5.481172e-03  5.726536e-03
## ASV3062      6.509511e-03  6.823452e-03  7.152111e-03  7.496102e-03
## ASV3107      9.168791e-03  9.566576e-03  9.980309e-03  1.041054e-02
## ASV3265      1.125198e-02  1.166791e-02  1.209500e-02  1.253330e-02
## ASV3666      6.597827e-05  6.519340e-05  6.405686e-05  6.253148e-05
## ASV4497      3.964193e-03  4.117059e-03  4.274577e-03  4.436811e-03
## ASV6914     -7.906943e-04 -8.331669e-04 -8.778821e-04 -9.249421e-04
## ASV0576     -1.254806e-02 -1.296185e-02 -1.338310e-02 -1.381157e-02
## ASV0673      1.547418e-02  1.608235e-02  1.670985e-02  1.735700e-02
## ASV0772      7.312641e-03  7.609425e-03  7.916575e-03  8.234354e-03
## ASV0862      1.513267e-03  1.620767e-03  1.735301e-03  1.857234e-03
## ASV0898      6.192953e-03  6.472379e-03  6.763429e-03  7.066483e-03
## ASV0910      6.933361e-03  7.236958e-03  7.552845e-03  7.881446e-03
## ASV0964     -4.847167e-03 -5.012503e-03 -5.181189e-03 -5.353145e-03
## ASV10059     5.225654e-03  5.471034e-03  5.727549e-03  5.995654e-03
## ASV10263    -9.659143e-03 -1.002040e-02 -1.039159e-02 -1.077277e-02
## ASV1088      1.220682e-02  1.273600e-02  1.328663e-02  1.385950e-02
## ASV1101      1.373324e-02  1.424271e-02  1.476594e-02  1.530295e-02
## ASV1183      3.915601e-03  4.079242e-03  4.248939e-03  4.424869e-03
## ASV11956     3.255861e-03  3.362739e-03  3.471605e-03  3.582417e-03
## ASV12774    -4.924637e-05 -6.675600e-05 -8.604752e-05 -1.072416e-04
## ASV1321      1.814860e-02  1.895642e-02  1.979775e-02  2.067376e-02
## ASV13793    -6.657690e-03 -6.906540e-03 -7.162225e-03 -7.424765e-03
## ASV14482     3.575328e-04  3.683586e-04  3.794470e-04  3.908150e-04
## ASV15483     3.016678e-03  3.146764e-03  3.281883e-03  3.422182e-03
## ASV2062      1.323489e-02  1.376176e-02  1.430617e-02  1.486850e-02
## ASV2132      1.142528e-02  1.191576e-02  1.242517e-02  1.295408e-02
## ASV2413      9.980099e-03  1.036286e-02  1.075728e-02  1.116356e-02
## ASV2490      2.939584e-02  3.044244e-02  3.151446e-02  3.261177e-02
## ASV2594      4.126906e-03  4.304777e-03  4.489908e-03  4.682585e-03
## ASV2822     -1.759256e-02 -1.825165e-02 -1.892901e-02 -1.962471e-02
## ASV2863      1.846337e-02  1.914585e-02  1.984720e-02  2.056756e-02
## ASV2910      6.836066e-03  7.092522e-03  7.356257e-03  7.627334e-03
## ASV2980      7.942893e-03  8.259731e-03  8.587045e-03  8.925039e-03
## ASV3307      1.398356e-02  1.450672e-02  1.504432e-02  1.559640e-02
## ASV3474      1.056944e-02  1.104944e-02  1.155000e-02  1.207189e-02
## ASV3502      1.033674e-02  1.076474e-02  1.120826e-02  1.166774e-02
## ASV4236      1.361978e-02  1.408996e-02  1.457009e-02  1.506000e-02
## ASV4842     -1.687517e-03 -1.756286e-03 -1.827006e-03 -1.899644e-03
## ASV4894     -6.667034e-03 -6.916843e-03 -7.173584e-03 -7.437289e-03
## ASV5290      5.752906e-03  5.996810e-03  6.249851e-03  6.512279e-03
## ASV5501      3.482983e-03  3.631922e-03  3.786939e-03  3.948287e-03
## ASV5795      3.891898e-03  4.058669e-03  4.231843e-03  4.411607e-03
## ASV5987     -1.863346e-02 -1.933243e-02 -2.005088e-02 -2.078892e-02
## ASV6267     -2.098504e-02 -2.177174e-02 -2.258032e-02 -2.341090e-02
## ASV6862      8.174492e-03  8.468766e-03  8.770591e-03  9.079991e-03
## ASV7145      3.536982e-03  3.662770e-03  3.791995e-03  3.924720e-03
## ASV7673     -6.666821e-03 -6.916705e-03 -7.173539e-03 -7.437357e-03
## ASV7789      4.164796e-03  4.376616e-03  4.599253e-03  4.833228e-03
## ASV7809      5.363149e-04  5.754956e-04  6.173148e-04  6.619148e-04
## ASV8002     -8.421421e-03 -8.737289e-03 -9.061976e-03 -9.395529e-03
## ASV8205      3.816929e-03  3.979108e-03  4.147510e-03  4.322330e-03
## ASV9155     -2.051199e-03 -2.122430e-03 -2.195165e-03 -2.269369e-03
## ASV9221      1.436876e-03  1.527440e-03  1.623720e-03  1.726042e-03
## ASV9311     -1.350859e-02 -1.401542e-02 -1.453644e-02 -1.507173e-02
## ASV9557     -9.227212e-03 -9.573195e-03 -9.928843e-03 -1.029421e-02
## ASV9936     -1.859807e-02 -1.929499e-02 -2.001134e-02 -2.074723e-02
## ASV1445      1.222683e-02  1.274360e-02  1.327976e-02  1.383585e-02
## ASV4232      5.059057e-03  5.301794e-03  5.556292e-03  5.823130e-03
## ASV6479      2.330108e-03  2.469344e-03  2.617018e-03  2.773608e-03
## ASV0142     -7.933598e-03 -8.226992e-03 -8.528400e-03 -8.837871e-03
## ASV0378      4.270275e-03  4.469844e-03  4.678283e-03  4.895926e-03
## ASV1122      1.198642e-02  1.250245e-02  1.303861e-02  1.359554e-02
## ASV0123     -6.979826e-03 -7.236269e-03 -7.499571e-03 -7.769759e-03
## ASV2064      3.258133e-03  3.356532e-03  3.455567e-03  3.555035e-03
## ASV4459     -3.910378e-04 -3.999418e-04 -4.088252e-04 -4.176949e-04
## ASV0448      3.421876e-03  3.582304e-03  3.749936e-03  3.925058e-03
## ASV0397      6.765244e-03  7.039757e-03  7.323686e-03  7.617234e-03
## ASV0485      7.688662e-03  7.991291e-03  8.303704e-03  8.626084e-03
## ASV1566      1.152095e-02  1.198470e-02  1.246409e-02  1.295943e-02
## ASV1365      1.003189e-02  1.044547e-02  1.087348e-02  1.131622e-02
## ASV1065      1.423808e-02  1.482711e-02  1.543729e-02  1.606916e-02
## ASV0722     -8.102530e-04 -8.487442e-04 -8.891258e-04 -9.314979e-04
## ASV12660    -7.525171e-03 -7.800188e-03 -8.082515e-03 -8.372180e-03
## ASV0223      2.147006e-03  2.233315e-03  2.322605e-03  2.414956e-03
## ASV0229      3.474247e-03  3.625620e-03  3.783096e-03  3.946889e-03
## ASV0877      1.118067e-03  1.143739e-03  1.168320e-03  1.191584e-03
## ASV0983      7.534077e-03  7.823583e-03  8.121765e-03  8.428721e-03
## ASV0626      1.353577e-03  1.437744e-03  1.526883e-03  1.621230e-03
## ASV4146      3.143203e-04  3.194610e-04  3.237256e-04  3.269543e-04
## ASV4175     -9.960109e-03 -1.038491e-02 -1.082591e-02 -1.128357e-02
## ASV2082     -5.583103e-03 -5.889618e-03 -6.213431e-03 -6.555483e-03
## ASV2272      4.721396e-03  4.923059e-03  5.132615e-03  5.350329e-03
## ASV2245     -7.180599e-03 -7.490514e-03 -7.812491e-03 -8.146893e-03
## ASV0590     -5.535981e-03 -5.850731e-03 -6.183645e-03 -6.535706e-03
## ASV0217      1.103256e-03  1.192023e-03  1.287151e-03  1.389010e-03
## ASV0416      4.379986e-03  4.507704e-03  4.635947e-03  4.764447e-03
## ASV1056      7.126080e-03  7.443773e-03  7.774508e-03  8.118715e-03
## ASV7777     -9.625337e-03 -1.003430e-02 -1.045908e-02 -1.090021e-02
## ASV0455      1.691582e-03  1.760576e-03  1.831916e-03  1.905646e-03
## ASV0604      4.794933e-03  5.014524e-03  5.243556e-03  5.482372e-03
## ASV6100     -6.795326e-03 -7.094004e-03 -7.405017e-03 -7.728830e-03
## ASV11359    -1.420339e-02 -1.479907e-02 -1.541656e-02 -1.605641e-02
## ASV6604      2.092381e-03  2.187413e-03  2.286482e-03  2.389729e-03
## ASV5004     -4.999226e-03 -5.207253e-03 -5.422979e-03 -5.646633e-03
## ASV1483     -2.118811e-03 -2.204468e-03 -2.293046e-03 -2.384608e-03
## ASV9773     -6.486495e-03 -6.765441e-03 -7.055358e-03 -7.356614e-03
## ASV4059      5.852963e-04  6.433991e-04  7.061497e-04  7.738371e-04
## ASV1193      7.570178e-03  7.879141e-03  8.198912e-03  8.529751e-03
## ASV4610     -4.714098e-04 -4.513592e-04 -4.280146e-04 -4.011652e-04
## ASV0742     -8.866503e-05 -5.629985e-05 -2.025144e-05  1.971742e-05
## ASV1502     -7.520326e-04 -8.067903e-04 -8.652401e-04 -9.275830e-04
## ASV0195     -5.645980e-05 -7.240085e-05 -8.988088e-05 -1.089991e-04
## ASV1213      4.714884e-03  4.871204e-03  5.030295e-03  5.192043e-03
## ASV1648     -6.090037e-03 -6.357575e-03 -6.636233e-03 -6.926443e-03
## ASV6984     -5.714958e-03 -5.967343e-03 -6.230352e-03 -6.504411e-03
## ASV0396     -5.445389e-05 -4.349254e-05 -3.139367e-05 -1.811378e-05
## ASV4297      7.083869e-03  7.334226e-03  7.590388e-03  7.852293e-03
## ASV2622      1.146487e-02  1.190152e-02  1.235112e-02  1.281383e-02
## ASV3512      5.603612e-03  5.891295e-03  6.194033e-03  6.512596e-03
## ASV2411      8.825329e-03  9.224758e-03  9.641236e-03  1.007539e-02
## ASV2291     -4.898199e-03 -5.180142e-03 -5.478336e-03 -5.793627e-03
## ASV0807      1.114214e-02  1.159461e-02  1.206245e-02  1.254598e-02
## ASV1292      2.265114e-03  2.333033e-03  2.401553e-03  2.470580e-03
## ASV1035      9.631090e-03  9.992161e-03  1.036375e-02  1.074600e-02
## ASV0070      3.722152e-04  4.048520e-04  4.400374e-04  4.779389e-04
## ASV0255      8.019142e-04  8.234023e-04  8.445938e-04  8.653815e-04
## ASV0057     -2.483358e-03 -2.564926e-03 -2.647800e-03 -2.731897e-03
## ASV0077     -4.242856e-04 -4.315232e-04 -4.382731e-04 -4.444785e-04
## ASV0625      5.425592e-03  5.619860e-03  5.818862e-03  6.022571e-03
## ASV2464      3.680539e-02  3.812826e-02  3.948492e-02  4.087541e-02
## ASV1315      1.160387e-02  1.213477e-02  1.268872e-02  1.326659e-02
## ASV2673      9.984871e-03  1.044371e-02  1.092264e-02  1.142246e-02
## ASV2161      4.208863e-03  4.402390e-03  4.604516e-03  4.815599e-03
## ASV0337     -2.296629e-03 -2.395374e-03 -2.497961e-03 -2.604513e-03
## ASV7680     -1.509918e-02 -1.575563e-02 -1.643824e-02 -1.714787e-02
## ASV0611      8.472785e-03  8.844347e-03  9.231062e-03  9.633468e-03
## ASV3118     -9.230111e-03 -9.657951e-03 -1.010472e-02 -1.057116e-02
## ASV1284      1.154461e-03  1.090244e-03  1.014771e-03  9.270703e-04
## ASV0889      5.916372e-03  6.148718e-03  6.388672e-03  6.636408e-03
## ASV4649     -3.110195e-03 -3.240755e-03 -3.376206e-03 -3.516694e-03
## ASV1108     -7.106920e-03 -7.448643e-03 -7.806491e-03 -8.181168e-03
## ASV0738      4.350218e-03  4.582336e-03  4.827035e-03  5.084968e-03
## ASV0473     -1.013899e-03 -1.071732e-03 -1.132614e-03 -1.196659e-03
## ASV0598     -2.389472e-03 -2.525841e-03 -2.670237e-03 -2.823115e-03
## ASV0429      4.211839e-03  4.364070e-03  4.519967e-03  4.679484e-03
## ASV1549      9.240766e-03  9.666946e-03  1.011190e-02  1.057635e-02
## ASV1203      6.455697e-03  6.708298e-03  6.968818e-03  7.237372e-03
## ASV4532      1.741182e-04  1.760687e-04  1.778580e-04  1.794877e-04
## ASV0274      1.352331e-03  1.417868e-03  1.486329e-03  1.557805e-03
## ASV0163     -4.695260e-03 -4.863713e-03 -5.036499e-03 -5.213643e-03
## ASV1298      4.307089e-04  4.434408e-04  4.566005e-04  4.702458e-04
## ASV9424     -1.185279e-02 -1.237874e-02 -1.292671e-02 -1.349755e-02
## ASV0412      1.108005e-02  1.150794e-02  1.194895e-02  1.240326e-02
## ASV0284      1.887379e-03  1.933761e-03  1.979326e-03  2.023870e-03
## ASV0620     -2.965117e-03 -3.121752e-03 -3.286643e-03 -3.460188e-03
## ASV0153     -1.232936e-02 -1.289545e-02 -1.348615e-02 -1.410238e-02
## ASV0498      4.133955e-03  4.310100e-03  4.492693e-03  4.681870e-03
## ASV0097      2.425888e-03  2.537817e-03  2.654688e-03  2.776693e-03
## ASV0104     -1.546263e-02 -1.608180e-02 -1.672137e-02 -1.738172e-02
## ASV1282      4.947656e-03  5.121036e-03  5.297901e-03  5.478101e-03
## ASV3883     -5.011566e-03 -5.257314e-03 -5.514682e-03 -5.784139e-03
## ASV0801      2.212879e-03  2.309002e-03  2.409001e-03  2.513020e-03
## ASV1611     -1.080383e-02 -1.129177e-02 -1.180056e-02 -1.233101e-02
## ASV0227     -2.412708e-03 -2.546146e-03 -2.686944e-03 -2.835469e-03
## ASV0833      3.523350e-03  3.673237e-03  3.828766e-03  3.990093e-03
## ASV0718      1.568864e-02  1.635547e-02  1.704772e-02  1.776613e-02
## ASV1139      1.256009e-03  1.264671e-03  1.270201e-03  1.272264e-03
## ASV0766     -2.500966e-03 -2.623780e-03 -2.752395e-03 -2.887045e-03
## ASV2091      1.140355e-02  1.181122e-02  1.222862e-02  1.265563e-02
## ASV1238     -1.211047e-02 -1.265600e-02 -1.322537e-02 -1.381961e-02
## ASV9193     -1.789020e-03 -1.905531e-03 -2.029813e-03 -2.162359e-03
## ASV0290      1.234242e-03  1.264555e-03  1.294665e-03  1.324518e-03
## ASV0231      4.347247e-03  4.513415e-03  4.684427e-03  4.860314e-03
## ASV0185      3.313888e-03  3.489643e-03  3.674861e-03  3.870029e-03
## ASV2330      4.631755e-03  4.789016e-03  4.949453e-03  5.113001e-03
## ASV3119     -2.957798e-03 -3.112165e-03 -3.274639e-03 -3.445620e-03
## ASV2368     -6.464173e-03 -6.769261e-03 -7.088676e-03 -7.423083e-03
## ASV0122     -2.761648e-03 -2.871294e-03 -2.984544e-03 -3.101467e-03
## ASV1044      7.793553e-03  8.146297e-03  8.514219e-03  8.897905e-03
## ASV0160     -2.715012e-03 -2.808766e-03 -2.904603e-03 -3.002506e-03
## ASV0326      8.235510e-04  8.579372e-04  8.935014e-04  9.302584e-04
## ASV1388      1.440248e-02  1.497647e-02  1.556923e-02  1.618110e-02
## ASV0792      1.021453e-02  1.059450e-02  1.098483e-02  1.138553e-02
## ASV0036     -3.696300e-03 -3.865325e-03 -4.041578e-03 -4.225311e-03
## ASV2125      1.042764e-02  1.085089e-02  1.128855e-02  1.174092e-02
## ASV1075     -1.691449e-04 -1.775427e-04 -1.864504e-04 -1.959092e-04
## ASV0390      6.144571e-03  6.431095e-03  6.730706e-03  7.043977e-03
## ASV3790     -8.270151e-03 -8.629215e-03 -9.002580e-03 -9.390723e-03
## ASV1535     -2.776572e-03 -2.919102e-03 -3.068905e-03 -3.226316e-03
## ASV0263      9.861239e-03  1.027364e-02  1.070122e-02  1.114439e-02
## ASV0675      1.548158e-02  1.616824e-02  1.688327e-02  1.762769e-02
## ASV3348      1.372639e-03  1.439694e-03  1.509920e-03  1.583445e-03
## ASV0058     -4.233203e-03 -4.400257e-03 -4.572626e-03 -4.750390e-03
## ASV4142      5.659594e-03  5.866368e-03  6.078470e-03  6.295900e-03
## ASV0059     -3.362605e-03 -3.492442e-03 -3.626176e-03 -3.763848e-03
## ASV0013     -6.266861e-03 -6.526983e-03 -6.796494e-03 -7.075634e-03
## ASV0033     -3.194574e-03 -3.339837e-03 -3.491276e-03 -3.649108e-03
## ASV4354     -3.737596e-03 -3.897415e-03 -4.063582e-03 -4.236326e-03
## ASV0022     -2.695148e-03 -2.817753e-03 -2.945600e-03 -3.078876e-03
## ASV0134     -2.730094e-03 -2.864099e-03 -3.004650e-03 -3.152056e-03
## ASV0415      5.210216e-04  5.494051e-04  5.791947e-04  6.104377e-04
## ASV10103    -1.464087e-02 -1.529094e-02 -1.596794e-02 -1.667282e-02
## ASV1613      9.679959e-03  1.003805e-02  1.040551e-02  1.078229e-02
## ASV0135     -1.157052e-03 -1.194593e-03 -1.232689e-03 -1.271299e-03
## ASV0469     -1.291613e-02 -1.342565e-02 -1.395193e-02 -1.449534e-02
## ASV0471      8.133053e-03  8.468864e-03  8.816764e-03  9.177080e-03
## ASV0451     -1.847360e-03 -1.953706e-03 -2.066155e-03 -2.185021e-03
## ASV0747      4.736385e-03  4.937403e-03  5.145940e-03  5.362196e-03
## ASV1314     -5.125326e-03 -5.366710e-03 -5.619281e-03 -5.883536e-03
## ASV0425     -1.531561e-02 -1.587693e-02 -1.645306e-02 -1.704403e-02
## ASV0559     -4.099278e-03 -4.272157e-03 -4.451914e-03 -4.638827e-03
## ASV0148     -5.699355e-04 -5.716823e-04 -5.717045e-04 -5.698178e-04
## ASV0129      1.647546e-03  1.757844e-03  1.875567e-03  2.001178e-03
## ASV1072      8.617952e-04  8.826211e-04  9.029461e-04  9.226564e-04
## ASV2390      7.498841e-03  7.748848e-03  8.002965e-03  8.260928e-03
## ASV0548      5.556036e-03  5.782314e-03  6.016376e-03  6.258385e-03
## ASV0168     -2.760421e-03 -2.867930e-03 -2.978823e-03 -3.093155e-03
## ASV0066     -3.145801e-03 -3.269467e-03 -3.396979e-03 -3.528380e-03
## ASV0468     -1.746123e-03 -1.820439e-03 -1.897642e-03 -1.977827e-03
## ASV0172     -7.550244e-04 -7.731576e-04 -7.908858e-04 -8.081180e-04
## ASV0236      6.721004e-04  7.503840e-04  8.354081e-04  9.276256e-04
## ASV0250      5.375106e-03  5.646774e-03  5.932300e-03  6.232368e-03
## ASV0338      2.323938e-03  2.427020e-03  2.534089e-03  2.645237e-03
## ASV0450     -5.988022e-04 -6.351833e-04 -6.738158e-04 -7.148319e-04
## ASV0377      3.914291e-03  4.067614e-03  4.225696e-03  4.388592e-03
## ASV1022     -1.211178e-04 -1.220182e-04 -1.224926e-04 -1.224791e-04
## ASV6174     -1.945510e-04 -2.095754e-04 -2.257384e-04 -2.431131e-04
## ASV0786     -9.023419e-04 -9.582605e-04 -1.017480e-03 -1.080158e-03
## ASV0053     -4.434625e-03 -4.620772e-03 -4.813776e-03 -5.013817e-03
## ASV0697     -2.503617e-03 -2.598459e-03 -2.696133e-03 -2.796683e-03
## ASV0785      5.434045e-03  5.648115e-03  5.869022e-03  6.096877e-03
## ASV1967     -5.347075e-03 -5.556561e-03 -5.772839e-03 -5.996047e-03
## ASV0385      2.061753e-03  2.156672e-03  2.255583e-03  2.358606e-03
## ASV0295      6.049254e-04  6.465369e-04  6.909972e-04  7.384843e-04
## ASV0072     -4.095590e-03 -4.248397e-03 -4.405278e-03 -4.566221e-03
## ASV0157     -1.455024e-04 -1.261093e-04 -1.038893e-04 -7.859676e-05
## ASV0501      9.632766e-03  1.003961e-02  1.046148e-02  1.089874e-02
## ASV10729    -1.229378e-02 -1.282618e-02 -1.337959e-02 -1.395470e-02
## ASV1470      5.303780e-03  5.478411e-03  5.655822e-03  5.835827e-03
## ASV0050     -9.986054e-03 -1.038154e-02 -1.078974e-02 -1.121083e-02
## ASV0411     -2.485636e-03 -2.598736e-03 -2.716755e-03 -2.839889e-03
## ASV0549      3.905749e-03  4.077861e-03  4.256954e-03  4.443259e-03
## ASV0184      1.229271e-03  1.280076e-03  1.332810e-03  1.387547e-03
## ASV0705      2.308522e-03  2.394161e-03  2.482006e-03  2.572038e-03
## ASV1715      5.255252e-03  5.475054e-03  5.702898e-03  5.938995e-03
## ASV0603      8.885775e-04  9.312265e-04  9.760434e-04  1.023153e-03
## ASV0826      8.669443e-03  9.020980e-03  9.384636e-03  9.760688e-03
## ASV0034     -2.665285e-03 -2.766272e-03 -2.870127e-03 -2.976865e-03
## ASV0838      9.639498e-04  9.415481e-04  9.128961e-04  8.773589e-04
## ASV0614     -2.367756e-03 -2.463485e-03 -2.562490e-03 -2.664843e-03
## ASV0014     -6.326471e-03 -6.584510e-03 -6.851479e-03 -7.127575e-03
## ASV0585      6.873945e-06 -3.385353e-05 -7.917394e-05 -1.294172e-04
## ASV0016     -6.608593e-03 -6.878136e-03 -7.157007e-03 -7.445415e-03
## ASV5394     -5.094561e-03 -5.310614e-03 -5.534778e-03 -5.767274e-03
## ASV0666      1.015902e-02  1.053600e-02  1.092323e-02  1.132075e-02
## ASV2085      1.351291e-03  1.339770e-03  1.322705e-03  1.299595e-03
## ASV0003     -4.498190e-03 -4.681220e-03 -4.870557e-03 -5.066339e-03
## ASV0346      2.485182e-03  2.598643e-03  2.716857e-03  2.839975e-03
## ASV0267      2.122352e-04  2.342435e-04  2.579718e-04  2.835111e-04
## ASV0353      3.863633e-03  4.037172e-03  4.218016e-03  4.406428e-03
## ASV2419      9.528534e-03  9.907553e-03  1.029899e-02  1.070307e-02
## ASV0447      5.688497e-03  5.944551e-03  6.211339e-03  6.489236e-03
## ASV0654      7.847858e-03  8.168713e-03  8.500654e-03  8.843911e-03
## ASV0151      1.337346e-03  1.410032e-03  1.486729e-03  1.567644e-03
## ASV0065     -2.977039e-03 -3.095450e-03 -3.217727e-03 -3.343938e-03
## ASV0527      7.408866e-03  7.709187e-03  8.019789e-03  8.340896e-03
## ASV4055     -1.411644e-03 -1.485422e-03 -1.563331e-03 -1.645622e-03
## ASV0166     -3.512846e-03 -3.642765e-03 -3.776155e-03 -3.913021e-03
## ASV0417     -1.301486e-03 -1.341041e-03 -1.380915e-03 -1.421040e-03
## ASV0078     -2.105538e-03 -2.184200e-03 -2.264937e-03 -2.347735e-03
## ASV0322     -1.383616e-04 -1.248677e-04 -1.090132e-04 -9.055761e-05
## ASV0156     -5.509981e-03 -5.750249e-03 -6.000230e-03 -6.260267e-03
## ASV0648     -1.206098e-02 -1.259067e-02 -1.314184e-02 -1.371521e-02
## ASV0407     -9.593802e-04 -1.005086e-03 -1.052966e-03 -1.103122e-03
## ASV2030     -1.909437e-03 -1.991795e-03 -2.077858e-03 -2.167827e-03
## ASV0300      1.506258e-03  1.575898e-03  1.648574e-03  1.724397e-03
## ASV1150      3.987369e-04  4.201784e-04  4.427298e-04  4.664374e-04
## ASV0958      4.707419e-03  4.930168e-03  5.163287e-03  5.407233e-03
## ASV0216     -4.580537e-03 -4.764935e-03 -4.955931e-03 -5.153738e-03
## ASV0446      7.418261e-03  7.742050e-03  8.078674e-03  8.428531e-03
## ASV0367     -4.755745e-03 -4.958093e-03 -5.168162e-03 -5.386184e-03
## ASV0200     -2.814893e-03 -2.933459e-03 -3.056404e-03 -3.183839e-03
## ASV0334     -1.128200e-03 -1.154530e-03 -1.180479e-03 -1.205977e-03
## ASV1311      1.483127e-03  1.523959e-03  1.564603e-03  1.604926e-03
## ASV0458      2.150154e-03  2.208175e-03  2.265996e-03  2.323460e-03
## ASV1371      5.112902e-04  5.360800e-04  5.619452e-04  5.889129e-04
## ASV0418      5.704575e-03  5.913449e-03  6.127847e-03  6.347780e-03
## ASV0004      8.154165e-04  8.445116e-04  8.743093e-04  9.048053e-04
## ASV1943      1.352724e-02  1.389623e-02  1.426614e-02  1.463632e-02
## ASV1495     -1.915127e-03 -2.035646e-03 -2.163866e-03 -2.300246e-03
## ASV0901     -5.568024e-03 -5.819547e-03 -6.081969e-03 -6.355732e-03
## ASV0628      2.403975e-03  2.480396e-03  2.557709e-03  2.635794e-03
## ASV0400      1.575166e-03  1.632440e-03  1.691042e-03  1.750936e-03
## ASV0116     -1.627136e-03 -1.699895e-03 -1.775731e-03 -1.854761e-03
## ASV0788      1.446243e-02  1.511386e-02  1.579321e-02  1.650159e-02
## ASV0117      1.128165e-03  1.182212e-03  1.238769e-03  1.297942e-03
## ASV3137     -2.990111e-04 -3.101300e-04 -3.215352e-04 -3.332227e-04
## ASV0001      8.629498e-04  8.928548e-04  9.233955e-04  9.545581e-04
## ASV1651      2.517765e-03  2.609069e-03  2.702708e-03  2.798682e-03
## ASV1692      1.198004e-02  1.251479e-02  1.307196e-02  1.365236e-02
## ASV0660      3.385982e-03  3.485285e-03  3.584774e-03  3.684185e-03
## ASV0508      1.622510e-04  1.666829e-04  1.711047e-04  1.755034e-04
## ASV1660     -2.678397e-03 -2.811165e-03 -2.950254e-03 -3.095917e-03
## ASV0233      3.552163e-03  3.702208e-03  3.857897e-03  4.019395e-03
## ASV1343     -6.784293e-03 -7.085413e-03 -7.399094e-03 -7.725801e-03
## ASV0209      2.899544e-03  3.000787e-03  3.104228e-03  3.209818e-03
## ASV0193     -3.433310e-03 -3.555580e-03 -3.680620e-03 -3.808373e-03
## ASV0357      1.839726e-03  1.941215e-03  2.048563e-03  2.162110e-03
## ASV0198      2.761294e-03  2.870641e-03  2.983619e-03  3.100313e-03
## ASV0007      7.351559e-04  7.589131e-04  7.830211e-04  8.074549e-04
## ASV1772     -9.781757e-04 -9.982611e-04 -1.017011e-03 -1.034176e-03
## ASV0009      5.836565e-04  6.009509e-04  6.183530e-04  6.358315e-04
## ASV0006     -8.554046e-04 -8.959818e-04 -9.384208e-04 -9.827977e-04
## ASV0011     -2.766472e-03 -2.887129e-03 -3.012618e-03 -3.143101e-03
## ASV0015      4.389613e-04  4.517358e-04  4.645549e-04  4.773905e-04
## ASV0017      4.982150e-04  5.131001e-04  5.280944e-04  5.431726e-04
## ASV0235     -2.584021e-03 -2.698114e-03 -2.816869e-03 -2.940447e-03
## ASV0382      1.992698e-03  2.076853e-03  2.163873e-03  2.253782e-03
## ASV2357      8.323636e-03  8.687025e-03  9.065119e-03  9.458433e-03
## ASV0567     -1.660502e-03 -1.736936e-03 -1.816904e-03 -1.900575e-03
## ASV0165      1.381639e-03  1.441087e-03  1.502816e-03  1.566890e-03
## ASV0005      1.918553e-03  1.996205e-03  2.076471e-03  2.159400e-03
## ASV0384     -7.656647e-07  1.227320e-05  2.688283e-05  4.319456e-05
## ASV0002      3.396282e-04  3.524862e-04  3.657378e-04  3.793910e-04
## ASV3017      9.448689e-03  9.790074e-03  1.013987e-02  1.049801e-02
## ASV0091     -2.563026e-04 -2.671865e-04 -2.785546e-04 -2.904358e-04
## ASV0186     -3.910745e-03 -4.071351e-03 -4.237506e-03 -4.409315e-03
## ASV0370      1.996275e-03  2.073989e-03  2.154116e-03  2.236692e-03
## ASV0018      2.475162e-03  2.576450e-03  2.681247e-03  2.789626e-03
## ASV1377      2.336451e-02  2.423801e-02  2.513565e-02  2.605753e-02
## ASV0019      2.602411e-03  2.709290e-03  2.819907e-03  2.934345e-03
## ASV0023     -1.721355e-03 -1.797676e-03 -1.877109e-03 -1.959754e-03
## ASV2194      2.850819e-03  2.983326e-03  3.121860e-03  3.266685e-03
## ASV1155      9.832499e-03  1.021014e-02  1.059972e-02  1.100147e-02
## ASV0510     -2.341943e-03 -2.413246e-03 -2.485359e-03 -2.558217e-03
## ASV2371     -5.905183e-03 -6.129573e-03 -6.360693e-03 -6.598632e-03
## ASV0024     -2.130443e-03 -2.224214e-03 -2.321763e-03 -2.423211e-03
## ASV2452      5.477097e-03  5.653765e-03  5.832854e-03  6.014144e-03
## ASV2332     -1.729319e-02 -1.797187e-02 -1.867284e-02 -1.939662e-02
## ASV2591      5.664200e-03  5.945597e-03  6.239854e-03  6.547399e-03
## ASV0521      4.326068e-03  4.517053e-03  4.715874e-03  4.922805e-03
## ASV5542      4.109567e-03  4.287153e-03  4.471571e-03  4.663023e-03
## ASV0336     -7.414062e-04 -7.859524e-04 -8.331278e-04 -8.830696e-04
## ASV10102     7.603215e-03  7.933981e-03  8.277695e-03  8.634739e-03
## ASV16823    -1.010485e-02 -1.046132e-02 -1.082653e-02 -1.120050e-02
## ASV3104      5.225731e-02  5.409987e-02  5.598760e-02  5.792051e-02
## ASV0781      8.089287e-03  8.421268e-03  8.765074e-03  9.121020e-03
## ASV10899     5.905010e-03  6.214984e-03  6.541177e-03  6.884379e-03
## ASV11222    -1.777384e-02 -1.840059e-02 -1.904273e-02 -1.970025e-02
## ASV11327    -1.594942e-02 -1.651156e-02 -1.708748e-02 -1.767718e-02
## ASV12458    -1.775525e-02 -1.838072e-02 -1.902151e-02 -1.967762e-02
## ASV1636      1.062816e-02  1.103455e-02  1.145312e-02  1.188401e-02
## ASV1890     -7.585498e-03 -7.820073e-03 -8.058091e-03 -8.299399e-03
## ASV2898      1.429152e-02  1.484051e-02  1.540608e-02  1.598844e-02
## ASV8328      3.561288e-03  3.812111e-03  4.079807e-03  4.365370e-03
## ASV0709     -1.634009e-02 -1.698936e-02 -1.765964e-02 -1.835130e-02
## ASV0856      1.498481e-02  1.566655e-02  1.637734e-02  1.711823e-02
## ASV0909      5.460107e-03  5.771195e-03  6.099965e-03  6.447316e-03
## ASV0937     -1.031747e-02 -1.077768e-02 -1.125763e-02 -1.175813e-02
## ASV11390    -2.533308e-02 -2.622546e-02 -2.713970e-02 -2.807581e-02
## ASV11966     7.613818e-03  7.973239e-03  8.348664e-03  8.740684e-03
## ASV12990     4.590097e-03  4.758790e-03  4.931938e-03  5.109561e-03
## ASV14797     6.693799e-03  6.935459e-03  7.183300e-03  7.437334e-03
## ASV14904    -3.635031e-02 -3.763087e-02 -3.894283e-02 -4.028618e-02
## ASV15304     5.083224e-03  5.338326e-03  5.605672e-03  5.885753e-03
## ASV16696    -1.255592e-02 -1.299818e-02 -1.345129e-02 -1.391524e-02
## ASV1690      2.543277e-02  2.657703e-02  2.776787e-02  2.900667e-02
## ASV2029      1.600866e-02  1.664617e-02  1.730491e-02  1.798535e-02
## ASV2834      2.115678e-02  2.206099e-02  2.299955e-02  2.397341e-02
## ASV4003      1.919252e-02  2.012686e-02  2.110663e-02  2.213402e-02
## ASV4064      1.016829e-02  1.060959e-02  1.106813e-02  1.154444e-02
## ASV4294      7.097652e-03  7.461984e-03  7.844949e-03  8.247439e-03
## ASV4609      5.357310e-03  5.567737e-03  5.785140e-03  6.009702e-03
## ASV6283     -1.174452e-02 -1.215874e-02 -1.258317e-02 -1.301783e-02
## ASV6491     -1.682474e-02 -1.741784e-02 -1.802555e-02 -1.864788e-02
## ASV7453      1.019945e-02  1.068627e-02  1.119514e-02  1.172688e-02
## ASV7959      4.318183e-03  4.558686e-03  4.812456e-03  5.080158e-03
## ASV8219      1.453894e-01  1.505158e-01  1.557688e-01  1.611484e-01
## ASV8547     -1.505409e-02 -1.558463e-02 -1.612825e-02 -1.668496e-02
## ASV9319      7.820571e-03  8.175613e-03  8.545967e-03  8.932234e-03
## ASV9382     -2.944898e-02 -3.048678e-02 -3.155018e-02 -3.263921e-02
## ASV11516    -1.965927e-02 -2.035174e-02 -2.106126e-02 -2.178785e-02
## ASV14377    -1.418764e-02 -1.468713e-02 -1.519890e-02 -1.572297e-02
## ASV1867      1.275087e-02  1.330824e-02  1.388794e-02  1.449074e-02
## ASV1895      5.322157e-03  5.488938e-03  5.657267e-03  5.826837e-03
## ASV3168      7.047991e-03  7.295677e-03  7.548763e-03  7.807142e-03
## ASV4449      4.249805e-02  4.426068e-02  4.608863e-02  4.798391e-02
## ASV6596      1.027657e-02  1.078785e-02  1.132447e-02  1.188763e-02
## ASV7492     -3.340006e-04 -2.753530e-04 -2.094518e-04 -1.357838e-04
## ASV9854     -2.966064e-03 -3.067727e-03 -3.171789e-03 -3.278248e-03
## ASV6296      2.379498e-01  2.463244e-01  2.549049e-01  2.636916e-01
## ASV4201      2.671032e-03  2.863785e-03  3.069774e-03  3.289800e-03
## ASV0552      8.744591e-03  9.121582e-03  9.513174e-03  9.919797e-03
## ASV3671     -5.569684e-03 -5.802197e-03 -6.044037e-03 -6.295609e-03
## ASV3529     -4.913140e-04 -4.601084e-04 -4.245942e-04 -3.845161e-04
## ASV1060      2.482973e-03  2.601022e-03  2.724711e-03  2.854312e-03
## ASV0239     -2.648583e-03 -2.735239e-03 -2.823386e-03 -2.912964e-03
## ASV5711     -1.326417e-02 -1.378617e-02 -1.432547e-02 -1.488246e-02
## ASV4152     -1.974372e-02 -2.057574e-02 -2.143899e-02 -2.233439e-02
## ASV1461      8.657100e-03  8.945895e-03  9.239984e-03  9.539177e-03
## ASV2877      4.588435e-03  4.746409e-03  4.907571e-03  5.071827e-03
## ASV0012      8.852296e-04  9.221559e-04  9.604502e-04  1.000153e-03
## ASV9823      7.701545e-04  7.707367e-04  7.686531e-04  7.636115e-04
## ASV0008      9.333270e-04  9.716786e-04  1.011415e-03  1.052577e-03
## ASV7832     -1.179861e-02 -1.230933e-02 -1.284055e-02 -1.339300e-02
## ASV1915     -1.390924e-03 -1.447720e-03 -1.506860e-03 -1.568465e-03
## ASV0055     -1.221018e-03 -1.284014e-03 -1.350260e-03 -1.419914e-03
## ASV0032      3.483193e-04  3.557719e-04  3.630000e-04  3.699693e-04
## ASV2977     -1.625466e-02 -1.693159e-02 -1.763324e-02 -1.836028e-02
## ASV0466      1.148707e-02  1.187204e-02  1.226409e-02  1.266294e-02
## ASV3866      9.402559e-03  9.823120e-03  1.026147e-02  1.071830e-02
## ASV0040      3.285818e-03  3.426085e-03  3.571744e-03  3.722957e-03
## ASV0496     -1.421482e-03 -1.519414e-03 -1.623837e-03 -1.735117e-03
## ASV0052      2.764582e-03  2.882887e-03  3.005761e-03  3.133347e-03
## ASV3828     -8.377641e-03 -8.669283e-03 -8.967829e-03 -9.273259e-03
## ASV1930      4.482055e-03  4.645198e-03  4.812301e-03  4.983312e-03
## ASV2126      8.009578e-03  8.329295e-03  8.659763e-03  9.001229e-03
## ASV0793      1.054057e-02  1.100379e-02  1.148574e-02  1.198706e-02
## ASV0299     -2.645480e-04 -2.820256e-04 -3.009634e-04 -3.215005e-04
## ASV0208      7.444108e-03  7.763034e-03  8.094442e-03  8.438750e-03
## ASV0511     -2.565704e-03 -2.646662e-03 -2.728733e-03 -2.811846e-03
## ASV1123     -7.977856e-03 -8.246389e-03 -8.520255e-03 -8.799327e-03
## ASV0099      3.681411e-04  3.899980e-04  4.132574e-04  4.380113e-04
## ASV0752     -5.650831e-03 -5.912419e-03 -6.185570e-03 -6.470742e-03
## ASV0883      7.679127e-03  8.029572e-03  8.394972e-03  8.775854e-03
## ASV0683      9.872522e-03  1.031550e-02  1.077709e-02  1.125796e-02
## ASV4117     -1.516507e-02 -1.581894e-02 -1.649894e-02 -1.720598e-02
## ASV2172      6.709709e-04  6.805640e-04  6.890134e-04  6.961727e-04
## ASV0330     -2.874794e-03 -3.000673e-03 -3.131684e-03 -3.268014e-03
## ASV0728      1.360436e-02  1.416134e-02  1.473775e-02  1.533405e-02
## ASV0499      3.877528e-03  4.053973e-03  4.238051e-03  4.430054e-03
## ASV0120     -6.057290e-03 -6.306168e-03 -6.563704e-03 -6.830080e-03
## ASV1446      3.529828e-03  3.610151e-03  3.688405e-03  3.764180e-03
## ASV17171    -1.174375e-02 -1.223700e-02 -1.274919e-02 -1.328096e-02
## ASV0533      1.010276e-03  1.060343e-03  1.112846e-03  1.167891e-03
## ASV2495     -3.580242e-03 -3.773875e-03 -3.978226e-03 -4.193850e-03
## ASV5582      4.399179e-03  4.521927e-03  4.644753e-03  4.767377e-03
## ASV1488      1.899650e-03  1.966631e-03  2.034939e-03  2.104505e-03
## ASV0682      2.850994e-03  2.981824e-03  3.118342e-03  3.260762e-03
## ASV0068     -4.631116e-03 -4.823907e-03 -5.023567e-03 -5.230247e-03
## ASV1987     -1.253591e-02 -1.312009e-02 -1.373028e-02 -1.436748e-02
## ASV0035     -1.304833e-03 -1.388651e-03 -1.478093e-03 -1.573532e-03
## ASV7192     -6.829837e-03 -7.096381e-03 -7.371328e-03 -7.654806e-03
## ASV0873     -7.765993e-03 -8.467465e-03 -9.219453e-03 -1.002465e-02
## ASV4749     -1.548067e-03 -1.691795e-03 -1.846872e-03 -2.014030e-03
## ASV2174      4.116736e-03  4.237189e-03  4.358133e-03  4.479308e-03
## ASV1476     -5.502094e-03 -5.758384e-03 -6.026367e-03 -6.306545e-03
## ASV0740     -1.545828e-02 -1.616434e-02 -1.690127e-02 -1.767029e-02
## ASV0170     -2.859515e-03 -2.980596e-03 -3.106279e-03 -3.236708e-03
## ASV2466     -1.309740e-02 -1.365818e-02 -1.424097e-02 -1.484654e-02
## ASV1709      4.506509e-03  4.688607e-03  4.877862e-03  5.074615e-03
## ASV6170     -2.114247e-02 -2.208149e-02 -2.305950e-02 -2.407791e-02
## ASV3673      1.059204e-02  1.107437e-02  1.157756e-02  1.210241e-02
## ASV1745     -2.944177e-03 -3.089661e-03 -3.242246e-03 -3.402250e-03
##                                                                    
## (Intercept)  8.131192e-02  8.462548e-02  8.805230e-02  9.159468e-02
## ASV1236      1.484074e-02  1.538772e-02  1.594993e-02  1.652754e-02
## ASV0421      2.611688e-03  2.759322e-03  2.914891e-03  3.078729e-03
## ASV0691     -9.805779e-03 -1.007435e-02 -1.034401e-02 -1.061442e-02
## ASV0899      1.287632e-02  1.334403e-02  1.382351e-02  1.431470e-02
## ASV1004      2.981936e-02  3.091726e-02  3.204502e-02  3.320281e-02
## ASV1041     -1.197220e-02 -1.238785e-02 -1.281188e-02 -1.324399e-02
## ASV1058      1.857836e-02  1.926320e-02  1.996701e-02  2.068999e-02
## ASV12542     6.866359e-03  7.102269e-03  7.343644e-03  7.590490e-03
## ASV1294      1.734890e-02  1.799190e-02  1.865305e-02  1.933253e-02
## ASV13113     7.038082e-03  7.373253e-03  7.724074e-03  8.091227e-03
## ASV1318      1.723669e-02  1.787009e-02  1.852071e-02  1.918868e-02
## ASV2269     -2.950816e-02 -3.056566e-02 -3.164891e-02 -3.275772e-02
## ASV2542      1.644100e-02  1.715882e-02  1.790569e-02  1.868264e-02
## ASV2660     -1.162258e-02 -1.203432e-02 -1.245594e-02 -1.288741e-02
## ASV2737      3.708870e-03  3.826091e-03  3.945449e-03  4.066930e-03
## ASV2840      1.462314e-02  1.508951e-02  1.556285e-02  1.604275e-02
## ASV3053      7.767355e-02  8.035946e-02  8.310800e-02  8.591911e-02
## ASV3077      5.018206e-03  5.196537e-03  5.379532e-03  5.567244e-03
## ASV3134      1.087989e-02  1.138047e-02  1.190328e-02  1.244924e-02
## ASV3140      1.350393e-02  1.405596e-02  1.462718e-02  1.521799e-02
## ASV3579      5.695395e-03  5.979374e-03  6.277191e-03  6.589439e-03
## ASV6119     -8.072208e-03 -8.361480e-03 -8.657808e-03 -8.961150e-03
## ASV7557     -1.639345e-02 -1.698049e-02 -1.758183e-02 -1.819737e-02
## ASV8422      3.995878e-03  4.136901e-03  4.281559e-03  4.429892e-03
## ASV1086     -5.203270e-04 -5.342710e-04 -5.484135e-04 -5.627690e-04
## ASV1310      7.912149e-03  8.199919e-03  8.495197e-03  8.797997e-03
## ASV15750    -9.183562e-04 -9.420231e-04 -9.654605e-04 -9.885891e-04
## ASV16905    -3.371137e-03 -3.491877e-03 -3.615561e-03 -3.742169e-03
## ASV2033      1.677657e-02  1.751671e-02  1.828659e-02  1.908714e-02
## ASV2089      7.123717e-03  7.379577e-03  7.641716e-03  7.910097e-03
## ASV2127      2.330948e-02  2.416333e-02  2.504027e-02  2.594048e-02
## ASV2725      1.802497e-02  1.865074e-02  1.929079e-02  1.994503e-02
## ASV2804     -6.977633e-03 -7.227593e-03 -7.483658e-03 -7.745795e-03
## ASV3075      1.663497e-02  1.732213e-02  1.803517e-02  1.877497e-02
## ASV3327      2.398666e-02  2.501346e-02  2.607959e-02  2.718620e-02
## ASV3342      2.036674e-02  2.122879e-02  2.212356e-02  2.305203e-02
## ASV3532     -2.196918e-02 -2.287650e-02 -2.381715e-02 -2.479215e-02
## ASV3600      1.030419e-02  1.073341e-02  1.117846e-02  1.163976e-02
## ASV4013      1.824563e-02  1.895057e-02  1.967718e-02  2.042576e-02
## ASV4136      1.829958e-02  1.895154e-02  1.962024e-02  2.030578e-02
## ASV4195      7.118346e-02  7.373218e-02  7.634310e-02  7.901586e-02
## ASV4407     -2.748541e-02 -2.846882e-02 -2.947618e-02 -3.050733e-02
## ASV4717      4.241224e-03  4.368010e-03  4.496550e-03  4.626798e-03
## ASV6794      1.089295e-02  1.126493e-02  1.164567e-02  1.203523e-02
## ASV8324     -1.410301e-02 -1.460756e-02 -1.512440e-02 -1.565345e-02
## ASV8981      9.593359e-05  1.261997e-04  1.595536e-04  1.962126e-04
## ASV9859      6.690558e-03  7.042113e-03  7.412542e-03  7.802836e-03
## ASV0936      1.530707e-02  1.594643e-02  1.660875e-02  1.729453e-02
## ASV12683    -1.276239e-04 -1.367089e-04 -1.461652e-04 -1.559770e-04
## ASV1293      9.136400e-03  9.464423e-03  9.800729e-03  1.014532e-02
## ASV13055     1.086936e-04  1.319506e-04  1.574423e-04  1.853189e-04
## ASV17063    -7.302945e-03 -7.563817e-03 -7.831031e-03 -8.104552e-03
## ASV2228      5.951884e-03  6.164341e-03  6.381953e-03  6.604689e-03
## ASV2769      1.397471e-03  1.472643e-03  1.551573e-03  1.634396e-03
## ASV2803      6.003939e-03  6.197236e-03  6.393955e-03  6.594013e-03
## ASV2896      5.982553e-03  6.249676e-03  6.528377e-03  6.819148e-03
## ASV3062      7.856055e-03  8.232615e-03  8.626438e-03  9.038198e-03
## ASV3107      1.085785e-02  1.132280e-02  1.180600e-02  1.230805e-02
## ASV3265      1.298280e-02  1.344352e-02  1.391544e-02  1.439852e-02
## ASV3666      6.057764e-05  5.815327e-05  5.521383e-05  5.171229e-05
## ASV4497      4.603818e-03  4.775657e-03  4.952377e-03  5.134030e-03
## ASV6914     -9.744519e-04 -1.026519e-03 -1.081251e-03 -1.138761e-03
## ASV0576     -1.424699e-02 -1.468907e-02 -1.513751e-02 -1.559198e-02
## ASV0673      1.802410e-02  1.871145e-02  1.941934e-02  2.014804e-02
## ASV0772      8.563031e-03  8.902877e-03  9.254165e-03  9.617176e-03
## ASV0862      1.986932e-03  2.124770e-03  2.271126e-03  2.426381e-03
## ASV0898      7.381929e-03  7.710154e-03  8.051548e-03  8.406502e-03
## ASV0910      8.223191e-03  8.578523e-03  8.947891e-03  9.331755e-03
## ASV0964     -5.528284e-03 -5.706510e-03 -5.887718e-03 -6.071797e-03
## ASV10059     6.275818e-03  6.568521e-03  6.874258e-03  7.193533e-03
## ASV10263    -1.116394e-02 -1.156511e-02 -1.197627e-02 -1.239740e-02
## ASV1088      1.445542e-02  1.507523e-02  1.571981e-02  1.639006e-02
## ASV1101      1.585378e-02  1.641839e-02  1.699678e-02  1.758889e-02
## ASV1183      4.607209e-03  4.796141e-03  4.991851e-03  5.194527e-03
## ASV11956     3.695130e-03  3.809699e-03  3.926077e-03  4.044220e-03
## ASV12774    -1.304634e-04 -1.558422e-04 -1.835115e-04 -2.136086e-04
## ASV1321      2.158564e-02  2.253460e-02  2.352189e-02  2.454875e-02
## ASV13793    -7.694173e-03 -7.970449e-03 -8.253582e-03 -8.543552e-03
## ASV14482     4.024821e-04  4.144708e-04  4.268065e-04  4.395178e-04
## ASV15483     3.567808e-03  3.718909e-03  3.875632e-03  4.038125e-03
## ASV2062      1.544911e-02  1.604838e-02  1.666669e-02  1.730440e-02
## ASV2132      1.350307e-02  1.407271e-02  1.466357e-02  1.527625e-02
## ASV2413      1.158187e-02  1.201238e-02  1.245526e-02  1.291069e-02
## ASV2490      3.373424e-02  3.488169e-02  3.605390e-02  3.725061e-02
## ASV2594      4.883103e-03  5.091775e-03  5.308921e-03  5.534880e-03
## ASV2822     -2.033880e-02 -2.107132e-02 -2.182225e-02 -2.259156e-02
## ASV2863      2.130709e-02  2.206591e-02  2.284412e-02  2.364185e-02
## ASV2910      7.905810e-03  8.191737e-03  8.485160e-03  8.786119e-03
## ASV2980      9.273918e-03  9.633880e-03  1.000512e-02  1.038783e-02
## ASV3307      1.616302e-02  1.674417e-02  1.733985e-02  1.795003e-02
## ASV3474      1.261587e-02  1.318274e-02  1.377330e-02  1.438837e-02
## ASV3502      1.214361e-02  1.263631e-02  1.314628e-02  1.367398e-02
## ASV4236      1.555946e-02  1.606823e-02  1.658604e-02  1.711262e-02
## ASV4842     -1.974157e-03 -2.050491e-03 -2.128584e-03 -2.208360e-03
## ASV4894     -7.707979e-03 -7.985667e-03 -8.270355e-03 -8.562036e-03
## ASV5290      6.784345e-03  7.066302e-03  7.358402e-03  7.660899e-03
## ASV5501      4.116229e-03  4.291045e-03  4.473025e-03  4.662477e-03
## ASV5795      4.598149e-03  4.791656e-03  4.992319e-03  5.200325e-03
## ASV5987     -2.154661e-02 -2.232401e-02 -2.312113e-02 -2.393798e-02
## ASV6267     -2.426355e-02 -2.513834e-02 -2.603527e-02 -2.695435e-02
## ASV6862      9.396982e-03  9.721575e-03  1.005378e-02  1.039358e-02
## ASV7145      4.061015e-03  4.200954e-03  4.344615e-03  4.492081e-03
## ASV7673     -7.708186e-03 -7.986040e-03 -8.270925e-03 -8.562840e-03
## ASV7789      5.079084e-03  5.337381e-03  5.608700e-03  5.893643e-03
## ASV7809      7.094415e-04  7.600438e-04  8.138732e-04  8.710838e-04
## ASV8002     -9.737986e-03 -1.008937e-02 -1.044970e-02 -1.081898e-02
## ASV8205      4.503764e-03  4.692012e-03  4.887279e-03  5.089770e-03
## ASV9155     -2.345002e-03 -2.422020e-03 -2.500375e-03 -2.580014e-03
## ASV9221      1.834746e-03  1.950186e-03  2.072728e-03  2.202754e-03
## ASV9311     -1.562134e-02 -1.618534e-02 -1.676375e-02 -1.735658e-02
## ASV9557     -1.066934e-02 -1.105427e-02 -1.144901e-02 -1.185358e-02
## ASV9936     -2.150275e-02 -2.227796e-02 -2.307288e-02 -2.388755e-02
## ASV1445      1.441241e-02  1.501001e-02  1.562919e-02  1.627052e-02
## ASV4232      6.102913e-03  6.396278e-03  6.703893e-03  7.026458e-03
## ASV6479      2.939614e-03  3.115558e-03  3.301984e-03  3.499457e-03
## ASV0142     -9.155442e-03 -9.481145e-03 -9.815003e-03 -1.015703e-02
## ASV0378      5.123108e-03  5.360174e-03  5.607467e-03  5.865335e-03
## ASV1122      1.417390e-02  1.477432e-02  1.539748e-02  1.604406e-02
## ASV0123     -8.046850e-03 -8.330855e-03 -8.621777e-03 -8.919610e-03
## ASV2064      3.654716e-03  3.754373e-03  3.853751e-03  3.952576e-03
## ASV4459     -4.265629e-04 -4.354466e-04 -4.443704e-04 -4.533659e-04
## ASV0448      4.107958e-03  4.298936e-03  4.498294e-03  4.706343e-03
## ASV0397      7.920604e-03  8.233995e-03  8.557603e-03  8.891620e-03
## ASV0485      8.958616e-03  9.301477e-03  9.654845e-03  1.001889e-02
## ASV1566      1.347104e-02  1.399923e-02  1.454431e-02  1.510659e-02
## ASV1365      1.177399e-02  1.224705e-02  1.273568e-02  1.324011e-02
## ASV1065      1.672325e-02  1.740011e-02  1.810026e-02  1.882424e-02
## ASV0722     -9.759669e-04 -1.022645e-03 -1.071650e-03 -1.123108e-03
## ASV12660    -8.669203e-03 -8.973594e-03 -9.285357e-03 -9.604484e-03
## ASV0223      2.510445e-03  2.609153e-03  2.711164e-03  2.816560e-03
## ASV0229      4.117217e-03  4.294306e-03  4.478385e-03  4.669693e-03
## ASV0877      1.213281e-03  1.233140e-03  1.250864e-03  1.266132e-03
## ASV0983      8.744542e-03  9.069308e-03  9.403091e-03  9.745954e-03
## ASV0626      1.721027e-03  1.826517e-03  1.937950e-03  2.055574e-03
## ASV4146      3.289688e-04  3.295713e-04  3.285428e-04  3.256414e-04
## ASV4175     -1.175837e-02 -1.225079e-02 -1.276131e-02 -1.329041e-02
## ASV2082     -6.916758e-03 -7.298282e-03 -7.701123e-03 -8.126393e-03
## ASV2272      5.576475e-03  5.811331e-03  6.055183e-03  6.308323e-03
## ASV2245     -8.494092e-03 -8.854457e-03 -9.228362e-03 -9.616183e-03
## ASV0590     -6.907935e-03 -7.301399e-03 -7.717202e-03 -8.156495e-03
## ASV0217      1.497977e-03  1.614447e-03  1.738821e-03  1.871514e-03
## ASV0416      4.892918e-03  5.021053e-03  5.148528e-03  5.275000e-03
## ASV1056      8.476825e-03  8.849276e-03  9.236507e-03  9.638960e-03
## ASV7777     -1.135823e-02 -1.183369e-02 -1.232719e-02 -1.283930e-02
## ASV0455      1.981805e-03  2.060430e-03  2.141557e-03  2.225217e-03
## ASV0604      5.731320e-03  5.990754e-03  6.261031e-03  6.542518e-03
## ASV6100     -8.065924e-03 -8.416795e-03 -8.781960e-03 -9.161951e-03
## ASV11359    -1.671918e-02 -1.740541e-02 -1.811564e-02 -1.885040e-02
## ASV6604      2.497297e-03  2.609332e-03  2.725979e-03  2.847385e-03
## ASV5004     -5.878454e-03 -6.118683e-03 -6.367568e-03 -6.625366e-03
## ASV1483     -2.479218e-03 -2.576937e-03 -2.677826e-03 -2.781944e-03
## ASV9773     -7.669585e-03 -7.994655e-03 -8.332219e-03 -8.682682e-03
## ASV4059      8.467598e-04  9.252259e-04  1.009552e-03  1.100062e-03
## ASV1193      8.871919e-03  9.225680e-03  9.591295e-03  9.969026e-03
## ASV4610     -3.705979e-04 -3.360985e-04 -2.974527e-04 -2.544474e-04
## ASV0742      6.384926e-05  1.123911e-04  1.655937e-04  2.237101e-04
## ASV1502     -9.940257e-04 -1.064780e-03 -1.140060e-03 -1.220087e-03
## ASV0195     -1.298580e-04 -1.525635e-04 -1.772245e-04 -2.039530e-04
## ASV1213      5.356321e-03  5.522994e-03  5.691914e-03  5.862921e-03
## ASV1648     -7.228657e-03 -7.543342e-03 -7.870987e-03 -8.212097e-03
## ASV6984     -6.789965e-03 -7.087475e-03 -7.397423e-03 -7.720310e-03
## ASV0396     -3.613738e-06  1.214036e-05  2.917606e-05  4.751348e-05
## ASV4297      8.119870e-03  8.393033e-03  8.671687e-03  8.955725e-03
## ASV2622      1.328979e-02  1.377916e-02  1.428205e-02  1.479860e-02
## ASV3512      6.847795e-03  7.200472e-03  7.571509e-03  7.961825e-03
## ASV2411      1.052787e-02  1.099933e-02  1.149043e-02  1.200187e-02
## ASV2291     -6.126893e-03 -6.479039e-03 -6.851003e-03 -7.243748e-03
## ASV0807      1.304548e-02  1.356124e-02  1.409352e-02  1.464260e-02
## ASV1292      2.540014e-03  2.609754e-03  2.679694e-03  2.749726e-03
## ASV1035      1.113905e-02  1.154303e-02  1.195809e-02  1.238435e-02
## ASV0070      5.187318e-04  5.625995e-04  6.097329e-04  6.603311e-04
## ASV0255      8.856478e-04  9.052640e-04  9.240900e-04  9.419729e-04
## ASV0057     -2.817130e-03 -2.903402e-03 -2.990606e-03 -3.078631e-03
## ASV0077     -4.500808e-04 -4.550200e-04 -4.592352e-04 -4.626645e-04
## ASV0625      6.230951e-03  6.443958e-03  6.661536e-03  6.883625e-03
## ASV2464      4.229972e-02  4.375782e-02  4.524962e-02  4.677499e-02
## ASV1315      1.386928e-02  1.449770e-02  1.515278e-02  1.583548e-02
## ASV2673      1.194397e-02  1.248798e-02  1.305534e-02  1.364691e-02
## ASV2161      5.036005e-03  5.266118e-03  5.506330e-03  5.757051e-03
## ASV0337     -2.715153e-03 -2.830006e-03 -2.949201e-03 -3.072867e-03
## ASV7680     -1.788540e-02 -1.865172e-02 -1.944775e-02 -2.027441e-02
## ASV0611      1.005212e-02  1.048758e-02  1.094044e-02  1.141129e-02
## ASV3118     -1.105802e-02 -1.156609e-02 -1.209614e-02 -1.264899e-02
## ASV1284      8.261122e-04  7.108095e-04  5.800144e-04  4.325177e-04
## ASV0889      6.892098e-03  7.155920e-03  7.428054e-03  7.708687e-03
## ASV4649     -3.662369e-03 -3.813382e-03 -3.969890e-03 -4.132049e-03
## ASV1108     -8.573400e-03 -8.983934e-03 -9.413542e-03 -9.863018e-03
## ASV0738      5.356816e-03  5.643287e-03  5.945121e-03  6.263086e-03
## ASV0473     -1.263978e-03 -1.334678e-03 -1.408863e-03 -1.486631e-03
## ASV0598     -2.984954e-03 -3.156252e-03 -3.337532e-03 -3.529338e-03
## ASV0429      4.842566e-03  5.009144e-03  5.179141e-03  5.352466e-03
## ASV1549      1.106105e-02  1.156677e-02  1.209429e-02  1.264442e-02
## ASV1203      7.514068e-03  7.799009e-03  8.092289e-03  8.393994e-03
## ASV4532      1.809626e-04  1.822913e-04  1.834868e-04  1.845668e-04
## ASV0274      1.632383e-03  1.710151e-03  1.791189e-03  1.875577e-03
## ASV0163     -5.395168e-03 -5.581098e-03 -5.771454e-03 -5.966261e-03
## ASV1298      4.844443e-04  4.992748e-04  5.148282e-04  5.312088e-04
## ASV9424     -1.409211e-02 -1.471130e-02 -1.535602e-02 -1.602724e-02
## ASV0412      1.287106e-02  1.335250e-02  1.384774e-02  1.435692e-02
## ASV0284      2.067171e-03  2.108991e-03  2.149078e-03  2.187162e-03
## ASV0620     -3.642799e-03 -3.834903e-03 -4.036938e-03 -4.249357e-03
## ASV0153     -1.474509e-02 -1.541524e-02 -1.611379e-02 -1.684174e-02
## ASV0498      4.877760e-03  5.080483e-03  5.290151e-03  5.506866e-03
## ASV0097      2.904033e-03  3.036909e-03  3.175528e-03  3.320104e-03
## ASV0104     -1.806318e-02 -1.876608e-02 -1.949073e-02 -2.023743e-02
## ASV1282      5.661461e-03  5.847786e-03  6.036853e-03  6.228412e-03
## ASV3883     -6.066163e-03 -6.361240e-03 -6.669863e-03 -6.992530e-03
## ASV0801      2.621209e-03  2.733727e-03  2.850736e-03  2.972409e-03
## ASV1611     -1.288393e-02 -1.346014e-02 -1.406051e-02 -1.468590e-02
## ASV0227     -2.992103e-03 -3.157241e-03 -3.331289e-03 -3.514669e-03
## ASV0833      4.157373e-03  4.330765e-03  4.510424e-03  4.696507e-03
## ASV0718      1.851148e-02  1.928453e-02  2.008607e-02  2.091687e-02
## ASV1139      1.270505e-03  1.264548e-03  1.254002e-03  1.238450e-03
## ASV0766     -3.027971e-03 -3.175413e-03 -3.329620e-03 -3.490840e-03
## ASV2091      1.309215e-02  1.353803e-02  1.399310e-02  1.445717e-02
## ASV1238     -1.443978e-02 -1.508699e-02 -1.576242e-02 -1.646728e-02
## ASV9193     -2.303688e-03 -2.454345e-03 -2.614904e-03 -2.785965e-03
## ASV0290      1.354063e-03  1.383252e-03  1.412041e-03  1.440392e-03
## ASV0231      5.041100e-03  5.226798e-03  5.417414e-03  5.612944e-03
## ASV0185      4.075652e-03  4.292261e-03  4.520402e-03  4.760646e-03
## ASV2330      5.279586e-03  5.449131e-03  5.621552e-03  5.796764e-03
## ASV3119     -3.625525e-03 -3.814787e-03 -4.013855e-03 -4.223195e-03
## ASV2368     -7.773179e-03 -8.139689e-03 -8.523372e-03 -8.925021e-03
## ASV0122     -3.222134e-03 -3.346611e-03 -3.474967e-03 -3.607266e-03
## ASV1044      9.297961e-03  9.715011e-03  1.014970e-02  1.060268e-02
## ASV0160     -3.102457e-03 -3.204437e-03 -3.308427e-03 -3.414409e-03
## ASV0326      9.682206e-04  1.007397e-03  1.047795e-03  1.089417e-03
## ASV1388      1.681239e-02  1.746340e-02  1.813443e-02  1.882574e-02
## ASV0792      1.179662e-02  1.221810e-02  1.264995e-02  1.309213e-02
## ASV0036     -4.416780e-03 -4.616243e-03 -4.823960e-03 -5.040193e-03
## ASV2125      1.220828e-02  1.269090e-02  1.318905e-02  1.370297e-02
## ASV1075     -2.059640e-04 -2.166637e-04 -2.280619e-04 -2.402166e-04
## ASV0390      7.371501e-03  7.713898e-03  8.071810e-03  8.445903e-03
## ASV3790     -9.794130e-03 -1.021330e-02 -1.064873e-02 -1.110095e-02
## ASV1535     -3.391683e-03 -3.565363e-03 -3.747723e-03 -3.939138e-03
## ASV0263      1.160357e-02  1.207918e-02  1.257164e-02  1.308137e-02
## ASV0675      1.840252e-02  1.920880e-02  2.004762e-02  2.092005e-02
## ASV3348      1.660403e-03  1.740928e-03  1.825158e-03  1.913232e-03
## ASV0058     -4.933623e-03 -5.122393e-03 -5.316764e-03 -5.516793e-03
## ASV4142      6.518650e-03  6.746708e-03  6.980053e-03  7.218661e-03
## ASV0059     -3.905489e-03 -4.051130e-03 -4.200793e-03 -4.354496e-03
## ASV0013     -7.364643e-03 -7.663762e-03 -7.973230e-03 -8.293285e-03
## ASV0033     -3.813553e-03 -3.984833e-03 -4.163174e-03 -4.348802e-03
## ASV4354     -4.415881e-03 -4.602489e-03 -4.796398e-03 -4.997865e-03
## ASV0022     -3.217776e-03 -3.362494e-03 -3.513230e-03 -3.670184e-03
## ASV0134     -3.306637e-03 -3.468728e-03 -3.638677e-03 -3.816846e-03
## ASV0415      6.431807e-04  6.774689e-04  7.133466e-04  7.508561e-04
## ASV10103    -1.740655e-02 -1.817014e-02 -1.896460e-02 -1.979098e-02
## ASV1613      1.116834e-02  1.156355e-02  1.196782e-02  1.238101e-02
## ASV0135     -1.310377e-03 -1.349877e-03 -1.389744e-03 -1.429925e-03
## ASV0469     -1.505623e-02 -1.563500e-02 -1.623200e-02 -1.684763e-02
## ASV0471      9.550143e-03  9.936288e-03  1.033586e-02  1.074920e-02
## ASV0451     -2.310626e-03 -2.443303e-03 -2.583395e-03 -2.731252e-03
## ASV0747      5.586370e-03  5.818657e-03  6.059252e-03  6.308345e-03
## ASV1314     -6.159990e-03 -6.449180e-03 -6.751663e-03 -7.068015e-03
## ASV0425     -1.764985e-02 -1.827052e-02 -1.890600e-02 -1.955627e-02
## ASV0559     -4.833185e-03 -5.035295e-03 -5.245477e-03 -5.464070e-03
## ASV0148     -5.658260e-04 -5.595211e-04 -5.506826e-04 -5.390773e-04
## ASV0129      2.135161e-03  2.278025e-03  2.430300e-03  2.592541e-03
## ASV1072      9.416294e-04  9.597342e-04  9.768308e-04  9.927700e-04
## ASV2390      8.522443e-03  8.787188e-03  9.054812e-03  9.324933e-03
## ASV0548      6.508504e-03  6.766890e-03  7.033698e-03  7.309076e-03
## ASV0168     -3.210983e-03 -3.332363e-03 -3.457348e-03 -3.585991e-03
## ASV0066     -3.663707e-03 -3.802992e-03 -3.946260e-03 -4.093528e-03
## ASV0468     -2.061096e-03 -2.147551e-03 -2.237299e-03 -2.330449e-03
## ASV0172     -8.247568e-04 -8.406980e-04 -8.558308e-04 -8.700375e-04
## ASV0236      1.027509e-03  1.135552e-03  1.252266e-03  1.378184e-03
## ASV0250      6.547690e-03  6.879007e-03  7.227093e-03  7.592751e-03
## ASV0338      2.760551e-03  2.880112e-03  3.003996e-03  3.132273e-03
## ASV0450     -7.583704e-04 -8.045767e-04 -8.536031e-04 -9.056087e-04
## ASV0377      4.556350e-03  4.729011e-03  4.906608e-03  5.089167e-03
## ASV1022     -1.219091e-04 -1.207075e-04 -1.187924e-04 -1.160738e-04
## ASV6174     -2.617745e-04 -2.817999e-04 -3.032677e-04 -3.262571e-04
## ASV0786     -1.146455e-03 -1.216534e-03 -1.290561e-03 -1.368700e-03
## ASV0053     -5.221079e-03 -5.435742e-03 -5.657989e-03 -5.888000e-03
## ASV0697     -2.900153e-03 -3.006587e-03 -3.116031e-03 -3.228529e-03
## ASV0785      6.331788e-03  6.573860e-03  6.823192e-03  7.079880e-03
## ASV1967     -6.226320e-03 -6.463792e-03 -6.708597e-03 -6.960865e-03
## ASV0385      2.465859e-03  2.577458e-03  2.693516e-03  2.814141e-03
## ASV0295      7.891852e-04  8.432955e-04  9.010202e-04  9.625730e-04
## ASV0072     -4.731202e-03 -4.900185e-03 -5.073126e-03 -5.249965e-03
## ASV0157     -4.997077e-05 -1.773463e-05  1.840461e-05  5.875665e-05
## ASV0501      1.135178e-02  1.182095e-02  1.230660e-02  1.280907e-02
## ASV10729    -1.455218e-02 -1.517274e-02 -1.581708e-02 -1.648593e-02
## ASV1470      6.018224e-03  6.202788e-03  6.389275e-03  6.577420e-03
## ASV0050     -1.164501e-02 -1.209246e-02 -1.255334e-02 -1.302781e-02
## ASV0411     -2.968344e-03 -3.102329e-03 -3.242063e-03 -3.387773e-03
## ASV0549      4.637010e-03  4.838447e-03  5.047810e-03  5.265345e-03
## ASV0184      1.444358e-03  1.503323e-03  1.564525e-03  1.628048e-03
## ASV0705      2.664230e-03  2.758545e-03  2.854942e-03  2.953368e-03
## ASV1715      6.183554e-03  6.436785e-03  6.698897e-03  6.970098e-03
## ASV0603      1.072689e-03  1.124794e-03  1.179620e-03  1.237329e-03
## ASV0826      1.014942e-02  1.055110e-02  1.096601e-02  1.139443e-02
## ASV0034     -3.086496e-03 -3.199024e-03 -3.314449e-03 -3.432766e-03
## ASV0838      8.342554e-04  7.828560e-04  7.223798e-04  6.519928e-04
## ASV0614     -2.770616e-03 -2.879880e-03 -2.992704e-03 -3.109157e-03
## ASV0014     -7.412991e-03 -7.707917e-03 -8.012542e-03 -8.327046e-03
## ASV0585     -1.849263e-04 -2.460564e-04 -3.131744e-04 -3.866583e-04
## ASV0016     -7.743560e-03 -8.051644e-03 -8.369861e-03 -8.698404e-03
## ASV5394     -6.008323e-03 -6.258146e-03 -6.516959e-03 -6.784978e-03
## ASV0666      1.172856e-02  1.214667e-02  1.257507e-02  1.301374e-02
## ASV2085      1.269915e-03  1.233113e-03  1.188613e-03  1.135811e-03
## ASV0003     -5.268702e-03 -5.477780e-03 -5.693705e-03 -5.916604e-03
## ASV0346      2.968145e-03  3.101515e-03  3.240231e-03  3.384439e-03
## ASV0267      3.109521e-04  3.403847e-04  3.718972e-04  4.055750e-04
## ASV0353      4.602678e-03  4.807041e-03  5.019795e-03  5.241227e-03
## ASV2419      1.112002e-02  1.155003e-02  1.199330e-02  1.245003e-02
## ASV0447      6.778627e-03  7.079901e-03  7.393455e-03  7.719691e-03
## ASV0654      9.198712e-03  9.565275e-03  9.943815e-03  1.033454e-02
## ASV0151      1.652993e-03  1.742995e-03  1.837882e-03  1.937889e-03
## ASV0065     -3.474150e-03 -3.608425e-03 -3.746826e-03 -3.889411e-03
## ASV0527      8.672724e-03  9.015488e-03  9.369395e-03  9.734650e-03
## ASV4055     -1.732564e-03 -1.824443e-03 -1.921565e-03 -2.024253e-03
## ASV0166     -4.053359e-03 -4.197162e-03 -4.344415e-03 -4.495097e-03
## ASV0417     -1.461340e-03 -1.501735e-03 -1.542140e-03 -1.582463e-03
## ASV0078     -2.432574e-03 -2.519426e-03 -2.608256e-03 -2.699022e-03
## ASV0322     -6.924235e-05 -4.479003e-05 -1.690373e-05  1.473363e-05
## ASV0156     -6.530710e-03 -6.811919e-03 -7.104264e-03 -7.408124e-03
## ASV0648     -1.431151e-02 -1.493151e-02 -1.557597e-02 -1.624566e-02
## ASV0407     -1.155662e-03 -1.210697e-03 -1.268345e-03 -1.328726e-03
## ASV2030     -2.261921e-03 -2.360372e-03 -2.463426e-03 -2.571349e-03
## ASV0300      1.803479e-03  1.885935e-03  1.971879e-03  2.061426e-03
## ASV1150      4.913475e-04  5.175065e-04  5.449608e-04  5.737561e-04
## ASV0958      5.662483e-03  5.929534e-03  6.208897e-03  6.501104e-03
## ASV0216     -5.358581e-03 -5.570696e-03 -5.790331e-03 -6.017745e-03
## ASV0446      8.792024e-03  9.169560e-03  9.561545e-03  9.968389e-03
## ASV0367     -5.612392e-03 -5.847023e-03 -6.090314e-03 -6.342506e-03
## ASV0200     -3.315876e-03 -3.452624e-03 -3.594191e-03 -3.740683e-03
## ASV0334     -1.230951e-03 -1.255330e-03 -1.279045e-03 -1.302027e-03
## ASV1311      1.644784e-03  1.684026e-03  1.722485e-03  1.759988e-03
## ASV0458      2.380396e-03  2.436627e-03  2.491963e-03  2.546203e-03
## ASV1371      6.170087e-04  6.462560e-04  6.766757e-04  7.082857e-04
## ASV0418      6.573253e-03  6.804264e-03  7.040800e-03  7.282844e-03
## ASV0004      9.359939e-04  9.678680e-04  1.000419e-03  1.033638e-03
## ASV1943      1.500612e-02  1.537484e-02  1.574176e-02  1.610615e-02
## ASV1495     -2.445270e-03 -2.599441e-03 -2.763286e-03 -2.937356e-03
## ASV0901     -6.641293e-03 -6.939128e-03 -7.249727e-03 -7.573600e-03
## ASV0628      2.714521e-03  2.793749e-03  2.873324e-03  2.953080e-03
## ASV0400      1.812078e-03  1.874419e-03  1.937899e-03  2.002450e-03
## ASV0116     -1.937105e-03 -2.022886e-03 -2.112233e-03 -2.205275e-03
## ASV0788      1.724011e-02  1.800994e-02  1.881228e-02  1.964837e-02
## ASV0117      1.359837e-03  1.424564e-03  1.492234e-03  1.562964e-03
## ASV3137     -3.451871e-04 -3.574218e-04 -3.699180e-04 -3.826655e-04
## ASV0001      9.863275e-04  1.018686e-03  1.051616e-03  1.085095e-03
## ASV1651      2.896986e-03  2.997614e-03  3.100555e-03  3.205798e-03
## ASV1692      1.425685e-02  1.488629e-02  1.554157e-02  1.622361e-02
## ASV0660      3.783232e-03  3.881605e-03  3.978968e-03  4.074964e-03
## ASV0508      1.798648e-04  1.841733e-04  1.884120e-04  1.925622e-04
## ASV1660     -3.248410e-03 -3.407994e-03 -3.574932e-03 -3.749491e-03
## ASV0233      4.186867e-03  4.360480e-03  4.540403e-03  4.726806e-03
## ASV1343     -8.066017e-03 -8.420235e-03 -8.788964e-03 -9.172729e-03
## ASV0209      3.317504e-03  3.427224e-03  3.538908e-03  3.652478e-03
## ASV0193     -3.938768e-03 -4.071724e-03 -4.207150e-03 -4.344940e-03
## ASV0357      2.282212e-03  2.409247e-03  2.543611e-03  2.685719e-03
## ASV0198      3.220807e-03  3.345188e-03  3.473544e-03  3.605965e-03
## ASV0007      8.321874e-04  8.571894e-04  8.824299e-04  9.078757e-04
## ASV1772     -1.049479e-03 -1.062617e-03 -1.073256e-03 -1.081032e-03
## ASV0009      6.533531e-04  6.708822e-04  6.883819e-04  7.058129e-04
## ASV0006     -1.029191e-03 -1.077679e-03 -1.128346e-03 -1.181274e-03
## ASV0011     -3.278743e-03 -3.419709e-03 -3.566172e-03 -3.718304e-03
## ASV0015      4.902125e-04  5.029887e-04  5.156851e-04  5.282652e-04
## ASV0017      5.583076e-04  5.734706e-04  5.886310e-04  6.037567e-04
## ASV0235     -3.069014e-03 -3.202741e-03 -3.341801e-03 -3.486374e-03
## ASV0382      2.346592e-03  2.442306e-03  2.540915e-03  2.642398e-03
## ASV2357      9.867496e-03  1.029285e-02  1.073506e-02  1.119468e-02
## ASV0567     -1.988132e-03 -2.079762e-03 -2.175668e-03 -2.276059e-03
## ASV0165      1.633373e-03  1.702329e-03  1.773821e-03  1.847913e-03
## ASV0005      2.245039e-03  2.333434e-03  2.424625e-03  2.518654e-03
## ASV0384      6.134803e-05  8.149154e-05  1.037824e-04  1.283871e-04
## ASV0002      3.934538e-04  4.079346e-04  4.228418e-04  4.381842e-04
## ASV3017      1.086442e-02  1.123899e-02  1.162161e-02  1.201213e-02
## ASV0091     -3.028617e-04 -3.158668e-04 -3.294886e-04 -3.437681e-04
## ASV0186     -4.586883e-03 -4.770306e-03 -4.959675e-03 -5.155074e-03
## ASV0370      2.321754e-03  2.409338e-03  2.499479e-03  2.592211e-03
## ASV0018      2.901662e-03  3.017424e-03  3.136982e-03  3.260403e-03
## ASV1377      2.700369e-02  2.797417e-02  2.896894e-02  2.998794e-02
## ASV0019      3.052685e-03  3.175007e-03  3.301390e-03  3.431909e-03
## ASV0023     -2.045713e-03 -2.135090e-03 -2.227988e-03 -2.324511e-03
## ASV2194      3.418070e-03  3.576299e-03  3.741664e-03  3.914466e-03
## ASV1155      1.141564e-02  1.184248e-02  1.228223e-02  1.273516e-02
## ASV0510     -2.631754e-03 -2.705906e-03 -2.780610e-03 -2.855806e-03
## ASV2371     -6.843477e-03 -7.095307e-03 -7.354195e-03 -7.620209e-03
## ASV0024     -2.528680e-03 -2.638294e-03 -2.752176e-03 -2.870451e-03
## ASV2452      6.197393e-03  6.382339e-03  6.568702e-03  6.756182e-03
## ASV2332     -2.014370e-02 -2.091457e-02 -2.170974e-02 -2.252973e-02
## ASV2591      6.868658e-03  7.204051e-03  7.553993e-03  7.918891e-03
## ASV0521      5.138126e-03  5.362127e-03  5.595100e-03  5.837345e-03
## ASV5542      4.861712e-03  5.067843e-03  5.281624e-03  5.503267e-03
## ASV0336     -9.359202e-04 -9.918269e-04 -1.050942e-03 -1.113424e-03
## ASV10102     9.005497e-03  9.390353e-03  9.789688e-03  1.020388e-02
## ASV16823    -1.158321e-02 -1.197464e-02 -1.237475e-02 -1.278351e-02
## ASV3104      5.989853e-02  6.192154e-02  6.398938e-02  6.610184e-02
## ASV0781      9.489428e-03  9.870622e-03  1.026493e-02  1.067270e-02
## ASV10899     7.245404e-03  7.625099e-03  8.024339e-03  8.444031e-03
## ASV11222    -2.037314e-02 -2.106136e-02 -2.176487e-02 -2.248358e-02
## ASV11327    -1.828065e-02 -1.889784e-02 -1.952873e-02 -2.017323e-02
## ASV12458    -2.034902e-02 -2.103567e-02 -2.173753e-02 -2.245452e-02
## ASV1636      1.232738e-02  1.278339e-02  1.325218e-02  1.373387e-02
## ASV1890     -8.543838e-03 -8.791243e-03 -9.041448e-03 -9.294283e-03
## ASV2898      1.658781e-02  1.720439e-02  1.783835e-02  1.848989e-02
## ASV8328      4.669832e-03  4.994271e-03  5.339806e-03  5.707600e-03
## ASV0709     -1.906466e-02 -1.980007e-02 -2.055782e-02 -2.133822e-02
## ASV0856      1.789029e-02  1.869459e-02  1.953223e-02  2.040433e-02
## ASV0909      6.814183e-03  7.201528e-03  7.610344e-03  8.041652e-03
## ASV0937     -1.228003e-02 -1.282420e-02 -1.339153e-02 -1.398298e-02
## ASV11390    -2.903376e-02 -3.001350e-02 -3.101495e-02 -3.203802e-02
## ASV11966     9.149898e-03  9.576913e-03  1.002234e-02  1.048681e-02
## ASV12990     5.291676e-03  5.478296e-03  5.669433e-03  5.865098e-03
## ASV14797     7.697572e-03  7.964015e-03  8.236665e-03  8.515517e-03
## ASV14904    -4.166090e-02 -4.306691e-02 -4.450411e-02 -4.597237e-02
## ASV15304     6.179067e-03  6.486122e-03  6.807432e-03  7.143517e-03
## ASV16696    -1.439003e-02 -1.487563e-02 -1.537201e-02 -1.587912e-02
## ASV1690      3.029480e-02  3.163364e-02  3.302454e-02  3.446883e-02
## ASV2029      1.868793e-02  1.941312e-02  2.016135e-02  2.093308e-02
## ASV2834      2.498352e-02  2.603083e-02  2.711629e-02  2.824082e-02
## ASV4003      2.321128e-02  2.434077e-02  2.552496e-02  2.676641e-02
## ASV4064      1.203904e-02  1.255246e-02  1.308523e-02  1.363789e-02
## ASV4294      8.670380e-03  9.114729e-03  9.581481e-03  1.007167e-02
## ASV4609      6.241616e-03  6.481082e-03  6.728310e-03  6.983518e-03
## ASV6283     -1.346272e-02 -1.391781e-02 -1.438309e-02 -1.485852e-02
## ASV6491     -1.928483e-02 -1.993637e-02 -2.060248e-02 -2.128310e-02
## ASV7453      1.228235e-02  1.286241e-02  1.346793e-02  1.409981e-02
## ASV7959      5.362479e-03  5.660134e-03  5.973860e-03  6.304422e-03
## ASV8219      1.666546e-01  1.722873e-01  1.780463e-01  1.839311e-01
## ASV8547     -1.725476e-02 -1.783763e-02 -1.843355e-02 -1.904246e-02
## ASV9319      9.335032e-03  9.755001e-03  1.019280e-02  1.064911e-02
## ASV9382     -3.375385e-02 -3.489408e-02 -3.605986e-02 -3.725111e-02
## ASV11516    -2.253151e-02 -2.329223e-02 -2.406996e-02 -2.486466e-02
## ASV14377    -1.625934e-02 -1.680799e-02 -1.736890e-02 -1.794202e-02
## ASV1867      1.511738e-02  1.576864e-02  1.644531e-02  1.714819e-02
## ASV1895      5.997319e-03  6.168356e-03  6.339564e-03  6.510533e-03
## ASV3168      8.070689e-03  8.339263e-03  8.612711e-03  8.890863e-03
## ASV4449      4.994852e-02  5.198455e-02  5.409410e-02  5.627933e-02
## ASV6596      1.247857e-02  1.309857e-02  1.374896e-02  1.443112e-02
## ASV7492     -5.381483e-05  3.700968e-05  1.372644e-04  2.475438e-04
## ASV9854     -3.387101e-03 -3.498341e-03 -3.611958e-03 -3.727938e-03
## ASV6296      2.726844e-01  2.818832e-01  2.912875e-01  3.008967e-01
## ASV4201      3.524701e-03  3.775351e-03  4.042667e-03  4.327602e-03
## ASV0552      1.034188e-02  1.077986e-02  1.123416e-02  1.170521e-02
## ASV3671     -6.557337e-03 -6.829674e-03 -7.113097e-03 -7.408112e-03
## ASV3529     -3.396169e-04 -2.896381e-04 -2.343217e-04 -1.734108e-04
## ASV1060      2.990112e-03  3.132409e-03  3.281517e-03  3.437766e-03
## ASV0239     -3.003907e-03 -3.096145e-03 -3.189603e-03 -3.284200e-03
## ASV5711     -1.545753e-02 -1.605108e-02 -1.666349e-02 -1.729517e-02
## ASV4152     -2.326283e-02 -2.422521e-02 -2.522244e-02 -2.625541e-02
## ASV1461      9.843271e-03  1.015204e-02  1.046526e-02  1.078265e-02
## ASV2877      5.239066e-03  5.409166e-03  5.581992e-03  5.757396e-03
## ASV0012      1.041304e-03  1.083945e-03  1.128118e-03  1.173865e-03
## ASV9823      7.552998e-04  7.433855e-04  7.275150e-04  7.073129e-04
## ASV0008      1.095202e-03  1.139332e-03  1.185007e-03  1.232269e-03
## ASV7832     -1.396738e-02 -1.456444e-02 -1.518492e-02 -1.582959e-02
## ASV1915     -1.632659e-03 -1.699578e-03 -1.769366e-03 -1.842175e-03
## ASV0055     -1.493137e-03 -1.570098e-03 -1.650971e-03 -1.735936e-03
## ASV0032      3.766445e-04  3.829893e-04  3.889670e-04  3.945404e-04
## ASV2977     -1.911334e-02 -1.989307e-02 -2.070011e-02 -2.153509e-02
## ASV0466      1.306828e-02  1.347977e-02  1.389705e-02  1.431971e-02
## ASV3866      1.119431e-02  1.169022e-02  1.220679e-02  1.274479e-02
## ASV0040      3.879893e-03  4.042718e-03  4.211604e-03  4.386720e-03
## ASV0496     -1.853638e-03 -1.979795e-03 -2.113993e-03 -2.256652e-03
## ASV0052      3.265790e-03  3.403237e-03  3.545838e-03  3.693745e-03
## ASV3828     -9.585547e-03 -9.904659e-03 -1.023055e-02 -1.056317e-02
## ASV1930      5.158172e-03  5.336807e-03  5.519134e-03  5.705056e-03
## ASV2126      9.353939e-03  9.718145e-03  1.009410e-02  1.048205e-02
## ASV0793      1.250837e-02  1.305034e-02  1.361362e-02  1.419888e-02
## ASV0299     -3.437893e-04 -3.679954e-04 -3.942996e-04 -4.228980e-04
## ASV0208      8.796384e-03  9.167783e-03  9.553396e-03  9.953685e-03
## ASV0511     -2.895928e-03 -2.980902e-03 -3.066693e-03 -3.153222e-03
## ASV1123     -9.083462e-03 -9.372501e-03 -9.666269e-03 -9.964575e-03
## ASV0099      4.643576e-04  4.923993e-04  5.222457e-04  5.540118e-04
## ASV0752     -6.768406e-03 -7.079045e-03 -7.403160e-03 -7.741261e-03
## ASV0883      9.172755e-03  9.586214e-03  1.001678e-02  1.046500e-02
## ASV0683      1.175881e-02  1.228033e-02  1.282326e-02  1.338831e-02
## ASV4117     -1.794102e-02 -1.870503e-02 -1.949898e-02 -2.032392e-02
## ASV2172      7.018858e-04  7.059863e-04  7.082969e-04  7.086294e-04
## ASV0330     -3.409853e-03 -3.557397e-03 -3.710850e-03 -3.870421e-03
## ASV0728      1.595069e-02  1.658812e-02  1.724677e-02  1.792711e-02
## ASV0499      4.630284e-03  4.839051e-03  5.056672e-03  5.283471e-03
## ASV0120     -7.105474e-03 -7.390057e-03 -7.683995e-03 -7.987445e-03
## ASV1446      3.837038e-03  3.906514e-03  3.972109e-03  4.033297e-03
## ASV17171    -1.383297e-02 -1.440589e-02 -1.500043e-02 -1.561731e-02
## ASV0533      1.225587e-03  1.286049e-03  1.349391e-03  1.415734e-03
## ASV2495     -4.421326e-03 -4.661251e-03 -4.914241e-03 -5.180933e-03
## ASV5582      4.889501e-03  5.010811e-03  5.130971e-03  5.249630e-03
## ASV1488      2.175253e-03  2.247093e-03  2.319924e-03  2.393635e-03
## ASV0682      3.409303e-03  3.564188e-03  3.725644e-03  3.893901e-03
## ASV0068     -5.444092e-03 -5.665242e-03 -5.893831e-03 -6.129984e-03
## ASV1987     -1.503275e-02 -1.572716e-02 -1.645180e-02 -1.720780e-02
## ASV0035     -1.675360e-03 -1.783991e-03 -1.899867e-03 -2.023449e-03
## ASV7192     -7.946935e-03 -8.247827e-03 -8.557583e-03 -8.876297e-03
## ASV0873     -1.088581e-02 -1.180573e-02 -1.278729e-02 -1.383340e-02
## ASV4749     -2.194032e-03 -2.387673e-03 -2.595778e-03 -2.819205e-03
## ASV2174      4.600438e-03  4.721223e-03  4.841348e-03  4.960475e-03
## ASV1476     -6.599433e-03 -6.905565e-03 -7.225492e-03 -7.559779e-03
## ASV0740     -1.847266e-02 -1.930971e-02 -2.018277e-02 -2.109325e-02
## ASV0170     -3.372024e-03 -3.512376e-03 -3.657913e-03 -3.808787e-03
## ASV2466     -1.547563e-02 -1.612903e-02 -1.680753e-02 -1.751193e-02
## ASV1709      5.279234e-03  5.492114e-03  5.713680e-03  5.944390e-03
## ASV6170     -2.513815e-02 -2.624169e-02 -2.739003e-02 -2.858471e-02
## ASV3673      1.264973e-02  1.322036e-02  1.381515e-02  1.443499e-02
## ASV1745     -3.570002e-03 -3.745842e-03 -3.930119e-03 -4.123192e-03
##                                                                    
## (Intercept)  9.525487e-02  9.903507e-02  1.025671e-01  1.065688e-01
## ASV1236      1.712066e-02  1.772944e-02  1.815710e-02  1.880074e-02
## ASV0421      3.251174e-03  3.432564e-03  3.637516e-03  3.845996e-03
## ASV0691     -1.088519e-02 -1.115595e-02 -1.123820e-02 -1.148704e-02
## ASV0899      1.481753e-02  1.533193e-02  1.568120e-02  1.621314e-02
## ASV1004      3.439079e-02  3.560909e-02  3.649733e-02  3.775270e-02
## ASV1041     -1.368386e-02 -1.413113e-02 -1.440330e-02 -1.486602e-02
## ASV1058      2.143229e-02  2.219406e-02  2.277125e-02  2.355716e-02
## ASV12542     7.842815e-03  8.100627e-03  8.269763e-03  8.524950e-03
## ASV1294      2.003056e-02  2.074731e-02  2.129467e-02  2.204082e-02
## ASV13113     8.475422e-03  8.877392e-03  9.303974e-03  9.740943e-03
## ASV1318      1.987409e-02  2.057704e-02  2.109905e-02  2.183457e-02
## ASV2269     -3.389187e-02 -3.505107e-02 -3.586870e-02 -3.714705e-02
## ASV2542      1.949071e-02  2.033096e-02  2.115084e-02  2.206055e-02
## ASV2660     -1.332865e-02 -1.377960e-02 -1.411446e-02 -1.459854e-02
## ASV2737      4.190523e-03  4.316220e-03  4.372582e-03  4.485089e-03
## ASV2840      1.652878e-02  1.702048e-02  1.730130e-02  1.778906e-02
## ASV3053      8.879271e-02  9.172868e-02  9.397902e-02  9.698490e-02
## ASV3077      5.759726e-03  5.957033e-03  6.116489e-03  6.313645e-03
## ASV3134      1.301931e-02  1.361446e-02  1.422565e-02  1.487049e-02
## ASV3140      1.582882e-02  1.646007e-02  1.701710e-02  1.769687e-02
## ASV3579      6.916729e-03  7.259687e-03  7.627913e-03  7.997102e-03
## ASV6119     -9.271446e-03 -9.588623e-03 -9.821752e-03 -1.016471e-02
## ASV7557     -1.882698e-02 -1.947052e-02 -1.996183e-02 -2.065628e-02
## ASV8422      4.581944e-03  4.737759e-03  4.831795e-03  4.984399e-03
## ASV1086     -5.773558e-04 -5.921963e-04 -6.069078e-04 -6.168300e-04
## ASV1310      9.108326e-03  9.426178e-03  9.658074e-03  9.983851e-03
## ASV15750    -1.011325e-03 -1.033579e-03 -1.041895e-03 -1.067163e-03
## ASV16905    -3.871679e-03 -4.004060e-03 -4.106224e-03 -4.247242e-03
## ASV2033      1.991931e-02  2.078405e-02  2.160329e-02  2.252576e-02
## ASV2089      8.184669e-03  8.465372e-03  8.678170e-03  8.976261e-03
## ASV2127      2.686410e-02  2.781126e-02  2.853885e-02  2.951967e-02
## ASV2725      2.061333e-02  2.129555e-02  2.175515e-02  2.244912e-02
## ASV2804     -8.013954e-03 -8.288077e-03 -8.502009e-03 -8.792133e-03
## ASV3075      1.954246e-02  2.033858e-02  2.107126e-02  2.192056e-02
## ASV3327      2.833445e-02  2.952550e-02  3.061236e-02  3.187836e-02
## ASV3342      2.401521e-02  2.501411e-02  2.594290e-02  2.701423e-02
## ASV3532     -2.580254e-02 -2.684939e-02 -2.784538e-02 -2.897564e-02
## ASV3600      1.211778e-02  1.261298e-02  1.306008e-02  1.358509e-02
## ASV4013      2.119660e-02  2.198999e-02  2.264382e-02  2.347160e-02
## ASV4136      2.100825e-02  2.172772e-02  2.226751e-02  2.301512e-02
## ASV4195      8.174996e-02  8.454481e-02  8.681081e-02  8.975243e-02
## ASV4407     -3.156210e-02 -3.264025e-02 -3.354423e-02 -3.467877e-02
## ASV4717      4.758713e-03  4.892260e-03  4.913121e-03  5.038141e-03
## ASV6794      1.243366e-02  1.284102e-02  1.310133e-02  1.351576e-02
## ASV8324     -1.619462e-02 -1.674777e-02 -1.721519e-02 -1.779418e-02
## ASV8981      2.364035e-04  2.803625e-04  3.375010e-04  3.885556e-04
## ASV9859      8.214033e-03  8.647214e-03  9.131553e-03  9.612500e-03
## ASV0936      1.800430e-02  1.873855e-02  1.941033e-02  2.019047e-02
## ASV12683    -1.661236e-04 -1.765792e-04 -2.094692e-04 -2.226930e-04
## ASV1293      1.049818e-02  1.085930e-02  1.113486e-02  1.150790e-02
## ASV13055     2.157363e-04  2.488564e-04  2.675011e-04  3.035206e-04
## ASV17063    -8.384334e-03 -8.670317e-03 -8.935644e-03 -9.234662e-03
## ASV2228      6.832511e-03  7.065370e-03  7.287828e-03  7.531418e-03
## ASV2769      1.721247e-03  1.812256e-03  1.882568e-03  1.979520e-03
## ASV2803      6.797326e-03  7.003806e-03  7.107914e-03  7.314442e-03
## ASV2896      7.122502e-03  7.438975e-03  7.749563e-03  8.093070e-03
## ASV3062      9.468577e-03  9.918269e-03  1.035767e-02  1.084487e-02
## ASV3107      1.282959e-02  1.337124e-02  1.388147e-02  1.446205e-02
## ASV3265      1.489272e-02  1.539798e-02  1.578549e-02  1.630565e-02
## ASV3666      4.759918e-05  4.282259e-05  3.331818e-06 -4.950790e-06
## ASV4497      5.320660e-03  5.512309e-03  5.650458e-03  5.849393e-03
## ASV6914     -1.199162e-03 -1.262566e-03 -1.350414e-03 -1.420499e-03
## ASV0576     -1.605214e-02 -1.651765e-02 -1.677822e-02 -1.724503e-02
## ASV0673      2.089783e-02  2.166894e-02  2.231712e-02  2.312310e-02
## ASV0772      9.992190e-03  1.037950e-02  1.071988e-02  1.112976e-02
## ASV0862      2.590917e-03  2.765116e-03  2.962592e-03  3.154491e-03
## ASV0898      8.775405e-03  9.158647e-03  9.524156e-03  9.933443e-03
## ASV0910      9.730582e-03  1.014485e-02  1.054491e-02  1.098952e-02
## ASV0964     -6.258629e-03 -6.448087e-03 -6.573058e-03 -6.766363e-03
## ASV10059     7.526864e-03  7.874779e-03  8.224740e-03  8.602575e-03
## ASV10263    -1.282845e-02 -1.326936e-02 -1.360582e-02 -1.405668e-02
## ASV1088      1.708690e-02  1.781128e-02  1.850589e-02  1.928470e-02
## ASV1101      1.819466e-02  1.881400e-02  1.928340e-02  1.992094e-02
## ASV1183      5.404361e-03  5.621548e-03  5.821764e-03  6.051942e-03
## ASV11956     4.164082e-03  4.285620e-03  4.344391e-03  4.467358e-03
## ASV12774    -2.462744e-04 -2.816531e-04 -3.411529e-04 -3.821591e-04
## ASV1321      2.561645e-02  2.672627e-02  2.782054e-02  2.901492e-02
## ASV13793    -8.840326e-03 -9.143861e-03 -9.381789e-03 -9.692823e-03
## ASV14482     4.526368e-04  4.661990e-04  4.781378e-04  4.941653e-04
## ASV15483     4.206535e-03  4.381007e-03  4.537546e-03  4.723306e-03
## ASV2062      1.796189e-02  1.863953e-02  1.924336e-02  1.995760e-02
## ASV2132      1.591131e-02  1.656935e-02  1.717025e-02  1.787064e-02
## ASV2413      1.337883e-02  1.385984e-02  1.428030e-02  1.478497e-02
## ASV2490      3.847153e-02  3.971635e-02  4.062914e-02  4.190459e-02
## ASV2594      5.770000e-03  6.014646e-03  6.269025e-03  6.535378e-03
## ASV2822     -2.337922e-02 -2.418513e-02 -2.475262e-02 -2.557368e-02
## ASV2863      2.445917e-02  2.529616e-02  2.599239e-02  2.686091e-02
## ASV2910      9.094648e-03  9.410775e-03  9.652534e-03  9.980326e-03
## ASV2980      1.078221e-02  1.118842e-02  1.152490e-02  1.194874e-02
## ASV3307      1.857466e-02  1.921367e-02  1.969874e-02  2.035292e-02
## ASV3474      1.502879e-02  1.569540e-02  1.636572e-02  1.708557e-02
## ASV3502      1.421986e-02  1.478439e-02  1.529806e-02  1.589759e-02
## ASV4236      1.764765e-02  1.819081e-02  1.866541e-02  1.922413e-02
## ASV4842     -2.289731e-03 -2.372600e-03 -2.365212e-03 -2.440499e-03
## ASV4894     -8.860693e-03 -9.166299e-03 -9.382180e-03 -9.693896e-03
## ASV5290      7.974044e-03  8.298090e-03  8.584640e-03  8.928268e-03
## ASV5501      4.859722e-03  5.065100e-03  5.307198e-03  5.534169e-03
## ASV5795      5.415861e-03  5.639113e-03  5.862432e-03  6.101998e-03
## ASV5987     -2.477451e-02 -2.563068e-02 -2.620383e-02 -2.707467e-02
## ASV6267     -2.789552e-02 -2.885873e-02 -2.952849e-02 -3.050991e-02
## ASV6862      1.074099e-02  1.109599e-02  1.137716e-02  1.174498e-02
## ASV7145      4.643443e-03  4.798795e-03  4.985281e-03  5.154770e-03
## ASV7673     -8.861772e-03 -9.167699e-03 -9.382725e-03 -9.694404e-03
## ASV7789      6.192831e-03  6.506903e-03  6.871138e-03  7.220169e-03
## ASV7809      9.318308e-04  9.962712e-04  1.086677e-03  1.161276e-03
## ASV8002     -1.119720e-02 -1.158434e-02 -1.185093e-02 -1.224427e-02
## ASV8205      5.299694e-03  5.517261e-03  5.719439e-03  5.952783e-03
## ASV9155     -2.660879e-03 -2.742909e-03 -2.781893e-03 -2.861509e-03
## ASV9221      2.340655e-03  2.486840e-03  2.670832e-03  2.838199e-03
## ASV9311     -1.796384e-02 -1.858550e-02 -1.901425e-02 -1.964384e-02
## ASV9557     -1.226796e-02 -1.269214e-02 -1.299605e-02 -1.342608e-02
## ASV9936     -2.472193e-02 -2.557600e-02 -2.621092e-02 -2.707753e-02
## ASV1445      1.693455e-02  1.762184e-02  1.826809e-02  1.900097e-02
## ASV4232      7.364704e-03  7.719402e-03  8.106524e-03  8.498886e-03
## ASV6479      3.708568e-03  3.929927e-03  4.205556e-03  4.458471e-03
## ASV0142     -1.050724e-02 -1.086562e-02 -1.116097e-02 -1.153340e-02
## ASV0378      6.134127e-03  6.414191e-03  6.672874e-03  6.972242e-03
## ASV1122      1.671472e-02  1.741016e-02  1.808351e-02  1.882934e-02
## ASV0123     -9.224341e-03 -9.535951e-03 -9.797713e-03 -1.012159e-02
## ASV2064      4.050554e-03  4.147375e-03  4.205224e-03  4.299537e-03
## ASV4459     -4.624729e-04 -4.717406e-04 -4.473748e-04 -4.515438e-04
## ASV0448      4.923397e-03  5.149779e-03  5.359202e-03  5.601616e-03
## ASV0397      9.236235e-03  9.591633e-03  9.887584e-03  1.025940e-02
## ASV0485      1.039380e-02  1.077972e-02  1.110836e-02  1.151212e-02
## ASV1566      1.568635e-02  1.628388e-02  1.681501e-02  1.744557e-02
## ASV1365      1.376059e-02  1.429733e-02  1.478175e-02  1.534873e-02
## ASV1065      1.957259e-02  2.034582e-02  2.105949e-02  2.187827e-02
## ASV0722     -1.177151e-03 -1.233918e-03 -1.295550e-03 -1.360053e-03
## ASV12660    -9.930963e-03 -1.026477e-02 -1.050184e-02 -1.083976e-02
## ASV0223      2.925429e-03  3.037860e-03  3.134021e-03  3.251617e-03
## ASV0229      4.868472e-03  5.074972e-03  5.269232e-03  5.489375e-03
## ASV0877      1.278595e-03  1.287875e-03  1.226947e-03  1.225300e-03
## ASV0983      1.009795e-02  1.045912e-02  1.075938e-02  1.113458e-02
## ASV0626      2.179642e-03  2.310408e-03  2.427955e-03  2.571381e-03
## ASV4146      3.206005e-04  3.131279e-04  2.657284e-04  2.512078e-04
## ASV4175     -1.383857e-02 -1.440627e-02 -1.494789e-02 -1.554969e-02
## ASV2082     -8.575247e-03 -9.048886e-03 -9.560938e-03 -1.009096e-02
## ASV2272      6.571052e-03  6.843676e-03  7.111293e-03  7.405555e-03
## ASV2245     -1.001829e-02 -1.043507e-02 -1.083985e-02 -1.128230e-02
## ASV0590     -8.620467e-03 -9.110354e-03 -9.658983e-03 -1.020861e-02
## ASV0217      2.012950e-03  2.163564e-03  2.327123e-03  2.495022e-03
## ASV0416      5.400107e-03  5.523467e-03  5.583438e-03  5.698040e-03
## ASV1056      1.005707e-02  1.049129e-02  1.090027e-02  1.136599e-02
## ASV7777     -1.337066e-02 -1.392189e-02 -1.447184e-02 -1.505949e-02
## ASV0455      2.311438e-03  2.400244e-03  2.486246e-03  2.578636e-03
## ASV0604      6.835582e-03  7.140598e-03  7.419977e-03  7.748122e-03
## ASV6100     -9.557321e-03 -9.968641e-03 -1.038789e-02 -1.083033e-02
## ASV11359    -1.961020e-02 -2.039555e-02 -2.116173e-02 -2.199068e-02
## ASV6604      2.973697e-03  3.105061e-03  3.223398e-03  3.364709e-03
## ASV5004     -6.892336e-03 -7.168749e-03 -7.456708e-03 -7.750426e-03
## ASV1483     -2.889351e-03 -3.000101e-03 -3.119154e-03 -3.234128e-03
## ASV9773     -9.046457e-03 -9.423970e-03 -9.809544e-03 -1.021386e-02
## ASV4059      1.197087e-03  1.300964e-03  1.421386e-03  1.543211e-03
## ASV1193      1.035913e-02  1.076188e-02  1.111376e-02  1.153968e-02
## ASV4610     -2.068723e-04 -1.545212e-04 -9.191101e-05 -2.620834e-05
## ASV0742      2.869949e-04  3.557031e-04  4.176021e-04  4.969392e-04
## ASV1502     -1.305082e-03 -1.395271e-03 -1.518738e-03 -1.618682e-03
## ASV0195     -2.328637e-04 -2.640740e-04 -3.020903e-04 -3.398892e-04
## ASV1213      6.035848e-03  6.210515e-03  6.390385e-03  6.567541e-03
## ASV1648     -8.567201e-03 -8.936847e-03 -9.326233e-03 -9.724777e-03
## ASV6984     -8.056659e-03 -8.407014e-03 -8.790172e-03 -9.169784e-03
## ASV0396      6.716407e-05  8.812933e-05  1.170577e-04  1.389396e-04
## ASV4297      9.245031e-03  9.539479e-03  9.735902e-03  1.003679e-02
## ASV2622      1.532892e-02  1.587312e-02  1.633145e-02  1.689998e-02
## ASV3512      8.372379e-03  8.804168e-03  9.254087e-03  9.732447e-03
## ASV2411      1.253433e-02  1.308852e-02  1.365808e-02  1.425541e-02
## ASV2291     -7.658265e-03 -8.095573e-03 -8.512209e-03 -8.998462e-03
## ASV0807      1.520870e-02  1.579207e-02  1.628845e-02  1.689881e-02
## ASV1292      2.819738e-03  2.889622e-03  2.954434e-03  3.022180e-03
## ASV1035      1.282195e-02  1.327101e-02  1.368728e-02  1.415526e-02
## ASV0070      7.146009e-04  7.727571e-04  8.477606e-04  9.139605e-04
## ASV0255      9.587470e-04  9.742329e-04  9.790138e-04  9.896886e-04
## ASV0057     -3.167354e-03 -3.256646e-03 -3.318638e-03 -3.408083e-03
## ASV0077     -4.652460e-04 -4.669181e-04 -4.572430e-04 -4.574880e-04
## ASV0625      7.110154e-03  7.341043e-03  7.540072e-03  7.777840e-03
## ASV2464      4.833377e-02  4.992575e-02  5.133146e-02  5.296261e-02
## ASV1315      1.654676e-02  1.728760e-02  1.802493e-02  1.882631e-02
## ASV2673      1.426357e-02  1.490620e-02  1.553679e-02  1.623105e-02
## ASV2161      6.018699e-03  6.291711e-03  6.561682e-03  6.859197e-03
## ASV0337     -3.201139e-03 -3.334150e-03 -3.451232e-03 -3.593609e-03
## ASV7680     -2.113266e-02 -2.202344e-02 -2.293462e-02 -2.388851e-02
## ASV0611      1.190074e-02  1.240943e-02  1.289578e-02  1.344261e-02
## ASV3118     -1.322547e-02 -1.382641e-02 -1.445974e-02 -1.510766e-02
## ASV1284      2.670466e-04  8.226360e-05 -1.592979e-04 -3.887270e-04
## ASV0889      7.998006e-03  8.296209e-03  8.553831e-03  8.869760e-03
## ASV4649     -4.300022e-03 -4.473971e-03 -4.651917e-03 -4.837063e-03
## ASV1108     -1.033318e-02 -1.082485e-02 -1.135393e-02 -1.188940e-02
## ASV0738      6.597981e-03  6.950637e-03  7.349860e-03  7.740264e-03
## ASV0473     -1.568075e-03 -1.653279e-03 -1.717572e-03 -1.809195e-03
## ASV0598     -3.732238e-03 -3.946823e-03 -4.167435e-03 -4.405683e-03
## ASV0429      5.529016e-03  5.708678e-03  5.848036e-03  6.032279e-03
## ASV1549      1.321795e-02  1.381574e-02  1.442090e-02  1.506824e-02
## ASV1203      8.704202e-03  9.022984e-03  9.327683e-03  9.662220e-03
## ASV4532      1.855547e-04  1.864799e-04  1.791973e-04  1.809914e-04
## ASV0274      1.963387e-03  2.054686e-03  2.144795e-03  2.241334e-03
## ASV0163     -6.165542e-03 -6.369325e-03 -6.555556e-03 -6.768775e-03
## ASV1298      5.485358e-04  5.669446e-04  6.134740e-04  6.362164e-04
## ASV9424     -1.672593e-02 -1.745311e-02 -1.821782e-02 -1.900450e-02
## ASV0412      1.488019e-02  1.541766e-02  1.589055e-02  1.645129e-02
## ASV0284      2.222957e-03  2.256158e-03  2.262600e-03  2.287615e-03
## ASV0620     -4.472626e-03 -4.707223e-03 -4.979101e-03 -5.237599e-03
## ASV0153     -1.760010e-02 -1.838988e-02 -1.913138e-02 -1.998186e-02
## ASV0498      5.730716e-03  5.961780e-03  6.185825e-03  6.429291e-03
## ASV0097      3.470851e-03  3.627989e-03  3.789300e-03  3.958991e-03
## ASV0104     -2.100645e-02 -2.179805e-02 -2.245675e-02 -2.328517e-02
## ASV1282      6.422187e-03  6.617872e-03  6.726427e-03  6.920461e-03
## ASV3883     -7.329743e-03 -7.682007e-03 -8.065353e-03 -8.447824e-03
## ASV0801      3.098927e-03  3.230479e-03  3.389128e-03  3.532184e-03
## ASV1611     -1.533722e-02 -1.601537e-02 -1.672105e-02 -1.745432e-02
## ASV0227     -3.707814e-03 -3.911168e-03 -4.127258e-03 -4.352701e-03
## ASV0833      4.889170e-03  5.088567e-03  5.279055e-03  5.492041e-03
## ASV0718      2.177774e-02  2.266945e-02  2.353761e-02  2.448878e-02
## ASV1139      1.217461e-03  1.190580e-03  1.133753e-03  1.092515e-03
## ASV0766     -3.659327e-03 -3.835335e-03 -4.035478e-03 -4.227175e-03
## ASV2091      1.493002e-02  1.541140e-02  1.577957e-02  1.627245e-02
## ASV1238     -1.720284e-02 -1.797043e-02 -1.882188e-02 -1.965989e-02
## ASV9193     -2.968159e-03 -3.162144e-03 -3.434518e-03 -3.656916e-03
## ASV0290      1.468274e-03  1.495663e-03  1.487377e-03  1.512780e-03
## ASV0231      5.813370e-03  6.018665e-03  6.205832e-03  6.418904e-03
## ASV0185      5.013585e-03  5.279832e-03  5.576384e-03  5.871187e-03
## ASV2330      5.974675e-03  6.155194e-03  6.278483e-03  6.462086e-03
## ASV3119     -4.443288e-03 -4.674632e-03 -4.931899e-03 -5.187163e-03
## ASV2368     -9.345460e-03 -9.785552e-03 -1.027773e-02 -1.076173e-02
## ASV0122     -3.743573e-03 -3.883948e-03 -3.994506e-03 -4.141807e-03
## ASV1044      1.107463e-02  1.156625e-02  1.205751e-02  1.258929e-02
## ASV0160     -3.522363e-03 -3.632272e-03 -3.719670e-03 -3.833106e-03
## ASV0326      1.132262e-03  1.176324e-03  1.205476e-03  1.250817e-03
## ASV1388      1.953761e-02  2.027026e-02  2.089646e-02  2.166448e-02
## ASV0792      1.354458e-02  1.400722e-02  1.442468e-02  1.490511e-02
## ASV0036     -5.265200e-03 -5.499244e-03 -5.715467e-03 -5.966391e-03
## ASV2125      1.423291e-02  1.477909e-02  1.526401e-02  1.583901e-02
## ASV1075     -2.531911e-04 -2.670538e-04 -2.901311e-04 -3.064887e-04
## ASV0390      8.836870e-03  9.245428e-03  9.684266e-03  1.013063e-02
## ASV3790     -1.157048e-02 -1.205785e-02 -1.255144e-02 -1.307455e-02
## ASV1535     -4.139993e-03 -4.350679e-03 -4.589840e-03 -4.821231e-03
## ASV0263      1.360879e-02  1.415432e-02  1.470458e-02  1.528608e-02
## ASV0675      2.182721e-02  2.277023e-02  2.371219e-02  2.472743e-02
## ASV3348      2.005290e-03  2.101476e-03  2.186237e-03  2.290054e-03
## ASV0058     -5.722532e-03 -5.934024e-03 -6.120247e-03 -6.342016e-03
## ASV4142      7.462501e-03  7.711539e-03  7.922558e-03  8.181255e-03
## ASV0059     -4.512251e-03 -4.674065e-03 -4.817460e-03 -4.986573e-03
## ASV0013     -8.624166e-03 -8.966106e-03 -9.279583e-03 -9.642075e-03
## ASV0033     -4.541943e-03 -4.742826e-03 -4.936638e-03 -5.152673e-03
## ASV4354     -5.207152e-03 -5.424530e-03 -5.647577e-03 -5.881098e-03
## ASV0022     -3.833559e-03 -4.003559e-03 -4.173064e-03 -4.356457e-03
## ASV0134     -4.003614e-03 -4.199374e-03 -4.406296e-03 -4.621787e-03
## ASV0415      7.900379e-04  8.309307e-04  8.823956e-04  9.269026e-04
## ASV10103    -2.065033e-02 -2.154373e-02 -2.250978e-02 -2.347520e-02
## ASV1613      1.280295e-02  1.323345e-02  1.359971e-02  1.404358e-02
## ASV0135     -1.470359e-03 -1.510983e-03 -1.540568e-03 -1.581291e-03
## ASV0469     -1.748226e-02 -1.813627e-02 -1.875719e-02 -1.944964e-02
## ASV0471      1.117666e-02  1.161860e-02  1.204756e-02  1.251886e-02
## ASV0451     -2.887235e-03 -3.051711e-03 -3.218806e-03 -3.400417e-03
## ASV0747      6.566123e-03  6.832768e-03  7.080208e-03  7.363306e-03
## ASV1314     -7.398834e-03 -7.744741e-03 -8.112042e-03 -8.490123e-03
## ASV0425     -2.022126e-02 -2.090089e-02 -2.148556e-02 -2.219122e-02
## ASV0559     -5.691431e-03 -5.927933e-03 -6.158934e-03 -6.415619e-03
## ASV0148     -5.244592e-04 -5.065687e-04 -4.621690e-04 -4.361554e-04
## ASV0129      2.765330e-03  2.949270e-03  3.172131e-03  3.380892e-03
## ASV1072      1.007394e-03  1.020534e-03  1.016020e-03  1.024746e-03
## ASV2390      9.597140e-03  9.870990e-03  1.004576e-02  1.031738e-02
## ASV0548      7.593169e-03  7.886115e-03  8.149991e-03  8.458991e-03
## ASV0168     -3.718343e-03 -3.854455e-03 -3.976360e-03 -4.119500e-03
## ASV0066     -4.244806e-03 -4.400098e-03 -4.533087e-03 -4.694908e-03
## ASV0468     -2.427114e-03 -2.527412e-03 -2.635415e-03 -2.743727e-03
## ASV0172     -8.831935e-04 -8.951668e-04 -8.930899e-04 -9.019131e-04
## ASV0236      1.513856e-03  1.659851e-03  1.846545e-03  2.015411e-03
## ASV0250      7.976814e-03  8.380150e-03  8.820134e-03  9.265157e-03
## ASV0338      3.265006e-03  3.402248e-03  3.535598e-03  3.681144e-03
## ASV0450     -9.607598e-04 -1.019230e-03 -1.080567e-03 -1.146081e-03
## ASV0377      5.276702e-03  5.469220e-03  5.644247e-03  5.845157e-03
## ASV1022     -1.124539e-04 -1.078262e-04 -9.104212e-05 -8.327788e-05
## ASV6174     -3.508479e-04 -3.771189e-04 -4.204155e-04 -4.507797e-04
## ASV0786     -1.451119e-03 -1.537981e-03 -1.632839e-03 -1.729107e-03
## ASV0053     -6.125953e-03 -6.372027e-03 -6.605349e-03 -6.866983e-03
## ASV0697     -3.344128e-03 -3.462875e-03 -3.568861e-03 -3.693823e-03
## ASV0785      7.344014e-03  7.615681e-03  7.862888e-03  8.148413e-03
## ASV1967     -7.220727e-03 -7.488310e-03 -7.726812e-03 -8.008067e-03
## ASV0385      2.939436e-03  3.069499e-03  3.195643e-03  3.334304e-03
## ASV0295      1.028177e-03  1.098065e-03  1.182131e-03  1.261588e-03
## ASV0072     -5.430632e-03 -5.615044e-03 -5.771658e-03 -5.961644e-03
## ASV0157      1.036484e-04  1.534245e-04  2.288012e-04  2.903939e-04
## ASV0501      1.332871e-02  1.386581e-02  1.440087e-02  1.497248e-02
## ASV10729    -1.718000e-02 -1.790002e-02 -1.863403e-02 -1.940692e-02
## ASV1470      6.766934e-03  6.957509e-03  7.098416e-03  7.288066e-03
## ASV0050     -1.351600e-02 -1.401803e-02 -1.447975e-02 -1.500695e-02
## ASV0411     -3.539694e-03 -3.698068e-03 -3.858172e-03 -4.030001e-03
## ASV0549      5.491296e-03  5.725912e-03  5.956697e-03  6.208573e-03
## ASV0184      1.693986e-03  1.762433e-03  1.835873e-03  1.909920e-03
## ASV0705      3.053762e-03  3.156054e-03  3.242525e-03  3.347101e-03
## ASV1715      7.250594e-03  7.540589e-03  7.827247e-03  8.136161e-03
## ASV0603      1.298094e-03  1.362098e-03  1.435630e-03  1.507059e-03
## ASV0826      1.183663e-02  1.229289e-02  1.272394e-02  1.320707e-02
## ASV0034     -3.553963e-03 -3.678025e-03 -3.793267e-03 -3.922536e-03
## ASV0838      5.708046e-04  4.778665e-04  3.588066e-04  2.387338e-04
## ASV0614     -3.229307e-03 -3.353220e-03 -3.469491e-03 -3.600422e-03
## ASV0014     -8.651608e-03 -8.986401e-03 -9.310612e-03 -9.665359e-03
## ASV0585     -4.668957e-04 -5.542833e-04 -6.575159e-04 -7.601435e-04
## ASV0016     -9.037459e-03 -9.387207e-03 -9.734975e-03 -1.010623e-02
## ASV5394     -7.062415e-03 -7.349477e-03 -7.626045e-03 -7.931307e-03
## ASV0666      1.346262e-02  1.392165e-02  1.436141e-02  1.483986e-02
## ASV2085      1.074079e-03  1.002761e-03  9.053973e-04  8.136423e-04
## ASV0003     -6.146604e-03 -6.383826e-03 -6.626556e-03 -6.878823e-03
## ASV0346      3.534279e-03  3.689887e-03  3.839746e-03  4.006125e-03
## ASV0267      4.415001e-04  4.797496e-04  5.190692e-04  5.616942e-04
## ASV0353      5.471627e-03  5.711288e-03  5.960561e-03  6.219484e-03
## ASV2419      1.292039e-02  1.340454e-02  1.388760e-02  1.439957e-02
## ASV0447      8.059020e-03  8.411855e-03  8.772340e-03  9.152784e-03
## ASV0654      1.073763e-02  1.115329e-02  1.155729e-02  1.199732e-02
## ASV0151      2.043261e-03  2.154247e-03  2.264429e-03  2.386701e-03
## ASV0065     -4.036234e-03 -4.187349e-03 -4.330523e-03 -4.489786e-03
## ASV0527      1.011145e-02  1.049999e-02  1.089213e-02  1.130472e-02
## ASV4055     -2.132854e-03 -2.247735e-03 -2.369558e-03 -2.498180e-03
## ASV0166     -4.649183e-03 -4.806639e-03 -4.971761e-03 -5.136929e-03
## ASV0417     -1.622608e-03 -1.662474e-03 -1.693873e-03 -1.732900e-03
## ASV0078     -2.791673e-03 -2.886150e-03 -2.974295e-03 -3.071833e-03
## ASV0322      5.045994e-05  9.063440e-05  1.482541e-04  1.992238e-04
## ASV0156     -7.723888e-03 -8.051953e-03 -8.390132e-03 -8.744242e-03
## ASV0648     -1.694139e-02 -1.766393e-02 -1.840988e-02 -1.918855e-02
## ASV0407     -1.391968e-03 -1.458204e-03 -1.530284e-03 -1.603109e-03
## ASV2030     -2.684422e-03 -2.802945e-03 -2.920294e-03 -3.050939e-03
## ASV0300      2.154694e-03  2.251799e-03  2.349881e-03  2.454712e-03
## ASV1150      6.039373e-04  6.355485e-04  6.666061e-04  7.009467e-04
## ASV0958      6.806707e-03  7.126273e-03  7.461543e-03  7.810771e-03
## ASV0216     -6.253212e-03 -6.497020e-03 -6.756927e-03 -7.019708e-03
## ASV0446      1.039050e-02  1.082829e-02  1.127431e-02  1.174398e-02
## ASV0367     -6.603842e-03 -6.874564e-03 -7.148032e-03 -7.438060e-03
## ASV0200     -3.892202e-03 -4.048847e-03 -4.200882e-03 -4.367471e-03
## ASV0334     -1.324210e-03 -1.345534e-03 -1.373354e-03 -1.393936e-03
## ASV1311      1.796346e-03  1.831364e-03  1.876010e-03  1.908963e-03
## ASV0458      2.599139e-03  2.650549e-03  2.682922e-03  2.730044e-03
## ASV1371      7.411006e-04  7.751312e-04  8.081147e-04  8.442312e-04
## ASV0418      7.530367e-03  7.783334e-03  8.046282e-03  8.310987e-03
## ASV0004      1.067514e-03  1.102034e-03  1.132186e-03  1.167745e-03
## ASV1943      1.646725e-02  1.682428e-02  1.686141e-02  1.719826e-02
## ASV1495     -3.122223e-03 -3.318483e-03 -3.524096e-03 -3.744366e-03
## ASV0901     -7.911274e-03 -8.263297e-03 -8.615362e-03 -8.996710e-03
## ASV0628      3.032838e-03  3.112408e-03  3.190012e-03  3.268820e-03
## ASV0400      2.067994e-03  2.134443e-03  2.197275e-03  2.264941e-03
## ASV0116     -2.302149e-03 -2.402992e-03 -2.505191e-03 -2.614208e-03
## ASV0788      2.051949e-02  2.142696e-02  2.236617e-02  2.335023e-02
## ASV0117      1.636869e-03  1.714070e-03  1.794835e-03  1.878953e-03
## ASV3137     -3.956516e-04 -4.088615e-04 -4.219689e-04 -4.354837e-04
## ASV0001      1.119103e-03  1.153614e-03  1.189410e-03  1.225107e-03
## ASV1651      3.313328e-03  3.423126e-03  3.532871e-03  3.647360e-03
## ASV1692      1.693334e-02  1.767171e-02  1.842692e-02  1.922469e-02
## ASV0660      4.169210e-03  4.261296e-03  4.350827e-03  4.437954e-03
## ASV0508      1.966033e-04  2.005132e-04  2.031388e-04  2.066823e-04
## ASV1660     -3.931937e-03 -4.122539e-03 -4.316119e-03 -4.523275e-03
## ASV0233      4.919859e-03  5.119736e-03  5.326441e-03  5.540628e-03
## ASV1343     -9.572067e-03 -9.987531e-03 -1.041361e-02 -1.086278e-02
## ASV0209      3.767849e-03  3.884925e-03  4.000705e-03  4.121178e-03
## ASV0193     -4.484975e-03 -4.627124e-03 -4.783013e-03 -4.930248e-03
## ASV0357      2.836006e-03  2.994931e-03  3.167442e-03  3.345235e-03
## ASV0198      3.742543e-03  3.883373e-03  4.026383e-03  4.176104e-03
## ASV0007      9.334919e-04  9.592418e-04  9.870033e-04  1.013208e-03
## ASV1772     -1.085542e-03 -1.086350e-03 -1.069298e-03 -1.060307e-03
## ASV0009      7.231348e-04  7.403052e-04  7.600107e-04  7.770808e-04
## ASV0006     -1.236548e-03 -1.294255e-03 -1.350772e-03 -1.413325e-03
## ASV0011     -3.876282e-03 -4.040284e-03 -4.209520e-03 -4.386098e-03
## ASV0015      5.406908e-04  5.529213e-04  5.627801e-04  5.745089e-04
## ASV0017      6.188138e-04  6.337668e-04  6.478309e-04  6.625579e-04
## ASV0235     -3.636642e-03 -3.792793e-03 -3.950923e-03 -4.119183e-03
## ASV0382      2.746720e-03  2.853830e-03  2.955071e-03  3.066725e-03
## ASV2357      1.167231e-02  1.216855e-02  1.268619e-02  1.322190e-02
## ASV0567     -2.381157e-03 -2.491197e-03 -2.607888e-03 -2.728737e-03
## ASV0165      1.924666e-03  2.004142e-03  2.085591e-03  2.170679e-03
## ASV0005      2.615557e-03  2.715369e-03  2.816251e-03  2.921915e-03
## ASV0384      1.554821e-04  1.852537e-04  2.205740e-04  2.563361e-04
## ASV0002      4.539706e-04  4.702104e-04  4.839416e-04  5.009354e-04
## ASV3017      1.241039e-02  1.281620e-02  1.321848e-02  1.363914e-02
## ASV0091     -3.587501e-04 -3.744832e-04 -3.890370e-04 -4.063402e-04
## ASV0186     -5.356581e-03 -5.564262e-03 -5.774279e-03 -5.994277e-03
## ASV0370      2.687571e-03  2.785591e-03  2.893227e-03  2.997087e-03
## ASV0018      3.387749e-03  3.519083e-03  3.654706e-03  3.794306e-03
## ASV1377      3.103107e-02  3.209820e-02  3.319316e-02  3.431040e-02
## ASV0019      3.566639e-03  3.705649e-03  3.853345e-03  4.001544e-03
## ASV0023     -2.424762e-03 -2.528844e-03 -2.628121e-03 -2.739531e-03
## ASV2194      4.095020e-03  4.283649e-03  4.480511e-03  4.686306e-03
## ASV1155      1.320152e-02  1.368157e-02  1.406372e-02  1.456721e-02
## ASV0510     -2.931436e-03 -3.007449e-03 -3.131268e-03 -3.211252e-03
## ASV2371     -7.893408e-03 -8.173844e-03 -8.411403e-03 -8.704529e-03
## ASV0024     -2.993243e-03 -3.120676e-03 -3.247501e-03 -3.384252e-03
## ASV2452      6.944456e-03  7.133187e-03  7.339282e-03  7.529792e-03
## ASV2332     -2.337503e-02 -2.424615e-02 -2.505860e-02 -2.598090e-02
## ASV2591      8.299139e-03  8.695124e-03  9.144477e-03  9.572382e-03
## ASV0521      6.089166e-03  6.350876e-03  6.621113e-03  6.903507e-03
## ASV5542      5.732983e-03  5.970988e-03  6.247354e-03  6.503545e-03
## ASV0336     -1.179436e-03 -1.249145e-03 -1.322993e-03 -1.400437e-03
## ASV10102     1.063332e-02  1.107836e-02  1.155028e-02  1.202830e-02
## ASV16823    -1.320086e-02 -1.362675e-02 -1.398246e-02 -1.442471e-02
## ASV3104      6.825865e-02  7.045950e-02  7.234672e-02  7.463621e-02
## ASV0781      1.109427e-02  1.152998e-02  1.198993e-02  1.245584e-02
## ASV10899     8.885110e-03  9.348542e-03  9.853183e-03  1.036381e-02
## ASV11222    -2.321742e-02 -2.396629e-02 -2.460997e-02 -2.538918e-02
## ASV11327    -2.083128e-02 -2.150278e-02 -2.209509e-02 -2.279487e-02
## ASV12458    -2.318656e-02 -2.393353e-02 -2.460931e-02 -2.538889e-02
## ASV1636      1.422861e-02  1.473651e-02  1.527723e-02  1.581204e-02
## ASV1890     -9.549578e-03 -9.807164e-03 -1.000664e-02 -1.027071e-02
## ASV2898      1.915916e-02  1.984631e-02  2.055992e-02  2.128525e-02
## ASV8328      6.098859e-03  6.514830e-03  6.989212e-03  7.457172e-03
## ASV0709     -2.214156e-02 -2.296808e-02 -2.385644e-02 -2.473203e-02
## ASV0856      2.131200e-02  2.225639e-02  2.325025e-02  2.427103e-02
## ASV0909      8.496500e-03  8.975966e-03  9.466323e-03  9.997368e-03
## ASV0937     -1.459952e-02 -1.524216e-02 -1.588618e-02 -1.658351e-02
## ASV11390    -3.308258e-02 -3.414849e-02 -3.512211e-02 -3.623525e-02
## ASV11966     1.097094e-02  1.147535e-02  1.200988e-02  1.255577e-02
## ASV12990     6.065303e-03  6.270058e-03  6.511013e-03  6.725491e-03
## ASV14797     8.800565e-03  9.091800e-03  9.409844e-03  9.714865e-03
## ASV14904    -4.747151e-02 -4.900132e-02 -5.039886e-02 -5.199641e-02
## ASV15304     7.494899e-03  7.862107e-03  8.267538e-03  8.667741e-03
## ASV16696    -1.639691e-02 -1.692530e-02 -1.741378e-02 -1.796565e-02
## ASV1690      3.596780e-02  3.752273e-02  3.910488e-02  4.076953e-02
## ASV2029      2.172875e-02  2.254880e-02  2.341365e-02  2.428610e-02
## ASV2834      2.940534e-02  3.061075e-02  3.186709e-02  3.315896e-02
## ASV4003      2.806781e-02  2.943195e-02  3.088991e-02  3.238797e-02
## ASV4064      1.421099e-02  1.480505e-02  1.543694e-02  1.607538e-02
## ASV4294      1.058635e-02  1.112663e-02  1.170892e-02  1.230333e-02
## ASV4609      7.246936e-03  7.518802e-03  7.905116e-03  8.198645e-03
## ASV6283     -1.534406e-02 -1.583965e-02 -1.627820e-02 -1.679392e-02
## ASV6491     -2.197817e-02 -2.268760e-02 -2.333185e-02 -2.407080e-02
## ASV7453      1.475893e-02  1.544619e-02  1.621564e-02  1.696418e-02
## ASV7959      6.652610e-03  7.019239e-03  7.442102e-03  7.849102e-03
## ASV8219      1.899413e-01  1.960762e-01  2.016406e-01  2.080230e-01
## ASV8547     -1.966433e-02 -2.029909e-02 -2.088964e-02 -2.155057e-02
## ASV9319      1.112464e-02  1.162010e-02  1.215698e-02  1.269557e-02
## ASV9382     -3.846772e-02 -3.970958e-02 -4.087391e-02 -4.216650e-02
## ASV11516    -2.567626e-02 -2.650466e-02 -2.730079e-02 -2.816377e-02
## ASV14377    -1.852731e-02 -1.912471e-02 -1.971286e-02 -2.033571e-02
## ASV1867      1.787810e-02  1.863587e-02  1.943667e-02  2.025399e-02
## ASV1895      6.680825e-03  6.849976e-03  7.035043e-03  7.202571e-03
## ASV3168      9.173534e-03  9.460526e-03  9.769810e-03  1.006663e-02
## ASV4449      5.854245e-02  6.088572e-02  6.328466e-02  6.579648e-02
## ASV6596      1.514649e-02  1.589653e-02  1.669087e-02  1.751515e-02
## ASV7492      3.684613e-04  5.006490e-04  6.475411e-04  8.029424e-04
## ASV9854     -3.846265e-03 -3.966919e-03 -4.071148e-03 -4.195817e-03
## ASV6296      3.107100e-01  3.207264e-01  3.308048e-01  3.412462e-01
## ASV4201      4.631151e-03  4.954351e-03  5.296239e-03  5.661155e-03
## ASV0552      1.219345e-02  1.269929e-02  1.322429e-02  1.376683e-02
## ASV3671     -7.715254e-03 -8.035093e-03 -8.356586e-03 -8.703101e-03
## ASV3529     -1.066517e-04 -3.379473e-05  3.578915e-05  1.204115e-04
## ASV1060      3.601499e-03  3.773078e-03  3.949561e-03  4.137717e-03
## ASV0239     -3.379851e-03 -3.476467e-03 -3.571429e-03 -3.669836e-03
## ASV5711     -1.794650e-02 -1.861787e-02 -1.930860e-02 -2.002165e-02
## ASV4152     -2.732502e-02 -2.843216e-02 -2.956491e-02 -3.074921e-02
## ASV1461      1.110397e-02  1.142891e-02  1.178800e-02  1.212254e-02
## ASV2877      5.935215e-03  6.115272e-03  6.304785e-03  6.489894e-03
## ASV0012      1.221229e-03  1.270254e-03  1.319512e-03  1.371935e-03
## ASV9823      6.823818e-04  6.523018e-04  6.240809e-04  5.831601e-04
## ASV0008      1.281160e-03  1.331724e-03  1.384284e-03  1.438400e-03
## ASV7832     -1.649921e-02 -1.719458e-02 -1.792111e-02 -1.867055e-02
## ASV1915     -1.918167e-03 -1.997513e-03 -2.085949e-03 -2.172914e-03
## ASV0055     -1.825180e-03 -1.918894e-03 -2.017564e-03 -2.120813e-03
## ASV0032      3.996720e-04  4.043248e-04  4.126683e-04  4.166224e-04
## ASV2977     -2.239862e-02 -2.329131e-02 -2.422281e-02 -2.517680e-02
## ASV0466      1.474733e-02  1.517944e-02  1.565501e-02  1.609867e-02
## ASV3866      1.330502e-02  1.388830e-02  1.449855e-02  1.513091e-02
## ASV0040      4.568241e-03  4.756339e-03  4.954200e-03  5.156334e-03
## ASV0496     -2.408202e-03 -2.569084e-03 -2.732209e-03 -2.912323e-03
## ASV0052      3.847113e-03  4.006098e-03  4.176996e-03  4.348242e-03
## ASV3828     -1.090246e-02 -1.124834e-02 -1.163115e-02 -1.199262e-02
## ASV1930      5.894465e-03  6.087243e-03  6.281971e-03  6.481366e-03
## ASV2126      1.088226e-02  1.129499e-02  1.173267e-02  1.217272e-02
## ASV0793      1.480682e-02  1.543813e-02  1.609452e-02  1.677493e-02
## ASV0299     -4.540037e-04 -4.878474e-04 -5.273448e-04 -5.676567e-04
## ASV0208      1.036912e-02  1.080020e-02  1.125386e-02  1.171848e-02
## ASV0511     -3.240414e-03 -3.328194e-03 -3.430194e-03 -3.520421e-03
## ASV1123     -1.026721e-02 -1.057395e-02 -1.091465e-02 -1.123178e-02
## ASV0099      5.878188e-04  6.237942e-04  6.613585e-04  7.019818e-04
## ASV0752     -8.093875e-03 -8.461542e-03 -8.844644e-03 -9.244106e-03
## ASV0883      1.093144e-02  1.141665e-02  1.192310e-02  1.244770e-02
## ASV0683      1.397624e-02  1.458782e-02  1.521512e-02  1.587584e-02
## ASV4117     -2.118087e-02 -2.207092e-02 -2.299792e-02 -2.395785e-02
## ASV2172      7.067843e-04  7.025501e-04  7.008455e-04  6.916369e-04
## ASV0330     -4.036323e-03 -4.208780e-03 -4.388881e-03 -4.575248e-03
## ASV0728      1.862955e-02  1.935455e-02  2.012413e-02  2.089781e-02
## ASV0499      5.519782e-03  5.765944e-03  6.021102e-03  6.287930e-03
## ASV0120     -8.300558e-03 -8.623476e-03 -8.964387e-03 -9.308133e-03
## ASV1446      4.089519e-03  4.140182e-03  4.192423e-03  4.231140e-03
## ASV17171    -1.625727e-02 -1.692107e-02 -1.762411e-02 -1.833935e-02
## ASV0533      1.485197e-03  1.557906e-03  1.629889e-03  1.709115e-03
## ASV2495     -5.461981e-03 -5.758056e-03 -6.059217e-03 -6.386379e-03
## ASV5582      5.366417e-03  5.480942e-03  5.618124e-03  5.729052e-03
## ASV1488      2.468099e-03  2.543177e-03  2.634414e-03  2.711727e-03
## ASV0682      4.069195e-03  4.251762e-03  4.441261e-03  4.639072e-03
## ASV0068     -6.373821e-03 -6.625452e-03 -6.889864e-03 -7.157913e-03
## ASV1987     -1.799630e-02 -1.881847e-02 -1.967504e-02 -2.056814e-02
## ASV0035     -2.155228e-03 -2.295720e-03 -2.441567e-03 -2.600765e-03
## ASV7192     -9.204047e-03 -9.540904e-03 -9.898581e-03 -1.025496e-02
## ASV0873     -1.494698e-02 -1.613102e-02 -1.731816e-02 -1.864684e-02
## ASV4749     -3.058839e-03 -3.315599e-03 -3.568402e-03 -3.860186e-03
## ASV2174      5.078250e-03  5.194298e-03  5.326222e-03  5.439233e-03
## ASV1476     -7.909009e-03 -8.273780e-03 -8.652063e-03 -9.049540e-03
## ASV0740     -2.204257e-02 -2.303222e-02 -2.406110e-02 -2.513592e-02
## ASV0170     -3.965155e-03 -4.127173e-03 -4.297334e-03 -4.471388e-03
## ASV2466     -1.824309e-02 -1.900183e-02 -1.980005e-02 -2.061757e-02
## ASV1709      6.184739e-03  6.435259e-03  6.711975e-03  6.985875e-03
## ASV6170     -2.982730e-02 -3.111940e-02 -3.246558e-02 -3.386199e-02
## ASV3673      1.508077e-02  1.575341e-02  1.645326e-02  1.718244e-02
## ASV1745     -4.325429e-03 -4.537210e-03 -4.753429e-03 -4.985367e-03
##                                                                    
## (Intercept)  1.107001e-01  1.149587e-01  1.193465e-01  1.238652e-01
## ASV1236      1.944708e-02  2.010898e-02  2.078675e-02  2.148047e-02
## ASV0421      4.056658e-03  4.277420e-03  4.508708e-03  4.750829e-03
## ASV0691     -1.174613e-02 -1.200371e-02 -1.225927e-02 -1.251246e-02
## ASV0899      1.675115e-02  1.729977e-02  1.785891e-02  1.842840e-02
## ASV1004      3.904003e-02  4.035700e-02  4.170358e-02  4.307974e-02
## ASV1041     -1.532253e-02 -1.578404e-02 -1.625019e-02 -1.672039e-02
## ASV1058      2.436587e-02  2.519415e-02  2.604205e-02  2.690968e-02
## ASV12542     8.793502e-03  9.067538e-03  9.346954e-03  9.631788e-03
## ASV1294      2.280437e-02  2.358701e-02  2.438896e-02  2.521040e-02
## ASV13113     1.020055e-02  1.068108e-02  1.118335e-02  1.170822e-02
## ASV1318      2.257978e-02  2.334233e-02  2.412240e-02  2.492002e-02
## ASV2269     -3.836815e-02 -3.961164e-02 -4.087844e-02 -4.216805e-02
## ASV2542      2.300082e-02  2.397757e-02  2.499205e-02  2.604549e-02
## ASV2660     -1.507376e-02 -1.555804e-02 -1.605158e-02 -1.655425e-02
## ASV2737      4.611763e-03  4.740495e-03  4.871082e-03  5.003542e-03
## ASV2840      1.828283e-02  1.877992e-02  1.927972e-02  1.978168e-02
## ASV3053      1.000693e-01  1.032148e-01  1.064212e-01  1.096881e-01
## ASV3077      6.522740e-03  6.736883e-03  6.956012e-03  7.180198e-03
## ASV3134      1.554573e-02  1.625020e-02  1.698499e-02  1.775128e-02
## ASV3140      1.838639e-02  1.909745e-02  1.983061e-02  2.058620e-02
## ASV3579      8.389595e-03  8.800242e-03  9.229584e-03  9.678283e-03
## ASV6119     -1.049851e-02 -1.083849e-02 -1.118481e-02 -1.153734e-02
## ASV7557     -2.133448e-02 -2.202528e-02 -2.272898e-02 -2.344526e-02
## ASV8422      5.147483e-03  5.314474e-03  5.485324e-03  5.660106e-03
## ASV1086     -6.323353e-04 -6.482925e-04 -6.646486e-04 -6.814576e-04
## ASV1310      1.031824e-02  1.065981e-02  1.100847e-02  1.136415e-02
## ASV15750    -1.087306e-03 -1.106550e-03 -1.124868e-03 -1.142146e-03
## ASV16905    -4.386627e-03 -4.528637e-03 -4.673296e-03 -4.820542e-03
## ASV2033      2.348632e-02  2.448275e-02  2.551593e-02  2.658678e-02
## ASV2089      9.271320e-03  9.571948e-03  9.878176e-03  1.018986e-02
## ASV2127      3.052422e-02  3.155221e-02  3.260373e-02  3.367881e-02
## ASV2725      2.315829e-02  2.388015e-02  2.461445e-02  2.536094e-02
## ASV2804     -9.080606e-03 -9.374565e-03 -9.674012e-03 -9.978817e-03
## ASV3075      2.280340e-02  2.371885e-02  2.466801e-02  2.565202e-02
## ASV3327      3.319318e-02  3.455482e-02  3.596440e-02  3.742308e-02
## ASV3342      2.811928e-02  2.926384e-02  3.044905e-02  3.167599e-02
## ASV3532     -3.013508e-02 -3.133554e-02 -3.257843e-02 -3.386502e-02
## ASV3600      1.412978e-02  1.469322e-02  1.527585e-02  1.587812e-02
## ASV4013      2.432347e-02  2.519830e-02  2.609626e-02  2.701747e-02
## ASV4136      2.377597e-02  2.455381e-02  2.534873e-02  2.616078e-02
## ASV4195      9.269663e-02  9.569757e-02  9.875460e-02  1.018664e-01
## ASV4407     -3.581630e-02 -3.697583e-02 -3.815706e-02 -3.935946e-02
## ASV4717      5.170278e-03  5.303798e-03  5.438700e-03  5.575027e-03
## ASV6794      1.394234e-02  1.437793e-02  1.482262e-02  1.527655e-02
## ASV8324     -1.837783e-02 -1.897286e-02 -1.957903e-02 -2.019609e-02
## ASV8981      4.453500e-04  5.068552e-04  5.733516e-04  6.451213e-04
## ASV9859      1.012026e-02  1.065486e-02  1.121764e-02  1.181000e-02
## ASV0936      2.099363e-02  2.182272e-02  2.267809e-02  2.356009e-02
## ASV12683    -2.348588e-04 -2.472489e-04 -2.597628e-04 -2.723246e-04
## ASV1293      1.188824e-02  1.227653e-02  1.267268e-02  1.307661e-02
## ASV13055     3.442425e-04  3.881801e-04  4.355635e-04  4.865864e-04
## ASV17063    -9.537540e-03 -9.846423e-03 -1.016110e-02 -1.048145e-02
## ASV2228      7.778433e-03  8.030360e-03  8.287018e-03  8.548300e-03
## ASV2769      2.081492e-03  2.187843e-03  2.298741e-03  2.414281e-03
## ASV2803      7.524655e-03  7.737477e-03  7.952901e-03  8.170860e-03
## ASV2896      8.451551e-03  8.825479e-03  9.215544e-03  9.622435e-03
## ASV3062      1.135394e-02  1.188480e-02  1.243828e-02  1.301509e-02
## ASV3107      1.506458e-02  1.568966e-02  1.633803e-02  1.701040e-02
## ASV3265      1.683645e-02  1.737774e-02  1.792938e-02  1.849123e-02
## ASV3666     -1.383951e-05 -2.376674e-05 -3.470745e-05 -4.671360e-05
## ASV4497      6.053208e-03  6.261993e-03  6.475860e-03  6.694842e-03
## ASV6914     -1.494201e-03 -1.571465e-03 -1.652302e-03 -1.736813e-03
## ASV0576     -1.771506e-02 -1.818874e-02 -1.866579e-02 -1.914584e-02
## ASV0673      2.395098e-02  2.480080e-02  2.567278e-02  2.656714e-02
## ASV0772      1.155266e-02  1.198887e-02  1.243881e-02  1.290279e-02
## ASV0862      3.357721e-03  3.571895e-03  3.797180e-03  4.033868e-03
## ASV0898      1.035849e-02  1.079922e-02  1.125591e-02  1.172892e-02
## ASV0910      1.145088e-02  1.192951e-02  1.242594e-02  1.294068e-02
## ASV0964     -6.960675e-03 -7.156898e-03 -7.355107e-03 -7.555186e-03
## ASV10059     8.996277e-03  9.406588e-03  9.834143e-03  1.027952e-02
## ASV10263    -1.451783e-02 -1.498835e-02 -1.546773e-02 -1.595580e-02
## ASV1088      2.009422e-02  2.093526e-02  2.180892e-02  2.271632e-02
## ASV1101      2.057106e-02  2.123389e-02  2.190930e-02  2.259712e-02
## ASV1183      6.290320e-03  6.536851e-03  6.791653e-03  7.054935e-03
## ASV11956     4.591375e-03  4.716826e-03  4.843837e-03  4.972414e-03
## ASV12774    -4.270711e-04 -4.754047e-04 -5.271814e-04 -5.825447e-04
## ASV1321      3.025477e-02  3.154148e-02  3.287652e-02  3.426116e-02
## ASV13793    -1.001085e-02 -1.033536e-02 -1.066600e-02 -1.100263e-02
## ASV14482     5.103638e-04  5.271762e-04  5.447997e-04  5.633106e-04
## ASV15483     4.915436e-03  5.114059e-03  5.319397e-03  5.531591e-03
## ASV2062      2.069257e-02  2.144899e-02  2.222722e-02  2.302762e-02
## ASV2132      1.859509e-02  1.934439e-02  2.011915e-02  2.091990e-02
## ASV2413      1.530250e-02  1.583351e-02  1.637822e-02  1.693681e-02
## ASV2490      4.320094e-02  4.451928e-02  4.585914e-02  4.722008e-02
## ASV2594      6.812058e-03  7.099932e-03  7.399531e-03  7.711332e-03
## ASV2822     -2.641288e-02 -2.726920e-02 -2.814169e-02 -2.903001e-02
## ASV2863      2.774815e-02  2.865527e-02  2.958200e-02  3.052837e-02
## ASV2910      1.031509e-02  1.065734e-02  1.100717e-02  1.136460e-02
## ASV2980      1.238491e-02  1.283344e-02  1.329424e-02  1.376746e-02
## ASV3307      2.102085e-02  2.170243e-02  2.239686e-02  2.310389e-02
## ASV3474      1.783407e-02  1.861197e-02  1.942027e-02  2.025984e-02
## ASV3502      1.651677e-02  1.715635e-02  1.781687e-02  1.849885e-02
## ASV4236      1.978888e-02  2.036051e-02  2.093881e-02  2.152342e-02
## ASV4842     -2.517229e-03 -2.594493e-03 -2.671742e-03 -2.748735e-03
## ASV4894     -1.001206e-02 -1.033671e-02 -1.066749e-02 -1.100427e-02
## ASV5290      9.283304e-03  9.650049e-03  1.002881e-02  1.041983e-02
## ASV5501      5.770243e-03  6.016191e-03  6.272647e-03  6.540100e-03
## ASV5795      6.349544e-03  6.605479e-03  6.870081e-03  7.143527e-03
## ASV5987     -2.796335e-02 -2.887016e-02 -2.979408e-02 -3.073476e-02
## ASV6267     -3.151138e-02 -3.253327e-02 -3.357443e-02 -3.463449e-02
## ASV6862      1.211974e-02  1.250206e-02  1.289198e-02  1.328952e-02
## ASV7145      5.328021e-03  5.506087e-03  5.689315e-03  5.877892e-03
## ASV7673     -1.001264e-02 -1.033736e-02 -1.066821e-02 -1.100506e-02
## ASV7789      7.586227e-03  7.970060e-03  8.372541e-03  8.794444e-03
## ASV7809      1.239904e-03  1.322918e-03  1.410595e-03  1.503107e-03
## ASV8002     -1.264626e-02 -1.305642e-02 -1.347432e-02 -1.389981e-02
## ASV8205      6.193989e-03  6.443668e-03  6.702140e-03  6.969636e-03
## ASV9155     -2.942225e-03 -3.023585e-03 -3.105356e-03 -3.187428e-03
## ASV9221      3.014810e-03  3.201590e-03  3.399155e-03  3.608008e-03
## ASV9311     -2.028889e-02 -2.094701e-02 -2.161756e-02 -2.230032e-02
## ASV9557     -1.386699e-02 -1.431682e-02 -1.477515e-02 -1.524183e-02
## ASV9936     -2.796681e-02 -2.887407e-02 -2.979848e-02 -3.073976e-02
## ASV1445      1.975807e-02  2.054053e-02  2.134895e-02  2.218388e-02
## ASV4232      8.909965e-03  9.341104e-03  9.793318e-03  1.026763e-02
## ASV6479      4.724408e-03  5.005491e-03  5.302563e-03  5.616395e-03
## ASV0142     -1.191312e-02 -1.230092e-02 -1.269683e-02 -1.310080e-02
## ASV0378      7.284277e-03  7.608634e-03  7.945571e-03  8.295382e-03
## ASV1122      1.960109e-02  2.040039e-02  2.122803e-02  2.208474e-02
## ASV0123     -1.045135e-02 -1.078783e-02 -1.113102e-02 -1.148088e-02
## ASV2064      4.390487e-03  4.478984e-03  4.564712e-03  4.647272e-03
## ASV4459     -4.574447e-04 -4.634875e-04 -4.696388e-04 -4.759826e-04
## ASV0448      5.854910e-03  6.118616e-03  6.393027e-03  6.678463e-03
## ASV0397      1.064297e-02  1.103775e-02  1.144386e-02  1.186142e-02
## ASV0485      1.192757e-02  1.235448e-02  1.279298e-02  1.324321e-02
## ASV1566      1.809350e-02  1.876012e-02  1.944571e-02  2.015053e-02
## ASV1365      1.593145e-02  1.653096e-02  1.714742e-02  1.778093e-02
## ASV1065      2.272321e-02  2.359479e-02  2.449345e-02  2.541967e-02
## ASV0722     -1.426745e-03 -1.496857e-03 -1.570620e-03 -1.648229e-03
## ASV12660    -1.118748e-02 -1.154197e-02 -1.190305e-02 -1.227064e-02
## ASV0223      3.373689e-03  3.499624e-03  3.629497e-03  3.763408e-03
## ASV0229      5.718731e-03  5.956762e-03  6.203719e-03  6.459888e-03
## ASV0877      1.218131e-03  1.205748e-03  1.187644e-03  1.163246e-03
## ASV0983      1.151899e-02  1.191247e-02  1.231499e-02  1.272653e-02
## ASV0626      2.721708e-03  2.879573e-03  3.045240e-03  3.218945e-03
## ASV4146      2.320335e-04  2.088402e-04  1.812255e-04  1.487100e-04
## ASV4175     -1.617382e-02 -1.681900e-02 -1.748562e-02 -1.817408e-02
## ASV2082     -1.064738e-02 -1.123375e-02 -1.185153e-02 -1.250214e-02
## ASV2272      7.709658e-03  8.024998e-03  8.351947e-03  8.690856e-03
## ASV2245     -1.174171e-02 -1.221696e-02 -1.270835e-02 -1.321620e-02
## ASV0590     -1.078590e-02 -1.139447e-02 -1.203580e-02 -1.271136e-02
## ASV0217      2.674254e-03  2.864258e-03  3.065477e-03  3.278370e-03
## ASV0416      5.810643e-03  5.919770e-03  6.024947e-03  6.125704e-03
## ASV1056      1.184813e-02  1.234793e-02  1.286584e-02  1.340225e-02
## ASV7777     -1.567180e-02 -1.630659e-02 -1.696458e-02 -1.764656e-02
## ASV0455      2.674472e-03  2.772872e-03  2.873821e-03  2.977307e-03
## ASV0604      8.088513e-03  8.442224e-03  8.809646e-03  9.191162e-03
## ASV6100     -1.129204e-02 -1.177213e-02 -1.227126e-02 -1.279014e-02
## ASV11359    -2.284993e-02 -2.373610e-02 -2.464954e-02 -2.559060e-02
## ASV6604      3.510662e-03  3.662126e-03  3.819235e-03  3.982108e-03
## ASV5004     -8.056466e-03 -8.373058e-03 -8.700491e-03 -9.039084e-03
## ASV1483     -3.354598e-03 -3.478515e-03 -3.605900e-03 -3.736786e-03
## ASV9773     -1.063460e-02 -1.107084e-02 -1.152306e-02 -1.199175e-02
## ASV4059      1.670754e-03  1.806608e-03  1.951125e-03  2.104648e-03
## ASV1193      1.197783e-02  1.242945e-02  1.289480e-02  1.337413e-02
## ASV4610      4.104675e-05  1.136866e-04  1.918761e-04  2.757430e-04
## ASV0742      5.816009e-04  6.725007e-04  7.698642e-04  8.739038e-04
## ASV1502     -1.726187e-03 -1.839682e-03 -1.959369e-03 -2.085457e-03
## ASV0195     -3.789605e-04 -4.208189e-04 -4.655940e-04 -5.134100e-04
## ASV1213      6.747554e-03  6.928666e-03  7.110672e-03  7.293360e-03
## ASV1648     -1.014139e-02 -1.057492e-02 -1.102604e-02 -1.149546e-02
## ASV6984     -9.566877e-03 -9.980463e-03 -1.041121e-02 -1.085982e-02
## ASV0396      1.630620e-04  1.882548e-04  2.144343e-04  2.415022e-04
## ASV4297      1.034070e-02  1.064908e-02  1.096181e-02  1.127871e-02
## ASV2622      1.748111e-02  1.807632e-02  1.868570e-02  1.930931e-02
## ASV3512      1.023395e-02  1.076105e-02  1.131494e-02  1.189686e-02
## ASV2411      1.487768e-02  1.552440e-02  1.619628e-02  1.689405e-02
## ASV2291     -9.506207e-03 -1.004068e-02 -1.060298e-02 -1.119419e-02
## ASV0807      1.752792e-02  1.817473e-02  1.883940e-02  1.952205e-02
## ASV1292      3.091398e-03  3.160155e-03  3.228368e-03  3.295963e-03
## ASV1035      1.463779e-02  1.513237e-02  1.563916e-02  1.615830e-02
## ASV0070      9.854610e-04  1.061751e-03  1.143076e-03  1.229692e-03
## ASV0255      9.992998e-04  1.006710e-03  1.011663e-03  1.013882e-03
## ASV0057     -3.497011e-03 -3.585906e-03 -3.674603e-03 -3.762930e-03
## ASV0077     -4.559158e-04 -4.532424e-04 -4.494215e-04 -4.444108e-04
## ASV0625      8.019739e-03  8.265614e-03  8.515360e-03  8.768866e-03
## ASV2464      5.464295e-02  5.635528e-02  5.809930e-02  5.987467e-02
## ASV1315      1.965899e-02  2.052508e-02  2.142560e-02  2.236155e-02
## ASV2673      1.695362e-02  1.770566e-02  1.848811e-02  1.930195e-02
## ASV2161      7.168419e-03  7.490882e-03  7.827086e-03  8.177548e-03
## ASV0337     -3.740431e-03 -3.892510e-03 -4.049988e-03 -4.213012e-03
## ASV7680     -2.488032e-02 -2.590832e-02 -2.697352e-02 -2.807691e-02
## ASV0611      1.401002e-02  1.459917e-02  1.521075e-02  1.584548e-02
## ASV3118     -1.578539e-02 -1.649078e-02 -1.722471e-02 -1.798808e-02
## ASV1284     -6.413039e-04 -9.191895e-04 -1.224037e-03 -1.557587e-03
## ASV0889      9.193953e-03  9.527931e-03  9.871939e-03  1.022624e-02
## ASV4649     -5.029555e-03 -5.228663e-03 -5.434571e-03 -5.647460e-03
## ASV1108     -1.245072e-02 -1.303698e-02 -1.364912e-02 -1.428807e-02
## ASV0738      8.152474e-03  8.586056e-03  9.041999e-03  9.521324e-03
## ASV0473     -1.903500e-03 -2.001576e-03 -2.103417e-03 -2.209006e-03
## ASV0598     -4.658219e-03 -4.924958e-03 -5.206615e-03 -5.503919e-03
## ASV0429      6.218174e-03  6.406553e-03  6.597242e-03  6.790060e-03
## ASV1549      1.574198e-02  1.644323e-02  1.717284e-02  1.793169e-02
## ASV1203      1.000577e-02  1.035804e-02  1.071905e-02  1.108883e-02
## ASV4532      1.820653e-04  1.833290e-04  1.848559e-04  1.867322e-04
## ASV0274      2.342313e-03  2.446844e-03  2.554942e-03  2.666609e-03
## ASV0163     -6.985782e-03 -7.207486e-03 -7.433944e-03 -7.665218e-03
## ASV1298      6.613436e-04  6.884556e-04  7.178029e-04  7.496574e-04
## ASV9424     -1.982416e-02 -2.067673e-02 -2.156338e-02 -2.248534e-02
## ASV0412      1.702759e-02  1.761834e-02  1.822365e-02  1.884358e-02
## ASV0284      2.309759e-03  2.327871e-03  2.341557e-03  2.350404e-03
## ASV0620     -5.510039e-03 -5.795811e-03 -6.095452e-03 -6.409508e-03
## ASV0153     -2.086510e-02 -2.178340e-02 -2.273777e-02 -2.372921e-02
## ASV0498      6.680749e-03  6.939450e-03  7.205391e-03  7.478541e-03
## ASV0097      4.136141e-03  4.320526e-03  4.512377e-03  4.711920e-03
## ASV0104     -2.413514e-02 -2.500792e-02 -2.590363e-02 -2.682236e-02
## ASV1282      7.113853e-03  7.307346e-03  7.500452e-03  7.692658e-03
## ASV3883     -8.848147e-03 -9.265421e-03 -9.700138e-03 -1.015278e-02
## ASV0801      3.681664e-03  3.837138e-03  3.998878e-03  4.167157e-03
## ASV1611     -1.821805e-02 -1.901237e-02 -1.983828e-02 -2.069678e-02
## ASV0227     -4.589070e-03 -4.837485e-03 -5.098437e-03 -5.372431e-03
## ASV0833      5.711553e-03  5.938368e-03  6.172628e-03  6.414478e-03
## ASV0718      2.547403e-02  2.649310e-02  2.754680e-02  2.863591e-02
## ASV1139      1.044097e-03  9.877975e-04  9.230894e-04  8.494214e-04
## ASV0766     -4.427854e-03 -4.637057e-03 -4.855047e-03 -5.082073e-03
## ASV2091      1.677117e-02  1.727704e-02  1.778971e-02  1.830882e-02
## ASV1238     -2.053650e-02 -2.145136e-02 -2.240620e-02 -2.340277e-02
## ASV9193     -3.894435e-03 -4.146808e-03 -4.414848e-03 -4.699394e-03
## ASV0290      1.536975e-03  1.560659e-03  1.583869e-03  1.606657e-03
## ASV0231      6.637122e-03  6.859916e-03  7.087197e-03  7.318859e-03
## ASV0185      6.181861e-03  6.508501e-03  6.851826e-03  7.212579e-03
## ASV2330      6.646549e-03  6.833140e-03  7.021761e-03  7.212324e-03
## ASV3119     -5.456008e-03 -5.738258e-03 -6.034499e-03 -6.345325e-03
## ASV2368     -1.126890e-02 -1.179969e-02 -1.235520e-02 -1.293651e-02
## ASV0122     -4.292503e-03 -4.447394e-03 -4.606522e-03 -4.769934e-03
## ASV1044      1.314269e-02  1.371864e-02  1.431792e-02  1.494134e-02
## ASV0160     -3.947752e-03 -4.064315e-03 -4.182798e-03 -4.303215e-03
## ASV0326      1.297119e-03  1.344479e-03  1.392857e-03  1.442209e-03
## ASV1388      2.245221e-02  2.326109e-02  2.409128e-02  2.494288e-02
## ASV0792      1.539513e-02  1.589485e-02  1.640414e-02  1.692282e-02
## ASV0036     -6.226647e-03 -6.496773e-03 -6.776991e-03 -7.067523e-03
## ASV2125      1.642981e-02  1.703733e-02  1.766170e-02  1.830305e-02
## ASV1075     -3.241493e-04 -3.430710e-04 -3.633604e-04 -3.851277e-04
## ASV0390      1.059740e-02  1.108496e-02  1.159416e-02  1.212588e-02
## ASV3790     -1.361780e-02 -1.418105e-02 -1.476489e-02 -1.536990e-02
## ASV1535     -5.064636e-03 -5.319500e-03 -5.586246e-03 -5.865293e-03
## ASV0263      1.588779e-02  1.650927e-02  1.715096e-02  1.781328e-02
## ASV0675      2.578187e-02  2.687664e-02  2.801295e-02  2.919199e-02
## ASV3348      2.398065e-03  2.510672e-03  2.628002e-03  2.750185e-03
## ASV0058     -6.569025e-03 -6.801816e-03 -7.040393e-03 -7.284754e-03
## ASV4142      8.442845e-03  8.709330e-03  8.980649e-03  9.256748e-03
## ASV0059     -5.159220e-03 -5.335842e-03 -5.516411e-03 -5.700893e-03
## ASV0013     -1.001584e-02 -1.040144e-02 -1.079909e-02 -1.120902e-02
## ASV0033     -5.376826e-03 -5.609527e-03 -5.850984e-03 -6.101404e-03
## ASV4354     -6.124431e-03 -6.377003e-03 -6.639128e-03 -6.911116e-03
## ASV0022     -4.546920e-03 -4.744786e-03 -4.950252e-03 -5.163515e-03
## ASV0134     -4.847159e-03 -5.083281e-03 -5.330627e-03 -5.589700e-03
## ASV0415      9.737267e-04  1.022433e-03  1.073060e-03  1.125635e-03
## ASV10103    -2.447986e-02 -2.552313e-02 -2.660620e-02 -2.773023e-02
## ASV1613      1.449403e-02  1.495181e-02  1.541656e-02  1.588789e-02
## ASV0135     -1.621481e-03 -1.661556e-03 -1.701430e-03 -1.741018e-03
## ASV0469     -2.016116e-02 -2.089355e-02 -2.164720e-02 -2.242254e-02
## ASV0471      1.300498e-02  1.350707e-02  1.402552e-02  1.456074e-02
## ASV0451     -3.591376e-03 -3.792218e-03 -4.003314e-03 -4.225043e-03
## ASV0747      7.655257e-03  7.956584e-03  8.267414e-03  8.587873e-03
## ASV1314     -8.885500e-03 -9.298661e-03 -9.730341e-03 -1.018129e-02
## ASV0425     -2.290881e-02 -2.364049e-02 -2.438614e-02 -2.514559e-02
## ASV0559     -6.681706e-03 -6.958683e-03 -7.247021e-03 -7.547227e-03
## ASV0148     -4.053622e-04 -3.700645e-04 -3.299282e-04 -2.846079e-04
## ASV0129      3.603608e-03  3.840173e-03  4.091318e-03  4.357793e-03
## ASV1072      1.031468e-03  1.035926e-03  1.037917e-03  1.037223e-03
## ASV2390      1.058708e-02  1.085611e-02  1.112386e-02  1.138971e-02
## ASV0548      8.776752e-03  9.103746e-03  9.440071e-03  9.785825e-03
## ASV0168     -4.266017e-03 -4.416426e-03 -4.570766e-03 -4.729079e-03
## ASV0066     -4.860292e-03 -5.029506e-03 -5.202498e-03 -5.379204e-03
## ASV0468     -2.856171e-03 -2.972807e-03 -3.093782e-03 -3.219247e-03
## ASV0172     -9.087173e-04 -9.137086e-04 -9.167143e-04 -9.175573e-04
## ASV0236      2.197533e-03  2.392478e-03  2.600907e-03  2.823490e-03
## ASV0250      9.732867e-03  1.022369e-02  1.073868e-02  1.127889e-02
## ASV0338      3.831483e-03  3.986429e-03  4.145990e-03  4.310160e-03
## ASV0450     -1.215220e-03 -1.288387e-03 -1.365780e-03 -1.447609e-03
## ASV0377      6.051090e-03  6.261847e-03  6.477379e-03  6.697617e-03
## ASV1022     -7.397578e-05 -6.308392e-05 -5.043641e-05 -3.585893e-05
## ASV6174     -4.838924e-04 -5.190614e-04 -5.563729e-04 -5.958895e-04
## ASV0786     -1.829921e-03 -1.935753e-03 -2.046734e-03 -2.162997e-03
## ASV0053     -7.136932e-03 -7.415603e-03 -7.703151e-03 -7.999730e-03
## ASV0697     -3.821482e-03 -3.952479e-03 -4.086867e-03 -4.224706e-03
## ASV0785      8.441289e-03  8.741942e-03  9.050438e-03  9.366843e-03
## ASV1967     -8.297664e-03 -8.595412e-03 -8.901437e-03 -9.215853e-03
## ASV0385      3.478233e-03  3.627162e-03  3.781147e-03  3.940226e-03
## ASV0295      1.346356e-03  1.436450e-03  1.532154e-03  1.633758e-03
## ASV0072     -6.154531e-03 -6.350583e-03 -6.549637e-03 -6.751516e-03
## ASV0157      3.584056e-04  4.329286e-04  5.144089e-04  6.033081e-04
## ASV0501      1.556300e-02  1.617210e-02  1.680003e-02  1.744699e-02
## ASV10729    -2.020863e-02 -2.103928e-02 -2.189965e-02 -2.279052e-02
## ASV1470      7.476566e-03  7.664500e-03  7.851414e-03  8.036841e-03
## ASV0050     -1.554758e-02 -1.610224e-02 -1.667095e-02 -1.725373e-02
## ASV0411     -4.208811e-03 -4.395103e-03 -4.589160e-03 -4.791280e-03
## ASV0549      6.469724e-03  6.740486e-03  7.021103e-03  7.311821e-03
## ASV0184      1.986936e-03  2.066947e-03  2.150086e-03  2.236494e-03
## ASV0705      3.453424e-03  3.561204e-03  3.670324e-03  3.780645e-03
## ASV1715      8.454986e-03  8.784054e-03  9.123548e-03  9.473646e-03
## ASV0603      1.582510e-03  1.662091e-03  1.746056e-03  1.834672e-03
## ASV0826      1.370483e-02  1.421764e-02  1.474578e-02  1.528953e-02
## ASV0034     -4.054347e-03 -4.188873e-03 -4.326066e-03 -4.465874e-03
## ASV0838      1.038124e-04 -4.726869e-05 -2.157659e-04 -4.030225e-04
## ASV0614     -3.735411e-03 -3.874401e-03 -4.017461e-03 -4.164651e-03
## ASV0014     -1.003053e-02 -1.040650e-02 -1.079342e-02 -1.119142e-02
## ASV0585     -8.709714e-04 -9.904750e-04 -1.119048e-03 -1.257088e-03
## ASV0016     -1.048848e-02 -1.088207e-02 -1.128717e-02 -1.170391e-02
## ASV5394     -8.246774e-03 -8.572510e-03 -8.908684e-03 -9.255446e-03
## ASV0666      1.532784e-02  1.582559e-02  1.633300e-02  1.684994e-02
## ASV2085      7.092926e-04  5.925433e-04  4.626064e-04  3.186765e-04
## ASV0003     -7.138575e-03 -7.406037e-03 -7.681310e-03 -7.964495e-03
## ASV0346      4.178784e-03  4.357639e-03  4.542802e-03  4.734368e-03
## ASV0267      6.071830e-04  6.552261e-04  7.058663e-04  7.591266e-04
## ASV0353      6.488776e-03  6.768552e-03  7.059128e-03  7.360821e-03
## ASV2419      1.492526e-02  1.546523e-02  1.601953e-02  1.658823e-02
## ASV0447      9.548187e-03  9.958785e-03  1.038502e-02  1.082734e-02
## ASV0654      1.245015e-02  1.291613e-02  1.339537e-02  1.388798e-02
## ASV0151      2.515492e-03  2.650913e-03  2.793244e-03  2.942767e-03
## ASV0065     -4.653240e-03 -4.821123e-03 -4.993465e-03 -5.170299e-03
## ASV0527      1.172938e-02  1.216650e-02  1.261622e-02  1.307869e-02
## ASV4055     -2.634465e-03 -2.778768e-03 -2.931602e-03 -3.093505e-03
## ASV0166     -5.305171e-03 -5.476708e-03 -5.651482e-03 -5.829440e-03
## ASV0417     -1.770892e-03 -1.808146e-03 -1.844528e-03 -1.879906e-03
## ASV0078     -3.170804e-03 -3.271243e-03 -3.373036e-03 -3.476060e-03
## ASV0322      2.555285e-04  3.178971e-04  3.867750e-04  4.626401e-04
## ASV0156     -9.111793e-03 -9.493373e-03 -9.889431e-03 -1.030043e-02
## ASV0648     -1.999656e-02 -2.083468e-02 -2.170376e-02 -2.260464e-02
## ASV0407     -1.679393e-03 -1.759271e-03 -1.842907e-03 -1.930471e-03
## ASV2030     -3.188298e-03 -3.332586e-03 -3.484225e-03 -3.643644e-03
## ASV0300      2.563828e-03  2.677239e-03  2.795061e-03  2.917405e-03
## ASV1150      7.367919e-04  7.741936e-04  8.131780e-04  8.537700e-04
## ASV0958      8.175875e-03  8.557412e-03  8.956053e-03  9.372483e-03
## ASV0216     -7.291491e-03 -7.573029e-03 -7.864698e-03 -8.166901e-03
## ASV0446      1.223056e-02  1.273439e-02  1.325585e-02  1.379533e-02
## ASV0367     -7.737996e-03 -8.048281e-03 -8.369153e-03 -8.700853e-03
## ASV0200     -4.539265e-03 -4.716481e-03 -4.899183e-03 -5.087433e-03
## ASV0334     -1.413383e-03 -1.431867e-03 -1.449367e-03 -1.465870e-03
## ASV1311      1.940155e-03  1.969243e-03  1.995986e-03  2.020127e-03
## ASV0458      2.775175e-03  2.817858e-03  2.857842e-03  2.894861e-03
## ASV1371      8.815603e-04  9.200667e-04  9.597273e-04  1.000517e-03
## ASV0418      8.581071e-03  8.856489e-03  9.137184e-03  9.423084e-03
## ASV0004      1.203770e-03  1.240357e-03  1.277486e-03  1.315136e-03
## ASV1943      1.752517e-02  1.784473e-02  1.815588e-02  1.845777e-02
## ASV1495     -3.977861e-03 -4.225277e-03 -4.487309e-03 -4.764682e-03
## ASV0901     -9.393921e-03 -9.807758e-03 -1.023885e-02 -1.068787e-02
## ASV0628      3.346671e-03  3.423452e-03  3.498899e-03  3.572736e-03
## ASV0400      2.333199e-03  2.401879e-03  2.470833e-03  2.539895e-03
## ASV0116     -2.727553e-03 -2.845434e-03 -2.968003e-03 -3.095419e-03
## ASV0788      2.437513e-02  2.544209e-02  2.655269e-02  2.770850e-02
## ASV0117      1.966827e-03  2.058503e-03  2.154113e-03  2.253789e-03
## ASV3137     -4.492227e-04 -4.630937e-04 -4.770690e-04 -4.911142e-04
## ASV0001      1.261201e-03  1.297717e-03  1.334625e-03  1.371899e-03
## ASV1651      3.763965e-03  3.882780e-03  4.003783e-03  4.126951e-03
## ASV1692      2.005420e-02  2.091638e-02  2.181231e-02  2.274309e-02
## ASV0660      4.521561e-03  4.601212e-03  4.676382e-03  4.746518e-03
## ASV0508      2.099686e-04  2.130041e-04  2.157488e-04  2.181619e-04
## ASV1660     -4.739409e-03 -4.964724e-03 -5.199483e-03 -5.443935e-03
## ASV0233      5.762212e-03  5.991343e-03  6.228203e-03  6.472970e-03
## ASV1343     -1.132985e-02 -1.181540e-02 -1.232009e-02 -1.284456e-02
## ASV0209      4.242920e-03  4.365940e-03  4.490099e-03  4.615250e-03
## ASV0193     -5.079297e-03 -5.229929e-03 -5.381963e-03 -5.535191e-03
## ASV0357      3.533281e-03  3.732022e-03  3.942034e-03  4.163912e-03
## ASV0198      4.330278e-03  4.489115e-03  4.652728e-03  4.821233e-03
## ASV0007      1.039421e-03  1.065635e-03  1.091808e-03  1.117898e-03
## ASV1772     -1.045757e-03 -1.025232e-03 -9.980483e-04 -9.634727e-04
## ASV0009      7.938724e-04  8.103622e-04  8.265039e-04  8.422519e-04
## ASV0006     -1.478580e-03 -1.546610e-03 -1.617508e-03 -1.691366e-03
## ASV0011     -4.569213e-03 -4.759091e-03 -4.955920e-03 -5.159893e-03
## ASV0015      5.858094e-04  5.967330e-04  6.072282e-04  6.172427e-04
## ASV0017      6.769832e-04  6.911514e-04  7.050187e-04  7.185410e-04
## ASV0235     -4.293883e-03 -4.475250e-03 -4.663497e-03 -4.858841e-03
## ASV0382      3.181013e-03  3.297668e-03  3.416542e-03  3.537467e-03
## ASV2357      1.377795e-02  1.435514e-02  1.495412e-02  1.557558e-02
## ASV0567     -2.855340e-03 -2.987965e-03 -3.126917e-03 -3.272512e-03
## ASV0165      2.258710e-03  2.349708e-03  2.443729e-03  2.540829e-03
## ASV0005      3.030538e-03  3.142173e-03  3.256834e-03  3.374533e-03
## ASV0384      2.954901e-04  3.381762e-04  3.846385e-04  4.351312e-04
## ASV0002      5.183528e-04  5.362452e-04  5.546210e-04  5.734892e-04
## ASV3017      1.406620e-02  1.449991e-02  1.493999e-02  1.538614e-02
## ASV0091     -4.245030e-04 -4.436469e-04 -4.638425e-04 -4.851685e-04
## ASV0186     -6.220565e-03 -6.453197e-03 -6.692187e-03 -6.937537e-03
## ASV0370      3.103752e-03  3.213238e-03  3.325585e-03  3.440833e-03
## ASV0018      3.938040e-03  4.085985e-03  4.238185e-03  4.394680e-03
## ASV1377      3.545077e-02  3.661447e-02  3.780117e-02  3.901053e-02
## ASV0019      4.154244e-03  4.311517e-03  4.473420e-03  4.640007e-03
## ASV0023     -2.855046e-03 -2.974755e-03 -3.098753e-03 -3.227133e-03
## ASV2194      4.901196e-03  5.125567e-03  5.359794e-03  5.604269e-03
## ASV1155      1.508516e-02  1.561788e-02  1.616568e-02  1.672889e-02
## ASV0510     -3.291262e-03 -3.371648e-03 -3.452393e-03 -3.533495e-03
## ASV2371     -9.004436e-03 -9.311632e-03 -9.626132e-03 -9.947932e-03
## ASV0024     -3.525991e-03 -3.672844e-03 -3.824926e-03 -3.982353e-03
## ASV2452      7.719630e-03  7.908548e-03  8.096125e-03  8.281929e-03
## ASV2332     -2.692960e-02 -2.790623e-02 -2.891134e-02 -2.994546e-02
## ASV2591      1.001796e-02  1.048049e-02  1.096027e-02  1.145753e-02
## ASV0521      7.196724e-03  7.501128e-03  7.817053e-03  8.144842e-03
## ASV5542      6.768957e-03  7.043534e-03  7.327495e-03  7.621060e-03
## ASV0336     -1.482256e-03 -1.568504e-03 -1.659386e-03 -1.755109e-03
## ASV10102     1.252319e-02  1.303518e-02  1.356462e-02  1.411185e-02
## ASV16823    -1.487366e-02 -1.533095e-02 -1.579651e-02 -1.627026e-02
## ASV3104      7.695910e-02  7.932512e-02  8.173392e-02  8.418507e-02
## ASV0781      1.293710e-02  1.343407e-02  1.394714e-02  1.447673e-02
## ASV10899     1.090046e-02  1.146355e-02  1.205419e-02  1.267350e-02
## ASV11222    -2.617934e-02 -2.698416e-02 -2.780353e-02 -2.863730e-02
## ASV11327    -2.350427e-02 -2.422683e-02 -2.496245e-02 -2.571099e-02
## ASV12458    -2.617900e-02 -2.698376e-02 -2.780306e-02 -2.863675e-02
## ASV1636      1.636094e-02  1.692344e-02  1.749961e-02  1.808952e-02
## ASV1890     -1.053345e-02 -1.079802e-02 -1.106432e-02 -1.133223e-02
## ASV2898      2.202868e-02  2.279072e-02  2.357149e-02  2.437112e-02
## ASV8328      7.955577e-03  8.484012e-03  9.043917e-03  9.636772e-03
## ASV0709     -2.563242e-02 -2.655706e-02 -2.750612e-02 -2.847975e-02
## ASV0856      2.533282e-02  2.643596e-02  2.758159e-02  2.877088e-02
## ASV0909      1.055628e-02  1.114433e-02  1.176272e-02  1.241266e-02
## ASV0937     -1.730944e-02 -1.806583e-02 -1.885388e-02 -1.967484e-02
## ASV11390    -3.736281e-02 -3.851127e-02 -3.968047e-02 -4.087017e-02
## ASV11966     1.312458e-02  1.371610e-02  1.433095e-02  1.496973e-02
## ASV12990     6.945518e-03  7.170171e-03  7.399445e-03  7.633354e-03
## ASV14797     1.002629e-02  1.034396e-02  1.066784e-02  1.099794e-02
## ASV14904    -5.361436e-02 -5.526230e-02 -5.693997e-02 -5.864707e-02
## ASV15304     9.086372e-03  9.522945e-03  9.977977e-03  1.045198e-02
## ASV16696    -1.852466e-02 -1.909404e-02 -1.967368e-02 -2.026348e-02
## ASV1690      4.249565e-02  4.428210e-02  4.612985e-02  4.803985e-02
## ASV2029      2.518426e-02  2.610872e-02  2.705992e-02  2.803828e-02
## ASV2834      3.449406e-02  3.587366e-02  3.729858e-02  3.876958e-02
## ASV4003      3.395934e-02  3.560587e-02  3.733097e-02  3.913821e-02
## ASV4064      1.673691e-02  1.742170e-02  1.813030e-02  1.886328e-02
## ASV4294      1.292768e-02  1.358235e-02  1.426862e-02  1.498779e-02
## ASV4609      8.504303e-03  8.819822e-03  9.145500e-03  9.481659e-03
## ASV6283     -1.731645e-02 -1.784867e-02 -1.839048e-02 -1.894178e-02
## ASV6491     -2.481973e-02 -2.558254e-02 -2.635910e-02 -2.714927e-02
## ASV7453      1.774533e-02  1.855855e-02  1.940474e-02  2.028481e-02
## ASV7959      8.278445e-03  8.729881e-03  9.204362e-03  9.702872e-03
## ASV8219      2.144952e-01  2.210873e-01  2.277983e-01  2.346268e-01
## ASV8547     -2.222106e-02 -2.290397e-02 -2.359920e-02 -2.430660e-02
## ASV9319      1.325698e-02  1.384156e-02  1.445017e-02  1.508368e-02
## ASV9382     -4.347839e-02 -4.481459e-02 -4.617486e-02 -4.755897e-02
## ASV11516    -2.903999e-02 -2.993245e-02 -3.084100e-02 -3.176546e-02
## ASV14377    -2.096839e-02 -2.161279e-02 -2.226880e-02 -2.293630e-02
## ASV1867      2.110199e-02  2.198149e-02  2.289338e-02  2.383860e-02
## ASV1895      7.367171e-03  7.528658e-03  7.686438e-03  7.839899e-03
## ASV3168      1.036736e-02  1.067168e-02  1.097932e-02  1.129003e-02
## ASV4449      6.839356e-02  7.108026e-02  7.385908e-02  7.673257e-02
## ASV6596      1.837910e-02  1.928417e-02  2.023207e-02  2.122457e-02
## ASV7492      9.725018e-04  1.155993e-03  1.354127e-03  1.567628e-03
## ASV9854     -4.321999e-03 -4.450298e-03 -4.580676e-03 -4.713086e-03
## ASV6296      3.518627e-01  3.626760e-01  3.736842e-01  3.848852e-01
## ASV4201      6.049586e-03  6.462230e-03  6.900343e-03  7.365225e-03
## ASV0552      1.432824e-02  1.490891e-02  1.550924e-02  1.612958e-02
## ASV3671     -9.063681e-03 -9.439461e-03 -9.831180e-03 -1.023962e-02
## ASV3529      2.123388e-04  3.113019e-04  4.175133e-04  5.311735e-04
## ASV1060      4.334856e-03  4.541429e-03  4.757888e-03  4.984702e-03
## ASV0239     -3.768638e-03 -3.867978e-03 -3.967738e-03 -4.067795e-03
## ASV5711     -2.075529e-02 -2.151044e-02 -2.228747e-02 -2.308674e-02
## ASV4152     -3.197290e-02 -3.323745e-02 -3.454364e-02 -3.589226e-02
## ASV1461      1.245965e-02  1.279933e-02  1.314125e-02  1.348506e-02
## ASV2877      6.676581e-03  6.864757e-03  7.054181e-03  7.244593e-03
## ASV0012      1.426124e-03  1.482150e-03  1.540057e-03  1.599889e-03
## ASV9823      5.359462e-04  4.817835e-04  4.201440e-04  3.504774e-04
## ASV0008      1.494311e-03  1.552079e-03  1.611748e-03  1.673365e-03
## ASV7832     -1.944786e-02 -2.025408e-02 -2.109001e-02 -2.195647e-02
## ASV1915     -2.263506e-03 -2.358192e-03 -2.457185e-03 -2.560709e-03
## ASV0055     -2.229151e-03 -2.342788e-03 -2.461947e-03 -2.586857e-03
## ASV0032      4.199790e-04  4.227384e-04  4.248695e-04  4.263449e-04
## ASV2977     -2.616116e-02 -2.717694e-02 -2.822467e-02 -2.930480e-02
## ASV0466      1.654526e-02  1.699450e-02  1.744582e-02  1.789858e-02
## ASV3866      1.578895e-02  1.647364e-02  1.718593e-02  1.792681e-02
## ASV0040      5.365582e-03  5.582142e-03  5.806190e-03  6.037904e-03
## ASV0496     -3.103165e-03 -3.305136e-03 -3.518718e-03 -3.744392e-03
## ASV0052      4.525633e-03  4.709342e-03  4.899543e-03  5.096409e-03
## ASV3828     -1.236017e-02 -1.273407e-02 -1.311423e-02 -1.350053e-02
## ASV1930      6.683842e-03  6.889167e-03  7.097174e-03  7.307687e-03
## ASV2126      1.262605e-02  1.309309e-02  1.357412e-02  1.406944e-02
## ASV0793      1.748087e-02  1.821309e-02  1.897232e-02  1.975932e-02
## ASV0299     -6.114082e-04 -6.590091e-04 -7.107911e-04 -7.671096e-04
## ASV0208      1.220023e-02  1.269975e-02  1.321760e-02  1.375434e-02
## ASV0511     -3.611058e-03 -3.702132e-03 -3.793608e-03 -3.885453e-03
## ASV1123     -1.155217e-02 -1.187575e-02 -1.220223e-02 -1.253126e-02
## ASV0099      7.451395e-04  7.910201e-04  8.397806e-04  8.915851e-04
## ASV0752     -9.660411e-03 -1.009409e-02 -1.054577e-02 -1.101607e-02
## ASV0883      1.299286e-02  1.355905e-02  1.414680e-02  1.475666e-02
## ASV0683      1.656246e-02  1.727587e-02  1.801688e-02  1.878634e-02
## ASV4117     -2.495390e-02 -2.598754e-02 -2.705995e-02 -2.817235e-02
## ASV2172      6.794826e-04  6.640228e-04  6.449860e-04  6.220860e-04
## ASV0330     -4.768880e-03 -4.970032e-03 -5.178962e-03 -5.395934e-03
## ASV0728      2.169547e-02  2.251759e-02  2.336462e-02  2.423699e-02
## ASV0499      6.565680e-03  6.854709e-03  7.155391e-03  7.468106e-03
## ASV0120     -9.662141e-03 -1.002650e-02 -1.040130e-02 -1.078661e-02
## ASV1446      4.262204e-03  4.285067e-03  4.298963e-03  4.303091e-03
## ASV17171    -1.908070e-02 -1.984923e-02 -2.064582e-02 -2.147137e-02
## ASV0533      1.791950e-03  1.878520e-03  1.968958e-03  2.063397e-03
## ASV2495     -6.730631e-03 -7.092669e-03 -7.473226e-03 -7.873047e-03
## ASV5582      5.836509e-03  5.940084e-03  6.039289e-03  6.133619e-03
## ASV1488      2.789354e-03  2.867045e-03  2.944596e-03  3.021788e-03
## ASV0682      4.844907e-03  5.058994e-03  5.281585e-03  5.512925e-03
## ASV0068     -7.434106e-03 -7.718486e-03 -8.011106e-03 -8.312008e-03
## ASV1987     -2.149865e-02 -2.246774e-02 -2.347667e-02 -2.452673e-02
## ASV0035     -2.770352e-03 -2.950964e-03 -3.143261e-03 -3.347934e-03
## ASV7192     -1.062052e-02 -1.099540e-02 -1.137959e-02 -1.177307e-02
## ASV0873     -2.005561e-02 -2.154685e-02 -2.312357e-02 -2.478881e-02
## ASV4749     -4.172060e-03 -4.504880e-03 -4.859700e-03 -5.237594e-03
## ASV2174      5.549417e-03  5.656306e-03  5.759441e-03  5.858342e-03
## ASV1476     -9.464306e-03 -9.897117e-03 -1.034864e-02 -1.081955e-02
## ASV0740     -2.625586e-02 -2.742248e-02 -2.863751e-02 -2.990267e-02
## ASV0170     -4.651564e-03 -4.838071e-03 -5.031079e-03 -5.230766e-03
## ASV2466     -2.146530e-02 -2.234425e-02 -2.325534e-02 -2.419952e-02
## ASV1709      7.271727e-03  7.570379e-03  7.882596e-03  8.209206e-03
## ASV6170     -3.531281e-02 -3.681983e-02 -3.838476e-02 -4.000937e-02
## ASV3673      1.794128e-02  1.873078e-02  1.955194e-02  2.040575e-02
## ASV1745     -5.227667e-03 -5.481078e-03 -5.746020e-03 -6.022917e-03
##                                                                    
## (Intercept)  1.285165e-01  1.333019e-01  1.382228e-01  1.432804e-01
## ASV1236      2.219021e-02  2.291603e-02  2.365796e-02  2.441605e-02
## ASV0421      5.004078e-03  5.268741e-03  5.545090e-03  5.833379e-03
## ASV0691     -1.276293e-02 -1.301038e-02 -1.325446e-02 -1.349490e-02
## ASV0899      1.900804e-02  1.959764e-02  2.019699e-02  2.080586e-02
## ASV1004      4.448540e-02  4.592046e-02  4.738483e-02  4.887837e-02
## ASV1041     -1.719403e-02 -1.767043e-02 -1.814890e-02 -1.862870e-02
## ASV1058      2.779713e-02  2.870447e-02  2.963178e-02  3.057912e-02
## ASV12542     9.922084e-03  1.021790e-02  1.051929e-02  1.082636e-02
## ASV1294      2.605152e-02  2.691249e-02  2.779350e-02  2.869475e-02
## ASV13113     1.225660e-02  1.282942e-02  1.342762e-02  1.405219e-02
## ASV1318      2.573523e-02  2.656805e-02  2.741850e-02  2.828660e-02
## ASV2269     -4.347990e-02 -4.481338e-02 -4.616783e-02 -4.754250e-02
## ASV2542      2.713911e-02  2.827416e-02  2.945191e-02  3.067365e-02
## ASV2660     -1.706593e-02 -1.758647e-02 -1.811571e-02 -1.865349e-02
## ASV2737      5.137902e-03  5.274197e-03  5.412475e-03  5.552793e-03
## ASV2840      2.028520e-02  2.078970e-02  2.129457e-02  2.179922e-02
## ASV3053      1.130157e-01  1.164036e-01  1.198520e-01  1.233607e-01
## ASV3077      7.409516e-03  7.644046e-03  7.883875e-03  8.129099e-03
## ASV3134      1.855024e-02  1.938312e-02  2.025116e-02  2.115567e-02
## ASV3140      2.136454e-02  2.216594e-02  2.299068e-02  2.383901e-02
## ASV3579      1.014700e-02  1.063639e-02  1.114713e-02  1.167986e-02
## ASV6119     -1.189590e-02 -1.226035e-02 -1.263048e-02 -1.300610e-02
## ASV7557     -2.417381e-02 -2.491429e-02 -2.566633e-02 -2.642951e-02
## ASV8422      5.838897e-03  6.021780e-03  6.208848e-03  6.400203e-03
## ASV1086     -6.987747e-04 -7.166620e-04 -7.351880e-04 -7.544281e-04
## ASV1310      1.172678e-02  1.209627e-02  1.247252e-02  1.285541e-02
## ASV15750    -1.158272e-03 -1.173126e-03 -1.186586e-03 -1.198526e-03
## ASV16905    -4.970311e-03 -5.122534e-03 -5.277135e-03 -5.434034e-03
## ASV2033      2.769624e-02  2.884521e-02  3.003461e-02  3.126533e-02
## ASV2089      1.050687e-02  1.082904e-02  1.115621e-02  1.148820e-02
## ASV2127      3.477750e-02  3.589983e-02  3.704581e-02  3.821547e-02
## ASV2725      2.611938e-02  2.688949e-02  2.767098e-02  2.846359e-02
## ASV2804     -1.028885e-02 -1.060397e-02 -1.092402e-02 -1.124885e-02
## ASV3075      2.667210e-02  2.772947e-02  2.882542e-02  2.996125e-02
## ASV3327      3.893199e-02  4.049228e-02  4.210509e-02  4.377154e-02
## ASV3342      3.294576e-02  3.425946e-02  3.561820e-02  3.702312e-02
## ASV3532     -3.519668e-02 -3.657479e-02 -3.800079e-02 -3.947617e-02
## ASV3600      1.650049e-02  1.714341e-02  1.780732e-02  1.849267e-02
## ASV4013      2.796205e-02  2.893011e-02  2.992170e-02  3.093686e-02
## ASV4136      2.699000e-02  2.783643e-02  2.870011e-02  2.958109e-02
## ASV4195      1.050317e-01  1.082491e-01  1.115170e-01  1.148339e-01
## ASV4407     -4.058254e-02 -4.182576e-02 -4.308853e-02 -4.437024e-02
## ASV4717      5.712821e-03  5.852145e-03  5.993075e-03  6.135706e-03
## ASV6794      1.573983e-02  1.621259e-02  1.669500e-02  1.718722e-02
## ASV8324     -2.082378e-02 -2.146183e-02 -2.210995e-02 -2.276782e-02
## ASV8981      7.224479e-04  8.056215e-04  8.949372e-04  9.906950e-04
## ASV9859      1.243339e-02  1.308931e-02  1.377931e-02  1.450501e-02
## ASV0936      2.446908e-02  2.540536e-02  2.636924e-02  2.736097e-02
## ASV12683    -2.848585e-04 -2.972802e-04 -3.094968e-04 -3.214074e-04
## ASV1293      1.348825e-02  1.390750e-02  1.433428e-02  1.476849e-02
## ASV13055     5.414393e-04  6.003173e-04  6.634190e-04  7.309464e-04
## ASV17063    -1.080733e-02 -1.113862e-02 -1.147515e-02 -1.181678e-02
## ASV2228      8.814101e-03  9.084308e-03  9.358802e-03  9.637455e-03
## ASV2769      2.534545e-03  2.659605e-03  2.789522e-03  2.924344e-03
## ASV2803      8.391284e-03  8.614109e-03  8.839275e-03  9.066730e-03
## ASV2896      1.004686e-02  1.048957e-02  1.095133e-02  1.143294e-02
## ASV3062      1.361593e-02  1.424151e-02  1.489252e-02  1.556964e-02
## ASV3107      1.770748e-02  1.842999e-02  1.917867e-02  1.995423e-02
## ASV3265      1.906317e-02  1.964502e-02  2.023664e-02  2.083785e-02
## ASV3666     -5.984483e-05 -7.416138e-05 -8.972418e-05 -1.065951e-04
## ASV4497      6.918963e-03  7.148247e-03  7.382715e-03  7.622384e-03
## ASV6914     -1.825109e-03 -1.917298e-03 -2.013487e-03 -2.113781e-03
## ASV0576     -1.962850e-02 -2.011340e-02 -2.060015e-02 -2.108836e-02
## ASV0673      2.748408e-02  2.842379e-02  2.938648e-02  3.037234e-02
## ASV0772      1.338114e-02  1.387422e-02  1.438236e-02  1.490591e-02
## ASV0862      4.282243e-03  4.542572e-03  4.815100e-03  5.100053e-03
## ASV0898      1.221859e-02  1.272525e-02  1.324922e-02  1.379084e-02
## ASV0910      1.347426e-02  1.402720e-02  1.460002e-02  1.519325e-02
## ASV0964     -7.757007e-03 -7.960443e-03 -8.165369e-03 -8.371661e-03
## ASV10059     1.074330e-02  1.122606e-02  1.172839e-02  1.225089e-02
## ASV10263    -1.645237e-02 -1.695722e-02 -1.747016e-02 -1.799095e-02
## ASV1088      2.365863e-02  2.463705e-02  2.565282e-02  2.670719e-02
## ASV1101      2.329714e-02  2.400916e-02  2.473297e-02  2.546833e-02
## ASV1183      7.326917e-03  7.607823e-03  7.897882e-03  8.197332e-03
## ASV11956     5.102567e-03  5.234313e-03  5.367678e-03  5.502699e-03
## ASV12774    -6.416441e-04 -7.046290e-04 -7.716489e-04 -8.428532e-04
## ASV1321      3.569668e-02  3.718434e-02  3.872539e-02  4.032105e-02
## ASV13793    -1.134512e-02 -1.169334e-02 -1.204713e-02 -1.240635e-02
## ASV14482     5.827853e-04  6.033046e-04  6.249536e-04  6.478207e-04
## ASV15483     5.750779e-03  5.977095e-03  6.210672e-03  6.451641e-03
## ASV2062      2.385055e-02  2.469639e-02  2.556549e-02  2.645822e-02
## ASV2132      2.174717e-02  2.260147e-02  2.348331e-02  2.439318e-02
## ASV2413      1.750946e-02  1.809636e-02  1.869771e-02  1.931369e-02
## ASV2490      4.860165e-02  5.000338e-02  5.142479e-02  5.286538e-02
## ASV2594      8.035826e-03  8.373522e-03  8.724947e-03  9.090647e-03
## ASV2822     -2.993381e-02 -3.085273e-02 -3.178638e-02 -3.273436e-02
## ASV2863      3.149438e-02  3.248004e-02  3.348534e-02  3.451029e-02
## ASV2910      1.172964e-02  1.210230e-02  1.248259e-02  1.287053e-02
## ASV2980      1.425321e-02  1.475163e-02  1.526282e-02  1.578691e-02
## ASV3307      2.382324e-02  2.455464e-02  2.529776e-02  2.605228e-02
## ASV3474      2.113155e-02  2.203629e-02  2.297492e-02  2.394830e-02
## ASV3502      1.920281e-02  1.992929e-02  2.067885e-02  2.145204e-02
## ASV4236      2.211396e-02  2.271009e-02  2.331143e-02  2.391762e-02
## ASV4842     -2.825225e-03 -2.900949e-03 -2.975630e-03 -3.048982e-03
## ASV4894     -1.134692e-02 -1.169531e-02 -1.204930e-02 -1.240872e-02
## ASV5290      1.082338e-02  1.123970e-02  1.166905e-02  1.211169e-02
## ASV5501      6.819058e-03  7.110053e-03  7.413637e-03  7.730389e-03
## ASV5795      7.425989e-03  7.717636e-03  8.018629e-03  8.329122e-03
## ASV5987     -3.169186e-02 -3.266499e-02 -3.365376e-02 -3.465774e-02
## ASV6267     -3.571305e-02 -3.680968e-02 -3.792393e-02 -3.905534e-02
## ASV6862      1.369467e-02  1.410743e-02  1.452783e-02  1.495586e-02
## ASV7145      6.072013e-03  6.271882e-03  6.477712e-03  6.689723e-03
## ASV7673     -1.134780e-02 -1.169628e-02 -1.205037e-02 -1.240993e-02
## ASV7789      9.236562e-03  9.699703e-03  1.018469e-02  1.069237e-02
## ASV7809      1.600618e-03  1.703291e-03  1.811285e-03  1.924752e-03
## ASV8002     -1.433274e-02 -1.477295e-02 -1.522025e-02 -1.567447e-02
## ASV8205      7.246385e-03  7.532619e-03  7.828564e-03  8.134447e-03
## ASV9155     -3.269682e-03 -3.351999e-03 -3.434255e-03 -3.516326e-03
## ASV9221      3.828667e-03  4.061662e-03  4.307533e-03  4.566831e-03
## ASV9311     -2.299505e-02 -2.370149e-02 -2.441937e-02 -2.514841e-02
## ASV9557     -1.571670e-02 -1.619959e-02 -1.669030e-02 -1.718867e-02
## ASV9936     -3.169756e-02 -3.267155e-02 -3.366137e-02 -3.466663e-02
## ASV1445      2.304584e-02  2.393536e-02  2.485297e-02  2.579916e-02
## ASV4232      1.076510e-02  1.128684e-02  1.183402e-02  1.240783e-02
## ASV6479      5.947785e-03  6.297549e-03  6.666528e-03  7.055582e-03
## ASV0142     -1.351283e-02 -1.393287e-02 -1.436091e-02 -1.479691e-02
## ASV0378      8.658347e-03  9.034734e-03  9.424795e-03  9.828768e-03
## ASV1122      2.297127e-02  2.388837e-02  2.483678e-02  2.581726e-02
## ASV0123     -1.183735e-02 -1.220038e-02 -1.256991e-02 -1.294587e-02
## ASV2064      4.726251e-03  4.801217e-03  4.871722e-03  4.937301e-03
## ASV4459     -4.826145e-04 -4.896440e-04 -4.971968e-04 -5.054155e-04
## ASV0448      6.975247e-03  7.283701e-03  7.604144e-03  7.936896e-03
## ASV0397      1.229060e-02  1.273150e-02  1.318426e-02  1.364901e-02
## ASV0485      1.370530e-02  1.417940e-02  1.466563e-02  1.516412e-02
## ASV1566      2.087480e-02  2.161877e-02  2.238263e-02  2.316661e-02
## ASV1365      1.843158e-02  1.909942e-02  1.978447e-02  2.048673e-02
## ASV1065      2.637390e-02  2.735659e-02  2.836819e-02  2.940910e-02
## ASV0722     -1.729892e-03 -1.815825e-03 -1.906251e-03 -2.001406e-03
## ASV12660    -1.264465e-02 -1.302497e-02 -1.341150e-02 -1.380413e-02
## ASV0223      3.901465e-03  4.043774e-03  4.190451e-03  4.341612e-03
## ASV0229      6.725560e-03  7.001036e-03  7.286624e-03  7.582642e-03
## ASV0877      1.131942e-03  1.093085e-03  1.045988e-03  9.899250e-04
## ASV0983      1.314705e-02  1.357650e-02  1.401483e-02  1.446197e-02
## ASV0626      3.400924e-03  3.591406e-03  3.790617e-03  3.998774e-03
## ASV4146      1.107805e-04  6.688663e-05  1.643944e-05 -4.118925e-05
## ASV4175     -1.888480e-02 -1.961818e-02 -2.037460e-02 -2.115444e-02
## ASV2082     -1.318707e-02 -1.390783e-02 -1.466595e-02 -1.546301e-02
## ASV2272      9.042086e-03  9.406004e-03  9.782980e-03  1.017339e-02
## ASV2245     -1.374083e-02 -1.428256e-02 -1.484169e-02 -1.541850e-02
## ASV0590     -1.342267e-02 -1.417127e-02 -1.495876e-02 -1.578675e-02
## ASV0217      3.503400e-03  3.741034e-03  3.991742e-03  4.255997e-03
## ASV0416      6.221554e-03  6.312003e-03  6.396540e-03  6.474650e-03
## ASV1056      1.395756e-02  1.453216e-02  1.512643e-02  1.574073e-02
## ASV7777     -1.835334e-02 -1.908576e-02 -1.984474e-02 -2.063118e-02
## ASV0455      3.083311e-03  3.191808e-03  3.302766e-03  3.416145e-03
## ASV0604      9.587155e-03  9.998006e-03  1.042410e-02  1.086580e-02
## ASV6100     -1.332949e-02 -1.389007e-02 -1.447268e-02 -1.507812e-02
## ASV11359    -2.655959e-02 -2.755682e-02 -2.858254e-02 -2.963697e-02
## ASV6604      4.150858e-03  4.325591e-03  4.506404e-03  4.693382e-03
## ASV5004     -9.389162e-03 -9.751061e-03 -1.012513e-02 -1.051173e-02
## ASV1483     -3.871202e-03 -4.009173e-03 -4.150718e-03 -4.295854e-03
## ASV9773     -1.247743e-02 -1.298061e-02 -1.350181e-02 -1.404160e-02
## ASV4059      2.267514e-03  2.440050e-03  2.622575e-03  2.815391e-03
## ASV1193      1.386767e-02  1.437568e-02  1.489838e-02  1.543602e-02
## ASV4610      3.654001e-04  4.609403e-04  5.624340e-04  6.699279e-04
## ASV0742      9.848229e-04  1.102813e-03  1.228051e-03  1.360700e-03
## ASV1502     -2.218146e-03 -2.357632e-03 -2.504105e-03 -2.657746e-03
## ASV0195     -5.643930e-04 -6.186688e-04 -6.763631e-04 -7.376010e-04
## ASV1213      7.476514e-03  7.659908e-03  7.843315e-03  8.026506e-03
## ASV1648     -1.198388e-02 -1.249208e-02 -1.302083e-02 -1.357095e-02
## ASV6984     -1.132703e-02 -1.181359e-02 -1.232029e-02 -1.284795e-02
## ASV0396      2.693387e-04  2.978010e-04  3.267223e-04  3.559097e-04
## ASV4297      1.159966e-02  1.192450e-02  1.225309e-02  1.258528e-02
## ASV2622      1.994722e-02  2.059948e-02  2.126615e-02  2.194728e-02
## ASV3512      1.250811e-02  1.315000e-02  1.382391e-02  1.453126e-02
## ASV2411      1.761842e-02  1.837009e-02  1.914976e-02  1.995814e-02
## ASV2291     -1.181544e-02 -1.246786e-02 -1.315257e-02 -1.387071e-02
## ASV0807      2.022282e-02  2.094181e-02  2.167912e-02  2.243482e-02
## ASV1292      3.362871e-03  3.429038e-03  3.494421e-03  3.558993e-03
## ASV1035      1.668999e-02  1.723439e-02  1.779169e-02  1.836209e-02
## ASV0070      1.321856e-03  1.419837e-03  1.523905e-03  1.634338e-03
## ASV0255      1.013075e-03  1.008929e-03  1.001113e-03  9.892761e-04
## ASV0057     -3.850706e-03 -3.937746e-03 -4.023857e-03 -4.108839e-03
## ASV0077     -4.381734e-04 -4.306784e-04 -4.219023e-04 -4.118293e-04
## ASV0625      9.026014e-03  9.286682e-03  9.550747e-03  9.818079e-03
## ASV2464      6.168104e-02  6.351800e-02  6.538515e-02  6.728209e-02
## ASV1315      2.333397e-02  2.434387e-02  2.539227e-02  2.648017e-02
## ASV2673      2.014815e-02  2.102770e-02  2.194158e-02  2.289080e-02
## ASV2161      8.542800e-03  8.923389e-03  9.319871e-03  9.732818e-03
## ASV0337     -4.381731e-03 -4.556299e-03 -4.736868e-03 -4.923594e-03
## ASV7680     -2.921950e-02 -3.040228e-02 -3.162626e-02 -3.289243e-02
## ASV0611      1.650409e-02  1.718731e-02  1.789589e-02  1.863061e-02
## ASV3118     -1.878179e-02 -1.960673e-02 -2.046380e-02 -2.135390e-02
## ASV1284     -1.921656e-03 -2.318135e-03 -2.748989e-03 -3.216262e-03
## ASV0889      1.059110e-02  1.096683e-02  1.135371e-02  1.175208e-02
## ASV4649     -5.867514e-03 -6.094920e-03 -6.329867e-03 -6.572549e-03
## ASV1108     -1.495479e-02 -1.565024e-02 -1.637539e-02 -1.713124e-02
## ASV0738      1.002509e-02  1.055437e-02  1.111031e-02  1.169406e-02
## ASV0473     -2.318305e-03 -2.431254e-03 -2.547766e-03 -2.667725e-03
## ASV0598     -5.817627e-03 -6.148514e-03 -6.497381e-03 -6.865050e-03
## ASV0429      6.984813e-03  7.181297e-03  7.379297e-03  7.578589e-03
## ASV1549      1.872064e-02  1.954054e-02  2.039226e-02  2.127665e-02
## ASV1203      1.146738e-02  1.185470e-02  1.225075e-02  1.265553e-02
## ASV4532      1.890567e-04  1.919405e-04  1.955085e-04  1.998997e-04
## ASV0274      2.781832e-03  2.900585e-03  3.022825e-03  3.148493e-03
## ASV0163     -7.901378e-03 -8.142506e-03 -8.388693e-03 -8.640040e-03
## ASV1298      7.843167e-04  8.221063e-04  8.633808e-04  9.085251e-04
## ASV9424     -2.344387e-02 -2.444025e-02 -2.547582e-02 -2.655192e-02
## ASV0412      1.947819e-02  2.012754e-02  2.079167e-02  2.147062e-02
## ASV0284      2.353972e-03  2.351802e-03  2.343415e-03  2.328306e-03
## ASV0620     -6.738530e-03 -7.083080e-03 -7.443730e-03 -7.821058e-03
## ASV0153     -2.475871e-02 -2.582727e-02 -2.693585e-02 -2.808542e-02
## ASV0498      7.758847e-03  8.046235e-03  8.340606e-03  8.641834e-03
## ASV0097      4.919383e-03  5.134992e-03  5.358972e-03  5.591544e-03
## ASV0104     -2.776417e-02 -2.872909e-02 -2.971712e-02 -3.072824e-02
## ASV1282      7.883414e-03  8.072136e-03  8.258198e-03  8.440939e-03
## ASV3883     -1.062380e-02 -1.111365e-02 -1.162277e-02 -1.215157e-02
## ASV0801      4.342262e-03  4.524499e-03  4.714192e-03  4.911681e-03
## ASV1611     -2.158889e-02 -2.251565e-02 -2.347810e-02 -2.447728e-02
## ASV0227     -5.659982e-03 -5.961617e-03 -6.277868e-03 -6.609276e-03
## ASV0833      6.664058e-03  6.921509e-03  7.186966e-03  7.460563e-03
## ASV0718      2.976120e-02  3.092344e-02  3.212339e-02  3.336179e-02
## ASV1139      7.662261e-04  6.729226e-04  5.689169e-04  4.536037e-04
## ASV0766     -5.318380e-03 -5.564209e-03 -5.819792e-03 -6.085358e-03
## ASV2091      1.883396e-02  1.936474e-02  1.990073e-02  2.044147e-02
## ASV1238     -2.444289e-02 -2.552846e-02 -2.666149e-02 -2.784403e-02
## ASV9193     -5.001312e-03 -5.321498e-03 -5.660876e-03 -6.020400e-03
## ASV0290      1.629095e-03  1.651271e-03  1.673296e-03  1.695299e-03
## ASV0231      7.554777e-03  7.794811e-03  8.038802e-03  8.286577e-03
## ASV0185      7.591521e-03  7.989435e-03  8.407126e-03  8.845418e-03
## ASV2330      7.404750e-03  7.598966e-03  7.794905e-03  7.992514e-03
## ASV3119     -6.671346e-03 -7.013189e-03 -7.371494e-03 -7.746917e-03
## ASV2368     -1.354478e-02 -1.418120e-02 -1.484699e-02 -1.554342e-02
## ASV0122     -4.937676e-03 -5.109793e-03 -5.286326e-03 -5.467318e-03
## ASV1044      1.558971e-02  1.626389e-02  1.696472e-02  1.769309e-02
## ASV0160     -4.425586e-03 -4.549942e-03 -4.676322e-03 -4.804780e-03
## ASV0326      1.492483e-03  1.543619e-03  1.595551e-03  1.648203e-03
## ASV1388      2.581599e-02  2.671069e-02  2.762702e-02  2.856503e-02
## ASV0792      1.745071e-02  1.798762e-02  1.853335e-02  1.908766e-02
## ASV0036     -7.368579e-03 -7.680359e-03 -8.003053e-03 -8.336834e-03
## ASV2125      1.896147e-02  1.963702e-02  2.032977e-02  2.103974e-02
## ASV1075     -4.084906e-04 -4.335747e-04 -4.605136e-04 -4.894494e-04
## ASV0390      1.268106e-02  1.326062e-02  1.386555e-02  1.449685e-02
## ASV3790     -1.599667e-02 -1.664579e-02 -1.731787e-02 -1.801351e-02
## ASV1535     -6.157059e-03 -6.461964e-03 -6.780421e-03 -7.112845e-03
## ASV0263      1.849663e-02  1.920143e-02  1.992806e-02  2.067692e-02
## ASV0675      3.041499e-02  3.168317e-02  3.299775e-02  3.435997e-02
## ASV3348      2.877350e-03  3.009622e-03  3.147120e-03  3.289961e-03
## ASV0058     -7.534892e-03 -7.790787e-03 -8.052416e-03 -8.319743e-03
## ASV4142      9.537575e-03  9.823081e-03  1.011322e-02  1.040794e-02
## ASV0059     -5.889250e-03 -6.081436e-03 -6.277402e-03 -6.477089e-03
## ASV0013     -1.163142e-02 -1.206650e-02 -1.251448e-02 -1.297554e-02
## ASV0033     -6.360987e-03 -6.629928e-03 -6.908413e-03 -7.196621e-03
## ASV4354     -7.193281e-03 -7.485939e-03 -7.789411e-03 -8.104018e-03
## ASV0022     -5.384770e-03 -5.614208e-03 -5.852017e-03 -6.098376e-03
## ASV0134     -5.861021e-03 -6.145134e-03 -6.442604e-03 -6.754021e-03
## ASV0415      1.180183e-03  1.236728e-03  1.295288e-03  1.355879e-03
## ASV10103    -2.889640e-02 -3.010587e-02 -3.135981e-02 -3.265941e-02
## ASV1613      1.636539e-02  1.684860e-02  1.733706e-02  1.783024e-02
## ASV0135     -1.780232e-03 -1.818981e-03 -1.857170e-03 -1.894704e-03
## ASV0469     -2.321997e-02 -2.403995e-02 -2.488291e-02 -2.574930e-02
## ASV0471      1.511317e-02  1.568323e-02  1.627140e-02  1.687813e-02
## ASV0451     -4.457787e-03 -4.701925e-03 -4.957836e-03 -5.225894e-03
## ASV0747      8.918074e-03  9.258116e-03  9.608088e-03  9.968061e-03
## ASV1314     -1.065229e-02 -1.114413e-02 -1.165763e-02 -1.219363e-02
## ASV0425     -2.591871e-02 -2.670533e-02 -2.750528e-02 -2.831841e-02
## ASV0559     -7.859834e-03 -8.185397e-03 -8.524497e-03 -8.877742e-03
## ASV0148     -2.337438e-04 -1.769614e-04 -1.138719e-04 -4.407155e-05
## ASV0129      4.640373e-03  4.939854e-03  5.257054e-03  5.592815e-03
## ASV1072      1.033621e-03  1.026878e-03  1.016756e-03  1.003011e-03
## ASV2390      1.165299e-02  1.191303e-02  1.216913e-02  1.242057e-02
## ASV0548      1.014110e-02  1.050597e-02  1.088051e-02  1.126478e-02
## ASV0168     -4.891404e-03 -5.057782e-03 -5.228251e-03 -5.402851e-03
## ASV0066     -5.559554e-03 -5.743461e-03 -5.930828e-03 -6.121546e-03
## ASV0468     -3.349357e-03 -3.484274e-03 -3.624165e-03 -3.769206e-03
## ASV0172     -9.160528e-04 -9.120089e-04 -9.052263e-04 -8.954986e-04
## ASV0236      3.060907e-03  3.313852e-03  3.583027e-03  3.869143e-03
## ASV0250      1.184544e-02  1.243946e-02  1.306213e-02  1.371465e-02
## ASV0338      4.478920e-03  4.652237e-03  4.830064e-03  5.012339e-03
## ASV0450     -1.534090e-03 -1.625446e-03 -1.721904e-03 -1.823701e-03
## ASV0377      6.922479e-03  7.151868e-03  7.385670e-03  7.623755e-03
## ASV1022     -1.916466e-05 -1.533671e-07  2.138907e-05  4.569125e-05
## ASV6174     -6.376642e-04 -6.817388e-04 -7.281425e-04 -7.768888e-04
## ASV0786     -2.284666e-03 -2.411856e-03 -2.544670e-03 -2.683199e-03
## ASV0053     -8.305493e-03 -8.620584e-03 -8.945145e-03 -9.279313e-03
## ASV0697     -4.366067e-03 -4.511024e-03 -4.659658e-03 -4.812057e-03
## ASV0785      9.691219e-03  1.002363e-02  1.036413e-02  1.071279e-02
## ASV1967     -9.538770e-03 -9.870295e-03 -1.021053e-02 -1.055956e-02
## ASV0385      4.104421e-03  4.273742e-03  4.448180e-03  4.627710e-03
## ASV0295      1.741561e-03  1.855873e-03  1.977010e-03  2.105300e-03
## ASV0072     -6.956031e-03 -7.162974e-03 -7.372122e-03 -7.583236e-03
## ASV0157      7.001078e-04  8.053093e-04  9.194342e-04  1.043024e-03
## ASV0501      1.811315e-02  1.879867e-02  1.950367e-02  2.022822e-02
## ASV10729    -2.371266e-02 -2.466683e-02 -2.565381e-02 -2.667437e-02
## ASV1470      8.220290e-03  8.401240e-03  8.579147e-03  8.753437e-03
## ASV0050     -1.785058e-02 -1.846149e-02 -1.908641e-02 -1.972530e-02
## ASV0411     -5.001773e-03 -5.220960e-03 -5.449174e-03 -5.686763e-03
## ASV0549      7.612881e-03  7.924526e-03  8.246993e-03  8.580514e-03
## ASV0184      2.326318e-03  2.419714e-03  2.516847e-03  2.617892e-03
## ASV0705      3.892018e-03  4.004280e-03  4.117255e-03  4.230752e-03
## ASV1715      9.834525e-03  1.020635e-02  1.058929e-02  1.098351e-02
## ASV0603      1.928223e-03  2.027005e-03  2.131335e-03  2.241544e-03
## ASV0826      1.584915e-02  1.642492e-02  1.701710e-02  1.762597e-02
## ASV0034     -4.608240e-03 -4.753098e-03 -4.900381e-03 -5.050012e-03
## ASV0838     -6.104580e-04 -8.395699e-04 -1.091936e-03 -1.369217e-03
## ASV0614     -4.316032e-03 -4.471664e-03 -4.631606e-03 -4.795918e-03
## ASV0014     -1.160061e-02 -1.202112e-02 -1.245304e-02 -1.289647e-02
## ASV0585     -1.404992e-03 -1.563148e-03 -1.731934e-03 -1.911717e-03
## ASV0016     -1.213242e-02 -1.257283e-02 -1.302526e-02 -1.348981e-02
## ASV5394     -9.612933e-03 -9.981266e-03 -1.036055e-02 -1.075087e-02
## ASV0666      1.737625e-02  1.791177e-02  1.845631e-02  1.900971e-02
## ASV2085      1.599242e-04 -1.450475e-05 -2.054886e-04 -4.139297e-04
## ASV0003     -8.255686e-03 -8.554974e-03 -8.862442e-03 -9.178169e-03
## ASV0346      4.932426e-03  5.137052e-03  5.348315e-03  5.566267e-03
## ASV0267      8.150151e-04  8.735230e-04  9.346230e-04  9.982670e-04
## ASV0353      7.673946e-03  7.998822e-03  8.335767e-03  8.685099e-03
## ASV2419      1.717137e-02  1.776893e-02  1.838091e-02  1.900726e-02
## ASV0447      1.128620e-02  1.176203e-02  1.225532e-02  1.276650e-02
## ASV0654      1.439407e-02  1.491371e-02  1.544698e-02  1.599393e-02
## ASV0151      3.099763e-03  3.264517e-03  3.437315e-03  3.618443e-03
## ASV0065     -5.351650e-03 -5.537542e-03 -5.727997e-03 -5.923032e-03
## ASV0527      1.355404e-02  1.404238e-02  1.454382e-02  1.505847e-02
## ASV4055     -3.265049e-03 -3.446839e-03 -3.639519e-03 -3.843771e-03
## ASV0166     -6.010523e-03 -6.194670e-03 -6.381819e-03 -6.571907e-03
## ASV0417     -1.914149e-03 -1.947120e-03 -1.978680e-03 -2.008690e-03
## ASV0078     -3.580182e-03 -3.685256e-03 -3.791124e-03 -3.897615e-03
## ASV0322      5.459923e-04  6.373520e-04  7.372600e-04  8.462766e-04
## ASV0156     -1.072685e-02 -1.116918e-02 -1.162790e-02 -1.210355e-02
## ASV0648     -2.353814e-02 -2.450509e-02 -2.550629e-02 -2.654255e-02
## ASV0407     -2.022139e-03 -2.118090e-03 -2.218515e-03 -2.323607e-03
## ASV2030     -3.811296e-03 -3.987655e-03 -4.173216e-03 -4.368497e-03
## ASV0300      3.044384e-03  3.176103e-03  3.312666e-03  3.454174e-03
## ASV1150      8.959902e-04  9.398542e-04  9.853717e-04  1.032546e-03
## ASV0958      9.807410e-03  1.026156e-02  1.073567e-02  1.123051e-02
## ASV0216     -8.480065e-03 -8.804639e-03 -9.141095e-03 -9.489934e-03
## ASV0446      1.435320e-02  1.492982e-02  1.552555e-02  1.614072e-02
## ASV0367     -9.043622e-03 -9.397695e-03 -9.763306e-03 -1.014069e-02
## ASV0200     -5.281280e-03 -5.480769e-03 -5.685929e-03 -5.896783e-03
## ASV0334     -1.481375e-03 -1.495893e-03 -1.509448e-03 -1.522080e-03
## ASV1311      2.041401e-03  2.059528e-03  2.074221e-03  2.085181e-03
## ASV0458      2.928641e-03  2.958901e-03  2.985356e-03  3.007713e-03
## ASV1371      1.042402e-03  1.085342e-03  1.129290e-03  1.174187e-03
## ASV0418      9.714110e-03  1.001018e-02  1.031119e-02  1.061705e-02
## ASV0004      1.353283e-03  1.391907e-03  1.430982e-03  1.470484e-03
## ASV1943      1.874953e-02  1.903029e-02  1.929918e-02  1.955535e-02
## ASV1495     -5.058139e-03 -5.368445e-03 -5.696383e-03 -6.042754e-03
## ASV0901     -1.115549e-02 -1.164240e-02 -1.214935e-02 -1.267707e-02
## ASV0628      3.644674e-03  3.714408e-03  3.781619e-03  3.845972e-03
## ASV0400      2.608886e-03  2.677608e-03  2.745846e-03  2.813370e-03
## ASV0116     -3.227842e-03 -3.365436e-03 -3.508369e-03 -3.656811e-03
## ASV0788      2.891115e-02  3.016232e-02  3.146374e-02  3.281716e-02
## ASV0117      2.357664e-03  2.465873e-03  2.578551e-03  2.695833e-03
## ASV3137     -5.051903e-04 -5.192532e-04 -5.332536e-04 -5.471360e-04
## ASV0001      1.409507e-03  1.447422e-03  1.485615e-03  1.524057e-03
## ASV1651      4.252264e-03  4.379703e-03  4.509250e-03  4.640893e-03
## ASV1692      2.370984e-02  2.471369e-02  2.575582e-02  2.683741e-02
## ASV0660      4.811040e-03  4.869345e-03  4.920808e-03  4.964780e-03
## ASV0508      2.201987e-04  2.218101e-04  2.229422e-04  2.235363e-04
## ASV1660     -5.698324e-03 -5.962886e-03 -6.237845e-03 -6.523414e-03
## ASV0233      6.725823e-03  6.986942e-03  7.256504e-03  7.534691e-03
## ASV1343     -1.338947e-02 -1.395551e-02 -1.454338e-02 -1.515380e-02
## ASV0209      4.741235e-03  4.867888e-03  4.995033e-03  5.122481e-03
## ASV0193     -5.689393e-03 -5.844334e-03 -5.999763e-03 -6.155413e-03
## ASV0357      4.398278e-03  4.645777e-03  4.907079e-03  5.182879e-03
## ASV0198      4.994749e-03  5.173400e-03  5.357316e-03  5.546630e-03
## ASV0007      1.143863e-03  1.169659e-03  1.195245e-03  1.220581e-03
## ASV1772     -9.207112e-04 -8.689061e-04 -8.071317e-04 -7.343904e-04
## ASV0009      8.575611e-04  8.723868e-04  8.866854e-04  9.004144e-04
## ASV0006     -1.768275e-03 -1.848327e-03 -1.931616e-03 -2.018231e-03
## ASV0011     -5.371202e-03 -5.590043e-03 -5.816612e-03 -6.051104e-03
## ASV0015      6.267221e-04  6.356106e-04  6.438502e-04  6.513815e-04
## ASV0017      7.316730e-04  7.443681e-04  7.565788e-04  7.682566e-04
## ASV0235     -5.061503e-03 -5.271714e-03 -5.489707e-03 -5.715722e-03
## ASV0382      3.660243e-03  3.784649e-03  3.910432e-03  4.037311e-03
## ASV2357      1.622018e-02  1.688862e-02  1.758160e-02  1.829982e-02
## ASV0567     -3.425084e-03 -3.584980e-03 -3.752566e-03 -3.928222e-03
## ASV0165      2.641058e-03  2.744467e-03  2.851104e-03  2.961014e-03
## ASV0005      3.495279e-03  3.619073e-03  3.745913e-03  3.875794e-03
## ASV0384      4.899208e-04  5.492868e-04  6.135215e-04  6.829306e-04
## ASV0002      5.928594e-04  6.127410e-04  6.331436e-04  6.540771e-04
## ASV3017      1.583802e-02  1.629531e-02  1.675764e-02  1.722464e-02
## ASV0091     -5.077104e-04 -5.315604e-04 -5.568183e-04 -5.835918e-04
## ASV0186     -7.189236e-03 -7.447258e-03 -7.711564e-03 -7.982100e-03
## ASV0370      3.559024e-03  3.680204e-03  3.804424e-03  3.931737e-03
## ASV0018      4.555503e-03  4.720687e-03  4.890256e-03  5.064232e-03
## ASV1377      4.024213e-02  4.149556e-02  4.277034e-02  4.406597e-02
## ASV0019      4.811325e-03  4.987421e-03  5.168335e-03  5.354104e-03
## ASV0023     -3.359983e-03 -3.497389e-03 -3.639433e-03 -3.786190e-03
## ASV2194      5.859392e-03  6.125573e-03  6.403234e-03  6.692807e-03
## ASV1155      1.730783e-02  1.790286e-02  1.851433e-02  1.914261e-02
## ASV0510     -3.614965e-03 -3.696824e-03 -3.779110e-03 -3.861870e-03
## ASV2371     -1.027702e-02 -1.061337e-02 -1.095694e-02 -1.130768e-02
## ASV0024     -4.145237e-03 -4.313685e-03 -4.487800e-03 -4.667683e-03
## ASV2452      8.465515e-03  8.646424e-03  8.824190e-03  8.998335e-03
## ASV2332     -3.100915e-02 -3.210295e-02 -3.322742e-02 -3.438310e-02
## ASV2591      1.197251e-02  1.250540e-02  1.305638e-02  1.362557e-02
## ASV0521      8.484841e-03  8.837399e-03  9.202871e-03  9.581613e-03
## ASV5542      7.924453e-03  8.237901e-03  8.561630e-03  8.895871e-03
## ASV0336     -1.855888e-03 -1.961945e-03 -2.073511e-03 -2.190824e-03
## ASV10102     1.467717e-02  1.526089e-02  1.586332e-02  1.648472e-02
## ASV16823    -1.675210e-02 -1.724195e-02 -1.773971e-02 -1.824528e-02
## ASV3104      8.667809e-02  8.921252e-02  9.178784e-02  9.440355e-02
## ASV0781      1.502325e-02  1.558714e-02  1.616885e-02  1.676883e-02
## ASV10899     1.332266e-02  1.400285e-02  1.471528e-02  1.546121e-02
## ASV11222    -2.948531e-02 -3.034739e-02 -3.122337e-02 -3.211308e-02
## ASV11327    -2.647230e-02 -2.724625e-02 -2.803268e-02 -2.883142e-02
## ASV12458    -2.948466e-02 -3.034663e-02 -3.122250e-02 -3.211207e-02
## ASV1636      1.869327e-02  1.931092e-02  1.994254e-02  2.058820e-02
## ASV1890     -1.160167e-02 -1.187256e-02 -1.214485e-02 -1.241851e-02
## ASV2898      2.518972e-02  2.602742e-02  2.688432e-02  2.776054e-02
## ASV8328      1.026409e-02  1.092743e-02  1.162836e-02  1.236849e-02
## ASV0709     -2.947809e-02 -3.050128e-02 -3.154939e-02 -3.262251e-02
## ASV0856      3.000500e-02  3.128507e-02  3.261224e-02  3.398762e-02
## ASV0909      1.309538e-02  1.381213e-02  1.456418e-02  1.535279e-02
## ASV0937     -2.052998e-02 -2.142064e-02 -2.234817e-02 -2.331399e-02
## ASV11390    -4.208016e-02 -4.331019e-02 -4.456002e-02 -4.582938e-02
## ASV11966     1.563303e-02  1.632143e-02  1.703548e-02  1.777575e-02
## ASV12990     7.871916e-03  8.115151e-03  8.363084e-03  8.615747e-03
## ASV14797     1.133425e-02  1.167676e-02  1.202549e-02  1.238045e-02
## ASV14904    -6.038325e-02 -6.214818e-02 -6.394149e-02 -6.576281e-02
## ASV15304     1.094546e-02  1.145892e-02  1.199283e-02  1.254767e-02
## ASV16696    -2.086334e-02 -2.147312e-02 -2.209270e-02 -2.272196e-02
## ASV1690      5.001295e-02  5.204994e-02  5.415153e-02  5.631831e-02
## ASV2029      2.904423e-02  3.007819e-02  3.114058e-02  3.223182e-02
## ASV2834      4.028740e-02  4.185273e-02  4.346621e-02  4.512847e-02
## ASV4003      4.103131e-02  4.301411e-02  4.509062e-02  4.726501e-02
## ASV4064      1.962119e-02  2.040459e-02  2.121404e-02  2.205012e-02
## ASV4294      1.574121e-02  1.653025e-02  1.735633e-02  1.822088e-02
## ASV4609      9.828633e-03  1.018677e-02  1.055643e-02  1.093798e-02
## ASV6283     -1.950248e-02 -2.007245e-02 -2.065157e-02 -2.123974e-02
## ASV6491     -2.795289e-02 -2.876981e-02 -2.959985e-02 -3.044284e-02
## ASV7453      2.119967e-02  2.215020e-02  2.313727e-02  2.416174e-02
## ASV7959      1.022642e-02  1.077604e-02  1.135279e-02  1.195776e-02
## ASV8219      2.415715e-01  2.486311e-01  2.558041e-01  2.630890e-01
## ASV8547     -2.502604e-02 -2.575738e-02 -2.650047e-02 -2.725515e-02
## ASV9319      1.574298e-02  1.642900e-02  1.714271e-02  1.788506e-02
## ASV9382     -4.896663e-02 -5.039757e-02 -5.185149e-02 -5.332809e-02
## ASV11516    -3.270565e-02 -3.366139e-02 -3.463248e-02 -3.561872e-02
## ASV14377    -2.361517e-02 -2.430526e-02 -2.500643e-02 -2.571854e-02
## ASV1867      2.481812e-02  2.583289e-02  2.688390e-02  2.797217e-02
## ASV1895      7.988405e-03  8.131300e-03  8.267907e-03  8.397529e-03
## ASV3168      1.160354e-02  1.191957e-02  1.223785e-02  1.255808e-02
## ASV4449      7.970331e-02  8.277395e-02  8.594720e-02  8.922580e-02
## ASV6596      2.226349e-02  2.335068e-02  2.448804e-02  2.567751e-02
## ASV7492      1.797232e-03  2.043683e-03  2.307734e-03  2.590144e-03
## ASV9854     -4.847477e-03 -4.983793e-03 -5.121978e-03 -5.261969e-03
## ASV6296      3.962769e-01  4.078569e-01  4.196230e-01  4.315727e-01
## ASV4201      7.858222e-03  8.380725e-03  8.934173e-03  9.520050e-03
## ASV0552      1.677029e-02  1.743173e-02  1.811419e-02  1.881799e-02
## ASV3671     -1.066560e-02 -1.110999e-02 -1.157371e-02 -1.205771e-02
## ASV3529      6.524683e-04  7.815669e-04  9.186209e-04  1.063762e-03
## ASV1060      5.222361e-03  5.471374e-03  5.732273e-03  6.005613e-03
## ASV0239     -4.168023e-03 -4.268291e-03 -4.368463e-03 -4.468399e-03
## ASV5711     -2.390858e-02 -2.475335e-02 -2.562136e-02 -2.651294e-02
## ASV4152     -3.728405e-02 -3.871973e-02 -4.019996e-02 -4.172539e-02
## ASV1461      1.383041e-02  1.417693e-02  1.452426e-02  1.487203e-02
## ASV2877      7.435720e-03  7.627275e-03  7.818951e-03  8.010431e-03
## ASV0012      1.661693e-03  1.725515e-03  1.791399e-03  1.859393e-03
## ASV9823      2.722098e-04  1.847454e-04  8.746559e-05 -2.026936e-05
## ASV0008      1.736976e-03  1.802628e-03  1.870368e-03  1.940244e-03
## ASV7832     -2.285426e-02 -2.378421e-02 -2.474711e-02 -2.574378e-02
## ASV1915     -2.668999e-03 -2.782297e-03 -2.900855e-03 -3.024936e-03
## ASV0055     -2.717751e-03 -2.854870e-03 -2.998460e-03 -3.148770e-03
## ASV0032      4.271408e-04  4.272375e-04  4.266196e-04  4.252774e-04
## ASV2977     -3.041778e-02 -3.156402e-02 -3.274388e-02 -3.395769e-02
## ASV0466      1.835215e-02  1.880587e-02  1.925905e-02  1.971099e-02
## ASV3866      1.869730e-02  1.949845e-02  2.033133e-02  2.119704e-02
## ASV0040      6.277456e-03  6.525022e-03  6.780772e-03  7.044876e-03
## ASV0496     -3.982642e-03 -4.233954e-03 -4.498812e-03 -4.777698e-03
## ASV0052      5.300121e-03  5.510860e-03  5.728811e-03  5.954164e-03
## ASV3828     -1.389285e-02 -1.429109e-02 -1.469511e-02 -1.510478e-02
## ASV1930      7.520522e-03  7.735489e-03  7.952389e-03  8.171021e-03
## ASV2126      1.457933e-02  1.510410e-02  1.564404e-02  1.619948e-02
## ASV0793      2.057484e-02  2.141967e-02  2.229456e-02  2.320032e-02
## ASV0299     -8.283444e-04 -8.949004e-04 -9.672084e-04 -1.045726e-03
## ASV0208      1.431057e-02  1.488687e-02  1.548387e-02  1.610219e-02
## ASV0511     -3.977641e-03 -4.070159e-03 -4.163004e-03 -4.256187e-03
## ASV1123     -1.286248e-02 -1.319552e-02 -1.352995e-02 -1.386536e-02
## ASV0099      9.466040e-04  1.005014e-03  1.066998e-03  1.132745e-03
## ASV0752     -1.150563e-02 -1.201510e-02 -1.254517e-02 -1.309652e-02
## ASV0883      1.538914e-02  1.604476e-02  1.672402e-02  1.742738e-02
## ASV0683      1.958507e-02  2.041392e-02  2.127373e-02  2.216536e-02
## ASV4117     -2.932595e-02 -3.052201e-02 -3.176180e-02 -3.304661e-02
## ASV2172      5.950222e-04  5.634797e-04  5.271287e-04  4.856240e-04
## ASV0330     -5.621224e-03 -5.855112e-03 -6.097889e-03 -6.349856e-03
## ASV0728      2.513511e-02  2.605943e-02  2.701037e-02  2.798835e-02
## ASV0499      7.793237e-03  8.131174e-03  8.482312e-03  8.847048e-03
## ASV0120     -1.118251e-02 -1.158903e-02 -1.200621e-02 -1.243405e-02
## ASV1446      4.296611e-03  4.278646e-03  4.248279e-03  4.204558e-03
## ASV17171    -2.232681e-02 -2.321307e-02 -2.413115e-02 -2.508201e-02
## ASV0533      2.161973e-03  2.264818e-03  2.372067e-03  2.483855e-03
## ASV2495     -8.292882e-03 -8.733485e-03 -9.195612e-03 -9.680021e-03
## ASV5582      6.222547e-03  6.305524e-03  6.381979e-03  6.451315e-03
## ASV1488      3.098384e-03  3.174132e-03  3.248759e-03  3.321978e-03
## ASV0682      5.753264e-03  6.002848e-03  6.261920e-03  6.530724e-03
## ASV0068     -8.621216e-03 -8.938736e-03 -9.264559e-03 -9.598654e-03
## ASV1987     -2.561921e-02 -2.675541e-02 -2.793666e-02 -2.916425e-02
## ASV0035     -3.565705e-03 -3.797330e-03 -4.043597e-03 -4.305329e-03
## ASV7192     -1.217581e-02 -1.258773e-02 -1.300877e-02 -1.343881e-02
## ASV0873     -2.654552e-02 -2.839666e-02 -3.034510e-02 -3.239367e-02
## ASV4749     -5.639658e-03 -6.067008e-03 -6.520778e-03 -7.002121e-03
## ASV2174      5.952515e-03  6.041452e-03  6.124628e-03  6.201508e-03
## ASV1476     -1.131054e-02 -1.182230e-02 -1.235554e-02 -1.291098e-02
## ASV0740     -3.121978e-02 -3.259066e-02 -3.401720e-02 -3.550133e-02
## ASV0170     -5.437311e-03 -5.650898e-03 -5.871715e-03 -6.099950e-03
## ASV2466     -2.517775e-02 -2.619102e-02 -2.724031e-02 -2.832661e-02
## ASV1709      8.551096e-03  8.909217e-03  9.284589e-03  9.678303e-03
## ASV6170     -4.169542e-02 -4.344468e-02 -4.525894e-02 -4.714001e-02
## ASV3673      2.129321e-02  2.221532e-02  2.317311e-02  2.416759e-02
## ASV1745     -6.312199e-03 -6.614301e-03 -6.929661e-03 -7.258720e-03
##                                                                    
## (Intercept)  1.484760e-01  0.1538104716  1.592847e-01  0.1648995239
## ASV1236      2.519032e-02  0.0259807715  2.678741e-02  0.0276102272
## ASV0421      6.133845e-03  0.0064467090  6.772169e-03  0.0071104026
## ASV0691     -1.373141e-02 -0.0139637091 -1.419156e-02 -0.0144147367
## ASV0899      2.142403e-02  0.0220512719  2.268736e-02  0.0233320499
## ASV1004      5.040093e-02  0.0519523425  5.353242e-02  0.0551409777
## ASV1041     -1.910904e-02 -0.0195891416 -2.006815e-02 -0.0205452050
## ASV1058      3.154657e-02  0.0325341906  3.354203e-02  0.0345701416
## ASV12542     1.113917e-02  0.0114578608  1.178254e-02  0.0121133418
## ASV1294      2.961643e-02  0.0305587436  3.152190e-02  0.0325061265
## ASV13113     1.470413e-02  0.0153844491  1.609421e-02  0.0168344739
## ASV1318      2.917237e-02  0.0300758090  3.099694e-02  0.0319357796
## ASV2269     -4.893662e-02 -0.0503493299 -5.177974e-02 -0.0532269095
## ASV2542      3.194067e-02  0.0332543147  3.461590e-02  0.0360267732
## ASV2660     -1.919964e-02 -0.0197539701 -2.031630e-02 -0.0208864242
## ASV2737      5.695222e-03  0.0058398465  5.986759e-03  0.0061360645
## ASV2840      2.230302e-02  0.0228053824  2.330569e-02  0.0238033388
## ASV3053      1.269297e-01  0.1305590475  1.342489e-01  0.1379992159
## ASV3077      8.379820e-03  0.0086361464  8.898196e-03  0.0091660908
## ASV3134      2.209796e-02  0.0230793826  2.410131e-02  0.0251651546
## ASV3140      2.471118e-02  0.0256074042  2.652787e-02  0.0274727494
## ASV3579      1.223525e-02  0.0128139299  1.341654e-02  0.0140437079
## ASV6119     -1.338700e-02 -0.0137729528 -1.416372e-02 -0.0145590716
## ASV7557     -2.720342e-02 -0.0279876009 -2.878158e-02 -0.0295848799
## ASV8422      6.595956e-03  0.0067962285  7.001150e-03  0.0072108574
## ASV1086     -7.744638e-04 -0.0007953823 -8.172755e-04 -0.0008402390
## ASV1310      1.324483e-02  0.0136406496  1.404273e-02  0.0144509085
## ASV15750    -1.208815e-03 -0.0012173195 -1.223904e-03 -0.0012284326
## ASV16905    -5.593147e-03 -0.0057543855 -5.917657e-03 -0.0060828690
## ASV2033      3.253829e-02  0.0338543503  3.521440e-02  0.0366193100
## ASV2089      1.182483e-02  0.0121659033  1.251121e-02  0.0128605630
## ASV2127      3.940880e-02  0.0406258219  4.186652e-02  0.0431309055
## ASV2725      2.926700e-02  0.0300809225  3.090505e-02  0.0317390769
## ASV2804     -1.157828e-02 -0.0119121264 -1.225022e-02 -0.0125923682
## ASV3075      3.113833e-02  0.0323580359  3.362180e-02  0.0349310764
## ASV3327      4.549275e-02  0.0472698291  4.910388e-02  0.0509959881
## ASV3342      3.847535e-02  0.0399760188  4.152628e-02  0.0431273052
## ASV3532     -4.100249e-02 -0.0425813384 -4.421438e-02 -0.0459033595
## ASV3600      1.919990e-02  0.0199294433  2.068173e-02  0.0214571759
## ASV4013      3.197561e-02  0.0330379327  3.412378e-02  0.0352330688
## ASV4136      3.047939e-02  0.0313950651  3.232815e-02  0.0332786794
## ASV4195      1.181980e-01  0.1216076964  1.250611e-01  0.1285565104
## ASV4407     -4.567025e-02 -0.0469878973 -4.832250e-02 -0.0496733690
## ASV4717      6.280148e-03  0.0064265258  6.574980e-03  0.0067256632
## ASV6794      1.768942e-02  0.0182018073  1.872457e-02  0.0192579376
## ASV8324     -2.343513e-02 -0.0241115349 -2.479671e-02 -0.0254903095
## ASV8981      1.093198e-03  0.0012027514  1.319662e-03  0.0014442341
## ASV9859      1.526807e-02  0.0160702394  1.691329e-02  0.0177990772
## ASV0936      2.838079e-02  0.0294289165  3.050553e-02  0.0316107746
## ASV12683    -3.329034e-04 -0.0003438691 -3.541823e-04 -0.0003637150
## ASV1293      1.521001e-02  0.0156587416  1.611457e-02  0.0165773907
## ASV13055     8.031038e-04  0.0008800967  9.621315e-04  0.0010494144
## ASV17063    -1.216334e-02 -0.0125146626 -1.287058e-02 -0.0132309311
## ASV2228      9.920137e-03  0.0102067123  1.049704e-02  0.0107909900
## ASV2769      3.064106e-03  0.0032088295  3.358519e-03  0.0035131607
## ASV2803      9.296428e-03  0.0095283315  9.762407e-03  0.0099986296
## ASV2896      1.193523e-02  0.0124590570  1.300532e-02  0.0135749474
## ASV3062      1.627356e-02  0.0170049277  1.776438e-02  0.0185525475
## ASV3107      2.075743e-02  0.0215890155  2.244972e-02  0.0233402929
## ASV3265      2.144847e-02  0.0220683210  2.269721e-02  0.0233349310
## ASV3666     -1.248371e-04 -0.0001445145 -1.656929e-04 -0.0001884391
## ASV4497      7.867270e-03  0.0081173843  8.372736e-03  0.0086333316
## ASV6914     -2.218286e-03 -0.0023271070 -2.440348e-03 -0.0025581131
## ASV0576     -2.157767e-02 -0.0220676987 -2.255806e-02 -0.0230483992
## ASV0673      3.138157e-02  0.0324143682  3.347093e-02  0.0345514489
## ASV0772      1.544525e-02  0.0160007339  1.657274e-02  0.0171616520
## ASV0862      5.397633e-03  0.0057080208  6.031370e-03  0.0063678080
## ASV0898      1.435040e-02  0.0149282147  1.552458e-02  0.0161397687
## ASV0910      1.580744e-02  0.0164431139  1.710081e-02  0.0177810802
## ASV0964     -8.579197e-03 -0.0087878549 -8.997516e-03 -0.0092080634
## ASV10059     1.279414e-02  0.0133587264  1.394524e-02  0.0145542671
## ASV10263    -1.851936e-02 -0.0190551385 -1.959805e-02 -0.0201478347
## ASV1088      2.780145e-02  0.0289369380  3.011500e-02  0.0313370248
## ASV1101      2.621501e-02  0.0269727743  2.774137e-02  0.0285205387
## ASV1183      8.506414e-03  0.0088253806  9.154488e-03  0.0094940039
## ASV11956     5.639421e-03  0.0057778995  5.918198e-03  0.0060603919
## ASV12774    -9.183914e-04 -0.0009984124 -1.083065e-03 -0.0011724950
## ASV1321      4.197252e-02  0.0436809539  4.544750e-02  0.0472732355
## ASV13793    -1.277083e-02 -0.0131404125 -1.351491e-02 -0.0138941631
## ASV14482     6.719978e-04  0.0006975796  7.246637e-04  0.0007533503
## ASV15483     6.700129e-03  0.0069562618  7.220162e-03  0.0074919502
## ASV2062      2.737494e-02  0.0283160030  2.928177e-02  0.0302725970
## ASV2132      2.533153e-02  0.0262988297  2.729550e-02  0.0283219385
## ASV2413      1.994451e-02  0.0205903737  2.125150e-02  0.0219281174
## ASV2490      5.432468e-02  0.0558021849  5.729741e-02  0.0588098512
## ASV2594      9.471185e-03  0.0098671436  1.027912e-02  0.0107077386
## ASV2822     -3.369624e-02 -0.0346715910 -3.565995e-02 -0.0366608657
## ASV2863      3.555489e-02  0.0366191393  3.770303e-02  0.0388065587
## ASV2910      1.326614e-02  0.0136694234  1.408041e-02  0.0144991165
## ASV2980      1.632400e-02  0.0168742119  1.743764e-02  0.0180143904
## ASV3307      2.681788e-02  0.0275942060  2.838090e-02  0.0291775944
## ASV3474      2.495730e-02  0.0260027610  2.708551e-02  0.0282063577
## ASV3502      2.224945e-02  0.0230716608  2.391927e-02  0.0247929068
## ASV4236      2.452829e-02  0.0251430969  2.576168e-02  0.0263837092
## ASV4842     -3.120706e-03 -0.0031904946 -3.258030e-03 -0.0033229839
## ASV4894     -1.277342e-02 -0.0131432430 -1.351802e-02 -0.0138975692
## ASV5290      1.256788e-02  0.0130378885  1.352198e-02  0.0140204391
## ASV5501      8.060909e-03  0.0084058199  8.765769e-03  0.0091414275
## ASV5795      8.649264e-03  0.0089791922  9.319039e-03  0.0096689257
## ASV5987     -3.567650e-02 -0.0367095968 -3.775657e-02 -0.0388169423
## ASV6267     -4.020343e-02 -0.0413676795 -4.254759e-02 -0.0437426314
## ASV6862      1.539155e-02  0.0158349062  1.628596e-02  0.0167447474
## ASV7145      6.908143e-03  0.0071332082  7.365160e-03  0.0076042486
## ASV7673     -1.277479e-02 -0.0131448102 -1.351982e-02 -0.0138996593
## ASV7789      1.122360e-02  0.0117792328  1.236016e-02  0.0129672850
## ASV7809      2.043841e-03  0.0021686921  2.299438e-03  0.0024362061
## ASV8002     -1.613543e-02 -0.0166029199 -1.707676e-02 -0.0175567434
## ASV8205      8.450490e-03  0.0087769130  9.113929e-03  0.0094617488
## ASV9155     -3.598086e-03 -0.0036794046 -3.760155e-03 -0.0038402057
## ASV9221      4.840119e-03  0.0051279677  5.430960e-03  0.0057496884
## ASV9311     -2.588833e-02 -0.0266388393 -2.739964e-02 -0.0281704326
## ASV9557     -1.769448e-02 -0.0182075599 -1.872770e-02 -0.0192546926
## ASV9936     -3.568698e-02 -0.0367220076 -3.777133e-02 -0.0388345609
## ASV1445      2.677443e-02  0.0277792545  2.881409e-02  0.0298793860
## ASV4232      1.300954e-02  0.0136404320  1.430187e-02  0.0149952646
## ASV6479      7.465589e-03  0.0078974487  8.352077e-03  0.0088304071
## ASV0142     -1.524085e-02 -0.0156926748 -1.615237e-02 -0.0166198925
## ASV0378      1.024687e-02  0.0106793107  1.112626e-02  0.0115878774
## ASV1122      2.683056e-02  0.0278774397  2.895865e-02  0.0300749364
## ASV0123     -1.332822e-02 -0.0137168750 -1.411177e-02 -0.0145128390
## ASV2064      4.997470e-03  0.0050517312  5.099571e-03  0.0051404593
## ASV4459     -5.144598e-04 -0.0005245074 -5.357540e-04 -0.0005484135
## ASV0448      8.282273e-03  0.0086405877  9.012149e-03  0.0093972575
## ASV0397      1.412585e-02  0.0146148986  1.511626e-02  0.0156300360
## ASV0485      1.567501e-02  0.0161984169  1.673446e-02  0.0172832675
## ASV1566      2.397088e-02  0.0247956455  2.564106e-02  0.0265073019
## ASV1365      2.120619e-02  0.0219427838  2.269645e-02  0.0234670777
## ASV1065      3.047974e-02  0.0315805056  3.271176e-02  0.0338738705
## ASV0722     -2.101532e-03 -0.0022068825 -2.317718e-03 -0.0024343111
## ASV12660    -1.420277e-02 -0.0146072949 -1.501761e-02 -0.0154335954
## ASV0223      4.497381e-03  0.0046578863  4.823259e-03  0.0049936382
## ASV0229      7.889415e-03  0.0082072812  8.536584e-03  0.0088776795
## ASV0877      9.241289e-04  0.0008477918  7.600643e-04  0.0006600552
## ASV0983      1.491784e-02  0.0153823671  1.585544e-02  0.0163369470
## ASV0626      4.216090e-03  0.0044427699  4.679011e-03  0.0049250059
## ASV4146     -1.066674e-04 -0.0001807028 -2.640432e-04 -0.0003574755
## ASV4175     -2.195806e-02 -0.0227858032 -2.363799e-02 -0.0245149180
## ASV2082     -1.630060e-02 -0.0171803411 -1.810388e-02 -0.0190728872
## ASV2272      1.057762e-02  0.0109960519  1.142908e-02  0.0118770904
## ASV2245     -1.601328e-02 -0.0166262934 -1.725779e-02 -0.0179079928
## ASV0590     -1.665689e-02 -0.0175708569 -1.853037e-02 -0.0195371514
## ASV0217      4.534273e-03  0.0048270475  5.134799e-03  0.0054580065
## ASV0416      6.545805e-03  0.0066094700  6.665105e-03  0.0067121621
## ASV1056      1.637540e-02  0.0170307801  1.770718e-02  0.0184048862
## ASV7777     -2.144608e-02 -0.0222904396 -2.316534e-02 -0.0240718872
## ASV0455      3.531898e-03  0.0036499694  3.770294e-03  0.0038927999
## ASV0604      1.132351e-02  0.0117975749  1.228838e-02  0.0127962865
## ASV6100     -1.570726e-02 -0.0163609635 -1.704015e-02 -0.0177457640
## ASV11359    -3.072030e-02 -0.0318326972 -3.297426e-02 -0.0341450470
## ASV6604      4.886601e-03  0.0050861206  5.291989e-03  0.0055042356
## ASV5004     -1.091122e-02 -0.0113240019 -1.175046e-02 -0.0121909953
## ASV1483     -4.444592e-03 -0.0045969353 -4.752884e-03 -0.0049124275
## ASV9773     -1.460051e-02 -0.0151791328 -1.577805e-02 -0.0163978583
## ASV4059      3.018785e-03  0.0032330234  3.458352e-03  0.0036949929
## ASV1193      1.598881e-02  0.0165569965  1.714078e-02  0.0177403864
## ASV4610      7.834432e-04  0.0009029739  1.028486e-03  0.0011599171
## ASV0742      1.500906e-03  0.0016487962  1.804481e-03  0.0019680503
## ASV1502     -2.818725e-03 -0.0029872067 -3.163339e-03 -0.0033472601
## ASV0195     -8.025068e-04 -0.0008712038 -9.438147e-04 -0.0010204608
## ASV1213      8.209246e-03  0.0083912972  8.572421e-03  0.0087523759
## ASV1648     -1.414329e-02 -0.0147387358 -1.535820e-02 -0.0160026248
## ASV6984     -1.339744e-02 -0.0139696322 -1.456545e-02 -0.0151858411
## ASV0396      3.851419e-04  0.0004141680  4.427047e-04  0.0004704349
## ASV4297      1.292094e-02  0.0132599471  1.360217e-02  0.0139475076
## ASV2622      2.264292e-02  0.0233530966  2.407786e-02  0.0248172483
## ASV3512      1.527351e-02  0.0160521653  1.686878e-02  0.0177249404
## ASV2411      2.079588e-02  0.0216636572  2.256210e-02  0.0234918342
## ASV2291     -1.462342e-02 -0.0154118316 -1.623707e-02 -0.0171002643
## ASV0807      2.320899e-02  0.0240016831  2.481294e-02  0.0256427908
## ASV1292      3.622743e-03  0.0036856785  3.747826e-03  0.0038092345
## ASV1035      1.894579e-02  0.0195430319  2.015403e-02  0.0207790335
## ASV0070      1.751419e-03  0.0018754343  2.006675e-03  0.0021454352
## ASV0255      9.730472e-04  0.0009520344  9.258245e-04  0.0008939827
## ASV0057     -4.192487e-03 -0.0042745913 -4.354935e-03 -0.0044332982
## ASV0077     -4.004529e-04 -0.0003877769 -3.738166e-04 -0.0003586002
## ASV0625      1.008855e-02  0.0103620234  1.063837e-02  0.0109174542
## ASV2464      6.920839e-02  0.0711636223  7.314733e-02  0.0751590798
## ASV1315      2.760857e-02  0.0287784387  2.999074e-02  0.0312464238
## ASV2673      2.387635e-02  0.0248992351  2.596045e-02  0.0270610082
## ASV2161      1.016281e-02  0.0106104531  1.107635e-02  0.0115611081
## ASV0337     -5.116637e-03 -0.0053161567 -5.522316e-03 -0.0057352789
## ASV7680     -3.420179e-02 -0.0355553281 -3.695401e-02 -0.0383987875
## ASV0611      1.939225e-02  0.0201816125  2.099950e-02  0.0218467432
## ASV3118     -2.227794e-02 -0.0232368159 -2.423141e-02 -0.0252626217
## ASV1284     -3.722072e-03 -0.0042686183 -4.858178e-03 -0.0054931092
## ASV0889      1.216227e-02  0.0125846535  1.301960e-02  0.0134675327
## ASV4649     -6.823163e-03 -0.0070819054 -7.348978e-03 -0.0076245827
## ASV1108     -1.791877e-02 -0.0187389774 -1.959287e-02 -0.0204814486
## ASV0738      1.230682e-02  0.0129498101  1.362431e-02  0.0143316140
## ASV0473     -2.790988e-03 -0.0029173755 -3.046675e-03 -0.0031786359
## ASV0598     -7.252364e-03 -0.0076601877 -8.089404e-03 -0.0085409154
## ASV0429      7.778939e-03  0.0079801061  8.181839e-03  0.0083838831
## ASV1549      2.219454e-02  0.0231467573  2.413410e-02  0.0251573448
## ASV1203      1.306898e-02  0.0134910603  1.392170e-02  0.0143608260
## ASV4532      2.052691e-04  0.0002117878  2.196449e-04  0.0002290480
## ASV0274      3.277511e-03  0.0034097824  3.545191e-03  0.0036835978
## ASV0163     -8.896661e-03 -0.0091586819 -9.426244e-03 -0.0096995011
## ASV1298      9.579556e-04  0.0010121213  1.071505e-03  0.0011366222
## ASV9424     -2.766997e-02 -0.0288313893 -3.003766e-02 -0.0312902862
## ASV0412      2.216441e-02  0.0228730795  2.359664e-02  0.0243350914
## ASV0284      2.305950e-03  0.0022757964  2.237271e-03  0.0021897753
## ASV0620     -8.215649e-03 -0.0086280954 -9.058995e-03 -0.0095089498
## ASV0153     -2.927691e-02 -0.0305112452 -3.178930e-02 -0.0331119391
## ASV0498      8.949772e-03  0.0092642403  9.585035e-03  0.0099119212
## ASV0097      5.832928e-03  0.0060833371  6.342981e-03  0.0066120621
## ASV0104     -3.176238e-02 -0.0328194671 -3.389937e-02 -0.0350019499
## ASV1282      8.619657e-03  0.0087936145  8.962032e-03  0.0091240941
## ASV3883     -1.270045e-02 -0.0132697727 -1.385988e-02 -0.0144710930
## ASV0801      5.117330e-03  0.0053315209  5.554657e-03  0.0057871637
## ASV1611     -2.551425e-02 -0.0265900499 -2.770575e-02 -0.0288623938
## ASV0227     -6.956393e-03 -0.0073197739 -7.699984e-03 -0.0080975949
## ASV0833      7.742431e-03  0.0080326957  8.331482e-03  0.0086389120
## ASV0718      3.463940e-02  0.0359569144  3.731505e-02  0.0387145023
## ASV1139      3.263672e-04  0.0001865825  3.361721e-05 -0.0001331671
## ASV0766     -6.361124e-03 -0.0066472988 -6.944079e-03 -0.0072516490
## ASV2091      2.098652e-02  0.0215354046  2.208764e-02  0.0226427242
## ASV1238     -2.907823e-02 -0.0303663474 -3.171069e-02 -0.0331136766
## ASV9193     -6.401050e-03 -0.0068038313 -7.229777e-03 -0.0076799416
## ASV0290      1.717434e-03  0.0017398761  1.762824e-03  0.0017865025
## ASV0231      8.537941e-03  0.0087926825  9.050568e-03  0.0093113468
## ASV0185      9.305156e-03  0.0097872056  1.029245e-02  0.0108217908
## ASV2330      8.191747e-03  0.0083925729  8.594971e-03  0.0087989384
## ASV3119     -8.140127e-03 -0.0085518081 -8.982655e-03 -0.0094333762
## ASV2368     -1.627182e-02 -0.0170335284 -1.782995e-02 -0.0186625356
## ASV0122     -5.652809e-03 -0.0058428389 -6.037447e-03 -0.0062366742
## ASV1044      1.844988e-02  0.0192360227  2.005243e-02  0.0209000555
## ASV0160     -4.935378e-03 -0.0050681943 -5.203321e-03 -0.0053408666
## ASV0326      1.701491e-03  0.0017553205  1.809589e-03  0.0018641844
## ASV1388      2.952472e-02  0.0305060840  3.150909e-02  0.0325336758
## ASV0792      1.965033e-02  0.0202211172  2.079976e-02  0.0213860051
## ASV0036     -8.681863e-03 -0.0090382841 -9.406222e-03 -0.0097857836
## ASV2125      2.176692e-02  0.0225113165  2.327287e-02  0.0240515000
## ASV1075     -5.205323e-04 -0.0005539211 -5.897828e-04 -0.0006282929
## ASV0390      1.515555e-02  0.0158427046  1.655941e-02  0.0173067877
## ASV3790     -1.873332e-02 -0.0194779168 -2.024791e-02 -0.0210439125
## ASV1535     -7.459641e-03 -0.0078212096 -8.197942e-03 -0.0085902182
## ASV0263      2.144840e-02  0.0222428643  2.306068e-02  0.0239022017
## ASV0675      3.577106e-02  0.0372322465  3.874476e-02  0.0403098161
## ASV3348      3.438256e-03  0.0035921071  3.751613e-03  0.0039168628
## ASV0058     -8.592728e-03 -0.0088713218 -9.155466e-03 -0.0094450952
## ASV4142      1.070722e-02  0.0110110126  1.131930e-02  0.0116320654
## ASV0059     -6.680436e-03 -0.0068873745 -7.097832e-03 -0.0073117302
## ASV0013     -1.344987e-02 -0.0139376761 -1.443913e-02 -0.0149544117
## ASV0033     -7.494720e-03 -0.0078028668 -8.121208e-03 -0.0084498757
## ASV4354     -8.430082e-03 -0.0087679256 -9.117866e-03 -0.0094802185
## ASV0022     -6.353460e-03 -0.0066174359 -6.890463e-03 -0.0071726919
## ASV0134     -7.079996e-03 -0.0074211680 -7.778201e-03 -0.0081517872
## ASV0415      1.418515e-03  0.0014832055  1.549957e-03  0.0016187716
## ASV10103    -3.400581e-02 -0.0354001907 -3.684368e-02 -0.0383374067
## ASV1613      1.832760e-02  0.0188285526  1.933249e-02  0.0198387820
## ASV0135     -1.931482e-03 -0.0019674037 -2.002364e-03 -0.0020362587
## ASV0469     -2.663958e-02 -0.0275542331 -2.849373e-02 -0.0294585753
## ASV0471      1.750391e-02  0.0181492484  1.881467e-02  0.0195007255
## ASV0451     -5.506469e-03 -0.0057999247 -6.106618e-03 -0.0064268965
## ASV0747      1.033809e-02  0.0107182248  1.110848e-02  0.0115088681
## ASV1314     -1.275300e-02 -0.0133366150 -1.394538e-02 -0.0145802136
## ASV0425     -2.914454e-02 -0.0299835106 -3.083514e-02 -0.0316992740
## ASV0559     -9.245765e-03 -0.0096292221 -1.002880e-02 -0.0104452037
## ASV0148      3.285782e-05  0.0001173489  2.098489e-04  0.0003108192
## ASV0129      5.947999e-03  0.0063234860  6.720177e-03  0.0071389882
## ASV1072      9.853918e-04  0.0009636441  9.375085e-04  0.0009067223
## ASV2390      1.266661e-02  0.0129064754  1.313940e-02  0.0133645974
## ASV0548      1.165885e-02  0.0120627686  1.247657e-02  0.0129002872
## ASV0168     -5.581620e-03 -0.0057645966 -5.951819e-03 -0.0061433269
## ASV0066     -6.315488e-03 -0.0065125184 -6.712484e-03 -0.0069152193
## ASV0468     -3.919577e-03 -0.0040754689 -4.237077e-03 -0.0044046041
## ASV0172     -8.826123e-04 -0.0008663472 -8.464764e-04 -0.0008227666
## ASV0236      4.172918e-03  0.0044950753  4.836340e-03  0.0051974390
## ASV0250      1.439827e-02  0.0151142732  1.586396e-02  0.0166486680
## ASV0338      5.198983e-03  0.0053899033  5.584988e-03  0.0057841076
## ASV0450     -1.931076e-03 -0.0020442750 -2.163549e-03 -0.0022891529
## ASV0377      7.865975e-03  0.0081121638  8.362137e-03  0.0086156910
## ASV1022      7.299668e-05  0.0001035644  1.376691e-04  0.0001756023
## ASV6174     -8.279735e-04 -0.0008813716 -9.370346e-04 -0.0009948874
## ASV0786     -2.827519e-03 -0.0029776928 -3.133764e-03 -0.0032957581
## ASV0053     -9.623217e-03 -0.0099769819 -1.034073e-02 -0.0107145622
## ASV0697     -4.968319e-03 -0.0051285515 -5.292872e-03 -0.0054614103
## ASV0785      1.106967e-02  0.0114348292  1.180834e-02  0.0121902649
## ASV1967     -1.091749e-02 -0.0112844048 -1.166037e-02 -0.0120454591
## ASV0385      4.812289e-03  0.0050018520  5.196314e-03  0.0053955654
## ASV0295      2.241077e-03  0.0023846837  2.536473e-03  0.0026968018
## ASV0072     -7.796060e-03 -0.0080103236 -8.225739e-03 -0.0084420037
## ASV0157      1.176642e-03  0.0013208682  1.476305e-03  0.0016435741
## ASV0501      2.097238e-02  0.0217361788  2.251958e-02  0.0233225344
## ASV10729    -2.772926e-02 -0.0288192436 -2.994507e-02 -0.0311074800
## ASV1470      8.923508e-03  0.0090887330  9.248455e-03  0.0094019908
## ASV0050     -2.037806e-02 -0.0210446152 -2.172484e-02 -0.0224185966
## ASV0411     -5.934087e-03 -0.0061915216 -6.459457e-03 -0.0067382997
## ASV0549      8.925319e-03  0.0092816298  9.649664e-03  0.0100296323
## ASV0184      2.723034e-03  0.0028324676  2.946400e-03  0.0030650497
## ASV0705      4.344565e-03  0.0044584733  4.572242e-03  0.0046856170
## ASV1715      1.138914e-02  0.0118063322  1.223523e-02  0.0126759514
## ASV0603      2.357983e-03  0.0024810178  2.611035e-03  0.0027484370
## ASV0826      1.825180e-02  0.0188948678  1.955544e-02  0.0202338040
## ASV0034     -5.201912e-03 -0.0053559941 -5.512169e-03 -0.0056703420
## ASV0838     -1.673158e-03 -0.0020055926 -2.368441e-03 -0.0027637166
## ASV0614     -4.964656e-03 -0.0051378795 -5.315646e-03 -0.0054980134
## ASV0014     -1.335149e-02 -0.0138181964 -1.429664e-02 -0.0147868685
## ASV0585     -2.102849e-03 -0.0023056655 -2.520481e-03 -0.0027475872
## ASV0016     -1.396658e-02 -0.0144556575 -1.495712e-02 -0.0154710265
## ASV5394     -1.115228e-02 -0.0115648326 -1.198854e-02 -0.0124233806
## ASV0666      1.957175e-02  0.0201422575  2.072101e-02  0.0213078042
## ASV2085     -6.407537e-04 -0.0008869096 -1.153369e-03 -0.0014411270
## ASV0003     -9.502230e-03 -0.0098346902 -1.017561e-02 -0.0105250525
## ASV0346      5.790952e-03  0.0060223992  6.260622e-03  0.0065056218
## ASV0267      1.064384e-03  0.0011328777  1.203625e-03  0.0012764728
## ASV0353      9.047137e-03  0.0094221940  9.810585e-03  0.0102126191
## ASV2419      1.964790e-02  0.0203027136  2.097156e-02  0.0216542593
## ASV0447      1.329605e-02  0.0138444324  1.441212e-02  0.0149995928
## ASV0654      1.655460e-02  0.0171290148  1.771719e-02  0.0183191047
## ASV0151      3.808186e-03  0.0040068275  4.214648e-03  0.0044319229
## ASV0065     -6.122661e-03 -0.0063268958 -6.535747e-03 -0.0067492207
## ASV0527      1.558639e-02  0.0161276487  1.668230e-02  0.0172503826
## ASV4055     -4.060319e-03 -0.0042899300 -4.533414e-03 -0.0047916285
## ASV0166     -6.764869e-03 -0.0069606435 -7.159169e-03 -0.0073603867
## ASV0417     -2.037008e-03 -0.0020634928 -2.088005e-03 -0.0021104067
## ASV0078     -4.004544e-03 -0.0041117150 -4.218917e-03 -0.0043259255
## ASV0322      9.649815e-04  0.0010939729  1.233867e-03  0.0013852949
## ASV0156     -1.259664e-02 -0.0131077008 -1.363729e-02 -0.0141859831
## ASV0648     -2.761466e-02 -0.0287234076 -2.986953e-02 -0.0310537618
## ASV0407     -2.433566e-03 -0.0025486011 -2.668925e-03 -0.0027947563
## ASV2030     -4.574036e-03 -0.0047903911 -5.018139e-03 -0.0052578774
## ASV0300      3.600721e-03  0.0037523994  3.909293e-03  0.0040714803
## ASV1150      1.081374e-03  0.0011318449  1.183939e-03  0.0012376290
## ASV0958      1.174685e-02  0.0122855001  1.284726e-02  0.0134329762
## ASV0216     -9.851682e-03 -0.0102268915 -1.061615e-02 -0.0110200542
## ASV0446      1.677565e-02  0.0174306664  1.810605e-02  0.0188020767
## ASV0367     -1.053006e-02 -0.0109316500 -1.134567e-02 -0.0117723325
## ASV0200     -6.113340e-03 -0.0063355958 -6.563533e-03 -0.0067971205
## ASV0334     -1.533844e-03 -0.0015448134 -1.555078e-03 -0.0015647499
## ASV1311      2.092098e-03  0.0020946520  2.092515e-03  0.0020853464
## ASV0458      3.025673e-03  0.0030389336  3.047188e-03  0.0030501265
## ASV1371      1.219967e-03  0.0012665547  1.313865e-03  0.0013618025
## ASV0418      1.092766e-02  0.0112429084  1.156268e-02  0.0118868567
## ASV0004      1.510387e-03  0.0015506654  1.591292e-03  0.0016322386
## ASV1943      1.979795e-02  0.0200261619  2.023918e-02  0.0204362281
## ASV1495     -6.408378e-03 -0.0067940879 -7.200732e-03 -0.0076291728
## ASV0901     -1.322634e-02 -0.0137979416 -1.439271e-02 -0.0150114675
## ASV0628      3.907117e-03  0.0039646897  4.018309e-03  0.0040675788
## ASV0400      2.879928e-03  0.0029452490  3.009043e-03  0.0030709962
## ASV0116     -3.810935e-03 -0.0039709185 -4.136940e-03 -0.0043091812
## ASV0788      3.422443e-02  0.0356874048  3.720801e-02  0.0387882348
## ASV0117      2.817855e-03  0.0029447543  3.076667e-03  0.0032137291
## ASV3137     -5.608385e-04 -0.0005742919 -5.874196e-04 -0.0006001362
## ASV0001      1.562722e-03  0.0016015824  1.640614e-03  0.0016797934
## ASV1651      4.774620e-03  0.0049104268  5.048314e-03  0.0051882885
## ASV1692      2.795969e-02  0.0291238873  3.033128e-02  0.0315831629
## ASV0660      5.000590e-03  0.0050275487  5.044946e-03  0.0050520545
## ASV0508      2.235277e-04  0.0002228462  2.214148e-04  0.0002191497
## ASV1660     -6.819793e-03 -0.0071271654 -7.445699e-03 -0.0077755404
## ASV0233      7.821681e-03  0.0081176527  8.422785e-03  0.0087372578
## ASV1343     -1.578749e-02 -0.0164451991 -1.712770e-02 -0.0178357634
## ASV0209      5.250035e-03  0.0053774863  5.504616e-03  0.0056311932
## ASV0193     -6.311003e-03 -0.0064662373 -6.620803e-03 -0.0067743723
## ASV0357      5.473896e-03  0.0057808769  6.104590e-03  0.0064458305
## ASV0198      5.741482e-03  0.0059420184  6.148389e-03  0.0063607505
## ASV0007      1.245624e-03  0.0012703365  1.294681e-03  0.0013186226
## ASV1772     -6.496085e-04 -0.0005516321 -4.392225e-04 -0.0003110521
## ASV0009      9.135331e-04  0.0009260033  9.377892e-04  0.0009488580
## ASV0006     -2.108264e-03 -0.0022018035 -2.298938e-03 -0.0023997541
## ASV0011     -6.293720e-03 -0.0065446557 -6.804111e-03 -0.0070722859
## ASV0015      6.581435e-04  0.0006640735  6.691073e-04  0.0006731795
## ASV0017      7.793520e-04  0.0007898147  7.995938e-04  0.0008086375
## ASV0235     -5.950008e-03 -0.0061928161 -6.444409e-03 -0.0067050531
## ASV0382      4.164973e-03  0.0042930726  4.421230e-03  0.0045490317
## ASV2357      1.904399e-02  0.0198148319  2.061305e-02  0.0214393779
## ASV0567     -4.112348e-03 -0.0043053589 -4.507687e-03 -0.0047197847
## ASV0165      3.074239e-03  0.0031908198  3.310794e-03  0.0034341958
## ASV0005      4.008703e-03  0.0041446229  4.283532e-03  0.0044254018
## ASV0384      7.578335e-04  0.0008385633  9.254672e-04  0.0010189069
## ASV0002      6.755511e-04  0.0006975754  7.201597e-04  0.0007433136
## ASV3017      1.769591e-02  0.0181710489  1.864963e-02  0.0191312311
## ASV0091     -6.119968e-04 -0.0006421582 -6.742100e-04 -0.0007082959
## ASV0186     -8.258793e-03 -0.0085415559 -8.830285e-03 -0.0091248601
## ASV0370      4.062200e-03  0.0041958783  4.332841e-03  0.0044731635
## ASV0018      5.242630e-03  0.0054254605  5.612729e-03  0.0058044344
## ASV1377      4.538193e-02  0.0467176734  4.807261e-02  0.0494461450
## ASV0019      5.544760e-03  0.0057403292  5.940835e-03  0.0061462955
## ASV0023     -3.937734e-03 -0.0040941315 -4.255442e-03 -0.0044217214
## ASV2194      6.994734e-03  0.0073094655  7.637463e-03  0.0079791942
## ASV1155      1.978811e-02  0.0204512398  2.113243e-02  0.0218321455
## ASV0510     -3.945171e-03 -0.0040290911 -4.113725e-03 -0.0041991825
## ASV2371     -1.166554e-02 -0.0120304249 -1.240225e-02 -0.0127809144
## ASV0024     -4.853427e-03 -0.0050451203 -5.242846e-03 -0.0054466789
## ASV2452      9.168373e-03  0.0093338167  9.494170e-03  0.0096489372
## ASV2332     -3.557056e-02 -0.0367903608 -3.804306e-02 -0.0393292154
## ASV2591      1.421310e-02  0.0148190193  1.544338e-02  0.0160861702
## ASV0521      9.973987e-03  0.0103803545  1.080108e-02  0.0112365416
## ASV5542      9.240854e-03  0.0095968137  9.963984e-03  0.0103426000
## ASV0336     -2.314135e-03 -0.0024436995 -2.579787e-03 -0.0027226780
## ASV10102     1.712536e-02  0.0177854737  1.846529e-02  0.0191650265
## ASV16823    -1.875856e-02 -0.0192794411 -1.980782e-02 -0.0203436008
## ASV3104      9.705911e-02  0.0997539923  1.024876e-01  0.1052595121
## ASV0781      1.738757e-02  0.0180255427  1.868327e-02  0.0193612585
## ASV10899     1.624189e-02  0.0170586160  1.791270e-02  0.0188054809
## ASV11222    -3.301634e-02 -0.0339329552 -3.486275e-02 -0.0358055244
## ASV11327    -2.964231e-02 -0.0304651908 -3.129989e-02 -0.0321462370
## ASV12458    -3.301517e-02 -0.0339316146 -3.486121e-02 -0.0358037706
## ASV1636      2.124796e-02  0.0219218737  2.261001e-02  0.0233124106
## ASV1890     -1.269351e-02 -0.0129698894 -1.324767e-02 -0.0135269404
## ASV2898      2.865620e-02  0.0295714147  3.050631e-02  0.0314610159
## ASV8328      1.314946e-02  0.0139729277  1.484057e-02  0.0157540829
## ASV0709     -3.372071e-02 -0.0348440128 -3.599245e-02 -0.0371660136
## ASV0856      3.541232e-02  0.0368874219  3.841397e-02  0.0399929922
## ASV0909      1.617924e-02  0.0170448245  1.795083e-02  0.0188985499
## ASV0937     -2.431954e-02 -0.0253662973 -2.645580e-02 -0.0275895934
## ASV11390    -4.711802e-02 -0.0484256623 -4.975204e-02 -0.0510968745
## ASV11966     1.854275e-02  0.0193370013  2.015898e-02  0.0210091480
## ASV12990     8.873176e-03  0.0091354104  9.402498e-03  0.0096744916
## ASV14797     1.274164e-02  0.0131090893  1.348283e-02  0.0138628928
## ASV14904    -6.761177e-02 -0.0694879776 -7.139104e-02 -0.0733205584
## ASV15304     1.312390e-02  0.0137219523  1.434225e-02  0.0149851786
## ASV16696    -2.336077e-02 -0.0240089805 -2.466647e-02 -0.0253330937
## ASV1690      5.855080e-02  0.0608494274  6.321449e-02  0.0656461950
## ASV2029      3.335230e-02  0.0345024350  3.568262e-02  0.0368932426
## ASV2834      4.684005e-02  0.0486014684  5.041318e-02  0.0522755973
## ASV4003      4.954159e-02  0.0519248559  5.441945e-02  0.0570301827
## ASV4064      2.291337e-02  0.0238043847  2.472372e-02  0.0256719527
## ASV4294      1.912537e-02  0.0200713163  2.106024e-02  0.0220937061
## ASV4609      1.133181e-02  0.0117383240  1.215792e-02  0.0125910154
## ASV6283     -2.183682e-02 -0.0224426943 -2.305723e-02 -0.0236802994
## ASV6491     -3.129860e-02 -0.0321669666 -3.304774e-02 -0.0339407529
## ASV7453      2.522444e-02  0.0263261646  2.746770e-02  0.0286497958
## ASV7959      1.259208e-02  0.0132568886  1.395335e-02  0.0146826669
## ASV8219      2.704843e-01  0.2779884692  2.855999e-01  0.2933169800
## ASV8547     -2.802126e-02 -0.0287986534 -2.958716e-02 -0.0303866085
## ASV9319      1.865707e-02  0.0194597638  2.029420e-02  0.0211614589
## ASV9382     -5.482706e-02 -0.0563480964 -5.789088e-02 -0.0594550868
## ASV11516    -3.661990e-02 -0.0376358191 -3.866626e-02 -0.0397110258
## ASV14377    -2.644145e-02 -0.0271749906 -2.791903e-02 -0.0286734028
## ASV1867      2.909871e-02  0.0302645712  3.147081e-02  0.0327185187
## ASV1895      8.519452e-03  0.0086329455  8.737263e-03  0.0088316480
## ASV3168      1.287998e-02  0.0132032513  1.352759e-02  0.0138527023
## ASV4449      9.261256e-02  0.0961103568  9.972210e-02  0.1034507673
## ASV6596      2.692108e-02  0.0282207426  2.957856e-02  0.0309965964
## ASV7492      2.891675e-03  0.0032130908  3.555155e-03  0.0039186289
## ASV9854     -5.403702e-03 -0.0055471099 -5.692123e-03 -0.0058386714
## ASV6296      4.437035e-01  0.4560130355  4.684987e-01  0.4811579511
## ASV4201      1.013989e-02  0.0107952566  1.148779e-02  0.0122191520
## ASV0552      1.954340e-02  0.0202906665  2.106002e-02  0.0218516412
## ASV3671     -1.256300e-02 -0.0130906511 -1.364176e-02 -0.0142174828
## ASV3529      1.217103e-03  0.0013787304  1.548710e-03  0.0017270809
## ASV1060      6.291969e-03  0.0065919399  6.906148e-03  0.0072352388
## ASV0239     -4.567954e-03 -0.0046669774 -4.765314e-03 -0.0048628027
## ASV5711     -2.742840e-02 -0.0283680237 -2.933209e-02 -0.0303208640
## ASV4152     -4.329659e-02 -0.0449141154 -4.657844e-02 -0.0482899874
## ASV1461      1.521987e-02  0.0155674095  1.591426e-02  0.0162600607
## ASV2877      8.201377e-03  0.0083914377  8.580245e-03  0.0087674143
## ASV0012      1.929540e-03  0.0020018873  2.076479e-03  0.0021533583
## ASV9823     -1.391204e-04 -0.0002697688 -4.129151e-04 -0.0005692784
## ASV0008      2.012301e-03  0.0020865879  2.163151e-03  0.0022420374
## ASV7832     -2.677500e-02 -0.0278415769 -2.894428e-02 -0.0300838755
## ASV1915     -3.154808e-03 -0.0032907512 -3.433050e-03 -0.0035819995
## ASV0055     -3.306059e-03 -0.0034705879 -3.642625e-03 -0.0038224434
## ASV0032      4.232071e-04  0.0004204122  4.169034e-04  0.0004127004
## ASV2977     -3.520572e-02 -0.0364882184 -3.780536e-02 -0.0391572775
## ASV0466      2.016097e-02  0.0206082370  2.105204e-02  0.0214916230
## ASV3866      2.209671e-02  0.0230315188  2.400265e-02  0.0250113152
## ASV0040      7.317499e-03  0.0075988036  7.888949e-03  0.0081880902
## ASV0496     -5.071089e-03 -0.0053794576 -5.703267e-03 -0.0060429695
## ASV0052      6.187111e-03  0.0064278488  6.676577e-03  0.0069335020
## ASV3828     -1.551998e-02 -0.0159405692 -1.636642e-02 -0.0167973851
## ASV1930      8.391176e-03  0.0086126450  8.835214e-03  0.0090586672
## ASV2126      1.677072e-02  0.0173580947  1.796192e-02  0.0185825291
## ASV0793      2.413773e-02  0.0251076095  2.611077e-02  0.0271480276
## ASV0299     -1.130938e-03 -0.0012233565 -1.323523e-03 -0.0014320056
## ASV0208      1.674249e-02  0.0174054232  1.809167e-02  0.0188019190
## ASV0511     -4.349733e-03 -0.0044436829 -4.538090e-03 -0.0046330271
## ASV1123     -1.420127e-02 -0.0145371757 -1.487256e-02 -0.0152068525
## ASV0099      1.202450e-03  0.0012763113  1.354535e-03  0.0014373326
## ASV0752     -1.366984e-02 -0.0142658573 -1.488529e-02 -0.0155288706
## ASV0883      1.815531e-02  0.0189082435  1.968658e-02  0.0204907052
## ASV0683      2.308967e-02  0.0240474977  2.503971e-02  0.0260671472
## ASV4117     -3.437772e-02 -0.0357564724 -3.718418e-02 -0.0386622053
## ASV2172      4.386052e-04  0.0003856958  3.265035e-04  0.0002606195
## ASV0330     -6.611320e-03 -0.0068825993 -7.164021e-03 -0.0074559225
## ASV0728      2.899380e-02  0.0300271451  3.108882e-02  0.0321792448
## ASV0499      9.225784e-03  0.0096189224  1.002687e-02  0.0104500337
## ASV0120     -1.287256e-02 -0.0133216977 -1.378142e-02 -0.0142516543
## ASV1446      4.146487e-03  0.0040730340  3.983128e-03  0.0038756576
## ASV17171    -2.606668e-02 -0.0270861982 -2.814161e-02 -0.0292339942
## ASV0533      2.600314e-03  0.0027215750  2.847769e-03  0.0029790226
## ASV2495     -1.018746e-02 -0.0107186915 -1.127444e-02 -0.0118554432
## ASV5582      6.512914e-03  0.0065661281  6.610286e-03  0.0066446853
## ASV1488      3.393481e-03  0.0034629440  3.530022e-03  0.0035943550
## ASV0682      6.809496e-03  0.0070984704  7.397875e-03  0.0077079313
## ASV0068     -9.940972e-03 -0.0102914405 -1.064997e-02 -0.0110164354
## ASV1987     -3.043953e-02 -0.0317638166 -3.313842e-02 -0.0345646767
## ASV0035     -4.583381e-03 -0.0048786445 -5.192043e-03 -0.0055245373
## ASV7192     -1.387772e-02 -0.0143253644 -1.478156e-02 -0.0152461019
## ASV0873     -3.454511e-02 -0.0368021039 -3.916722e-02 -0.0416429203
## ASV4749     -7.512203e-03 -0.0080522028 -8.623311e-03 -0.0092267271
## ASV2174      6.271544e-03  0.0063341748  6.388833e-03  0.0064349416
## ASV1476     -1.348934e-02 -0.0140913452 -1.471773e-02 -0.0153692332
## ASV0740     -3.704504e-02 -0.0386503295 -4.031928e-02 -0.0420540149
## ASV0170     -6.335799e-03 -0.0065794592 -6.831131e-03 -0.0070910187
## ASV2466     -2.945093e-02 -0.0306143040 -3.181774e-02 -0.0330622680
## ASV1709      1.009152e-02  0.0105254976  1.098155e-02  0.0114610959
## ASV6170     -4.908970e-02 -0.0511097934 -5.320211e-02 -0.0553684390
## ASV3673      2.519976e-02  0.0262706351  2.738122e-02  0.0285325114
## ASV1745     -7.601923e-03 -0.0079597151 -8.332543e-03 -0.0087208539
##                                                                    
## (Intercept)  0.1706553926  1.765528e-01  1.825919e-01  1.887728e-01
## ASV1236      0.0284491953  2.930428e-02  3.017546e-02  3.106266e-02
## ASV0421      0.0074615663  7.825794e-03  8.203195e-03  8.593857e-03
## ASV0691     -0.0146330149 -1.484620e-02 -1.505411e-02 -1.525657e-02
## ASV0899      0.0239851264  2.464636e-02  2.531554e-02  2.599246e-02
## ASV1004      0.0567777907  5.844264e-02  6.013529e-02  6.185549e-02
## ASV1041     -0.0210194121 -2.148986e-02 -2.195560e-02 -2.241569e-02
## ASV1058      0.0356185776  3.668738e-02  3.777660e-02  3.888626e-02
## ASV12542     0.0124504289  1.279397e-02  1.314414e-02  1.350114e-02
## ASV1294      0.0335116457  3.453870e-02  3.558755e-02  3.665844e-02
## ASV13113     0.0176063372  1.841091e-02  1.924932e-02  2.012272e-02
## ASV1318      0.0328923423  3.386666e-02  3.485875e-02  3.586867e-02
## ASV2269     -0.0546898642 -5.616760e-02 -5.765911e-02 -5.916335e-02
## ASV2542      0.0374882938  3.900183e-02  4.056874e-02  4.219043e-02
## ASV2660     -0.0214641592 -2.204931e-02 -2.264168e-02 -2.324108e-02
## ASV2737      0.0062878760  6.442315e-03  6.599509e-03  6.759590e-03
## ASV2840      0.0242977339  2.478828e-02  2.527441e-02  2.575554e-02
## ASV3053      0.1418102507  1.456821e-01  1.496151e-01  1.536093e-01
## ASV3077      0.0094399595  9.719935e-03  1.000615e-02  1.029876e-02
## ASV3134      0.0262723387  2.742432e-02  2.862256e-02  2.986856e-02
## ASV3140      0.0284421910  2.943632e-02  3.045524e-02  3.149904e-02
## ASV3579      0.0146960211  1.537406e-02  1.607838e-02  1.680950e-02
## ASV6119     -0.0149587469 -1.536250e-02 -1.577008e-02 -1.618124e-02
## ASV7557     -0.0303970010 -3.121745e-02 -3.204573e-02 -3.288136e-02
## ASV8422      0.0074254973  7.645222e-03  7.870192e-03  8.100570e-03
## ASV1086     -0.0008643708 -8.897705e-04 -9.165377e-04 -9.447714e-04
## ASV1310      0.0148650394  1.528495e-02  1.571045e-02  1.614136e-02
## ASV15750    -0.0012307669 -1.230771e-03 -1.228309e-03 -1.223248e-03
## ASV16905    -0.0062499272 -6.418738e-03 -6.589209e-03 -6.761250e-03
## ASV2033      0.0380699264  3.956710e-02  4.111165e-02  4.270442e-02
## ASV2089      0.0132137427  1.357055e-02  1.393078e-02  1.429424e-02
## ASV2127      0.0444189579  4.573067e-02  4.706604e-02  4.842506e-02
## ASV2725      0.0325826851  3.343556e-02  3.429739e-02  3.516785e-02
## ASV2804     -0.0129383889 -1.328810e-02 -1.364131e-02 -1.399785e-02
## ASV3075      0.0362873607  3.769217e-02  3.914706e-02  4.065360e-02
## ASV3327      0.0529472207  5.495864e-02  5.703127e-02  5.916615e-02
## ASV3342      0.0447802483  4.648629e-02  4.824662e-02  5.006242e-02
## ASV3532     -0.0476500680 -4.945639e-02 -5.132427e-02 -5.325576e-02
## ASV3600      0.0222561898  2.307917e-02  2.392650e-02  2.479854e-02
## ASV4013      0.0363656955  3.752151e-02  3.870035e-02  3.990199e-02
## ASV4136      0.0342467148  3.523231e-02  3.623552e-02  3.725641e-02
## ASV4195      0.1320920675  1.356660e-01  1.392766e-01  1.429221e-01
## ASV4407     -0.0510398290 -5.242120e-02 -5.381680e-02 -5.522598e-02
## ASV4717      0.0068787394  7.034384e-03  7.192784e-03  7.354134e-03
## ASV6794      0.0198021273  2.035738e-02  2.092394e-02  2.150205e-02
## ASV8324     -0.0261919924 -2.690142e-02 -2.761825e-02 -2.834216e-02
## ASV8981      0.0015767733  1.717581e-03  1.866955e-03  2.025190e-03
## ASV9859      0.0187294928  1.970650e-02  2.073210e-02  2.180839e-02
## ASV0936      0.0327447958  3.390769e-02  3.509954e-02  3.632040e-02
## ASV12683    -0.0003723334 -3.798983e-04 -3.862644e-04 -3.912798e-04
## ASV1293      0.0170470797  1.752353e-02  1.800661e-02  1.849623e-02
## ASV13055     0.0011421513  1.240547e-03  1.344808e-03  1.455140e-03
## ASV17063    -0.0135955276 -1.396420e-02 -1.433677e-02 -1.471306e-02
## ASV2228      0.0110884113  1.138916e-02  1.169310e-02  1.200008e-02
## ASV2769      0.0036727261  3.837167e-03  4.006419e-03  4.180400e-03
## ASV2803      0.0102369823  1.047746e-02  1.072005e-02  1.096478e-02
## ASV2896      0.0141688908  1.478814e-02  1.543374e-02  1.610673e-02
## ASV3062      0.0193700147  2.021736e-02  2.109512e-02  2.200382e-02
## ASV3107      0.0242614779  2.521402e-02  2.619864e-02  2.721609e-02
## ASV3265      0.0239812922  2.463608e-02  2.529909e-02  2.597010e-02
## ASV3666     -0.0002128208 -2.389053e-04 -2.667592e-04 -2.964462e-04
## ASV4497      0.0088991729  9.170261e-03  9.446594e-03  9.728171e-03
## ASV6914     -0.0026805039 -2.807621e-03 -2.939560e-03 -3.076413e-03
## ASV0576     -0.0235383378 -2.402752e-02 -2.451559e-02 -2.500219e-02
## ASV0673      0.0356561439  3.678522e-02  3.793891e-02  3.911743e-02
## ASV0772      0.0177678578  1.839175e-02  1.903375e-02  1.969425e-02
## ASV0862      0.0067174351  7.080321e-03  7.456501e-03  7.845980e-03
## ASV0898      0.0167740736  1.742776e-02  1.810109e-02  1.879432e-02
## ASV0910      0.0184844479  1.921146e-02  1.996264e-02  2.073853e-02
## ASV0964     -0.0094193855 -9.631376e-03 -9.843936e-03 -1.005698e-02
## ASV10059     0.0151863794  1.584215e-02  1.652215e-02  1.722692e-02
## ASV10263    -0.0207042319 -2.126697e-02 -2.183578e-02 -2.241035e-02
## ASV1088      0.0326044256  3.391865e-02  3.528116e-02  3.669346e-02
## ASV1101      0.0293100346  3.010960e-02  3.091898e-02  3.173791e-02
## ASV1183      0.0098442004  1.020536e-02  1.057777e-02  1.096172e-02
## ASV11956     0.0062045667  6.350820e-03  6.499260e-03  6.650011e-03
## ASV12774    -0.0012668483 -1.366266e-03 -1.470884e-03 -1.580833e-03
## ASV1321      0.0491592271  5.110648e-02  5.311595e-02  5.518856e-02
## ASV13793    -0.0142779768 -1.466617e-02 -1.505854e-02 -1.545488e-02
## ASV14482     0.0007837432  8.159496e-04  8.500810e-04  8.862539e-04
## ASV15483     0.0077717466  8.059670e-03  8.355839e-03  8.660375e-03
## ASV2062      0.0312888342  3.233083e-02  3.339893e-02  3.449346e-02
## ASV2132      0.0293785427  3.046567e-02  3.158365e-02  3.273279e-02
## ASV2413      0.0226204500  2.332874e-02  2.405324e-02  2.479422e-02
## ASV2490      0.0603390371  6.188448e-02  6.344571e-02  6.502227e-02
## ASV2594      0.0111536302  1.161745e-02  1.209988e-02  1.260160e-02
## ASV2822     -0.0376738441 -3.869839e-02 -3.973399e-02 -4.078009e-02
## ASV2863      0.0399297254  4.107252e-02  4.223494e-02  4.341696e-02
## ASV2910      0.0149255712  1.535980e-02  1.580185e-02  1.625176e-02
## ASV2980      0.0186045574  1.920823e-02  1.982550e-02  2.045644e-02
## ASV3307      0.0299839089  3.079945e-02  3.162381e-02  3.245657e-02
## ASV3474      0.0293661114  3.056555e-02  3.180543e-02  3.308649e-02
## ASV3502      0.0256931949  2.662079e-02  2.757635e-02  2.856056e-02
## ASV4236      0.0270088441  2.763677e-02  2.826718e-02  2.889979e-02
## ASV4842     -0.0033850205 -3.443792e-03 -3.498941e-03 -3.550100e-03
## ASV4894     -0.0142817214 -1.467029e-02 -1.506308e-02 -1.545991e-02
## ASV5290      0.0145335378  1.506157e-02  1.560483e-02  1.616363e-02
## ASV5501      0.0095334912  9.942681e-03  1.036974e-02  1.081545e-02
## ASV5795      0.0100289660  1.039926e-02  1.077991e-02  1.117100e-02
## ASV5987     -0.0398902307 -4.097593e-02 -4.207354e-02 -4.318252e-02
## ASV6267     -0.0449522596 -4.617592e-02 -4.741304e-02 -4.866304e-02
## ASV6862      0.0172112886  1.768563e-02  1.816780e-02  1.865786e-02
## ASV7145      0.0078507284  8.104861e-03  8.366916e-03  8.637163e-03
## ASV7673     -0.0142841587 -1.467315e-02 -1.506645e-02 -1.546388e-02
## ASV7789      0.0136014991  1.426372e-02  1.495488e-02  1.567591e-02
## ASV7809      0.0025791138  2.728272e-03  2.883782e-03  3.045736e-03
## ASV8002     -0.0180426691 -1.853433e-02 -1.903151e-02 -1.953401e-02
## ASV8205      0.0098205746  1.019060e-02  1.057203e-02  1.096503e-02
## ASV9155     -0.0039194267 -3.997686e-03 -4.074852e-03 -4.150792e-03
## ASV9221      0.0060847561  6.436777e-03  6.806376e-03  7.194188e-03
## ASV9311     -0.0289509114 -2.974077e-02 -3.053970e-02 -3.134739e-02
## ASV9557     -0.0197883445 -2.032845e-02 -2.087480e-02 -2.142719e-02
## ASV9936     -0.0399112853 -4.100110e-02 -4.210362e-02 -4.321842e-02
## ASV1445      0.0309755632  3.210303e-02  3.326216e-02  3.445333e-02
## ASV4232      0.0157220581  1.648376e-02  1.728193e-02  1.811816e-02
## ASV6479      0.0093333901  9.861991e-03  1.041719e-02  1.099998e-02
## ASV0142     -0.0170952171 -1.757831e-02 -1.806915e-02 -1.856770e-02
## ASV0378      0.0120642962  1.255562e-02  1.306194e-02  1.358329e-02
## ASV1122      0.0312270536  3.241574e-02  3.364175e-02  3.490580e-02
## ASV0123     -0.0149200064 -1.533320e-02 -1.575235e-02 -1.617738e-02
## ASV2064      0.0051738544  5.199200e-03  5.215928e-03  5.223458e-03
## ASV4459     -0.0005627179 -5.789173e-04 -5.972802e-04 -6.180934e-04
## ASV0448      0.0097962095  1.020929e-02  1.063678e-02  1.107894e-02
## ASV0397      0.0161563225  1.669521e-02  1.724679e-02  1.781114e-02
## ASV0485      0.0178449479  1.841962e-02  1.900738e-02  1.960835e-02
## ASV1566      0.0273945074  2.830282e-02  2.923236e-02  3.018325e-02
## ASV1365      0.0242545558  2.505874e-02  2.587946e-02  2.671654e-02
## ASV1065      0.0350671702  3.629198e-02  3.754860e-02  3.883731e-02
## ASV0722     -0.0025569422 -2.685902e-03 -2.821492e-03 -2.964021e-03
## ASV12660    -0.0158551517 -1.628217e-02 -1.671454e-02 -1.715216e-02
## ASV0223      0.0051691645  5.349985e-03  5.536250e-03  5.728116e-03
## ASV0229      0.0092309317  9.596715e-03  9.975416e-03  1.036743e-02
## ASV0877      0.0005468319  4.194195e-04  2.768016e-04  1.179200e-04
## ASV0983      0.0168267747  1.732479e-02  1.783085e-02  1.834481e-02
## ASV0626      0.0051809366  5.446980e-03  5.723304e-03  6.010071e-03
## ASV4146     -0.0004618255 -5.779562e-04 -7.067674e-04 -8.491934e-04
## ASV4175     -0.0254168790 -2.634413e-02 -2.729690e-02 -2.827542e-02
## ASV2082     -0.0200890301 -2.115400e-02 -2.226951e-02 -2.343724e-02
## ASV2272      0.0123404912  1.281968e-02  1.331507e-02  1.382706e-02
## ASV2245     -0.0185771316 -1.926540e-02 -1.997297e-02 -2.070001e-02
## ASV0590     -0.0205929713 -2.169961e-02 -2.285886e-02 -2.407255e-02
## ASV0217      0.0057971511  6.152714e-03  6.525178e-03  6.915027e-03
## ASV0416      0.0067500906  6.778336e-03  6.796340e-03  6.803547e-03
## ASV1056      0.0191241801  1.986531e-02  2.062851e-02  2.141398e-02
## ASV7777     -0.0250112603 -2.598468e-02 -2.699344e-02 -2.803888e-02
## ASV0455      0.0040174030  4.144011e-03  4.272521e-03  4.402818e-03
## ASV0604      0.0133216540  1.386484e-02  1.442618e-02  1.500604e-02
## ASV6100     -0.0184787874 -1.924024e-02 -2.003116e-02 -2.085265e-02
## ASV11359    -0.0353450931 -3.657437e-02 -3.783281e-02 -3.912028e-02
## ASV6604      0.0057228757  5.947904e-03  6.179295e-03  6.417003e-03
## ASV5004     -0.0126460313 -1.311599e-02 -1.360132e-02 -1.410245e-02
## ASV1483     -0.0050755491 -5.242222e-03 -5.412408e-03 -5.586062e-03
## ASV9773     -0.0170391769 -1.770263e-02 -1.838887e-02 -1.909853e-02
## ASV4059      0.0039431387  4.202953e-03  4.474566e-03  4.758071e-03
## ASV1193      0.0183560149  1.898787e-02  1.963614e-02  2.030101e-02
## ASV4610      0.0012971734  1.440131e-03  1.588634e-03  1.742495e-03
## ASV0742      0.0021395726  2.319096e-03  2.506646e-03  2.702225e-03
## ASV1502     -0.0035390915 -3.738941e-03 -3.946897e-03 -4.163035e-03
## ASV0195     -0.0011012628 -1.186340e-03 -1.275811e-03 -1.369793e-03
## ASV1213      0.0089309165  9.107796e-03  9.282766e-03  9.455576e-03
## ASV1648     -0.0166729992 -1.737034e-02 -1.809568e-02 -1.885011e-02
## ASV6984     -0.0158317940 -1.650432e-02 -1.720448e-02 -1.793335e-02
## ASV0396      0.0004970054  5.220249e-04  5.450624e-04  5.656448e-04
## ASV4297      0.0142958620  1.464715e-02  1.500132e-02  1.535830e-02
## ASV2622      0.0255712946  2.634003e-02  2.712350e-02  2.792173e-02
## ASV3512      0.0186222941  1.956252e-02  2.054735e-02  2.157856e-02
## ASV2411      0.0244534383  2.544747e-02  2.647446e-02  2.753487e-02
## ASV2291     -0.0180025285 -1.894497e-02 -1.992868e-02 -2.095474e-02
## ASV0807      0.0264912696  2.735839e-02  2.824417e-02  2.914862e-02
## ASV1292      0.0038699748  3.930143e-03  3.989859e-03  4.049272e-03
## ASV1035      0.0214183002  2.207210e-02  2.274072e-02  2.342446e-02
## ASV0070      0.0022920125  2.446707e-03  2.609819e-03  2.781652e-03
## ASV0255      0.0008560521  8.115539e-04  7.599864e-04  7.008257e-04
## ASV0057     -0.0045094560 -4.583180e-03 -4.654240e-03 -4.722400e-03
## ASV0077     -0.0003421699 -3.245833e-04 -3.059148e-04 -2.862568e-04
## ASV0625      0.0111991423  1.148330e-02  1.176980e-02  1.205850e-02
## ASV2464      0.0771983982  7.926482e-02  8.135788e-02  8.347708e-02
## ASV1315      0.0325463918  3.389153e-02  3.528270e-02  3.672071e-02
## ASV2673      0.0282018898  2.938409e-02  3.060858e-02  3.187635e-02
## ASV2161      0.0120653716  1.258977e-02  1.313497e-02  1.370160e-02
## ASV0337     -0.0059552136 -6.182289e-03 -6.416675e-03 -6.658545e-03
## ASV7680     -0.0398906075 -4.143038e-02 -4.301900e-02 -4.465731e-02
## ASV0611      0.0227241773  2.363265e-02  2.457304e-02  2.554621e-02
## ASV3118     -0.0263313081 -2.743833e-02 -2.858453e-02 -2.977074e-02
## ASV1284     -0.0061758506 -6.908922e-03 -7.694924e-03 -8.536540e-03
## ASV0889      0.0139288676  1.440407e-02  1.489361e-02  1.539802e-02
## ASV4649     -0.0079089237 -8.202206e-03 -8.504634e-03 -8.816416e-03
## ASV1108     -0.0214057099 -2.236665e-02 -2.336526e-02 -2.440252e-02
## ASV0738      0.0150730707  1.585006e-02  1.666398e-02  1.751631e-02
## ASV0473     -0.0033129680 -3.449338e-03 -3.587369e-03 -3.726636e-03
## ASV0598     -0.0090156395 -9.514511e-03 -1.003848e-02 -1.058850e-02
## ASV0429      0.0085859751  8.787849e-03  8.989236e-03  9.189863e-03
## ASV1549      0.0262172500  2.731454e-02  2.844989e-02  2.962395e-02
## ASV1203      0.0148083493  1.526417e-02  1.572817e-02  1.620023e-02
## ASV4532      0.0002402245  2.534224e-04  2.689115e-04  2.869837e-04
## ASV0274      0.0038248417  3.968738e-03  4.115076e-03  4.263621e-03
## ASV0163     -0.0099786230 -1.026380e-02 -1.055522e-02 -1.085311e-02
## ASV1298      0.0012080254  1.286301e-03  1.372073e-03  1.465999e-03
## ASV9424     -0.0325908069 -3.394080e-02 -3.534186e-02 -3.679565e-02
## ASV0412      0.0250884522  2.585672e-02  2.663989e-02  2.743796e-02
## ASV0284      0.0021326831  2.065343e-03  1.987076e-03  1.897176e-03
## ASV0620     -0.0099785651 -1.046845e-02 -1.097921e-02 -1.151146e-02
## ASV0153     -0.0344799819 -3.589422e-02 -3.735539e-02 -3.886419e-02
## ASV0498      0.0102446356  1.058288e-02  1.092634e-02  1.127466e-02
## ASV0097      0.0068907745  7.179304e-03  7.477827e-03  7.786508e-03
## ASV0104     -0.0361270239 -3.727439e-02 -3.844380e-02 -3.963501e-02
## ASV1282      0.0092789458  9.425695e-03  9.563414e-03  9.691136e-03
## ASV3883     -0.0151036780 -1.575788e-02 -1.643390e-02 -1.713189e-02
## ASV0801      0.0060294893  6.282104e-03  6.545504e-03  6.820206e-03
## ASV1611     -0.0300610343 -3.130271e-02 -3.258845e-02 -3.391927e-02
## ASV0227     -0.0085131839 -8.947335e-03 -9.400640e-03 -9.873692e-03
## ASV0833      0.0089551023  9.280168e-03  9.614221e-03  9.957369e-03
## ASV0718      0.0401559281  4.163998e-02  4.316727e-02  4.473842e-02
## ASV1139     -0.0003144132 -5.107667e-04 -7.228738e-04 -9.513796e-04
## ASV0766     -0.0075701791 -7.899824e-03 -8.240723e-03 -8.592997e-03
## ASV2091      0.0232001659  2.375945e-02  2.432007e-02  2.488151e-02
## ASV1238     -0.0345777978 -3.610564e-02 -3.769987e-02 -3.936324e-02
## ASV9193     -0.0081554041 -8.657264e-03 -9.186639e-03 -9.744665e-03
## ASV0290      0.0018111600  1.837071e-03  1.864536e-03  1.893879e-03
## ASV0231      0.0095747448  9.840469e-03  1.010820e-02  1.037761e-02
## ASV0185      0.0113761495  1.195646e-02  1.256369e-02  1.319879e-02
## ASV2330      0.0090044848  9.211637e-03  9.420440e-03  9.630954e-03
## ASV3119     -0.0099046908 -1.039733e-02 -1.091203e-02 -1.144954e-02
## ASV2368     -0.0195327500 -2.044212e-02 -2.139219e-02 -2.238456e-02
## ASV0122     -0.0064405592 -6.649143e-03 -6.862469e-03 -7.080580e-03
## ASV1044      0.0217798570  2.269281e-02  2.363992e-02  2.462218e-02
## ASV0160     -0.0054809548 -5.623728e-03 -5.769346e-03 -5.917989e-03
## ASV0326      0.0019189837  1.973854e-03  2.028653e-03  2.083227e-03
## ASV1388      0.0335797824  3.464731e-02  3.573616e-02  3.684620e-02
## ASV0792      0.0219795762  2.258020e-02  2.318760e-02  2.380148e-02
## ASV0036     -0.0101770550 -1.058010e-02 -1.099496e-02 -1.142165e-02
## ASV2125      0.0248471230  2.565961e-02  2.648881e-02  2.733455e-02
## ASV1075     -0.0006696353 -7.140018e-04 -7.615924e-04 -8.126144e-04
## ASV0390      0.0180859743  1.889814e-02  1.974449e-02  2.062624e-02
## ASV3790     -0.0218665473 -2.271643e-02 -2.359417e-02 -2.450038e-02
## ASV1535     -0.0089984073 -9.422864e-03 -9.863926e-03 -1.032192e-02
## ASV0263      0.0247677642  2.565769e-02  2.657230e-02  2.751187e-02
## ASV0675      0.0419286302  4.360240e-02  4.533231e-02  4.711953e-02
## ASV3348      0.0040879377  4.264909e-03  4.447840e-03  4.636780e-03
## ASV0058     -0.0097401378 -1.004051e-02 -1.034614e-02 -1.065691e-02
## ASV4142      0.0119493017  1.227101e-02  1.259721e-02  1.292793e-02
## ASV0059     -0.0075289892 -7.749524e-03 -7.973247e-03 -8.200068e-03
## ASV0013     -0.0154836970 -1.602715e-02 -1.658495e-02 -1.715724e-02
## ASV0033     -0.0087889897 -9.138654e-03 -9.498958e-03 -9.869972e-03
## ASV4354     -0.0098552918 -1.024339e-02 -1.064480e-02 -1.105980e-02
## ASV0022     -0.0074642607 -7.765298e-03 -8.075920e-03 -8.396229e-03
## ASV0134     -0.0085426456 -8.951525e-03 -9.379206e-03 -9.826498e-03
## ASV0415      0.0016896508  1.762591e-03  1.837587e-03  1.914630e-03
## ASV10103    -0.0398824739 -4.147996e-02 -4.313091e-02 -4.483634e-02
## ASV1613      0.0203467437  2.085568e-02  2.136486e-02  2.187354e-02
## ASV0135     -0.0020689792 -2.100417e-03 -2.130462e-03 -2.159004e-03
## ASV0469     -0.0304492666 -3.146632e-02 -3.251028e-02 -3.358166e-02
## ASV0471      0.0202079773  2.093702e-02  2.168847e-02  2.246299e-02
## ASV0451     -0.0067610995 -7.109554e-03 -7.472577e-03 -7.850470e-03
## ASV0747      0.0119193738  1.233997e-02  1.277060e-02  1.321119e-02
## ASV1314     -0.0152420603 -1.593188e-02 -1.665064e-02 -1.739934e-02
## ASV0425     -0.0325757447 -3.346440e-02 -3.436508e-02 -3.527766e-02
## ASV0559     -0.0108791704 -1.133146e-02 -1.180284e-02 -1.229413e-02
## ASV0148      0.0004207354  5.400871e-04  6.693782e-04  8.091260e-04
## ASV0129      0.0075808543  8.046723e-03  8.537556e-03  9.054326e-03
## ASV1072      0.0008710205  8.301362e-04  7.838023e-04  7.317522e-04
## ASV2390      0.0135812623  1.378859e-02  1.398577e-02  1.417199e-02
## ASV0548      0.0133339531  1.377759e-02  1.423120e-02  1.469480e-02
## ASV0168     -0.0063391586 -6.539354e-03 -6.743954e-03 -6.953000e-03
## ASV0066     -0.0071205424 -7.328257e-03 -7.538152e-03 -7.750000e-03
## ASV0468     -0.0045782632 -4.758273e-03 -4.944862e-03 -5.138266e-03
## ASV0172     -0.0007949782 -7.628661e-04 -7.261791e-04 -6.846609e-04
## ASV0236      0.0055790985  5.982041e-03  6.406984e-03  6.854638e-03
## ASV0250      0.0174697819  1.832870e-02  1.922687e-02  2.016576e-02
## ASV0338      0.0059871162  6.193848e-03  6.404119e-03  6.617724e-03
## ASV0450     -0.0024213459 -2.560390e-03 -2.706551e-03 -2.860094e-03
## ASV0377      0.0088726010  9.132623e-03  9.395490e-03  9.660916e-03
## ASV1022      0.0002176717  2.642028e-04  3.155382e-04  3.720385e-04
## ASV6174     -0.0010548255 -1.116712e-03 -1.180372e-03 -1.245596e-03
## ASV0786     -0.0034636827 -3.637523e-03 -3.817240e-03 -4.002774e-03
## ASV0053     -0.0110985962 -1.149293e-02 -1.189765e-02 -1.231285e-02
## ASV0697     -0.0056343115 -5.811734e-03 -5.993853e-03 -6.180862e-03
## ASV0785      0.0125806898  1.297970e-02  1.338737e-02  1.380383e-02
## ASV1967     -0.0124397327 -1.284324e-02 -1.325603e-02 -1.367812e-02
## ASV0385      0.0055994755  5.807887e-03  6.020616e-03  6.237452e-03
## ASV0295      0.0028660376  3.044553e-03  3.232727e-03  3.430946e-03
## ASV0072     -0.0086588000 -8.875795e-03 -9.092643e-03 -9.308982e-03
## ASV0157      0.0018233152  2.016188e-03  2.222871e-03  2.444059e-03
## ASV0501      0.0241449415  2.498667e-02  2.584753e-02  2.672732e-02
## ASV10729    -0.0323071978 -3.354494e-02 -3.482141e-02 -3.613728e-02
## ASV1470      0.0095486289  9.687630e-03  9.818230e-03  9.939633e-03
## ASV0050     -0.0231257353 -2.384608e-02 -2.457944e-02 -2.532560e-02
## ASV0411     -0.0070284738 -7.330421e-03 -7.644600e-03 -7.971493e-03
## ASV0549      0.0104217355  1.082617e-02  1.124311e-02  1.167274e-02
## ASV0184      0.0031886464  3.317433e-03  3.451666e-03  3.591615e-03
## ASV0705      0.0047983301  4.910094e-03  5.020605e-03  5.129541e-03
## ASV1715      0.0131286252  1.359336e-02  1.407027e-02  1.455944e-02
## ASV0603      0.0028936466  3.047104e-03  3.209266e-03  3.380610e-03
## ASV0826      0.0209302335  2.164501e-02  2.237843e-02  2.313077e-02
## ASV0034     -0.0058304132 -5.992280e-03 -6.155835e-03 -6.320970e-03
## ASV0838     -0.0031935230 -3.660058e-03 -4.165613e-03 -4.712575e-03
## ASV0614     -0.0056850404 -5.876786e-03 -6.073310e-03 -6.274675e-03
## ASV0014     -0.0152889377 -1.580288e-02 -1.632871e-02 -1.686644e-02
## ASV0585     -0.0029872525 -3.239716e-03 -3.505186e-03 -3.783839e-03
## ASV0016     -0.0159974416 -1.653641e-02 -1.708796e-02 -1.765212e-02
## ASV5394     -0.0128693169 -1.332627e-02 -1.379412e-02 -1.427272e-02
## ASV0666      0.0219024260  2.250466e-02  2.311430e-02  2.373112e-02
## ASV2085     -0.0017511994 -2.084626e-03 -2.442466e-03 -2.825805e-03
## ASV0003     -0.0108830600 -1.124968e-02 -1.162495e-02 -1.200890e-02
## ASV0346      0.0067573823  7.015873e-03  7.281045e-03  7.552834e-03
## ASV0267      0.0013512366  1.427698e-03  1.505600e-03  1.584652e-03
## ASV0353      0.0106286024  1.105884e-02  1.150361e-02  1.196322e-02
## ASV2419      0.0223505895  2.306029e-02  2.378306e-02  2.451856e-02
## ASV0447      0.0156073227  1.623579e-02  1.688549e-02  1.755691e-02
## ASV0654      0.0189347491  1.956408e-02  2.020705e-02  2.086360e-02
## ASV0151      0.0046589229  4.895912e-03  5.143145e-03  5.400870e-03
## ASV0065     -0.0069673233 -7.190058e-03 -7.417429e-03 -7.649436e-03
## ASV0527      0.0178319038  1.842686e-02  1.903525e-02  1.965701e-02
## ASV4055     -0.0050654807 -5.355928e-03 -5.663980e-03 -5.990702e-03
## ASV0166     -0.0075642440 -7.770692e-03 -7.979690e-03 -8.191203e-03
## ASV0417     -0.0021305619 -2.148340e-03 -2.163614e-03 -2.176266e-03
## ASV0078     -0.0044325026 -4.538396e-03 -4.643340e-03 -4.747052e-03
## ASV0322      0.0015489061  1.725363e-03  1.915341e-03  2.119528e-03
## ASV0156     -0.0147543455 -1.534298e-02 -1.595249e-02 -1.658350e-02
## ASV0648     -0.0322768027 -3.353932e-02 -3.484195e-02 -3.618528e-02
## ASV0407     -0.0029263222 -3.063854e-03 -3.207590e-03 -3.357774e-03
## ASV2030     -0.0055102179 -5.775790e-03 -6.055237e-03 -6.349216e-03
## ASV0300      0.0042390339  4.412018e-03  4.590491e-03  4.774499e-03
## ASV1150      0.0012928771  1.349636e-03  1.407847e-03  1.467441e-03
## ASV0958      0.0140434784  1.467963e-02  1.534230e-02  1.603239e-02
## ASV0216     -0.0114392587 -1.187443e-02 -1.232627e-02 -1.279551e-02
## ASV0446      0.0195190005  2.025705e-02  2.101645e-02  2.179737e-02
## ASV0367     -0.0122118367 -1.266438e-02 -1.313014e-02 -1.360931e-02
## ASV0200     -0.0070363102 -7.281039e-03 -7.531225e-03 -7.786769e-03
## ASV0334     -0.0015739591 -1.582859e-03 -1.591625e-03 -1.600458e-03
## ASV1311      0.0020727990  2.054515e-03  2.030128e-03  1.999265e-03
## ASV0458      0.0030474351  3.038799e-03  3.023901e-03  3.002424e-03
## ASV1371      0.0014102628  1.459131e-03  1.508281e-03  1.557578e-03
## ASV0418      0.0122153182  1.254794e-02  1.288459e-02  1.322515e-02
## ASV0004      0.0016734781  1.714982e-03  1.756721e-03  1.798667e-03
## ASV1943      0.0206165689  2.077950e-02  2.092436e-02  2.105054e-02
## ASV1495     -0.0080802813 -8.554939e-03 -9.054035e-03 -9.578462e-03
## ASV0901     -0.0156550934 -1.632447e-02 -1.702052e-02 -1.774416e-02
## ASV0628      0.0041120873  4.151407e-03  4.185093e-03  4.212686e-03
## ASV0400      0.0031307752  3.188022e-03  3.242356e-03  3.293370e-03
## ASV0116     -0.0044878271 -4.673065e-03 -4.865083e-03 -5.064074e-03
## ASV0788      0.0404300974  4.213569e-02  4.390715e-02  4.574668e-02
## ASV0117      0.0033560775  3.503848e-03  3.657176e-03  3.816198e-03
## ASV3137     -0.0006123475 -6.239493e-04 -6.348270e-04 -6.448548e-04
## ASV0001      0.0017191006  1.758517e-03  1.798029e-03  1.837623e-03
## ASV1651      0.0053303659  5.474570e-03  5.620936e-03  5.769508e-03
## ASV1692      0.0328808574  3.422572e-02  3.561913e-02  3.706251e-02
## ASV0660      0.0050481318  5.032421e-03  5.004152e-03  4.962548e-03
## ASV0508      0.0002159598  2.117457e-04  2.063999e-04  1.998053e-04
## ASV1660     -0.0081168182 -8.469636e-03 -8.834074e-03 -9.210185e-03
## ASV0233      0.0090612486  9.394936e-03  9.738500e-03  1.009212e-02
## ASV1343     -0.0185701936 -1.933180e-02 -2.012141e-02 -2.093987e-02
## ASV0209      0.0057569760  5.881711e-03  6.005132e-03  6.126964e-03
## ASV0193     -0.0069266027 -7.077136e-03 -7.225599e-03 -7.371603e-03
## ASV0357      0.0068054157  7.184187e-03  7.583010e-03  8.002770e-03
## ASV0198      0.0065792657  6.804103e-03  7.035437e-03  7.273447e-03
## ASV0007      0.0013421287  1.365170e-03  1.387721e-03  1.409759e-03
## ASV1772     -0.0001656995 -1.645259e-06  1.827332e-04  3.891660e-04
## ASV0009      0.0009591810  9.687332e-04  9.774944e-04  9.854497e-04
## ASV0006     -0.0025043358 -2.612765e-03 -2.725122e-03 -2.841483e-03
## ASV0011     -0.0073493781 -7.635587e-03 -7.931109e-03 -8.236144e-03
## ASV0015      0.0006762232  6.781702e-04  6.789510e-04  6.784950e-04
## ASV0017      0.0008168936  8.243092e-04  8.308309e-04  8.364049e-04
## ASV0235     -0.0069750246 -7.254606e-03 -7.544088e-03 -7.843770e-03
## ASV0382      0.0046760257  4.801723e-03  4.925598e-03  5.047083e-03
## ASV2357      0.0222945170  2.317918e-02  2.409408e-02  2.503990e-02
## ASV0567     -0.0049421187 -5.175176e-03 -5.419459e-03 -5.675490e-03
## ASV0165      0.0035610578  3.691409e-03  3.825276e-03  3.962684e-03
## ASV0005      0.0045701999  4.717887e-03  4.868420e-03  5.021749e-03
## ASV0384      0.0011192586  1.226913e-03  1.342276e-03  1.465770e-03
## ASV0002      0.0007670464  7.913672e-04  8.162848e-04  8.418074e-04
## ASV3017      0.0196153972  2.010168e-02  2.058961e-02  2.107872e-02
## ASV0091     -0.0007445700 -7.831966e-04 -8.243515e-04 -8.682213e-04
## ASV0186     -0.0094251413 -9.730973e-03 -1.004218e-02 -1.035858e-02
## ASV0370      0.0046169303  4.764233e-03  4.915171e-03  5.069854e-03
## ASV0018      0.0060005718  6.201130e-03  6.406092e-03  6.615435e-03
## ASV1377      0.0508376630  5.224653e-02  5.367211e-02  5.511376e-02
## ASV0019      0.0063567228  6.572125e-03  6.792506e-03  7.017864e-03
## ASV0023     -0.0045930159 -4.769366e-03 -4.950805e-03 -5.137356e-03
## ASV2194      0.0083351378  8.705779e-03  9.091609e-03  9.493126e-03
## ASV1155      0.0225508662  2.328910e-02  2.404740e-02  2.482633e-02
## ASV0510     -0.0042855883 -4.373082e-03 -4.461816e-03 -4.551957e-03
## ASV2371     -0.0131662928 -1.355825e-02 -1.395665e-02 -1.436132e-02
## ASV0024     -0.0056566882 -5.872935e-03 -6.095471e-03 -6.324342e-03
## ASV2452      0.0097976214  9.939727e-03  1.007476e-02  1.020224e-02
## ASV2332     -0.0406493983 -4.200417e-02 -4.339409e-02 -4.481972e-02
## ASV2591      0.0167473668  1.742690e-02  1.812465e-02  1.884048e-02
## ASV0521      0.0116871008  1.215313e-02  1.263502e-02  1.313312e-02
## ASV5542      0.0107329005  1.113512e-02  1.154951e-02  1.197629e-02
## ASV0336     -0.0028726635 -3.030049e-03 -3.195153e-03 -3.368311e-03
## ASV10102     0.0198848544  2.062494e-02  2.138544e-02  2.216646e-02
## ASV16823    -0.0208866677 -2.143692e-02 -2.199426e-02 -2.255857e-02
## ASV3104      0.1080690581  1.109157e-01  1.137990e-01  1.167184e-01
## ASV0781      0.0200600526  2.078020e-02  2.152227e-02  2.228684e-02
## ASV10899     0.0197383086  2.071256e-02  2.172962e-02  2.279091e-02
## ASV11222    -0.0367611015 -3.772929e-02 -3.870991e-02 -3.970279e-02
## ASV11327    -0.0330040650 -3.387321e-02 -3.475350e-02 -3.564477e-02
## ASV12458    -0.0367591061 -3.772703e-02 -3.870736e-02 -3.969991e-02
## ASV1636      0.0240291425  2.476026e-02  2.550581e-02  2.626585e-02
## ASV1890     -0.0138077908 -1.409036e-02 -1.437483e-02 -1.466139e-02
## ASV2898      0.0324356720  3.343043e-02  3.444544e-02  3.548088e-02
## ASV8328      0.0167151675  1.772554e-02  1.878690e-02  1.990098e-02
## ASV0709     -0.0383646904 -3.958844e-02 -4.083721e-02 -4.211091e-02
## ASV0856      0.0416254814  4.331239e-02  4.505464e-02  4.685310e-02
## ASV0909      0.0198892761  2.092430e-02  2.200490e-02  2.313237e-02
## ASV0937     -0.0287692872 -2.999651e-02 -3.127292e-02 -3.260022e-02
## ASV11390    -0.0524599012 -5.384085e-02 -5.523946e-02 -5.665546e-02
## ASV11966     0.0218879381  2.279575e-02  2.373297e-02  2.469991e-02
## ASV12990     0.0099514473  1.023343e-02  1.052050e-02  1.081273e-02
## ASV14797     0.0142493250  1.464218e-02  1.504151e-02  1.544738e-02
## ASV14904    -0.0752761513 -7.725743e-02 -7.926401e-02 -8.129553e-02
## ASV15304     0.0156511278  1.634044e-02  1.705345e-02  1.779044e-02
## ASV16696    -0.0260087235 -2.669322e-02 -2.738646e-02 -2.808832e-02
## ASV1690      0.0681446353  7.070979e-02  7.334152e-02  7.603958e-02
## ASV2029      0.0381346879  3.940733e-02  4.071154e-02  4.204767e-02
## ASV2834      0.0541890603  5.615386e-02  5.817024e-02  6.023838e-02
## ASV4003      0.0597620607  6.262025e-02  6.561010e-02  6.873714e-02
## ASV4064      0.0266496619  2.765743e-02  2.869585e-02  2.976551e-02
## ASV4294      0.0231732960  2.430062e-02  2.547731e-02  2.670502e-02
## ASV4609      0.0130380372  1.349942e-02  1.397559e-02  1.446700e-02
## ASV6283     -0.0243117805 -2.495155e-02 -2.559948e-02 -2.625546e-02
## ASV6491     -0.0348458157 -3.576275e-02 -3.669139e-02 -3.763157e-02
## ASV7453      0.0298731584  3.113846e-02  3.244635e-02  3.379740e-02
## ASV7959      0.0154460636  1.624479e-02  1.708013e-02  1.795339e-02
## ASV8219      0.3011382544  3.090622e-01  3.170872e-01  3.252120e-01
## ASV8547     -0.0311968541 -3.201773e-02 -3.284910e-02 -3.369079e-02
## ASV9319      0.0220626477  2.299890e-02  2.397137e-02  2.498124e-02
## ASV9382     -0.0610404175 -6.264656e-02 -6.427322e-02 -6.592011e-02
## ASV11516    -0.0407698978 -4.184268e-02 -4.292916e-02 -4.402917e-02
## ASV14377    -0.0294379706 -3.021258e-02 -3.099710e-02 -3.179139e-02
## ASV1867      0.0340087963  3.534277e-02  3.672160e-02  3.814644e-02
## ASV1895      0.0089153295  8.987529e-03  9.047459e-03  9.094326e-03
## ASV3168      0.0141782823  1.450403e-02  1.482964e-02  1.515481e-02
## ASV4449      0.1072994001  1.112711e-01  1.153690e-01  1.195964e-01
## ASV6596      0.0324769596  3.402177e-02  3.563316e-02  3.731329e-02
## ASV7492      0.0043042663  4.712814e-03  5.145007e-03  5.601567e-03
## ASV9854     -0.0059866814 -6.136081e-03 -6.286796e-03 -6.438756e-03
## ASV6296      0.4939884277  5.069877e-01  5.201534e-01  5.334833e-01
## ASV4201      0.0129910641  1.380529e-02  1.466364e-02  1.556797e-02
## ASV0552      0.0226657047  2.350233e-02  2.436162e-02  2.524363e-02
## ASV3671     -0.0148190352 -1.544768e-02 -1.610471e-02 -1.679152e-02
## ASV3529      0.0019138561  2.109021e-03  2.312531e-03  2.524314e-03
## ASV1060      0.0075798817  7.940770e-03  8.318622e-03  8.714180e-03
## ASV0239     -0.0049592780 -5.054568e-03 -5.148494e-03 -5.240872e-03
## ASV5711     -0.0313345849 -3.237348e-02 -3.343775e-02 -3.452758e-02
## ASV4152     -0.0500491321 -5.185618e-02 -5.371135e-02 -5.561483e-02
## ASV1461      0.0166044263  1.694699e-02  1.728737e-02  1.762520e-02
## ASV2877      0.0089525436  9.135214e-03  9.314990e-03  9.491418e-03
## ASV0012      0.0022325704  2.314158e-03  2.398163e-03  2.484626e-03
## ASV9823     -0.0007395950 -9.246174e-04 -1.125113e-03 -1.341862e-03
## ASV0008      0.0023232929  2.406964e-03  2.493095e-03  2.581730e-03
## ASV7832     -0.0312611238 -3.247676e-02 -3.373152e-02 -3.502610e-02
## ASV1915     -0.0037378994 -3.901057e-03 -4.071787e-03 -4.250406e-03
## ASV0055     -0.0040103214 -4.206542e-03 -4.411395e-03 -4.625174e-03
## ASV0032      0.0004078321  4.023378e-04  3.962680e-04  3.896853e-04
## ASV2977     -0.0405440540 -4.196571e-02 -4.342222e-02 -4.491349e-02
## ASV0466      0.0219261908  2.235496e-02  2.277712e-02  2.319189e-02
## ASV3866      0.0260587769  2.714631e-02  2.827522e-02  2.944684e-02
## ASV0040      0.0084963756  8.813950e-03  9.140950e-03  9.477509e-03
## ASV0496     -0.0063990070 -6.771806e-03 -7.161777e-03 -7.569313e-03
## ASV0052      0.0071988327  7.472784e-03  7.755577e-03  8.047437e-03
## ASV3828     -0.0172333397 -1.767415e-02 -1.811967e-02 -1.856978e-02
## ASV1930      0.0092827904  9.507368e-03  9.732186e-03  9.957033e-03
## ASV2126      0.0192202654  1.987547e-02  2.054850e-02  2.123970e-02
## ASV0793      0.0282202359  2.932824e-02  3.047292e-02  3.165514e-02
## ASV0299     -0.0015494032 -1.676342e-03 -1.813478e-03 -1.961494e-03
## ASV0208      0.0195368862  2.029730e-02  2.108389e-02  2.189742e-02
## ASV0511     -0.0047285808 -4.824856e-03 -4.921976e-03 -5.020079e-03
## ASV1123     -0.0155394527 -1.586972e-02 -1.619697e-02 -1.652047e-02
## ASV0099      0.0015249173  1.617509e-03  1.715330e-03  1.818607e-03
## ASV0752     -0.0161973652 -1.689154e-02 -1.761216e-02 -1.836003e-02
## ASV0883      0.0213209644  2.217767e-02  2.306112e-02  2.397153e-02
## ASV0683      0.0271306612  2.823109e-02  2.936926e-02  3.054598e-02
## ASV4117     -0.0401918891 -4.177460e-02 -4.341171e-02 -4.510461e-02
## ASV2172      0.0001876186  1.070587e-04  1.848104e-05 -7.859012e-05
## ASV0330     -0.0077586507 -8.072563e-03 -8.398026e-03 -8.735419e-03
## ASV0728      0.0332988645  3.444812e-02  3.562745e-02  3.683731e-02
## ASV0499      0.0108888217  1.134364e-02  1.181490e-02  1.230301e-02
## ASV0120     -0.0147323092 -1.522327e-02 -1.572438e-02 -1.623549e-02
## ASV1446      0.0037494739  3.603389e-03  3.436178e-03  3.246577e-03
## ASV17171    -0.0303644401 -3.153406e-02 -3.274396e-02 -3.399529e-02
## ASV0533      0.0031154609  3.257205e-03  3.404373e-03  3.557078e-03
## ASV2495     -0.0124624139 -1.309605e-02 -1.375704e-02 -1.444604e-02
## ASV5582      0.0066685956  6.681253e-03  6.681862e-03  6.669588e-03
## ASV1488      0.0036555609  3.713241e-03  3.766979e-03  3.816338e-03
## ASV0682      0.0080288536  8.360848e-03  8.704109e-03  9.058825e-03
## ASV0068     -0.0113907056 -1.177261e-02 -1.216197e-02 -1.255856e-02
## ASV1987     -0.0360438835 -3.757735e-02 -3.916635e-02 -4.081218e-02
## ASV0035     -0.0058771194 -6.250817e-03 -6.646693e-03 -7.065841e-03
## ASV7192     -0.0157187708 -1.619931e-02 -1.668745e-02 -1.718288e-02
## ASV0873     -0.0442315767 -4.693543e-02 -4.975658e-02 -5.269701e-02
## ASV4749     -0.0098636554 -1.053531e-02 -1.124289e-02 -1.198762e-02
## ASV2174      0.0064719162  6.499168e-03  6.516103e-03  6.522126e-03
## ASV1476     -0.0160465919 -1.675055e-02 -1.748185e-02 -1.824123e-02
## ASV0740     -0.0438566806 -4.572949e-02 -4.767468e-02 -4.969455e-02
## ASV0170     -0.0073593317 -7.636282e-03 -7.922084e-03 -8.216958e-03
## ASV2466     -0.0343489230 -3.567874e-02 -3.705274e-02 -3.847196e-02
## ASV1709      0.0119656365  1.249677e-02  1.305618e-02  1.364567e-02
## ASV6170     -0.0576105652 -5.993025e-02 -6.232925e-02 -6.480926e-02
## ASV3673      0.0297254818  3.096110e-02  3.224030e-02  3.356402e-02
## ASV1745     -0.0091250928 -9.545704e-03 -9.983130e-03 -1.043781e-02
##                                                                    
## (Intercept)  1.950955e-01  0.2015597410  0.2081650271  0.2149107921
## ASV1236      3.196585e-02  0.0328849621  0.0338199336  0.0347707003
## ASV0421      8.997843e-03  0.0094151946  0.0098459274  0.0102900360
## ASV0691     -1.545344e-02 -0.0156445603 -0.0158298043 -0.0160090441
## ASV0899      2.667693e-02  0.0273687708  0.0280678190  0.0287739366
## ASV1004      6.360299e-02  0.0653775228  0.0671788241  0.0690066156
## ASV1041     -2.286916e-02 -0.0233150353 -0.0237523260 -0.0241800474
## ASV1058      4.001640e-02  0.0411670416  0.0423382178  0.0435299412
## ASV12542     1.386518e-02  0.0142364786  0.0146152732  0.0150018044
## ASV1294      3.775168e-02  0.0388675407  0.0400063417  0.0411684063
## ASV13113     2.103227e-02  0.0219791485  0.0229645478  0.0239896689
## ASV1318      3.689647e-02  0.0379422231  0.0390060042  0.0400879175
## ASV2269     -6.067931e-02 -0.0622059728 -0.0637423463 -0.0652874716
## ASV2542      4.386826e-02  0.0456036165  0.0473978932  0.0492524678
## ASV2660     -2.384735e-02 -0.0244603008 -0.0250797910 -0.0257056763
## ASV2737      6.922694e-03  0.0070889581  0.0072585186  0.0074315108
## ASV2840      2.623112e-02  0.0267006101  0.0271634791  0.0276192201
## ASV3053      1.576650e-01  0.1617824283  0.1659618830  0.1702035790
## ASV3077      1.059789e-02  0.0109036835  0.0112162913  0.0115358512
## ASV3134      3.116383e-02  0.0325098788  0.0339082490  0.0353604778
## ASV3140      3.256777e-02  0.0336614879  0.0347802102  0.0359239448
## ASV3579      1.756792e-02  0.0183540802  0.0191684004  0.0200112513
## ASV6119     -1.659574e-02 -0.0170133481 -0.0174338299 -0.0178569740
## ASV7557     -3.372386e-02 -0.0345727686 -0.0354276479 -0.0362880754
## ASV8422      8.336529e-03  0.0085782415  0.0088258886  0.0090796535
## ASV1086     -9.745688e-04 -0.0010060242 -0.0010392289 -0.0010742702
## ASV1310      1.657747e-02  0.0170185714  0.0174644430  0.0179148527
## ASV15750    -1.215459e-03 -0.0012048125 -0.0011911861 -0.0011744587
## ASV16905    -6.934773e-03 -0.0071096928 -0.0072859279 -0.0074633995
## ASV2033      4.434621e-02  0.0460378325  0.0477800862  0.0495737695
## ASV2089      1.466074e-02  0.0150300925  0.0154021134  0.0157766302
## ASV2127      4.980770e-02  0.0512139676  0.0526438416  0.0540973088
## ASV2725      3.604664e-02  0.0369334320  0.0378279233  0.0387298089
## ASV2804     -1.435755e-02 -0.0147202370 -0.0150857455 -0.0154539159
## ASV3075      4.221339e-02  0.0438280370  0.0454991772  0.0472284520
## ASV3327      6.136429e-02  0.0636266748  0.0659542844  0.0683480841
## ASV3342      5.193490e-02  0.0538652489  0.0558546833  0.0579044033
## ASV3532     -5.525296e-02 -0.0573180710 -0.0594533559 -0.0616611600
## ASV3600      2.569566e-02  0.0266181980  0.0275664728  0.0285407937
## ASV4013      4.112618e-02  0.0423726540  0.0436410940  0.0449311559
## ASV4136      3.829507e-02  0.0393515569  0.0404259618  0.0415183636
## ASV4195      1.466008e-01  0.1503109561  0.1540509877  0.1578191571
## ASV4407     -5.664807e-02 -0.0580824285 -0.0595283865 -0.0609852781
## ASV4717      7.518641e-03  0.0076865256  0.0078580175  0.0080333628
## ASV6794      2.209200e-02  0.0226940383  0.0233084588  0.0239355518
## ASV8324     -2.907280e-02 -0.0298098445 -0.0305529423 -0.0313017400
## ASV8981      2.192574e-03  0.0023693943  0.0025559288  0.0027524527
## ASV9859      2.293746e-02  0.0241215257  0.0253628042  0.0266635917
## ASV0936      3.757027e-02  0.0388491592  0.0401570184  0.0414937711
## ASV12683    -3.947851e-04 -0.0003966124 -0.0003965836 -0.0003945089
## ASV1293      1.899226e-02  0.0194945974  0.0200031207  0.0205177210
## ASV13055     1.571749e-03  0.0016948459  0.0018246448  0.0019613656
## ASV17063    -1.509288e-02 -0.0154760481 -0.0158623577 -0.0162515992
## ASV2228      1.230995e-02  0.0126225497  0.0129377111  0.0132552610
## ASV2769      4.359012e-03  0.0045421415  0.0047296637  0.0049214397
## ASV2803      1.121166e-02  0.0114607272  0.0117120341  0.0119656427
## ASV2896      1.680823e-02  0.0175393695  0.0183013368  0.0190953529
## ASV3062      2.294395e-02  0.0239159700  0.0249203247  0.0259574215
## ASV3107      2.826708e-02  0.0293523369  0.0304725619  0.0316284562
## ASV3265      2.664888e-02  0.0273352204  0.0280288831  0.0287296356
## ASV3666     -3.280266e-04 -0.0003615549 -0.0003970789 -0.0004346379
## ASV4497      1.001499e-02  0.0103070548  0.0106043655  0.0109069302
## ASV6914     -3.218266e-03 -0.0033651971 -0.0035172733 -0.0036745524
## ASV0576     -2.548700e-02 -0.0259696685 -0.0264498818 -0.0269273237
## ASV0673      4.032102e-02  0.0415499274  0.0428044221  0.0440847750
## ASV0772      2.037369e-02  0.0210724936  0.0217911067  0.0225299822
## ASV0862      8.248722e-03  0.0086646546  0.0090936659  0.0095356021
## ASV0898      1.950768e-02  0.0202414252  0.0209957727  0.0217709451
## ASV0910      2.153966e-02  0.0223665548  0.0232197364  0.0240997200
## ASV0964     -1.027042e-02 -0.0104842117 -0.0106982968 -0.0109126485
## ASV10059     1.795703e-02  0.0187130102  0.0194953886  0.0203046849
## ASV10263    -2.299040e-02 -0.0235755906 -0.0241655878 -0.0247600332
## ASV1088      3.815707e-02  0.0396735393  0.0412444327  0.0428713389
## ASV1101      3.256616e-02  0.0334034749  0.0342496142  0.0351043482
## ASV1183      1.135752e-02  0.0117654646  0.0121858730  0.0126190587
## ASV11956     6.803209e-03  0.0069590052  0.0071175628  0.0072790600
## ASV12774    -1.696237e-03 -0.0018172102 -0.0019438578 -0.0020762759
## ASV1321      5.732516e-02  0.0595265570  0.0617935053  0.0641266917
## ASV13793    -1.585499e-02 -0.0162586252 -0.0166655636 -0.0170755559
## ASV14482     9.245898e-04  0.0009652156  0.0010082635  0.0010538703
## ASV15483     8.973398e-03  0.0092950335  0.0096254089  0.0099646548
## ASV2062      3.561476e-02  0.0367631539  0.0379389471  0.0391424438
## ASV2132      3.391338e-02  0.0351256723  0.0363698824  0.0376462082
## ASV2413      2.555195e-02  0.0263267081  0.0271188023  0.0279285415
## ASV2490      6.661369e-02  0.0682195311  0.0698393620  0.0714727606
## ASV2594      1.312334e-02  0.0136658191  0.0142297880  0.0148160137
## ASV2822     -4.183614e-02 -0.0429015486 -0.0439757131 -0.0450580125
## ASV2863      4.461857e-02  0.0458397418  0.0470804423  0.0483406403
## ASV2910      1.670958e-02  0.0171753651  0.0176491891  0.0181311263
## ASV2980      2.110111e-02  0.0217595920  0.0224319261  0.0231181663
## ASV3307      3.329728e-02  0.0341455116  0.0350007957  0.0358626752
## ASV3474      3.440945e-02  0.0357749863  0.0371837687  0.0386364237
## ASV3502      2.957413e-02  0.0306177687  0.0316922171  0.0327982292
## ASV4236      2.953431e-02  0.0301704983  0.0308081012  0.0314468897
## ASV4842     -3.596892e-03 -0.0036389320 -0.0036758322 -0.0037072026
## ASV4894     -1.586056e-02 -0.0162648460 -0.0166725481 -0.0170834666
## ASV5290      1.673829e-02  0.0173291309  0.0179365068  0.0185607695
## ASV5501      1.128059e-02  0.0117659897  0.0122724871  0.0128009417
## ASV5795      1.157260e-02  0.0119847726  0.0124075741  0.0128410422
## ASV5987     -4.430234e-02 -0.0454324706 -0.0465723668 -0.0477215074
## ASV6267     -4.992534e-02 -0.0511993420 -0.0524844634 -0.0537801379
## ASV6862      1.915586e-02  0.0196618615  0.0201759139  0.0206980846
## ASV7145      8.915881e-03  0.0092033483  0.0094998422  0.0098056396
## ASV7673     -1.586527e-02 -0.0162704312 -0.0166791944 -0.0170913877
## ASV7789      1.642776e-02  0.0172113638  0.0180276817  0.0188776652
## ASV7809      3.214219e-03  0.0033893007  0.0035710430  0.0037594927
## ASV8002     -2.004161e-02 -0.0205541031 -0.0210712908 -0.0215929810
## ASV8205      1.136977e-02  0.0117864278  0.0122151418  0.0126560496
## ASV9155     -4.225376e-03 -0.0042984748 -0.0043699644 -0.0044397241
## ASV9221      7.600860e-03  0.0080270459  0.0084734123  0.0089406333
## ASV9311     -3.216354e-02 -0.0329878546 -0.0338200559 -0.0346598784
## ASV9557     -2.198542e-02 -0.0225492953 -0.0231186369 -0.0236932682
## ASV9936     -4.434513e-02 -0.0454833615 -0.0466327604 -0.0477929896
## ASV1445      3.567685e-02  0.0369330512  0.0382221952  0.0395445316
## ASV4232      1.899413e-02  0.0199115361  0.0208721343  0.0218777290
## ASV6479      1.161136e-02  0.0122523509  0.0129239614  0.0136272174
## ASV0142     -1.907394e-02 -0.0195878474 -0.0201094098 -0.0206386095
## ASV0378      1.411971e-02  0.0146711740  0.0152376573  0.0158190856
## ASV1122      3.620862e-02  0.0375509316  0.0389334362  0.0403568272
## ASV0123     -1.660822e-02 -0.0170447952 -0.0174870308 -0.0179348555
## ASV2064      5.221200e-03  0.0052085542  0.0051849100  0.0051496501
## ASV4459     -6.416624e-04 -0.0006683115 -0.0006983837 -0.0007322402
## ASV0448      1.153603e-02  0.0120082892  0.0124959413  0.0129991974
## ASV0397      1.838835e-02  0.0189784842  0.0195816248  0.0201978414
## ASV0485      2.022262e-02  0.0208502919  0.0214914557  0.0221461990
## ASV1566      3.115558e-02  0.0321494327  0.0331648905  0.0342020047
## ASV1365      2.756978e-02  0.0284389633  0.0293238701  0.0302242649
## ASV1065      4.015836e-02  0.0415119882  0.0428984085  0.0443178084
## ASV0722     -3.113807e-03 -0.0032711792 -0.0034364722 -0.0036100303
## ASV12660    -1.759494e-02 -0.0180427690 -0.0184955609 -0.0189532281
## ASV0223      5.925741e-03  0.0061292882  0.0063389235  0.0065548157
## ASV0229      1.077316e-02  0.0111930201  0.0116274455  0.0120768718
## ASV0877     -5.832475e-05 -0.0002530732 -0.0004675058 -0.0007028425
## ASV0983      1.886651e-02  0.0193957662  0.0199324121  0.0204762557
## ASV0626      6.307435e-03  0.0066155424  0.0069345333  0.0072645414
## ASV4146     -1.006202e-03 -0.0011787899 -0.0013679839 -0.0015748340
## ASV4175     -2.927984e-02 -0.0303103499 -0.0313670599 -0.0324500748
## ASV2082     -2.465891e-02 -0.0259362127 -0.0272708349 -0.0286644497
## ASV2272      1.435607e-02  0.0149025205  0.0154668179  0.0160493872
## ASV2245     -2.144665e-02 -0.0222130024 -0.0229991576 -0.0238051836
## ASV0590     -2.534251e-02 -0.0266705773 -0.0280585984 -0.0295084254
## ASV0217      7.322746e-03  0.0077488236  0.0081937500  0.0086580189
## ASV0416      6.799400e-03  0.0067833432  0.0067548255  0.0067132992
## ASV1056      2.222191e-02  0.0230524552  0.0239057438  0.0247818827
## ASV7777     -2.912241e-02 -0.0302455251 -0.0314097716 -0.0326167843
## ASV0455      4.534779e-03  0.0046682683  0.0048031375  0.0049392277
## ASV0604      1.560473e-02  0.0162225824  0.0168599163  0.0175170350
## ASV6100     -2.170583e-02 -0.0225918663 -0.0235119605 -0.0244673551
## ASV11359    -4.043662e-02 -0.0417816199 -0.0431550002 -0.0445564480
## ASV6604      6.660956e-03  0.0069110596  0.0071671918  0.0074292031
## ASV5004     -1.461984e-02 -0.0151539603 -0.0157052769 -0.0162742649
## ASV1483     -5.763123e-03 -0.0059435218 -0.0061271732 -0.0063139793
## ASV9773     -1.983230e-02 -0.0205908536 -0.0213748821 -0.0221850929
## ASV4059      5.053520e-03  0.0053609240  0.0056802461  0.0060114016
## ASV1193      2.098266e-02  0.0216812439  0.0223969263  0.0231298461
## ASV4610      1.901493e-03  0.0020653760  0.0022338583  0.0024066245
## ASV0742      2.905813e-03  0.0031173680  0.0033368235  0.0035640913
## ASV1502     -4.387407e-03 -0.0046200471 -0.0048609701 -0.0051101676
## ASV0195     -1.468402e-03 -0.0015717551 -0.0016799661 -0.0017931502
## ASV1213      9.625971e-03  0.0097936980  0.0099584980  0.0101201102
## ASV1648     -1.963475e-02 -0.0204507300 -0.0212992301 -0.0221814529
## ASV6984     -1.869203e-02 -0.0194816859 -0.0203034771 -0.0211586098
## ASV0396      5.832555e-04  0.0005973320  0.0006072646  0.0006123944
## ASV4297      1.571809e-02  0.0160806651  0.0164460463  0.0168142711
## ASV2622      2.873475e-02  0.0295626037  0.0304053157  0.0312629237
## ASV3512      2.265796e-02  0.0237874116  0.0249688118  0.0262041052
## ASV2411      2.862917e-02  0.0297577232  0.0309208911  0.0321189578
## ASV2291     -2.202420e-02 -0.0231381217 -0.0242975108 -0.0255033711
## ASV0807      3.007175e-02  0.0310135577  0.0319740683  0.0329532965
## ASV1292      4.108559e-03  0.0041679255  0.0042276072  0.0042878708
## ASV1035      2.412362e-02  0.0248385415  0.0255695587  0.0263170270
## ASV0070      2.962509e-03  0.0031526934  0.0033525072  0.0035622512
## ASV0255      6.335256e-04  0.0005575175  0.0004722106  0.0003769924
## ASV0057     -4.787427e-03 -0.0048490812 -0.0049071267 -0.0049613256
## ASV0077     -2.657213e-04 -0.0002444409 -0.0002225709 -0.0002002901
## ASV0625      1.234928e-02  0.0126420224  0.0129365937  0.0132328808
## ASV2464      8.562195e-02  0.0877919842  0.0899866854  0.0922055411
## ASV1315      3.820634e-02  0.0397403188  0.0413233303  0.0429560060
## ASV2673      3.318833e-02  0.0345454871  0.0359487329  0.0373989762
## ASV2161      1.429034e-02  0.0149018589  0.0155368231  0.0161959100
## ASV0337     -6.908073e-03 -0.0071654334 -0.0074308017 -0.0077043540
## ASV7680     -4.634614e-02 -0.0480862695 -0.0498784330 -0.0517233169
## ASV0611      2.655304e-02  0.0275944508  0.0286713389  0.0297846283
## ASV3118     -3.099775e-02 -0.0322663344 -0.0335772586 -0.0349312431
## ASV1284     -9.436533e-03 -0.0103977452 -0.0114231003 -0.0125155989
## ASV0889      1.591784e-02  0.0164536325  0.0170060135  0.0175756215
## ASV4649     -9.137755e-03 -0.0094688576 -0.0098099273 -0.0101611660
## ASV1108     -2.547939e-02 -0.0265968338 -0.0277557866 -0.0289571669
## ASV0738      1.840852e-02  0.0193421505  0.0203187640  0.0213399684
## ASV0473     -3.866662e-03 -0.0040069211 -0.0041468307 -0.0042857520
## ASV0598     -1.116555e-02 -0.0117706157 -0.0124046737 -0.0130687204
## ASV0429      9.389459e-03  0.0095877523  0.0097844752  0.0099793634
## ASV1549      3.083733e-02  0.0320905765  0.0333841888  0.0347186070
## ASV1203      1.668020e-02  0.0171679372  0.0176632709  0.0181660240
## ASV4532      3.079545e-04  0.0003321632  0.0003599736  0.0003917748
## ASV0274      4.414112e-03  0.0045662594  0.0047197458  0.0048742257
## ASV0163     -1.115771e-02 -0.0114692721 -0.0117880622 -0.0121143728
## ASV1298      1.568775e-03  0.0016811314  0.0018038363  0.0019376914
## ASV9424     -3.830382e-02 -0.0398680733 -0.0414901398 -0.0431717698
## ASV0412      2.825092e-02  0.0290787589  0.0299214717  0.0307790481
## ASV0284      1.794908e-03  0.0016795084  0.0015501836  0.0014061106
## ASV0620     -1.206582e-02 -0.0126428809 -0.0132432632 -0.0138675698
## ASV0153     -4.042129e-02 -0.0420272766 -0.0436827040 -0.0453880612
## ASV0498      1.162744e-02  0.0119842734  0.0123447149  0.0127082867
## ASV0097      8.105498e-03  0.0084349378  0.0087749495  0.0091256413
## ASV0104     -4.084771e-02 -0.0420815968 -0.0433363175 -0.0446115073
## ASV1282      9.807861e-03  0.0099125537  0.0100041465  0.0100815398
## ASV3883     -1.785196e-02 -0.0185941887 -0.0193585695 -0.0201450617
## ASV0801      7.106754e-03  0.0074057138  0.0077176784  0.0080432633
## ASV1611     -3.529618e-02 -0.0367201481 -0.0381921419 -0.0397130950
## ASV0227     -1.036710e-02 -0.0108814556 -0.0114173855 -0.0119755030
## ASV0833      1.030972e-02  0.0106713701  0.0110424250  0.0114229791
## ASV0718      4.635397e-02  0.0480144952  0.0497204907  0.0514724442
## ASV1139     -1.196926e-03 -0.0014601498 -0.0017416804 -0.0020421381
## ASV0766     -8.956747e-03 -0.0093320547 -0.0097189826 -0.0101175696
## ASV2091      2.544324e-02  0.0260047638  0.0265655550  0.0271251108
## ASV1238     -4.109860e-02 -0.0429088734 -0.0447970564 -0.0467662382
## ASV9193     -1.033250e-02 -0.0109512942 -0.0116022384 -0.0122865132
## ASV0290      1.925452e-03  0.0019596278  0.0019968054  0.0020374052
## ASV0231      1.064834e-02  0.0109199975  0.0111921946  0.0114645060
## ASV0185      1.386277e-02  0.0145566044  0.0152813252  0.0160379547
## ASV2330      9.843258e-03  0.0100574471  0.0102736353  0.0104919527
## ASV3119     -1.201061e-02 -0.0125960157 -0.0132065112 -0.0138428707
## ASV2368     -2.342086e-02 -0.0245027314 -0.0256318740 -0.0268099961
## ASV0122     -7.303522e-03 -0.0075313442 -0.0077640987 -0.0080018411
## ASV1044      2.564061e-02  0.0266962532  0.0277901529  0.0289233658
## ASV0160     -6.069856e-03 -0.0062251673 -0.0063841621 -0.0065471024
## ASV0326      2.137411e-03  0.0021910288  0.0022438952  0.0022958123
## ASV1388      3.797729e-02  0.0391292590  0.0403019483  0.0414951698
## ASV0792      2.442157e-02  0.0250475750  0.0256792156  0.0263162102
## ASV0036     -1.186015e-02 -0.0123104425 -0.0127724439 -0.0132460623
## ASV2125      2.819661e-02  0.0290747778  0.0299687786  0.0308783285
## ASV1075     -8.672829e-04 -0.0009258197 -0.0009884532 -0.0010554178
## ASV0390      2.154463e-02  0.0225009298  0.0234964274  0.0245324269
## ASV3790     -2.543567e-02 -0.0264006379 -0.0273958830 -0.0284219921
## ASV1535     -1.079714e-02 -0.0112898784 -0.0118003941 -0.0123289271
## ASV0263      2.847669e-02  0.0294670057  0.0304830604  0.0315250693
## ASV0675      4.896521e-02  0.0508704748  0.0528364213  0.0548641238
## ASV3348      4.831768e-03  0.0050328296  0.0052399776  0.0054532086
## ASV0058     -1.097274e-02 -0.0112935251 -0.0116191433 -0.0119494835
## ASV4142      1.326320e-02  0.0136030837  0.0139476398  0.0142969520
## ASV0059     -8.429895e-03 -0.0086626348 -0.0088981948 -0.0091364814
## ASV0013     -1.774418e-02 -0.0183459267 -0.0189626213 -0.0195944085
## ASV0033     -1.025175e-02 -0.0106443332 -0.0110477319 -0.0114619449
## ASV4354     -1.148867e-02 -0.0119316588 -0.0123889979 -0.0128609080
## ASV0022     -8.726314e-03 -0.0090662470 -0.0094160848 -0.0097758662
## ASV0134     -1.029424e-02 -0.0107833183 -0.0112946323 -0.0118291294
## ASV0415      1.993709e-03  0.0020748105  0.0021579210  0.0022430240
## ASV10103    -4.659721e-02 -0.0484144731 -0.0502889944 -0.0522216082
## ASV1613      2.238092e-02  0.0228862257  0.0233886204  0.0238872689
## ASV0135     -2.185929e-03 -0.0022111246 -0.0022344782 -0.0022558757
## ASV0469     -3.468104e-02 -0.0358089701 -0.0369660291 -0.0381528044
## ASV0471      2.326123e-02  0.0240839024  0.0249317494  0.0258055353
## ASV0451     -8.243522e-03 -0.0086520063 -0.0090761795 -0.0095162823
## ASV0747      1.366167e-02  0.0141219005  0.0145917643  0.0150711036
## ASV1314     -1.817897e-02 -0.0189905690 -0.0198351532 -0.0207137660
## ASV0425     -3.620198e-02 -0.0371379310 -0.0380853878 -0.0390442411
## ASV0559     -1.280614e-02 -0.0133397121 -0.0138957010 -0.0144749748
## ASV0148      9.598620e-04  0.0011221311  0.0012964919  0.0014835166
## ASV0129      9.598015e-03  0.0101696142  0.0107701208  0.0114005356
## ASV1072      6.737206e-04  0.0006094456  0.0005386689  0.0004611378
## ASV2390      1.434645e-02  0.0145083226  0.0146568246  0.0147911642
## ASV0548      1.516839e-02  0.0156519612  0.0161455104  0.0166490223
## ASV0168     -7.166534e-03 -0.0073845996 -0.0076072417 -0.0078345064
## ASV0066     -7.963558e-03 -0.0081785685 -0.0083947563 -0.0086118313
## ASV0468     -5.338730e-03 -0.0055465057 -0.0057618556 -0.0059850491
## ASV0172     -6.380501e-04 -0.0005860808 -0.0005284823 -0.0004649802
## ASV0236      7.325703e-03  0.0078208658  0.0083408014  0.0088861661
## ASV0250      2.114685e-02  0.0221716678  0.0232417701  0.0243587272
## ASV0338      6.834441e-03  0.0070540247  0.0072762113  0.0075007157
## ASV0450     -3.021287e-03 -0.0031903961 -0.0033676880 -0.0035534254
## ASV0377      9.928592e-03  0.0101981864  0.0104693459  0.0107416949
## ASV1022      4.340828e-04  0.0005020682  0.0005764108  0.0006575454
## ASV6174     -1.312128e-03 -0.0013796683 -0.0014478691 -0.0015163309
## ASV0786     -4.194037e-03 -0.0043909142 -0.0045932641 -0.0048009145
## ASV0053     -1.273861e-02 -0.0131749996 -0.0136220897 -0.0140799410
## ASV0697     -6.372972e-03 -0.0065704176 -0.0067734539 -0.0069823608
## ASV0785      1.422917e-02  0.0146635300  0.0151070454  0.0155598760
## ASV1967     -1.410953e-02 -0.0145502681 -0.0150003278 -0.0154596842
## ASV0385      6.458159e-03  0.0066824695  0.0069100882  0.0071406905
## ASV0295      3.639601e-03  0.0038590873  0.0040898074  0.0043321663
## ASV0072     -9.524440e-03 -0.0097386302 -0.0099511573 -0.0101616140
## ASV0157      2.680467e-03  0.0029328256  0.0032018818  0.0034883990
## ASV0501      2.762579e-02  0.0285426242  0.0294775042  0.0304300576
## ASV10729    -3.749324e-02 -0.0388899148 -0.0403279509 -0.0418079528
## ASV1470      1.005102e-02  0.0101515486  0.0102403426  0.0103165073
## ASV0050     -2.608434e-02 -0.0268554094 -0.0276385427 -0.0284334633
## ASV0411     -8.311598e-03 -0.0086654378 -0.0090335554 -0.0094165176
## ASV0549      1.211522e-02  0.0125706917  0.0130392977  0.0135211576
## ASV0184      3.737565e-03  0.0038898144  0.0040486788  0.0042144893
## ASV0705      5.236560e-03  0.0053413012  0.0054433859  0.0055424141
## ASV1715      1.506096e-02  0.0155749177  0.0161013810  0.0166404141
## ASV0603      3.561630e-03  0.0037528349  0.0039547531  0.0041679274
## ASV0826      2.390233e-02  0.0246934020  0.0255042900  0.0263352979
## ASV0034     -6.487573e-03 -0.0066555275 -0.0068247190 -0.0069950301
## ASV0838     -5.303425e-03 -0.0059407368 -0.0066271802 -0.0073655156
## ASV0614     -6.480942e-03 -0.0066921784 -0.0069084503 -0.0071298284
## ASV0014     -1.741607e-02 -0.0179775910 -0.0185509746 -0.0191361857
## ASV0585     -4.075814e-03 -0.0043812142 -0.0047001019 -0.0050324974
## ASV0016     -1.822889e-02 -0.0188182929 -0.0194203021 -0.0200349003
## ASV5394     -1.476187e-02 -0.0152613314 -0.0157708157 -0.0162899832
## ASV0666      2.435493e-02  0.0249855035  0.0256226586  0.0262662009
## ASV2085     -3.235746e-03 -0.0036734172 -0.0041399687 -0.0046365727
## ASV0003     -1.240155e-02 -0.0128029377 -0.0132130641 -0.0136319415
## ASV0346      7.831160e-03  0.0081159230  0.0084070071  0.0087042792
## ASV0267      1.664517e-03  0.0017448179  0.0018251330  0.0019049924
## ASV0353      1.243795e-02  0.0129280537  0.0134338055  0.0139554521
## ASV2419      2.526638e-02  0.0260260833  0.0267971799  0.0275791200
## ASV0447      1.825055e-02  0.0189668927  0.0197064583  0.0204697525
## ASV0654      2.153364e-02  0.0222170807  0.0229138243  0.0236237551
## ASV0151      5.669322e-03  0.0059487259  0.0062392937  0.0065412229
## ASV0065     -7.886082e-03 -0.0081273680 -0.0083732955 -0.0086238669
## ASV0527      2.029209e-02  0.0209404075  0.0216018620  0.0222763248
## ASV4055     -6.337216e-03 -0.0067047044 -0.0070944097 -0.0075076382
## ASV0166     -8.405206e-03 -0.0086216875 -0.0088406435 -0.0090620855
## ASV0417     -2.186185e-03 -0.0021932685 -0.0021974257 -0.0021985787
## ASV0078     -4.849240e-03 -0.0049495931 -0.0050477878 -0.0051434864
## ASV0322      2.338622e-03  0.0025733295  0.0028243647  0.0030924473
## ASV0156     -1.723666e-02 -0.0179126326 -0.0186120868 -0.0193357214
## ASV0648     -3.756985e-02 -0.0389961625 -0.0404646565 -0.0419757124
## ASV0407     -3.514654e-03 -0.0036784850 -0.0038495274 -0.0040280456
## ASV2030     -6.658392e-03 -0.0069834423 -0.0073250488 -0.0076838989
## ASV0300      4.964084e-03  0.0051592737  0.0053600896  0.0055665411
## ASV1150      1.528337e-03  0.0015904384  0.0016536396  0.0017178188
## ASV0958      1.675077e-02  0.0174983593  0.0182760733  0.0190848330
## ASV0216     -1.328291e-02 -0.0137892605 -0.0143153930 -0.0148621560
## ASV0446      2.259998e-02  0.0234244078  0.0242707724  0.0251391512
## ASV0367     -1.410204e-02 -0.0146084920 -0.0151288098 -0.0156631231
## ASV0200     -8.047552e-03 -0.0083134345 -0.0085842567 -0.0088598356
## ASV0334     -1.609581e-03 -0.0016192451 -0.0016297276 -0.0016413331
## ASV1311      1.961541e-03  0.0019165673  0.0018639450  0.0018032690
## ASV0458      2.974052e-03  0.0029384669  0.0028953557  0.0028444061
## ASV1371      1.606877e-03  0.0016560215  0.0017048469  0.0017531784
## ASV0418      1.356948e-02  0.0139174612  0.0142689608  0.0146238581
## ASV0004      1.840790e-03  0.0018830616  0.0019254517  0.0019679309
## ASV1943      2.115747e-02  0.0212446397  0.0213115860  0.0213579051
## ASV1495     -1.012912e-02 -0.0107068947 -0.0113126897 -0.0119473902
## ASV0901     -1.849637e-02 -0.0192781237 -0.0200904279 -0.0209343110
## ASV0628      4.233709e-03  0.0042476683  0.0042540531  0.0042523350
## ASV0400      3.340635e-03  0.0033836927  0.0034220613  0.0034552305
## ASV0116     -5.270230e-03 -0.0054837476 -0.0057048224 -0.0059336528
## ASV0788      4.765655e-02  0.0496390692  0.0516966373  0.0538317071
## ASV0117      3.981049e-03  0.0041518629  0.0043287762  0.0045119243
## ASV3137     -6.538948e-04 -0.0006617963 -0.0006683951 -0.0006735124
## ASV0001      1.877294e-03  0.0019170357  0.0019568510  0.0019967456
## ASV1651      5.920346e-03  0.0060735199  0.0062291185  0.0063872448
## ASV1692      3.855730e-02  0.0401049964  0.0417071210  0.0433652374
## ASV0660      4.906820e-03  0.0048361775  0.0047498258  0.0046469703
## ASV0508      1.918353e-04  0.0001823530  0.0001712104  0.0001582481
## ASV1660     -9.597993e-03 -0.0099974915 -0.0104086429 -0.0108313742
## ASV0233      1.045597e-02  0.0108302452  0.0112151142  0.0116107653
## ASV1343     -2.178805e-02 -0.0226668006 -0.0235770289 -0.0245196352
## ASV0209      6.246915e-03  0.0063646844  0.0064799584  0.0065924103
## ASV0193     -7.514748e-03 -0.0076546147 -0.0077907749 -0.0079227848
## ASV0357      8.444376e-03  0.0089087554  0.0093968555  0.0099096412
## ASV0198      7.518320e-03  0.0077702475  0.0080294262  0.0082960587
## ASV0007      1.431267e-03  0.0014522312  0.0014726450  0.0014925060
## ASV1772      6.194958e-04  0.0008756822  0.0011598071  0.0014740787
## ASV0009      9.925896e-04  0.0009989107  0.0010044165  0.0010091172
## ASV0006     -2.961921e-03 -0.0030865062 -0.0032153055 -0.0033483812
## ASV0011     -8.550886e-03 -0.0088755303 -0.0092102699 -0.0095552957
## ASV0015      6.767305e-04  0.0006735844  0.0006689827  0.0006628503
## ASV0017      8.409769e-04  0.0008444922  0.0008468955  0.0008481314
## ASV0235     -8.153960e-03 -0.0084749723 -0.0088071333 -0.0091507768
## ASV0382      5.165572e-03  0.0052804181  0.0053909332  0.0054963882
## ASV2357      2.601733e-02  0.0270270336  0.0280696539  0.0291458149
## ASV0567     -5.943807e-03 -0.0062249642 -0.0065195348 -0.0068281062
## ASV0165      4.103653e-03  0.0042482030  0.0043963517  0.0045481143
## ASV0005      5.177819e-03  0.0053365685  0.0054979323  0.0056618388
## ASV0384      1.597829e-03  0.0017389064  0.0018894691  0.0020500002
## ASV0002      8.679427e-04  0.0008946979  0.0009220792  0.0009500920
## ASV3017      2.156854e-02  0.0220585882  0.0225483844  0.0230374494
## ASV0091     -9.150048e-04 -0.0009649126 -0.0010181676 -0.0010750055
## ASV0186     -1.067995e-02 -0.0110060804 -0.0113367202 -0.0116716144
## ASV0370      5.228402e-03  0.0053909445  0.0055576240  0.0057285937
## ASV0018      6.829133e-03  0.0070471531  0.0072694565  0.0074960005
## ASV1377      5.657082e-02  0.0580426443  0.0595285951  0.0610280412
## ASV0019      7.248193e-03  0.0074834822  0.0077237166  0.0079688769
## ASV0023     -5.329035e-03 -0.0055258501 -0.0057277981 -0.0059348677
## ASV2194      9.910836e-03  0.0103452456  0.0107968688  0.0112662213
## ASV1155      2.562650e-02  0.0264485384  0.0272931376  0.0281610123
## ASV0510     -4.643683e-03 -0.0047371835 -0.0048326566 -0.0049303078
## ASV2371     -1.477208e-02 -0.0151887534 -0.0156111337 -0.0160390088
## ASV0024     -6.559583e-03 -0.0068012205 -0.0070492706 -0.0073037404
## ASV2452      1.032168e-02  0.0104326070  0.0105345628  0.0106270956
## ASV2332     -4.628162e-02 -0.0477803399 -0.0493164239 -0.0508904123
## ASV2591      1.957421e-02  0.0203256187  0.0210944575  0.0218804370
## ASV0521      1.364783e-02  0.0141795182  0.0147285668  0.0152953550
## ASV5542      1.241572e-02  0.0128680286  0.0133334561  0.0138122414
## ASV0336     -3.549872e-03 -0.0037402057 -0.0039396995 -0.0041487616
## ASV10102     2.296811e-02  0.0237904589  0.0246335702  0.0254974735
## ASV16823    -2.312978e-02 -0.0237077705 -0.0242924666 -0.0248837801
## ASV3104      1.196733e-01  0.1226633064  0.1256879346  0.1287467440
## ASV0781      2.307450e-02  0.0238858797  0.0247215855  0.0255822579
## ASV10899     2.389784e-02  0.0250518578  0.0262544018  0.0275069332
## ASV11222    -4.070774e-02 -0.0417246080 -0.0427532285 -0.0437934542
## ASV11327    -3.654688e-02 -0.0374596735 -0.0383830049 -0.0393167424
## ASV12458    -4.070452e-02 -0.0417210113 -0.0427492291 -0.0437890248
## ASV1636      2.704044e-02  0.0278296459  0.0286335190  0.0294521285
## ASV1890     -1.495031e-02 -0.0152418735 -0.0155364049 -0.0158342832
## ASV2898      3.653695e-02  0.0376138394  0.0387117766  0.0398310038
## ASV8328      2.106947e-02  0.0222940677  0.0235764323  0.0249182110
## ASV0709     -4.340947e-02 -0.0447327520 -0.0460806417 -0.0474529860
## ASV0856      4.870859e-02  0.0506218893  0.0525937122  0.0546247213
## ASV0909      2.430796e-02  0.0255329478  0.0268085673  0.0281360540
## ASV0937     -3.398013e-02 -0.0354143905 -0.0369047669 -0.0384530415
## ASV11390    -5.808863e-02 -0.0595387032 -0.0610054726 -0.0624887242
## ASV11966     2.569690e-02  0.0267241972  0.0277820314  0.0288705949
## ASV12990     1.111018e-02  0.0114129471  0.0117210859  0.0120346727
## ASV14797     1.585987e-02  0.0162790653  0.0167050429  0.0171378986
## ASV14904    -8.335164e-02 -0.0854319803 -0.0875362451 -0.0896641323
## ASV15304     1.855169e-02  0.0193374267  0.0201478556  0.0209831471
## ASV16696    -2.879866e-02 -0.0295173803 -0.0302443631 -0.0309795083
## ASV1690      7.880358e-02  0.0816330490  0.0845273591  0.0874857846
## ASV2029      4.341607e-02  0.0448170884  0.0462510400  0.0477182437
## ASV2834      6.235838e-02  0.0645303120  0.0667541791  0.0690299257
## ASV4003      7.200709e-02  0.0754258627  0.0789995426  0.0827344197
## ASV4064      3.086701e-02  0.0320009693  0.0331680036  0.0343687426
## ASV4294      2.798541e-02  0.0293201849  0.0307110307  0.0321596623
## ASV4609      1.497408e-02  0.0154972856  0.0160370498  0.0165938110
## ASV6283     -2.691937e-02 -0.0275911054 -0.0282705653 -0.0289576548
## ASV6491     -3.858311e-02 -0.0395458782 -0.0405197168 -0.0415044963
## ASV7453      3.519217e-02  0.0366311535  0.0381147928  0.0396434834
## ASV7959      1.886589e-02  0.0198189960  0.0208140933  0.0218525903
## ASV8219      3.334351e-01  0.3417552386  0.3501711633  0.3586817566
## ASV8547     -3.454268e-02 -0.0354046231 -0.0362764988 -0.0371581906
## ASV9319      2.602972e-02  0.0271180399  0.0282474483  0.0294192225
## ASV9382     -6.758695e-02 -0.0692734875 -0.0709794722 -0.0727046843
## ASV11516    -4.514251e-02 -0.0462690193 -0.0474085294 -0.0485608964
## ASV14377    -3.259531e-02 -0.0334087407 -0.0342315744 -0.0350637028
## ASV1867      3.961850e-02  0.0411390014  0.0427091833  0.0443303174
## ASV1895      9.127335e-03  0.0091456854  0.0091485781  0.0091352159
## ASV3168      1.547925e-02  0.0158026469  0.0161247074  0.0164451342
## ASV4449      1.239564e-01  0.1284525742  0.1330881925  0.1378667631
## ASV6596      3.906431e-02  0.0408883836  0.0427876588  0.0447642798
## ASV7492      6.083198e-03  0.0065905829  0.0071243823  0.0076852294
## ASV9854     -6.591890e-03 -0.0067461296 -0.0069014097 -0.0070576698
## ASV6296      5.469753e-01  0.5606274213  0.5744377412  0.5884046102
## ASV4201      1.652018e-02  0.0175222233  0.0185760951  0.0196838337
## ASV0552      2.614836e-02  0.0270757897  0.0280258513  0.0289984257
## ASV3671     -1.750949e-02 -0.0182600906 -0.0190448318 -0.0198652618
## ASV3529      2.744266e-03  0.0029722540  0.0032081121  0.0034516438
## ASV1060      9.128211e-03  0.0095615070  0.0100148841  0.0104891837
## ASV0239     -5.331511e-03 -0.0054202125 -0.0055067695 -0.0055909677
## ASV5711     -3.564312e-02 -0.0367845140 -0.0379518653 -0.0391452541
## ASV4152     -5.756671e-02 -0.0595670118 -0.0616156784 -0.0637125833
## ASV1461      1.796012e-02  0.0182917614  0.0186197566  0.0189437480
## ASV2877      9.664026e-03  0.0098323259  0.0099958101  0.0101539532
## ASV0012      2.573589e-03  0.0026650892  0.0027591649  0.0028558522
## ASV9823     -1.575656e-03 -0.0018272977 -0.0020975972 -0.0023873704
## ASV0008      2.672914e-03  0.0027666878  0.0028630936  0.0029621710
## ASV7832     -3.636120e-02 -0.0377374722 -0.0391555814 -0.0406161505
## ASV1915     -4.437241e-03 -0.0046326188 -0.0048368740 -0.0050503440
## ASV0055     -4.848178e-03 -0.0050807111 -0.0053230819 -0.0055756048
## ASV0032      3.826652e-04  0.0003752973  0.0003676858  0.0003599506
## ASV2977     -4.643937e-02 -0.0479996479 -0.0495940699 -0.0512223099
## ASV0466      2.359843e-02  0.0239959467  0.0243836138  0.0247606149
## ASV3866      3.066252e-02  0.0319236591  0.0332316556  0.0345879409
## ASV0040      9.823750e-03  0.0101797905  0.0105457396  0.0109216976
## ASV0496     -7.994784e-03 -0.0084385416 -0.0089009101 -0.0093821888
## ASV0052      8.348596e-03  0.0086592922  0.0089797718  0.0093102871
## ASV3828     -1.902435e-02 -0.0194832617 -0.0199463877 -0.0204136180
## ASV1930      1.018170e-02  0.0104059760  0.0106296632  0.0108525606
## ASV2126      2.194944e-02  0.0226780756  0.0234259843  0.0241935371
## ASV0793      3.287581e-02  0.0341358501  0.0354362032  0.0367778340
## ASV0299     -2.121102e-03 -0.0022930420 -0.0024780790 -0.0026770052
## ASV0208      2.273867e-02  0.0236084256  0.0245074865  0.0254366740
## ASV0511     -5.119323e-03 -0.0052198817 -0.0053219464 -0.0054257245
## ASV1123     -1.683946e-02 -0.0171531003 -0.0174605308 -0.0177608211
## ASV0099      1.927569e-03  0.0020424476  0.0021634770  0.0022908919
## ASV0752     -1.913594e-02 -0.0199407110 -0.0207751601 -0.0216401185
## ASV0883      2.490912e-02  0.0258740569  0.0268664461  0.0278863659
## ASV0683      3.176207e-02  0.0330183144  0.0343154803  0.0356543214
## ASV4117     -4.685467e-02 -0.0486632877 -0.0505318509 -0.0524617536
## ASV2172     -1.846473e-04 -0.0003002000 -0.0004257740 -0.0005619117
## ASV0330     -9.085130e-03 -0.0094475576 -0.0098231129 -0.0102122166
## ASV0728      3.807816e-02  0.0393504817  0.0406547551  0.0419914792
## ASV0499      1.280836e-02  0.0133313598  0.0138724042  0.0144318827
## ASV0120     -1.675639e-02 -0.0172868534 -0.0178266350 -0.0183754473
## ASV1446      3.033287e-03  0.0027949745  0.0025302691  0.0022377686
## ASV17171    -3.528919e-02 -0.0366268032 -0.0380092855 -0.0394377897
## ASV0533      3.715428e-03  0.0038795258  0.0040494700  0.0042253513
## ASV2495     -1.516368e-02 -0.0159105666 -0.0166872832 -0.0174943720
## ASV5582      6.643562e-03  0.0066028729  0.0065465668  0.0064736452
## ASV1488      3.860866e-03  0.0039000898  0.0039335222  0.0039606574
## ASV0682      9.425169e-03  0.0098033018  0.0101933725  0.0105955139
## ASV0068     -1.296214e-02 -0.0133724403 -0.0137891738 -0.0142120167
## ASV1987     -4.251608e-02 -0.0442792756 -0.0461029883 -0.0479883935
## ASV0035     -7.509388e-03 -0.0079784953 -0.0084743521 -0.0089981792
## ASV7192     -1.768527e-02 -0.0181942600 -0.0187094762 -0.0192305091
## ASV0873     -5.575856e-02 -0.0589429197 -0.0622516228 -0.0656860579
## ASV4749     -1.277071e-02 -0.0135933614 -0.0144567761 -0.0153621473
## ASV2174      6.516642e-03  0.0064990544  0.0064687719  0.0064252069
## ASV1476     -1.902945e-02 -0.0198472335 -0.0206953368 -0.0215744980
## ASV0740     -5.179143e-02 -0.0539677020 -0.0562257713 -0.0585680925
## ASV0170     -8.521127e-03 -0.0088348152 -0.0091582532 -0.0094916725
## ASV2466     -3.993741e-02 -0.0414501205 -0.0430110738 -0.0446212580
## ASV1709      1.426712e-02  0.0149225313  0.0156140108  0.0163437694
## ASV6170     -6.737197e-02 -0.0700190298 -0.0727520201 -0.0755724858
## ASV3673      3.493313e-02  0.0363485203  0.0378110040  0.0393213766
## ASV1745     -1.091018e-02 -0.0114006610 -0.0119096917 -0.0124376874
##                                                                    
## (Intercept)  0.2217962628  0.2288204920  2.359824e-01  2.432806e-01
## ASV1236      0.0357371963  0.0367193554  3.771711e-02  3.873041e-02
## ASV0421      0.0107474924  0.0112182476  1.170223e-02  1.219936e-02
## ASV0691     -0.0161821588 -0.0163490312 -1.650955e-02 -1.666359e-02
## ASV0899      0.0294870050  0.0302069296  3.093364e-02  3.166710e-02
## ASV1004      0.0708606167  0.0727405428  7.464611e-02  7.657702e-02
## ASV1041     -0.0245972135 -0.0250028425 -2.539596e-02 -2.577561e-02
## ASV1058      0.0447422228  0.0459750668  4.722847e-02  4.850242e-02
## ASV12542     0.0153963236  0.0157990896  1.621037e-02  1.663043e-02
## ASV1294      0.0423540759  0.0435637085  4.479768e-02  4.605638e-02
## ASV13113     0.0250557221  0.0261639240  2.731550e-02  2.851166e-02
## ASV1318      0.0411880824  0.0423066390  4.344375e-02  4.459960e-02
## ASV2269     -0.0668404300 -0.0684003513 -6.996642e-02 -7.153787e-02
## ASV2542      0.0511687175  0.0531480128  5.519171e-02  5.730117e-02
## ASV2660     -0.0263378326 -0.0269761535 -2.762055e-02 -2.827095e-02
## ASV2737      0.0076080665  0.0077883133  7.972373e-03  8.160364e-03
## ASV2840      0.0280673425  0.0285073750  2.893887e-02  2.936139e-02
## ASV3053      0.1745077424  0.1788745734  1.833042e-01  1.877969e-01
## ASV3077      0.0118625028  0.0121963826  1.253762e-02  1.288636e-02
## ASV3134      0.0368681104  0.0384326943  4.005578e-02  4.173890e-02
## ASV3140      0.0370926795  0.0382863844  3.950501e-02  4.074849e-02
## ASV3579      0.0208829584  0.0217837998  2.271400e-02  2.367375e-02
## ASV6119     -0.0182825763 -0.0187104442 -1.914040e-02 -1.957226e-02
## ASV7557     -0.0371536513 -0.0380239965 -3.889875e-02 -3.977756e-02
## ASV8422      0.0093397242  0.0096062935  9.879560e-03  1.015973e-02
## ASV1086     -0.0011112315 -0.0011501922 -1.191229e-03 -1.234415e-03
## ASV1310      0.0183695601  0.0188283159  1.929086e-02  1.975694e-02
## ASV15750    -0.0011545130 -0.0011312339 -1.104508e-03 -1.074221e-03
## ASV16905    -0.0076420311 -0.0078217480 -8.002475e-03 -8.184137e-03
## ASV2033      0.0514196791  0.0533186146  5.527138e-02  5.727880e-02
## ASV2089      0.0161534713  0.0165324659  1.691344e-02  1.729622e-02
## ASV2127      0.0555743519  0.0570749504  5.859908e-02  6.014670e-02
## ASV2725      0.0396387910  0.0405545804  4.147690e-02  4.240547e-02
## ASV2804     -0.0158245884 -0.0161976014 -1.657279e-02 -1.694997e-02
## ASV3075      0.0490175125  0.0508680141  5.278161e-02  5.475996e-02
## ASV3327      0.0708090266  0.0733380546  7.593610e-02  7.860410e-02
## ASV3342      0.0600156097  0.0621894961  6.442724e-02  6.673002e-02
## ASV3532     -0.0639438947 -0.0663040334 -6.874410e-02 -7.126668e-02
## ASV3600      0.0295414510  0.0305687173  3.162285e-02  3.270408e-02
## ASV4013      0.0462424646  0.0475746159  4.892718e-02  5.029970e-02
## ASV4136      0.0426288421  0.0437574720  4.490432e-02  4.606944e-02
## ASV4195      0.1616137249  0.1654328765  1.692747e-01  1.731371e-01
## ASV4407     -0.0624524105 -0.0639290549 -6.541443e-02 -6.690770e-02
## ASV4717      0.0082128239  0.0083966819  8.585240e-03  8.778824e-03
## ASV6794      0.0245756213  0.0252289837  2.589597e-02  2.657692e-02
## ASV8324     -0.0320558645 -0.0328149188 -3.357847e-02 -3.434607e-02
## ASV8981      0.0029592361  0.0031765442  3.404638e-03  3.643773e-03
## ASV9859      0.0280262334  0.0294531263  3.094672e-02  3.250951e-02
## ASV0936      0.0428593038  0.0442534646  4.567606e-02  4.712686e-02
## ASV12683    -0.0003901853 -0.0003833948 -3.739033e-04 -3.614594e-04
## ASV1293      0.0210382858  0.0215647021  2.209686e-02  2.263464e-02
## ASV13055     0.0021052355  0.0022564905  2.415377e-03  2.582150e-03
## ASV17063    -0.0166435474 -0.0170379608 -1.743458e-02 -1.783313e-02
## ASV2228      0.0135750127  0.0138967663  1.422031e-02  1.454541e-02
## ASV2769      0.0051173209  0.0053171489  5.520757e-03  5.727971e-03
## ASV2803      0.0122216331  0.0124801018  1.274116e-02  1.300494e-02
## ASV2896      0.0199226840  0.0207846408  2.168258e-02  2.261790e-02
## ASV3062      0.0270276438  0.0281313488  2.926887e-02  3.044050e-02
## ASV3107      0.0328207077  0.0340499920  3.531697e-02  3.662229e-02
## ASV3265      0.0294372396  0.0301514526  3.087203e-02  3.159871e-02
## ASV3666     -0.0004742616 -0.0005159693 -5.597699e-04 -6.056618e-04
## ASV4497      0.0112147602  0.0115278713  1.184628e-02  1.217002e-02
## ASV6914     -0.0038370798 -0.0040048887 -4.178000e-03 -4.356422e-03
## ASV0576     -0.0274016890 -0.0278726805 -2.834001e-02 -2.880338e-02
## ASV0673      0.0453912746  0.0467242242  4.808394e-02  4.947076e-02
## ASV0772      0.0232895836  0.0240703833  2.487286e-02  2.569751e-02
## ASV0862      0.0099902691  0.0104574323  1.093682e-02  1.142812e-02
## ASV0898      0.0225671565  0.0233846161  2.422353e-02  2.508410e-02
## ASV0910      0.0250070150  0.0259421228  2.690554e-02  2.789774e-02
## ASV0964     -0.0111272541 -0.0113421169 -1.155725e-02 -1.177270e-02
## ASV10059     0.0211414042  0.0220060373  2.289906e-02  2.382092e-02
## ASV10263    -0.0253585512 -0.0259607499 -2.656623e-02 -2.717457e-02
## ASV1088      0.0445558634  0.0462996275  4.810426e-02  4.997142e-02
## ASV1101      0.0359674529  0.0368387129  3.771792e-02  3.860488e-02
## ASV1183      0.0130653434  0.0135250551  1.399853e-02  1.448611e-02
## ASV11956     0.0074436865  0.0076116423  7.783135e-03  7.958377e-03
## ASV12774    -0.0022145508 -0.0023587599 -2.508973e-03 -2.665253e-03
## ASV1321      0.0665267427  0.0689942187  7.152961e-02  7.413333e-02
## ASV13793    -0.0174883489 -0.0179036842 -1.832130e-02 -1.874095e-02
## ASV14482     0.0011021763  0.0011533236  1.207454e-03  1.264707e-03
## ASV15483     0.0103129053  0.0106702975  1.103697e-02  1.141307e-02
## ASV2062      0.0403739339  0.0416336940  4.292199e-02  4.423906e-02
## ASV2132      0.0389548129  0.0402958274  4.166935e-02  4.307544e-02
## ASV2413      0.0287562492  0.0296022607  3.046692e-02  3.135059e-02
## ASV2490      0.0731193193  0.0747786446  7.645036e-02  7.813410e-02
## ASV2594      0.0154252780  0.0160583768  1.671612e-02  1.739932e-02
## ASV2822     -0.0461478184 -0.0472445037 -4.834745e-02 -4.945608e-02
## ASV2863      0.0496203018  0.0509193955  5.223790e-02  5.357579e-02
## ASV2910      0.0186212614  0.0191196875  1.962651e-02  2.014182e-02
## ASV2980      0.0238183592  0.0245325507  2.526079e-02  2.600313e-02
## ASV3307      0.0367306936  0.0376044058  3.848339e-02  3.936724e-02
## ASV3474      0.0401335479  0.0416757028  4.326341e-02  4.489716e-02
## ASV3502      0.0339365776  0.0351080523  3.631346e-02  3.755362e-02
## ASV4236      0.0320866455  0.0327271607  3.336824e-02  3.400968e-02
## ASV4842     -0.0037326571 -0.0037518178 -3.764321e-03 -3.769820e-03
## ASV4894     -0.0174974022 -0.0179141636 -1.833357e-02 -1.875546e-02
## ASV5290      0.0192022877  0.0198614434  2.053863e-02  2.123426e-02
## ASV5501      0.0133522302  0.0139272433  1.452688e-02  1.515206e-02
## ASV5795      0.0132852020  0.0137400631  1.420562e-02  1.468184e-02
## ASV5987     -0.0488793881 -0.0500455335 -5.121951e-02 -5.240091e-02
## ASV6267     -0.0550858232 -0.0564010121 -5.772524e-02 -5.905810e-02
## ASV6862      0.0212284381  0.0217670399  2.231396e-02  2.286925e-02
## ASV7145      0.0101210118  0.0104462230  1.078153e-02  1.112717e-02
## ASV7673     -0.0175068505 -0.0179254339 -1.834700e-02 -1.877144e-02
## ASV7789      0.0197622667  0.0206824358  2.163912e-02  2.263325e-02
## ASV7809      0.0039546830  0.0041566322  4.365343e-03  4.580802e-03
## ASV8002     -0.0221189949 -0.0226491693 -2.318336e-02 -2.372143e-02
## ASV8205      0.0131092709  0.0135749092  1.405305e-02  1.454376e-02
## ASV9155     -0.0045076394 -0.0045736027 -4.637513e-03 -4.699277e-03
## ASV9221      0.0094293922  0.0099403819  1.047431e-02  1.103188e-02
## ASV9311     -0.0355070787 -0.0363614356 -3.722275e-02 -3.809084e-02
## ASV9557     -0.0242730297 -0.0248577758 -2.544737e-02 -2.604170e-02
## ASV9936     -0.0489637387 -0.0501447235 -5.133568e-02 -5.253638e-02
## ASV1445      0.0409002731  0.0422895974  4.371265e-02  4.516953e-02
## ASV4232      0.0229301692  0.0240313478  2.518320e-02  2.638770e-02
## ASV6479      0.0143631445  0.0151327692  1.593712e-02  1.677722e-02
## ASV0142     -0.0211754353 -0.0217198804 -2.227194e-02 -2.283162e-02
## ASV0378      0.0164153567  0.0170263358  1.765185e-02  1.829171e-02
## ASV1122      0.0418217836  0.0433289684  4.487903e-02  4.647259e-02
## ASV0123     -0.0183881973 -0.0188469852 -1.931115e-02 -1.978062e-02
## ASV2064      0.0051021500  0.0050417801  4.967908e-03  4.879899e-03
## ASV4459     -0.0007702591 -0.0008128344 -8.603730e-04 -9.132920e-04
## ASV0448      0.0135182492  0.0140532680  1.460440e-02  1.517178e-02
## ASV0397      0.0208272035  0.0214697780  2.212563e-02  2.279482e-02
## ASV0485      0.0228146030  0.0234967426  2.419268e-02  2.490249e-02
## ASV1566      0.0352608165  0.0363413517  3.744362e-02  3.856762e-02
## ASV1365      0.0311399089  0.0320705617  3.301599e-02  3.397595e-02
## ASV1065      0.0457703544  0.0472561891  4.877543e-02  5.032818e-02
## ASV0722     -0.0037922059 -0.0039833591 -4.183859e-03 -4.394082e-03
## ASV12660    -0.0194156882 -0.0198828624 -2.035468e-02 -2.083105e-02
## ASV0223      0.0067771350  0.0070060527  7.241740e-03  7.484364e-03
## ASV0229      0.0125417485  0.0130225363  1.351971e-02  1.403374e-02
## ASV0877     -0.0009603409 -0.0012412951 -1.547033e-03 -1.878917e-03
## ASV0983      0.0210271002  0.0215847399  2.214896e-02  2.271954e-02
## ASV0626      0.0076056947  0.0079581156  8.321923e-03  8.697231e-03
## ASV4146     -0.0018004108 -0.0020458014 -2.312104e-03 -2.600422e-03
## ASV4175     -0.0335594645 -0.0346952678 -3.585749e-02 -3.704611e-02
## ASV2082     -0.0301187107 -0.0316352479 -3.321566e-02 -3.486153e-02
## ASV2272      0.0166506511  0.0172710348  1.791097e-02  1.857088e-02
## ASV2245     -0.0246311229 -0.0254769928 -2.634278e-02 -2.722846e-02
## ASV0590     -0.0310219084 -0.0326008933 -3.424722e-02 -3.596271e-02
## ASV0217      0.0091421281  0.0096465802  1.017188e-02  1.071855e-02
## ASV0416      0.0066582222  0.0065890586  6.505280e-03  6.406364e-03
## ASV1056      0.0256809501  0.0266029971  2.754805e-02  2.851610e-02
## ASV7777     -0.0338682749 -0.0351660382 -3.651195e-02 -3.790799e-02
## ASV0455      0.0050763674  0.0052143721  5.353044e-03  5.492172e-03
## ASV0604      0.0181942332  0.0188917941  1.960999e-02  2.034907e-02
## ASV6100     -0.0254593318 -0.0264892112 -2.755835e-02 -2.866816e-02
## ASV11359    -0.0459855966 -0.0474420305 -4.892529e-02 -5.043485e-02
## ASV6604      0.0076969147  0.0079701178  8.248572e-03  8.532004e-03
## ASV5004     -0.0168614028 -0.0174671704 -1.809205e-02 -1.873651e-02
## ASV1483     -0.0065038267 -0.0066965861 -6.892111e-03 -7.090236e-03
## ASV9773     -0.0230222024 -0.0238869375 -2.478003e-02 -2.570224e-02
## ASV4059      0.0063542539  0.0067086128  7.074232e-03  7.450807e-03
## ASV1193      0.0238801335  0.0246479060  2.543327e-02  2.623631e-02
## ASV4610      0.0025833288  0.0027635966  2.947027e-03  3.133192e-03
## ASV0742      0.0037990616  0.0040416037  4.291567e-03  4.548784e-03
## ASV1502     -0.0053676097 -0.0056332429 -5.906990e-03 -6.188750e-03
## ASV0195     -0.0019114229 -0.0020348999 -2.163699e-03 -2.297938e-03
## ASV1213      0.0102782699  0.0104327080  1.058315e-02  1.072932e-02
## ASV1648     -0.0230986287 -0.0240520133 -2.504289e-02 -2.607255e-02
## ASV6984     -0.0220483133 -0.0229738426 -2.393648e-02 -2.493752e-02
## ASV0396      0.0006120113  0.0006053528  5.916024e-04  5.698881e-04
## ASV4297      0.0171854020  0.0175595266  1.793676e-02  1.831724e-02
## ASV2622      0.0321354636  0.0330229721  3.392549e-02  3.484305e-02
## ASV3512      0.0274952745  0.0288443425  3.025337e-02  3.172446e-02
## ASV2411      0.0333521542  0.0346206501  3.592455e-02  3.726389e-02
## ASV2291     -0.0267566788 -0.0280583865 -2.940942e-02 -3.081069e-02
## ASV0807      0.0339512688  0.0349680222  3.600361e-02  3.705809e-02
## ASV1292      0.0043490138  0.0044113650  4.475284e-03  4.541163e-03
## ASV1035      0.0270813144  0.0278628026  2.866189e-02  2.947898e-02
## ASV0070      0.0037822241  0.0040127213  4.254035e-03  4.506452e-03
## ASV0255      0.0002712290  0.0001542659  2.542804e-05 -1.159782e-04
## ASV0057     -0.0050114413 -0.0050572392 -5.098487e-03 -5.134956e-03
## ASV0077     -0.0001778025 -0.0001553388 -1.331574e-04 -1.115463e-04
## ASV0625      0.0135307706  0.0138301552  1.413093e-02  1.443300e-02
## ASV2464      0.0944480296  0.0967136174  9.900176e-02  1.013119e-01
## ASV1315      0.0446389215  0.0463725930  4.815747e-02  4.999395e-02
## ASV2673      0.0388971005  0.0404439647  4.204040e-02  4.368721e-02
## ASV2161      0.0168797961  0.0175891575  1.832467e-02  1.908700e-02
## ASV0337     -0.0079862657 -0.0082767117 -8.575865e-03 -8.883898e-03
## ASV7680     -0.0536215533 -0.0555737149 -5.758031e-02 -5.964178e-02
## ASV0611      0.0309352495  0.0321241431  3.335226e-02  3.462055e-02
## ASV3118     -0.0363289834 -0.0377711437 -3.925836e-02 -4.079122e-02
## ASV1284     -0.0136783181 -0.0149144094 -1.622710e-02 -1.761967e-02
## ASV0889      0.0181631313  0.0187692526  1.939473e-02  2.004034e-02
## ASV4649     -0.0105227734 -0.0108949461 -1.127788e-02 -1.167176e-02
## ASV1108     -0.0302018724 -0.0314907770 -3.282473e-02 -3.420455e-02
## ASV0738      0.0224074090  0.0235227708  2.468778e-02  2.590419e-02
## ASV0473     -0.0044229870 -0.0045577771 -4.689301e-03 -4.816671e-03
## ASV0598     -0.0137637503 -0.0144907582 -1.525074e-02 -1.604467e-02
## ASV0429      0.0101721595  0.0103626140  1.055049e-02  1.073555e-02
## ASV1549      0.0360942077  0.0375112991  3.897012e-02  4.047082e-02
## ASV1203      0.0186760054  0.0191930120  1.971683e-02  2.024723e-02
## ASV4532      0.0004279813  0.0004690334  5.153970e-04  5.675638e-04
## ASV0274      0.0050293241  0.0051846369  5.339730e-03  5.494139e-03
## ASV0163     -0.0124485123 -0.0127908077 -1.314160e-02 -1.350127e-02
## ASV1298      0.0020835334  0.0022422324  2.414691e-03  2.601843e-03
## ASV9424     -0.0449147392 -0.0467208454 -4.859191e-02 -5.052975e-02
## ASV0412      0.0316514817  0.0325387691  3.344091e-02  3.435792e-02
## ASV0284      0.0012464363  0.0010702767  8.767175e-04  6.648141e-04
## ASV0620     -0.0145164025 -0.0151903586 -1.589003e-02 -1.661601e-02
## ASV0153     -0.0471437784 -0.0489502228 -5.080770e-02 -5.271643e-02
## ASV0498      0.0130744835  0.0134427723  1.381259e-02  1.418336e-02
## ASV0097      0.0094871033  0.0098594074  1.024261e-02  1.063673e-02
## ASV0104     -0.0459067754 -0.0472217095 -4.855588e-02 -4.990883e-02
## ASV1282      0.0101436040  0.0101891812  1.021709e-02  1.022611e-02
## ASV3883     -0.0209535618 -0.0217839058 -2.263587e-02 -2.350915e-02
## ASV0801      0.0083831087  0.0087378781  9.108259e-03  9.494960e-03
## ASV1611     -0.0412839147 -0.0429054780 -4.457863e-02 -4.630418e-02
## ASV0227     -0.0125564316 -0.0131607999 -1.378924e-02 -1.444240e-02
## ASV0833      0.0118131260  0.0122129562  1.262256e-02  1.304201e-02
## ASV0718      0.0532708060  0.0551159925  5.700839e-02  5.894833e-02
## ASV1139     -0.0023621316 -0.0027022557 -3.063090e-03 -3.445194e-03
## ASV0766     -0.0105278329 -0.0109497668 -1.138334e-02 -1.182851e-02
## ASV2091      0.0276829313  0.0282385263  2.879142e-02  2.934114e-02
## ASV1238     -0.0488195798 -0.0509603164 -5.319175e-02 -5.551727e-02
## ASV9193     -0.0130053105 -0.0137598257 -1.455126e-02 -1.538080e-02
## ASV0290      0.0020818692  0.0021306588  2.184253e-03  2.243147e-03
## ASV0231      0.0117364898  0.0120076847  1.227761e-02  1.254577e-02
## ASV0185      0.0168275324  0.0176511087  1.850974e-02  1.940451e-02
## ASV2330      0.0107125458  0.0109355765  1.116122e-02  1.138967e-02
## ASV3119     -0.0145058676 -0.0151962760 -1.591487e-02 -1.666242e-02
## ASV2368     -0.0280388341 -0.0293201448 -3.065570e-02 -3.204729e-02
## ASV0122     -0.0082446314 -0.0084925344 -8.745620e-03 -9.003964e-03
## ASV1044      0.0300969596  0.0313120106  3.256960e-02  3.387083e-02
## ASV0160     -0.0067142707 -0.0068859709 -7.062528e-03 -7.244286e-03
## ASV0326      0.0023465715  0.0023959531  2.443726e-03  2.489649e-03
## ASV1388      0.0427087286  0.0439424207  4.519603e-02  4.646935e-02
## ASV0792      0.0269582833  0.0276051661  2.825660e-02  2.891233e-02
## ASV0036     -0.0137311702 -0.0142276084 -1.473518e-02 -1.525367e-02
## ASV2125      0.0318031119  0.0327427859  3.369698e-02  3.466530e-02
## ASV1075     -0.0011269536 -0.0012033055 -1.284723e-03 -1.371458e-03
## ASV0390      0.0256102507  0.0267312359  2.789673e-02  2.910810e-02
## ASV3790     -0.0294795448 -0.0305691108 -3.169125e-02 -3.284651e-02
## ASV1535     -0.0128756942 -0.0134408880 -1.402468e-02 -1.462720e-02
## ASV0263      0.0325932281  0.0336877109  3.480867e-02  3.595624e-02
## ASV0675      0.0569546234  0.0591089273  6.132801e-02  6.361279e-02
## ASV3348      0.0056725036  0.0058978264  6.129122e-03  6.366316e-03
## ASV0058     -0.0122844244 -0.0126238405 -1.296760e-02 -1.331557e-02
## ASV4142      0.0146511157  0.0150102411  1.537445e-02  1.574389e-02
## ASV0059     -0.0093774021 -0.0096208660 -9.866784e-03 -1.011507e-02
## ASV0013     -0.0202414279 -0.0209038160 -2.158171e-02 -2.227523e-02
## ASV0033     -0.0118869482 -0.0123226965 -1.276912e-02 -1.322614e-02
## ASV4354     -0.0133475871 -0.0138492114 -1.436593e-02 -1.489789e-02
## ASV0022     -0.0101456115 -0.0105253215 -1.091498e-02 -1.131453e-02
## ASV0134     -0.0123877886 -0.0129716247 -1.358169e-02 -1.421907e-02
## ASV0415      0.0023301026  0.0024191394  2.510117e-03  2.603020e-03
## ASV10103    -0.0542130885 -0.0562641495 -5.837544e-02 -6.054755e-02
## ASV1613      0.0243813168  0.0248698973  2.535213e-02  2.582714e-02
## ASV0135     -0.0022752033 -0.0022923473 -2.307194e-03 -2.319631e-03
## ASV0469     -0.0393698944 -0.0406179076 -4.189746e-02 -4.320919e-02
## ASV0471      0.0267060621  0.0276341666  2.859072e-02  2.957664e-02
## ASV0451     -0.0099725376 -0.0104451502 -1.093431e-02 -1.144017e-02
## ASV0747      0.0155597434  0.0160574885  1.656412e-02  1.707941e-02
## ASV1314     -0.0216274565 -0.0225772810 -2.356430e-02 -2.458958e-02
## ASV0425     -0.0400143904 -0.0409957437 -4.198822e-02 -4.299174e-02
## ASV0559     -0.0150784118 -0.0157068981 -1.636132e-02 -1.704258e-02
## ASV0148      0.0016837910  0.0018979144  2.126500e-03  2.370175e-03
## ASV0129      0.0120618618  0.0127551028  1.348126e-02  1.424133e-02
## ASV1072      0.0003766061  0.0002848358  1.855981e-04  7.867513e-05
## ASV2390      0.0149105664  0.0150142723  1.510154e-02  1.517165e-02
## ASV0548      0.0171624803  0.0176858649  1.821915e-02  1.876233e-02
## ASV0168     -0.0080664413 -0.0083030953 -8.544519e-03 -8.790765e-03
## ASV0066     -0.0088294874 -0.0090474022 -9.265238e-03 -9.482640e-03
## ASV0468     -0.0062163644 -0.0064560879 -6.704514e-03 -6.961944e-03
## ASV0172     -0.0003952964 -0.0003191492 -2.362540e-04 -1.463236e-04
## ASV0236      0.0094575974  0.0100557113  1.068110e-02  1.133433e-02
## ASV0250      0.0255241362  0.0267396161  2.800681e-02  2.932736e-02
## ASV0338      0.0077272323  0.0079554343  8.184974e-03  8.415482e-03
## ASV0450     -0.0037478674 -0.0039512680 -4.163874e-03 -4.385925e-03
## ASV0377      0.0110148354  0.0112883472  1.156179e-02  1.183470e-02
## ASV1022      0.0007459258  0.0008420248  9.463343e-04  1.059365e-03
## ASV6174     -0.0015846003 -0.0016521678 -1.718466e-03 -1.782866e-03
## ASV0786     -0.0050136634 -0.0052312766 -5.453487e-03 -5.679996e-03
## ASV0053     -0.0145486092 -0.0150281444 -1.551859e-02 -1.601999e-02
## ASV0697     -0.0071974438 -0.0074190360 -7.647500e-03 -7.883227e-03
## ASV0785      0.0160221986  0.0164942102  1.697613e-02  1.746820e-02
## ASV1967     -0.0159282999 -0.0164061219 -1.689308e-02 -1.738909e-02
## ASV0385      0.0073739222  0.0076093997  7.846710e-03  8.085411e-03
## ASV0295      0.0045865731  0.0048534405  5.133184e-03  5.426221e-03
## ASV0072     -0.0103695845 -0.0105746450 -1.077637e-02 -1.097431e-02
## ASV0157      0.0037931557  0.0041169451  4.460574e-03  4.824862e-03
## ASV0501      0.0313998805  0.0323865365  3.338956e-02  3.440846e-02
## ASV10729    -0.0433305089 -0.0448961861 -4.650553e-02 -4.815906e-02
## ASV1470      0.0103791218  0.0104272422  1.045990e-02  1.047611e-02
## ASV0050     -0.0292398774 -0.0300574763 -3.088594e-02 -3.172493e-02
## ASV0411     -0.0098149149 -0.0102293621 -1.066050e-02 -1.110899e-02
## ASV0549      0.0140163773  0.0145250461  1.504724e-02  1.558300e-02
## ASV0184      0.0043875941  0.0045683589  4.757168e-03  4.954424e-03
## ASV0705      0.0056379660  0.0057296013  5.816859e-03  5.899258e-03
## ASV1715      0.0171920723  0.0177564030  1.833345e-02  1.892323e-02
## ASV0603      0.0043929153  0.0046302884  4.880631e-03  5.144538e-03
## ASV0826      0.0271867352  0.0280589156  2.895216e-02  2.986678e-02
## ASV0034     -0.0071663429 -0.0073385396 -7.511503e-03 -7.685117e-03
## ASV0838     -0.0081585942 -0.0090093547 -9.920820e-03 -1.089609e-02
## ASV0614     -0.0073563863 -0.0075882011 -7.825354e-03 -8.067931e-03
## ASV0014     -0.0197331769 -0.0203418889 -2.096225e-02 -2.159418e-02
## ASV0585     -0.0053783779 -0.0057376750 -6.110274e-03 -6.496014e-03
## ASV0016     -0.0206620549 -0.0213017227 -2.195385e-02 -2.261837e-02
## ASV5394     -0.0168184396 -0.0173557337 -1.790135e-02 -1.845472e-02
## ASV0666      0.0269159498  0.0275717353  2.823340e-02  2.890080e-02
## ASV2085     -0.0051644250 -0.0057247446 -6.318775e-03 -6.947783e-03
## ASV0003     -0.0140595732 -0.0144959575 -1.494109e-02 -1.539495e-02
## ASV0346      0.0090075890  0.0093167698  9.631638e-03  9.951997e-03
## ASV0267      0.0019838775  0.0020612192  2.136396e-03  2.208733e-03
## ASV0353      0.0144932312  0.0150473671  1.561807e-02  1.620553e-02
## ASV2419      0.0283713016  0.0291730658  2.998370e-02  3.080241e-02
## ASV0447      0.0212572911  0.0220695952  2.290719e-02  2.377062e-02
## ASV0654      0.0243467493  0.0250826746  2.583139e-02  2.659275e-02
## ASV0151      0.0068546961  0.0071798798  7.516923e-03  7.865959e-03
## ASV0065     -0.0088790858 -0.0091389571 -9.403488e-03 -9.672687e-03
## ASV0527      0.0229636453  0.0236636477  2.437613e-02  2.510086e-02
## ASV4055     -0.0079457616 -0.0084102194 -8.902520e-03 -9.424245e-03
## ASV0166     -0.0092860389 -0.0095125443 -9.741659e-03 -9.973458e-03
## ASV0417     -0.0021966633 -0.0021916315 -2.183453e-03 -2.172117e-03
## ASV0078     -0.0052363363 -0.0053259709 -5.412009e-03 -5.494056e-03
## ASV0322      0.0033783006  0.0036826506  4.006223e-03  4.349743e-03
## ASV0156     -0.0200842513 -0.0208584105 -2.165895e-02 -2.248665e-02
## ASV0648     -0.0435296471 -0.0451267085 -4.676707e-02 -4.845083e-02
## ASV0407     -0.0042143092 -0.0044085922 -4.611173e-03 -4.822333e-03
## ASV2030     -0.0080606826 -0.0084560896 -8.870808e-03 -9.305522e-03
## ASV0300      0.0057786269  0.0059963345  6.219640e-03  6.448507e-03
## ASV1150      0.0017828408  0.0018485556  1.914798e-03  1.981389e-03
## ASV0958      0.0199255679  0.0207992128  2.170671e-02  2.264899e-02
## ASV0216     -0.0154304310 -0.0160211277 -1.663518e-02 -1.727356e-02
## ASV0446      0.0260295971  0.0269421346  2.787676e-02  2.883344e-02
## ASV0367     -0.0162115487 -0.0167741889 -1.735113e-02 -1.794244e-02
## ASV0200     -0.0091399652 -0.0094244153 -9.712931e-03 -1.000523e-02
## ASV0334     -0.0016543946 -0.0016692745 -1.686365e-03 -1.706088e-03
## ASV1311      0.0017341265  0.0016560981  1.568758e-03  1.471672e-03
## ASV0458      0.0027853100  0.0027177633  2.641467e-03  2.556129e-03
## ASV1371      0.0018008324  0.0018476167  1.893331e-03  1.937768e-03
## ASV0418      0.0149820351  0.0153433807  1.570779e-02  1.607518e-02
## ASV0004      0.0020104697  0.0020530388  2.095609e-03  2.138150e-03
## ASV1943      0.0213832482  0.0213873217  2.136989e-02  2.133075e-02
## ASV1495     -0.0126118767 -0.0133070186 -1.403367e-02 -1.479267e-02
## ASV0901     -0.0218108220 -0.0227210308 -2.366603e-02 -2.464692e-02
## ASV0628      0.0042419677  0.0042223863  4.193007e-03  4.153228e-03
## ASV0400      0.0034826632  0.0035037947  3.518032e-03  3.524754e-03
## ASV0116     -0.0061704380 -0.0064153780 -6.668674e-03 -6.930526e-03
## ASV0788      0.0560468049  0.0583445302  6.072756e-02  6.319865e-02
## ASV0117      0.0047014432  0.0048974705  5.100145e-03  5.309608e-03
## ASV3137     -0.0006769547 -0.0006785121 -6.779585e-04 -6.750504e-04
## ASV0001      0.0020367310  0.0020768242  2.117048e-03  2.157433e-03
## ASV1651      0.0065480204  0.0067115859  6.878102e-03  7.047753e-03
## ASV1692      0.0450809523  0.0468559178  4.869183e-02  5.059045e-02
## ASV0660      0.0045268190  0.0043885856  4.231492e-03  4.054773e-03
## ASV0508      0.0001432943  0.0001261646  1.066609e-04  8.457127e-05
## ASV1660     -0.0112655767 -0.0117111044 -1.216777e-02 -1.263536e-02
## ASV0233      0.0120173844  0.0124351604  1.286429e-02  1.330496e-02
## ASV1343     -0.0254955384 -0.0265056713 -2.755098e-02 -2.863243e-02
## ASV0209      0.0067017011  0.0068074797  6.909383e-03  7.007035e-03
## ASV0193     -0.0080501888 -0.0081725194 -8.289298e-03 -8.400037e-03
## ASV0357      0.0104480936  0.0110132082  1.160599e-02  1.222747e-02
## ASV0198      0.0085703523  0.0088525193  9.142776e-03  9.441344e-03
## ASV0007      0.0015118177  0.0015305905  1.548841e-03  1.566592e-03
## ASV1772      0.0018208369  0.0022025573  2.621856e-03  3.081495e-03
## ASV0009      0.0010130307  0.0010161829  1.018608e-03  1.020348e-03
## ASV0006     -0.0034857914 -0.0036275901 -3.773827e-03 -3.924546e-03
## ASV0011     -0.0099107964 -0.0102769579 -1.065396e-02 -1.104199e-02
## ASV0015      0.0006551109  0.0006456872  6.345008e-04  6.214720e-04
## ASV0017      0.0008481437  0.0008468761  8.442714e-04  8.402722e-04
## ASV0235     -0.0095062460 -0.0098738938 -1.025408e-02 -1.064718e-02
## ASV0382      0.0055960130  0.0056889963  5.774486e-03  5.851590e-03
## ASV2357      0.0302561113  0.0314011065  3.258133e-02  3.379726e-02
## ASV0567     -0.0071512816 -0.0074896794 -7.843932e-03 -8.214685e-03
## ASV0165      0.0047035048  0.0048625359  5.025220e-03  5.191568e-03
## ASV0005      0.0058282113  0.0059969681  6.168022e-03  6.341282e-03
## ASV0384      0.0022209982  0.0024029776  2.596469e-03  2.802017e-03
## ASV0002      0.0009787407  0.0010080287  1.037958e-03  1.068529e-03
## ASV3017      0.0235253058  0.0240114800  2.449550e-02  2.497692e-02
## ASV0091     -0.0011356746 -0.0012004361 -1.269564e-03 -1.343346e-03
## ASV0186     -0.0120104901 -0.0123530600 -1.269902e-02 -1.304807e-02
## ASV0370      0.0059040201  0.0060840829  6.268976e-03  6.458907e-03
## ASV0018      0.0077267372  0.0079616138  8.200573e-03  8.443553e-03
## ASV1377      0.0625403689  0.0640649854  6.560132e-02  6.714885e-02
## ASV0019      0.0082189394  0.0084738767  8.733657e-03  8.998247e-03
## ASV0023     -0.0061470378 -0.0063642774 -6.586546e-03 -6.813792e-03
## ASV2194      0.0117538207  0.0122601861  1.278584e-02  1.333129e-02
## ASV1155      0.0290529231  0.0299696747  3.091212e-02  3.188115e-02
## ASV0510     -0.0050303483 -0.0051329923 -5.238455e-03 -5.346950e-03
## ASV2371     -0.0164721554 -0.0169103412 -1.735333e-02 -1.780086e-02
## ASV0024     -0.0075646267 -0.0078319160 -8.105584e-03 -8.385598e-03
## ASV2452      0.0107097681  0.0107821572  1.084386e-02  1.089447e-02
## ASV2332     -0.0525028343 -0.0541542089 -5.584504e-02 -5.757583e-02
## ASV2591      0.0226832355  0.0235024986  2.433784e-02  2.518884e-02
## ASV0521      0.0158802630  0.0164836708  1.710596e-02  1.774751e-02
## ASV5542      0.0143046213  0.0148108308  1.533110e-02  1.586567e-02
## ASV0336     -0.0043678223 -0.0045973357 -4.837781e-03 -5.089666e-03
## ASV10102     0.0263821790  0.0272876755  2.821393e-02  2.916089e-02
## ASV16823    -0.0254816326 -0.0260859522 -2.669668e-02 -2.731375e-02
## ASV3104      0.1318393282  0.1349653167  1.381244e-01  1.413162e-01
## ASV0781      0.0264685437  0.0273810997  2.832059e-02  2.928769e-02
## ASV10899     0.0288109181  0.0301678286  3.157914e-02  3.304634e-02
## ASV11222    -0.0448451468 -0.0459081804 -4.698244e-02 -4.806784e-02
## ASV11327    -0.0402607622 -0.0412149519 -4.217921e-02 -4.315346e-02
## ASV12458    -0.0448402611 -0.0459028135 -4.697657e-02 -4.806144e-02
## ASV1636      0.0302855443  0.0311338411  3.199710e-02  3.287541e-02
## ASV1890     -0.0161359284 -0.0164418069 -1.675243e-02 -1.706837e-02
## ASV2898      0.0409717850  0.0421344067  4.331918e-02  4.452644e-02
## ASV8328      0.0263210133  0.0277864096  2.931592e-02  3.091102e-02
## ASV0709     -0.0488496183 -0.0502703539 -5.171499e-02 -5.318331e-02
## ASV0856      0.0567155164  0.0588666334  6.107854e-02  6.335164e-02
## ASV0909      0.0295166235  0.0309514738  3.244178e-02  3.398871e-02
## ASV0937     -0.0400610068 -0.0417304621 -4.346321e-02 -4.526104e-02
## ASV11390    -0.0639882654 -0.0655039230 -6.703554e-02 -6.858300e-02
## ASV11966     0.0299900389  0.0311404736  3.232197e-02  3.353455e-02
## ASV12990     0.0123537762  0.0126784609  1.300878e-02  1.334480e-02
## ASV14797     0.0175777297  0.0180246373  1.847872e-02  1.894010e-02
## ASV14904    -0.0918153683 -0.0939897081 -9.618694e-02 -9.840688e-02
## ASV15304     0.0218434364  0.0227288236  2.363937e-02  2.457511e-02
## ASV16696    -0.0317227226 -0.0324739227 -3.323304e-02 -3.400000e-02
## ASV1690      0.0905074775  0.0935914731  9.673669e-02  9.994195e-02
## ASV2029      0.0492190009  0.0507535995  5.232231e-02  5.392540e-02
## ASV2834      0.0713574424  0.0737365658  7.616708e-02  7.864872e-02
## ASV4003      0.0866369727  0.0907138736  9.497199e-02  9.941838e-02
## ASV4064      0.0356038274  0.0368739114  3.817966e-02  3.952176e-02
## ASV4294      0.0336677991  0.0352371657  3.686949e-02  3.856650e-02
## ASV4609      0.0171680000  0.0177600404  1.837035e-02  1.899932e-02
## ASV6283     -0.0296522884 -0.0303543898 -3.106389e-02 -3.178074e-02
## ASV6491     -0.0425000959 -0.0435064079 -4.452334e-02 -4.555081e-02
## ASV7453      0.0412175635  0.0428373153  4.450296e-02  4.621468e-02
## ASV7959      0.0229359226  0.0240655510  2.524296e-02  2.646966e-02
## ASV8219      0.3672859969  0.3759829803  3.847719e-01  3.936522e-01
## ASV8547     -0.0380495942 -0.0389506175 -3.986118e-02 -4.078122e-02
## ASV9319      0.0306346595  0.0318950778  3.320182e-02  3.455623e-02
## ASV9382     -0.0744489231 -0.0762120119 -7.799380e-02 -7.979416e-02
## ASV11516    -0.0497259883 -0.0509036892 -5.209390e-02 -5.329654e-02
## ASV14377    -0.0359050318 -0.0367554793 -3.761498e-02 -3.848346e-02
## ASV1867      0.0460036982  0.0477306450  4.951250e-02  5.135064e-02
## ASV1895      0.0091048054  0.0090565596  8.989700e-03  8.903459e-03
## ASV3168      0.0167636320  0.0170799070  1.739367e-02  1.770462e-02
## ASV4449      0.1427918262  0.1478669875  1.530959e-01  1.584824e-01
## ASV6596      0.0468203703  0.0489580289  5.117932e-02  5.348627e-02
## ASV7492      0.0082737267  0.0088904431  9.535910e-03  1.021062e-02
## ASV9854     -0.0072148540 -0.0073729128 -7.531803e-03 -7.691491e-03
## ASV6296      0.6025265274  0.6168021883  6.312305e-01  6.458106e-01
## ASV4201      0.0208475242  0.0220692963  2.335132e-02  2.469583e-02
## ASV0552      0.0299933490  0.0310104080  3.204934e-02  3.310983e-02
## ASV3671     -0.0207229745 -0.0216196036 -2.255682e-02 -2.353633e-02
## ASV3529      0.0037026211  0.0039607844  4.225843e-03  4.497477e-03
## ASV1060      0.0109852719  0.0115040391  1.204640e-02  1.261329e-02
## ASV0239     -0.0056725839 -0.0057513857 -5.827131e-03 -5.899566e-03
## ASV5711     -0.0403647319 -0.0416103207 -4.288201e-02 -4.417976e-02
## ASV4152     -0.0658575207 -0.0680502084 -7.029029e-02 -7.257733e-02
## ASV1461      0.0192633771  0.0195782875  1.988812e-02  2.019253e-02
## ASV2877      0.0103062117  0.0104520237  1.059081e-02  1.072197e-02
## ASV0012      0.0029551855  0.0030571979  3.161921e-03  3.269383e-03
## ASV9823     -0.0026974377 -0.0030286213 -3.381743e-03 -3.757621e-03
## ASV0008      0.0030639586  0.0031684931  3.275810e-03  3.385943e-03
## ASV7832     -0.0421197852 -0.0436670684 -4.525856e-02 -4.689480e-02
## ASV1915     -0.0052733710 -0.0055063010 -5.749484e-03 -6.003276e-03
## ASV0055     -0.0058385987 -0.0061123872 -6.397299e-03 -6.693667e-03
## ASV0032      0.0003522280  0.0003446717  3.374532e-04  3.307627e-04
## ASV2977     -0.0528839908 -0.0545786815 -5.630590e-02 -5.806512e-02
## ASV0466      0.0251261317  0.0254793467  2.581944e-02  2.614561e-02
## ASV3866      0.0359939655  0.0374511992  3.896113e-02  4.052526e-02
## ASV0040      0.0113077559  0.0117039967  1.211049e-02  1.252730e-02
## ASV0496     -0.0098826489 -0.0104025318 -1.094205e-02 -1.150137e-02
## ASV0052      0.0096510984  0.0100024738  1.036469e-02  1.073803e-02
## ASV3828     -0.0208848453 -0.0213599692 -2.183890e-02 -2.232154e-02
## ASV1930      0.0110744725  0.0112952069  1.151458e-02  1.173239e-02
## ASV2126      0.0249811112  0.0257890870  2.661785e-02  2.746778e-02
## ASV0793      0.0381617347  0.0395889266  4.106046e-02  4.257743e-02
## ASV0299     -0.0028906371 -0.0031198150 -3.365401e-03 -3.628279e-03
## ASV0208      0.0263968218  0.0273887776  2.841340e-02  2.947157e-02
## ASV0511     -0.0055314394 -0.0056393295 -5.749648e-03 -5.862660e-03
## ASV1123     -0.0180529902 -0.0183359998 -1.860875e-02 -1.887009e-02
## ASV0099      0.0024249284  0.0025658229  2.713812e-03  2.869130e-03
## ASV0752     -0.0225364249 -0.0234649247 -2.442647e-02 -2.542191e-02
## ASV0883      0.0289338438  0.0300088601  3.111135e-02  3.224119e-02
## ASV0683      0.0370355674  0.0384599243  3.992807e-02  4.144067e-02
## ASV4117     -0.0544543886 -0.0565111483 -5.863342e-02 -6.082260e-02
## ASV2172     -0.0007091711 -0.0008681258 -1.039364e-03 -1.223487e-03
## ASV0330     -0.0106153001 -0.0110328061 -1.146519e-02 -1.191291e-02
## ASV0728      0.0433611686  0.0447643550  4.620159e-02  4.767345e-02
## ASV0499      0.0150101801  0.0156076737  1.622473e-02  1.686172e-02
## ASV0120     -0.0189329753 -0.0194988724 -2.007276e-02 -2.065422e-02
## ASV1446      0.0019160389  0.0015636154  1.179005e-03  7.606881e-04
## ASV17171    -0.0409134657 -0.0424374555 -4.401089e-02 -4.563488e-02
## ASV0533      0.0044072545  0.0045952572  4.789430e-03  4.989836e-03
## ASV2495     -0.0183323432 -0.0192016697 -2.010279e-02 -2.103608e-02
## ASV5582      0.0063830613  0.0062737178  6.144464e-03  5.994094e-03
## ASV1488      0.0039809736  0.0039939330  3.998983e-03  3.995555e-03
## ASV0682      0.0110098437  0.0114364625  1.187545e-02  1.232688e-02
## ASV0068     -0.0146406221 -0.0150746173 -1.551360e-02 -1.595716e-02
## ASV1987     -0.0499366417 -0.0519488502 -5.402610e-02 -5.616944e-02
## ASV0035     -0.0095512255 -0.0101347672 -1.075011e-02 -1.139857e-02
## ASV7192     -0.0197569285 -0.0202882814 -2.082409e-02 -2.136387e-02
## ASV0873     -0.0692474564 -0.0729368942 -7.675529e-02 -8.070342e-02
## ASV4749     -0.0163106579 -0.0173034796 -1.834177e-02 -1.942668e-02
## ASV2174      0.0063677786  0.0062959147  6.209054e-03  6.106647e-03
## ASV1476     -0.0224854577 -0.0234289555 -2.440573e-02 -2.541652e-02
## ASV0740     -0.0609971537 -0.0635154772 -6.612562e-02 -6.883016e-02
## ASV0170     -0.0098353080 -0.0101893967 -1.055418e-02 -1.092989e-02
## ASV2466     -0.0462816369 -0.0479931518 -4.975672e-02 -5.157322e-02
## ASV1709      0.0171141310  0.0179275316  1.878652e-02  1.969376e-02
## ASV6170     -0.0784819069 -0.0814816961 -8.457319e-02 -8.775765e-02
## ASV3673      0.0408803873  0.0424887396  4.414709e-02  4.585603e-02
## ASV1745     -0.0129850620 -0.0135522229 -1.413957e-02 -1.474749e-02
##                                                                    
## (Intercept)  2.507137e-01  2.582800e-01  2.659779e-01  2.738053e-01
## ASV1236      3.975918e-02  4.080337e-02  4.186292e-02  4.293777e-02
## ASV0421      1.270951e-02  1.323257e-02  1.376839e-02  1.431681e-02
## ASV0691     -1.681104e-02 -1.695177e-02 -1.708567e-02 -1.721261e-02
## ASV0899      3.240729e-02  3.315423e-02  3.390797e-02  3.466858e-02
## ASV1004      7.853298e-02  8.051371e-02  8.251890e-02  8.454828e-02
## ASV1041     -2.614083e-02 -2.649070e-02 -2.682429e-02 -2.714070e-02
## ASV1058      4.979690e-02  5.111188e-02  5.244731e-02  5.380315e-02
## ASV12542     1.705954e-02  1.749799e-02  1.794606e-02  1.840403e-02
## ASV1294      4.734021e-02  4.864961e-02  4.998500e-02  5.134685e-02
## ASV13113     2.975364e-02  3.104265e-02  3.237992e-02  3.376664e-02
## ASV1318      4.577439e-02  4.696835e-02  4.818175e-02  4.941483e-02
## ASV2269     -7.311400e-02 -7.469414e-02 -7.627766e-02 -7.786393e-02
## ASV2542      5.947772e-02  6.172266e-02  6.403730e-02  6.642291e-02
## ASV2660     -2.892731e-02 -2.958957e-02 -3.025771e-02 -3.093170e-02
## ASV2737      8.352399e-03  8.548588e-03  8.749041e-03  8.953870e-03
## ASV2840      2.977454e-02  3.017793e-02  3.057120e-02  3.095403e-02
## ASV3053      1.923525e-01  1.969711e-01  2.016527e-01  2.063971e-01
## ASV3077      1.324271e-02  1.360681e-02  1.397879e-02  1.435876e-02
## ASV3134      4.348360e-02  4.529140e-02  4.716381e-02  4.910233e-02
## ASV3140      4.201673e-02  4.330963e-02  4.462703e-02  4.596876e-02
## ASV3579      2.466316e-02  2.568232e-02  2.673126e-02  2.780995e-02
## ASV6119     -2.000585e-02 -2.044102e-02 -2.087759e-02 -2.131535e-02
## ASV7557     -4.066007e-02 -4.154594e-02 -4.243478e-02 -4.332619e-02
## ASV8422      1.044702e-02  1.074165e-02  1.104386e-02  1.135391e-02
## ASV1086     -1.279826e-03 -1.327535e-03 -1.377623e-03 -1.430172e-03
## ASV1310      2.022626e-02  2.069857e-02  2.117357e-02  2.165098e-02
## ASV15750    -1.040257e-03 -1.002496e-03 -9.608136e-04 -9.150740e-04
## ASV16905    -8.366653e-03 -8.549936e-03 -8.733891e-03 -8.918413e-03
## ASV2033      5.934169e-02  6.146090e-02  6.363732e-02  6.587183e-02
## ASV2089      1.768060e-02  1.806638e-02  1.845333e-02  1.884119e-02
## ASV2127      6.171779e-02  6.331228e-02  6.493011e-02  6.657120e-02
## ASV2725      4.334006e-02  4.428041e-02  4.522631e-02  4.617755e-02
## ASV2804     -1.732897e-02 -1.770956e-02 -1.809153e-02 -1.847460e-02
## ASV3075      5.680470e-02  5.891746e-02  6.109984e-02  6.335344e-02
## ASV3327      8.134299e-02  8.415368e-02  8.703711e-02  8.999423e-02
## ASV3342      6.909898e-02  7.153522e-02  7.403986e-02  7.661394e-02
## ASV3532     -7.387436e-02 -7.656979e-02 -7.935561e-02 -8.223448e-02
## ASV3600      3.381264e-02  3.494873e-02  3.611253e-02  3.730422e-02
## ASV4013      5.169170e-02  5.310268e-02  5.453214e-02  5.597953e-02
## ASV4136      4.725287e-02  4.845463e-02  4.967471e-02  5.091308e-02
## ASV4195      1.770177e-01  1.809142e-01  1.848237e-01  1.887433e-01
## ASV4407     -6.840793e-02 -6.991413e-02 -7.142518e-02 -7.293988e-02
## ASV4717      8.977788e-03  9.182509e-03  9.393393e-03  9.610867e-03
## ASV6794      2.727220e-02  2.798218e-02  2.870725e-02  2.944780e-02
## ASV8324     -3.511719e-02 -3.589129e-02 -3.666777e-02 -3.744600e-02
## ASV8981      3.894202e-03  4.156170e-03  4.429917e-03  4.715670e-03
## ASV9859      3.414403e-02  3.585288e-02  3.763867e-02  3.950405e-02
## ASV0936      4.860559e-02  5.011193e-02  5.164553e-02  5.320601e-02
## ASV12683    -3.457944e-04 -3.266229e-04 -3.036447e-04 -2.765476e-04
## ASV1293      2.317792e-02  2.372661e-02  2.428058e-02  2.483972e-02
## ASV13055     2.757079e-03  2.940440e-03  3.132518e-03  3.333603e-03
## ASV17063    -1.823331e-02 -1.863481e-02 -1.903731e-02 -1.944048e-02
## ASV2228      1.487183e-02  1.519932e-02  1.552762e-02  1.585647e-02
## ASV2769      5.938607e-03  6.152475e-03  6.369370e-03  6.589078e-03
## ASV2803      1.327158e-02  1.354124e-02  1.381407e-02  1.409025e-02
## ASV2896      2.359205e-02  2.460652e-02  2.566286e-02  2.676264e-02
## ASV3062      3.164651e-02  3.288714e-02  3.416259e-02  3.547302e-02
## ASV3107      3.796658e-02  3.935046e-02  4.077450e-02  4.223927e-02
## ASV3265      3.233125e-02  3.306938e-02  3.381284e-02  3.456135e-02
## ASV3666     -6.536342e-04 -7.036695e-04 -7.557449e-04 -8.098364e-04
## ASV4497      1.249911e-02  1.283358e-02  1.317345e-02  1.351873e-02
## ASV6914     -4.540155e-03 -4.729190e-03 -4.923514e-03 -5.123110e-03
## ASV0576     -2.926253e-02 -2.971715e-02 -3.016696e-02 -3.061165e-02
## ASV0673      5.088503e-02  5.232711e-02  5.379737e-02  5.529622e-02
## ASV0772      2.654481e-02  2.741527e-02  2.830936e-02  2.922759e-02
## ASV0862      1.193099e-02  1.244507e-02  1.296996e-02  1.350526e-02
## ASV0898      2.596655e-02  2.687107e-02  2.779789e-02  2.874725e-02
## ASV0910      2.891920e-02  2.997037e-02  3.105170e-02  3.216362e-02
## ASV0964     -1.198848e-02 -1.220463e-02 -1.242120e-02 -1.263821e-02
## ASV10059     2.477207e-02  2.575290e-02  2.676381e-02  2.780514e-02
## ASV10263    -2.778537e-02 -2.839822e-02 -2.901273e-02 -2.962855e-02
## ASV1088      5.190274e-02  5.389988e-02  5.596450e-02  5.809823e-02
## ASV1101      3.949940e-02  4.040130e-02  4.131040e-02  4.222654e-02
## ASV1183      1.498815e-02  1.550503e-02  1.603711e-02  1.658481e-02
## ASV11956     8.137581e-03  8.320957e-03  8.508707e-03  8.701024e-03
## ASV12774    -2.827661e-03 -2.996254e-03 -3.171090e-03 -3.352231e-03
## ASV1321      7.680572e-02  7.954703e-02  8.235744e-02  8.523702e-02
## ASV13793    -1.916237e-02 -1.958533e-02 -2.000961e-02 -2.043502e-02
## ASV14482     1.325216e-03  1.389107e-03  1.456494e-03  1.527481e-03
## ASV15483     1.179873e-02  1.219410e-02  1.259932e-02  1.301453e-02
## ASV2062      4.558514e-02  4.696043e-02  4.836514e-02  4.979942e-02
## ASV2132      4.451414e-02  4.598543e-02  4.748927e-02  4.902559e-02
## ASV2413      3.225364e-02  3.317643e-02  3.411936e-02  3.508281e-02
## ASV2490      7.982952e-02  8.153629e-02  8.325411e-02  8.498268e-02
## ASV2594      1.810881e-02  1.884541e-02  1.960996e-02  2.040330e-02
## ASV2822     -5.056982e-02 -5.168817e-02 -5.281067e-02 -5.393694e-02
## ASV2863      5.493308e-02  5.630978e-02  5.770594e-02  5.912160e-02
## ASV2910      2.066576e-02  2.119843e-02  2.173996e-02  2.229050e-02
## ASV2980      2.675963e-02  2.753036e-02  2.831542e-02  2.911488e-02
## ASV3307      4.025561e-02  4.114817e-02  4.204465e-02  4.294481e-02
## ASV3474      4.657739e-02  4.830449e-02  5.007884e-02  5.190073e-02
## ASV3502      3.882938e-02  4.014159e-02  4.149112e-02  4.287884e-02
## ASV4236      3.465129e-02  3.529290e-02  3.593430e-02  3.657532e-02
## ASV4842     -3.767993e-03 -3.758540e-03 -3.741188e-03 -3.715686e-03
## ASV4894     -1.917969e-02 -1.960613e-02 -2.003466e-02 -2.046520e-02
## ASV5290      2.194875e-02  2.268253e-02  2.343606e-02  2.420979e-02
## ASV5501      1.580369e-02  1.648270e-02  1.719001e-02  1.792657e-02
## ASV5795      1.516870e-02  1.566612e-02  1.617403e-02  1.669234e-02
## ASV5987     -5.358940e-02 -5.478468e-02 -5.598648e-02 -5.719457e-02
## ASV6267     -6.039921e-02 -6.174828e-02 -6.310502e-02 -6.446918e-02
## ASV6862      2.343298e-02  2.400522e-02  2.458601e-02  2.517542e-02
## ASV7145      1.148339e-02  1.185041e-02  1.222843e-02  1.261768e-02
## ASV7673     -1.919863e-02 -1.962849e-02 -2.006093e-02 -2.049588e-02
## ASV7789      2.366578e-02  2.473761e-02  2.584969e-02  2.700292e-02
## ASV7809      4.802983e-03  5.031844e-03  5.267332e-03  5.509384e-03
## ASV8002     -2.426327e-02 -2.480878e-02 -2.535785e-02 -2.591041e-02
## ASV8205      1.504709e-02  1.556308e-02  1.609174e-02  1.663307e-02
## ASV9155     -4.758805e-03 -4.816013e-03 -4.870819e-03 -4.923140e-03
## ASV9221      1.161383e-02  1.222090e-02  1.285387e-02  1.351351e-02
## ASV9311     -3.896555e-02 -3.984670e-02 -4.073416e-02 -4.162774e-02
## ASV9557     -2.664065e-02 -2.724411e-02 -2.785196e-02 -2.846408e-02
## ASV9936     -5.374657e-02 -5.496604e-02 -5.619454e-02 -5.743180e-02
## ASV1445      4.666030e-02  4.818500e-02  4.974361e-02  5.133609e-02
## ASV4232      2.764687e-02  2.896274e-02  3.033741e-02  3.177298e-02
## ASV6479      1.765409e-02  1.856877e-02  1.952226e-02  2.051560e-02
## ASV0142     -2.339893e-02 -2.397387e-02 -2.455648e-02 -2.514677e-02
## ASV0378      1.894567e-02  1.961345e-02  2.029474e-02  2.098921e-02
## ASV1122      4.811027e-02  4.979266e-02  5.152032e-02  5.329380e-02
## ASV0123     -2.025534e-02 -2.073523e-02 -2.122024e-02 -2.171031e-02
## ASV2064      4.777123e-03  4.658952e-03  4.524766e-03  4.373955e-03
## ASV4459     -9.720149e-04 -1.036968e-03 -1.108577e-03 -1.187261e-03
## ASV0448      1.575550e-02  1.635562e-02  1.697219e-02  1.760520e-02
## ASV0397      2.347741e-02  2.417346e-02  2.488301e-02  2.560611e-02
## ASV0485      2.562620e-02  2.636385e-02  2.711547e-02  2.788107e-02
## ASV1566      3.971332e-02  4.088070e-02  4.206971e-02  4.328027e-02
## ASV1365      3.495023e-02  3.593864e-02  3.694098e-02  3.795710e-02
## ASV1065      5.191449e-02  5.353443e-02  5.518800e-02  5.687522e-02
## ASV0722     -4.614416e-03 -4.845257e-03 -5.087009e-03 -5.340087e-03
## ASV12660    -2.131192e-02 -2.179720e-02 -2.228683e-02 -2.278071e-02
## ASV0223      7.734093e-03  7.991087e-03  8.255501e-03  8.527483e-03
## ASV0229      1.456512e-02  1.511436e-02  1.568195e-02  1.626843e-02
## ASV0877     -2.238336e-03 -2.626710e-03 -3.045483e-03 -3.496125e-03
## ASV0983      2.329625e-02  2.387884e-02  2.446708e-02  2.506070e-02
## ASV0626      9.084154e-03  9.482801e-03  9.893282e-03  1.031571e-02
## ASV4146     -2.911861e-03 -3.247518e-03 -3.608484e-03 -3.995830e-03
## ASV4175     -3.826105e-02 -3.950223e-02 -4.076952e-02 -4.206274e-02
## ASV2082     -3.657437e-02 -3.835568e-02 -4.020690e-02 -4.212942e-02
## ASV2272      1.925120e-02  1.995238e-02  2.067486e-02  2.141907e-02
## ASV2245     -2.813396e-02 -2.905919e-02 -3.000404e-02 -3.096836e-02
## ASV0590     -3.774918e-02 -3.960842e-02 -4.154218e-02 -4.355221e-02
## ASV0217      1.128711e-02  1.187808e-02  1.249202e-02  1.312946e-02
## ASV0416      6.291800e-03  6.161087e-03  6.013734e-03  5.849265e-03
## ASV1056      2.950712e-02  3.052106e-02  3.155782e-02  3.261730e-02
## ASV7777     -3.935622e-02 -4.085880e-02 -4.241799e-02 -4.403618e-02
## ASV0455      5.631530e-03  5.770879e-03  5.909965e-03  6.048520e-03
## ASV0604      2.110930e-02  2.189088e-02  2.269404e-02  2.351897e-02
## ASV6100     -2.982006e-02 -3.101554e-02 -3.225611e-02 -3.354334e-02
## ASV11359    -5.197016e-02 -5.353063e-02 -5.511562e-02 -5.672445e-02
## ASV6604      8.820109e-03  9.112545e-03  9.408936e-03  9.708870e-03
## ASV5004     -1.940103e-02 -2.008606e-02 -2.079207e-02 -2.151949e-02
## ASV1483     -7.290779e-03 -7.493540e-03 -7.698299e-03 -7.904824e-03
## ASV9773     -2.665429e-02 -2.763697e-02 -2.865102e-02 -2.969722e-02
## ASV4059      7.837974e-03  8.235304e-03  8.642304e-03  9.058414e-03
## ASV1193      2.705710e-02  2.789569e-02  2.875214e-02  2.962646e-02
## ASV4610      3.321641e-03  3.511900e-03  3.703470e-03  3.895833e-03
## ASV0742      4.813067e-03  5.084215e-03  5.362010e-03  5.646223e-03
## ASV1502     -6.478396e-03 -6.775780e-03 -7.080727e-03 -7.393043e-03
## ASV0195     -2.437738e-03 -2.583222e-03 -2.734515e-03 -2.891743e-03
## ASV1213      1.087092e-02  1.100767e-02  1.113926e-02  1.126540e-02
## ASV1648     -2.714231e-02 -2.825353e-02 -2.940753e-02 -3.060569e-02
## ASV6984     -2.597828e-02 -2.706011e-02 -2.818436e-02 -2.935240e-02
## ASV0396      5.392814e-04  4.987968e-04  4.473909e-04  3.839624e-04
## ASV4297      1.870113e-02  1.908863e-02  1.947995e-02  1.987533e-02
## ASV2622      3.577570e-02  3.672348e-02  3.768643e-02  3.866460e-02
## ASV3512      3.325973e-02  3.486136e-02  3.653154e-02  3.827249e-02
## ASV2411      3.863864e-02  4.004869e-02  4.149387e-02  4.297392e-02
## ASV2291     -3.226305e-02 -3.376737e-02 -3.532444e-02 -3.693505e-02
## ASV0807      3.813156e-02  3.922412e-02  4.033590e-02  4.146708e-02
## ASV1292      4.609424e-03  4.680521e-03  4.754941e-03  4.833200e-03
## ASV1035      3.031449e-02  3.116888e-02  3.204259e-02  3.293610e-02
## ASV0070      4.770254e-03  5.045718e-03  5.333115e-03  5.632708e-03
## ASV0255     -2.706647e-04 -4.393595e-04 -6.228053e-04 -8.217578e-04
## ASV0057     -5.166420e-03 -5.192662e-03 -5.213465e-03 -5.228622e-03
## ASV0077     -9.082322e-05 -7.133772e-05 -5.347128e-05 -3.763840e-05
## ASV0625      1.473628e-02  1.504069e-02  1.534614e-02  1.565257e-02
## ASV2464      1.036435e-01  1.059959e-01  1.083687e-01  1.107613e-01
## ASV1315      5.188234e-02  5.382288e-02  5.581575e-02  5.786102e-02
## ASV2673      4.538516e-02  4.713499e-02  4.893739e-02  5.079301e-02
## ASV2161      1.987681e-02  2.069475e-02  2.154147e-02  2.241759e-02
## ASV0337     -9.200976e-03 -9.527264e-03 -9.862918e-03 -1.020809e-02
## ASV7680     -6.175850e-02 -6.393077e-02 -6.615881e-02 -6.844275e-02
## ASV0611      3.592999e-02  3.728154e-02  3.867619e-02  4.011492e-02
## ASV3118     -4.237030e-02 -4.399613e-02 -4.566922e-02 -4.739005e-02
## ASV1284     -1.909548e-02 -2.065795e-02 -2.231055e-02 -2.405679e-02
## ASV0889      2.070691e-02  2.139528e-02  2.210633e-02  2.284099e-02
## ASV4649     -1.207677e-02 -1.249310e-02 -1.292092e-02 -1.336041e-02
## ASV1108     -3.563104e-02 -3.710496e-02 -3.862704e-02 -4.019799e-02
## ASV0738      2.717383e-02  2.849852e-02  2.988016e-02  3.132067e-02
## ASV0473     -4.938936e-03 -5.055074e-03 -5.163994e-03 -5.264534e-03
## ASV0598     -1.687354e-02 -1.773832e-02 -1.863997e-02 -1.957942e-02
## ASV0429      1.091760e-02  1.109643e-02  1.127186e-02  1.144374e-02
## ASV1549      4.201348e-02  4.359808e-02  4.522453e-02  4.689263e-02
## ASV1203      2.078397e-02  2.132682e-02  2.187550e-02  2.242976e-02
## ASV4532      6.260501e-04  6.913963e-04  7.641657e-04  8.449429e-04
## ASV0274      5.647372e-03  5.798906e-03  5.948192e-03  6.094650e-03
## ASV0163     -1.387018e-02 -1.424875e-02 -1.463739e-02 -1.503655e-02
## ASV1298      2.804652e-03  3.024110e-03  3.261236e-03  3.517075e-03
## ASV9424     -5.253624e-02 -5.461322e-02 -5.676258e-02 -5.898620e-02
## ASV0412      3.528981e-02  3.623660e-02  3.719835e-02  3.817511e-02
## ASV0284      4.335919e-04  1.820472e-04 -9.085219e-05 -3.861657e-04
## ASV0620     -1.736886e-02 -1.814918e-02 -1.895752e-02 -1.979445e-02
## ASV0153     -5.467659e-02 -5.668826e-02 -5.875146e-02 -6.086612e-02
## ASV0498      1.455447e-02  1.492528e-02  1.529516e-02  1.566343e-02
## ASV0097      1.104179e-02  1.145777e-02  1.188465e-02  1.232235e-02
## ASV0104     -5.128009e-02 -5.266917e-02 -5.407559e-02 -5.549882e-02
## ASV1282      1.021502e-02  1.018257e-02  1.012748e-02  1.004845e-02
## ASV3883     -2.440340e-02 -2.531819e-02 -2.625302e-02 -2.720733e-02
## ASV0801      9.898713e-03  1.032027e-02  1.076041e-02  1.121992e-02
## ASV1611     -4.808289e-02 -4.991551e-02 -5.180271e-02 -5.374516e-02
## ASV0227     -1.512091e-02 -1.582544e-02 -1.655663e-02 -1.731515e-02
## ASV0833      1.347141e-02  1.391082e-02  1.436031e-02  1.481997e-02
## ASV0718      6.093613e-02  6.297207e-02  6.505638e-02  6.718924e-02
## ASV1139     -3.849110e-03 -4.275355e-03 -4.724421e-03 -5.196776e-03
## ASV0766     -1.228519e-02 -1.275328e-02 -1.323268e-02 -1.372323e-02
## ASV2091      2.988724e-02  3.042929e-02  3.096687e-02  3.149958e-02
## ASV1238     -5.794029e-02 -6.046432e-02 -6.309291e-02 -6.582968e-02
## ASV9193     -1.624964e-02 -1.715896e-02 -1.810995e-02 -1.910376e-02
## ASV0290      2.307850e-03  2.378881e-03  2.456769e-03  2.542047e-03
## ASV0231      1.281166e-02  1.307474e-02  1.333448e-02  1.359034e-02
## ASV0185      2.033649e-02  2.130676e-02  2.231643e-02  2.336659e-02
## ASV2330      1.162112e-02  1.185578e-02  1.209386e-02  1.233560e-02
## ASV3119     -1.743970e-02 -1.824747e-02 -1.908650e-02 -1.995752e-02
## ASV2368     -3.349671e-02 -3.500576e-02 -3.657624e-02 -3.820996e-02
## ASV0122     -9.267647e-03 -9.536758e-03 -9.811389e-03 -1.009164e-02
## ASV1044      3.521678e-02  3.660856e-02  3.804726e-02  3.953399e-02
## ASV0160     -7.431613e-03 -7.624891e-03 -7.824525e-03 -8.030935e-03
## ASV0326      2.533469e-03  2.574922e-03  2.613734e-03  2.649621e-03
## ASV1388      4.776216e-02  4.907422e-02  5.040533e-02  5.175525e-02
## ASV0792      2.957213e-02  3.023576e-02  3.090304e-02  3.157375e-02
## ASV0036     -1.578282e-02 -1.632232e-02 -1.687185e-02 -1.743105e-02
## ASV2125      3.564731e-02  3.664257e-02  3.765059e-02  3.867087e-02
## ASV1075     -1.463769e-03 -1.561912e-03 -1.666149e-03 -1.776742e-03
## ASV0390      3.036671e-02  3.167393e-02  3.303114e-02  3.443972e-02
## ASV3790     -3.403542e-02 -3.525850e-02 -3.651627e-02 -3.780920e-02
## ASV1535     -1.524859e-02 -1.588893e-02 -1.654829e-02 -1.722673e-02
## ASV0263      3.713052e-02  3.833161e-02  3.955957e-02  4.081446e-02
## ASV0675      6.596418e-02  6.838301e-02  7.087010e-02  7.342618e-02
## ASV3348      6.609314e-03  6.857995e-03  7.112219e-03  7.371816e-03
## ASV0058     -1.366762e-02 -1.402359e-02 -1.438335e-02 -1.474674e-02
## ASV4142      1.611871e-02  1.649907e-02  1.688516e-02  1.727717e-02
## ASV0059     -1.036564e-02 -1.061842e-02 -1.087333e-02 -1.113029e-02
## ASV0013     -2.298452e-02 -2.370970e-02 -2.445090e-02 -2.520824e-02
## ASV0033     -1.369363e-02 -1.417146e-02 -1.465948e-02 -1.515750e-02
## ASV4354     -1.544517e-02 -1.600788e-02 -1.658605e-02 -1.717973e-02
## ASV0022     -1.172393e-02 -1.214308e-02 -1.257187e-02 -1.301016e-02
## ASV0134     -1.488488e-02 -1.558029e-02 -1.630648e-02 -1.706469e-02
## ASV0415      2.697834e-03  2.794546e-03  2.893148e-03  2.993636e-03
## ASV10103    -6.278100e-02 -6.507624e-02 -6.743364e-02 -6.985351e-02
## ASV1613      2.629404e-02  2.675195e-02  2.719998e-02  2.763726e-02
## ASV0135     -2.329546e-03 -2.336827e-03 -2.341363e-03 -2.343047e-03
## ASV0469     -4.455372e-02 -4.593170e-02 -4.734378e-02 -4.879062e-02
## ASV0471      3.059286e-02  3.164036e-02  3.272019e-02  3.383338e-02
## ASV0451     -1.196290e-02 -1.250261e-02 -1.305942e-02 -1.363341e-02
## ASV0747      1.760310e-02  1.813492e-02  1.867457e-02  1.922176e-02
## ASV1314     -2.565420e-02 -2.675921e-02 -2.790569e-02 -2.909469e-02
## ASV0425     -4.400623e-02 -4.503165e-02 -4.606792e-02 -4.711500e-02
## ASV0559     -1.775155e-02 -1.848911e-02 -1.925614e-02 -2.005348e-02
## ASV0148      2.629580e-03  2.905373e-03  3.198223e-03  3.508817e-03
## ASV0129      1.503631e-02  1.586717e-02  1.673490e-02  1.764046e-02
## ASV1072     -3.613868e-05 -1.590352e-04 -2.901913e-04 -4.297672e-04
## ASV2390      1.522391e-02  1.525763e-02  1.527217e-02  1.526690e-02
## ASV0548      1.931535e-02  1.987821e-02  2.045089e-02  2.103334e-02
## ASV0168     -9.041886e-03 -9.297937e-03 -9.558975e-03 -9.825057e-03
## ASV0066     -9.699240e-03 -9.914652e-03 -1.012848e-02 -1.034030e-02
## ASV0468     -7.228687e-03 -7.505059e-03 -7.791384e-03 -8.087989e-03
## ASV0172     -4.906825e-05  5.580382e-05  1.685861e-04  2.895734e-04
## ASV0236      1.201593e-02  1.272643e-02  1.346627e-02  1.423592e-02
## ASV0250      3.070296e-02  3.213528e-02  3.362603e-02  3.517690e-02
## ASV0338      8.646569e-03  8.877825e-03  9.108818e-03  9.339096e-03
## ASV0450     -4.617647e-03 -4.859259e-03 -5.110961e-03 -5.372940e-03
## ASV0377      1.210658e-02  1.237695e-02  1.264527e-02  1.291099e-02
## ASV1022      1.181648e-03  1.313731e-03  1.456181e-03  1.609586e-03
## ASV6174     -1.844681e-03 -1.903159e-03 -1.957488e-03 -2.006793e-03
## ASV0786     -5.910466e-03 -6.144529e-03 -6.381780e-03 -6.621776e-03
## ASV0053     -1.653237e-02 -1.705578e-02 -1.759023e-02 -1.813575e-02
## ASV0697     -8.126644e-03 -8.378210e-03 -8.638419e-03 -8.907802e-03
## ASV0785      1.797069e-02  1.848390e-02  1.900815e-02  1.954381e-02
## ASV1967     -1.789406e-02 -1.840786e-02 -1.893035e-02 -1.946140e-02
## ASV0385      8.325034e-03  8.565083e-03  8.805035e-03  9.044345e-03
## ASV0295      5.732971e-03  6.053856e-03  6.389298e-03  6.739719e-03
## ASV0072     -1.116804e-02 -1.135711e-02 -1.154109e-02 -1.171952e-02
## ASV0157      5.210643e-03  5.618760e-03  6.050068e-03  6.505433e-03
## ASV0501      3.544271e-02  3.649179e-02  3.755515e-02  3.863223e-02
## ASV10729    -4.985729e-02 -5.160070e-02 -5.338976e-02 -5.522490e-02
## ASV1470      1.047487e-02  1.045514e-02  1.041587e-02  1.035602e-02
## ASV0050     -3.257410e-02 -3.343310e-02 -3.430156e-02 -3.517910e-02
## ASV0411     -1.157554e-02 -1.206084e-02 -1.256567e-02 -1.309078e-02
## ASV0549      1.613237e-02  1.669535e-02  1.727194e-02  1.786211e-02
## ASV0184      5.160552e-03  5.375994e-03  5.601216e-03  5.836706e-03
## ASV0705      5.976296e-03  6.047451e-03  6.112178e-03  6.169916e-03
## ASV1715      1.952578e-02  2.014112e-02  2.076925e-02  2.141018e-02
## ASV0603      5.422616e-03  5.715477e-03  6.023742e-03  6.348034e-03
## ASV0826      3.080312e-02  3.176151e-02  3.274227e-02  3.374576e-02
## ASV0034     -7.859266e-03 -8.033839e-03 -8.208726e-03 -8.383823e-03
## ASV0838     -1.193836e-02 -1.305086e-02 -1.423692e-02 -1.549990e-02
## ASV0614     -8.316023e-03 -8.569725e-03 -8.829139e-03 -9.094372e-03
## ASV0014     -2.223759e-02 -2.289236e-02 -2.355839e-02 -2.423556e-02
## ASV0585     -6.894684e-03 -7.306025e-03 -7.729731e-03 -8.165446e-03
## ASV0016     -2.329521e-02 -2.398428e-02 -2.468550e-02 -2.539875e-02
## ASV5394     -1.901520e-02 -1.958207e-02 -2.015455e-02 -2.073178e-02
## ASV0666      2.957380e-02  3.025229e-02  3.093618e-02  3.162537e-02
## ASV2085     -7.613063e-03 -8.315932e-03 -9.057737e-03 -9.839849e-03
## ASV0003     -1.585753e-02 -1.632881e-02 -1.680876e-02 -1.729735e-02
## ASV0346      1.027763e-02  1.060832e-02  1.094381e-02  1.128387e-02
## ASV0267      2.277501e-03  2.341913e-03  2.401128e-03  2.454244e-03
## ASV0353      1.680993e-02  1.743142e-02  1.807015e-02  1.872622e-02
## ASV2419      3.162838e-02  3.246069e-02  3.329838e-02  3.414043e-02
## ASV0447      2.466041e-02  2.557711e-02  2.652128e-02  2.749347e-02
## ASV0654      2.736661e-02  2.815280e-02  2.895118e-02  2.976158e-02
## ASV0151      8.227098e-03  8.600436e-03  8.986045e-03  9.383980e-03
## ASV0065     -9.946565e-03 -1.022514e-02 -1.050842e-02 -1.079644e-02
## ASV0527      2.583759e-02  2.658603e-02  2.734586e-02  2.811673e-02
## ASV4055     -9.977046e-03 -1.056265e-02 -1.118287e-02 -1.183959e-02
## ASV0166     -1.020803e-02 -1.044550e-02 -1.068598e-02 -1.092963e-02
## ASV0417     -2.157633e-03 -2.140036e-03 -2.119385e-03 -2.095767e-03
## ASV0078     -5.571702e-03 -5.644524e-03 -5.712084e-03 -5.773932e-03
## ASV0322      4.713933e-03  5.099507e-03  5.507178e-03  5.937646e-03
## ASV0156     -2.334231e-02 -2.422673e-02 -2.514076e-02 -2.608527e-02
## ASV0648     -5.017800e-02 -5.194850e-02 -5.376217e-02 -5.561875e-02
## ASV0407     -5.042360e-03 -5.271541e-03 -5.510169e-03 -5.758540e-03
## ASV2030     -9.760910e-03 -1.023764e-02 -1.073637e-02 -1.125775e-02
## ASV0300      6.682889e-03  6.922724e-03  7.167939e-03  7.418449e-03
## ASV1150      2.048132e-03  2.114817e-03  2.181217e-03  2.247089e-03
## ASV0958      2.362701e-02  2.464172e-02  2.569405e-02  2.678495e-02
## ASV0216     -1.793724e-02 -1.862723e-02 -1.934456e-02 -2.009028e-02
## ASV0446      2.981210e-02  3.081267e-02  3.183502e-02  3.287899e-02
## ASV0367     -1.854818e-02 -1.916838e-02 -1.980305e-02 -2.045220e-02
## ASV0200     -1.030101e-02 -1.059992e-02 -1.090161e-02 -1.120568e-02
## ASV0334     -1.728899e-03 -1.755281e-03 -1.785753e-03 -1.820864e-03
## ASV1311      1.364403e-03  1.246504e-03  1.117524e-03  9.770038e-04
## ASV0458      2.461465e-03  2.357196e-03  2.243055e-03  2.118783e-03
## ASV1371      1.980714e-03  2.021949e-03  2.061248e-03  2.098384e-03
## ASV0418      1.644546e-02  1.681858e-02  1.719449e-02  1.757316e-02
## ASV0004      2.180632e-03  2.223028e-03  2.265306e-03  2.307438e-03
## ASV1943      2.126978e-02  2.118686e-02  2.108194e-02  2.095499e-02
## ASV1495     -1.558484e-02 -1.641097e-02 -1.727182e-02 -1.816814e-02
## ASV0901     -2.566482e-02 -2.672089e-02 -2.781627e-02 -2.895212e-02
## ASV0628      4.102425e-03  4.039955e-03  3.965154e-03  3.877337e-03
## ASV0400      3.523312e-03  3.513029e-03  3.493198e-03  3.463088e-03
## ASV0116     -7.201136e-03 -7.480704e-03 -7.769432e-03 -8.067517e-03
## ASV0788      6.576064e-02  6.841647e-02  7.116915e-02  7.402181e-02
## ASV0117      5.526003e-03  5.749479e-03  5.980187e-03  6.218285e-03
## ASV3137     -6.695261e-04 -6.611057e-04 -6.494898e-04 -6.343597e-04
## ASV0001      2.198013e-03  2.238832e-03  2.279939e-03  2.321392e-03
## ASV1651      7.220744e-03  7.397307e-03  7.577698e-03  7.762202e-03
## ASV1692      5.255357e-02  5.458307e-02  5.668085e-02  5.884891e-02
## ASV0660      3.857675e-03  3.639464e-03  3.399427e-03  3.136873e-03
## ASV0508      5.966907e-05  3.171246e-05  4.438590e-07 -3.441049e-05
## ASV1660     -1.311359e-02 -1.360216e-02 -1.410072e-02 -1.460887e-02
## ASV0233      1.375737e-02  1.422174e-02  1.469828e-02  1.518720e-02
## ASV1343     -2.975098e-02 -3.090763e-02 -3.210338e-02 -3.333922e-02
## ASV0209      7.100051e-03  7.188032e-03  7.270571e-03  7.347253e-03
## ASV0193     -8.504239e-03 -8.601399e-03 -8.691005e-03 -8.772541e-03
## ASV0357      1.287866e-02  1.356060e-02  1.427433e-02  1.502088e-02
## ASV0198      9.748448e-03  1.006432e-02  1.038918e-02  1.072328e-02
## ASV0007      1.583876e-03  1.600729e-03  1.617198e-03  1.633335e-03
## ASV1772      3.584383e-03  4.133586e-03  4.732322e-03  5.383974e-03
## ASV0009      1.021456e-03  1.021991e-03  1.022025e-03  1.021638e-03
## ASV0006     -4.079788e-03 -4.239586e-03 -4.403973e-03 -4.572971e-03
## ASV0011     -1.144122e-02 -1.185182e-02 -1.227396e-02 -1.270780e-02
## ASV0015      6.065202e-04  5.895634e-04  5.705182e-04  5.493000e-04
## ASV0017      8.348202e-04  8.278565e-04  8.193215e-04  8.091549e-04
## ASV0235     -1.105358e-02 -1.147366e-02 -1.190784e-02 -1.235651e-02
## ASV0382      5.919377e-03  5.976878e-03  6.023084e-03  6.056952e-03
## ASV2357      3.504935e-02  3.633798e-02  3.766350e-02  3.902617e-02
## ASV0567     -8.602596e-03 -9.008335e-03 -9.432582e-03 -9.876025e-03
## ASV0165      5.361592e-03  5.535304e-03  5.712718e-03  5.893850e-03
## ASV0005      6.516650e-03  6.694026e-03  6.873303e-03  7.054373e-03
## ASV0384      3.020184e-03  3.251548e-03  3.496700e-03  3.756247e-03
## ASV0002      1.099742e-03  1.131594e-03  1.164081e-03  1.197198e-03
## ASV3017      2.545528e-02  2.593014e-02  2.640109e-02  2.686772e-02
## ASV0091     -1.422082e-03 -1.506085e-03 -1.595682e-03 -1.691209e-03
## ASV0186     -1.339986e-02 -1.375408e-02 -1.411038e-02 -1.446840e-02
## ASV0370      6.654099e-03  6.854792e-03  7.061242e-03  7.273720e-03
## ASV0018      8.690489e-03  8.941309e-03  9.195942e-03  9.454310e-03
## ASV1377      6.870706e-02  7.027550e-02  7.185376e-02  7.344148e-02
## ASV0019      9.267607e-03  9.541696e-03  9.820471e-03  1.010388e-02
## ASV0023     -7.045956e-03 -7.282968e-03 -7.524748e-03 -7.771206e-03
## ASV2194      1.389706e-02  1.448366e-02  1.509160e-02  1.572137e-02
## ASV1155      3.287772e-02  3.390283e-02  3.495752e-02  3.604291e-02
## ASV0510     -5.458686e-03 -5.573866e-03 -5.692681e-03 -5.815312e-03
## ASV2371     -1.825270e-02 -1.870858e-02 -1.916825e-02 -1.963145e-02
## ASV0024     -8.671912e-03 -8.964473e-03 -9.263214e-03 -9.568063e-03
## ASV2452      1.093364e-02  1.096099e-02  1.097621e-02  1.097896e-02
## ASV2332     -5.934703e-02 -6.115913e-02 -6.301253e-02 -6.490767e-02
## ASV2591      2.605506e-02  2.693602e-02  2.783121e-02  2.874012e-02
## ASV0521      1.840869e-02  1.908990e-02  1.979150e-02  2.051386e-02
## ASV5542      1.641475e-02  1.697858e-02  1.755737e-02  1.815134e-02
## ASV0336     -5.353525e-03 -5.629925e-03 -5.919465e-03 -6.222777e-03
## ASV10102     3.012848e-02  3.111660e-02  3.212516e-02  3.315401e-02
## ASV16823    -2.793712e-02 -2.856675e-02 -2.920263e-02 -2.984473e-02
## ASV3104      1.445406e-01  1.477974e-01  1.510864e-01  1.544076e-01
## ASV0781      3.028308e-02  3.130744e-02  3.236145e-02  3.344581e-02
## ASV10899     3.457089e-02  3.615429e-02  3.779800e-02  3.950350e-02
## ASV11222    -4.916429e-02 -5.027172e-02 -5.139011e-02 -5.251942e-02
## ASV11327    -4.413761e-02 -4.513163e-02 -4.613546e-02 -4.714910e-02
## ASV12458    -4.915734e-02 -5.026422e-02 -5.138203e-02 -5.251074e-02
## ASV1636      3.376887e-02  3.467758e-02  3.560166e-02  3.654125e-02
## ASV1890     -1.739022e-02 -1.771866e-02 -1.805439e-02 -1.839816e-02
## ASV2898      4.575655e-02  4.700990e-02  4.828691e-02  4.958803e-02
## ASV8328      3.257312e-02  3.430356e-02  3.610360e-02  3.797443e-02
## ASV0709     -5.467507e-02 -5.619001e-02 -5.772788e-02 -5.928836e-02
## ASV0856      6.568625e-02  6.808262e-02  7.054094e-02  7.306129e-02
## ASV0909      3.559339e-02  3.725694e-02  3.898044e-02  4.076496e-02
## ASV0937     -4.712574e-02 -4.905907e-02 -5.106278e-02 -5.313856e-02
## ASV11390    -7.014619e-02 -7.172502e-02 -7.331946e-02 -7.492947e-02
## ASV11966     3.477819e-02  3.605285e-02  3.735841e-02  3.869473e-02
## ASV12990     1.368653e-02  1.403403e-02  1.438728e-02  1.474630e-02
## ASV14797     1.940886e-02  1.988512e-02  2.036897e-02  2.086052e-02
## ASV14904    -1.006494e-01 -1.029143e-01 -1.052017e-01 -1.075114e-01
## ASV15304     2.553603e-02  2.652207e-02  2.753317e-02  2.856919e-02
## ASV16696    -3.477477e-02 -3.555731e-02 -3.634759e-02 -3.714561e-02
## ASV1690      1.032059e-01  1.065273e-01  1.099044e-01  1.133358e-01
## ASV2029      5.556310e-02  5.723563e-02  5.894322e-02  6.068605e-02
## ASV2834      8.118118e-02  8.376409e-02  8.639705e-02  8.907963e-02
## ASV4003      1.040603e-01  1.089052e-01  1.139607e-01  1.192346e-01
## ASV4064      4.090090e-02  4.231779e-02  4.377317e-02  4.526778e-02
## ASV4294      4.032991e-02  4.216144e-02  4.406279e-02  4.603565e-02
## ASV4609      1.964736e-02  2.031483e-02  2.100211e-02  2.170954e-02
## ASV6283     -3.250490e-02 -3.323632e-02 -3.397500e-02 -3.472092e-02
## ASV6491     -4.658877e-02 -4.763716e-02 -4.869597e-02 -4.976518e-02
## ASV7453      4.797256e-02  4.977667e-02  5.162699e-02  5.352348e-02
## ASV7959      2.774719e-02  2.907710e-02  3.046097e-02  3.190040e-02
## ASV8219      4.026233e-01  4.116849e-01  4.208367e-01  4.300788e-01
## ASV8547     -4.171069e-02 -4.264954e-02 -4.359777e-02 -4.455536e-02
## ASV9319      3.595971e-02  3.741364e-02  3.891944e-02  4.047856e-02
## ASV9382     -8.161301e-02 -8.345027e-02 -8.530590e-02 -8.717991e-02
## ASV11516    -5.451155e-02 -5.573888e-02 -5.697852e-02 -5.823046e-02
## ASV14377    -3.936090e-02 -4.024726e-02 -4.114252e-02 -4.204668e-02
## ASV1867      5.324644e-02  5.520133e-02  5.721675e-02  5.929414e-02
## ASV1895      8.797082e-03  8.669831e-03  8.520987e-03  8.349850e-03
## ASV3168      1.801248e-02  1.831697e-02  1.861778e-02  1.891466e-02
## ASV4449      1.640301e-01  1.697430e-01  1.756250e-01  1.816802e-01
## ASV6596      5.588086e-02  5.836500e-02  6.094055e-02  6.360930e-02
## ASV7492      1.091501e-02  1.164950e-02  1.241441e-02  1.321005e-02
## ASV9854     -7.851949e-03 -8.013161e-03 -8.175121e-03 -8.337835e-03
## ASV6296      6.605418e-01  6.754236e-01  6.904560e-01  7.056388e-01
## ASV4201      2.610507e-02  2.758135e-02  2.912704e-02  3.074452e-02
## ASV0552      3.419151e-02  3.529396e-02  3.641671e-02  3.755922e-02
## ASV3671     -2.455985e-02 -2.562916e-02 -2.674603e-02 -2.791225e-02
## ASV3529      4.775334e-03  5.059034e-03  5.348171e-03  5.642308e-03
## ASV1060      1.320568e-02  1.382456e-02  1.447092e-02  1.514581e-02
## ASV0239     -5.968428e-03 -6.033441e-03 -6.094318e-03 -6.150756e-03
## ASV5711     -4.550351e-02 -4.685313e-02 -4.822850e-02 -4.962945e-02
## ASV4152     -7.491082e-02 -7.729020e-02 -7.971480e-02 -8.218394e-02
## ASV1461      2.049116e-02  2.078365e-02  2.106965e-02  2.134881e-02
## ASV2877      1.084489e-02  1.095894e-02  1.106346e-02  1.115778e-02
## ASV0012      3.379613e-03  3.492636e-03  3.608475e-03  3.727154e-03
## ASV9823     -4.157071e-03 -4.580897e-03 -5.029895e-03 -5.504848e-03
## ASV0008      3.498923e-03  3.614780e-03  3.733543e-03  3.855237e-03
## ASV7832     -4.857629e-02 -5.030352e-02 -5.207696e-02 -5.389705e-02
## ASV1915     -6.268035e-03 -6.544126e-03 -6.831919e-03 -7.131787e-03
## ASV0055     -7.001829e-03 -7.322128e-03 -7.654910e-03 -8.000526e-03
## ASV0032      3.248100e-04  3.198244e-04  3.160558e-04  3.137747e-04
## ASV2977     -5.985576e-02 -6.167720e-02 -6.352880e-02 -6.540987e-02
## ASV0466      2.645703e-02  2.675290e-02  2.703242e-02  2.729478e-02
## ASV3866      4.214510e-02  4.382218e-02  4.555804e-02  4.735421e-02
## ASV0040      1.295449e-02  1.339208e-02  1.384011e-02  1.429860e-02
## ASV0496     -1.208065e-02 -1.267999e-02 -1.329946e-02 -1.393909e-02
## ASV0052      1.112280e-02  1.151928e-02  1.192781e-02  1.234870e-02
## ASV3828     -2.280783e-02 -2.329770e-02 -2.379108e-02 -2.428794e-02
## ASV1930      1.194847e-02  1.216264e-02  1.237471e-02  1.258451e-02
## ASV2126      2.833927e-02  2.923270e-02  3.014847e-02  3.108697e-02
## ASV0793      4.414096e-02  4.575221e-02  4.741239e-02  4.912277e-02
## ASV0299     -3.909350e-03 -4.209534e-03 -4.529764e-03 -4.870988e-03
## ASV0208      3.056418e-02  3.169211e-02  3.285629e-02  3.405764e-02
## ASV0511     -5.978644e-03 -6.097892e-03 -6.220701e-03 -6.347383e-03
## ASV1123     -1.911880e-02 -1.935360e-02 -1.957314e-02 -1.977602e-02
## ASV0099      3.032012e-03  3.202691e-03  3.381397e-03  3.568357e-03
## ASV0752     -2.645212e-02 -2.751794e-02 -2.862023e-02 -2.975986e-02
## ASV0883      3.339823e-02  3.458225e-02  3.579300e-02  3.703017e-02
## ASV0683      4.299833e-02  4.460165e-02  4.625120e-02  4.794751e-02
## ASV4117     -6.308007e-02 -6.540722e-02 -6.780542e-02 -7.027606e-02
## ASV2172     -1.421111e-03 -1.632860e-03 -1.859371e-03 -2.101289e-03
## ASV0330     -1.237644e-02 -1.285627e-02 -1.335289e-02 -1.386681e-02
## ASV0728      4.918052e-02  5.072344e-02  5.230285e-02  5.391943e-02
## ASV0499      1.751898e-02  1.819686e-02  1.889568e-02  1.961577e-02
## ASV0120     -2.124282e-02 -2.183807e-02 -2.243945e-02 -2.304642e-02
## ASV1446      3.071198e-04 -1.832670e-04 -7.120601e-04 -1.280865e-03
## ASV17171    -4.731052e-02 -4.903887e-02 -5.082097e-02 -5.265780e-02
## ASV0533      5.196531e-03  5.409562e-03  5.628969e-03  5.854785e-03
## ASV2495     -2.200191e-02 -2.300057e-02 -2.403233e-02 -2.509738e-02
## ASV5582      5.821342e-03  5.624880e-03  5.403317e-03  5.155195e-03
## ASV1488      3.983068e-03  3.960929e-03  3.928530e-03  3.885256e-03
## ASV0682      1.279079e-02  1.326720e-02  1.375612e-02  1.425753e-02
## ASV0068     -1.640484e-02 -1.685617e-02 -1.731067e-02 -1.776782e-02
## ASV1987     -5.837986e-02 -6.065833e-02 -6.300577e-02 -6.542304e-02
## ASV0035     -1.208150e-02 -1.280026e-02 -1.355624e-02 -1.435083e-02
## ASV7192     -2.190709e-02 -2.245324e-02 -2.300176e-02 -2.355210e-02
## ASV0873     -8.478190e-02 -8.899119e-02 -9.333164e-02 -9.780344e-02
## ASV4749     -2.055932e-02 -2.174081e-02 -2.297224e-02 -2.425468e-02
## ASV2174      5.988160e-03  5.853077e-03  5.700899e-03  5.531152e-03
## ASV1476     -2.646206e-02 -2.754310e-02 -2.866036e-02 -2.981460e-02
## ASV0740     -7.163171e-02 -7.453290e-02 -7.753640e-02 -8.064486e-02
## ASV0170     -1.131678e-02 -1.171510e-02 -1.212507e-02 -1.254695e-02
## ASV2466     -5.344350e-02 -5.536837e-02 -5.734861e-02 -5.938492e-02
## ASV1709      2.065203e-02  2.166422e-02  2.273333e-02  2.386248e-02
## ASV6170     -9.103624e-02 -9.441002e-02 -9.787997e-02 -1.014469e-01
## ASV3673      4.761611e-02  4.942781e-02  5.129154e-02  5.320766e-02
## ASV1745     -1.537638e-02 -1.602659e-02 -1.669850e-02 -1.739245e-02
##                                                                    
## (Intercept)  2.817601e-01  2.898402e-01  2.980431e-01  3.063664e-01
## ASV1236      4.402785e-02  4.513310e-02  4.625343e-02  4.738876e-02
## ASV0421      1.487765e-02  1.545069e-02  1.603574e-02  1.663256e-02
## ASV0691     -1.733245e-02 -1.744507e-02 -1.755031e-02 -1.764806e-02
## ASV0899      3.543617e-02  3.621086e-02  3.699281e-02  3.778219e-02
## ASV1004      8.660154e-02  8.867839e-02  9.077856e-02  9.290175e-02
## ASV1041     -2.743904e-02 -2.771842e-02 -2.797799e-02 -2.821687e-02
## ASV1058      5.517934e-02  5.657580e-02  5.799244e-02  5.942917e-02
## ASV12542     1.887220e-02  1.935086e-02  1.984031e-02  2.034086e-02
## ASV1294      5.273560e-02  5.415174e-02  5.559574e-02  5.706809e-02
## ASV13113     3.520403e-02  3.669326e-02  3.823551e-02  3.983194e-02
## ASV1318      5.066791e-02  5.194128e-02  5.323527e-02  5.455022e-02
## ASV2269     -7.945233e-02 -8.104221e-02 -8.263288e-02 -8.422360e-02
## ASV2542      6.888072e-02  7.141193e-02  7.401772e-02  7.669922e-02
## ASV2660     -3.161152e-02 -3.229711e-02 -3.298845e-02 -3.368546e-02
## ASV2737      9.163192e-03  9.377130e-03  9.595818e-03  9.819402e-03
## ASV2840      3.132610e-02  3.168714e-02  3.203688e-02  3.237511e-02
## ASV3053      2.112041e-01  2.160733e-01  2.210042e-01  2.259965e-01
## ASV3077      1.474687e-02  1.514325e-02  1.554803e-02  1.596137e-02
## ASV3134      5.110845e-02  5.318362e-02  5.532927e-02  5.754680e-02
## ASV3140      4.733462e-02  4.872436e-02  5.013769e-02  5.157429e-02
## ASV3579      2.891832e-02  3.005629e-02  3.122368e-02  3.242032e-02
## ASV6119     -2.175412e-02 -2.219365e-02 -2.263370e-02 -2.307398e-02
## ASV7557     -4.421971e-02 -4.511485e-02 -4.601104e-02 -4.690765e-02
## ASV8422      1.167206e-02  1.199862e-02  1.233390e-02  1.267822e-02
## ASV1086     -1.485275e-03 -1.543031e-03 -1.603549e-03 -1.666944e-03
## ASV1310      2.213051e-02  2.261188e-02  2.309477e-02  2.357892e-02
## ASV15750    -8.651337e-04 -8.108379e-04 -7.520202e-04 -6.885033e-04
## ASV16905    -9.103384e-03 -9.288670e-03 -9.474126e-03 -9.659593e-03
## ASV2033      6.816536e-02  7.051886e-02  7.293334e-02  7.540981e-02
## ASV2089      1.922968e-02  1.961847e-02  2.000723e-02  2.039559e-02
## ASV2127      6.823546e-02  6.992278e-02  7.163300e-02  7.336598e-02
## ASV2725      4.713396e-02  4.809536e-02  4.906161e-02  5.003260e-02
## ASV2804     -1.885851e-02 -1.924294e-02 -1.962756e-02 -2.001200e-02
## ASV3075      6.567979e-02  6.808040e-02  7.055673e-02  7.311015e-02
## ASV3327      9.302598e-02  9.613330e-02  9.931715e-02  1.025785e-01
## ASV3342      7.925848e-02  8.197449e-02  8.476290e-02  8.762463e-02
## ASV3532     -8.520905e-02 -8.828200e-02 -9.145596e-02 -9.473360e-02
## ASV3600      3.852395e-02  3.977185e-02  4.104804e-02  4.235260e-02
## ASV4013      5.744432e-02  5.892595e-02  6.042384e-02  6.193742e-02
## ASV4136      5.216969e-02  5.344446e-02  5.473729e-02  5.604806e-02
## ASV4195      1.926697e-01  1.965995e-01  2.005290e-01  2.044545e-01
## ASV4407     -7.445697e-02 -7.597510e-02 -7.749286e-02 -7.900883e-02
## ASV4717      9.835377e-03  1.006738e-02  1.030734e-02  1.055571e-02
## ASV6794      3.020425e-02  3.097700e-02  3.176645e-02  3.257301e-02
## ASV8324     -3.822530e-02 -3.900497e-02 -3.978430e-02 -4.056260e-02
## ASV8981      5.013649e-03  5.324055e-03  5.647072e-03  5.982862e-03
## ASV9859      4.145170e-02  4.348430e-02  4.560455e-02  4.781513e-02
## ASV0936      5.479297e-02  5.640597e-02  5.804459e-02  5.970839e-02
## ASV12683    -2.450114e-04 -2.087121e-04 -1.673269e-04 -1.205388e-04
## ASV1293      2.540394e-02  2.597314e-02  2.654723e-02  2.712613e-02
## ASV13055     3.543985e-03  3.763953e-03  3.993787e-03  4.233755e-03
## ASV17063    -1.984398e-02 -2.024750e-02 -2.065072e-02 -2.105335e-02
## ASV2228      1.618562e-02  1.651480e-02  1.684379e-02  1.717237e-02
## ASV2769      6.811367e-03  7.035988e-03  7.262673e-03  7.491134e-03
## ASV2803      1.436992e-02  1.465326e-02  1.494042e-02  1.523152e-02
## ASV2896      2.790748e-02  2.909906e-02  3.033909e-02  3.162930e-02
## ASV3062      3.681854e-02  3.819922e-02  3.961508e-02  4.106607e-02
## ASV3107      4.374532e-02  4.529314e-02  4.688322e-02  4.851601e-02
## ASV3265      3.531464e-02  3.607243e-02  3.683443e-02  3.760034e-02
## ASV3666     -8.659207e-04 -9.239790e-04 -9.839978e-04 -1.045971e-03
## ASV4497      1.386945e-02  1.422560e-02  1.458717e-02  1.495413e-02
## ASV6914     -5.327963e-03 -5.538061e-03 -5.753396e-03 -5.973962e-03
## ASV0576     -3.105091e-02 -3.148441e-02 -3.191179e-02 -3.233266e-02
## ASV0673      5.682404e-02  5.838126e-02  5.996828e-02  6.158555e-02
## ASV0772      3.017043e-02  3.113834e-02  3.213178e-02  3.315120e-02
## ASV0862      1.405055e-02  1.460540e-02  1.516938e-02  1.574206e-02
## ASV0898      2.971939e-02  3.071458e-02  3.173311e-02  3.277526e-02
## ASV0910      3.330654e-02  3.448084e-02  3.568689e-02  3.692505e-02
## ASV0964     -1.285568e-02 -1.307359e-02 -1.329194e-02 -1.351068e-02
## ASV10059     2.887723e-02  2.998036e-02  3.111479e-02  3.228074e-02
## ASV10263    -3.024533e-02 -3.086278e-02 -3.148062e-02 -3.209860e-02
## ASV1088      6.030272e-02  6.257960e-02  6.493046e-02  6.735690e-02
## ASV1101      4.314955e-02  4.407929e-02  4.501560e-02  4.595835e-02
## ASV1183      1.714854e-02  1.772874e-02  1.832587e-02  1.894038e-02
## ASV11956     8.898087e-03  9.100059e-03  9.307089e-03  9.519310e-03
## ASV12774    -3.539739e-03 -3.733679e-03 -3.934119e-03 -4.141123e-03
## ASV1321      8.818577e-02  9.120361e-02  9.429036e-02  9.744577e-02
## ASV13793    -2.086138e-02 -2.128854e-02 -2.171638e-02 -2.214476e-02
## ASV14482     1.602157e-03  1.680600e-03  1.762877e-03  1.849044e-03
## ASV15483     1.343987e-02  1.387548e-02  1.432150e-02  1.477808e-02
## ASV2062      5.126343e-02  5.275729e-02  5.428110e-02  5.583491e-02
## ASV2132      5.059428e-02  5.219519e-02  5.382814e-02  5.549294e-02
## ASV2413      3.606718e-02  3.707289e-02  3.810034e-02  3.914997e-02
## ASV2490      8.672173e-02  8.847101e-02  9.023028e-02  9.199933e-02
## ASV2594      2.122626e-02  2.207967e-02  2.296437e-02  2.388120e-02
## ASV2822     -5.506662e-02 -5.619943e-02 -5.733511e-02 -5.847341e-02
## ASV2863      6.055686e-02  6.201181e-02  6.348655e-02  6.498118e-02
## ASV2910      2.285018e-02  2.341916e-02  2.399760e-02  2.458567e-02
## ASV2980      2.992887e-02  3.075747e-02  3.160082e-02  3.245900e-02
## ASV3307      4.384845e-02  4.475540e-02  4.566550e-02  4.657858e-02
## ASV3474      5.377044e-02  5.568821e-02  5.765424e-02  5.966867e-02
## ASV3502      4.430565e-02  4.577245e-02  4.728016e-02  4.882971e-02
## ASV4236      3.721576e-02  3.785544e-02  3.849418e-02  3.913179e-02
## ASV4842     -3.681801e-03 -3.639312e-03 -3.588006e-03 -3.527664e-03
## ASV4894     -2.089767e-02 -2.133197e-02 -2.176805e-02 -2.220581e-02
## ASV5290      2.500420e-02  2.581978e-02  2.665704e-02  2.751650e-02
## ASV5501      1.869331e-02  1.949118e-02  2.032115e-02  2.118419e-02
## ASV5795      1.722094e-02  1.775970e-02  1.830850e-02  1.886718e-02
## ASV5987     -5.840874e-02 -5.962877e-02 -6.085444e-02 -6.208549e-02
## ASV6267     -6.584053e-02 -6.721883e-02 -6.860382e-02 -6.999520e-02
## ASV6862      2.577350e-02  2.638029e-02  2.699586e-02  2.762024e-02
## ASV7145      1.301835e-02  1.343065e-02  1.385480e-02  1.429100e-02
## ASV7673     -2.093326e-02 -2.137298e-02 -2.181496e-02 -2.225910e-02
## ASV7789      2.819823e-02  2.943652e-02  3.071872e-02  3.204574e-02
## ASV7809      5.757932e-03  6.012901e-03  6.274212e-03  6.541785e-03
## ASV8002     -2.646633e-02 -2.702552e-02 -2.758786e-02 -2.815320e-02
## ASV8205      1.718706e-02  1.775369e-02  1.833292e-02  1.892471e-02
## ASV9155     -4.972890e-03 -5.019978e-03 -5.064311e-03 -5.105789e-03
## ASV9221      1.420066e-02  1.491615e-02  1.566087e-02  1.643573e-02
## ASV9311     -4.252726e-02 -4.343251e-02 -4.434327e-02 -4.525929e-02
## ASV9557     -2.908034e-02 -2.970059e-02 -3.032466e-02 -3.095237e-02
## ASV9936     -5.867754e-02 -5.993144e-02 -6.119316e-02 -6.246233e-02
## ASV1445      5.296234e-02  5.462221e-02  5.631554e-02  5.804209e-02
## ASV4232      3.327159e-02  3.483539e-02  3.646655e-02  3.816724e-02
## ASV6479      2.154979e-02  2.262584e-02  2.374477e-02  2.490754e-02
## ASV0142     -2.574478e-02 -2.635055e-02 -2.696413e-02 -2.758557e-02
## ASV0378      2.169645e-02  2.241604e-02  2.314753e-02  2.389041e-02
## ASV1122      5.511364e-02  5.698033e-02  5.889435e-02  6.085614e-02
## ASV0123     -2.220539e-02 -2.270543e-02 -2.321037e-02 -2.372017e-02
## ASV2064      4.205922e-03  4.020081e-03  3.815862e-03  3.592711e-03
## ASV4459     -1.273434e-03 -1.367500e-03 -1.469853e-03 -1.580880e-03
## ASV0448      1.825462e-02  1.892037e-02  1.960234e-02  2.030038e-02
## ASV0397      2.634281e-02  2.709315e-02  2.785716e-02  2.863487e-02
## ASV0485      2.866063e-02  2.945413e-02  3.026153e-02  3.108278e-02
## ASV1566      4.451232e-02  4.576574e-02  4.704043e-02  4.833624e-02
## ASV1365      3.898687e-02  4.003020e-02  4.108702e-02  4.215730e-02
## ASV1065      5.859604e-02  6.035043e-02  6.213831e-02  6.395960e-02
## ASV0722     -5.604913e-03 -5.881916e-03 -6.171530e-03 -6.474191e-03
## ASV12660    -2.327876e-02 -2.378092e-02 -2.428710e-02 -2.479725e-02
## ASV0223      8.807175e-03  9.094707e-03  9.390203e-03  9.693776e-03
## ASV0229      1.687430e-02  1.750011e-02  1.814641e-02  1.881375e-02
## ASV0877     -3.980128e-03 -4.499005e-03 -5.054292e-03 -5.647544e-03
## ASV0983      2.565945e-02  2.626305e-02  2.687123e-02  2.748372e-02
## ASV0626      1.075018e-02  1.119682e-02  1.165572e-02  1.212699e-02
## ASV4146     -4.410609e-03 -4.853849e-03 -5.326549e-03 -5.829676e-03
## ASV4175     -4.338170e-02 -4.472618e-02 -4.609594e-02 -4.749072e-02
## ASV2082     -4.412455e-02 -4.619356e-02 -4.833761e-02 -5.055778e-02
## ASV2272      2.218546e-02  2.297448e-02  2.378657e-02  2.462217e-02
## ASV2245     -3.195198e-02 -3.295474e-02 -3.397641e-02 -3.501680e-02
## ASV0590     -4.564018e-02 -4.780774e-02 -5.005647e-02 -5.238788e-02
## ASV0217      1.379099e-02  1.447716e-02  1.518860e-02  1.592590e-02
## ASV0416      5.667218e-03  5.467152e-03  5.248642e-03  5.011288e-03
## ASV1056      3.369936e-02  3.480383e-02  3.593051e-02  3.707918e-02
## ASV7777     -4.571586e-02 -4.745965e-02 -4.927031e-02 -5.115074e-02
## ASV0455      6.186264e-03  6.322902e-03  6.458130e-03  6.591630e-03
## ASV0604      2.436584e-02  2.523480e-02  2.612597e-02  2.703946e-02
## ASV6100     -3.487881e-02 -3.626416e-02 -3.770109e-02 -3.919131e-02
## ASV11359    -5.835643e-02 -6.001086e-02 -6.168701e-02 -6.338415e-02
## ASV6604      1.001190e-02  1.031753e-02  1.062524e-02  1.093447e-02
## ASV5004     -2.226877e-02 -2.304031e-02 -2.383453e-02 -2.465181e-02
## ASV1483     -8.112866e-03 -8.322163e-03 -8.532445e-03 -8.743429e-03
## ASV9773     -3.077635e-02 -3.188918e-02 -3.303650e-02 -3.421910e-02
## ASV4059      9.483002e-03  9.915363e-03  1.035472e-02  1.080022e-02
## ASV1193      3.051865e-02  3.142869e-02  3.235654e-02  3.330214e-02
## ASV4610      4.088446e-03  4.280743e-03  4.472137e-03  4.662019e-03
## ASV0742      5.936609e-03  6.232915e-03  6.534877e-03  6.842224e-03
## ASV1502     -7.712510e-03 -8.038891e-03 -8.371931e-03 -8.711357e-03
## ASV0195     -3.055036e-03 -3.224523e-03 -3.400336e-03 -3.582610e-03
## ASV1213      1.138577e-02  1.150006e-02  1.160796e-02  1.170914e-02
## ASV1648     -3.184939e-02 -3.314000e-02 -3.447892e-02 -3.586753e-02
## ASV6984     -3.056563e-02 -3.182543e-02 -3.313321e-02 -3.449040e-02
## ASV0396      3.073518e-04  2.163420e-04  1.096584e-04 -1.403081e-05
## ASV4297      2.027506e-02  2.067940e-02  2.108867e-02  2.150321e-02
## ASV2622      3.965803e-02  4.066675e-02  4.169082e-02  4.273027e-02
## ASV3512      4.008645e-02  4.197568e-02  4.394247e-02  4.598910e-02
## ASV2411      4.448851e-02  4.603725e-02  4.761965e-02  4.923516e-02
## ASV2291     -3.859994e-02 -4.031981e-02 -4.209533e-02 -4.392710e-02
## ASV0807      4.261784e-02  4.378842e-02  4.497908e-02  4.619014e-02
## ASV1292      4.915846e-03  5.003461e-03  5.096654e-03  5.196063e-03
## ASV1035      3.384990e-02  3.478450e-02  3.574045e-02  3.671829e-02
## ASV0070      5.944752e-03  6.269497e-03  6.607182e-03  6.958038e-03
## ASV0255     -1.036983e-03 -1.269255e-03 -1.519356e-03 -1.788069e-03
## ASV0057     -5.237933e-03 -5.241204e-03 -5.238251e-03 -5.228899e-03
## ASV0077     -2.428716e-05 -1.389986e-05 -6.993569e-06 -4.120710e-06
## ASV0625      1.595993e-02  1.626816e-02  1.657724e-02  1.688712e-02
## ASV2464      1.131732e-01  1.156038e-01  1.180528e-01  1.205197e-01
## ASV1315      5.995871e-02  6.210872e-02  6.431091e-02  6.656501e-02
## ASV2673      5.270246e-02  5.466630e-02  5.668504e-02  5.875913e-02
## ASV2161      2.332373e-02  2.426047e-02  2.522839e-02  2.622802e-02
## ASV0337     -1.056292e-02 -1.092753e-02 -1.130206e-02 -1.168660e-02
## ASV7680     -7.078268e-02 -7.317857e-02 -7.563033e-02 -7.813777e-02
## ASV0611      4.159870e-02  4.312855e-02  4.470543e-02  4.633036e-02
## ASV3118     -4.915906e-02 -5.097670e-02 -5.284338e-02 -5.475949e-02
## ASV1284     -2.590022e-02 -2.784446e-02 -2.989311e-02 -3.204982e-02
## ASV0889      2.360019e-02  2.438491e-02  2.519615e-02  2.603494e-02
## ASV4649     -1.381174e-02 -1.427507e-02 -1.475057e-02 -1.523840e-02
## ASV1108     -4.181850e-02 -4.348922e-02 -4.521076e-02 -4.698373e-02
## ASV0738      3.282203e-02  3.438626e-02  3.601540e-02  3.771156e-02
## ASV0473     -5.355460e-03 -5.435468e-03 -5.503179e-03 -5.557147e-03
## ASV0598     -2.055761e-02 -2.157544e-02 -2.263380e-02 -2.373355e-02
## ASV0429      1.161193e-02  1.177632e-02  1.193683e-02  1.209340e-02
## ASV1549      4.860208e-02  5.035248e-02  5.214334e-02  5.397403e-02
## ASV1203      2.298933e-02  2.355394e-02  2.412329e-02  2.469711e-02
## ASV4532      9.343319e-04  1.032954e-03  1.141447e-03  1.260461e-03
## ASV0274      6.237677e-03  6.376642e-03  6.510891e-03  6.639745e-03
## ASV0163     -1.544669e-02 -1.586827e-02 -1.630180e-02 -1.674779e-02
## ASV1298      3.792694e-03  4.089180e-03  4.407641e-03  4.749198e-03
## ASV9424     -6.128596e-02 -6.366376e-02 -6.612148e-02 -6.866101e-02
## ASV0412      3.916696e-02  4.017400e-02  4.119635e-02  4.223416e-02
## ASV0284     -7.049791e-04 -1.048403e-03 -1.417573e-03 -1.813646e-03
## ASV0620     -2.066052e-02 -2.155628e-02 -2.248228e-02 -2.343904e-02
## ASV0153     -6.303210e-02 -6.524917e-02 -6.751703e-02 -6.983530e-02
## ASV0498      1.602942e-02  1.639243e-02  1.675176e-02  1.710672e-02
## ASV0097      1.277079e-02  1.322987e-02  1.369946e-02  1.417938e-02
## ASV0104     -5.693834e-02 -5.839361e-02 -5.986408e-02 -6.134922e-02
## ASV1282      9.944201e-03  9.813402e-03  9.654733e-03  9.466869e-03
## ASV3883     -2.818047e-02 -2.917174e-02 -3.018035e-02 -3.120544e-02
## ASV0801      1.169962e-02  1.220034e-02  1.272292e-02  1.326822e-02
## ASV1611     -5.574344e-02 -5.779814e-02 -5.990975e-02 -6.207874e-02
## ASV0227     -1.810167e-02 -1.891685e-02 -1.976139e-02 -2.063596e-02
## ASV0833      1.528985e-02  1.577001e-02  1.626050e-02  1.676139e-02
## ASV0718      6.937083e-02  7.160126e-02  7.388060e-02  7.620889e-02
## ASV1139     -5.692856e-03 -6.213069e-03 -6.757790e-03 -7.327362e-03
## ASV0766     -1.422478e-02 -1.473716e-02 -1.526015e-02 -1.579357e-02
## ASV2091      3.202707e-02  3.254897e-02  3.306496e-02  3.357474e-02
## ASV1238     -6.867826e-02 -7.164236e-02 -7.472571e-02 -7.793205e-02
## ASV9193     -2.014154e-02 -2.122442e-02 -2.235352e-02 -2.352990e-02
## ASV0290      2.635254e-03  2.736926e-03  2.847598e-03  2.967799e-03
## ASV0231      1.384176e-02  1.408818e-02  1.432907e-02  1.456384e-02
## ASV0185      2.445834e-02  2.559281e-02  2.677111e-02  2.799434e-02
## ASV2330      1.258120e-02  1.283089e-02  1.308489e-02  1.334341e-02
## ASV3119     -2.086129e-02 -2.179854e-02 -2.276997e-02 -2.377630e-02
## ASV2368     -3.990871e-02 -4.167426e-02 -4.350837e-02 -4.541278e-02
## ASV0122     -1.037762e-02 -1.066945e-02 -1.096725e-02 -1.127114e-02
## ASV1044      4.106985e-02  4.265593e-02  4.429331e-02  4.598309e-02
## ASV0160     -8.244557e-03 -8.465843e-03 -8.695256e-03 -8.933274e-03
## ASV0326      2.682286e-03  2.711426e-03  2.736725e-03  2.757860e-03
## ASV1388      5.312378e-02  5.451069e-02  5.591579e-02  5.733888e-02
## ASV0792      3.224775e-02  3.292488e-02  3.360502e-02  3.428808e-02
## ASV0036     -1.799952e-02 -1.857682e-02 -1.916248e-02 -1.975600e-02
## ASV2125      3.970288e-02  4.074605e-02  4.179978e-02  4.286348e-02
## ASV1075     -1.893951e-03 -2.018039e-03 -2.149266e-03 -2.287890e-03
## ASV0390      3.590104e-02  3.741645e-02  3.898733e-02  4.061499e-02
## ASV3790     -3.913778e-02 -4.050247e-02 -4.190370e-02 -4.334189e-02
## ASV1535     -1.792427e-02 -1.864092e-02 -1.937668e-02 -2.013150e-02
## ASV0263      4.209631e-02  4.340513e-02  4.474093e-02  4.610369e-02
## ASV0675      7.605198e-02  7.874814e-02  8.151527e-02  8.435391e-02
## ASV3348      7.636591e-03  7.906321e-03  8.180750e-03  8.459594e-03
## ASV0058     -1.511361e-02 -1.548380e-02 -1.585714e-02 -1.623345e-02
## ASV4142      1.767530e-02  1.807977e-02  1.849080e-02  1.890863e-02
## ASV0059     -1.138925e-02 -1.165014e-02 -1.191290e-02 -1.217749e-02
## ASV0013     -2.598186e-02 -2.677188e-02 -2.757844e-02 -2.840167e-02
## ASV0033     -1.566533e-02 -1.618273e-02 -1.670946e-02 -1.724526e-02
## ASV4354     -1.778892e-02 -1.841360e-02 -1.905374e-02 -1.970927e-02
## ASV0022     -1.345780e-02 -1.391458e-02 -1.438030e-02 -1.485472e-02
## ASV0134     -1.785618e-02 -1.868223e-02 -1.954419e-02 -2.044340e-02
## ASV0415      3.096011e-03  3.200279e-03  3.306456e-03  3.414564e-03
## ASV10103    -7.233609e-02 -7.488153e-02 -7.748993e-02 -8.016130e-02
## ASV1613      2.806295e-02  2.847621e-02  2.887623e-02  2.926222e-02
## ASV0135     -2.341770e-03 -2.337428e-03 -2.329920e-03 -2.319148e-03
## ASV0469     -5.027287e-02 -5.179121e-02 -5.334630e-02 -5.493882e-02
## ASV0471      3.498105e-02  3.616432e-02  3.738438e-02  3.864245e-02
## ASV0451     -1.422466e-02 -1.483323e-02 -1.545913e-02 -1.610241e-02
## ASV0747      1.977617e-02  2.033745e-02  2.090527e-02  2.147928e-02
## ASV1314     -3.032729e-02 -3.160454e-02 -3.292746e-02 -3.429711e-02
## ASV0425     -4.817283e-02 -4.924138e-02 -5.032060e-02 -5.141043e-02
## ASV0559     -2.088195e-02 -2.174238e-02 -2.263552e-02 -2.356212e-02
## ASV0148      3.837857e-03  4.186061e-03  4.554164e-03  4.942918e-03
## ASV0129      1.858478e-02  1.956880e-02  2.059343e-02  2.165956e-02
## ASV1072     -5.779053e-04 -7.347292e-04 -9.003424e-04 -1.074827e-03
## ASV2390      1.524124e-02  1.519460e-02  1.512646e-02  1.503630e-02
## ASV0548      2.162557e-02  2.222755e-02  2.283926e-02  2.346070e-02
## ASV0168     -1.009624e-02 -1.037259e-02 -1.065416e-02 -1.094103e-02
## ASV0066     -1.054968e-02 -1.075619e-02 -1.095936e-02 -1.115873e-02
## ASV0468     -8.395206e-03 -8.713375e-03 -9.042833e-03 -9.383925e-03
## ASV0172      4.190616e-04  5.573467e-04  7.047249e-04  8.614914e-04
## ASV0236      1.503576e-02  1.586616e-02  1.672744e-02  1.761986e-02
## ASV0250      3.678962e-02  3.846590e-02  4.020744e-02  4.201597e-02
## ASV0338      9.568186e-03  9.795598e-03  1.002082e-02  1.024331e-02
## ASV0450     -5.645365e-03 -5.928384e-03 -6.222126e-03 -6.526693e-03
## ASV0377      1.317357e-02  1.343242e-02  1.368694e-02  1.393652e-02
## ASV1022      1.774548e-03  1.951689e-03  2.141646e-03  2.345072e-03
## ASV6174     -2.050134e-03 -2.086512e-03 -2.114864e-03 -2.134065e-03
## ASV0786     -6.864042e-03 -7.108065e-03 -7.353299e-03 -7.599167e-03
## ASV0053     -1.869236e-02 -1.926010e-02 -1.983897e-02 -2.042900e-02
## ASV0697     -9.186931e-03 -9.476417e-03 -9.776914e-03 -1.008912e-02
## ASV0785      2.009125e-02  2.065092e-02  2.122326e-02  2.180878e-02
## ASV1967     -2.000083e-02 -2.054845e-02 -2.110407e-02 -2.166747e-02
## ASV0385      9.282445e-03  9.518745e-03  9.752640e-03  9.983505e-03
## ASV0295      7.105542e-03  7.487189e-03  7.885080e-03  8.299633e-03
## ASV0072     -1.189199e-02 -1.205805e-02 -1.221728e-02 -1.236928e-02
## ASV0157      6.985728e-03  7.491837e-03  8.024649e-03  8.585059e-03
## ASV0501      3.972246e-02  4.082528e-02  4.194014e-02  4.306649e-02
## ASV10729    -5.710657e-02 -5.903518e-02 -6.101114e-02 -6.303484e-02
## ASV1470      1.027449e-02  1.017020e-02  1.004204e-02  9.888901e-03
## ASV0050     -3.606534e-02 -3.695991e-02 -3.786240e-02 -3.877242e-02
## ASV0411     -1.363698e-02 -1.420511e-02 -1.479601e-02 -1.541058e-02
## ASV0549      1.846578e-02  1.908288e-02  1.971328e-02  2.035686e-02
## ASV0184      6.082975e-03  6.340556e-03  6.610008e-03  6.891913e-03
## ASV0705      6.220080e-03  6.262068e-03  6.295258e-03  6.319008e-03
## ASV1715      2.206390e-02  2.273041e-02  2.340968e-02  2.410171e-02
## ASV0603      6.688979e-03  7.047205e-03  7.423332e-03  7.817978e-03
## ASV0826      3.477231e-02  3.582227e-02  3.689599e-02  3.799382e-02
## ASV0034     -8.559026e-03 -8.734242e-03 -8.909379e-03 -9.084353e-03
## ASV0838     -1.684323e-02 -1.827037e-02 -1.978483e-02 -2.139012e-02
## ASV0614     -9.365537e-03 -9.642753e-03 -9.926146e-03 -1.021585e-02
## ASV0014     -2.492371e-02 -2.562271e-02 -2.633241e-02 -2.705264e-02
## ASV0585     -8.612767e-03 -9.071247e-03 -9.540392e-03 -1.001967e-02
## ASV0016     -2.612392e-02 -2.686089e-02 -2.760953e-02 -2.836970e-02
## ASV5394     -2.131281e-02 -2.189664e-02 -2.248214e-02 -2.306813e-02
## ASV0666      3.231981e-02  3.301945e-02  3.372425e-02  3.443422e-02
## ASV2085     -1.066367e-02 -1.153062e-02 -1.244216e-02 -1.339977e-02
## ASV0003     -1.779456e-02 -1.830034e-02 -1.881466e-02 -1.933749e-02
## ASV0346      1.162822e-02  1.197661e-02  1.232876e-02  1.268438e-02
## ASV0267      2.500303e-03  2.538290e-03  2.567127e-03  2.585679e-03
## ASV0353      1.939974e-02  2.009077e-02  2.079936e-02  2.152552e-02
## ASV2419      3.498573e-02  3.583312e-02  3.668139e-02  3.752923e-02
## ASV0447      2.849425e-02  2.952420e-02  3.058389e-02  3.167391e-02
## ASV0654      3.058384e-02  3.141783e-02  3.226339e-02  3.312037e-02
## ASV0151      9.794271e-03  1.021693e-02  1.065195e-02  1.109929e-02
## ASV0065     -1.108921e-02 -1.138676e-02 -1.168914e-02 -1.199636e-02
## ASV0527      2.889826e-02  2.969005e-02  3.049163e-02  3.130253e-02
## ASV4055     -1.253476e-02 -1.327044e-02 -1.404873e-02 -1.487186e-02
## ASV0166     -1.117663e-02 -1.142715e-02 -1.168141e-02 -1.193965e-02
## ASV0417     -2.069298e-03 -2.040127e-03 -2.008438e-03 -1.974450e-03
## ASV0078     -5.829603e-03 -5.878620e-03 -5.920493e-03 -5.954720e-03
## ASV0322      6.391603e-03  6.869731e-03  7.372699e-03  7.901164e-03
## ASV0156     -2.706113e-02 -2.806925e-02 -2.911056e-02 -3.018601e-02
## ASV0648     -5.751787e-02 -5.945906e-02 -6.144174e-02 -6.346523e-02
## ASV0407     -6.016950e-03 -6.285698e-03 -6.565085e-03 -6.855411e-03
## ASV2030     -1.180241e-02 -1.237097e-02 -1.296401e-02 -1.358211e-02
## ASV0300      7.674156e-03  7.934948e-03  8.200701e-03  8.471278e-03
## ASV1150      2.312178e-03  2.376211e-03  2.438903e-03  2.499954e-03
## ASV0958      2.791537e-02  2.908624e-02  3.029849e-02  3.155307e-02
## ASV0216     -2.086544e-02 -2.167113e-02 -2.250842e-02 -2.337840e-02
## ASV0446      3.394443e-02  3.503113e-02  3.613886e-02  3.726739e-02
## ASV0367     -2.111580e-02 -2.179380e-02 -2.248615e-02 -2.319277e-02
## ASV0200     -1.151170e-02 -1.181923e-02 -1.212776e-02 -1.243679e-02
## ASV0334     -1.861196e-03 -1.907361e-03 -1.960007e-03 -2.019810e-03
## ASV1311      8.244798e-04  6.594804e-04  4.815271e-04  2.901338e-04
## ASV0458      1.984135e-03  1.838872e-03  1.682771e-03  1.515618e-03
## ASV1371      2.133127e-03  2.165244e-03  2.194504e-03  2.220680e-03
## ASV0418      1.795461e-02  1.833886e-02  1.872596e-02  1.911602e-02
## ASV0004      2.349394e-03  2.391145e-03  2.432662e-03  2.473914e-03
## ASV1943      2.080599e-02  2.063496e-02  2.044195e-02  2.022701e-02
## ASV1495     -1.910062e-02 -2.006994e-02 -2.107671e-02 -2.212152e-02
## ASV0901     -3.012962e-02 -3.134996e-02 -3.261433e-02 -3.392390e-02
## ASV0628      3.775795e-03  3.659799e-03  3.528597e-03  3.381412e-03
## ASV0400      3.421936e-03  3.368955e-03  3.303329e-03  3.224218e-03
## ASV0116     -8.375160e-03 -8.692557e-03 -9.019902e-03 -9.357391e-03
## ASV0788      7.697766e-02  8.004004e-02  8.321238e-02  8.649822e-02
## ASV0117      6.463938e-03  6.717317e-03  6.978604e-03  7.247989e-03
## ASV3137     -6.153760e-04 -5.921790e-04 -5.643879e-04 -5.316002e-04
## ASV0001      2.363253e-03  2.405595e-03  2.448496e-03  2.492043e-03
## ASV1651      7.951132e-03  8.144832e-03  8.343674e-03  8.548068e-03
## ASV1692      6.108930e-02  6.340414e-02  6.579564e-02  6.826604e-02
## ASV0660      2.851137e-03  2.541585e-03  2.207612e-03  1.848647e-03
## ASV0508     -7.314098e-05 -1.160550e-04 -1.634773e-04 -2.157501e-04
## ASV1660     -1.512618e-02 -1.565215e-02 -1.618628e-02 -1.672798e-02
## ASV0233      1.568874e-02  1.620313e-02  1.673063e-02  1.727149e-02
## ASV1343     -3.461619e-02 -3.593531e-02 -3.729763e-02 -3.870419e-02
## ASV0209      7.417653e-03  7.481340e-03  7.537877e-03  7.586823e-03
## ASV0193     -8.845487e-03 -8.909319e-03 -8.963515e-03 -9.007549e-03
## ASV0357      1.580128e-02  1.661657e-02  1.746775e-02  1.835583e-02
## ASV0198      1.106685e-02  1.142012e-02  1.178335e-02  1.215678e-02
## ASV0007      1.649203e-03  1.664870e-03  1.680413e-03  1.695916e-03
## ASV1772      6.092087e-03  6.860372e-03  7.692709e-03  8.593149e-03
## ASV0009      1.020919e-03  1.019969e-03  1.018896e-03  1.017821e-03
## ASV0006     -4.746601e-03 -4.924877e-03 -5.107808e-03 -5.295400e-03
## ASV0011     -1.315351e-02 -1.361122e-02 -1.408110e-02 -1.456328e-02
## ASV0015      5.258231e-04  5.000002e-04  4.717426e-04  4.409605e-04
## ASV0017      7.972953e-04  7.836808e-04  7.682483e-04  7.509342e-04
## ASV0235     -1.282011e-02 -1.329907e-02 -1.379383e-02 -1.430485e-02
## ASV0382      6.077404e-03  6.083328e-03  6.073582e-03  6.046993e-03
## ASV2357      4.042621e-02  4.186377e-02  4.333890e-02  4.485159e-02
## ASV0567     -1.033936e-02 -1.082329e-02 -1.132853e-02 -1.185578e-02
## ASV0165      6.078717e-03  6.267339e-03  6.459741e-03  6.655951e-03
## ASV0005      7.237120e-03  7.421427e-03  7.607172e-03  7.794231e-03
## ASV0384      4.030813e-03  4.321034e-03  4.627560e-03  4.951057e-03
## ASV0002      1.230938e-03  1.265291e-03  1.300248e-03  1.335797e-03
## ASV3017      2.732965e-02  2.778651e-02  2.823796e-02  2.868369e-02
## ASV0091     -1.793018e-03 -1.901473e-03 -2.016946e-03 -2.139826e-03
## ASV0186     -1.482779e-02 -1.518820e-02 -1.554926e-02 -1.591062e-02
## ASV0370      7.492517e-03  7.717941e-03  7.950320e-03  8.189999e-03
## ASV0018      9.716334e-03  9.981931e-03  1.025102e-02  1.052350e-02
## ASV1377      7.503835e-02  7.664415e-02  7.825868e-02  7.988186e-02
## ASV0019      1.039189e-02  1.068443e-02  1.098146e-02  1.128292e-02
## ASV0023     -8.022246e-03 -8.277761e-03 -8.537638e-03 -8.801754e-03
## ASV2194      1.637347e-02  1.704839e-02  1.774659e-02  1.846855e-02
## ASV1155      3.716015e-02  3.831044e-02  3.949506e-02  4.071531e-02
## ASV0510     -5.941924e-03 -6.072664e-03 -6.207662e-03 -6.347024e-03
## ASV2371     -2.009793e-02 -2.056744e-02 -2.103972e-02 -2.151454e-02
## ASV0024     -9.878935e-03 -1.019574e-02 -1.051837e-02 -1.084673e-02
## ASV2452      1.096897e-02  1.094596e-02  1.090968e-02  1.085990e-02
## ASV2332     -6.684492e-02 -6.882464e-02 -7.084715e-02 -7.291273e-02
## ASV2591      2.966220e-02  3.059687e-02  3.154356e-02  3.250166e-02
## ASV0521      2.125738e-02  2.202241e-02  2.280933e-02  2.361851e-02
## ASV5542      1.876071e-02  1.938568e-02  2.002646e-02  2.068326e-02
## ASV0336     -6.540531e-03 -6.873432e-03 -7.222224e-03 -7.587693e-03
## ASV10102     3.420301e-02  3.527199e-02  3.636079e-02  3.746922e-02
## ASV16823    -3.049305e-02 -3.114760e-02 -3.180839e-02 -3.247545e-02
## ASV3104      1.577609e-01  1.611463e-01  1.645641e-01  1.680142e-01
## ASV0781      3.456121e-02  3.570833e-02  3.688786e-02  3.810049e-02
## ASV10899     4.127225e-02  4.310569e-02  4.500528e-02  4.697243e-02
## ASV11222    -5.365964e-02 -5.481079e-02 -5.597290e-02 -5.714601e-02
## ASV11327    -4.817253e-02 -4.920576e-02 -5.024883e-02 -5.130177e-02
## ASV12458    -5.365037e-02 -5.480090e-02 -5.596239e-02 -5.713488e-02
## ASV1636      3.749649e-02  3.846755e-02  3.945461e-02  4.045788e-02
## ASV1890     -1.875079e-02 -1.911312e-02 -1.948606e-02 -1.987053e-02
## ASV2898      5.091374e-02  5.226454e-02  5.364099e-02  5.504365e-02
## ASV8328      3.991716e-02  4.193278e-02  4.402220e-02  4.618624e-02
## ASV0709     -6.087117e-02 -6.247598e-02 -6.410245e-02 -6.575023e-02
## ASV0856      7.564368e-02  7.828805e-02  8.099425e-02  8.376204e-02
## ASV0909      4.261154e-02  4.452117e-02  4.649484e-02  4.853350e-02
## ASV0937     -5.528808e-02 -5.751295e-02 -5.981472e-02 -6.219486e-02
## ASV11390    -7.655504e-02 -7.819622e-02 -7.985304e-02 -8.152558e-02
## ASV11966     4.006162e-02  4.145885e-02  4.288615e-02  4.434320e-02
## ASV12990     1.511106e-02  1.548150e-02  1.585758e-02  1.623920e-02
## ASV14797     2.135985e-02  2.186705e-02  2.238219e-02  2.290535e-02
## ASV14904    -1.098434e-01 -1.121979e-01 -1.145749e-01 -1.169744e-01
## ASV15304     2.962997e-02  3.071532e-02  3.182501e-02  3.295877e-02
## ASV16696    -3.795137e-02 -3.876489e-02 -3.958619e-02 -4.041531e-02
## ASV1690      1.168196e-01  1.203543e-01  1.239377e-01  1.275681e-01
## ASV2029      6.246428e-02  6.427809e-02  6.612761e-02  6.801296e-02
## ASV2834      9.181134e-02  9.459167e-02  9.742007e-02  1.002960e-01
## ASV4003      1.247349e-01  1.304699e-01  1.364478e-01  1.426773e-01
## ASV4064      4.680239e-02  4.837778e-02  4.999476e-02  5.165415e-02
## ASV4294      4.808170e-02  5.020257e-02  5.239989e-02  5.467526e-02
## ASV4609      2.243746e-02  2.318619e-02  2.395604e-02  2.474728e-02
## ASV6283     -3.547410e-02 -3.623454e-02 -3.700227e-02 -3.777734e-02
## ASV6491     -5.084480e-02 -5.193485e-02 -5.303539e-02 -5.414645e-02
## ASV7453      5.546602e-02  5.745444e-02  5.948853e-02  6.156803e-02
## ASV7959      3.339702e-02  3.495247e-02  3.656841e-02  3.824651e-02
## ASV8219      4.394111e-01  4.488339e-01  4.583477e-01  4.679529e-01
## ASV8547     -4.552233e-02 -4.649870e-02 -4.748450e-02 -4.847980e-02
## ASV9319      4.209243e-02  4.376253e-02  4.549036e-02  4.727742e-02
## ASV9382     -8.907231e-02 -9.098315e-02 -9.291251e-02 -9.486050e-02
## ASV11516    -5.949471e-02 -6.077131e-02 -6.206031e-02 -6.336179e-02
## ASV14377    -4.295975e-02 -4.388177e-02 -4.481276e-02 -4.575279e-02
## ASV1867      6.143498e-02  6.364078e-02  6.591302e-02  6.825323e-02
## ASV1895      8.155745e-03  7.938024e-03  7.696064e-03  7.429274e-03
## ASV3168      1.920732e-02  1.949548e-02  1.977887e-02  2.005724e-02
## ASV4449      1.879124e-01  1.943259e-01  2.009247e-01  2.077132e-01
## ASV6596      6.637293e-02  6.923306e-02  7.219119e-02  7.524872e-02
## ASV7492      1.403666e-02  1.489441e-02  1.578341e-02  1.670371e-02
## ASV9854     -8.501317e-03 -8.665599e-03 -8.830722e-03 -8.996743e-03
## ASV6296      7.209724e-01  7.364572e-01  7.520939e-01  7.678835e-01
## ASV4201      3.243623e-02  3.420468e-02  3.605238e-02  3.798192e-02
## ASV0552      3.872091e-02  3.990114e-02  4.109922e-02  4.231439e-02
## ASV3671     -2.912961e-02 -3.039993e-02 -3.172501e-02 -3.310663e-02
## ASV3529      5.940985e-03  6.243718e-03  6.549999e-03  6.859296e-03
## ASV1060      1.585027e-02  1.658539e-02  1.735225e-02  1.815198e-02
## ASV0239     -6.202442e-03 -6.249046e-03 -6.290224e-03 -6.325615e-03
## ASV5711     -5.105576e-02 -5.250719e-02 -5.398348e-02 -5.548432e-02
## ASV4152     -8.469683e-02 -8.725265e-02 -8.985053e-02 -9.248954e-02
## ASV1461      2.162076e-02  2.188515e-02  2.214162e-02  2.238979e-02
## ASV2877      1.124123e-02  1.131311e-02  1.137268e-02  1.141923e-02
## ASV0012      3.848693e-03  3.973109e-03  4.100422e-03  4.230647e-03
## ASV9823     -6.006522e-03 -6.535664e-03 -7.092999e-03 -7.679227e-03
## ASV0008      3.979886e-03  4.107514e-03  4.238141e-03  4.371786e-03
## ASV7832     -5.576419e-02 -5.767878e-02 -5.964119e-02 -6.165176e-02
## ASV1915     -7.444112e-03 -7.769280e-03 -8.107684e-03 -8.459725e-03
## ASV0055     -8.359329e-03 -8.731678e-03 -9.117934e-03 -9.518461e-03
## ASV0032      3.132730e-04  3.148639e-04  3.188822e-04  3.256844e-04
## ASV2977     -6.731970e-02 -6.925755e-02 -7.122267e-02 -7.321429e-02
## ASV0466      2.753918e-02  2.776483e-02  2.797093e-02  2.815670e-02
## ASV3866      4.921224e-02  5.113368e-02  5.312008e-02  5.517296e-02
## ASV0040      1.476756e-02  1.524699e-02  1.573687e-02  1.623718e-02
## ASV0496     -1.459888e-02 -1.527878e-02 -1.597869e-02 -1.669849e-02
## ASV0052      1.278228e-02  1.322891e-02  1.368893e-02  1.416271e-02
## ASV3828     -2.478823e-02 -2.529194e-02 -2.579905e-02 -2.630956e-02
## ASV1930      1.279185e-02  1.299656e-02  1.319845e-02  1.339733e-02
## ASV2126      3.204858e-02  3.303370e-02  3.404270e-02  3.507598e-02
## ASV0793      5.088465e-02  5.269940e-02  5.456845e-02  5.649327e-02
## ASV0299     -5.234164e-03 -5.620256e-03 -6.030237e-03 -6.465080e-03
## ASV0208      3.529710e-02  3.657561e-02  3.789412e-02  3.925360e-02
## ASV0511     -6.478252e-03 -6.613629e-03 -6.753841e-03 -6.899212e-03
## ASV1123     -1.996076e-02 -2.012582e-02 -2.026959e-02 -2.039040e-02
## ASV0099      3.763797e-03  3.967936e-03  4.180993e-03  4.403180e-03
## ASV0752     -3.093767e-02 -3.215450e-02 -3.341120e-02 -3.470857e-02
## ASV0883      3.829342e-02  3.958237e-02  4.089658e-02  4.223560e-02
## ASV0683      4.969107e-02  5.148235e-02  5.332178e-02  5.520975e-02
## ASV4117     -7.282051e-02 -7.544016e-02 -7.813638e-02 -8.091057e-02
## ASV2172     -2.359264e-03 -2.633953e-03 -2.926015e-03 -3.236111e-03
## ASV0330     -1.439853e-02 -1.494858e-02 -1.551749e-02 -1.610579e-02
## ASV0728      5.557389e-02  5.726699e-02  5.899951e-02  6.077226e-02
## ASV0499      2.035741e-02  2.112089e-02  2.190649e-02  2.271445e-02
## ASV0120     -2.365839e-02 -2.427473e-02 -2.489480e-02 -2.551790e-02
## ASV1446     -1.891304e-03 -2.545012e-03 -3.243633e-03 -3.988821e-03
## ASV17171    -5.455033e-02 -5.649943e-02 -5.850596e-02 -6.057069e-02
## ASV0533      6.087033e-03  6.325731e-03  6.570889e-03  6.822510e-03
## ASV2495     -2.619590e-02 -2.732800e-02 -2.849374e-02 -2.969313e-02
## ASV5582      4.878983e-03  4.573076e-03  4.235795e-03  3.865376e-03
## ASV1488      3.830478e-03  3.763562e-03  3.683862e-03  3.590731e-03
## ASV0682      1.477139e-02  1.529762e-02  1.583615e-02  1.638685e-02
## ASV0068     -1.822709e-02 -1.868795e-02 -1.914984e-02 -1.961219e-02
## ASV1987     -6.791096e-02 -7.047031e-02 -7.310182e-02 -7.580614e-02
## ASV0035     -1.518545e-02 -1.606151e-02 -1.698042e-02 -1.794362e-02
## ASV7192     -2.410369e-02 -2.465595e-02 -2.520830e-02 -2.576016e-02
## ASV0873     -1.024066e-01 -1.071412e-01 -1.120069e-01 -1.170035e-01
## ASV4749     -2.558917e-02 -2.697673e-02 -2.841836e-02 -2.991503e-02
## ASV2174      5.343384e-03  5.137168e-03  4.912106e-03  4.667831e-03
## ASV1476     -3.100654e-02 -3.223695e-02 -3.350656e-02 -3.481613e-02
## ASV0740     -8.386097e-02 -8.718742e-02 -9.062690e-02 -9.418211e-02
## ASV0170     -1.298099e-02 -1.342742e-02 -1.388648e-02 -1.435841e-02
## ASV2466     -6.147797e-02 -6.362837e-02 -6.583667e-02 -6.810335e-02
## ASV1709      2.505490e-02  2.631391e-02  2.764297e-02  2.904560e-02
## ASV6170     -1.051117e-01 -1.088747e-01 -1.127367e-01 -1.166978e-01
## ASV3673      5.517644e-02  5.719807e-02  5.927269e-02  6.140032e-02
## ASV1745     -1.810878e-02 -1.884779e-02 -1.960981e-02 -2.039509e-02
##                                                                    
## (Intercept)  3.148073e-01  3.233631e-01  3.320310e-01  3.408080e-01
## ASV1236      4.853896e-02  4.970392e-02  5.088351e-02  5.207756e-02
## ASV0421      1.724089e-02  1.786048e-02  1.849105e-02  1.913231e-02
## ASV0691     -1.773816e-02 -1.782048e-02 -1.789489e-02 -1.796125e-02
## ASV0899      3.857922e-02  3.938411e-02  4.019710e-02  4.101845e-02
## ASV1004      9.504767e-02  9.721606e-02  9.940662e-02  1.016191e-01
## ASV1041     -2.843423e-02 -2.862922e-02 -2.880100e-02 -2.894876e-02
## ASV1058      6.088586e-02  6.236239e-02  6.385861e-02  6.537437e-02
## ASV12542     2.085281e-02  2.137649e-02  2.191221e-02  2.246028e-02
## ASV1294      5.856929e-02  6.009982e-02  6.166019e-02  6.325089e-02
## ASV13113     4.148370e-02  4.319188e-02  4.495760e-02  4.678192e-02
## ASV1318      5.588647e-02  5.724438e-02  5.862433e-02  6.002669e-02
## ASV2269     -8.581354e-02 -8.740183e-02 -8.898748e-02 -9.056943e-02
## ASV2542      7.945753e-02  8.229369e-02  8.520872e-02  8.820358e-02
## ASV2660     -3.438808e-02 -3.509619e-02 -3.580967e-02 -3.652839e-02
## ASV2737      1.004804e-02  1.028190e-02  1.052116e-02  1.076603e-02
## ASV2840      3.270162e-02  3.301623e-02  3.331881e-02  3.360923e-02
## ASV3053      2.310493e-01  2.361619e-01  2.413333e-01  2.465624e-01
## ASV3077      1.638342e-02  1.681435e-02  1.725432e-02  1.770351e-02
## ASV3134      5.983760e-02  6.220301e-02  6.464433e-02  6.716283e-02
## ASV3140      5.303378e-02  5.451574e-02  5.601972e-02  5.754522e-02
## ASV3579      3.364599e-02  3.490042e-02  3.618333e-02  3.749441e-02
## ASV6119     -2.351418e-02 -2.395393e-02 -2.439287e-02 -2.483059e-02
## ASV7557     -4.780399e-02 -4.869930e-02 -4.959277e-02 -5.048350e-02
## ASV8422      1.303193e-02  1.339542e-02  1.376906e-02  1.415326e-02
## ASV1086     -1.733342e-03 -1.802874e-03 -1.875675e-03 -1.951886e-03
## ASV1310      2.406400e-02  2.454973e-02  2.503582e-02  2.552195e-02
## ASV15750    -6.200994e-04 -5.466112e-04 -4.678338e-04 -3.835561e-04
## ASV16905    -9.844898e-03 -1.002986e-02 -1.021428e-02 -1.039797e-02
## ASV2033      7.794933e-02  8.055299e-02  8.322189e-02  8.595719e-02
## ASV2089      2.078313e-02  2.116947e-02  2.155415e-02  2.193674e-02
## ASV2127      7.512152e-02  7.689942e-02  7.869943e-02  8.052128e-02
## ASV2725      5.100821e-02  5.198835e-02  5.297297e-02  5.396201e-02
## ASV2804     -2.039589e-02 -2.077884e-02 -2.116044e-02 -2.154030e-02
## ASV3075      7.574200e-02  7.845351e-02  8.124582e-02  8.411997e-02
## ASV3327      1.059183e-01  1.093375e-01  1.128370e-01  1.164178e-01
## ASV3342      9.056057e-02  9.357156e-02  9.665842e-02  9.982196e-02
## ASV3532     -9.811759e-02 -1.016106e-01 -1.052152e-01 -1.089342e-01
## ASV3600      4.368560e-02  4.504708e-02  4.643706e-02  4.785552e-02
## ASV4013      6.346607e-02  6.500918e-02  6.656610e-02  6.813619e-02
## ASV4136      5.737664e-02  5.872288e-02  6.008663e-02  6.146776e-02
## ASV4195      2.083723e-01  2.122785e-01  2.161696e-01  2.200419e-01
## ASV4407     -8.052160e-02 -8.202976e-02 -8.353196e-02 -8.502692e-02
## ASV4717      1.081293e-02  1.107944e-02  1.135562e-02  1.164183e-02
## ASV6794      3.339706e-02  3.423897e-02  3.509908e-02  3.597770e-02
## ASV8324     -4.133916e-02 -4.211331e-02 -4.288442e-02 -4.365188e-02
## ASV8981      6.331559e-03  6.693270e-03  7.068070e-03  7.456000e-03
## ASV9859      5.011873e-02  5.251799e-02  5.501554e-02  5.761396e-02
## ASV0936      6.139694e-02  6.310983e-02  6.484666e-02  6.660706e-02
## ASV12683    -6.804069e-05 -9.538400e-06  5.524689e-05  1.265776e-04
## ASV1293      2.770980e-02  2.829818e-02  2.889124e-02  2.948898e-02
## ASV13055     4.484114e-03  4.745099e-03  5.016930e-03  5.299807e-03
## ASV17063    -2.145512e-02 -2.185578e-02 -2.225512e-02 -2.265295e-02
## ASV2228      1.750034e-02  1.782752e-02  1.815376e-02  1.847892e-02
## ASV2769      7.721058e-03  7.952117e-03  8.183963e-03  8.416233e-03
## ASV2803      1.552669e-02  1.582604e-02  1.612966e-02  1.643763e-02
## ASV2896      3.297151e-02  3.436754e-02  3.581926e-02  3.732860e-02
## ASV3062      4.255211e-02  4.407308e-02  4.562878e-02  4.721903e-02
## ASV3107      5.019192e-02  5.191135e-02  5.367467e-02  5.548221e-02
## ASV3265      3.836987e-02  3.914271e-02  3.991854e-02  4.069705e-02
## ASV3666     -1.109899e-03 -1.175786e-03 -1.243643e-03 -1.313476e-03
## ASV4497      1.532644e-02  1.570405e-02  1.608690e-02  1.647491e-02
## ASV6914     -6.199758e-03 -6.430779e-03 -6.667020e-03 -6.908464e-03
## ASV0576     -3.274664e-02 -3.315329e-02 -3.355217e-02 -3.394283e-02
## ASV0673      6.323350e-02  6.491256e-02  6.662319e-02  6.836582e-02
## ASV0772      3.419703e-02  3.526967e-02  3.636954e-02  3.749703e-02
## ASV0862      1.632300e-02  1.691175e-02  1.750786e-02  1.811087e-02
## ASV0898      3.384137e-02  3.493178e-02  3.604683e-02  3.718691e-02
## ASV0910      3.819565e-02  3.949897e-02  4.083532e-02  4.220495e-02
## ASV0964     -1.372978e-02 -1.394917e-02 -1.416878e-02 -1.438857e-02
## ASV10059     3.347840e-02  3.470792e-02  3.596942e-02  3.726299e-02
## ASV10263    -3.271651e-02 -3.333415e-02 -3.395131e-02 -3.456780e-02
## ASV1088      6.986048e-02  7.244271e-02  7.510508e-02  7.784905e-02
## ASV1101      4.690739e-02  4.786260e-02  4.882388e-02  4.979110e-02
## ASV1183      1.957278e-02  2.022356e-02  2.089323e-02  2.158231e-02
## ASV11956     9.736840e-03  9.959788e-03  1.018825e-02  1.042231e-02
## ASV12774    -4.354752e-03 -4.575059e-03 -4.802087e-03 -5.035863e-03
## ASV1321      1.006695e-01  1.039612e-01  1.073205e-01  1.107468e-01
## ASV13793    -2.257360e-02 -2.300278e-02 -2.343221e-02 -2.386180e-02
## ASV14482     1.939154e-03  2.033255e-03  2.131394e-03  2.233619e-03
## ASV15483     1.524537e-02  1.572352e-02  1.621269e-02  1.671305e-02
## ASV2062      5.741878e-02  5.903271e-02  6.067669e-02  6.235064e-02
## ASV2132      5.718936e-02  5.891714e-02  6.067601e-02  6.246569e-02
## ASV2413      4.022220e-02  4.131748e-02  4.243627e-02  4.357904e-02
## ASV2490      9.377795e-02  9.556598e-02  9.736326e-02  9.916964e-02
## ASV2594      2.483098e-02  2.581454e-02  2.683273e-02  2.788637e-02
## ASV2822     -5.961411e-02 -6.075697e-02 -6.190173e-02 -6.304810e-02
## ASV2863      6.649581e-02  6.803055e-02  6.958547e-02  7.116065e-02
## ASV2910      2.518357e-02  2.579151e-02  2.640971e-02  2.703841e-02
## ASV2980      3.333211e-02  3.422024e-02  3.512346e-02  3.604181e-02
## ASV3307      4.749448e-02  4.841301e-02  4.933396e-02  5.025709e-02
## ASV3474      6.173166e-02  6.384330e-02  6.600367e-02  6.821283e-02
## ASV3502      5.042202e-02  5.205803e-02  5.373867e-02  5.546490e-02
## ASV4236      3.976810e-02  4.040293e-02  4.103611e-02  4.166746e-02
## ASV4842     -3.458062e-03 -3.378963e-03 -3.290115e-03 -3.191252e-03
## ASV4894     -2.264517e-02 -2.308602e-02 -2.352824e-02 -2.397171e-02
## ASV5290      2.839871e-02  2.930422e-02  3.023361e-02  3.118746e-02
## ASV5501      2.208131e-02  2.301350e-02  2.398179e-02  2.498720e-02
## ASV5795      1.943561e-02  2.001362e-02  2.060104e-02  2.119769e-02
## ASV5987     -6.332163e-02 -6.456253e-02 -6.580785e-02 -6.705720e-02
## ASV6267     -7.139265e-02 -7.279580e-02 -7.420424e-02 -7.561756e-02
## ASV6862      2.825347e-02  2.889561e-02  2.954668e-02  3.020672e-02
## ASV7145      1.473948e-02  1.520046e-02  1.567418e-02  1.616086e-02
## ASV7673     -2.270528e-02 -2.315338e-02 -2.360326e-02 -2.405481e-02
## ASV7789      3.341849e-02  3.483787e-02  3.630479e-02  3.782014e-02
## ASV7809      6.815535e-03  7.095377e-03  7.381216e-03  7.672952e-03
## ASV8002     -2.872140e-02 -2.929229e-02 -2.986573e-02 -3.044156e-02
## ASV8205      1.952900e-02  2.014571e-02  2.077476e-02  2.141605e-02
## ASV9155     -5.144308e-03 -5.179765e-03 -5.212059e-03 -5.241091e-03
## ASV9221      1.724167e-02  1.807965e-02  1.895068e-02  1.985576e-02
## ASV9311     -4.618031e-02 -4.710607e-02 -4.803631e-02 -4.897079e-02
## ASV9557     -3.158355e-02 -3.221802e-02 -3.285560e-02 -3.349614e-02
## ASV9936     -6.373857e-02 -6.502154e-02 -6.631088e-02 -6.760629e-02
## ASV1445      5.980157e-02  6.159366e-02  6.341794e-02  6.527397e-02
## ASV4232      3.993966e-02  4.178595e-02  4.370827e-02  4.570876e-02
## ASV6479      2.611515e-02  2.736854e-02  2.866863e-02  3.001632e-02
## ASV0142     -2.821494e-02 -2.885230e-02 -2.949773e-02 -3.015130e-02
## ASV0378      2.464414e-02  2.540816e-02  2.618186e-02  2.696461e-02
## ASV1122      6.286611e-02  6.492465e-02  6.703209e-02  6.918873e-02
## ASV0123     -2.423480e-02 -2.475422e-02 -2.527838e-02 -2.580725e-02
## ASV2064      3.350086e-03  3.087463e-03  2.804331e-03  2.500194e-03
## ASV4459     -1.700956e-03 -1.830449e-03 -1.969719e-03 -2.119118e-03
## ASV0448      2.101427e-02  2.174377e-02  2.248859e-02  2.324838e-02
## ASV0397      2.942633e-02  3.023155e-02  3.105056e-02  3.188340e-02
## ASV0485      3.191779e-02  3.276647e-02  3.362871e-02  3.450438e-02
## ASV1566      4.965301e-02  5.099054e-02  5.234863e-02  5.372700e-02
## ASV1365      4.324107e-02  4.433835e-02  4.544925e-02  4.657388e-02
## ASV1065      6.581420e-02  6.770199e-02  6.962284e-02  7.157662e-02
## ASV0722     -6.790335e-03 -7.120396e-03 -7.464803e-03 -7.823980e-03
## ASV12660    -2.531130e-02 -2.582921e-02 -2.635098e-02 -2.687659e-02
## ASV0223      1.000553e-02  1.032556e-02  1.065395e-02  1.099077e-02
## ASV0229      1.950270e-02  2.021385e-02  2.094779e-02  2.170513e-02
## ASV0877     -6.280334e-03 -6.954257e-03 -7.670920e-03 -8.431950e-03
## ASV0983      2.810023e-02  2.872049e-02  2.934421e-02  2.997111e-02
## ASV0626      1.261072e-02  1.310701e-02  1.361597e-02  1.413766e-02
## ASV4146     -6.364162e-03 -6.930895e-03 -7.530722e-03 -8.164436e-03
## ASV4175     -4.891023e-02 -5.035419e-02 -5.182230e-02 -5.331427e-02
## ASV2082     -5.285506e-02 -5.523034e-02 -5.768439e-02 -6.021787e-02
## ASV2272      2.548172e-02  2.636564e-02  2.727435e-02  2.820828e-02
## ASV2245     -3.607567e-02 -3.715280e-02 -3.824794e-02 -3.936086e-02
## ASV0590     -5.480341e-02 -5.730441e-02 -5.989215e-02 -6.256781e-02
## ASV0217      1.668970e-02  1.748066e-02  1.829946e-02  1.914679e-02
## ASV0416      4.754711e-03  4.478559e-03  4.182503e-03  3.866242e-03
## ASV1056      3.824959e-02  3.944144e-02  4.065445e-02  4.188826e-02
## ASV7777     -5.310400e-02 -5.513329e-02 -5.724200e-02 -5.943367e-02
## ASV0455      6.723073e-03  6.852119e-03  6.978418e-03  7.101606e-03
## ASV0604      2.797533e-02  2.893361e-02  2.991432e-02  3.091742e-02
## ASV6100     -4.073659e-02 -4.233874e-02 -4.399961e-02 -4.572109e-02
## ASV11359    -6.510155e-02 -6.683850e-02 -6.859428e-02 -7.036820e-02
## ASV6604      1.124460e-02  1.155501e-02  1.186501e-02  1.217389e-02
## ASV5004     -2.549252e-02 -2.635702e-02 -2.724562e-02 -2.815861e-02
## ASV1483     -8.954829e-03 -9.166347e-03 -9.377681e-03 -9.588522e-03
## ASV9773     -3.543776e-02 -3.669328e-02 -3.798644e-02 -3.931801e-02
## ASV4059      1.125094e-02  1.170588e-02  1.216397e-02  1.262407e-02
## ASV1193      3.426541e-02  3.524623e-02  3.624448e-02  3.725999e-02
## ASV4610      4.849762e-03  5.034720e-03  5.216234e-03  5.393636e-03
## ASV0742      7.154682e-03  7.471974e-03  7.793825e-03  8.119965e-03
## ASV1502     -9.056877e-03 -9.408184e-03 -9.764953e-03 -1.012684e-02
## ASV0195     -3.771479e-03 -3.967086e-03 -4.169573e-03 -4.379092e-03
## ASV1213      1.180329e-02  1.189007e-02  1.196915e-02  1.204018e-02
## ASV1648     -3.730722e-02 -3.879938e-02 -4.034538e-02 -4.194656e-02
## ASV6984     -3.589842e-02 -3.735868e-02 -3.887261e-02 -4.044162e-02
## ASV0396     -1.561142e-04 -3.180364e-04 -5.012974e-04 -7.074515e-04
## ASV4297      2.192337e-02  2.234950e-02  2.278201e-02  2.322128e-02
## ASV2622      4.378513e-02  4.485544e-02  4.594122e-02  4.704250e-02
## ASV3512      4.811786e-02  5.033106e-02  5.263100e-02  5.501998e-02
## ASV2411      5.088317e-02  5.256299e-02  5.427386e-02  5.601496e-02
## ASV2291     -4.581573e-02 -4.776174e-02 -4.976566e-02 -5.182796e-02
## ASV0807      4.742195e-02  4.867490e-02  4.994943e-02  5.124604e-02
## ASV1292      5.302354e-03  5.416217e-03  5.538365e-03  5.669530e-03
## ASV1035      3.771861e-02  3.874201e-02  3.978910e-02  4.086051e-02
## ASV0070      7.322286e-03  7.700136e-03  8.091785e-03  8.497419e-03
## ASV0255     -2.076183e-03 -2.384482e-03 -2.713752e-03 -3.064772e-03
## ASV0057     -5.212984e-03 -5.190353e-03 -5.160864e-03 -5.124391e-03
## ASV0077     -5.869583e-06 -1.286485e-05 -2.576790e-05 -4.527712e-05
## ASV0625      1.719780e-02  1.750925e-02  1.782149e-02  1.813452e-02
## ASV2464      1.230041e-01  1.255056e-01  1.280240e-01  1.305588e-01
## ASV1315      6.887069e-02  7.122752e-02  7.363499e-02  7.609252e-02
## ASV2673      6.088898e-02  6.307492e-02  6.531723e-02  6.761612e-02
## ASV2161      2.725991e-02  2.832453e-02  2.942237e-02  3.055387e-02
## ASV0337     -1.208125e-02 -1.248609e-02 -1.290118e-02 -1.332658e-02
## ASV7680     -8.070062e-02 -8.331854e-02 -8.599105e-02 -8.871763e-02
## ASV0611      4.800433e-02  4.972833e-02  5.150335e-02  5.333041e-02
## ASV3118     -5.672544e-02 -5.874158e-02 -6.080831e-02 -6.292599e-02
## ASV1284     -3.431826e-02 -3.670210e-02 -3.920500e-02 -4.183062e-02
## ASV0889      2.690234e-02  2.779940e-02  2.872723e-02  2.968693e-02
## ASV4649     -1.573872e-02 -1.625168e-02 -1.677743e-02 -1.731612e-02
## ASV1108     -4.880869e-02 -5.068619e-02 -5.261675e-02 -5.460086e-02
## ASV0738      3.947687e-02  4.131352e-02  4.322372e-02  4.520972e-02
## ASV0473     -5.595856e-03 -5.617721e-03 -5.621096e-03 -5.604270e-03
## ASV0598     -2.487552e-02 -2.606051e-02 -2.728929e-02 -2.856259e-02
## ASV0429      1.224601e-02  1.239468e-02  1.253945e-02  1.268040e-02
## ASV1549      5.584385e-02  5.775196e-02  5.969743e-02  6.167920e-02
## ASV1203      2.527511e-02  2.585700e-02  2.644249e-02  2.703129e-02
## ASV4532      1.390655e-03  1.532700e-03  1.687268e-03  1.855035e-03
## ASV0274      6.762502e-03  6.878438e-03  6.986810e-03  7.086852e-03
## ASV0163     -1.720677e-02 -1.767930e-02 -1.816593e-02 -1.866725e-02
## ASV1298      5.114985e-03  5.506144e-03  5.923821e-03  6.369166e-03
## ASV9424     -7.128423e-02 -7.399301e-02 -7.678918e-02 -7.967457e-02
## ASV0412      4.328760e-02  4.435688e-02  4.544223e-02  4.654392e-02
## ASV0284     -2.237802e-03 -2.691239e-03 -3.175176e-03 -3.690848e-03
## ASV0620     -2.442709e-02 -2.544695e-02 -2.649912e-02 -2.758411e-02
## ASV0153     -7.220351e-02 -7.462113e-02 -7.708755e-02 -7.960207e-02
## ASV0498      1.745658e-02  1.780064e-02  1.813820e-02  1.846855e-02
## ASV0097      1.466946e-02  1.516948e-02  1.567919e-02  1.619834e-02
## ASV0104     -6.284844e-02 -6.436118e-02 -6.588688e-02 -6.742496e-02
## ASV1282      9.248482e-03  8.998248e-03  8.714855e-03  8.397001e-03
## ASV3883     -3.224609e-02 -3.330128e-02 -3.436995e-02 -3.545094e-02
## ASV0801      1.383712e-02  1.443050e-02  1.504925e-02  1.569425e-02
## ASV1611     -6.430553e-02 -6.659049e-02 -6.893394e-02 -7.133614e-02
## ASV0227     -2.154127e-02 -2.247803e-02 -2.344694e-02 -2.444876e-02
## ASV0833      1.727271e-02  1.779449e-02  1.832678e-02  1.886960e-02
## ASV0718      7.858614e-02  8.101229e-02  8.348725e-02  8.601089e-02
## ASV1139     -7.922097e-03 -8.542270e-03 -9.188124e-03 -9.859868e-03
## ASV0766     -1.633717e-02 -1.689071e-02 -1.745395e-02 -1.802662e-02
## ASV2091      3.407805e-02  3.457464e-02  3.506429e-02  3.554683e-02
## ASV1238     -8.126515e-02 -8.472880e-02 -8.832677e-02 -9.206284e-02
## ASV9193     -2.475463e-02 -2.602873e-02 -2.735319e-02 -2.872894e-02
## ASV0290      3.098050e-03  3.238859e-03  3.390720e-03  3.554108e-03
## ASV0231      1.479197e-02  1.501290e-02  1.522611e-02  1.543109e-02
## ASV0185      2.926364e-02  3.058012e-02  3.194489e-02  3.335907e-02
## ASV2330      1.360665e-02  1.387482e-02  1.414810e-02  1.442665e-02
## ASV3119     -2.481822e-02 -2.589638e-02 -2.701142e-02 -2.816398e-02
## ASV2368     -4.738919e-02 -4.943928e-02 -5.156466e-02 -5.376692e-02
## ASV0122     -1.158127e-02 -1.189780e-02 -1.222088e-02 -1.255069e-02
## ASV1044      4.772633e-02  4.952409e-02  5.137743e-02  5.328738e-02
## ASV0160     -9.180382e-03 -9.437073e-03 -9.703847e-03 -9.981206e-03
## ASV0326      2.774499e-03  2.786302e-03  2.792921e-03  2.794001e-03
## ASV1388      5.877976e-02  6.023828e-02  6.171427e-02  6.320759e-02
## ASV0792      3.497397e-02  3.566264e-02  3.635409e-02  3.704830e-02
## ASV0036     -2.035686e-02 -2.096447e-02 -2.157825e-02 -2.219758e-02
## ASV2125      4.393650e-02  4.501816e-02  4.610778e-02  4.720463e-02
## ASV1075     -2.434165e-03 -2.588344e-03 -2.750673e-03 -2.921393e-03
## ASV0390      4.230077e-02  4.404594e-02  4.585178e-02  4.771951e-02
## ASV3790     -4.481744e-02 -4.633072e-02 -4.788209e-02 -4.947188e-02
## ASV1535     -2.090534e-02 -2.169816e-02 -2.250986e-02 -2.334038e-02
## ASV0263      4.749337e-02  4.890994e-02  5.035333e-02  5.182348e-02
## ASV0675      8.726457e-02  9.024767e-02  9.330361e-02  9.643271e-02
## ASV3348      8.742535e-03  9.029220e-03  9.319261e-03  9.612235e-03
## ASV0058     -1.661257e-02 -1.699431e-02 -1.737848e-02 -1.776487e-02
## ASV4142      1.933351e-02  1.976570e-02  2.020546e-02  2.065308e-02
## ASV0059     -1.244386e-02 -1.271196e-02 -1.298177e-02 -1.325326e-02
## ASV0013     -2.924170e-02 -3.009868e-02 -3.097276e-02 -3.186409e-02
## ASV0033     -1.778983e-02 -1.834288e-02 -1.890408e-02 -1.947309e-02
## ASV4354     -2.038010e-02 -2.106614e-02 -2.176725e-02 -2.248330e-02
## ASV0022     -1.533756e-02 -1.582852e-02 -1.632728e-02 -1.683349e-02
## ASV0134     -2.138125e-02 -2.235917e-02 -2.337859e-02 -2.444099e-02
## ASV0415      3.524633e-03  3.636704e-03  3.750828e-03  3.867068e-03
## ASV10103    -8.289556e-02 -8.569259e-02 -8.855217e-02 -9.147402e-02
## ASV1613      2.963346e-02  2.998924e-02  3.032893e-02  3.065192e-02
## ASV0135     -2.305020e-03 -2.287446e-03 -2.266347e-03 -2.241649e-03
## ASV0469     -5.656943e-02 -5.823881e-02 -5.994763e-02 -6.169657e-02
## ASV0471      3.993977e-02  4.127764e-02  4.265739e-02  4.408039e-02
## ASV0451     -1.676306e-02 -1.744109e-02 -1.813647e-02 -1.884920e-02
## ASV0747      2.205912e-02  2.264443e-02  2.323484e-02  2.383001e-02
## ASV1314     -3.571449e-02 -3.718061e-02 -3.869645e-02 -4.026299e-02
## ASV0425     -5.251084e-02 -5.362178e-02 -5.474320e-02 -5.587504e-02
## ASV0559     -2.452289e-02 -2.551849e-02 -2.654953e-02 -2.761659e-02
## ASV0148      5.353091e-03  5.785472e-03  6.240865e-03  6.720094e-03
## ASV0129      2.276806e-02  2.391975e-02  2.511544e-02  2.635591e-02
## ASV1072     -1.258245e-03 -1.450632e-03 -1.652005e-03 -1.862352e-03
## ASV2390      1.492365e-02  1.478807e-02  1.462915e-02  1.444651e-02
## ASV0548      2.409187e-02  2.473278e-02  2.538343e-02  2.604385e-02
## ASV0168     -1.123324e-02 -1.153088e-02 -1.183401e-02 -1.214270e-02
## ASV0066     -1.135380e-02 -1.154409e-02 -1.172909e-02 -1.190829e-02
## ASV0468     -9.736991e-03 -1.010237e-02 -1.048041e-02 -1.087145e-02
## ASV0172      1.027940e-03  1.204364e-03  1.391051e-03  1.588289e-03
## ASV0236      1.854366e-02  1.949902e-02  2.048604e-02  2.150481e-02
## ASV0250      4.389317e-02  4.584073e-02  4.786033e-02  4.995361e-02
## ASV0338      1.046253e-02  1.067790e-02  1.088882e-02  1.109469e-02
## ASV0450     -6.842167e-03 -7.168599e-03 -7.506015e-03 -7.854411e-03
## ASV0377      1.418055e-02  1.441837e-02  1.464934e-02  1.487279e-02
## ASV1022      2.562635e-03  2.795017e-03  3.042911e-03  3.307022e-03
## ASV6174     -2.142931e-03 -2.140219e-03 -2.124628e-03 -2.094807e-03
## ASV0786     -7.845056e-03 -8.090328e-03 -8.334312e-03 -8.576315e-03
## ASV0053     -2.103022e-02 -2.164267e-02 -2.226636e-02 -2.290135e-02
## ASV0697     -1.041378e-02 -1.075169e-02 -1.110368e-02 -1.147066e-02
## ASV0785      2.240802e-02  2.302157e-02  2.365004e-02  2.429410e-02
## ASV1967     -2.223841e-02 -2.281665e-02 -2.340191e-02 -2.399392e-02
## ASV0385      1.021071e-02  1.043360e-02  1.065152e-02  1.086382e-02
## ASV0295      8.731265e-03  9.180387e-03  9.647407e-03  1.013273e-02
## ASV0072     -1.251364e-02 -1.264999e-02 -1.277796e-02 -1.289722e-02
## ASV0157      9.173970e-03  9.792287e-03  1.044092e-02  1.112078e-02
## ASV0501      4.420378e-02  4.535152e-02  4.650921e-02  4.767640e-02
## ASV10729    -6.510666e-02 -6.722697e-02 -6.939613e-02 -7.161452e-02
## ASV1470      9.709666e-03  9.503206e-03  9.268393e-03  9.004094e-03
## ASV0050     -3.968958e-02 -4.061349e-02 -4.154374e-02 -4.247995e-02
## ASV0411     -1.604973e-02 -1.671441e-02 -1.740559e-02 -1.812427e-02
## ASV0549      2.101343e-02  2.168280e-02  2.236473e-02  2.305895e-02
## ASV0184      7.186878e-03  7.495536e-03  7.818542e-03  8.156581e-03
## ASV0705      6.332658e-03  6.335531e-03  6.326932e-03  6.306149e-03
## ASV1715      2.480646e-02  2.552392e-02  2.625405e-02  2.699683e-02
## ASV0603      8.231749e-03  8.665240e-03  9.119031e-03  9.593678e-03
## ASV0826      3.911612e-02  4.026322e-02  4.143548e-02  4.263325e-02
## ASV0034     -9.259090e-03 -9.433522e-03 -9.607588e-03 -9.781242e-03
## ASV0838     -2.308978e-02 -2.488736e-02 -2.678638e-02 -2.879036e-02
## ASV0614     -1.051199e-02 -1.081471e-02 -1.112416e-02 -1.144049e-02
## ASV0014     -2.778322e-02 -2.852398e-02 -2.927472e-02 -3.003526e-02
## ASV0585     -1.050851e-02 -1.100631e-02 -1.151242e-02 -1.202619e-02
## ASV0016     -2.914126e-02 -2.992407e-02 -3.071795e-02 -3.152276e-02
## ASV5394     -2.365333e-02 -2.423635e-02 -2.481573e-02 -2.538991e-02
## ASV0666      3.514933e-02  3.586962e-02  3.659511e-02  3.732583e-02
## ASV2085     -1.440497e-02 -1.545929e-02 -1.656432e-02 -1.772164e-02
## ASV0003     -1.986878e-02 -2.040849e-02 -2.095658e-02 -2.151302e-02
## ASV0346      1.304319e-02  1.340491e-02  1.376925e-02  1.413592e-02
## ASV0267      2.592754e-03  2.587099e-03  2.567405e-03  2.532307e-03
## ASV0353      2.226924e-02  2.303047e-02  2.380912e-02  2.460509e-02
## ASV2419      3.837530e-02  3.921819e-02  4.005641e-02  4.088843e-02
## ASV0447      3.279483e-02  3.394726e-02  3.513179e-02  3.634902e-02
## ASV0654      3.398865e-02  3.486810e-02  3.575863e-02  3.666013e-02
## ASV0151      1.155890e-02  1.203070e-02  1.251460e-02  1.301048e-02
## ASV0065     -1.230848e-02 -1.262553e-02 -1.294757e-02 -1.327466e-02
## ASV0527      3.212222e-02  3.295014e-02  3.378568e-02  3.462821e-02
## ASV4055     -1.574211e-02 -1.666185e-02 -1.763351e-02 -1.865964e-02
## ASV0166     -1.220210e-02 -1.246904e-02 -1.274075e-02 -1.301752e-02
## ASV0417     -1.938426e-03 -1.900668e-03 -1.861525e-03 -1.821392e-03
## ASV0078     -5.980787e-03 -5.998169e-03 -6.006328e-03 -6.004721e-03
## ASV0322      8.455767e-03  9.037135e-03  9.645881e-03  1.028260e-02
## ASV0156     -3.129660e-02 -3.244331e-02 -3.362717e-02 -3.484924e-02
## ASV0648     -6.552872e-02 -6.763129e-02 -6.977188e-02 -7.194932e-02
## ASV0407     -7.156978e-03 -7.470085e-03 -7.795032e-03 -8.132116e-03
## ASV2030     -1.422583e-02 -1.489568e-02 -1.559217e-02 -1.631575e-02
## ASV0300      8.746528e-03  9.026290e-03  9.310388e-03  9.598632e-03
## ASV1150      2.559053e-03  2.615876e-03  2.670091e-03  2.721354e-03
## ASV0958      3.285089e-02  3.419288e-02  3.557994e-02  3.701298e-02
## ASV0216     -2.428217e-02 -2.522083e-02 -2.619546e-02 -2.720716e-02
## ASV0446      3.841644e-02  3.958573e-02  4.077496e-02  4.198381e-02
## ASV0367     -2.391354e-02 -2.464835e-02 -2.539706e-02 -2.615950e-02
## ASV0200     -1.274577e-02 -1.305410e-02 -1.336118e-02 -1.366636e-02
## ASV0334     -2.087478e-03 -2.163750e-03 -2.249393e-03 -2.345203e-03
## ASV1311      8.480640e-05 -1.349577e-04 -3.696705e-04 -6.198532e-04
## ASV0458      1.337213e-03  1.147367e-03  9.459028e-04  7.326570e-04
## ASV1371      2.243546e-03  2.262882e-03  2.278474e-03  2.290118e-03
## ASV0418      1.950917e-02  1.990555e-02  2.030540e-02  2.070896e-02
## ASV0004      2.514874e-03  2.555511e-03  2.595798e-03  2.635706e-03
## ASV1943      1.999023e-02  1.973171e-02  1.945155e-02  1.914989e-02
## ASV1495     -2.320491e-02 -2.432737e-02 -2.548934e-02 -2.669121e-02
## ASV0901     -3.527990e-02 -3.668349e-02 -3.813588e-02 -3.963825e-02
## ASV0628      3.217445e-03  3.035873e-03  2.835847e-03  2.616495e-03
## ASV0400      3.130754e-03  3.022047e-03  2.897179e-03  2.755213e-03
## ASV0116     -9.705215e-03 -1.006356e-02 -1.043262e-02 -1.081258e-02
## ASV0788      8.990124e-02  9.342521e-02  9.707405e-02  1.008518e-01
## ASV0117      7.525673e-03  7.811873e-03  8.106818e-03  8.410752e-03
## ASV3137     -4.933919e-04 -4.493171e-04 -3.989076e-04 -3.416737e-04
## ASV0001      2.536331e-03  2.581459e-03  2.627538e-03  2.674683e-03
## ASV1651      8.758452e-03  8.975302e-03  9.199129e-03  9.430481e-03
## ASV1692      7.081772e-02  7.345308e-02  7.617464e-02  7.898497e-02
## ASV0660      1.464155e-03  1.053640e-03  6.166433e-04  1.527480e-04
## ASV0508     -2.732334e-04 -3.363050e-04 -4.053607e-04 -4.808140e-04
## ASV1660     -1.727664e-02 -1.783163e-02 -1.839224e-02 -1.895776e-02
## ASV0233      1.782599e-02  1.839441e-02  1.897707e-02  1.957427e-02
## ASV1343     -4.015604e-02 -4.165425e-02 -4.319988e-02 -4.479401e-02
## ASV0209      7.627737e-03  7.660175e-03  7.683696e-03  7.697861e-03
## ASV0193     -9.040900e-03 -9.063049e-03 -9.073484e-03 -9.071697e-03
## ASV0357      1.928179e-02  2.024658e-02  2.125114e-02  2.229636e-02
## ASV0198      1.254066e-02  1.293523e-02  1.334074e-02  1.375745e-02
## ASV0007      1.711473e-03  1.727183e-03  1.743153e-03  1.759498e-03
## ASV1772      9.565916e-03  1.061541e-02  1.174619e-02  1.296302e-02
## ASV0009      1.016873e-03  1.016192e-03  1.015924e-03  1.016229e-03
## ASV0006     -5.487651e-03 -5.684556e-03 -5.886106e-03 -6.092286e-03
## ASV0011     -1.505789e-02 -1.556507e-02 -1.608494e-02 -1.661761e-02
## ASV0015      4.075627e-04  3.714569e-04  3.325495e-04  2.907459e-04
## ASV0017      7.316738e-04  7.104018e-04  6.870522e-04  6.615583e-04
## ASV0235     -1.483259e-02 -1.537753e-02 -1.594015e-02 -1.652096e-02
## ASV0382      6.002358e-03  5.938453e-03  5.854025e-03  5.747803e-03
## ASV2357      4.640175e-02  4.798919e-02  4.961363e-02  5.127467e-02
## ASV0567     -1.240575e-02 -1.297916e-02 -1.357672e-02 -1.419912e-02
## ASV0165      6.856002e-03  7.059930e-03  7.267780e-03  7.479599e-03
## ASV0005      7.982474e-03  8.171772e-03  8.361989e-03  8.552990e-03
## ASV0384      5.292200e-03  5.651679e-03  6.030194e-03  6.428457e-03
## ASV0002      1.371924e-03  1.408615e-03  1.445854e-03  1.483625e-03
## ASV3017      2.912342e-02  2.955691e-02  2.998392e-02  3.040429e-02
## ASV0091     -2.270507e-03 -2.409399e-03 -2.556919e-03 -2.713494e-03
## ASV0186     -1.627192e-02 -1.663282e-02 -1.699297e-02 -1.735203e-02
## ASV0370      8.437344e-03  8.692739e-03  8.956592e-03  9.229328e-03
## ASV0018      1.079930e-02  1.107832e-02  1.136046e-02  1.164564e-02
## ASV1377      8.151365e-02  8.315412e-02  8.480340e-02  8.646173e-02
## ASV0019      1.158876e-02  1.189892e-02  1.221334e-02  1.253197e-02
## ASV0023     -9.069982e-03 -9.342187e-03 -9.618233e-03 -9.897974e-03
## ASV2194      1.921470e-02  1.998547e-02  2.078130e-02  2.160256e-02
## ASV1155      4.197257e-02  4.326825e-02  4.460382e-02  4.598080e-02
## ASV0510     -6.490834e-03 -6.639152e-03 -6.792009e-03 -6.949410e-03
## ASV2371     -2.199166e-02 -2.247084e-02 -2.295188e-02 -2.343457e-02
## ASV0024     -1.118069e-02 -1.152013e-02 -1.186493e-02 -1.221495e-02
## ASV2452      1.079642e-02  1.071907e-02  1.062769e-02  1.052213e-02
## ASV2332     -7.502162e-02 -7.717404e-02 -7.937013e-02 -8.161000e-02
## ASV2591      3.347056e-02  3.444962e-02  3.543821e-02  3.643570e-02
## ASV0521      2.445031e-02  2.530510e-02  2.618323e-02  2.708506e-02
## ASV5542      2.135626e-02  2.204567e-02  2.275167e-02  2.347446e-02
## ASV0336     -7.970664e-03 -8.372005e-03 -8.792624e-03 -9.233475e-03
## ASV10102     3.859706e-02  3.974411e-02  4.091013e-02  4.209490e-02
## ASV16823    -3.314881e-02 -3.382853e-02 -3.451466e-02 -3.520726e-02
## ASV3104      1.714969e-01  1.750125e-01  1.785611e-01  1.821432e-01
## ASV0781      3.934690e-02  4.062776e-02  4.194374e-02  4.329551e-02
## ASV10899     4.900857e-02  5.111509e-02  5.329337e-02  5.554476e-02
## ASV11222    -5.833019e-02 -5.952553e-02 -6.073212e-02 -6.195008e-02
## ASV11327    -5.236465e-02 -5.343754e-02 -5.452053e-02 -5.561371e-02
## ASV12458    -5.831843e-02 -5.951313e-02 -6.071908e-02 -6.193638e-02
## ASV1636      4.147758e-02  4.251397e-02  4.356732e-02  4.463793e-02
## ASV1890     -2.026751e-02 -2.067802e-02 -2.110311e-02 -2.154385e-02
## ASV2898      5.647313e-02  5.793006e-02  5.941512e-02  6.092900e-02
## ASV8328      4.842557e-02  5.074079e-02  5.313235e-02  5.560060e-02
## ASV0709     -6.741896e-02 -6.910826e-02 -7.081772e-02 -7.254694e-02
## ASV0856      8.659110e-02  8.948102e-02  9.243131e-02  9.544141e-02
## ASV0909      5.063807e-02  5.280943e-02  5.504843e-02  5.735590e-02
## ASV0937     -6.465477e-02 -6.719576e-02 -6.981903e-02 -7.252567e-02
## ASV11390    -8.321395e-02 -8.491827e-02 -8.663868e-02 -8.837537e-02
## ASV11966     4.582965e-02  4.734511e-02  4.888914e-02  5.046127e-02
## ASV12990     1.662625e-02  1.701859e-02  1.741604e-02  1.781841e-02
## ASV14797     2.343657e-02  2.397591e-02  2.452338e-02  2.507900e-02
## ASV14904    -1.193967e-01 -1.218420e-01 -1.243104e-01 -1.268022e-01
## ASV15304     3.411629e-02  3.529724e-02  3.650125e-02  3.772791e-02
## ASV16696    -4.125232e-02 -4.209726e-02 -4.295023e-02 -4.381131e-02
## ASV1690      1.312434e-01  1.349614e-01  1.387201e-01  1.425172e-01
## ASV2029      6.993423e-02  7.189152e-02  7.388489e-02  7.591438e-02
## ASV2834      1.032188e-01  1.061878e-01  1.092025e-01  1.122620e-01
## ASV4003      1.491669e-01  1.559256e-01  1.629622e-01  1.702860e-01
## ASV4064      5.335680e-02  5.510357e-02  5.689535e-02  5.873304e-02
## ASV4294      5.703023e-02  5.946634e-02  6.198505e-02  6.458783e-02
## ASV4609      2.556018e-02  2.639499e-02  2.725195e-02  2.813124e-02
## ASV6283     -3.855980e-02 -3.934971e-02 -4.014714e-02 -4.095219e-02
## ASV6491     -5.526813e-02 -5.640050e-02 -5.754368e-02 -5.869780e-02
## ASV7453      6.369264e-02  6.586201e-02  6.807575e-02  7.033342e-02
## ASV7959      3.998846e-02  4.179598e-02  4.367077e-02  4.561455e-02
## ASV8219      4.776501e-01  4.874402e-01  4.973241e-01  5.073029e-01
## ASV8547     -4.948466e-02 -5.049916e-02 -5.152341e-02 -5.255751e-02
## ASV9319      4.912523e-02  5.103535e-02  5.300935e-02  5.504880e-02
## ASV9382     -9.682726e-02 -9.881294e-02 -1.008177e-01 -1.028419e-01
## ASV11516    -6.467584e-02 -6.600256e-02 -6.734209e-02 -6.869457e-02
## ASV14377    -4.670191e-02 -4.766021e-02 -4.862779e-02 -4.960474e-02
## ASV1867      7.066293e-02  7.314364e-02  7.569691e-02  7.832425e-02
## ASV1895      7.137095e-03  6.819002e-03  6.474505e-03  6.103154e-03
## ASV3168      2.033031e-02  2.059782e-02  2.085952e-02  2.111515e-02
## ASV4449      2.146955e-01  2.218759e-01  2.292587e-01  2.368484e-01
## ASV6596      7.840694e-02  8.166700e-02  8.502994e-02  8.849663e-02
## ASV7492      1.765529e-02  1.863804e-02  1.965181e-02  2.069633e-02
## ASV9854     -9.163734e-03 -9.331783e-03 -9.500993e-03 -9.671487e-03
## ASV6296      7.838271e-01  7.999260e-01  8.161820e-01  8.325968e-01
## ASV4201      3.999594e-02  4.209710e-02  4.428813e-02  4.657181e-02
## ASV0552      4.354585e-02  4.479274e-02  4.605414e-02  4.732909e-02
## ASV3671     -3.454659e-02 -3.604664e-02 -3.760851e-02 -3.923390e-02
## ASV3529      7.171061e-03  7.484724e-03  7.799698e-03  8.115379e-03
## ASV1060      1.898571e-02  1.985459e-02  2.075979e-02  2.170249e-02
## ASV0239     -6.354840e-03 -6.377504e-03 -6.393194e-03 -6.401474e-03
## ASV5711     -5.700937e-02 -5.855827e-02 -6.013064e-02 -6.172606e-02
## ASV4152     -9.516871e-02 -9.788705e-02 -1.006435e-01 -1.034371e-01
## ASV1461      2.262930e-02  2.285977e-02  2.308081e-02  2.329203e-02
## ASV2877      1.145201e-02  1.147025e-02  1.147317e-02  1.145998e-02
## ASV0012      4.363800e-03  4.499896e-03  4.638948e-03  4.780972e-03
## ASV9823     -8.295023e-03 -8.941027e-03 -9.617849e-03 -1.032606e-02
## ASV0008      4.508468e-03  4.648203e-03  4.791008e-03  4.936898e-03
## ASV7832     -6.371082e-02 -6.581867e-02 -6.797560e-02 -7.018189e-02
## ASV1915     -8.825810e-03 -9.206354e-03 -9.601784e-03 -1.001254e-02
## ASV0055     -9.933625e-03 -1.036379e-02 -1.080934e-02 -1.127063e-02
## ASV0032      3.356487e-04  3.491746e-04  3.666833e-04  3.886165e-04
## ASV2977     -7.523166e-02 -7.727399e-02 -7.934053e-02 -8.143054e-02
## ASV0466      2.832134e-02  2.846405e-02  2.858405e-02  2.868052e-02
## ASV3866      5.729387e-02  5.948433e-02  6.174584e-02  6.407989e-02
## ASV0040      1.674789e-02  1.726895e-02  1.780030e-02  1.834189e-02
## ASV0496     -1.743802e-02 -1.819705e-02 -1.897532e-02 -1.977255e-02
## ASV0052      1.465064e-02  1.515310e-02  1.567049e-02  1.620322e-02
## ASV3828     -2.682349e-02 -2.734087e-02 -2.786177e-02 -2.838625e-02
## ASV1930      1.359302e-02  1.378531e-02  1.397400e-02  1.415888e-02
## ASV2126      3.613392e-02  3.721689e-02  3.832527e-02  3.945942e-02
## ASV0793      5.847542e-02  6.051652e-02  6.261828e-02  6.478246e-02
## ASV0299     -6.925758e-03 -7.413244e-03 -7.928502e-03 -8.472488e-03
## ASV0208      4.065503e-02  4.209938e-02  4.358764e-02  4.512080e-02
## ASV0511     -7.050067e-03 -7.206728e-03 -7.369510e-03 -7.538720e-03
## ASV1123     -2.048650e-02 -2.055610e-02 -2.059730e-02 -2.060817e-02
## ASV0099      4.634707e-03  4.875778e-03  5.126594e-03  5.387351e-03
## ASV0752     -3.604743e-02 -3.742855e-02 -3.885270e-02 -4.032061e-02
## ASV0883      4.359894e-02  4.498606e-02  4.639642e-02  4.782944e-02
## ASV0683      5.714664e-02  5.913276e-02  6.116843e-02  6.325390e-02
## ASV4117     -8.376410e-02 -8.669839e-02 -8.971483e-02 -9.281486e-02
## ASV2172     -3.564900e-03 -3.913038e-03 -4.281178e-03 -4.669961e-03
## ASV0330     -1.671403e-02 -1.734275e-02 -1.799252e-02 -1.866389e-02
## ASV0728      6.258611e-02  6.444194e-02  6.634070e-02  6.828336e-02
## ASV0499      2.354500e-02  2.439837e-02  2.527474e-02  2.617428e-02
## ASV0120     -2.614329e-02 -2.677022e-02 -2.739789e-02 -2.802546e-02
## ASV1446     -4.782235e-03 -5.625537e-03 -6.520387e-03 -7.468445e-03
## ASV17171    -6.269433e-02 -6.487751e-02 -6.712079e-02 -6.942463e-02
## ASV0533      7.080591e-03  7.345123e-03  7.616093e-03  7.893485e-03
## ASV2495     -3.092613e-02 -3.219267e-02 -3.349261e-02 -3.482577e-02
## ASV5582      3.459971e-03  3.017644e-03  2.536369e-03  2.014020e-03
## ASV1488      3.483511e-03  3.361544e-03  3.224165e-03  3.070711e-03
## ASV0682      1.694959e-02  1.752420e-02  1.811049e-02  1.870823e-02
## ASV0068     -2.007443e-02 -2.053597e-02 -2.099623e-02 -2.145463e-02
## ASV1987     -7.858390e-02 -8.143567e-02 -8.436197e-02 -8.736325e-02
## ASV0035     -1.895252e-02 -2.000853e-02 -2.111307e-02 -2.226752e-02
## ASV7192     -2.631095e-02 -2.686010e-02 -2.740703e-02 -2.795117e-02
## ASV0873     -1.221305e-01 -1.273876e-01 -1.327740e-01 -1.382891e-01
## ASV4749     -3.146768e-02 -3.307722e-02 -3.474454e-02 -3.647049e-02
## ASV2174      4.404007e-03  4.120332e-03  3.816542e-03  3.492408e-03
## ASV1476     -3.616642e-02 -3.755821e-02 -3.899227e-02 -4.046939e-02
## ASV0740     -9.785572e-02 -1.016504e-01 -1.055688e-01 -1.096136e-01
## ASV0170     -1.484346e-02 -1.534185e-02 -1.585381e-02 -1.637956e-02
## ASV2466     -7.042882e-02 -7.281342e-02 -7.525741e-02 -7.776096e-02
## ASV1709      3.052544e-02  3.208624e-02  3.373181e-02  3.546606e-02
## ASV6170     -1.207583e-01 -1.249182e-01 -1.291774e-01 -1.335357e-01
## ASV3673      6.358094e-02  6.581440e-02  6.810050e-02  7.043893e-02
## ASV1745     -2.120392e-02 -2.203653e-02 -2.289313e-02 -2.377393e-02

stats::glm for first 500

library(stats)

logreg_500 <- stats::glm(as.factor(Clade) ~ . ,
                          data = lr_clr_df_500[,-1],
                          family = "binomial")
summary(logreg_500)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_df_500[, -1])
## 
## Coefficients: (269 not defined because of singularities)
##               Estimate Std. Error   z value Pr(>|z|)    
## (Intercept)  3.365e+24  7.553e+17   4455140   <2e-16 ***
## ASV1236      6.734e+28  7.877e+21   8549812   <2e-16 ***
## ASV0421     -3.648e+27  4.745e+20  -7688601   <2e-16 ***
## ASV0691     -6.872e+29  7.457e+21 -92145182   <2e-16 ***
## ASV0899      3.620e+29  8.766e+21  41293382   <2e-16 ***
## ASV1004     -1.943e+29  1.887e+22 -10297852   <2e-16 ***
## ASV1041      9.920e+29  1.932e+22  51347544   <2e-16 ***
## ASV1058     -5.604e+28  2.109e+22  -2656746   <2e-16 ***
## ASV12542    -2.944e+29  2.481e+22 -11866103   <2e-16 ***
## ASV1294      1.016e+29  4.036e+21  25168098   <2e-16 ***
## ASV13113    -3.196e+27  2.416e+20 -13225842   <2e-16 ***
## ASV1318     -4.340e+27  9.871e+20  -4397003   <2e-16 ***
## ASV2269      3.607e+30  1.764e+23  20448656   <2e-16 ***
## ASV2542     -4.161e+27  2.173e+20 -19146775   <2e-16 ***
## ASV2660      1.002e+30  3.044e+22  32932570   <2e-16 ***
## ASV2737     -1.038e+30  2.012e+22 -51601366   <2e-16 ***
## ASV2840      1.119e+29  5.483e+21  20412831   <2e-16 ***
## ASV3053      6.275e+30  2.327e+23  26961022   <2e-16 ***
## ASV3077     -5.247e+29  1.769e+22 -29659647   <2e-16 ***
## ASV3134     -6.140e+26  7.450e+19  -8241929   <2e-16 ***
## ASV3140     -1.245e+29  7.119e+21 -17487055   <2e-16 ***
## ASV3579      1.824e+28  1.133e+21  16095103   <2e-16 ***
## ASV6119             NA         NA        NA       NA    
## ASV7557             NA         NA        NA       NA    
## ASV8422             NA         NA        NA       NA    
## ASV1086             NA         NA        NA       NA    
## ASV1310     -6.441e+27  2.727e+21  -2361738   <2e-16 ***
## ASV15750     2.739e+28  1.020e+22   2685319   <2e-16 ***
## ASV16905            NA         NA        NA       NA    
## ASV2033     -1.854e+29  7.220e+21 -25674834   <2e-16 ***
## ASV2089             NA         NA        NA       NA    
## ASV2127      6.170e+28  6.107e+21  10104634   <2e-16 ***
## ASV2725      5.098e+29  1.063e+22  47959564   <2e-16 ***
## ASV2804             NA         NA        NA       NA    
## ASV3075      1.983e+28  3.872e+21   5120891   <2e-16 ***
## ASV3327     -8.463e+28  2.520e+21 -33582758   <2e-16 ***
## ASV3342      3.453e+27  1.368e+21   2523346   <2e-16 ***
## ASV3532     -3.843e+29  1.553e+22 -24744738   <2e-16 ***
## ASV3600      3.029e+27  3.781e+21    801029   <2e-16 ***
## ASV4013      8.242e+29  4.297e+22  19179508   <2e-16 ***
## ASV4136     -4.437e+29  1.005e+22 -44142967   <2e-16 ***
## ASV4195             NA         NA        NA       NA    
## ASV4407             NA         NA        NA       NA    
## ASV4717             NA         NA        NA       NA    
## ASV6794             NA         NA        NA       NA    
## ASV8324             NA         NA        NA       NA    
## ASV8981      2.590e+28  1.807e+21  14336596   <2e-16 ***
## ASV9859      1.140e+29  4.747e+21  24019076   <2e-16 ***
## ASV0936     -2.726e+28  5.069e+20 -53775218   <2e-16 ***
## ASV12683            NA         NA        NA       NA    
## ASV1293      2.111e+29  6.346e+21  33262200   <2e-16 ***
## ASV13055            NA         NA        NA       NA    
## ASV17063            NA         NA        NA       NA    
## ASV2228             NA         NA        NA       NA    
## ASV2769     -5.737e+29  3.903e+22 -14701528   <2e-16 ***
## ASV2803     -2.270e+29  2.230e+22 -10178739   <2e-16 ***
## ASV2896      5.034e+27  1.083e+20  46498426   <2e-16 ***
## ASV3062             NA         NA        NA       NA    
## ASV3107      3.218e+26  9.323e+19   3451124   <2e-16 ***
## ASV3265      2.217e+29  5.755e+21  38522384   <2e-16 ***
## ASV3666             NA         NA        NA       NA    
## ASV4497      5.080e+29  6.125e+21  82934294   <2e-16 ***
## ASV6914             NA         NA        NA       NA    
## ASV0576     -1.413e+29  3.400e+21 -41571707   <2e-16 ***
## ASV0673     -1.676e+29  1.076e+22 -15579312   <2e-16 ***
## ASV0772     -5.129e+28  1.300e+22  -3946466   <2e-16 ***
## ASV0862      8.939e+28  2.602e+22   3434799   <2e-16 ***
## ASV0898             NA         NA        NA       NA    
## ASV0910     -2.701e+28  5.924e+20 -45593216   <2e-16 ***
## ASV0964             NA         NA        NA       NA    
## ASV10059     8.888e+26  3.201e+19  27767562   <2e-16 ***
## ASV10263            NA         NA        NA       NA    
## ASV1088      5.240e+28  4.251e+21  12326886   <2e-16 ***
## ASV1101             NA         NA        NA       NA    
## ASV1183     -7.451e+27  7.724e+20  -9647179   <2e-16 ***
## ASV11956            NA         NA        NA       NA    
## ASV12774            NA         NA        NA       NA    
## ASV1321             NA         NA        NA       NA    
## ASV13793            NA         NA        NA       NA    
## ASV14482            NA         NA        NA       NA    
## ASV15483            NA         NA        NA       NA    
## ASV2062             NA         NA        NA       NA    
## ASV2132      7.987e+25  1.385e+20    576770   <2e-16 ***
## ASV2413             NA         NA        NA       NA    
## ASV2490             NA         NA        NA       NA    
## ASV2594      4.653e+27  4.638e+20  10031166   <2e-16 ***
## ASV2822             NA         NA        NA       NA    
## ASV2863             NA         NA        NA       NA    
## ASV2910             NA         NA        NA       NA    
## ASV2980      1.137e+29  2.889e+21  39374891   <2e-16 ***
## ASV3307             NA         NA        NA       NA    
## ASV3474             NA         NA        NA       NA    
## ASV3502     -1.248e+29  5.208e+21 -23965364   <2e-16 ***
## ASV4236             NA         NA        NA       NA    
## ASV4842             NA         NA        NA       NA    
## ASV4894             NA         NA        NA       NA    
## ASV5290             NA         NA        NA       NA    
## ASV5501     -4.226e+29  1.655e+22 -25534860   <2e-16 ***
## ASV5795             NA         NA        NA       NA    
## ASV5987             NA         NA        NA       NA    
## ASV6267             NA         NA        NA       NA    
## ASV6862             NA         NA        NA       NA    
## ASV7145             NA         NA        NA       NA    
## ASV7673             NA         NA        NA       NA    
## ASV7789             NA         NA        NA       NA    
## ASV7809             NA         NA        NA       NA    
## ASV8002             NA         NA        NA       NA    
## ASV8205      3.986e+27  4.371e+20   9119652   <2e-16 ***
## ASV9155             NA         NA        NA       NA    
## ASV9221      2.112e+29  7.015e+21  30108341   <2e-16 ***
## ASV9311             NA         NA        NA       NA    
## ASV9557             NA         NA        NA       NA    
## ASV9936             NA         NA        NA       NA    
## ASV1445      2.152e+28  1.898e+21  11341359   <2e-16 ***
## ASV4232      7.680e+26  2.712e+19  28320193   <2e-16 ***
## ASV6479     -1.475e+28  2.927e+20 -50387307   <2e-16 ***
## ASV0142      3.447e+29  9.967e+21  34581617   <2e-16 ***
## ASV0378      2.866e+28  6.508e+20  44044898   <2e-16 ***
## ASV1122     -6.034e+28  2.783e+21 -21676663   <2e-16 ***
## ASV0123     -1.909e+29  1.190e+22 -16040768   <2e-16 ***
## ASV2064      1.458e+29  2.785e+21  52368055   <2e-16 ***
## ASV4459     -6.508e+27  1.636e+21  -3978313   <2e-16 ***
## ASV0448      3.365e+26  7.000e+19   4806815   <2e-16 ***
## ASV0397      5.490e+27  1.784e+20  30770580   <2e-16 ***
## ASV0485      3.399e+26  4.406e+20    771529   <2e-16 ***
## ASV1566             NA         NA        NA       NA    
## ASV1365      6.724e+28  6.510e+21  10329350   <2e-16 ***
## ASV1065     -3.355e+28  7.514e+20 -44647489   <2e-16 ***
## ASV0722      1.932e+28  7.323e+20  26379161   <2e-16 ***
## ASV12660            NA         NA        NA       NA    
## ASV0223     -1.845e+27  4.095e+19 -45044973   <2e-16 ***
## ASV0229      1.037e+29  4.138e+21  25050298   <2e-16 ***
## ASV0877     -1.197e+29  2.312e+21 -51762459   <2e-16 ***
## ASV0983     -4.692e+27  1.227e+20 -38229669   <2e-16 ***
## ASV0626             NA         NA        NA       NA    
## ASV4146      1.267e+29  5.748e+21  22051982   <2e-16 ***
## ASV4175      1.468e+29  6.390e+21  22977944   <2e-16 ***
## ASV2082      4.697e+27  7.948e+21    590917   <2e-16 ***
## ASV2272      2.143e+27  1.558e+20  13759437   <2e-16 ***
## ASV2245      1.036e+28  1.416e+21   7320995   <2e-16 ***
## ASV0590             NA         NA        NA       NA    
## ASV0217     -6.082e+27  3.254e+20 -18688201   <2e-16 ***
## ASV0416     -9.352e+28  4.011e+21 -23317562   <2e-16 ***
## ASV1056      4.379e+28  9.560e+20  45806293   <2e-16 ***
## ASV7777      1.313e+26  3.125e+18  42026630   <2e-16 ***
## ASV0455     -1.599e+27  1.868e+20  -8559833   <2e-16 ***
## ASV0604             NA         NA        NA       NA    
## ASV6100     -8.892e+26  2.452e+19 -36258795   <2e-16 ***
## ASV11359            NA         NA        NA       NA    
## ASV6604     -1.357e+27  9.241e+19 -14686255   <2e-16 ***
## ASV5004     -3.297e+28  2.064e+21 -15968479   <2e-16 ***
## ASV1483      9.259e+28  5.122e+21  18078096   <2e-16 ***
## ASV9773      3.542e+24  9.017e+17   3927869   <2e-16 ***
## ASV4059      3.539e+27  1.240e+20  28534190   <2e-16 ***
## ASV1193     -1.095e+27  2.595e+19 -42211925   <2e-16 ***
## ASV4610             NA         NA        NA       NA    
## ASV0742             NA         NA        NA       NA    
## ASV1502      2.062e+28  2.101e+21   9815587   <2e-16 ***
## ASV0195     -1.136e+28  8.765e+20 -12964719   <2e-16 ***
## ASV1213     -1.282e+28  7.604e+20 -16864651   <2e-16 ***
## ASV1648     -2.280e+27  2.810e+20  -8113640   <2e-16 ***
## ASV6984     -1.247e+28  7.033e+20 -17735269   <2e-16 ***
## ASV0396      6.608e+27  3.126e+20  21138856   <2e-16 ***
## ASV4297             NA         NA        NA       NA    
## ASV2622      3.120e+27  2.408e+20  12954812   <2e-16 ***
## ASV3512      2.229e+27  2.932e+20   7604982   <2e-16 ***
## ASV2411             NA         NA        NA       NA    
## ASV2291             NA         NA        NA       NA    
## ASV0807      1.262e+28  1.128e+21  11185166   <2e-16 ***
## ASV1292      4.892e+27  7.702e+20   6352014   <2e-16 ***
## ASV1035             NA         NA        NA       NA    
## ASV0070      1.154e+26  1.873e+19   6158858   <2e-16 ***
## ASV0255     -3.377e+27  4.012e+20  -8418180   <2e-16 ***
## ASV0057     -8.343e+26  2.065e+19 -40399581   <2e-16 ***
## ASV0077      6.815e+26  4.068e+19  16755173   <2e-16 ***
## ASV0625     -3.036e+27  4.492e+20  -6758212   <2e-16 ***
## ASV2464             NA         NA        NA       NA    
## ASV1315      1.411e+29  7.399e+21  19067690   <2e-16 ***
## ASV2673     -1.360e+27  3.627e+20  -3749327   <2e-16 ***
## ASV2161     -1.153e+29  6.076e+21 -18978266   <2e-16 ***
## ASV0337      3.202e+27  3.745e+20   8551232   <2e-16 ***
## ASV7680      5.084e+27  2.001e+21   2541443   <2e-16 ***
## ASV0611      5.369e+27  3.191e+20  16822498   <2e-16 ***
## ASV3118     -9.577e+28  7.474e+21 -12812912   <2e-16 ***
## ASV1284     -1.771e+26  3.322e+19  -5330863   <2e-16 ***
## ASV0889             NA         NA        NA       NA    
## ASV4649      5.395e+27  6.636e+20   8130188   <2e-16 ***
## ASV1108      1.014e+28  4.627e+20  21915994   <2e-16 ***
## ASV0738      1.901e+27  5.845e+19  32515307   <2e-16 ***
## ASV0473     -5.865e+26  7.283e+19  -8052716   <2e-16 ***
## ASV0598             NA         NA        NA       NA    
## ASV0429      5.096e+27  1.169e+21   4358585   <2e-16 ***
## ASV1549     -3.105e+26  2.117e+19 -14663606   <2e-16 ***
## ASV1203      5.602e+27  2.656e+20  21092741   <2e-16 ***
## ASV4532     -2.086e+27  1.294e+20 -16126745   <2e-16 ***
## ASV0274     -2.665e+27  2.179e+20 -12227315   <2e-16 ***
## ASV0163      2.696e+27  1.283e+20  21009336   <2e-16 ***
## ASV1298      5.559e+27  4.606e+20  12070247   <2e-16 ***
## ASV9424     -8.099e+27  9.797e+20  -8266614   <2e-16 ***
## ASV0412     -3.417e+28  3.259e+21 -10481715   <2e-16 ***
## ASV0284      3.665e+27  2.305e+20  15901523   <2e-16 ***
## ASV0620             NA         NA        NA       NA    
## ASV0153      4.867e+27  3.860e+20  12608412   <2e-16 ***
## ASV0498     -6.103e+27  5.736e+20 -10639767   <2e-16 ***
## ASV0097      4.910e+26  4.329e+19  11343352   <2e-16 ***
## ASV0104      3.332e+27  1.657e+20  20103965   <2e-16 ***
## ASV1282      2.075e+28  1.155e+21  17960841   <2e-16 ***
## ASV3883      1.485e+28  6.012e+20  24697163   <2e-16 ***
## ASV0801      4.697e+27  3.127e+20  15019671   <2e-16 ***
## ASV1611     -5.576e+27  8.200e+20  -6800102   <2e-16 ***
## ASV0227      3.432e+27  3.254e+20  10547182   <2e-16 ***
## ASV0833             NA         NA        NA       NA    
## ASV0718      6.751e+27  5.246e+20  12869729   <2e-16 ***
## ASV1139             NA         NA        NA       NA    
## ASV0766      1.784e+28  1.552e+21  11493235   <2e-16 ***
## ASV2091     -1.802e+28  7.795e+20 -23122453   <2e-16 ***
## ASV1238      7.937e+27  2.282e+21   3478771   <2e-16 ***
## ASV9193             NA         NA        NA       NA    
## ASV0290     -1.120e+29  5.984e+21 -18720754   <2e-16 ***
## ASV0231      1.608e+27  7.642e+19  21040172   <2e-16 ***
## ASV0185      2.379e+26  1.677e+19  14185867   <2e-16 ***
## ASV2330             NA         NA        NA       NA    
## ASV3119      6.440e+26  9.435e+19   6825835   <2e-16 ***
## ASV2368      1.075e+27  1.241e+20   8662788   <2e-16 ***
## ASV0122      8.436e+26  6.313e+19  13361445   <2e-16 ***
## ASV1044     -2.838e+27  3.193e+20  -8888219   <2e-16 ***
## ASV0160     -6.269e+24  6.435e+19    -97421   <2e-16 ***
## ASV0326     -1.111e+26  1.062e+19 -10462061   <2e-16 ***
## ASV1388     -1.478e+26  1.149e+20  -1286560   <2e-16 ***
## ASV0792             NA         NA        NA       NA    
## ASV0036      3.807e+26  6.405e+19   5944935   <2e-16 ***
## ASV2125      1.250e+27  3.942e+19  31702730   <2e-16 ***
## ASV1075      2.865e+26  3.784e+19   7573138   <2e-16 ***
## ASV0390     -1.588e+26  2.865e+19  -5541211   <2e-16 ***
## ASV3790     -2.345e+27  7.708e+19 -30429042   <2e-16 ***
## ASV1535     -2.679e+26  1.155e+20  -2319101   <2e-16 ***
## ASV0263             NA         NA        NA       NA    
## ASV0675      6.067e+26  1.823e+19  33281690   <2e-16 ***
## ASV3348     -6.506e+26  6.778e+19  -9598312   <2e-16 ***
## ASV0058      3.844e+26  1.133e+19  33934764   <2e-16 ***
## ASV4142             NA         NA        NA       NA    
## ASV0059     -4.155e+25  1.098e+19  -3783418   <2e-16 ***
## ASV0013     -3.581e+25  5.209e+19   -687322   <2e-16 ***
## ASV0033     -3.528e+27  2.763e+20 -12769820   <2e-16 ***
## ASV4354             NA         NA        NA       NA    
## ASV0022      1.066e+27  7.724e+19  13798048   <2e-16 ***
## ASV0134     -3.857e+27  2.600e+20 -14833628   <2e-16 ***
## ASV0415      4.202e+26  6.435e+20    653063   <2e-16 ***
## ASV10103            NA         NA        NA       NA    
## ASV1613     -1.160e+28  8.210e+20 -14124176   <2e-16 ***
## ASV0135      5.952e+25  1.336e+19   4455140   <2e-16 ***
## ASV0469             NA         NA        NA       NA    
## ASV0471      3.040e+26  1.691e+20   1798327   <2e-16 ***
## ASV0451      1.031e+25  1.257e+19    820228   <2e-16 ***
## ASV0747     -2.304e+27  1.086e+20 -21210722   <2e-16 ***
## ASV1314      3.589e+25  8.057e+18   4455140   <2e-16 ***
## ASV0425             NA         NA        NA       NA    
## ASV0559      9.106e+26  6.336e+20   1437314   <2e-16 ***
## ASV0148     -5.587e+25  7.492e+18  -7456917   <2e-16 ***
## ASV0129      4.810e+25  3.397e+18  14161847   <2e-16 ***
## ASV1072     -1.526e+27  1.136e+20 -13434470   <2e-16 ***
## ASV2390             NA         NA        NA       NA    
## ASV0548      5.334e+26  7.540e+19   7073840   <2e-16 ***
## ASV0168     -1.521e+25  3.831e+18  -3969612   <2e-16 ***
## ASV0066     -5.903e+24  5.615e+17 -10513320   <2e-16 ***
## ASV0468     -4.286e+23  1.520e+17  -2819147   <2e-16 ***
## ASV0172      4.820e+25  9.454e+18   5098194   <2e-16 ***
## ASV0236     -1.778e+27  3.521e+19 -50495342   <2e-16 ***
## ASV0250     -3.209e+25  7.459e+18  -4302139   <2e-16 ***
## ASV0338     -2.273e+26  9.642e+19  -2357438   <2e-16 ***
## ASV0450     -2.657e+26  4.231e+19  -6280978   <2e-16 ***
## ASV0377             NA         NA        NA       NA    
## ASV1022     -3.214e+25  7.477e+18  -4298787   <2e-16 ***
## ASV6174             NA         NA        NA       NA    
## ASV0786             NA         NA        NA       NA    
## ASV0053     -8.610e+24  1.175e+19   -732625   <2e-16 ***
## ASV0697      1.543e+27  1.957e+20   7881590   <2e-16 ***
## ASV0785      2.371e+26  4.563e+19   5195032   <2e-16 ***
## ASV1967     -7.948e+25  1.431e+19  -5555794   <2e-16 ***
## ASV0385     -9.049e+26  2.859e+19 -31656179   <2e-16 ***
## ASV0295      2.494e+25  5.797e+18   4302609   <2e-16 ***
## ASV0072      2.473e+25  5.833e+18   4239359   <2e-16 ***
## ASV0157     -4.871e+25  2.318e+18 -21011084   <2e-16 ***
## ASV0501     -6.432e+27  2.152e+20 -29893804   <2e-16 ***
## ASV10729     2.606e+27  1.857e+20  14037344   <2e-16 ***
## ASV1470             NA         NA        NA       NA    
## ASV0050     -3.446e+27  2.890e+20 -11924848   <2e-16 ***
## ASV0411      1.450e+26  1.092e+19  13279190   <2e-16 ***
## ASV0549     -3.976e+26  3.550e+19 -11199578   <2e-16 ***
## ASV0184     -1.793e+24  4.024e+17  -4455140   <2e-16 ***
## ASV0705      3.550e+25  6.519e+18   5444603   <2e-16 ***
## ASV1715     -1.052e+27  5.512e+19 -19084967   <2e-16 ***
## ASV0603      5.643e+25  2.420e+19   2331574   <2e-16 ***
## ASV0826             NA         NA        NA       NA    
## ASV0034     -3.104e+25  6.968e+18  -4455140   <2e-16 ***
## ASV0838     -2.247e+27  1.824e+20 -12318957   <2e-16 ***
## ASV0614     -3.673e+25  1.228e+19  -2990984   <2e-16 ***
## ASV0014      8.634e+26  9.426e+19   9159881   <2e-16 ***
## ASV0585             NA         NA        NA       NA    
## ASV0016     -2.513e+27  1.331e+20 -18879340   <2e-16 ***
## ASV5394      1.345e+26  7.053e+19   1906834   <2e-16 ***
## ASV0666             NA         NA        NA       NA    
## ASV2085             NA         NA        NA       NA    
## ASV0003      1.294e+27  1.069e+20  12098345   <2e-16 ***
## ASV0346      7.695e+26  4.560e+19  16875761   <2e-16 ***
## ASV0267     -1.078e+27  4.833e+19 -22294991   <2e-16 ***
## ASV0353     -8.834e+24  3.682e+19   -239907   <2e-16 ***
## ASV2419      1.213e+27  2.986e+20   4062634   <2e-16 ***
## ASV0447             NA         NA        NA       NA    
## ASV0654             NA         NA        NA       NA    
## ASV0151     -1.054e+27  3.947e+19 -26711955   <2e-16 ***
## ASV0065      3.179e+25  2.107e+19   1509198   <2e-16 ***
## ASV0527     -1.562e+27  1.107e+20 -14109655   <2e-16 ***
## ASV4055             NA         NA        NA       NA    
## ASV0166             NA         NA        NA       NA    
## ASV0417     -1.310e+25  1.916e+19   -683887   <2e-16 ***
## ASV0078      7.889e+24  8.883e+17   8880320   <2e-16 ***
## ASV0322             NA         NA        NA       NA    
## ASV0156     -1.010e+26  2.738e+19  -3687845   <2e-16 ***
## ASV0648             NA         NA        NA       NA    
## ASV0407      1.663e+25  3.732e+18   4455140   <2e-16 ***
## ASV2030             NA         NA        NA       NA    
## ASV0300     -1.225e+26  1.168e+19 -10492054   <2e-16 ***
## ASV1150     -1.465e+26  8.843e+18 -16567236   <2e-16 ***
## ASV0958      1.179e+26  3.939e+19   2992785   <2e-16 ***
## ASV0216             NA         NA        NA       NA    
## ASV0446             NA         NA        NA       NA    
## ASV0367             NA         NA        NA       NA    
## ASV0200             NA         NA        NA       NA    
## ASV0334             NA         NA        NA       NA    
## ASV1311             NA         NA        NA       NA    
## ASV0458             NA         NA        NA       NA    
## ASV1371             NA         NA        NA       NA    
## ASV0418             NA         NA        NA       NA    
## ASV0004     -3.101e+25  2.914e+18 -10643188   <2e-16 ***
## ASV1943             NA         NA        NA       NA    
## ASV1495             NA         NA        NA       NA    
## ASV0901             NA         NA        NA       NA    
## ASV0628             NA         NA        NA       NA    
## ASV0400             NA         NA        NA       NA    
## ASV0116             NA         NA        NA       NA    
## ASV0788             NA         NA        NA       NA    
## ASV0117     -2.375e+24  2.151e+17 -11039688   <2e-16 ***
## ASV3137             NA         NA        NA       NA    
## ASV0001             NA         NA        NA       NA    
## ASV1651             NA         NA        NA       NA    
## ASV1692             NA         NA        NA       NA    
## ASV0660             NA         NA        NA       NA    
## ASV0508             NA         NA        NA       NA    
## ASV1660             NA         NA        NA       NA    
## ASV0233             NA         NA        NA       NA    
## ASV1343             NA         NA        NA       NA    
## ASV0209             NA         NA        NA       NA    
## ASV0193             NA         NA        NA       NA    
## ASV0357             NA         NA        NA       NA    
## ASV0198             NA         NA        NA       NA    
## ASV0007             NA         NA        NA       NA    
## ASV1772             NA         NA        NA       NA    
## ASV0009             NA         NA        NA       NA    
## ASV0006             NA         NA        NA       NA    
## ASV0011             NA         NA        NA       NA    
## ASV0015             NA         NA        NA       NA    
## ASV0017             NA         NA        NA       NA    
## ASV0235             NA         NA        NA       NA    
## ASV0382             NA         NA        NA       NA    
## ASV2357             NA         NA        NA       NA    
## ASV0567      9.283e+25  3.757e+19   2470964   <2e-16 ***
## ASV0165             NA         NA        NA       NA    
## ASV0005             NA         NA        NA       NA    
## ASV0384             NA         NA        NA       NA    
## ASV0002             NA         NA        NA       NA    
## ASV3017             NA         NA        NA       NA    
## ASV0091             NA         NA        NA       NA    
## ASV0186             NA         NA        NA       NA    
## ASV0370             NA         NA        NA       NA    
## ASV0018             NA         NA        NA       NA    
## ASV1377             NA         NA        NA       NA    
## ASV0019             NA         NA        NA       NA    
## ASV0023             NA         NA        NA       NA    
## ASV2194             NA         NA        NA       NA    
## ASV1155             NA         NA        NA       NA    
## ASV0510             NA         NA        NA       NA    
## ASV2371             NA         NA        NA       NA    
## ASV0024             NA         NA        NA       NA    
## ASV2452             NA         NA        NA       NA    
## ASV2332             NA         NA        NA       NA    
## ASV2591             NA         NA        NA       NA    
## ASV0521             NA         NA        NA       NA    
## ASV5542             NA         NA        NA       NA    
## ASV0336             NA         NA        NA       NA    
## ASV10102            NA         NA        NA       NA    
## ASV16823            NA         NA        NA       NA    
## ASV3104             NA         NA        NA       NA    
## ASV0781             NA         NA        NA       NA    
## ASV10899            NA         NA        NA       NA    
## ASV11222            NA         NA        NA       NA    
## ASV11327            NA         NA        NA       NA    
## ASV12458            NA         NA        NA       NA    
## ASV1636             NA         NA        NA       NA    
## ASV1890             NA         NA        NA       NA    
## ASV2898             NA         NA        NA       NA    
## ASV8328             NA         NA        NA       NA    
## ASV0709             NA         NA        NA       NA    
## ASV0856             NA         NA        NA       NA    
## ASV0909             NA         NA        NA       NA    
## ASV0937             NA         NA        NA       NA    
## ASV11390            NA         NA        NA       NA    
## ASV11966            NA         NA        NA       NA    
## ASV12990            NA         NA        NA       NA    
## ASV14797            NA         NA        NA       NA    
## ASV14904            NA         NA        NA       NA    
## ASV15304            NA         NA        NA       NA    
## ASV16696            NA         NA        NA       NA    
## ASV1690             NA         NA        NA       NA    
## ASV2029             NA         NA        NA       NA    
## ASV2834             NA         NA        NA       NA    
## ASV4003             NA         NA        NA       NA    
## ASV4064             NA         NA        NA       NA    
## ASV4294             NA         NA        NA       NA    
## ASV4609             NA         NA        NA       NA    
## ASV6283             NA         NA        NA       NA    
## ASV6491             NA         NA        NA       NA    
## ASV7453             NA         NA        NA       NA    
## ASV7959             NA         NA        NA       NA    
## ASV8219             NA         NA        NA       NA    
## ASV8547             NA         NA        NA       NA    
## ASV9319             NA         NA        NA       NA    
## ASV9382             NA         NA        NA       NA    
## ASV11516            NA         NA        NA       NA    
## ASV14377            NA         NA        NA       NA    
## ASV1867             NA         NA        NA       NA    
## ASV1895             NA         NA        NA       NA    
## ASV3168             NA         NA        NA       NA    
## ASV4449             NA         NA        NA       NA    
## ASV6596             NA         NA        NA       NA    
## ASV7492             NA         NA        NA       NA    
## ASV9854             NA         NA        NA       NA    
## ASV6296             NA         NA        NA       NA    
## ASV4201             NA         NA        NA       NA    
## ASV0552             NA         NA        NA       NA    
## ASV3671             NA         NA        NA       NA    
## ASV3529             NA         NA        NA       NA    
## ASV1060             NA         NA        NA       NA    
## ASV0239             NA         NA        NA       NA    
## ASV5711             NA         NA        NA       NA    
## ASV4152             NA         NA        NA       NA    
## ASV1461             NA         NA        NA       NA    
## ASV2877             NA         NA        NA       NA    
## ASV0012             NA         NA        NA       NA    
## ASV9823             NA         NA        NA       NA    
## ASV0008             NA         NA        NA       NA    
## ASV7832             NA         NA        NA       NA    
## ASV1915             NA         NA        NA       NA    
## ASV0055             NA         NA        NA       NA    
## ASV0032             NA         NA        NA       NA    
## ASV2977             NA         NA        NA       NA    
## ASV0466             NA         NA        NA       NA    
## ASV3866             NA         NA        NA       NA    
## ASV0040             NA         NA        NA       NA    
## ASV0496             NA         NA        NA       NA    
## ASV0052             NA         NA        NA       NA    
## ASV3828             NA         NA        NA       NA    
## ASV1930             NA         NA        NA       NA    
## ASV2126             NA         NA        NA       NA    
## ASV0793             NA         NA        NA       NA    
## ASV0299             NA         NA        NA       NA    
## ASV0208             NA         NA        NA       NA    
## ASV0511             NA         NA        NA       NA    
## ASV1123             NA         NA        NA       NA    
## ASV0099             NA         NA        NA       NA    
## ASV0752             NA         NA        NA       NA    
## ASV0883             NA         NA        NA       NA    
## ASV0683     -1.500e+28  1.058e+21 -14169982   <2e-16 ***
## ASV4117             NA         NA        NA       NA    
## ASV2172             NA         NA        NA       NA    
## ASV0330             NA         NA        NA       NA    
## ASV0728             NA         NA        NA       NA    
## ASV0499             NA         NA        NA       NA    
## ASV0120             NA         NA        NA       NA    
## ASV1446             NA         NA        NA       NA    
## ASV17171            NA         NA        NA       NA    
## ASV0533             NA         NA        NA       NA    
## ASV2495             NA         NA        NA       NA    
## ASV5582             NA         NA        NA       NA    
## ASV1488             NA         NA        NA       NA    
## ASV0682             NA         NA        NA       NA    
## ASV0068             NA         NA        NA       NA    
## ASV1987             NA         NA        NA       NA    
## ASV0035             NA         NA        NA       NA    
## ASV7192             NA         NA        NA       NA    
## ASV0873             NA         NA        NA       NA    
## ASV4749             NA         NA        NA       NA    
## ASV2174             NA         NA        NA       NA    
## ASV1476             NA         NA        NA       NA    
## ASV0740             NA         NA        NA       NA    
## ASV0170             NA         NA        NA       NA    
## ASV2466             NA         NA        NA       NA    
## ASV1709             NA         NA        NA       NA    
## ASV6170             NA         NA        NA       NA    
## ASV3673             NA         NA        NA       NA    
## ASV1745             NA         NA        NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:  385.39  on 277  degrees of freedom
## Residual deviance: 3171.84  on  46  degrees of freedom
## AIC: 3635.8
## 
## Number of Fisher Scoring iterations: 11
  • The p-values above are all the same which is not good.

From PCA of Clade C, there were about 150 or so ASVs that contributed the most in Dimension 1

bind_cols(lr_data[,1:2], 
lr_data[3:152] %>% clr() # sample id and Clade
) -> lr_clr_150

logreg_150 <- stats::glm(as.factor(Clade) ~ . ,
                          data = lr_clr_150[,-1],
                          family = "binomial")
summary(logreg_150)
## 
## Call:
## stats::glm(formula = as.factor(Clade) ~ ., family = "binomial", 
##     data = lr_clr_150[, -1])
## 
## Coefficients: (71 not defined because of singularities)
##               Estimate Std. Error   z value Pr(>|z|)    
## (Intercept)  2.149e+14  4.856e+06  44249740   <2e-16 ***
## ASV1236      6.118e+18  7.124e+10  85883777   <2e-16 ***
## ASV0421     -5.197e+17  8.905e+09 -58360413   <2e-16 ***
## ASV0691      3.128e+26  2.109e+19  14829839   <2e-16 ***
## ASV0899     -5.618e+26  3.788e+19 -14829839   <2e-16 ***
## ASV1004      3.720e+19  4.870e+11  76384245   <2e-16 ***
## ASV1041      4.433e+26  2.989e+19  14829839   <2e-16 ***
## ASV1058      2.926e+19  4.996e+11  58560540   <2e-16 ***
## ASV12542    -5.350e+27  3.607e+20 -14829840   <2e-16 ***
## ASV1294      3.695e+25  2.492e+18  14829840   <2e-16 ***
## ASV13113     4.072e+29  2.746e+22  14829839   <2e-16 ***
## ASV1318      2.966e+17  5.998e+09  49443492   <2e-16 ***
## ASV2269             NA         NA        NA       NA    
## ASV2542      4.543e+25  3.063e+18  14829838   <2e-16 ***
## ASV2660     -3.446e+27  2.323e+20 -14829840   <2e-16 ***
## ASV2737     -9.245e+25  6.234e+18 -14829840   <2e-16 ***
## ASV2840      4.183e+25  2.821e+18  14829837   <2e-16 ***
## ASV3053      1.633e+29  1.101e+22  14829839   <2e-16 ***
## ASV3077     -2.155e+28  1.453e+21 -14829839   <2e-16 ***
## ASV3134     -1.293e+17  1.615e+09 -80082376   <2e-16 ***
## ASV3140      2.298e+19  2.657e+11  86471491   <2e-16 ***
## ASV3579     -2.267e+16  2.802e+08 -80875064   <2e-16 ***
## ASV6119             NA         NA        NA       NA    
## ASV7557             NA         NA        NA       NA    
## ASV8422             NA         NA        NA       NA    
## ASV1086             NA         NA        NA       NA    
## ASV1310     -3.400e+25  2.293e+18 -14829839   <2e-16 ***
## ASV15750     1.484e+25  1.001e+18  14829851   <2e-16 ***
## ASV16905            NA         NA        NA       NA    
## ASV2033      4.483e+18  1.678e+11  26716873   <2e-16 ***
## ASV2089             NA         NA        NA       NA    
## ASV2127     -2.913e+16  2.876e+09 -10126318   <2e-16 ***
## ASV2725     -1.048e+24  7.064e+16 -14830125   <2e-16 ***
## ASV2804             NA         NA        NA       NA    
## ASV3075     -2.235e+16  2.934e+08 -76164934   <2e-16 ***
## ASV3327      1.397e+17  1.083e+10  12902533   <2e-16 ***
## ASV3342     -1.152e+17  4.288e+09 -26878757   <2e-16 ***
## ASV3532      1.568e+18  5.906e+10  26551172   <2e-16 ***
## ASV3600      1.219e+19  1.767e+11  69017494   <2e-16 ***
## ASV4013      5.762e+27  3.886e+20  14829839   <2e-16 ***
## ASV4136      5.761e+26  3.885e+19  14829840   <2e-16 ***
## ASV4195             NA         NA        NA       NA    
## ASV4407             NA         NA        NA       NA    
## ASV4717             NA         NA        NA       NA    
## ASV6794             NA         NA        NA       NA    
## ASV8324             NA         NA        NA       NA    
## ASV8981     -8.208e+16  2.908e+09 -28224447   <2e-16 ***
## ASV9859      7.510e+16  8.436e+08  89022102   <2e-16 ***
## ASV0936      2.117e+18  3.575e+10  59221098   <2e-16 ***
## ASV12683            NA         NA        NA       NA    
## ASV1293      2.871e+17  2.460e+10  11670920   <2e-16 ***
## ASV13055            NA         NA        NA       NA    
## ASV17063            NA         NA        NA       NA    
## ASV2228             NA         NA        NA       NA    
## ASV2769     -3.292e+27  2.220e+20 -14829839   <2e-16 ***
## ASV2803     -1.347e+27  9.085e+19 -14829840   <2e-16 ***
## ASV2896     -6.332e+16  1.848e+09 -34256411   <2e-16 ***
## ASV3062             NA         NA        NA       NA    
## ASV3107             NA         NA        NA       NA    
## ASV3265      7.403e+17  5.337e+10  13870427   <2e-16 ***
## ASV3666             NA         NA        NA       NA    
## ASV4497     -9.852e+25  6.643e+18 -14829840   <2e-16 ***
## ASV6914             NA         NA        NA       NA    
## ASV0576      4.451e+17  2.088e+10  21314782   <2e-16 ***
## ASV0673     -1.804e+25  1.216e+18 -14829838   <2e-16 ***
## ASV0772     -7.998e+18  1.251e+11 -63943266   <2e-16 ***
## ASV0862             NA         NA        NA       NA    
## ASV0898             NA         NA        NA       NA    
## ASV0910      1.612e+17  1.272e+10  12671632   <2e-16 ***
## ASV0964             NA         NA        NA       NA    
## ASV10059            NA         NA        NA       NA    
## ASV10263            NA         NA        NA       NA    
## ASV1088      6.437e+16  2.268e+09  28384567   <2e-16 ***
## ASV1101             NA         NA        NA       NA    
## ASV1183             NA         NA        NA       NA    
## ASV11956            NA         NA        NA       NA    
## ASV12774            NA         NA        NA       NA    
## ASV1321             NA         NA        NA       NA    
## ASV13793            NA         NA        NA       NA    
## ASV14482            NA         NA        NA       NA    
## ASV15483            NA         NA        NA       NA    
## ASV2062             NA         NA        NA       NA    
## ASV2132      4.399e+17  6.526e+09  67396431   <2e-16 ***
## ASV2413             NA         NA        NA       NA    
## ASV2490             NA         NA        NA       NA    
## ASV2594      4.337e+14  3.793e+08   1143536   <2e-16 ***
## ASV2822             NA         NA        NA       NA    
## ASV2863             NA         NA        NA       NA    
## ASV2910             NA         NA        NA       NA    
## ASV2980      7.972e+17  1.282e+10  62199372   <2e-16 ***
## ASV3307             NA         NA        NA       NA    
## ASV3474      5.509e+25  3.715e+18  14829838   <2e-16 ***
## ASV3502      3.731e+16  6.477e+08  57610407   <2e-16 ***
## ASV4236             NA         NA        NA       NA    
## ASV4842             NA         NA        NA       NA    
## ASV4894             NA         NA        NA       NA    
## ASV5290             NA         NA        NA       NA    
## ASV5501     -6.408e+16  2.030e+09 -31561118   <2e-16 ***
## ASV5795             NA         NA        NA       NA    
## ASV5987             NA         NA        NA       NA    
## ASV6267             NA         NA        NA       NA    
## ASV6862             NA         NA        NA       NA    
## ASV7145             NA         NA        NA       NA    
## ASV7673             NA         NA        NA       NA    
## ASV7789             NA         NA        NA       NA    
## ASV7809             NA         NA        NA       NA    
## ASV8002             NA         NA        NA       NA    
## ASV8205             NA         NA        NA       NA    
## ASV9155             NA         NA        NA       NA    
## ASV9221     -4.422e+16  2.062e+09 -21450288   <2e-16 ***
## ASV9311             NA         NA        NA       NA    
## ASV9557             NA         NA        NA       NA    
## ASV9936             NA         NA        NA       NA    
## ASV1445     -5.879e+16  1.853e+09 -31719605   <2e-16 ***
## ASV4232             NA         NA        NA       NA    
## ASV6479             NA         NA        NA       NA    
## ASV0142      1.171e+18  7.597e+10  15416523   <2e-16 ***
## ASV0378     -1.798e+17  3.179e+09 -56558628   <2e-16 ***
## ASV1122      1.142e+18  1.348e+10  84701298   <2e-16 ***
## ASV0123     -6.152e+17  3.339e+10 -18424047   <2e-16 ***
## ASV2064     -6.218e+16  1.981e+09 -31388944   <2e-16 ***
## ASV4459     -1.190e+17  1.638e+09 -72644566   <2e-16 ***
## ASV0448     -1.637e+16  2.242e+08 -72998113   <2e-16 ***
## ASV0397     -9.218e+16  1.841e+09 -50077201   <2e-16 ***
## ASV0485     -9.927e+16  1.661e+09 -59770485   <2e-16 ***
## ASV1566             NA         NA        NA       NA    
## ASV1365      1.641e+17  4.070e+09  40312359   <2e-16 ***
## ASV1065             NA         NA        NA       NA    
## ASV0722     -6.746e+16  1.952e+09 -34555746   <2e-16 ***
## ASV12660            NA         NA        NA       NA    
## ASV0223     -6.922e+16  1.846e+09 -37489978   <2e-16 ***
## ASV0229     -5.924e+16  2.029e+09 -29189953   <2e-16 ***
## ASV0877     -5.465e+16  1.986e+09 -27517061   <2e-16 ***
## ASV0983     -7.937e+16  1.838e+09 -43184389   <2e-16 ***
## ASV0626             NA         NA        NA       NA    
## ASV4146     -6.832e+17  2.641e+10 -25872713   <2e-16 ***
## ASV4175     -5.768e+16  2.039e+09 -28294358   <2e-16 ***
## ASV2082     -7.444e+16  1.919e+09 -38799312   <2e-16 ***
## ASV2272     -1.178e+17  1.622e+09 -72663987   <2e-16 ***
## ASV2245     -4.873e+15  3.110e+09  -1566877   <2e-16 ***
## ASV0590             NA         NA        NA       NA    
## ASV0217     -5.831e+16  1.980e+09 -29444555   <2e-16 ***
## ASV0416     -6.619e+16  2.113e+09 -31330716   <2e-16 ***
## ASV1056      2.280e+17  1.630e+10  13986988   <2e-16 ***
## ASV7777             NA         NA        NA       NA    
## ASV0455     -7.155e+16  1.959e+09 -36529190   <2e-16 ***
## ASV0604             NA         NA        NA       NA    
## ASV6100             NA         NA        NA       NA    
## ASV11359            NA         NA        NA       NA    
## ASV6604     -3.107e+15  4.398e+07 -70641463   <2e-16 ***
## ASV5004             NA         NA        NA       NA    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance:  385.39  on 277  degrees of freedom
## Residual deviance: 5911.16  on 198  degrees of freedom
## AIC: 6071.2
## 
## Number of Fisher Scoring iterations: 23

  • For these data, it is not possible to get a decent logistic regression model even when reducing the ASV columns to the minimum from PCA analysis.

  • The goal was to try and estimate or explain which ASVs might present the most impact for Clade C, but thes data from the t–SNE plot above and subsequent logistic modeling attempts do not produce a good model.

  • Please see the RandomForest.Rmd file for non-linear modeling.

Lasso as ASV Selection

1000

LASSO does two things

Shrinks that parameter estimates by penalizing larger slopes -> variance reduction

De-selects variables by setting the slopes to 0 -> dimension reduction.

head(lr_clr_df_1000)
## # A tibble: 6 × 1,002
##   sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##   <chr>      <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
## 1 SKAU-R2-23     1    0      0       0       0      0        0       0    
## 2 SWAJ-R4-3      0    0      0       0       0      0        0       0    
## 3 SYAN-R3-19     1    0      0       0       0      0        0       0    
## 4 PMAQ-R2-19     0    0      0       0       0      0        0       0    
## 5 SDOG-R3-6      0    0      0       0       0      0        0       0    
## 6 PDOG-R2-22     0    1.38   0.913   0.423   0.557  0.0171  -0.340  -0.185
## # ℹ 993 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …

model matrix code here

library(glmnet)


# Create a formula for model.matrix
formula <- as.formula(paste("Clade ~ .", sep = "", collapse = ""), env = environment(lr_clr_df_1000))

# Create the design matrix
x_matrix <- model.matrix(formula, data = lr_clr_df_1000[,-1])

# Convert the response variable to a numerical vector
y_vector <- as.numeric(lr_clr_df_1000$Clade) - 1  # glmnet expects 0/1 coding for binary response

# Fit the LASSO model
lasso_model <- glmnet(x_matrix, 
                      y_vector, 
                      alpha = 1, 
                      family = "binomial")
lasso_model
## 
## Call:  glmnet(x = x_matrix, y = y_vector, family = "binomial", alpha = 1) 
## 
##      Df  %Dev   Lambda
## 1     0  0.00 0.166200
## 2     1  0.71 0.158700
## 3     1  1.35 0.151400
## 4     1  1.95 0.144600
## 5     1  2.49 0.138000
## 6     1  2.98 0.131700
## 7     1  3.44 0.125700
## 8     1  3.85 0.120000
## 9     1  4.24 0.114600
## 10    1  4.59 0.109400
## 11    1  4.91 0.104400
## 12    2  5.27 0.099640
## 13    2  5.82 0.095110
## 14    3  6.61 0.090790
## 15    3  7.36 0.086660
## 16    4  8.06 0.082720
## 17    8  8.89 0.078960
## 18    8  9.75 0.075370
## 19   10 10.64 0.071950
## 20   12 11.70 0.068680
## 21   12 12.77 0.065560
## 22   17 13.88 0.062580
## 23   18 15.07 0.059730
## 24   21 16.46 0.057020
## 25   22 17.84 0.054420
## 26   24 19.17 0.051950
## 27   29 20.45 0.049590
## 28   32 21.78 0.047340
## 29   39 23.18 0.045180
## 30   41 24.59 0.043130
## 31   43 26.01 0.041170
## 32   46 27.47 0.039300
## 33   47 28.85 0.037510
## 34   54 30.33 0.035810
## 35   61 31.92 0.034180
## 36   66 33.54 0.032630
## 37   71 35.11 0.031140
## 38   74 36.63 0.029730
## 39   79 38.16 0.028380
## 40   84 39.70 0.027090
## 41   86 41.27 0.025860
## 42   88 42.79 0.024680
## 43   90 44.24 0.023560
## 44   94 45.67 0.022490
## 45   99 47.05 0.021470
## 46  104 48.40 0.020490
## 47  105 49.74 0.019560
## 48  108 51.04 0.018670
## 49  110 52.29 0.017820
## 50  110 53.47 0.017010
## 51  110 54.60 0.016240
## 52  110 55.69 0.015500
## 53  111 56.72 0.014800
## 54  115 57.74 0.014120
## 55  116 58.72 0.013480
## 56  120 59.67 0.012870
## 57  126 60.60 0.012280
## 58  129 61.50 0.011730
## 59  132 62.36 0.011190
## 60  133 63.19 0.010680
## 61  135 63.97 0.010200
## 62  138 64.73 0.009735
## 63  140 65.46 0.009292
## 64  140 66.15 0.008870
## 65  141 66.81 0.008467
## 66  143 67.44 0.008082
## 67  144 68.05 0.007715
## 68  145 68.63 0.007364
## 69  145 69.19 0.007029
## 70  146 69.72 0.006710
## 71  146 70.23 0.006405
## 72  146 70.71 0.006114
## 73  146 71.17 0.005836
## 74  147 71.61 0.005571
## 75  148 72.02 0.005317
## 76  151 72.42 0.005076
## 77  152 72.80 0.004845
## 78  153 73.17 0.004625
## 79  153 73.51 0.004415
## 80  153 73.84 0.004214
## 81  154 74.15 0.004022
## 82  156 74.45 0.003840
## 83  158 74.73 0.003665
## 84  155 75.00 0.003498
## 85  159 75.26 0.003339
## 86  159 75.50 0.003188
## 87  158 75.74 0.003043
## 88  159 75.96 0.002904
## 89  161 76.17 0.002772
## 90  161 76.38 0.002646
## 91  161 76.57 0.002526
## 92  160 76.76 0.002411
## 93  162 76.93 0.002302
## 94  164 77.09 0.002197
## 95  164 77.25 0.002097
## 96  165 77.41 0.002002
## 97  166 77.55 0.001911
## 98  166 77.69 0.001824
## 99  165 77.82 0.001741
## 100 165 77.95 0.001662
plot(lasso_model, 
     #xlim = c(-0.05, 1)
     )

coef(lasso_model) %>%  # automatically shows 'best' model
  as.matrix() %>% 
  as.data.frame() %>% 
  map(., ~sum(.))
## $s0
## [1] -1.249001e-16
## 
## $s1
## [1] -0.002414881
## 
## $s2
## [1] -0.004742424
## 
## $s3
## [1] -0.007004617
## 
## $s4
## [1] -0.009218581
## 
## $s5
## [1] -0.0113975
## 
## $s6
## [1] -0.0135514
## 
## $s7
## [1] -0.01568771
## 
## $s8
## [1] -0.01781178
## 
## $s9
## [1] -0.01992728
## 
## $s10
## [1] -0.02203651
## 
## $s11
## [1] -0.01244844
## 
## $s12
## [1] 0.037415
## 
## $s13
## [1] 0.07156713
## 
## $s14
## [1] 0.1040534
## 
## $s15
## [1] 0.1329573
## 
## $s16
## [1] 0.2211014
## 
## $s17
## [1] 0.3046685
## 
## $s18
## [1] 0.3740331
## 
## $s19
## [1] 0.449088
## 
## $s20
## [1] 0.5561125
## 
## $s21
## [1] 0.6754546
## 
## $s22
## [1] 0.7664791
## 
## $s23
## [1] 0.7999271
## 
## $s24
## [1] 0.8711823
## 
## $s25
## [1] 0.9874024
## 
## $s26
## [1] 1.109779
## 
## $s27
## [1] 1.226772
## 
## $s28
## [1] 1.3407
## 
## $s29
## [1] 1.317427
## 
## $s30
## [1] 1.148318
## 
## $s31
## [1] 0.9734758
## 
## $s32
## [1] 0.8194264
## 
## $s33
## [1] 0.5963799
## 
## $s34
## [1] 0.3754424
## 
## $s35
## [1] 0.240862
## 
## $s36
## [1] 0.04773582
## 
## $s37
## [1] -0.1725132
## 
## $s38
## [1] -0.3524502
## 
## $s39
## [1] -0.3572257
## 
## $s40
## [1] -0.3719962
## 
## $s41
## [1] -0.4352548
## 
## $s42
## [1] -0.505704
## 
## $s43
## [1] -0.4593212
## 
## $s44
## [1] -0.4263548
## 
## $s45
## [1] -0.4381915
## 
## $s46
## [1] -0.3700628
## 
## $s47
## [1] -0.2126951
## 
## $s48
## [1] -0.0258423
## 
## $s49
## [1] 0.2296777
## 
## $s50
## [1] 0.5173435
## 
## $s51
## [1] 0.826272
## 
## $s52
## [1] 1.169374
## 
## $s53
## [1] 1.578991
## 
## $s54
## [1] 2.049807
## 
## $s55
## [1] 2.523395
## 
## $s56
## [1] 2.987275
## 
## $s57
## [1] 3.402189
## 
## $s58
## [1] 3.795294
## 
## $s59
## [1] 4.122695
## 
## $s60
## [1] 4.436829
## 
## $s61
## [1] 4.793565
## 
## $s62
## [1] 5.200073
## 
## $s63
## [1] 5.623306
## 
## $s64
## [1] 6.057024
## 
## $s65
## [1] 6.451251
## 
## $s66
## [1] 6.843054
## 
## $s67
## [1] 7.294161
## 
## $s68
## [1] 7.832526
## 
## $s69
## [1] 8.367623
## 
## $s70
## [1] 8.893104
## 
## $s71
## [1] 9.387626
## 
## $s72
## [1] 9.876485
## 
## $s73
## [1] 10.36333
## 
## $s74
## [1] 10.84015
## 
## $s75
## [1] 11.30615
## 
## $s76
## [1] 11.75926
## 
## $s77
## [1] 12.29216
## 
## $s78
## [1] 12.7804
## 
## $s79
## [1] 13.22561
## 
## $s80
## [1] 13.65274
## 
## $s81
## [1] 14.12316
## 
## $s82
## [1] 14.62443
## 
## $s83
## [1] 15.13286
## 
## $s84
## [1] 15.6606
## 
## $s85
## [1] 16.1868
## 
## $s86
## [1] 16.72929
## 
## $s87
## [1] 17.3059
## 
## $s88
## [1] 17.9132
## 
## $s89
## [1] 18.54142
## 
## $s90
## [1] 19.18249
## 
## $s91
## [1] 19.81172
## 
## $s92
## [1] 20.40679
## 
## $s93
## [1] 21.01095
## 
## $s94
## [1] 21.6278
## 
## $s95
## [1] 22.23679
## 
## $s96
## [1] 22.84197
## 
## $s97
## [1] 23.45788
## 
## $s98
## [1] 24.06137
## 
## $s99
## [1] 24.653
  • There are many ASVs that have been ‘deselected’ with a dot ..
  • ASV0013 has coefficients
set.seed(123)
lasso_cv <- cv.glmnet(x_matrix, y_vector)
lasso_cv
## 
## Call:  cv.glmnet(x = x_matrix, y = y_vector) 
## 
## Measure: Mean-Squared Error 
## 
##      Lambda Index Measure       SE Nonzero
## min 0.05442    25  0.2257 0.006400      23
## 1se 0.08272    16  0.2311 0.005703       4
plot(lasso_cv)

  • There is a difference of 23 variables vs 4 variables for the models with the minimum lambda vs. the lambda within 1 standard deviation.

  • Default ‘best’ is the lambda within 1 standard deviation of the min lambda.

  • lambda.1se is the default for the coefficients

coef(lasso_cv) %>% 
  as.matrix() %>% 
  as.data.frame() %>% 
  filter(s1 != 0)
##                         s1
## X.Intercept. -4.483266e-01
## ASV0675       4.165648e-02
## ASV0013      -5.246164e-02
## ASV0016      -4.934969e-05
## ASV0010      -7.932463e-03
  • lambda.min results
coef(lasso_cv, s = "lambda.min") %>% 
  as.matrix() %>% 
  as.data.frame() %>% 
  filter(s1 != 0)
##                         s1
## X.Intercept. -4.129516e-01
## ASV1294       1.439031e-02
## ASV2062       4.633545e-03
## ASV1065       3.326552e-03
## ASV1611      -2.558838e-02
## ASV0718       1.844609e-03
## ASV0675       1.003053e-01
## ASV0013      -6.092567e-02
## ASV0016      -1.151795e-02
## ASV0446       9.896810e-03
## ASV0011      -5.951567e-03
## ASV2440       1.624629e-05
## ASV0607       2.755077e-02
## ASV0025      -4.214372e-03
## ASV1262       3.222484e-02
## ASV1136       6.612639e-03
## ASV0164      -6.778447e-03
## ASV0701      -2.259780e-02
## ASV1030       1.428175e-01
## ASV0010      -1.926751e-02
## ASV0096       8.280803e-03
## ASV0128      -5.837785e-02
## ASV1434      -1.252748e-02
## ASV1233      -1.613851e-02

Lasso

500

# the below was previously subset
# the data transformation was completed on the raw counts after the subset
# to preserve the relativeness of the 500
# is, did not subset after clr because the clr transformation is working off of the relative raw counts.
dim(lr_clr_df_500)
## [1] 278 502
head(lr_clr_df_500)
## # A tibble: 6 × 502
##   sample_id  Clade ASV1236 ASV0421 ASV0691 ASV0899 ASV1004 ASV1041 ASV1058
##   <chr>      <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>
## 1 SKAU-R2-23     1    0      0       0       0      0        0       0    
## 2 SWAJ-R4-3      0    0      0       0       0      0        0       0    
## 3 SYAN-R3-19     1    0      0       0       0      0        0       0    
## 4 PMAQ-R2-19     0    0      0       0       0      0        0       0    
## 5 SDOG-R3-6      0    0      0       0       0      0        0       0    
## 6 PDOG-R2-22     0    1.38   0.912   0.421   0.556  0.0158  -0.341  -0.187
## # ℹ 493 more variables: ASV12542 <dbl>, ASV1294 <dbl>, ASV13113 <dbl>,
## #   ASV1318 <dbl>, ASV2269 <dbl>, ASV2542 <dbl>, ASV2660 <dbl>, ASV2737 <dbl>,
## #   ASV2840 <dbl>, ASV3053 <dbl>, ASV3077 <dbl>, ASV3134 <dbl>, ASV3140 <dbl>,
## #   ASV3579 <dbl>, ASV6119 <dbl>, ASV7557 <dbl>, ASV8422 <dbl>, ASV1086 <dbl>,
## #   ASV1310 <dbl>, ASV15750 <dbl>, ASV16905 <dbl>, ASV2033 <dbl>,
## #   ASV2089 <dbl>, ASV2127 <dbl>, ASV2725 <dbl>, ASV2804 <dbl>, ASV3075 <dbl>,
## #   ASV3327 <dbl>, ASV3342 <dbl>, ASV3532 <dbl>, ASV3600 <dbl>, …
# Create a formula for model.matrix
formula_500 <- as.formula(paste("Clade ~ .", sep = "", collapse = ""), env = environment(lr_clr_df_500))

# Create the design matrix
x_matrix_500 <- model.matrix(formula, data = lr_clr_df_500[,-1])

# Convert the response variable to a numerical vector
y_vector_500 <- as.numeric(lr_clr_df_500$Clade) - 1  # glmnet expects 0/1 coding for binary response

# Fit the LASSO model
lasso_model_500 <- glmnet(x_matrix_500, # use the reduced 500 ASV df
                      y_vector_500, # reduced y vector of 0-1 response
                      alpha = 1, 
                      family = "binomial")


#lasso_model_500
plot(lasso_model_500, 
     xlim = c(-0.05, 100), 
     ylim = c(-0.5, 0.5)
     )

coef(lasso_model_500) %>%  # automatically shows 'best' model
  as.matrix() %>% 
  as.data.frame() 
##                           s0          s1          s2          s3          s4
## X.Intercept.   -1.249001e-16  0.01506422  0.02945136  0.04319825  0.05633870
## X.Intercept..1  0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1236         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0421         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0691         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0899         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1004         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1041         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1058         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV12542        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1294         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV13113        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1318         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2269         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2542         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2660         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2737         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2840         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3053         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3077         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3134         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3140         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3579         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6119         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV7557         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV8422         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1086         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1310         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV15750        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV16905        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2033         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2089         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2127         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2725         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2804         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3075         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3327         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3342         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3532         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3600         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4013         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4136         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4195         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4407         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4717         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6794         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV8324         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV8981         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV9859         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0936         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV12683        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1293         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV13055        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV17063        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
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## ASV0958         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0216         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0446         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0367         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0200         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0334         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1311         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0458         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1371         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0418         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0004         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1943         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1495         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0901         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0628         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0400         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0116         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0788         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0117         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3137         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0001         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1651         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1692         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0660         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0508         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1660         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0233         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1343         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0209         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0193         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0357         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0198         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0007         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1772         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0009         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0006         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0011         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0015         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0017         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0235         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0382         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2357         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0567         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0165         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0005         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0384         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0002         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3017         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0091         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0186         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0370         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0018         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1377         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0019         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0023         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2194         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1155         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0510         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2371         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0024         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2452         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2332         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2591         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0521         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV5542         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0336         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV10102        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV16823        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3104         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0781         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV10899        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV11222        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV11327        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV12458        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1636         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1890         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2898         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV8328         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0709         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0856         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0909         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0937         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV11390        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV11966        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV12990        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV14797        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV14904        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV15304        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV16696        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1690         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2029         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2834         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4003         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4064         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4294         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4609         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6283         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6491         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV7453         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV7959         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV8219         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV8547         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV9319         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV9382         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV11516        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV14377        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1867         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1895         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3168         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4449         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6596         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV7492         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV9854         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6296         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4201         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0552         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3671         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3529         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1060         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0239         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV5711         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4152         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1461         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2877         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0012         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV9823         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0008         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV7832         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1915         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0055         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0032         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2977         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0466         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3866         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0040         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0496         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0052         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3828         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1930         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2126         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0793         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0299         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0208         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0511         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1123         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0099         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0752         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0883         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0683         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4117         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2172         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0330         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0728         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0499         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0120         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1446         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV17171        0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0533         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2495         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV5582         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1488         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0682         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0068         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1987         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0035         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV7192         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0873         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV4749         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2174         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1476         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0740         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV0170         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV2466         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1709         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV6170         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV3673         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
## ASV1745         0.000000e+00  0.00000000  0.00000000  0.00000000  0.00000000
##                         s5          s6          s7         s8         s9
## X.Intercept.    0.06890385  0.08092249  0.09242136  0.1034253  0.1139576
## X.Intercept..1  0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1236         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0421         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0691         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0899         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1004         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1041         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1058         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV12542        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1294         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV13113        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1318         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2269         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2542         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2660         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2737         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2840         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3053         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3077         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3134         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3140         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3579         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6119         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV7557         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV8422         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1086         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1310         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV15750        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV16905        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2033         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2089         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2127         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2725         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2804         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3075         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3327         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3342         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3532         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3600         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4013         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4136         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4195         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4407         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4717         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6794         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV8324         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV8981         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV9859         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0936         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV12683        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1293         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV13055        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV17063        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2228         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2769         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2803         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2896         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3062         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3107         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3265         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3666         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4497         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6914         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0576         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0673         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0772         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0862         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0898         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0910         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0964         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV10059        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV10263        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1088         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1101         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1183         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV11956        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV12774        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1321         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV13793        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV14482        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV15483        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2062         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2132         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2413         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2490         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2594         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2822         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2863         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2910         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2980         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3307         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3474         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3502         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4236         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4842         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4894         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV5290         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV5501         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV5795         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV5987         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6267         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
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## ASV0937         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV11390        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV11966        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV12990        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV14797        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV14904        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV15304        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV16696        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1690         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2029         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2834         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4003         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4064         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4294         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4609         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6283         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6491         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV7453         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV7959         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV8219         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV8547         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV9319         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV9382         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV11516        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV14377        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1867         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1895         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3168         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4449         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6596         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV7492         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV9854         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6296         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4201         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0552         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3671         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3529         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1060         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0239         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV5711         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4152         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1461         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2877         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0012         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV9823         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0008         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV7832         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1915         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0055         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0032         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2977         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0466         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3866         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0040         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0496         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0052         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3828         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1930         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2126         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0793         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0299         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0208         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0511         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1123         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0099         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0752         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0883         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0683         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4117         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2172         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0330         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0728         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0499         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0120         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1446         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV17171        0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0533         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2495         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV5582         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1488         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0682         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0068         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1987         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0035         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV7192         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0873         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV4749         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2174         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1476         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0740         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV0170         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV2466         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1709         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV6170         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV3673         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
## ASV1745         0.00000000  0.00000000  0.00000000  0.0000000  0.0000000
##                       s10         s11        s12        s13          s14
## X.Intercept.    0.1240400  0.13530932  0.1480868  0.1603792  0.172723956
## X.Intercept..1  0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1236         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0421         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0691         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0899         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1004         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1041         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1058         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV12542        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1294         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV13113        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1318         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2269         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2542         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2660         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2737         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2840         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3053         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3077         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3134         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3140         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3579         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6119         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7557         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV8422         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1086         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1310         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV15750        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV16905        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2033         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2089         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2127         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2725         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2804         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3075         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3327         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3342         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3532         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3600         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4013         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4136         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4195         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4407         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4717         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6794         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV8324         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV8981         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9859         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0936         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV12683        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1293         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV13055        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV17063        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2228         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2769         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2803         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2896         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3062         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3107         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3265         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3666         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4497         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6914         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0576         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0673         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0772         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0862         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0898         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0910         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0964         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV10059        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV10263        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1088         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1101         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1183         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV11956        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV12774        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1321         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV13793        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV14482        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV15483        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2062         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2132         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2413         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2490         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2594         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2822         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2863         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2910         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2980         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3307         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3474         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3502         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4236         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4842         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4894         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV5290         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV5501         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV5795         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV5987         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6267         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6862         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7145         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7673         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7789         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7809         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV8002         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV8205         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9155         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9221         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9311         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9557         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9936         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1445         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4232         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6479         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0142         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0378         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1122         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0123         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2064         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4459         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0448         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0397         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0485         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1566         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1365         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1065         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0722         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV12660        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0223         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0229         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0877         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0983         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0626         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4146         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4175         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2082         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2272         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2245         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0590         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0217         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0416         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1056         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7777         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0455         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0604         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6100         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV11359        0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6604         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV5004         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1483         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV9773         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4059         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1193         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4610         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0742         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1502         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0195         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1213         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1648         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6984         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0396         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4297         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2622         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3512         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2411         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2291         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0807         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1292         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1035         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0070         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0255         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0057         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0077         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0625         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2464         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1315         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2673         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2161         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0337         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7680         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0611         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3118         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1284         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0889         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4649         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1108         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0738         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0473         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0598         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0429         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1549         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1203         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4532         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0274         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0412         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0104         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV3883         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0801         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0227         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0833         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0766         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0290         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0033         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
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## ASV0068         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1987         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0035         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV7192         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0873         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV4749         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2174         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1476         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0740         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV0170         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV2466         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1709         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV6170         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV3673         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
## ASV1745         0.0000000  0.00000000  0.0000000  0.0000000  0.000000000
##                         s15           s16          s17          s18         s19
## X.Intercept.    0.184651261  0.1967100170  0.220650899  0.243775015  0.27031896
## X.Intercept..1  0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV1236         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV0421         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV0691         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV0899         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV1004         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV1041         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV1058         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV12542        0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV1294         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV13113        0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV1318         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV2269         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV2542         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV2660         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
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## ASV3077         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV3134         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV3140         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV3579         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
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## ASV8981         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV9859         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV0936         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
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## ASV1293         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV13055        0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
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## ASV2228         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV2769         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
## ASV2803         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
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## ASV3666         0.000000000  0.0000000000  0.000000000  0.000000000  0.00000000
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##                         s20          s21         s22         s23          s24
## X.Intercept.    0.298413803  0.329242078  0.35878807  0.38659008  0.412300437
## X.Intercept..1  0.000000000  0.000000000  0.00000000  0.00000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.00000000  0.00000000  0.000000000
## ASV0421         0.000000000  0.000000000  0.00000000  0.00000000  0.000000000
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## ASV0024        -0.003665183 -0.012384350 -0.02151070 -0.02992034 -0.037657042
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##                         s25           s26          s27          s28
## X.Intercept.    0.434883989  0.4533302369  0.472261413  0.490822949
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## ASV0009         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0006         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0011        -0.061229166 -0.0661065406 -0.070557348 -0.074986478
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## ASV0017         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV0024        -0.041652845 -0.0435601142 -0.043865340 -0.043701371
## ASV2452         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV2834         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV4003         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV11516        0.000000000  0.0000000000  0.000000000  0.000000000
## ASV14377        0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV1895         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV4449         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV6296         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV4201         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0552         0.000000000  0.0014040429  0.003606653  0.004936062
## ASV3671         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV3529         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1060         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0239         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV5711         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV4152         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1461         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV0012         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV9823         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV0040         0.003427031  0.0076116909  0.011430463  0.015772600
## ASV0496         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV0499         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0120         0.000000000 -0.0006893704 -0.015893095 -0.030419783
## ASV1446         0.000000000  0.0000000000  0.000000000  0.000000000
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##                         s29           s30          s31           s32
## X.Intercept.    0.507544001  5.237845e-01  0.544661853  0.5762801743
## X.Intercept..1  0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1236         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0421         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV0899         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1004         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV12542        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1294         0.086312196  9.624176e-02  0.106603437  0.1207828134
## ASV13113        0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV3134         0.084035959  1.061834e-01  0.126664129  0.1438537245
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## ASV0909         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0937         0.000000000 -1.550618e-02 -0.052073093 -0.0841688869
## ASV11390        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV11966        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV12990        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV14797        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV14904        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV15304        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV16696        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1690         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2029         0.197675946  2.250022e-01  0.247477017  0.2715782066
## ASV2834         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4003         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4064         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4294         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4609         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV6283         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV6491         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV7453         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV7959         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV8219         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV8547         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV9319         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV9382         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV11516        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV14377        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1867         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1895         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3168         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4449         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV6596         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV7492         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV9854         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV6296         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4201         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0552         0.005047506  4.169590e-03  0.000000000  0.0000000000
## ASV3671         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3529         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1060         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0239         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV5711         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4152         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1461         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2877         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0012         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV9823         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0008         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV7832         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1915         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0055         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0032         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2977         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0466         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3866         0.000000000  0.000000e+00  0.010651918  0.0376733957
## ASV0040         0.015936005  1.414672e-02  0.007406650  0.0003662758
## ASV0496         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0052         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3828         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1930         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2126         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0793         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0299         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0208         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0511         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1123         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0099         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0752         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0883         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0683         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4117         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2172         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0330        -0.008718284 -1.759967e-02 -0.024459366 -0.0309334177
## ASV0728         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0499         0.000000000  0.000000e+00  0.002330100  0.0150153096
## ASV0120        -0.042586007 -5.353732e-02 -0.065145026 -0.0756460286
## ASV1446         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV17171        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0533         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2495         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV5582         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1488         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0682         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0068         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1987         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0035         0.000000000  0.000000e+00 -0.003352862 -0.0196765204
## ASV7192         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0873         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4749         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2174         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1476         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0740         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0170         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2466         0.000000000  0.000000e+00  0.000000000 -0.0126252331
## ASV1709         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV6170         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3673         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1745         0.000000000  0.000000e+00  0.000000000  0.0000000000
##                         s33          s34          s35          s36          s37
## X.Intercept.    0.606540150  0.637894504  0.669546192  0.698879556  0.727238098
## X.Intercept..1  0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0421         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0691         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0899         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1004         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1041         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1058         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12542        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1294         0.134307293  0.146072425  0.162983575  0.181305706  0.199529055
## ASV13113        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1318         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2269         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2542         0.000000000  0.000000000  0.000000000  0.000000000  0.020034542
## ASV2660         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2737         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2840         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3053         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3077         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3134         0.159616295  0.175486611  0.193675564  0.212497339  0.230333264
## ASV3140         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3579         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6119         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7557         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8422         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1086         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1310         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2804         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3075         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3327         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3342         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV6794         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8324         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8981         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9859         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0936         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12683        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1293         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV13055        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV17063        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2803         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2896         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0910         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0964         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV10059        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV15483        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2594         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV7673         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7789         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7809         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8002         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8205         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0123         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0937        -0.114589501 -0.143894258 -0.171081917 -0.198769838 -0.226712742
## ASV11390        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV11966        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12990        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV14797        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV14904        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV15304        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV16696        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1690         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2029         0.299685996  0.329576922  0.357326657  0.371818587  0.378559258
## ASV2834         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4003         0.058468411  0.153127341  0.250907604  0.344746570  0.425847817
## ASV4064         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4294         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4609         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6283         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6491         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7453         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7959         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8219         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8547         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9319         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9382         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV11516        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV14377        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1867         0.000000000  0.000000000  0.000000000  0.000000000  0.026001998
## ASV1895         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3168         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4449         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6596         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7492         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9854         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6296         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4201         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0552         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3671         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3529         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1060         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0239         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5711         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4152         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1461         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2877         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0012         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9823         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0008         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7832         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1915         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0055         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0032         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2977         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0466         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3866         0.061850353  0.086440789  0.112537759  0.137734610  0.161116407
## ASV0040         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0496         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0052         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3828         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1930         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2126         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0793         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0299         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0208         0.000000000  0.002144947  0.009733266  0.017003731  0.024357744
## ASV0511         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1123         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0099         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0752         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0883         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0683         0.000000000  0.000000000  0.000000000  0.000000000  0.004966851
## ASV4117         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2172         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0330        -0.037142487 -0.044359722 -0.051435236 -0.058883613 -0.065771346
## ASV0728         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0499         0.026594451  0.037968692  0.048029881  0.054530440  0.059781566
## ASV0120        -0.084553358 -0.093054207 -0.098574162 -0.102002489 -0.104797916
## ASV1446         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV17171        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0533         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2495         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5582         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1488         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0682         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0068         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1987         0.000000000  0.000000000  0.000000000 -0.007573206 -0.036320961
## ASV0035        -0.034948445 -0.050225329 -0.065074585 -0.079690342 -0.094661066
## ASV7192         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0873         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4749         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2174         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1476         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0740         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0170         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2466        -0.027525210 -0.042231559 -0.055368194 -0.069362751 -0.086055877
## ASV1709         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6170         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3673         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1745         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
##                         s38          s39          s40          s41          s42
## X.Intercept.    0.753765681  0.782497676  0.809612771  0.836577414  0.865546822
## X.Intercept..1  0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0421         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0691         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0899         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1004         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1041         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1058         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12542        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1294         0.221054615  0.238995563  0.259498281  0.276276024  0.291672976
## ASV13113        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1318         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2269         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2542         0.040647832  0.062028219  0.082910139  0.103578948  0.124147155
## ASV2660         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2737         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2840         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3053         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3077         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3134         0.247487673  0.265456370  0.282711835  0.298821285  0.315043694
## ASV3140         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3579         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6119         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7557         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8422         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1086         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1310         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV15750        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV16905        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2033         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2089         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2127         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2725         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2804         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3075         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3327         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3342         0.000000000  0.002370946  0.006028509  0.000000000  0.000000000
## ASV3532         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3600         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4013         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4136         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4195         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4407         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4717         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6794         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8324         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8981         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9859         0.000000000  0.000000000  0.000000000  0.000000000  0.008307286
## ASV0936         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12683        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1293         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV13055        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV17063        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2228         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2769         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2803         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2896         0.000000000  0.000000000  0.000000000  0.000000000  0.009414291
## ASV3062         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3107         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3265         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3666         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0576         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0862         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0898         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0910         0.000000000  0.000000000  0.000000000  0.012918371  0.028420663
## ASV0964         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV10059        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV10263        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1088         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1101         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1183         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV11956        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12774        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1321         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV15483        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2062         0.293017895  0.292349468  0.293765581  0.295821776  0.299600264
## ASV2132         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2413         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2490         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2594         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2822         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2863         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2910         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV3307         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3474         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3502         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4236         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV4894         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5290         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5501         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5795         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5987         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV6862         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7145         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7673         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7789         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7809         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8002         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV8205         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9155         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9221         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9311         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV9936         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV6479         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0142         0.000000000 -0.014351011 -0.025348421 -0.033883162 -0.038044104
## ASV0378         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1122         0.193107662  0.250906714  0.310497135  0.369143939  0.426947080
## ASV0123         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2064         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0485         0.050774169  0.029234262  0.008088860  0.000000000  0.000000000
## ASV1566         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1365         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1065         0.119354390  0.131722389  0.145952839  0.157649964  0.167583224
## ASV0722         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0590         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0217         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0416         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0455         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV11359        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0035        -0.108120598 -0.120725380 -0.131193971 -0.140474911 -0.150414630
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## ASV1709         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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##                         s43           s44          s45          s46
## X.Intercept.    0.892897541  0.9166003148  0.941046632  0.969204117
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## ASV1236         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV0012         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV9823         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0008         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV7832         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1915         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0055         0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV2977         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0466         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV3866         0.268609538  0.2774371741  0.285409711  0.294315051
## ASV0040         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0496         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0052         0.004182992  0.0120791305  0.018773741  0.024696328
## ASV3828         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1930         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV2126         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0793         0.105853186  0.1402463358  0.172873778  0.208140916
## ASV0299         0.000000000  0.0000000000  0.000000000 -0.001722997
## ASV0208         0.080152715  0.0942742096  0.109713423  0.127003297
## ASV0511         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1123         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0099         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0752         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0883         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0683         0.121882209  0.1352842050  0.145220079  0.145217821
## ASV4117         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV2172         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0330        -0.109778052 -0.1150083312 -0.120782416 -0.126233932
## ASV0728         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0499         0.073215757  0.0741156527  0.073891386  0.073168722
## ASV0120        -0.108686739 -0.1023249883 -0.095676768 -0.090735398
## ASV1446         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV17171        0.000000000  0.0000000000  0.000000000  0.000000000
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## ASV5582         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1488         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0682         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0068         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1987        -0.191569818 -0.2114733664 -0.226996023 -0.241603328
## ASV0035        -0.162537737 -0.1783489919 -0.193426483 -0.208630369
## ASV7192         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0873         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV4749         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV2174         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1476         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV0740        -0.122878836 -0.1404854843 -0.156088970 -0.171034005
## ASV0170         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV2466        -0.152764601 -0.1660806812 -0.179125050 -0.190925603
## ASV1709         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV6170         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV3673         0.000000000  0.0000000000  0.000000000  0.000000000
## ASV1745         0.000000000  0.0000000000  0.000000000  0.000000000
##                         s47          s48          s49          s50          s51
## X.Intercept.    0.996804941  1.023861100  1.053869354  1.087079736  1.119924171
## X.Intercept..1  0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0421         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0691         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0899         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1004         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1041         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1058         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12542        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1294         0.266114063  0.250365154  0.246396853  0.252798056  0.264451025
## ASV13113        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1318         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2269         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2542         0.186419043  0.198065290  0.209361254  0.219310576  0.231431066
## ASV2660         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2737         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2840         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3053         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3077         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3134         0.405420716  0.422545089  0.440138424  0.459268498  0.478713279
## ASV3140         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3579         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV3075         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3327         0.111328931  0.136021198  0.155218361  0.168278897  0.176869027
## ASV3342         0.074891029  0.087328957  0.095814643  0.105582777  0.116462819
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## ASV6794         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV8981         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9859         0.199764975  0.234031883  0.267328529  0.298759272  0.327187421
## ASV0936         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12683        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV13055        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV17063        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2769         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2803         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2896         0.146063155  0.172024054  0.198727020  0.221364107  0.244701570
## ASV3062         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0898         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0910         0.110638997  0.128324318  0.142280657  0.152907449  0.159003426
## ASV0964         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV1088         0.184965036  0.220406481  0.254304815  0.285716177  0.315770969
## ASV1101         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2062         0.340837716  0.352758291  0.361107978  0.365891051  0.373687239
## ASV2132         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV5987         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0142        -0.019165340 -0.010792181 -0.001864891  0.000000000  0.000000000
## ASV0378         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1122         0.725747570  0.781020038  0.829068109  0.870193125  0.897371491
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## ASV3529         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1060         0.088707242  0.100867750  0.112889057  0.126031640  0.138480562
## ASV0239         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV5711         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4152        -0.076428140 -0.110752106 -0.154341853 -0.192716847 -0.226875888
## ASV1461         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2877         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0012         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9823         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0008         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV7832         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1915         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0055         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0032         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2977         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0466         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3866         0.299507827  0.306017690  0.314851664  0.324621950  0.338050825
## ASV0040         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0496         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0052         0.028625409  0.030845302  0.034968463  0.042689387  0.051114862
## ASV3828         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2126         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0793         0.250762625  0.293759213  0.335710833  0.371587851  0.409092825
## ASV0299        -0.013791315 -0.026003807 -0.038004136 -0.047802365 -0.059198848
## ASV0208         0.146203251  0.167200087  0.187139226  0.207554530  0.224951426
## ASV0511         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0683         0.138604439  0.133145563  0.131172726  0.134435492  0.140821427
## ASV4117         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2172         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0330        -0.129872512 -0.133543024 -0.136762342 -0.138480068 -0.138669137
## ASV0728         0.000000000  0.000000000  0.015357012  0.025253558  0.025697124
## ASV0499         0.073041658  0.072173594  0.073154073  0.075808081  0.076942456
## ASV0120        -0.088827264 -0.087234314 -0.086837701 -0.087084682 -0.084382807
## ASV1446         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV17171        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV5582         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0068         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1987        -0.258527302 -0.277161937 -0.296350350 -0.316307742 -0.334239674
## ASV0035        -0.224646428 -0.240668598 -0.256406791 -0.269382457 -0.283859299
## ASV7192         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0873         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV4749        -0.006191304 -0.034085996 -0.059841393 -0.080651179 -0.105672187
## ASV2174         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1476         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0740        -0.184042357 -0.199794217 -0.224334537 -0.253241537 -0.283765244
## ASV0170         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2466        -0.202777794 -0.214059231 -0.224877350 -0.233677288 -0.242324581
## ASV1709         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6170         0.000000000  0.000000000  0.000000000 -0.003466721 -0.008613556
## ASV3673         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1745         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
##                         s52          s53          s54          s55          s56
## X.Intercept.    1.153115273  1.183257595  1.211207733  1.237152095  1.261507101
## X.Intercept..1  0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0421         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0691         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV0899         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1004         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1041         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1058         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12542        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1294         0.274650128  0.288476320  0.292656317  0.297463657  0.304051345
## ASV13113        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1318         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2269         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2542         0.247187000  0.263022899  0.281172539  0.294904163  0.307476273
## ASV2660         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2840         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3053         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3077         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3134         0.497722610  0.519785044  0.545391935  0.573123847  0.600341175
## ASV3140         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3579         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV3075         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3327         0.175992480  0.177305279  0.174583608  0.170425534  0.171697213
## ASV3342         0.125492685  0.141925261  0.172819113  0.203635996  0.231669083
## ASV3532         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV6794         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV8981         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV9859         0.353904556  0.380366909  0.406353895  0.432267573  0.457264146
## ASV0936         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV12683        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1293         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV13055        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV17063        0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV2803         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2896         0.266950003  0.290645486  0.317564989  0.349432534  0.381301356
## ASV3062         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0910         0.161311054  0.166622855  0.173887326  0.183713058  0.194653938
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## ASV1088         0.343753226  0.375706467  0.404015862  0.431816845  0.459647104
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## ASV2062         0.384080104  0.391543892  0.404727118  0.416535899  0.427287823
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## ASV6862         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV4232         0.035998311  0.045065951  0.052820448  0.061126883  0.069992588
## ASV6479         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV1122         0.922139989  0.951176712  0.978986710  1.014609266  1.051700567
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## ASV0590        -0.096306821 -0.140468608 -0.186078822 -0.211855224 -0.234033465
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## ASV0239         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV4152        -0.258531328 -0.291289701 -0.305913968 -0.325323477 -0.347438931
## ASV1461         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0466         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV3866         0.352533125  0.365434736  0.376641676  0.387349496  0.397721248
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## ASV0052         0.058992048  0.065189122  0.071292666  0.077677574  0.083795343
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## ASV0299        -0.072003284 -0.084465306 -0.098529385 -0.111759486 -0.124596138
## ASV0208         0.240575613  0.254576374  0.262961020  0.271953571  0.281748383
## ASV0511         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV0728         0.024431626  0.021938053  0.025366516  0.032970968  0.039585650
## ASV0499         0.077938322  0.079618190  0.082123709  0.084138311  0.085506813
## ASV0120        -0.081587588 -0.077773380 -0.071573720 -0.063719987 -0.055660957
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## ASV0035        -0.299361414 -0.314253151 -0.329405342 -0.342725102 -0.354973510
## ASV7192         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV4749        -0.133369105 -0.159331681 -0.183832794 -0.204309200 -0.224187578
## ASV2174         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV1476         0.000000000 -0.002837698 -0.029246056 -0.058030421 -0.085789806
## ASV0740        -0.317626111 -0.356114660 -0.394677045 -0.436446819 -0.480803194
## ASV0170         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV2466        -0.251018132 -0.257284910 -0.261339650 -0.266960724 -0.273541383
## ASV1709         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
## ASV6170        -0.009851866 -0.013817602 -0.029953284 -0.051171235 -0.065750222
## ASV3673         0.000000000  0.000000000  0.000000000  0.000000000  0.000000000
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##                         s57           s58           s59           s60
## X.Intercept.    1.282517968  1.3006788916  1.3144738088  1.3272088167
## X.Intercept..1  0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1236         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0421         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0691         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0899         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1004         0.000000000  0.0000000000  0.0000000000  0.0000000000
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## ASV1294         0.307686790  0.3014783589  0.2809495101  0.2480687904
## ASV13113        0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1318         0.000000000  0.0000000000  0.0000000000  0.0000000000
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## ASV2977         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0466         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV3866         0.391638064  0.3750037172  0.3658505588  0.3561134573
## ASV0040         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0496         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0052         0.089361640  0.0969752544  0.1054198490  0.1130383214
## ASV3828         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1930         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV2126         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0793         0.650415370  0.6845314439  0.7252780461  0.7707705382
## ASV0299        -0.136459338 -0.1472592224 -0.1596143344 -0.1725341897
## ASV0208         0.291015328  0.3009092408  0.3116813356  0.3279056784
## ASV0511         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1123         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0099         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0752         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0883         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0683         0.208101742  0.2167321078  0.2223972947  0.2201391742
## ASV4117         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV2172         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0330        -0.148424488 -0.1534019330 -0.1563170373 -0.1576294216
## ASV0728         0.042400393  0.0438370577  0.0349216594  0.0169853700
## ASV0499         0.085934783  0.0855366175  0.0857543868  0.0849676225
## ASV0120        -0.037327376 -0.0167330163 -0.0014705616  0.0000000000
## ASV1446         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV17171        0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0533         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV2495         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV5582         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1488         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0682         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0068         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1987        -0.393401506 -0.3974796763 -0.4071295578 -0.4125220287
## ASV0035        -0.365030452 -0.3720776838 -0.3803573825 -0.3874652404
## ASV7192         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV0873         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV4749        -0.245661703 -0.2592083099 -0.2609928130 -0.2625912748
## ASV2174         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1476        -0.109179776 -0.1294635666 -0.1512771463 -0.1795869501
## ASV0740        -0.504499644 -0.5129161006 -0.5220973264 -0.5227259323
## ASV0170         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV2466        -0.279334867 -0.2833118471 -0.2778986452 -0.2721149510
## ASV1709         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV6170        -0.079558532 -0.0817896538 -0.0916055949 -0.1220036609
## ASV3673         0.000000000  0.0000000000  0.0000000000  0.0000000000
## ASV1745         0.000000000  0.0000000000  0.0000000000  0.0000000000
##                          s61           s62          s63           s64
## X.Intercept.    1.338025e+00  1.3504697124  1.362399560  1.3757712883
## X.Intercept..1  0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1236         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0421         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0691         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0899         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1004         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1041         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1058         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV12542        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1294         2.119192e-01  0.1830052476  0.153212373  0.1356019769
## ASV13113        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1318         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2269         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2542         3.487718e-01  0.3589068138  0.367220370  0.3801352467
## ASV2660         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2737         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2840         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3053         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3077         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3134         7.224876e-01  0.7470487637  0.772456454  0.7963429592
## ASV3140         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3579         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6119         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV7557         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV8422         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1086         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1310         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV15750        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV16905        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2033         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2089         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2127         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2725         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2804         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3075         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3327         1.193144e-01  0.0843515991  0.040683904  0.0008196455
## ASV3342         5.070131e-01  0.5501536615  0.598823714  0.6359248576
## ASV3532         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3600         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4013         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4136         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4195         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4407         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4717         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6794         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV8324         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV8981         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV9859         5.711461e-01  0.5948824565  0.618126007  0.6410634425
## ASV0936         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV12683        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1293         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV13055        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV17063        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2228         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2769         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2803         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2896         5.666137e-01  0.6070083997  0.650719462  0.6939732663
## ASV3062         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3107         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3265         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3666         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4497         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6914         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0576         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0673         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0772         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0862         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0898         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0910         3.324053e-01  0.3583448404  0.386554947  0.4126953075
## ASV0964         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV10059        0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## ASV1088         6.458759e-01  0.6605652015  0.668707907  0.6782572980
## ASV1101         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1183         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV11956        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV12774        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1321         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV13793        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV14482        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV15483        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2062         4.601443e-01  0.4660197159  0.472586267  0.4780045052
## ASV2132         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2413         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2490         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2594         0.000000e+00  0.0000000000  0.000000000  0.0014370706
## ASV2822         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2863         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2910         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2980         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3307         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3474         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3502         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4236         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4842         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4894         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV5290         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV5501         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV5795         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV5987         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6267         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6862         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV7145         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV7673         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV7789         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV7809         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV8002         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV8205         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV9155         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV9221         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV9311         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV9557         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV9936         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1445         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4232         1.634355e-01  0.1760999872  0.187359932  0.1944260684
## ASV6479         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0142         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0378         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1122         1.278025e+00  1.3027122143  1.327583796  1.3524887652
## ASV0123         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2064         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4459         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0448         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0397         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0485         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1566         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1365         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1065         1.215079e-01  0.1004068349  0.077380461  0.0528923808
## ASV0722         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV12660        0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0223         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0229         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0877         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0983         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0626         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4146         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4175         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2082         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2272         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2245         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0590        -2.188785e-01 -0.2221615407 -0.225838391 -0.2375043169
## ASV0217         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0416         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1056         1.177695e-01  0.1239483480  0.130778554  0.1389697185
## ASV7777        -1.141846e+00 -1.2199660107 -1.296615952 -1.3665503038
## ASV0455         0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## ASV6100        -2.312951e-01 -0.2589804537 -0.287029373 -0.3144105023
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## ASV9773        -2.212661e-01 -0.2241055060 -0.226833616 -0.2277701374
## ASV4059         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1193         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4610         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0742         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1502         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0195         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1213         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1648         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6984        -7.059837e-02 -0.0905102313 -0.109575599 -0.1292137138
## ASV0396         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV4297         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2622         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV3512         9.568484e-02  0.1236586071  0.152660126  0.1847285691
## ASV2411         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2291         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0807         2.352594e-02  0.0245783074  0.024459326  0.0236948470
## ASV1292         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV1035         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0070         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0255        -3.456122e-02 -0.0487165995 -0.062985487 -0.0784674366
## ASV0057         0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## ASV1315         5.795811e-01  0.5922899010  0.602602331  0.6167048356
## ASV2673         2.796098e-01  0.2759756503  0.273536748  0.2746867449
## ASV2161         0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## ASV0738         5.313898e-01  0.5607658658  0.588455803  0.6154242689
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## ASV0227        -1.040728e-01 -0.1201017471 -0.133907564 -0.1470980862
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## ASV1139         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0766         0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## ASV1987        -4.191226e-01 -0.4255111210 -0.430672108 -0.4311218030
## ASV0035        -3.955553e-01 -0.4033189343 -0.409825342 -0.4160688110
## ASV7192         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV0873         0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## ASV1476        -2.090303e-01 -0.2387325721 -0.269658456 -0.2990271127
## ASV0740        -5.211613e-01 -0.5258417212 -0.530695100 -0.5483468850
## ASV0170         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV2466        -2.653616e-01 -0.2595286243 -0.253038960 -0.2440760648
## ASV1709         0.000000e+00  0.0000000000  0.000000000  0.0000000000
## ASV6170        -1.581042e-01 -0.1849262612 -0.209414375 -0.2417897802
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## ASV1745         0.000000e+00  0.0000000000  0.000000000  0.0000000000
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## X.Intercept.    1.384830352  1.390138166  1.3979673068  1.408066419
## X.Intercept..1  0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.0000000000  0.000000000
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## ASV1294         0.122460394  0.104663255  0.0871521426  0.078047164
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## ASV0446         0.301954184  0.315921622  0.3303135353  0.343334182
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##                          s69          s70           s71          s72
## X.Intercept.    1.4170091385  1.427759759  1.4363684922  1.432921050
## X.Intercept..1  0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV0417         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV0648         0.0000000000  0.000000000  0.0000000000  0.000000000
## ASV0407        -0.0751769508 -0.084029247 -0.0925361240 -0.101189538
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## ASV0958         0.5761898381  0.593218857  0.6096996145  0.626434954
## ASV0216        -0.4976018344 -0.521079915 -0.5425001422 -0.561805748
## ASV0446         0.3562668175  0.369504768  0.3815842662  0.397870535
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## ASV0788         1.2906489132  1.322780912  1.3452694471  1.355766866
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## ASV0005         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV0023         0.0000000000  0.000000000  0.0000000000  0.000000000
## ASV2194         0.1281684299  0.128928638  0.1310583083  0.134412970
## ASV1155         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV0024        -0.1060297542 -0.106696980 -0.1045837829 -0.099612332
## ASV2452         0.0000000000  0.000000000  0.0000000000  0.000000000
## ASV2332         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV0521         0.0869571617  0.086285462  0.0817262570  0.075223452
## ASV5542         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV10899        1.4545146197  1.493053205  1.5281906635  1.561363677
## ASV11222        0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV4003         2.4666865481  2.554966691  2.6480453558  2.737267513
## ASV4064         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV1895         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV4449         5.1999098699  5.372957725  5.5035413662  5.615062560
## ASV6596         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV1060         0.3522557883  0.365538435  0.3794661464  0.396727286
## ASV0239         0.0000000000  0.000000000  0.0000000000  0.000000000
## ASV5711         0.0000000000  0.000000000  0.0000000000  0.000000000
## ASV4152        -0.2100485202 -0.211486695 -0.2140548431 -0.196491888
## ASV1461         0.0000000000  0.000000000  0.0000000000  0.000000000
## ASV2877         0.0000000000  0.000000000  0.0000000000  0.000000000
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## ASV0035        -0.4530067432 -0.461906024 -0.4703748186 -0.478101895
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## ASV0740        -0.7012686318 -0.751248190 -0.8037113643 -0.868669989
## ASV0170        -0.0362716574 -0.042902618 -0.0514574308 -0.063652032
## ASV2466        -0.1825675863 -0.169579515 -0.1533890179 -0.133509183
## ASV1709         0.0000000000  0.000000000  0.0516426297  0.136814455
## ASV6170        -0.4080083590 -0.434428640 -0.4571718855 -0.478929456
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##                          s73           s74          s75          s76
## X.Intercept.    1.4327063120  1.4324987977  1.430626955  1.433043597
## X.Intercept..1  0.0000000000  0.0000000000  0.000000000  0.000000000
## ASV1236         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV2452         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV10899        1.5843335980  1.6107421124  1.641561382  1.656210367
## ASV11222        0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV1895         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV4449         5.7252415142  5.8363779408  5.947833480  6.065416924
## ASV6596         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV1060         0.4131651444  0.4307227475  0.449976426  0.467309338
## ASV0239         0.0000000000  0.0000000000  0.000000000  0.000000000
## ASV5711         0.0000000000  0.0000000000  0.000000000  0.000000000
## ASV4152        -0.1787413334 -0.1574274531 -0.134248171 -0.133678528
## ASV1461         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV9823         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV7832         0.0000000000  0.0000000000  0.000000000  0.000000000
## ASV1915         0.0000000000  0.0000000000  0.000000000  0.000000000
## ASV0055        -0.0001088495 -0.0009982151 -0.003482617 -0.006002766
## ASV0032         0.2286776828  0.2456267962  0.263212261  0.279287988
## ASV2977         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV0299        -0.2168598356 -0.2119038463 -0.206242678 -0.204572633
## ASV0208         0.5916202936  0.6192455856  0.648464451  0.677096835
## ASV0511         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV0728         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV1987        -0.4081917003 -0.4063334479 -0.399855175 -0.402671742
## ASV0035        -0.4853039700 -0.4929125324 -0.500966924 -0.510469954
## ASV7192         0.0000000000  0.0000000000  0.000000000  0.000000000
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## ASV4749        -0.0777463128 -0.0822717026 -0.084630408 -0.098274108
## ASV2174         0.0000000000  0.0000000000  0.000000000  0.000000000
## ASV1476        -0.5077002688 -0.5383847254 -0.569232253 -0.591386511
## ASV0740        -0.9442488336 -1.0179550237 -1.085408256 -1.134297901
## ASV0170        -0.0755105394 -0.0876860802 -0.100939066 -0.111480467
## ASV2466        -0.1162098005 -0.0967942044 -0.070749941 -0.026500112
## ASV1709         0.2102510281  0.2882825422  0.371744575  0.433339378
## ASV6170        -0.4992613307 -0.5165162119 -0.529125910 -0.532076310
## ASV3673         0.0000000000  0.0000000000  0.000000000  0.000000000
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##                         s77           s78          s79           s80
## X.Intercept.    1.432631870  1.434948e+00  1.437660702  1.4439990298
## X.Intercept..1  0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1236         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0421         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV1041         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV1294         0.010878140  2.160898e-02  0.015961566  0.0173774967
## ASV13113        0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV2542         0.744867415  7.621366e-01  0.770339706  0.7815527979
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## ASV3134         1.137052337  1.172286e+00  1.197076008  1.2196779975
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## ASV11222        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV11327        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV12458        0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1636         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1890         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2898         1.195415557  1.208275e+00  1.241036691  1.2650851364
## ASV8328         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0709         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV0552         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3671         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3529         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1060         0.482525937  4.972985e-01  0.508365147  0.5174324218
## ASV0239         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV5711         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4152        -0.148335546 -1.627849e-01 -0.198287245 -0.2168781054
## ASV1461         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2877         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0012         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV9823         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0008         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV7832         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1915         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0055        -0.004737477  0.000000e+00  0.000000000  0.0000000000
## ASV0032         0.294601532  3.079581e-01  0.319674051  0.3343755365
## ASV2977         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0466         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV3866         0.328194368  3.209584e-01  0.311584137  0.3094211224
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## ASV0052         0.279620144  2.948013e-01  0.319748745  0.3400075936
## ASV3828        -0.415296159 -4.486393e-01 -0.484230296 -0.5147744963
## ASV1930         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2126         0.008515691  2.273307e-02  0.040885003  0.0621167021
## ASV0793         1.521846739  1.581650e+00  1.651455272  1.7204508535
## ASV0299        -0.202742787 -2.019922e-01 -0.199936563 -0.1955216274
## ASV0208         0.721168486  7.592831e-01  0.806437377  0.8532443116
## ASV0511         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV0883         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0683         0.236094031  2.464181e-01  0.219679434  0.2078555870
## ASV4117         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV2172         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0330        -0.258810518 -2.673970e-01 -0.278928216 -0.2884334986
## ASV0728         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0499         0.032062977  3.032408e-02  0.026604541  0.0240025694
## ASV0120         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV1488         0.000000000  0.000000e+00  0.000000000  0.0000000000
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## ASV0068        -0.034190331 -5.149192e-02 -0.084757061 -0.1106998907
## ASV1987        -0.413371248 -4.280500e-01 -0.448031109 -0.4701262337
## ASV0035        -0.516027228 -5.212693e-01 -0.525896453 -0.5324119313
## ASV7192         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV0873         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV4749        -0.107545169 -1.199304e-01 -0.125221137 -0.1327770063
## ASV2174         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1476        -0.601816480 -6.118288e-01 -0.616235157 -0.6279938728
## ASV0740        -1.132407028 -1.150309e+00 -1.135499756 -1.1481437868
## ASV0170        -0.119159516 -1.265850e-01 -0.131338229 -0.1363573733
## ASV2466         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1709         0.501348223  5.474577e-01  0.605751210  0.6658867372
## ASV6170        -0.531010155 -5.353489e-01 -0.530348876 -0.5261786666
## ASV3673         0.000000000  0.000000e+00  0.000000000  0.0000000000
## ASV1745         0.000000000  0.000000e+00  0.000000000  0.0000000000
##                         s81          s82           s83          s84
## X.Intercept.    1.452943914  1.463192570  1.4746848612  1.485336452
## X.Intercept..1  0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1236         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0421         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0691         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0899         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1004         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1041         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1058         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV12542        0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1294         0.016962512  0.026142891  0.0488520360  0.076415908
## ASV13113        0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1318         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV2269         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV2542         0.793758843  0.806637946  0.8166667729  0.820983376
## ASV2660         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV2737         0.000000000  0.000000000  0.0000000000  0.000000000
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## ASV3134         1.241686274  1.267594883  1.2992745302  1.336714408
## ASV3140         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV3579         0.304199099  0.330679958  0.3597207141  0.387589130
## ASV6119         0.000000000  0.000000000  0.0000000000  0.000000000
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## ASV0910         0.873056980  0.870705584  0.8637510607  0.851748422
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## ASV5711         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV4152        -0.222175874 -0.222131333 -0.2186276528 -0.207935637
## ASV1461         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV2877         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0012         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV9823         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0008         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV7832         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1915         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0055         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0032         0.350048401  0.364477019  0.3770129960  0.387083422
## ASV2977         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0466         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV3866         0.311726518  0.319472639  0.3318059119  0.342478454
## ASV0040         0.008286268  0.016331196  0.0212667035  0.022140182
## ASV0496         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0052         0.363032818  0.386190467  0.4076458541  0.423122918
## ASV3828        -0.546498918 -0.576602277 -0.6053062574 -0.638567032
## ASV1930         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV2126         0.083207564  0.100790706  0.1117678046  0.113609149
## ASV0793         1.793216147  1.865487316  1.9346961883  2.010004190
## ASV0299        -0.189539517 -0.184014844 -0.1808082045 -0.180519814
## ASV0208         0.899293391  0.943372277  0.9828388828  1.020317411
## ASV0511         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1123         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0099         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0752        -0.070393470 -0.088869357 -0.1076392191 -0.128227455
## ASV0883         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0683         0.207642588  0.205585732  0.2002016823  0.189230074
## ASV4117         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV2172         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0330        -0.296576421 -0.304219167 -0.3115759062 -0.319848153
## ASV0728         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0499         0.021417937  0.018318996  0.0147826867  0.009066998
## ASV0120         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1446         0.000000000  0.000000000  0.0000000000  0.000000000
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## ASV0533         0.000000000  0.000000000  0.0000000000  0.000000000
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## ASV1488         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0682         0.000000000 -0.003668900 -0.0119331827 -0.022089183
## ASV0068        -0.141052259 -0.171117319 -0.1961845702 -0.216993223
## ASV1987        -0.497802672 -0.524243941 -0.5528518076 -0.585352924
## ASV0035        -0.539925629 -0.548301626 -0.5571541239 -0.565282405
## ASV7192         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV0873         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV4749        -0.141923965 -0.155838130 -0.1679092725 -0.185932731
## ASV2174         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1476        -0.635685620 -0.648499449 -0.6657990622 -0.686067584
## ASV0740        -1.169116964 -1.203607658 -1.2390210426 -1.272989024
## ASV0170        -0.140389546 -0.144697638 -0.1503858694 -0.156877691
## ASV2466         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1709         0.718610635  0.775118989  0.8281641946  0.873226217
## ASV6170        -0.513702834 -0.508530511 -0.5135562644 -0.512924726
## ASV3673         0.000000000  0.000000000  0.0000000000  0.000000000
## ASV1745         0.000000000  0.000000000  0.0000000000  0.000000000
##                         s85         s86         s87           s88           s89
## X.Intercept.    1.493014223  1.50443597  1.51790165  1.5330098928  1.5499773534
## X.Intercept..1  0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1236         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV0421         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV0691         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV0899         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1004         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1041         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1058         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV12542        0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1294         0.109232947  0.14181010  0.17552313  0.2121016439  0.2518358368
## ASV13113        0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1318         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV2269         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV2542         0.827012439  0.83465159  0.84327127  0.8507760676  0.8570275553
## ASV2660         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
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## ASV3053         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV3077         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV3134         1.378424420  1.42330893  1.47007022  1.5173274591  1.5666138319
## ASV3140         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV3579         0.408978815  0.43273387  0.45641263  0.4853378190  0.5150043484
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## ASV9859         1.000326322  1.02666211  1.05249383  1.0790384948  1.1058364399
## ASV0936         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
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## ASV17063        0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
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## ASV2769         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV2803         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV2896         1.598959028  1.65767193  1.71533660  1.7747504877  1.8324659296
## ASV3062         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
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## ASV3666         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
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## ASV0877        -0.202706735 -0.23711276 -0.27318815 -0.3140580504 -0.3535692989
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## ASV4749        -0.209966010 -0.23386305 -0.25152074 -0.2701638744 -0.2909221369
## ASV2174         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1476        -0.710747732 -0.73469208 -0.75888771 -0.7821323746 -0.8065887974
## ASV0740        -1.318793640 -1.37055575 -1.41561766 -1.4599630624 -1.5124825890
## ASV0170        -0.162806602 -0.16786546 -0.17192827 -0.1753777676 -0.1774016819
## ASV2466         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
## ASV1709         0.926840221  0.97957528  1.02656066  1.0726171574  1.1181736888
## ASV6170        -0.505626667 -0.49054391 -0.48023352 -0.4671707867 -0.4603343973
## ASV3673         0.000000000  0.00000000  0.00000000  0.0000000000  0.0000000000
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##                         s90          s91          s92          s93
## X.Intercept.    1.566693957  1.585680160  1.606296912  1.628163380
## X.Intercept..1  0.000000000  0.000000000  0.000000000  0.000000000
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## ASV1294         0.292108613  0.334736297  0.379743343  0.426397248
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## ASV0396         0.0000000000  0.00000000
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## ASV3512         0.9299749711  0.94465075
## ASV2411         0.0000000000  0.00000000
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## ASV0255        -0.1074354265 -0.10792051
## ASV0057         0.0000000000  0.00000000
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## ASV0625         0.0000000000  0.00000000
## ASV2464         0.0000000000  0.00000000
## ASV1315         0.9408842465  0.95811918
## ASV2673         0.9374780924  0.96687436
## ASV2161         0.0000000000  0.00000000
## ASV0337        -0.1279756729 -0.13758461
## ASV7680         0.0000000000  0.00000000
## ASV0611         1.5378504982  1.56424554
## ASV3118        -1.4044799264 -1.44726070
## ASV1284         0.0000000000  0.00000000
## ASV0889         0.0000000000  0.00000000
## ASV4649         0.0000000000  0.00000000
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## ASV0738         0.9367124392  0.93744564
## ASV0473         0.0000000000  0.00000000
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## ASV1203         0.0000000000  0.00000000
## ASV4532         0.0000000000  0.00000000
## ASV0274        -0.6253059851 -0.64262348
## ASV0163         0.0000000000  0.00000000
## ASV1298         0.0000000000  0.00000000
## ASV9424        -1.7967545904 -1.81144620
## ASV0412         1.1723164482  1.22068769
## ASV0284         0.0000000000  0.00000000
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## ASV0801         0.0000000000  0.00000000
## ASV1611        -1.2112779267 -1.21603688
## ASV0227        -0.9605672335 -0.98930566
## ASV0833         0.0000000000  0.00000000
## ASV0718         1.1474656652  1.16497767
## ASV1139         0.0000000000  0.00000000
## ASV0766         0.0000000000  0.00000000
## ASV2091         0.0000000000  0.00000000
## ASV1238        -4.5825297688 -4.66213506
## ASV9193        -0.1800392864 -0.17371643
## ASV0290         0.0000000000  0.00000000
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## ASV0185         1.3954786675  1.42479091
## ASV2330         0.0000000000  0.00000000
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## ASV2368        -1.0257895773 -1.03514944
## ASV0122         0.0000000000  0.00000000
## ASV1044         0.0000000000  0.00000000
## ASV0160        -0.1100556895 -0.11502805
## ASV0326        -0.1330517466 -0.13869596
## ASV1388         0.0000000000  0.00000000
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## ASV0390         0.0000000000  0.00000000
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## ASV3348         0.0000000000  0.00000000
## ASV0058         0.0000000000  0.00000000
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## ASV0033         0.0000000000  0.00000000
## ASV4354         0.0000000000  0.00000000
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## ASV0415         0.0000000000  0.00000000
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## ASV0471         0.1470062356  0.15996037
## ASV0451         0.0000000000  0.00000000
## ASV0747         0.0000000000  0.00000000
## ASV1314        -0.9030716215 -0.91436937
## ASV0425         0.0000000000  0.00000000
## ASV0559         0.0000000000  0.00000000
## ASV0148         0.7542315331  0.77194438
## ASV0129         0.9839758346  0.99772309
## ASV1072         0.0000000000  0.00000000
## ASV2390         0.0000000000  0.00000000
## ASV0548         0.2327132069  0.23814828
## ASV0168        -0.0566257593 -0.05916530
## ASV0066         0.2295794240  0.23704562
## ASV0468         0.0000000000  0.00000000
## ASV0172         0.1382853537  0.14245874
## ASV0236         0.0000000000  0.00000000
## ASV0250         0.6612581364  0.67252378
## ASV0338         0.0000000000  0.00000000
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## ASV1022         0.2087839423  0.21527517
## ASV6174         0.0000000000  0.00000000
## ASV0786         0.0000000000  0.00000000
## ASV0053        -1.0714413518 -1.08979937
## ASV0697        -0.3241811536 -0.32873415
## ASV0785         0.0000000000  0.00000000
## ASV1967         0.0000000000  0.00000000
## ASV0385         0.1034550767  0.11298597
## ASV0295         0.3508274507  0.35813282
## ASV0072        -0.1083343694 -0.11443100
## ASV0157         0.5760658968  0.58532291
## ASV0501         0.0000000000  0.00000000
## ASV10729       -1.1399770479 -1.16116963
## ASV1470         0.0000000000  0.00000000
## ASV0050         0.0000000000  0.00000000
## ASV0411        -0.9565126057 -0.97700456
## ASV0549        -0.2009195973 -0.20122133
## ASV0184         0.6068863954  0.62206850
## ASV0705         0.0000000000  0.00000000
## ASV1715         0.2900247882  0.29520789
## ASV0603         0.0000000000  0.00000000
## ASV0826         0.0000000000  0.00000000
## ASV0034        -0.1005394649 -0.10447884
## ASV0838        -0.7313719716 -0.74735072
## ASV0614         0.0000000000  0.00000000
## ASV0014         0.0000000000  0.00000000
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## ASV2085        -2.0895824929 -2.13478188
## ASV0003         0.0000000000  0.00000000
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## ASV0654         0.0000000000  0.00000000
## ASV0151         0.0000000000  0.00000000
## ASV0065        -0.0720802863 -0.07395600
## ASV0527         0.0000000000  0.00000000
## ASV4055        -0.5756296398 -0.58077419
## ASV0166         0.0000000000  0.00000000
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## ASV0322         0.0000000000  0.00000000
## ASV0156        -1.3932039001 -1.43278496
## ASV0648         0.0000000000  0.00000000
## ASV0407        -0.3317062525 -0.34198386
## ASV2030         0.0000000000  0.00000000
## ASV0300         0.0000000000  0.00000000
## ASV1150         0.0000000000  0.00000000
## ASV0958         1.0340409783  1.04665245
## ASV0216        -1.0563903779 -1.07768734
## ASV0446         0.3389846493  0.33856881
## ASV0367        -0.5273011298 -0.54512712
## ASV0200         0.0000000000  0.00000000
## ASV0334         0.0000000000  0.00000000
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## ASV0458         0.0000000000  0.00000000
## ASV1371         0.0000000000  0.00000000
## ASV0418         0.0000000000  0.00000000
## ASV0004         0.0000000000  0.00000000
## ASV1943         0.0000000000  0.00000000
## ASV1495        -0.2913680353 -0.30039945
## ASV0901        -0.8935621612 -0.90280530
## ASV0628        -0.2100807190 -0.21587128
## ASV0400        -0.2319210981 -0.24119241
## ASV0116        -0.1613929645 -0.15838293
## ASV0788         1.9983985879  2.02497272
## ASV0117         0.7145923351  0.73258328
## ASV3137         0.1289446236  0.13627555
## ASV0001         0.0000000000  0.00000000
## ASV1651         0.3177004861  0.32015565
## ASV1692         1.6620354573  1.68684205
## ASV0660         0.0000000000  0.00000000
## ASV0508         0.0000000000  0.00000000
## ASV1660         0.0000000000  0.00000000
## ASV0233         0.0404283407  0.05083227
## ASV1343        -0.8128689175 -0.82666763
## ASV0209         0.0000000000  0.00000000
## ASV0193         0.0000000000  0.00000000
## ASV0357         0.7477247617  0.75723429
## ASV0198         0.0000000000  0.00000000
## ASV0007         0.0000000000  0.00000000
## ASV1772         2.1865134266  2.22442718
## ASV0009         0.0000000000  0.00000000
## ASV0006         0.0000000000  0.00000000
## ASV0011        -0.2686471152 -0.26918191
## ASV0015         0.0000000000  0.00000000
## ASV0017         0.0000000000  0.00000000
## ASV0235        -0.4590125382 -0.47057991
## ASV0382        -0.3608357577 -0.36598877
## ASV2357         0.0000000000  0.00000000
## ASV0567        -0.5791436016 -0.59377548
## ASV0165         0.0456681848  0.04311480
## ASV0005         0.0000000000  0.00000000
## ASV0384         0.1819717844  0.18600489
## ASV0002         0.0000000000  0.00000000
## ASV3017         0.0000000000  0.00000000
## ASV0091        -0.3567478113 -0.36182992
## ASV0186         0.0000000000  0.00000000
## ASV0370         0.0000000000  0.00000000
## ASV0018         0.0000000000  0.00000000
## ASV1377         0.0000000000  0.00000000
## ASV0019         0.1312240102  0.13363890
## ASV0023         0.0000000000  0.00000000
## ASV2194         0.0602399477  0.05620380
## ASV1155         0.0000000000  0.00000000
## ASV0510         0.0000000000  0.00000000
## ASV2371         0.0000000000  0.00000000
## ASV0024         0.0000000000  0.00000000
## ASV2452         0.0000000000  0.00000000
## ASV2332         0.0000000000  0.00000000
## ASV2591         0.0000000000  0.00000000
## ASV0521         0.0931881052  0.09693053
## ASV5542         0.0000000000  0.00000000
## ASV0336         0.0000000000  0.00000000
## ASV10102        0.0000000000  0.00000000
## ASV16823        0.0000000000  0.00000000
## ASV3104         0.0000000000  0.00000000
## ASV0781         0.0000000000  0.00000000
## ASV10899        1.6759263896  1.70083252
## ASV11222        0.0000000000  0.00000000
## ASV11327        0.0000000000  0.00000000
## ASV12458        0.0000000000  0.00000000
## ASV1636         0.0000000000  0.00000000
## ASV1890         0.0000000000  0.00000000
## ASV2898         0.8793471177  0.84370429
## ASV8328         0.0000000000  0.00000000
## ASV0709         0.0000000000  0.00000000
## ASV0856         0.0000000000  0.00000000
## ASV0909         0.0000000000  0.00000000
## ASV0937        -0.5682739804 -0.56589213
## ASV11390        0.0000000000  0.00000000
## ASV11966        0.0000000000  0.00000000
## ASV12990        0.0000000000  0.00000000
## ASV14797        0.0000000000  0.00000000
## ASV14904        0.0000000000  0.00000000
## ASV15304        0.0000000000  0.00000000
## ASV16696        0.0000000000  0.00000000
## ASV1690         0.0000000000  0.00000000
## ASV2029         1.6159941511  1.63329112
## ASV2834         0.0000000000  0.00000000
## ASV4003         4.9229614985  4.99395509
## ASV4064         0.0000000000  0.00000000
## ASV4294         2.6171814010  2.67799552
## ASV4609         0.0000000000  0.00000000
## ASV6283         0.0000000000  0.00000000
## ASV6491         0.0000000000  0.00000000
## ASV7453         0.0000000000  0.00000000
## ASV7959         0.0000000000  0.00000000
## ASV8219         0.0000000000  0.00000000
## ASV8547         0.0000000000  0.00000000
## ASV9319         0.0943513737  0.10580577
## ASV9382         0.0000000000  0.00000000
## ASV11516        0.0000000000  0.00000000
## ASV14377        0.0000000000  0.00000000
## ASV1867         1.3537602777  1.37637654
## ASV1895         0.0000000000  0.00000000
## ASV3168         0.0000000000  0.00000000
## ASV4449         8.2515449534  8.36058919
## ASV6596         0.0000000000  0.00000000
## ASV7492         0.0000000000  0.00000000
## ASV9854         0.0000000000  0.00000000
## ASV6296         0.0000000000  0.00000000
## ASV4201         0.3652085010  0.41827668
## ASV0552         0.0000000000  0.00000000
## ASV3671        -0.0412613002 -0.05265996
## ASV3529         0.0000000000  0.00000000
## ASV1060         0.7265755453  0.73891265
## ASV0239         0.0000000000  0.00000000
## ASV5711         0.0000000000  0.00000000
## ASV4152         0.0000000000  0.00000000
## ASV1461         0.0000000000  0.00000000
## ASV2877         0.0000000000  0.00000000
## ASV0012         0.0000000000  0.00000000
## ASV9823         0.0000000000  0.00000000
## ASV0008         0.0000000000  0.00000000
## ASV7832         0.0000000000  0.00000000
## ASV1915         0.0000000000  0.00000000
## ASV0055         0.0000000000  0.00000000
## ASV0032         0.5355268457  0.54508590
## ASV2977         0.0000000000  0.00000000
## ASV0466         0.0000000000  0.00000000
## ASV3866         0.5122484573  0.52787138
## ASV0040         0.0729700635  0.07382539
## ASV0496         0.0000000000  0.00000000
## ASV0052         0.5678072483  0.57497760
## ASV3828        -0.9903323479 -1.01062084
## ASV1930         0.0000000000  0.00000000
## ASV2126         0.1934805721  0.20181287
## ASV0793         3.1882518356  3.25922233
## ASV0299        -0.2189126828 -0.22253898
## ASV0208         1.5064378696  1.54127682
## ASV0511         0.0000000000  0.00000000
## ASV1123         0.0000000000  0.00000000
## ASV0099         0.0000000000  0.00000000
## ASV0752        -0.2482446514 -0.25569030
## ASV0883         0.0000000000  0.00000000
## ASV0683         0.1366171385  0.14355385
## ASV4117         0.0000000000  0.00000000
## ASV2172         0.0000000000  0.00000000
## ASV0330        -0.4268069701 -0.43536258
## ASV0728         0.0000000000  0.00000000
## ASV0499         0.0000000000  0.00000000
## ASV0120         0.0000000000  0.00000000
## ASV1446         0.0000000000  0.00000000
## ASV17171        0.0000000000  0.00000000
## ASV0533         0.0000000000  0.00000000
## ASV2495         0.0000000000  0.00000000
## ASV5582        -0.0236832864 -0.05854704
## ASV1488         0.0000000000  0.00000000
## ASV0682        -0.1642038029 -0.17424069
## ASV0068        -0.4204653206 -0.43597806
## ASV1987        -0.9233255446 -0.94303346
## ASV0035        -0.7101037236 -0.71929755
## ASV7192         0.0000000000  0.00000000
## ASV0873         0.0000000000  0.00000000
## ASV4749        -0.5404860862 -0.57528956
## ASV2174         0.0000000000  0.00000000
## ASV1476        -1.0858909155 -1.12422320
## ASV0740        -2.1055406086 -2.16321436
## ASV0170        -0.1793283035 -0.18054109
## ASV2466         0.0000000000  0.00000000
## ASV1709         1.5000047713  1.53976515
## ASV6170        -0.4292629868 -0.43418748
## ASV3673         0.0000000000  0.00000000
## ASV1745         0.0000000000  0.00000000
set.seed(123)
lasso_500_cv <- cv.glmnet(x_matrix_500, y_vector_500)

Lasso Model Resuts for 500 ASVs with Cross-Validation

lasso_500_cv
## 
## Call:  cv.glmnet(x = x_matrix_500, y = y_vector_500) 
## 
## Measure: Mean-Squared Error 
## 
##      Lambda Index Measure       SE Nonzero
## min 0.05894    24  0.2251 0.006517      11
## 1se 0.09385    14  0.2307 0.004954       2
coef(lasso_500_cv) %>% # default is lambda.1se
  as.matrix() %>% 
  as.data.frame() %>% 
  filter(s1 != 0)
##                       s1
## X.Intercept. -0.46033867
## ASV0675       0.02485676
## ASV0013      -0.04966277
coef(lasso_500_cv, s = "lambda.min") %>% 
  as.matrix() %>% 
  as.data.frame() %>% 
  filter(s1 != 0)
##                        s1
## X.Intercept. -0.406661226
## ASV1294       0.001186688
## ASV2062       0.031146444
## ASV0485       0.009920936
## ASV1611      -0.016774693
## ASV0675       0.092846237
## ASV0013      -0.066531340
## ASV0016      -0.006562546
## ASV0446       0.019176703
## ASV0011      -0.012004576
## ASV0024      -0.007634862
## ASV2029       0.006947465
  • With lambda.1se, the best model is with 2 ASVs:

ASV0675 and ASV0013

  • With lambda.min, the best model is with 11 ASVs:

ASV1294

ASV2062

ASV0485

ASV1611

ASV0675

ASV0013

ASV0016

ASV0446

ASV0011

plot(lasso_500_cv)